TDMS Study 05019-03 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
CI PIGMENT RED 3
NTP Experiment-Test: 05019-03 Report: PEIRPT05
Study Type: CHRONIC Date: 09/03/94
Route: DOSED FEED Time: 14:37:35
Facility: Southern Research Institute
Chemical CAS #: 2425-85-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05019-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 14:37:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.6% 1.25% 2.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 15 7 8 7
Dead 3 2 3 3
Survivors
Terminal Sacrifice 32 40 39 40
Dead 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (9) (12) (50)
Sarcoma, Metastatic, Uterus 1 (8%)
Intestine Large, Rectum (50) (10) (12) (50)
Polyp Adenomatous 1 (2%)
Intestine Small, Duodenum (50) (10) (11) (49)
Sarcoma, Metastatic, Uterus 1 (9%)
Intestine Small, Jejunum (48) (9) (9) (49)
Sarcoma, Metastatic, Uterus 1 (11%)
Liver (50) (50) (50) (50)
Hepatocellular Adenoma 1 (2%) 9 (18%)
Hepatocellular Adenoma, Multiple 1 (2%)
Mesentery (6) (6) (10) (4)
Adenocarcinoma, Metastatic, Uterus 1 (17%)
Sarcoma, Metastatic, Uterus 1 (10%)
Pancreas (50) (50) (50) (49)
Sarcoma, Metastatic, Uterus 1 (2%)
Pharynx (2) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (50%)
Stomach, Forestomach (50) (9) (12) (50)
Sarcoma, Metastatic, Uterus 1 (8%)
Stomach, Glandular (50) (9) (12) (50)
Sarcoma, Metastatic, Uterus 1 (8%)
Tongue (2)
Squamous Cell Carcinoma 2 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05019-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 14:37:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.6% 1.25% 2.5%
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (12) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (16) (13) (50)
Adenoma 2 (4%) 1 (6%)
Hemangiosarcoma 1 (2%)
Capsule, Sarcoma, Metastatic, Uterus 1 (8%)
Adrenal Gland, Medulla (49) (16) (13) (50)
Pheochromocytoma Malignant 1 (6%)
Pheochromocytoma Complex 1 (2%) 1 (8%)
Pheochromocytoma Benign 4 (8%) 3 (19%) 4 (8%)
Islets, Pancreatic (49) (50) (50) (49)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (50) (22) (20) (50)
Pars Distalis, Adenoma 23 (46%) 13 (59%) 11 (55%) 21 (42%)
Pars Distalis, Adenoma, Multiple 1 (5%)
Pars Distalis, Adenoma, Multiple, Two 2 (4%) 1 (2%)
Pars Distalis, Carcinoma 1 (5%)
Thyroid Gland (50) (12) (13) (50)
C-Cell, Adenoma 6 (12%) 1 (8%) 1 (8%) 6 (12%)
C-Cell, Carcinoma 1 (2%) 2 (17%) 1 (8%)
Follicular Cell, Adenoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (14) (14) (50)
Adenoma 9 (19%) 1 (7%) 1 (2%)
Ovary (50) (14) (14) (50)
Leiomyosarcoma 1 (7%)
Uterus (50) (23) (28) (50)
Adenocarcinoma 1 (2%)
Adenoma 1 (2%)
Fibroma 1 (2%)
Fibrous Histiocytoma 1 (2%)
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (4%) 1 (2%)
Page 3
NTP Experiment-Test: 05019-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 14:37:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.6% 1.25% 2.5%
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Polyp Stromal 9 (18%) 7 (30%) 5 (18%) 9 (18%)
Polyp Stromal, Multiple, Two 1 (2%) 1 (4%) 1 (2%)
Sarcoma 1 (4%)
Sarcoma Stromal 1 (2%) 1 (2%)
Vagina (7) (5) (1)
Sarcoma 1 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10) (12) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (50) (50) (50) (50)
Iliac, Adenocarcinoma, Metastatic, Uterus 1 (2%)
Mesenteric, Sarcoma, Metastatic, Uterus 1 (2%)
Renal, Adenocarcinoma, Metastatic, Uterus 1 (2%)
Lymph Node, Mandibular (50) (50) (50) (49)
Spleen (50) (50) (50) (50)
Sarcoma 1 (2%)
Thymus (49) (11) (12) (50)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50)
Adenocarcinoma 3 (6%) 1 (2%)
Adenocarcinoma, Multiple 1 (2%)
Adenoma 1 (2%)
Fibroadenoma 15 (30%) 13 (26%) 16 (33%) 11 (22%)
Fibroadenoma, Multiple 8 (16%) 3 (6%) 4 (8%) 1 (2%)
Myoepithelioma 1 (2%)
Skin (50) (26) (33) (50)
Keratoacanthoma 2 (4%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (4%) 1 (3%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (4%) 1 (3%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (15) (16) (50)
Vertebra, Coccygeal, Chordoma 1 (7%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05019-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 14:37:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.6% 1.25% 2.5%
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (13) (50)
