TDMS Study 05019-03 Pathology Tables
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
Facility: Southern Research Institute
Chemical CAS #: 2425-85-6
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 2| 2| 5| 8| 2| 2| 2| 8| 1| 2| 2| 2| 8| 2| 2| 2| 2| 0| 1| 2| 2| 2|
| 6| 0| 9| 9| 9| 8| 7| 9| 9| 9| 7| 0| 3| 9| 9| 6| 9| 9| 9| 9| 9| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + M +|
Parasite Metazoan | 2|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2 2 2 2|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X|
Eosinophilic Focus | |
Granuloma, Multiple | 1 1 1 1 1 1 1 1 1 3 1|
Hepatodiaphragmatic Nodule | 2 3 |
Mixed Cell Focus | X X |
Necrosis, Focal | |
Necrosis, Multifocal | |
Regeneration | 1 2 2 2 |
Vacuolization Cytoplasmic, Diffuse | 4 2 |
Biliary Tract, Proliferation | 1 1 1 1 1 1 1 2 2 1 1 2 |
Centrilobular, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis, Focal | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Acinus, Atrophy, Multifocal | 2 2 1 1 2 2 2 1 1 |
Acinus, Hyperplasia, Focal | |
Acinus, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 1 1 |
Acinus, Atrophy, Multifocal | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 2| 2| 5| 8| 2| 2| 2| 8| 1| 2| 2| 2| 8| 2| 2| 2| 2| 0| 1| 2| 2| 2|
| 6| 0| 9| 9| 9| 8| 7| 9| 9| 9| 7| 0| 3| 9| 9| 6| 9| 9| 9| 9| 9| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 1 2 1 1 2 2|
Inflammation, Focal, Subacute | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | 1 |
Degeneration, Fatty, Focal | 2 2 1|
Hyperplasia, Focal | 2 2 1 2 2 1 2 1|
Hypertrophy, Focal | |
Inflammation, Granulomatous, | |
Multifocal | |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 1 2 |
Hyperplasia, Multifocal | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 2 2 2 3 4 3 3 2 4 2 3 4 2 4|
Pars Distalis, Cyst | 1 2 1 2 1 1 4 2 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 1 2 2 3 3 3 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 1 2 2 1 1 1 1 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | 1 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 |
Inflammation, Subacute | 3 2 3 2 2 3 |
Duct, Cyst | 3 4 2 3 3 3 3 3 3|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X 3 |
Inflammation, Granulomatous, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 2| 2| 5| 8| 2| 2| 2| 8| 1| 2| 2| 2| 8| 2| 2| 2| 2| 0| 1| 2| 2| 2|
| 6| 0| 9| 9| 9| 8| 7| 9| 9| 9| 7| 0| 3| 9| 9| 6| 9| 9| 9| 9| 9| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 3 |
Cervix, Abscess | 4 3 4 4 |
Cervix, Cyst | 4 3 4 4 |
Endometrium, Hyperplasia, Cystic | 1 |
Mucosa, Cyst | |
Wall, Cervix, Hypertrophy | |
__________________________________________________________________________|
Vagina | + + + |
Wall, Hypertrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Infiltration Cellular, Histiocyte | 2 |
Myelofibrosis | 4 2 |
Pigmentation, Multifocal, Cholesterol| 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | 2 |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pancreatic, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 1 1 1 1 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 1 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
Cranium, Osteopetrosis | 3 2 2 |
Femur, Osteopetrosis | 4 2 2 |
Turbinate, Osteopetrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 9| 2| 2| 2| 5| 8| 2| 2| 2| 8| 1| 2| 2| 2| 8| 2| 2| 2| 2| 0| 1| 2| 2| 2|
| 6| 0| 9| 9| 9| 8| 7| 9| 9| 9| 7| 0| 3| 9| 9| 6| 9| 9| 9| 9| 9| 6| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 2|
Hydrocephalus | 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Granuloma, Multiple | 1|
Infiltration Cellular, Diffuse, | |
Histiocyte | 2 |
Pleura, Fibrosis, Focal | 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | 3 |
Inflammation, Acute, Suppurative | 3 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 1 1 1 1 1 1 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + |
Cataract | 4 3 4 4 3 2 2 3 2 4 2 |
Retina, Degeneration | 4 3 4 4 3 3 4 3 3 4 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Nephropathy, Chronic | 4 3 2 3 2 1 3 1 1 1 1 2 2 1 2 1 2 2 2 1 1 2 2 2|
Cortex, Cyst | |
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 |
Renal Tubule, Pigmentation, | |
Hemosiderin, Multifocal | 4 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 2| 2| 2| 3| 0| 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 4| 9| 9| 9| 9| 2| 4| 2| 9| 9| 7| 0| 9| 9| 9| 6| 3| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X |
Eosinophilic Focus | X |
Granuloma, Multiple | 2 2 1 2 1 3 1 1 1 2 1 2 1 1 1 2|
Hepatodiaphragmatic Nodule | 2 2 |
Mixed Cell Focus | X X |
Necrosis, Focal | 1 1 |
Necrosis, Multifocal | 1 |
Regeneration | 2 2 |
Vacuolization Cytoplasmic, Diffuse | 3 2 |
Biliary Tract, Proliferation | 1 1 2 2 1 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Acinus, Atrophy, Multifocal | 1 1 2 3 1 1 1 2 2 2 1 1 1 |
Acinus, Hyperplasia, Focal | 2 2 |
Acinus, Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 |
Acinus, Atrophy, Multifocal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 2| 2| 2| 3| 0| 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 4| 9| 9| 9| 9| 2| 4| 2| 9| 9| 7| 0| 9| 9| 9| 6| 3| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 1 1 1 2 1 1 2 1 2 2 1 3 1 1 1 2|
Inflammation, Focal, Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Degeneration, Fatty, Focal | 1 3 2 2 3 |
Hyperplasia, Focal | 2 2 1 1 2 1 2 1 2 2 |
Hypertrophy, Focal | 2 1 1 1 |
Inflammation, Granulomatous, | |
Multifocal | 1 |
Capsule, Accessory Adrenal Cortical | |
Nodule | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 1 1 1 |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 3 3 4 2 4 2 2 4 2 4 3 4 2 4 3 3 4 2|
Pars Distalis, Cyst | 2 2 2 3 2 2 2 2 2 2 2 2 1 2 4 2 1|
Pars Distalis, Hyperplasia, Focal | 2 3 3 2 3 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 1 2 2 1 2 1 2 2 2 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia, Focal | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + M M + +|
Hyperplasia | 2 2 1 1 |
Inflammation, Subacute | 2 3 2 |
Duct, Cyst | 3 2 3 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1|
Inflammation, Granulomatous, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 2| 2| 2| 3| 0| 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 4| 9| 9| 9| 9| 2| 4| 2| 9| 9| 7| 0| 9| 9| 9| 6| 3| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Cervix, Abscess | 4 |
Cervix, Cyst | 4 |
Endometrium, Hyperplasia, Cystic | |
Mucosa, Cyst | 2 2 2 |
Wall, Cervix, Hypertrophy | 3 |
__________________________________________________________________________|
Vagina | + + + + |
Wall, Hypertrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 |
Infiltration Cellular, Histiocyte | 1|
Myelofibrosis | |
Pigmentation, Multifocal, Cholesterol| 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Congestion | 1 |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pancreatic, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 1 2 1 1 1 1 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 4 4 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Cranium, Osteopetrosis | 3 2|
Femur, Osteopetrosis | 3 |
Turbinate, Osteopetrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 2| 2| 2| 3| 0| 2| 2| 2| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 4| 9| 9| 9| 9| 2| 4| 2| 9| 9| 7| 0| 9| 9| 9| 6| 3| 9| 9| 9| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Granuloma, Multiple | |
Infiltration Cellular, Diffuse, | |
Histiocyte | |
Pleura, Fibrosis, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2|
Fungus | 2|
Inflammation, Acute, Suppurative | 2|
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + +|
Cataract | 3 2 2 3 3 2|
Retina, Degeneration | 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 1 2 1 1 1 1 4 1 1 2 1 1 2 2 2 1 1 2 2 1 2 3 4 2 2|
Cortex, Cyst | 2 |
Papilla, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Pigmentation, | |
Hemosiderin, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
Parasite Metazoan | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Parasite Metazoan | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
Parasite Metazoan | | 10 2.0|
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 48 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | | 1 |
Basophilic Focus, Multiple | | 37 |
Eosinophilic Focus | | 1 |
Granuloma, Multiple | | 27 1.4|
Hepatodiaphragmatic Nodule | | 4 2.3|
Mixed Cell Focus | | 4 |
Necrosis, Focal | | 2 1.0|
Necrosis, Multifocal | | 1 1.0|
Regeneration | | 6 1.8|
Vacuolization Cytoplasmic, Diffuse | | 4 2.8|
Biliary Tract, Proliferation | | 18 1.3|
Centrilobular, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Fat, Necrosis, Focal | | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Basophilic Focus | | 1 |
Acinus, Atrophy, Multifocal | | 22 1.5|
Acinus, Hyperplasia, Focal | | 2 2.0|
Acinus, Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Acinus, Atrophy, Focal | | 4 1.3|
Acinus, Atrophy, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 33 1.3|
Inflammation, Focal, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Angiectasis | | 1 2.0|
Congestion | | 1 1.0|
Degeneration, Fatty, Focal | | 8 2.0|
Hyperplasia, Focal | | 18 1.6|
Hypertrophy, Focal | | 4 1.3|
Inflammation, Granulomatous, | | |
Multifocal | | 1 1.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 4 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 49 |
Hyperplasia, Focal | | 10 1.4|
Hyperplasia, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Angiectasis | | 35 3.0|
Pars Distalis, Cyst | | 26 2.0|
Pars Distalis, Hyperplasia, Focal | | 15 2.3|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 24 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia, Focal | | 8 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 47 |
Hyperplasia | | 7 2.1|
Inflammation, Subacute | | 9 2.4|
Duct, Cyst | | 14 2.8|
__________________________________________________________________________|____________|
Ovary | | 50 |
Cyst | | 5 2.0|
Inflammation, Granulomatous, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | | 50 |
Dilatation | | 3 2.3|
Cervix, Abscess | | 5 3.8|
Cervix, Cyst | | 5 3.8|
Endometrium, Hyperplasia, Cystic | | 1 1.0|
Mucosa, Cyst | | 3 2.0|
Wall, Cervix, Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | | 7 |
Wall, Hypertrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Hyperplasia | | 8 2.0|
Infiltration Cellular, Histiocyte | | 2 1.5|
Myelofibrosis | | 2 3.0|
Pigmentation, Multifocal, Cholesterol| | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Congestion | | 2 1.5|
Mesenteric, Hyperplasia, Macrophage, | | |
Multifocal | | 49 1.1|
Mesenteric, Pigmentation, Multifocal,| | |
Cholesterol | | 49 1.0|
Pancreatic, Ectasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Ectasia | | 21 1.1|
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrosis, Focal | | 2 1.5|
Hematopoietic Cell Proliferation | | 3 3.7|
Hyperplasia, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | | 3 1.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Skin | | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Fibrous Osteodystrophy | | 1 2.0|
Cranium, Osteopetrosis | | 5 2.4|
Femur, Osteopetrosis | | 4 2.8|
Turbinate, Osteopetrosis | | 2 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 4 2.0|
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 2.0|
Granuloma, Multiple | | 1 1.0|
Infiltration Cellular, Diffuse, | | |
Histiocyte | | 1 2.0|
Pleura, Fibrosis, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 2 2.0|
Fungus | | 2 2.5|
Inflammation, Acute, Suppurative | | 2 2.5|
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 19 1.1|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 17 |
Cataract | | 17 2.8|
Retina, Degeneration | | 17 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Hydronephrosis | | 1 2.0|
Nephropathy, Chronic | | 49 1.8|
Cortex, Cyst | | 1 2.0|
Papilla, Transitional Epithelium, | | |
Hyperplasia | | 1 1.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin, Multifocal | | 2 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 9| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Wall, Inflammation, Subacute | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + M + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic, Focal | 2 2 |
Degeneration, Cystic, Multifocal | 1 2 |
Eosinophilic Focus | X X X X X X X X |
Eosinophilic Focus, Multiple | X X |
Granuloma, Multiple | 1 1 2 2 1 3 2 2 1 1 1 1 1 2 2 3 2 1 1 1 2 2 2|
Hepatodiaphragmatic Nodule | 2 2 |
Mixed Cell Focus | |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X X X X X X X|
Necrosis, Multifocal | |
Pigmentation, Multifocal, Cholesterol| 1 1 1 1 1 2 1 1 1 1 1 2 2 2 1 1 1 1 1 1|
Vacuolization Cytoplasmic, Diffuse | |
Biliary Tract, Dilatation, Focal | 1 1 |
Biliary Tract, Proliferation | 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 2 |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Acinus, Atrophy, Multifocal | 3 1 2 1 2 2 2 2 1 2 2 2 1 2 1 2 2 2 2|
Duct, Hyperplasia | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 |
Acinus, Atrophy, Multifocal | 1 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 9| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 1 1 1 2 2 1 1 1 1 2 1 1 1 2|
Inflammation, Focal, Subacute | 1 |
Atrium, Thrombosis | |
Valve, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Degeneration, Fatty, Focal | 2 3 1 4 2 2 2 2 1 |
Hyperplasia, Focal | 1 1 3 1 1 1 1 2 2 2 2 1|
Hyperplasia, Multifocal | |
Hypertrophy, Focal | 2 1 2 2 1 |
Pigmentation, Multifocal, Cholesterol| 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 4 2 2 2 2 3 3 2 2 3 3|
Pars Distalis, Cyst | 1 2 2 2 2 2 2 1 3 2 2|
Pars Distalis, Hyperplasia, Focal | 1 2 2 1 1 2 2 3 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 1 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Focal, Cholesterol | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | 2 1 2 2 2 |
Follicle, Cyst | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 9| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 |
Inflammation, Subacute | 2 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 X 2 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 2 3|
Cervix, Abscess | 4 3 4 4 |
Cervix, Cyst | 4 3 4 4 |
Endometrium, Hyperplasia, Cystic | 2 |
Mucosa, Cyst | 3 2 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 4 |
Infiltration Cellular, Histiocyte | 2 1 |
Myelofibrosis | 1 |
Pigmentation, Multifocal, Cholesterol| 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 1 3 2 |
Mediastinal, Ectasia | 2 1 2 |
Mesenteric, Ectasia | 2 |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 2 1 2 2 1 2 1 3 2 2 2 2 2 4 2 1 2 1 2 2 2 2 2 2 3|
Mesenteric, Necrosis, Focal | |
Mesenteric, Necrosis, Multifocal | 2 2 2 |
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 2 1 2 1 2 1 1 2 2 2 2 2 2 4 2 1 2 2 2 2 2 2 2 2 2|
Pancreatic, Ectasia | 2 2 |
Pancreatic, Hyperplasia, Macrophage, | |
Multifocal | 2 |
Pancreatic, Pigmentation, Multifocal,| |
Cholesterol | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Ectasia | 1 1 1 1 1 2 2 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 1 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 9| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Artery, Mediastinum, Inflammation, | |
Subacute | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 3 3 3 3|
Femur, Osteopetrosis | 2 4 3 2 4 2 3 2 2|
Turbinate, Osteopetrosis | 4 2 4 4 3 3 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage, Multifocal | |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Diffuse, | |
Histiocyte | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 3 |
Mediastinum, Inflammation, Chronic | 2 |
Pleura, Congestion, Multifocal | 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | |
Inflammation, Acute, Suppurative | 1 |
Nasolacrimal Duct, Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 3 3 2 2 |
Anterior Chamber, Hemorrhage | 2 |
Retina, Degeneration | 4 4 3 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 1| 3| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 9| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hydronephrosis | |
Metaplasia, Focal, Osseous | |
Mineralization, Multifocal | |
Nephropathy, Chronic | 3 4 3 3 3 2 2 2 2 3 2 3 3 2 4 2 3 4 4 4 2 4 2 3 3|
Papilla, Necrosis | |
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 1 1 1 1 1 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Hemorrhage, Multifocal | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 8| 2| 3| 3|
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 3| 2| 3| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Wall, Inflammation, Subacute | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic, Focal | 2 |
Degeneration, Cystic, Multifocal | |
Eosinophilic Focus | X X X X X X |
Eosinophilic Focus, Multiple | |
Granuloma, Multiple | 2 2 2 1 3 1 1 1 2 2 2 1 2 1 2 1 2 1 3 1 1|
Hepatodiaphragmatic Nodule | 3 |
Mixed Cell Focus | X X X |
Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X X X X|
Necrosis, Multifocal | 1 |
Pigmentation, Multifocal, Cholesterol| 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Vacuolization Cytoplasmic, Diffuse | 2 |
Biliary Tract, Dilatation, Focal | 2 1 |
Biliary Tract, Proliferation | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | |
Fat, Necrosis, Focal | 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +|
Basophilic Focus | X |
Acinus, Atrophy, Multifocal | 4 3 2 3 4 2 2 3 1 3 2 2 2 3 2 1 2|