Astrocytoma Malignant 1 (8%)
Carcinoma, Metastatic, Pituitary Gland 1 (8%)
Ependymoma Malignant 2 (15%)
Glioma Malignant 1 (2%)
Oligodendroglioma Malignant 1 (10%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Adenocarcinoma, Metastatic, Mammary Gland 1 (2%)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Lipoma 1 (2%)
Urinary Bladder (50) (10) (12) (50)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 10 (20%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05019-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 14:37:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.6% 1.25% 2.5%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 35 38 41
Total Primary Neoplasms 109 55 57 79
Total Animals with Benign Neoplasms 44 31 32 38
Total Benign Neoplasms 88 45 42 72
Total Animals with Malignant Neoplasms 17 10 14 7
Total Malignant Neoplasms 21 10 15 7
Total Animals with Metastatic Neoplasms 2 1 2
Total Metastatic Neoplasm 6 1 10
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05019-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 14:37:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.6% 1.25% 2.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 9 9 9
Early Deaths
Moribund 17 7 16 26
Dead 5 4 7 5
Survivors
Terminal Sacrifice 28 40 28 20
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (10) (19) (50)
Polyp Adenomatous 1 (2%)
Intestine Large, Colon (50) (10) (22) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Polyp Adenomatous 1 (5%)
Intestine Small, Duodenum (50) (9) (21) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Intestine Small, Ileum (50) (9) (19) (49)
Intestine Small, Jejunum (50) (10) (20) (49)
Leiomyosarcoma 1 (2%)
Liver (50) (50) (50) (50)
Carcinoma, Multiple, Metastatic, Two, Kidney 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 3 (6%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Mesentery (11) (6) (6) (6)
Carcinoma, Multiple, Metastatic, Greater
Than Five, Kidney 1 (17%)
Fibrosarcoma, Metastatic, Spleen 1 (9%)
Hemangiosarcoma 1 (17%)
Osteosarcoma, Metastatic, Bone 1 (17%)
Oral Mucosa (1)
Gingival, Squamous Cell Carcinoma 1 (100%)
Pancreas (50) (50) (49) (50)
Carcinoma, Multiple, Metastatic, Two, Kidney 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Acinar Cell, Adenoma 1 (2%) 1 (2%)
Salivary Glands (50) (10) (22) (50)
Stomach, Forestomach (50) (10) (22) (49)
Osteosarcoma, Metastatic, Bone 1 (2%)
Squamous Cell Carcinoma 1 (5%)
Page 7
NTP Experiment-Test: 05019-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 14:37:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.6% 1.25% 2.5%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Stomach, Glandular (50) (10) (22) (49)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (11) (27) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (4%)
Carcinoma, Metastatic, Kidney 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50) (50)
Adrenal Gland, Cortex (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Capsule, Carcinoma, Multiple, Metastatic,
Two, Kidney 1 (2%)
Capsule, Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Gland, Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 6 (12%) 7 (14%) 9 (18%) 3 (6%)
Pheochromocytoma Malignant, Multiple 1 (2%) 1 (2%)
Pheochromocytoma Benign 16 (32%) 11 (22%) 20 (40%) 22 (44%)
Pheochromocytoma Benign, Multiple 6 (12%) 18 (36%) 15 (30%) 12 (24%)
Islets, Pancreatic (50) (50) (49) (50)
Adenoma 5 (10%) 2 (4%)
Adenoma, Multiple 1 (2%)
Pituitary Gland (50) (16) (25) (50)
Pars Distalis, Adenoma 17 (34%) 9 (56%) 8 (32%) 12 (24%)
Pars Distalis, Carcinoma 1 (6%)
Pars Distalis, Carcinoma, Metastatic,
Zymbal's Gland 1 (4%)
Pars Intermedia, Carcinoma, Metastatic,
Zymbal's Gland 1 (4%)
Pars Nervosa, Carcinoma, Metastatic,
Zymbal's Gland 1 (4%)
Thyroid Gland (50) (11) (23) (50)
C-Cell, Adenoma 4 (8%) 4 (8%)
C-Cell, Carcinoma 2 (4%) 1 (9%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Adenoma, Cystic 1 (2%)
Follicular Cell, Adenoma, Cystic, Papillary 1 (4%)
Follicular Cell, Carcinoma 1 (2%) 1 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05019-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 14:37:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.6% 1.25% 2.5%
CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (10) (23) (50)