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 |
Acinus, Atrophy, Multifocal | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 8| 2| 3| 3|
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 3| 2| 3| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 2 1 1 1 2 2 2 2 1 1 1|
Inflammation, Focal, Subacute | 3 |
Atrium, Thrombosis | 4 |
Valve, Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration, Fatty, Focal | 1 1 1 1 3 1 |
Hyperplasia, Focal | 2 1 1 1 2 2 1 3 |
Hyperplasia, Multifocal | 2 |
Hypertrophy, Focal | 1 |
Pigmentation, Multifocal, Cholesterol| |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 2 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 4 3 2 2 4 2 3 3 3|
Pars Distalis, Cyst | 2 1 2 3 3 2 2 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 1 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Focal, Cholesterol | 2 |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia, Focal | 1 1 1 2 1 |
Follicle, Cyst | 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 8| 2| 3| 3|
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 3| 2| 3| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 3 |
Inflammation, Subacute | 2 |
Duct, Cyst | 2 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 3 3 3 |
Cervix, Abscess | 4 4 |
Cervix, Cyst | 4 4 |
Endometrium, Hyperplasia, Cystic | 2 2 |
Mucosa, Cyst | 2 2 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
Infiltration Cellular, Histiocyte | 2 1 |
Myelofibrosis | 2 |
Pigmentation, Multifocal, Cholesterol| 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 3 |
Mediastinal, Ectasia | |
Mesenteric, Ectasia | 1 1 |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2|
Mesenteric, Necrosis, Focal | 2 |
Mesenteric, Necrosis, Multifocal | 1 |
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 1 2 1 2|
Pancreatic, Ectasia | |
Pancreatic, Hyperplasia, Macrophage, | |
Multifocal | 3 |
Pancreatic, Pigmentation, Multifocal,| |
Cholesterol | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 1 1 1 2 2 1 1 1 1 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Fibrosis, Focal | 2 1 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | 2 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 8| 2| 3| 3|
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 3| 2| 3| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Artery, Mediastinum, Inflammation, | |
Subacute | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 3 |
Femur, Osteopetrosis | 3 3 |
Turbinate, Osteopetrosis | 4 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 2 |
Hemorrhage, Multifocal | 4 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Diffuse, | |
Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Mediastinum, Inflammation, Chronic | |
Pleura, Congestion, Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 2 2 |
Fungus | 3 3 3 3 |
Inflammation, Acute, Suppurative | 2 2 2 2 3 |
Nasolacrimal Duct, Foreign Body | 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 3 2 1 1 1 2 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + |
Cataract | 3 4 2 3 2 2 |
Anterior Chamber, Hemorrhage | |
Retina, Degeneration | 3 4 3 4 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 7| 3| 3| 3| 3| 7| 3| 3| 3| 3| 5| 8| 2| 3| 3|
| 0| 0| 0| 0| 0| 7| 7| 0| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 3| 2| 3| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +|
Fibrosis, Focal | 4 |
Hydronephrosis | 2 |
Metaplasia, Focal, Osseous | 2 |
Mineralization, Multifocal | 3 |
Nephropathy, Chronic | 3 3 2 4 1 4 3 4 3 3 2 3 4 3 3 3 3 3 1 2 2 4 3|
Papilla, Necrosis | 3 |
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 1 1 1 2 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Hemorrhage, Multifocal | 2 |
Mucosa, Hyperplasia | 4 2 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
Wall, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
Parasite Metazoan | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
Parasite Metazoan | | 8 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
Parasite Metazoan | | 6 2.0|
__________________________________________________________________________|____________|
Intestine Small | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 11 |
Basophilic Focus, Multiple | | 30 |
Clear Cell Focus | | 2 |
Degeneration, Cystic, Focal | | 3 2.0|
Degeneration, Cystic, Multifocal | | 2 1.5|
Eosinophilic Focus | | 14 |
Eosinophilic Focus, Multiple | | 2 |
Granuloma, Multiple | | 44 1.6|
Hepatodiaphragmatic Nodule | | 3 2.3|
Mixed Cell Focus | | 3 |
Mixed Cell Focus, Multiple | | 37 |
Necrosis, Multifocal | | 1 1.0|
Pigmentation, Multifocal, Cholesterol| | 41 1.1|
Vacuolization Cytoplasmic, Diffuse | | 1 2.0|
Biliary Tract, Dilatation, Focal | | 4 1.3|
Biliary Tract, Proliferation | | 29 1.1|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis, Focal | | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Basophilic Focus | | 2 |
Acinus, Atrophy, Multifocal | | 36 2.1|
Duct, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Acinus, Atrophy, Focal | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinus, Atrophy, Multifocal | | 6 1.2|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Mineralization | | 4 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 34 1.4|
Inflammation, Focal, Subacute | | 2 2.0|
Atrium, Thrombosis | | 1 4.0|
Valve, Inflammation, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Angiectasis | | 1 3.0|
Degeneration, Fatty, Focal | | 15 1.8|
Hyperplasia, Focal | | 20 1.6|
Hyperplasia, Multifocal | | 1 2.0|
Hypertrophy, Focal | | 6 1.5|
Pigmentation, Multifocal, Cholesterol| | 1 2.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 4 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia, Focal | | 11 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Angiectasis | | 26 2.6|
Pars Distalis, Cyst | | 19 2.1|
Pars Distalis, Hyperplasia, Focal | | 14 1.9|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 9 1.2|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pigmentation, Focal, Cholesterol | | 1 2.0|
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia, Focal | | 10 1.5|
Follicle, Cyst | | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 50 |
Hyperplasia | | 3 2.3|
Inflammation, Subacute | | 2 2.0|
Duct, Cyst | | 4 2.5|
__________________________________________________________________________|____________|
Ovary | | 50 |
Cyst | | 8 2.6|
__________________________________________________________________________|____________|
Uterus | | 50 |
Dilatation | | 9 2.7|
Cervix, Abscess | | 6 3.8|
Cervix, Cyst | | 6 3.8|
Endometrium, Hyperplasia, Cystic | | 3 2.0|
Mucosa, Cyst | | 6 2.2|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Hyperplasia | | 9 2.2|
Infiltration Cellular, Histiocyte | | 4 1.5|
Myelofibrosis | | 2 1.5|
Pigmentation, Multifocal, Cholesterol| | 4 1.5|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Congestion | | 4 2.3|
Mediastinal, Ectasia | | 3 1.7|
Mesenteric, Ectasia | | 3 1.3|
Mesenteric, Hyperplasia, Macrophage, | | |
Multifocal | | 48 1.9|
Mesenteric, Necrosis, Focal | | 1 2.0|
Mesenteric, Necrosis, Multifocal | | 4 1.8|
Mesenteric, Pigmentation, Multifocal,| | |
Cholesterol | | 48 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Ectasia | | 2 2.0|
Pancreatic, Hyperplasia, Macrophage, | | |
Multifocal | | 2 2.5|
Pancreatic, Pigmentation, Multifocal,| | |
Cholesterol | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Congestion | | 1 2.0|
Ectasia | | 21 1.2|
__________________________________________________________________________|____________|
Spleen | | 50 |
Atrophy | | 1 3.0|
Fibrosis, Focal | | 3 1.7|
Hematopoietic Cell Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | | 50 |
Atrophy | | 1 4.0|
Cyst | | 3 1.7|
Artery, Mediastinum, Inflammation, | | |
Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
__________________________________________________________________________|____________|
Skin | | 50 |
Inflammation, Acute, Focal, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Cranium, Osteopetrosis | | 7 2.9|
Femur, Osteopetrosis | | 11 2.7|
Turbinate, Osteopetrosis | | 9 3.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 3 1.7|
Hemorrhage, Multifocal | | 1 4.0|
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Infiltration Cellular, Diffuse, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocyte | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 3 2.3|
Mediastinum, Inflammation, Chronic | | 1 2.0|
Pleura, Congestion, Multifocal | | 3 1.7|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 5 2.0|
Fungus | | 4 3.0|
Inflammation, Acute, Suppurative | | 6 2.0|
Nasolacrimal Duct, Foreign Body | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 21 1.2|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 10 |
Cataract | | 10 2.6|
Anterior Chamber, Hemorrhage | | 1 2.0|
Retina, Degeneration | | 10 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Fibrosis, Focal | | 1 4.0|
Hydronephrosis | | 1 2.0|
Metaplasia, Focal, Osseous | | 1 2.0|
Mineralization, Multifocal | | 1 3.0|
Nephropathy, Chronic | | 48 2.9|
Papilla, Necrosis | | 1 3.0|
Papilla, Transitional Epithelium, | | |
Hyperplasia | | 12 1.1|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Calculus Micro Observation Only | | 1 |
Hemorrhage, Multifocal | | 1 2.0|
Mucosa, Hyperplasia | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.25% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 2 3 |
Basophilic Focus | X X X X X X X X X X X X|
Basophilic Focus, Multiple | X X X X X X X X X X X X |
Degeneration, Cystic, Focal | |
Degeneration, Cystic, Multifocal | 2 |
Eosinophilic Focus | X X X X X X X X|
Eosinophilic Focus, Multiple | X |
Granuloma, Multiple | 1 2 2 1 1 2 1 2 1 1 3 2 1 1 1 2 3 1 3 2 2|
Hepatodiaphragmatic Nodule | 3 X 3 3 2|
Mixed Cell Focus | X X X X X |
Mixed Cell Focus, Multiple | X X X X X X X X|
Pigmentation, Multifocal, Cholesterol| 2 2 1 1 1 1 1 1|
Vacuolization Cytoplasmic, Multifocal| |
Biliary Tract, Dilatation, Focal | 2 |
Biliary Tract, Proliferation | 1 1 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Fat, Necrosis, Focal | 3 3 4 4 3 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Acinus, Atrophy, Multifocal | 2 1 1 2 2 2 2 1 2 1 1 4 1 2 2 3 1 3|
Artery, Hypertrophy | 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + |
Acinus, Atrophy, Multifocal | 1 |
__________________________________________________________________________|
Stomach | + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
Hyperplasia | 2 |
Inflammation, Subacute | 2 |
Perforation | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + |
Erosion | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.25% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
Cardiomyopathy | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
Angiectasis | 3 |
Degeneration, Fatty, Focal | 2 4 |
Degeneration, Fatty, Multifocal | |
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + +|
Cyst | 1 |
Pars Distalis, Angiectasis | 2 3 3 3 2 2|
Pars Distalis, Cyst | 2 2|
Pars Distalis, Hyperplasia, Focal | 1 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + |
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + |
Hyperplasia | |
Duct, Cyst | 2 |
__________________________________________________________________________|
Ovary | + + + + + + |
Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + |
Dilatation | |
Cervix, Abscess | 3 4 4 4 |
Cervix, Cyst | 4 4 4 4 4 |
Mucosa, Cyst | 2 |
__________________________________________________________________________|
Vagina | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.25% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 2 1 1 2 |
Mediastinal, Ectasia | 2 1 |
Mesenteric, Ectasia | 2 |
Mesenteric, Fibrosis, Focal | 2 |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 1 2 2 2 2 1 1 2 2 2 2 2 2 1 2 1 3 2 2 2 2 1 2|
Mesenteric, Necrosis, Focal | 2 2 2 |
Mesenteric, Necrosis, Multifocal | |
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 1 2 2 2 2 2 1 2 1 1 2 2 2 1 1 1 2 1 2 2 2 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 1 2 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
Cranium, Osteopetrosis | |
Femur, Osteopetrosis | 3 |
Turbinate, Osteopetrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Multifocal | 2 |
__________________________________________________________________________|
Nose | + + + + + |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 |
__________________________________________________________________________|
Trachea | + + + + + |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 1| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.25% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + |
Cataract | 3 2 2 4 2 2 2 2 |
Retina, Degeneration | 3 3 3 4 3 4 4 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Nephropathy, Chronic | 1 2 2 2 2 2 2 3 2 3 2 3 2 2 3 3 2 3 2 3 2 2 3 3 3|
Artery, Inflammation, Subacute | 2 |
Papilla, Transitional Epithelium, | |
Hyperplasia | 2 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8| 3| 3| 3| 5| 9| 0| 3| 3| 9| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 0| 1| 1| 1| 3| 4| 8| 1| 1| 7| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | |
Basophilic Focus | X 2 X X X|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X |
Degeneration, Cystic, Focal | 2 2|
Degeneration, Cystic, Multifocal | |
Eosinophilic Focus | X X X X X|
Eosinophilic Focus, Multiple | X X X X |
Granuloma, Multiple | 1 2 2 2 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1|
Hepatodiaphragmatic Nodule | 3 X 3 3 2 3 3|
Mixed Cell Focus | X X X X X X X X |
Mixed Cell Focus, Multiple | X X X X X X X X X |
Pigmentation, Multifocal, Cholesterol| 1 1 2 1 1 1 |
Vacuolization Cytoplasmic, Multifocal| 1 |
Biliary Tract, Dilatation, Focal | 2 |
Biliary Tract, Proliferation | 2 2 2 2 2 2 2 1 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis, Focal | 3 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Acinus, Atrophy, Multifocal | 4 1 1 1 1 3 2 3 2 2 2 1 2 2 2 2 3 4 3 1 3 1|
Artery, Hypertrophy | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
Acinus, Atrophy, Multifocal | |
__________________________________________________________________________|
Stomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
Hyperplasia | 2 |
Inflammation, Subacute | 4 |
Perforation | 4 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
Erosion | 3 |
__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8| 3| 3| 3| 5| 9| 0| 3| 3| 9| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 0| 1| 1| 1| 3| 4| 8| 1| 1| 7| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Cardiomyopathy | 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Angiectasis | |
Degeneration, Fatty, Focal | 2 2 2 2 |
Degeneration, Fatty, Multifocal | 2 |
Hyperplasia, Focal | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + |
Cyst | |
Pars Distalis, Angiectasis | 3 3 3 2 3 2 |
Pars Distalis, Cyst | 2 2 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + |
Hyperplasia | 4 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + |
Cyst | 1 2 1 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + +|
Dilatation | 1 2 |
Cervix, Abscess | 2 3 3 4 3 3 3 4|
Cervix, Cyst | 4 3 4 4 3 3 3 4|
Mucosa, Cyst | |
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8| 3| 3| 3| 5| 9| 0| 3| 3| 9| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 0| 1| 1| 1| 3| 4| 8| 1| 1| 7| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 2 |
Mediastinal, Ectasia | 2 1 |
Mesenteric, Ectasia | 1 |
Mesenteric, Fibrosis, Focal | |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 2 1 2 1 1 2 1 2 1 2 1 1 1 1 1 2 2 2 2 2 2 1 1 2 1|
Mesenteric, Necrosis, Focal | |
Mesenteric, Necrosis, Multifocal | 2 |
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 2 2 1 2 1 1 1 2 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Ectasia | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
Cranium, Osteopetrosis | 2 1 2 |
Femur, Osteopetrosis | 2 2 |
Turbinate, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + |
Nasolacrimal Duct, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8| 3| 3| 3| 5| 9| 0| 3| 3| 9| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| 0| 1| 1| 1| 3| 4| 8| 1| 1| 7| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + |
Cataract | 4 3 4 3 4 |
Retina, Degeneration | 4 3 4 3 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Nephropathy, Chronic | 3 3 2 2 1 3 3 3 3 3 1 2 2 3 2 2 2 2 2 3 2 2 2 3 3|
Artery, Inflammation, Subacute | |
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 1|
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 9| 9| 9| 8| 8| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.25% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 12 |
__________________________________________________________________________|____________|
Intestine Large | | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 12 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 9 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Multifocal | | 2 2.5|
Basophilic Focus | | 17 2.0|
Basophilic Focus, Multiple | | 26 |
Degeneration, Cystic, Focal | | 2 2.0|
Degeneration, Cystic, Multifocal | | 1 2.0|
Eosinophilic Focus | | 13 |
Eosinophilic Focus, Multiple | | 5 |
Granuloma, Multiple | | 43 1.5|
Hepatodiaphragmatic Nodule | | 12 2.8|
Mixed Cell Focus | | 13 |
Mixed Cell Focus, Multiple | | 17 |
Pigmentation, Multifocal, Cholesterol| | 14 1.2|
Vacuolization Cytoplasmic, Multifocal| | 1 1.0|
Biliary Tract, Dilatation, Focal | | 2 2.0|