Preputial Gland (49) (13) (25) (50)
Adenoma 6 (12%) 1 (4%) 1 (2%)
Carcinoma 1 (2%)
Prostate (50) (10) (22) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Seminal Vesicle (50) (11) (22) (50)
Carcinoma, Metastatic, Kidney 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Testes (50) (49) (48) (50)
Interstitial Cell, Adenoma 6 (12%) 12 (24%) 6 (13%) 12 (24%)
Interstitial Cell, Adenoma, Multiple 41 (82%) 35 (71%) 39 (81%) 37 (74%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10) (22) (49)
Lymph Node (50) (50) (50) (50)
Axillary, Basosquamous Tumor Malignant,
Metastatic, Skin 1 (2%)
Axillary, Osteosarcoma, Metastatic, Bone 1 (2%)
Mediastinal, Basosquamous Tumor Malignant,
Metastatic, Skin 1 (2%)
Mediastinal, Carcinoma, Multiple, Metastatic,
Two, Kidney 1 (2%)
Pancreatic, Squamous Cell Carcinoma,
Metastatic, Stomach 1 (2%)
Lymph Node, Mandibular (48) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Spleen (50) (50) (50) (49)
Carcinoma, Multiple, Metastatic, Two, Kidney 1 (2%)
Fibrosarcoma 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%) 2 (4%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Thymus (44) (10) (19) (49)
Epithelial Cell, Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05019-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 14:37:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.6% 1.25% 2.5%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (13) (24) (48)
Adenocarcinoma 1 (2%)
Fibroadenoma 2 (4%) 1 (4%) 2 (4%)
Fibroadenoma, Multiple 1 (2%)
Skin (50) (31) (47) (50)
Basal Cell Adenoma 1 (2%) 2 (6%) 1 (2%)
Basosquamous Tumor Malignant 1 (2%)
Carcinoma 1 (2%)
Keratoacanthoma 2 (4%) 2 (4%) 2 (4%)
Squamous Cell Papilloma 4 (13%) 2 (4%) 6 (12%)
Trichoepithelioma 1 (2%) 1 (3%)
Subcutaneous Tissue, Fibroma 4 (8%) 2 (4%) 4 (8%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 2 (6%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Osteosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (10) (22) (50)
Osteosarcoma 1 (5%) 1 (2%)
Skeletal Muscle (1) (1)
Diaphragm, Osteosarcoma, Metastatic, Bone 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (11) (22) (50)
Astrocytoma Malignant 1 (2%) 1 (5%)
Carcinoma, Multiple, Metastatic, Greater
Than Five, Zymbal's Gland 1 (5%)
Carcinoma, Metastatic, Pituitary Gland 1 (9%)
Glioma Malignant 1 (5%)
Meningioma Malignant 1 (9%)
Spinal Cord (1)
Chordoma 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Basosquamous Tumor Malignant, Multiple,
Page 10
NTP Experiment-Test: 05019-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 14:37:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.6% 1.25% 2.5%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Metastatic, Greater Than Five, Skin 1 (2%)
Carcinoma, Multiple, Metastatic, Greater
Than Five, Kidney 1 (2%)
Carcinoma, Multiple, Metastatic, Greater
Than Five, Zymbal's Gland 1 (2%) 1 (2%)
Chordoma, Metastatic 1 (2%)
Osteosarcoma, Multiple, Metastatic, Greater
Than Five, Bone 1 (2%)
Pheochromocytoma Malignant, Multiple,
Metastatic, Greater Than Five, Adrenal
Gland 1 (2%)
Schwannoma Malignant, Multiple, Metastatic,
Three, Ear 1 (2%)
Nose (50) (10) (22) (50)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (2)
Schwannoma Benign 2 (100%)
Schwannoma Malignant 1 (50%)
Zymbal's Gland (2) (3)
Carcinoma 2 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (49)
Carcinoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Renal Tubule, Oncocytoma Benign 1 (2%)
Transitional Epithelium, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 22 (44%) 6 (12%) 2 (4%) 1 (2%)
Mesothelioma Malignant 3 (6%) 1 (2%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05019-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 3 Date: 09/03/94
Route: DOSED FEED Time: 14:37:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.6% 1.25% 2.5%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 50 50
Total Primary Neoplasms 164 122 135 141
Total Animals with Benign Neoplasms 49 50 50 49
Total Benign Neoplasms 117 98 108 123
Total Animals with Malignant Neoplasms 32 22 22 16
Total Malignant Neoplasms 47 24 27 18
Total Animals with Metastatic Neoplasms 1 3 5 3
Total Metastatic Neoplasm 1 3 14 21
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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