Biliary Tract, Proliferation | | 18 1.8|
__________________________________________________________________________|____________|
Mesentery | | 10 |
Fat, Necrosis, Focal | | 10 3.4|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Basophilic Focus | | 2 |
Acinus, Atrophy, Multifocal | | 40 2.0|
Artery, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 12 |
Acinus, Atrophy, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 12 |
Hyperplasia | | 2 2.0|
Inflammation, Subacute | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 9| 9| 9| 8| 8| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.25% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Perforation | | 1 4.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 12 |
Erosion | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 12 |
Cardiomyopathy | | 7 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 13 |
Angiectasis | | 1 3.0|
Degeneration, Fatty, Focal | | 6 2.3|
Degeneration, Fatty, Multifocal | | 1 2.0|
Hyperplasia, Focal | | 2 2.0|
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 13 |
Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | | 20 |
Cyst | | 1 1.0|
Pars Distalis, Angiectasis | | 12 2.6|
Pars Distalis, Cyst | | 6 2.0|
Pars Distalis, Hyperplasia, Focal | | 3 1.7|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 13 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia, Focal | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 14 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 9| 9| 9| 8| 8| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.25% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Cyst | | 2 2.5|
__________________________________________________________________________|____________|
Ovary | | 14 |
Cyst | | 5 2.4|
__________________________________________________________________________|____________|
Uterus | | 28 |
Dilatation | | 2 1.5|
Cervix, Abscess | | 12 3.3|
Cervix, Cyst | | 13 3.7|
Mucosa, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 12 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Congestion | | 7 1.7|
Mediastinal, Ectasia | | 4 1.5|
Mesenteric, Ectasia | | 2 1.5|
Mesenteric, Fibrosis, Focal | | 1 2.0|
Mesenteric, Hyperplasia, Macrophage, | | |
Multifocal | | 48 1.6|
Mesenteric, Necrosis, Focal | | 3 2.0|
Mesenteric, Necrosis, Multifocal | | 1 2.0|
Mesenteric, Pigmentation, Multifocal,| | |
Cholesterol | | 47 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Congestion | | 1 2.0|
Ectasia | | 18 1.1|
__________________________________________________________________________|____________|
Spleen | | 50 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
__________________________________________________________________________|____________|
Skin | | 33 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 16 |
Cranium, Osteopetrosis | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 9| 9| 9| 8| 8| 8| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.25% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Femur, Osteopetrosis | | 3 2.3|
Turbinate, Osteopetrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 13 |
Compression | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 2.0|
Hemorrhage, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 12 |
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 13 |
Cataract | | 13 2.8|
Retina, Degeneration | | 13 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Inflammation, Subacute | | 1 2.0|
Nephropathy, Chronic | | 50 2.4|
Artery, Inflammation, Subacute | | 1 2.0|
Papilla, Transitional Epithelium, | | |
Hyperplasia | | 4 1.3|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X|
Basophilic Focus, Multiple | X X X X X X X X X X X X X |
Degeneration, Cystic, Focal | 1 |
Eosinophilic Focus | X |
Granuloma, Multiple | 1 2 1 2 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | 2 3 2 |
Mixed Cell Focus | X X X X |
Mixed Cell Focus, Multiple | X X X|
Pigmentation, Multifocal, Cholesterol| 1 |
Vacuolization Cytoplasmic, Diffuse | 4 |
Biliary Tract, Proliferation | 2 2 2 2 2 2 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Granulomatous | 2 |
Fat, Necrosis, Focal | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Acinus, Atrophy, Multifocal | 3 3 1 1 2 3 2 2 3 2 1 2 1 3 2 1 2 2|
Artery, Inflammation, Subacute | |
__________________________________________________________________________|
Pharynx | + |
Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
Cardiomyopathy | 1 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + +|
Angiectasis | 3|
Degeneration, Fatty, Focal | |
Degeneration, Fatty, Multifocal | 2 3|
Hyperplasia, Focal | 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + |
Cyst | |
Pars Distalis, Angiectasis | 2 2 2 2 2 |
Pars Distalis, Cyst | 2 2 2 2 |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + |
Hyperplasia | |
Inflammation, Subacute | 2 2 |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + |
Dilatation | 2 |
Hemorrhage | |
Cervix, Abscess | 3 3 |
Cervix, Abscess, Multiple | |
Cervix, Cyst | 3 3 |
Cervix, Cyst, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 1 3 |
Mediastinal, Ectasia | 1 1 |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 2 2 2 1 1 1 2 1 2 1 1 1 1 1 2 1 1 1 1 1 2 2 1 1|
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Ectasia | 1 1 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + |
Cyst | |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + +|
Inflammation, Chronic | |
Femur, Osteopetrosis | 2 2|
Turbinate, Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Compression | 2 |
Hemorrhage, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin, Multifocal| 1 |
__________________________________________________________________________|
Nose | + + + + |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 4 2 2 |
Anterior Chamber, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Posterior Chamber, Hemorrhage | |
Retina, Degeneration | 4 3 3 |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Nephropathy, Chronic | 2 3 2 3 2 2 2 2 3 3 2 2 2 2 2 3 2 1 2 3 2 2 3 2 3|
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 5| 0| 3| 3| 3|
| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 7| 8| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 X X X |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X|
Degeneration, Cystic, Focal | |
Eosinophilic Focus | X X X X X X |
Granuloma, Multiple | 2 2 1 1 1 1 1 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | 3 3 2 |
Mixed Cell Focus | X X X X X X |
Mixed Cell Focus, Multiple | X X X |
Pigmentation, Multifocal, Cholesterol| 1 1 |
Vacuolization Cytoplasmic, Diffuse | |
Biliary Tract, Proliferation | 2 2 2 2 2 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + +|
Inflammation, Granulomatous | |
Fat, Necrosis, Focal | 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Acinus, Atrophy, Multifocal | 2 3 2 3 2 2 2 1 2 1 2 2 1 2 1 |
Artery, Inflammation, Subacute | 2|
__________________________________________________________________________|
Pharynx | + |
Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
Cardiomyopathy | 1 1 1 1 |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 5| 0| 3| 3| 3|
| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 7| 8| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + +|
Angiectasis | |
Degeneration, Fatty, Focal | 2 |
Degeneration, Fatty, Multifocal | 3 |
Hyperplasia, Focal | 2 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + +|
Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + +|
Cyst | 2 |
Pars Distalis, Angiectasis | 2 2 2 2 2 2 2 2 3 3|
Pars Distalis, Cyst | 2 2 2 2 2 2 |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia, Focal | 2 3 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + +|
Hyperplasia | 3 2|
Inflammation, Subacute | 3 |
Duct, Cyst | 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + |
Cyst | 2 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | 2 |
Cervix, Abscess | 4 4 4|
Cervix, Abscess, Multiple | 4 |
Cervix, Cyst | 4 4 4|
Cervix, Cyst, Multiple | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 5| 0| 3| 3| 3|
| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 7| 8| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Ectasia | 1 |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 1 2 2 1 2 2 2 2 1 1 1 2 2 1 1 2 1 2 2 1 1 1 1 1|
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 1 2 2 1 2 2 1 1 1 2 2 2 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 1 1 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 4 |
__________________________________________________________________________|
Thymus | + + + + + + +|
Cyst | 3|
Inflammation, Subacute | 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
Inflammation, Chronic | 4 |
Femur, Osteopetrosis | 2 |
Turbinate, Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Compression | |
Hemorrhage, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin, Multifocal| |
__________________________________________________________________________|
Nose | + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + +|
Cataract | 2 2 3 3 2 4 2 2 2|
Anterior Chamber, Hemorrhage | 2 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 5| 0| 3| 3| 3|
| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 7| 8| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Posterior Chamber, Hemorrhage | 2 |
Retina, Degeneration | 3 3 3 2 4 3 3 4|
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Nephropathy, Chronic | 3 2 2 2 2 2 2 2 3 3 2 2 2 3 2 2 2 3 2 1 3 2 2 3|
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 9| 9| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 9 |
__________________________________________________________________________|____________|
Intestine Large | | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 10 |
Parasite Metazoan | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 10 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 9 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 11 2.0|
Basophilic Focus, Multiple | | 29 |
Degeneration, Cystic, Focal | | 1 1.0|
Eosinophilic Focus | | 7 |
Granuloma, Multiple | | 21 1.2|
Hepatodiaphragmatic Nodule | | 6 2.5|
Mixed Cell Focus | | 10 |
Mixed Cell Focus, Multiple | | 6 |
Pigmentation, Multifocal, Cholesterol| | 3 1.0|
Vacuolization Cytoplasmic, Diffuse | | 1 4.0|
Biliary Tract, Proliferation | | 12 2.0|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Inflammation, Granulomatous | | 1 2.0|
Fat, Necrosis, Focal | | 6 3.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Basophilic Focus | | 1 |
Acinus, Atrophy, Multifocal | | 33 1.9|
Artery, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 2 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 10 |
__________________________________________________________________________|____________|
Stomach | | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 9 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 9 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Dysplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 9| 9| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 10 |
Cardiomyopathy | | 6 1.0|
Atrium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 16 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 16 |
Angiectasis | | 1 3.0|
Degeneration, Fatty, Focal | | 1 2.0|
Degeneration, Fatty, Multifocal | | 3 2.7|
Hyperplasia, Focal | | 3 2.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 16 |
Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | | 22 |
Cyst | | 1 2.0|
Pars Distalis, Angiectasis | | 15 2.1|
Pars Distalis, Cyst | | 10 2.0|
Pars Distalis, Hemorrhage | | 2 2.5|
Pars Distalis, Hyperplasia, Focal | | 5 2.2|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | | 12 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 14 |
Hyperplasia | | 2 2.5|
Inflammation, Subacute | | 3 2.3|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | | 14 |
Cyst | | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 9| 9| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | | 23 |
Dilatation | | 2 2.5|
Hemorrhage | | 1 2.0|
Cervix, Abscess | | 5 3.6|
Cervix, Abscess, Multiple | | 1 4.0|
Cervix, Cyst | | 5 3.6|
Cervix, Cyst, Multiple | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 10 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Congestion | | 2 2.0|
Mediastinal, Ectasia | | 3 1.0|
Mesenteric, Hyperplasia, Macrophage, | | |
Multifocal | | 48 1.4|
Mesenteric, Pigmentation, Multifocal,| | |
Cholesterol | | 45 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Congestion | | 1 2.0|
Ectasia | | 17 1.1|
__________________________________________________________________________|____________|
Spleen | | 50 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | | 11 |
Cyst | | 1 3.0|
Inflammation, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
__________________________________________________________________________|____________|
Skin | | 26 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 15 |
Inflammation, Chronic | | 1 4.0|
Femur, Osteopetrosis | | 3 2.0|
Turbinate, Osteopetrosis | | 2 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 9| 9| 8| 8| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | | 10 |
Compression | | 1 2.0|
Hemorrhage, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Pigmentation, Hemosiderin, Multifocal| | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 10 |
__________________________________________________________________________|____________|
Trachea | | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 12 |
Cataract | | 12 2.5|
Anterior Chamber, Hemorrhage | | 2 2.0|
Posterior Chamber, Hemorrhage | | 1 2.0|
Retina, Degeneration | | 11 3.2|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Inflammation, Subacute | | 1 2.0|
Nephropathy, Chronic | | 49 2.3|
Papilla, Transitional Epithelium, | | |
Hyperplasia | | 5 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 6| 0| 2| 2| 2| 1| 6| 0| 2| 2| 5| 5| 2| 2| 2| 3| 6| 2| 2| 2| 5| 1| 4| 6| 2|
| 6| 0| 9| 9| 9| 0| 6| 6| 9| 9| 3| 8| 9| 9| 9| 4| 6| 9| 9| 9| 3| 1| 4| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + M + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 1 |
Angiectasis, Multifocal | |
Basophilic Focus | X X X X X X X|
Basophilic Focus, Multiple | X |
Clear Cell Focus | X|
Degeneration, Cystic, Focal | 1 2 1 2|
Degeneration, Cystic, Multifocal | |
Eosinophilic Focus | X X|
Eosinophilic Focus, Multiple | |
Fibrosis | |
Granuloma, Multiple | 1 1 1 1 1 1 1 1 1 1 1 1 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 2 |
Mixed Cell Focus | X |
Pigmentation, Hemosiderin | |
Pigmentation, Multifocal, Cholesterol| |
Regeneration | 2 2 3 2 2 2 1 |
Thrombosis | 3 |
Biliary Tract, Proliferation | 1 3 1 1 1 3 2 3 2 3 3 2 2 3 2 2 4 2 2 3 1 2 3 2|
__________________________________________________________________________|
Mesentery | + + + + + +|
Fat, Inflammation, Chronic, | |
Multifocal | 2 |
Fat, Necrosis, Focal | 4 4|
Fat, Necrosis, Multifocal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Acinus, Atrophy, Multifocal | 1 3 1 1 2 1 2 2 2 1 3 |
Acinus, Hyperplasia, Focal | |
Acinus, Hyperplasia, Multifocal | |
Artery, Inflammation, Subacute | |
Duct, Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 6| 0| 2| 2| 2| 1| 6| 0| 2| 2| 5| 5| 2| 2| 2| 3| 6| 2| 2| 2| 5| 1| 4| 6| 2|
| 6| 0| 9| 9| 9| 0| 6| 6| 9| 9| 3| 8| 9| 9| 9| 4| 6| 9| 9| 9| 3| 1| 4| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Multiple | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Tongue | |
Foreign Body, Multiple | |
Granuloma, Multiple | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 1 1 1 2 2 2 2 2 2 1 1 2 1 1|
Fibrosis, Focal | 2 |
Inflammation, Multifocal, Subacute | 2 |
Mineralization, Multifocal | 1 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 1 1 1 3 1 2 |
Degeneration, Fatty, Multifocal | 2 |
Hyperplasia, Focal | 1 1 1 |
Hyperplasia, Multifocal | 1 2|
Necrosis, Multifocal | 3 |
Capsule, Accessory Adrenal Cortical | |
Nodule | |
Capsule, Hemorrhage | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 2 1 1 1 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 4 3 3 2 3 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 2 2 2|
Pars Distalis, Pigmentation, | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 6| 0| 2| 2| 2| 1| 6| 0| 2| 2| 5| 5| 2| 2| 2| 3| 6| 2| 2| 2| 5| 1| 4| 6| 2|
| 6| 0| 9| 9| 9| 0| 6| 6| 9| 9| 3| 8| 9| 9| 9| 4| 6| 9| 9| 9| 3| 1| 4| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hemosiderin | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 2 |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 2 |
Inflammation | 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 4 3 2 |
Inflammation, Subacute | 2 4 2 |
Duct, Cyst | X 3 3 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 1 1 2 1 1 1 2 1 1 1 1 2 2 2 3 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 2 |
Mineralization | |
Interstitial Cell, Hyperplasia, | |
Multifocal | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 3 4 2|
Myelofibrosis | 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | 2 |
Mediastinal, Ectasia | |
Mediastinal, Pigmentation, | |
Hemosiderin | 4 |
Mesenteric, Congestion | |
Mesenteric, Ectasia | 2 |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 2 1 1 2 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 6| 0| 2| 2| 2| 1| 6| 0| 2| 2| 5| 5| 2| 2| 2| 3| 6| 2| 2| 2| 5| 1| 4| 6| 2|
| 6| 0| 9| 9| 9| 0| 6| 6| 9| 9| 3| 8| 9| 9| 9| 4| 6| 9| 9| 9| 3| 1| 4| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pancreatic, Ectasia | |
Pancreatic, Hyperplasia, Macrophage, | |
Multifocal | |
Pancreatic, Pigmentation, Multifocal,| |
Cholesterol | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 1 1 1 1 1 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 1 2 2 2 |
Fibrosis, Multifocal | 2 |
Hematopoietic Cell Proliferation | 4 |
Infiltration Cellular, Lipocyte | 1 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + M + M + + +|
Cyst | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Duct, Cyst | 3 3 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Subcutaneous Tissue, Abscess, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 6| 0| 2| 2| 2| 1| 6| 0| 2| 2| 5| 5| 2| 2| 2| 3| 6| 2| 2| 2| 5| 1| 4| 6| 2|
| 6| 0| 9| 9| 9| 0| 6| 6| 9| 9| 3| 8| 9| 9| 9| 4| 6| 9| 9| 9| 3| 1| 4| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | 2 2 2 2 |
Fungus | 3 3 3 3 3 |
Inflammation, Acute, Suppurative | 2 2 3 3 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 1 1 3 2 1 1 1 1 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + |
Cataract | 4 2 3 3 4 4 4 |
Lids, Fibrosis, Focal | |
Posterior Chamber, Hemorrhage | 3 |
Retina, Degeneration | 4 4 4 3 3 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Metaplasia, Osseous | 2 |
Nephropathy, Chronic | 2 2 3 2 3 1 4 2 3 2 2 2 2 2 2 2 3 2 4 3 2 2 2 2 2|
Cortex, Cyst | 3 |
Cortex, Cyst, Multiple | 2 |
Papilla, Necrosis | 2 |
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 1 1 1 1 |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Mineralization, | |
Multifocal | 1 |
__________________________________________________________________________|
Urethra | + + |
Bulbourethral Gland, Congestion | 2 |
Bulbourethral Gland, Dilatation | 2 2 |
Bulbourethral Gland, Inflammation, | |
Subacute | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 8| 2| 2| 6| 2| 3| 3| 3| 3| 0| 2| 3| 3|
| 0| 6| 9| 9| 9| 1| 9| 9| 9| 9| 7| 8| 1| 9| 9| 3| 9| 2| 2| 2| 7| 0| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 1 1 1 |
Angiectasis, Multifocal | 2 1 2 |
Basophilic Focus | X X X X X X X X X X X|
Basophilic Focus, Multiple | X X |
Clear Cell Focus | X |
Degeneration, Cystic, Focal | 2 1 2 |
Degeneration, Cystic, Multifocal | 2 2 |
Eosinophilic Focus | X X X |
Eosinophilic Focus, Multiple | X |
Fibrosis | 3 |
Granuloma, Multiple | 1 1 1 2 2 1 1 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 2 |
Mixed Cell Focus | X |
Pigmentation, Hemosiderin | 4 |
Pigmentation, Multifocal, Cholesterol| 3 |
Regeneration | 2 2 1 1 2 1 2 1 2 |
Thrombosis | |
Biliary Tract, Proliferation | 2 3 1 2 3 2 1 2 2 3 2 1 2 4 3 1 3 3 2 2 1 4 3 3 2|
__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Inflammation, Chronic, | |
Multifocal | |
Fat, Necrosis, Focal | 4 4 3 |
Fat, Necrosis, Multifocal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Acinus, Atrophy, Multifocal | 3 2 1 1 2 1 3 1 1 1 1 3 2|
Acinus, Hyperplasia, Focal | 1 |
Acinus, Hyperplasia, Multifocal | 3 |
Artery, Inflammation, Subacute | 2|
Duct, Cyst | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 8| 2| 2| 6| 2| 3| 3| 3| 3| 0| 2| 3| 3|
| 0| 6| 9| 9| 9| 1| 9| 9| 9| 9| 7| 8| 1| 9| 9| 3| 9| 2| 2| 2| 7| 0| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Multiple | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Tongue | + |
Foreign Body, Multiple | 2 |
Granuloma, Multiple | 2 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 3 3 1 1 2 1 1 2 1 1 2 1 1 1|
Fibrosis, Focal | |
Inflammation, Multifocal, Subacute | |
Mineralization, Multifocal | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 2 2 2 1 3 |
Degeneration, Fatty, Multifocal | 2 |
Hyperplasia, Focal | 1 2 1 2 2 |
Hyperplasia, Multifocal | |
Necrosis, Multifocal | |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 1 |
Capsule, Hemorrhage | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 2 1 2 1 2 1 1 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 3 3 2 2 2 3 2 2 4 3 2 |
Pars Distalis, Cyst | 2 2 2 X |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Distalis, Pigmentation, | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 8| 2| 2| 6| 2| 3| 3| 3| 3| 0| 2| 3| 3|
| 0| 6| 9| 9| 9| 1| 9| 9| 9| 9| 7| 8| 1| 9| 9| 3| 9| 2| 2| 2| 7| 0| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hemosiderin | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Dilatation | |
Inflammation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Subacute | 2 2 |
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 1 1 2 3 2 2 1 1 2 2 2 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 2 2 |
Mineralization | 2 |
Interstitial Cell, Hyperplasia, | |
Multifocal | 1 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 1 3 2 3 2 2 3 2 2 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Congestion | 3 |
Mediastinal, Ectasia | 2 2 2 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mesenteric, Congestion | 3 2 |
Mesenteric, Ectasia | |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 8| 2| 2| 6| 2| 3| 3| 3| 3| 0| 2| 3| 3|
| 0| 6| 9| 9| 9| 1| 9| 9| 9| 9| 7| 8| 1| 9| 9| 3| 9| 2| 2| 2| 7| 0| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pancreatic, Ectasia | 3 |
Pancreatic, Hyperplasia, Macrophage, | |
Multifocal | 1 |
Pancreatic, Pigmentation, Multifocal,| |
Cholesterol | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Ectasia | 2 2 2 2 1 1 2 2 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 3 |
Fibrosis, Multifocal | |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lipocyte | |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + M + + + + + + + + M + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
Duct, Cyst | 2 2 2 2 4 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Subcutaneous Tissue, Abscess, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 4 |
Hemorrhage, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 9| 1| 2| 2| 2| 2| 2| 2| 2| 2| 8| 5| 8| 2| 2| 6| 2| 3| 3| 3| 3| 0| 2| 3| 3|
| 0| 6| 9| 9| 9| 1| 9| 9| 9| 9| 7| 8| 1| 9| 9| 3| 9| 2| 2| 2| 7| 0| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | 2 2 2 2 2 |
Fungus | 3 2 3 1 2 3 2 |
Inflammation, Acute, Suppurative | 2 2 3 2 2 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + +|
Cataract | 3 3 2 2 3 3|
Lids, Fibrosis, Focal | 3 3 |
Posterior Chamber, Hemorrhage | |
Retina, Degeneration | 4 3 4 4 4 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Metaplasia, Osseous | |
Nephropathy, Chronic | 2 2 3 2 3 3 3 3 4 2 2 3 2 2 3 2 2 3 3 2 3 3 2 2 2|
Cortex, Cyst | |
Cortex, Cyst, Multiple | X |
Papilla, Necrosis | |
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 1 |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Mineralization, | |
Multifocal | |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Congestion | |
Bulbourethral Gland, Dilatation | |
Bulbourethral Gland, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 49 |
Parasite Metazoan | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Parasite Metazoan | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
Parasite Metazoan | | 9 2.0|
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Focal | | 5 1.2|
Angiectasis, Multifocal | | 3 1.7|
Basophilic Focus | | 18 |
Basophilic Focus, Multiple | | 3 |
Clear Cell Focus | | 2 |
Degeneration, Cystic, Focal | | 7 1.6|
Degeneration, Cystic, Multifocal | | 2 2.0|
Eosinophilic Focus | | 5 |
Eosinophilic Focus, Multiple | | 1 |
Fibrosis | | 1 3.0|
Granuloma, Multiple | | 20 1.1|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | | 2 2.0|
Mixed Cell Focus | | 2 |
Pigmentation, Hemosiderin | | 1 4.0|
Pigmentation, Multifocal, Cholesterol| | 1 3.0|
Regeneration | | 16 1.8|
Thrombosis | | 1 3.0|
Biliary Tract, Proliferation | | 49 2.2|
__________________________________________________________________________|____________|
Mesentery | | 11 |
Fat, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
Fat, Necrosis, Focal | | 5 3.8|
Fat, Necrosis, Multifocal | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Basophilic Focus | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinus, Atrophy, Multifocal | | 24 1.7|
Acinus, Hyperplasia, Focal | | 1 1.0|
Acinus, Hyperplasia, Multifocal | | 1 3.0|
Artery, Inflammation, Subacute | | 1 2.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Ulcer, Multiple | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Foreign Body, Multiple | | 1 2.0|
Granuloma, Multiple | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 40 1.6|
Fibrosis, Focal | | 1 2.0|
Inflammation, Multifocal, Subacute | | 1 2.0|
Mineralization, Multifocal | | 1 1.0|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Degeneration, Fatty, Focal | | 11 1.7|
Degeneration, Fatty, Multifocal | | 2 2.0|
Hyperplasia, Focal | | 8 1.4|
Hyperplasia, Multifocal | | 2 1.5|
Necrosis, Multifocal | | 1 3.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 2 1.5|
Capsule, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia, Focal | | 22 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 48 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Angiectasis | | 18 2.8|
Pars Distalis, Cyst | | 5 2.0|
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | | 5 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia, Focal | | 4 1.8|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Dilatation | | 1 2.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | | 50 |
Inflammation, Subacute | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | | 49 |
Hyperplasia | | 4 2.8|
Inflammation, Subacute | | 5 2.4|
Duct, Cyst | | 5 2.8|
__________________________________________________________________________|____________|
Prostate | | 50 |
Inflammation, Subacute | | 31 1.6|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Dilatation | | 2 2.5|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Atrophy | | 10 2.1|
Mineralization | | 1 2.0|
Interstitial Cell, Hyperplasia, | | |
Multifocal | | 5 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Hyperplasia | | 19 2.5|
Myelofibrosis | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Congestion | | 2 2.5|
Mediastinal, Ectasia | | 4 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 4.0|
Mesenteric, Congestion | | 2 2.5|
Mesenteric, Ectasia | | 1 2.0|
Mesenteric, Hyperplasia, Macrophage, | | |
Multifocal | | 50 1.1|
Mesenteric, Pigmentation, Multifocal,| | |
Cholesterol | | 50 1.0|
Pancreatic, Ectasia | | 1 3.0|
Pancreatic, Hyperplasia, Macrophage, | | |
Multifocal | | 1 1.0|
Pancreatic, Pigmentation, Multifocal,| | |
Cholesterol | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Congestion | | 1 1.0|
Ectasia | | 16 1.5|
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrosis, Focal | | 6 2.0|
Fibrosis, Multifocal | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Infiltration Cellular, Lipocyte | | 1 1.0|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 44 |
Cyst | | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Hyperplasia | | 5 2.0|
Duct, Cyst | | 13 2.5|
__________________________________________________________________________|____________|
Skin | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Focal | | 1 3.0|
Subcutaneous Tissue, Abscess, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Fibrous Osteodystrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 3 3.0|
Hemorrhage, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 9 2.0|
Fungus | | 12 2.6|
Inflammation, Acute, Suppurative | | 13 2.2|
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 13 1.3|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 15 |
Cataract | | 13 3.1|
Lids, Fibrosis, Focal | | 2 3.0|
Posterior Chamber, Hemorrhage | | 1 3.0|
Retina, Degeneration | | 13 3.8|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Hydronephrosis | | 1 2.0|
Metaplasia, Osseous | | 1 2.0|
Nephropathy, Chronic | | 50 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cortex, Cyst | | 1 3.0|
Cortex, Cyst, Multiple | | 2 2.0|
Papilla, Necrosis | | 1 2.0|
Papilla, Transitional Epithelium, | | |
Hyperplasia | | 7 1.0|
Renal Tubule, Hyperplasia | | 2 1.5|
Renal Tubule, Mineralization, | | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Urethra | | 2 |
Bulbourethral Gland, Congestion | | 1 2.0|
Bulbourethral Gland, Dilatation | | 2 2.0|
Bulbourethral Gland, Inflammation, | | |
Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 8| 8| 1| 3| 3| 2| 9| 3| 3| 3| 1| 2| 2| 3| 3| 9| 1| 3| 3| 3| 7| 1| 5| 8| 0|
| 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 8| 3| 9| 0| 0| 0| 6| 0| 0| 0| 7| 2| 5| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2 2 |
Lymphoid Tissue, Inflammation, | |
Subacute | 2 |
Lymphoid Tissue, Mineralization | 2 |
Wall, Mineralization | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +|
Parasite Metazoan | 2 |
Wall, Mineralization | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + + + + + + + + + + +|
Lymphoid Tissue, Inflammation, | |
Subacute | 2 |
Lymphoid Tissue, Mineralization | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Multifocal, Subacute | |
Necrosis, Multifocal | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 2 2 3 2 2 2 2 1 2 2 2 2 3|
Basophilic Focus | X X X X X X |
Clear Cell Focus | X X |
Congestion | 2 2 |
Cyst | 1 |
Degeneration, Cystic, Multifocal | 2 3 3 3 3 2 3 1 4 2 2 1 2 3 1 2 3 3|
Eosinophilic Focus | X X X X |
Eosinophilic Focus, Multiple | X X X X X X X X X X X X X X X X X|
Granuloma, Multiple | 2 1 1 2 2 2 1 2 1 2 1 2 2 1 |
Hepatodiaphragmatic Nodule | 2 2 2 |
Mixed Cell Focus | X |
Mixed Cell Focus, Multiple | X X X |
Necrosis, Focal | 1 |
Pigmentation, Multifocal, Cholesterol| |
Vacuolization Cytoplasmic, Diffuse | 2 |
Biliary Tract, Cyst | 2 2 |
Biliary Tract, Proliferation | 3 2 3 2 1 3 3 2 3 2 2 3 3 2 2 2 1 2 2 2 2 2 3 3 3|
Centrilobular, Necrosis | 2|
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 8| 8| 1| 3| 3| 2| 9| 3| 3| 3| 1| 2| 2| 3| 3| 9| 1| 3| 3| 3| 7| 1| 5| 8| 0|
| 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 8| 3| 9| 0| 0| 0| 6| 0| 0| 0| 7| 2| 5| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 |
Acinus, Atrophy, Multifocal | 2 1 1 3 2 2 2 1 2 4 2 1 3 2 1 2 2 3 3 2 1 3 3|
Acinus, Hyperplasia, Focal | |
Artery, Hypertrophy | |
Artery, Inflammation, Subacute | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Multifocal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Hyperplasia | 2 |
Inflammation, Subacute | 2 4 2 |
Mineralization | 2 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 2 3 1 3 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
Abdominal, Hypertrophy | 3 |
Abdominal, Inflammation, Subacute | |
Abdominal, Mineralization | 4 3 3 |
Abdominal, Thrombosis | |
Aorta, Mineralization | 4 3 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 1 2 3 2 2 2 2 2 2 2 3 1 3 2 2 2 2 2 3 3 2|
Fibrosis, Focal | 2 |
Mineralization, Multifocal | 2 3 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration, Fatty, Focal | 1 1 1 2 1 2 1 |
Degeneration, Fatty, Multifocal | 2 |
Hyperplasia, Focal | 2 2 2 2 2 2 1 4 |
Inflammation, Granulomatous, | |
Multifocal | 2 |
Pigmentation, Multifocal, Cholesterol| 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 2 2 2 2 2 1 1 1 2 2 3|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 8| 8| 1| 3| 3| 2| 9| 3| 3| 3| 1| 2| 2| 3| 3| 9| 1| 3| 3| 3| 7| 1| 5| 8| 0|
| 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 8| 3| 9| 0| 0| 0| 6| 0| 0| 0| 7| 2| 5| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Multifocal | 2 1 2 2 |
Thrombosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 2 3 1 2 3 2 3 3 1 1 4 2 3 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 3 4 |
Pars Distalis, Cyst | X 2 1 |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 1 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | 2 |
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia, Focal | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hyperplasia | 1 |
Inflammation, Subacute | 1 |
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 4 1 3 1 1 2 1 2 1 1 2 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 3 2 |
Interstitial Cell, Hyperplasia, | |
Multifocal | 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 3 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 2 2 2 2|
Mediastinal, Hyperplasia, Macrophage,| |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 8| 8| 1| 3| 3| 2| 9| 3| 3| 3| 1| 2| 2| 3| 3| 9| 1| 3| 3| 3| 7| 1| 5| 8| 0|
| 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 8| 3| 9| 0| 0| 0| 6| 0| 0| 0| 7| 2| 5| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Congestion | 2 3 |
Mesenteric, Ectasia | 2 2 2 |
Mesenteric, Fibrosis, Focal | |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 2 1 3 1 2 2 2 1 3 1 1 2 1 1 2 2 2 1 1 2 2 2 1 2 2|
Mesenteric, Necrosis, Focal | 2 |
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 2 1 1 1 2 1 1 1 3 2 1 2 1 1 2 2 2 1 2 2 2 2 2 2 2|
Pancreatic, Ectasia | 2 |
Pancreatic, Hyperplasia, Macrophage, | |
Multifocal | 2 2 2 |
Pancreatic, Pigmentation, Multifocal,| |
Cholesterol | 2 2 2 |
Renal, Hyperplasia, Macrophage, | |
Multifocal | 2 |
Renal, Pigmentation, Multifocal, | |
Cholesterol | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Ectasia | 2 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 3 |
Infiltration Cellular, Lipocyte | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 |
Inflammation, Chronic | |
Duct, Cyst | 4 2 2 2 2 |
Duct, Inflammation, Subacute | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 4 2 2 4 3 1 3 3 2 3 3 1 1 4 2 3 3|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7|
DAY ON TEST | 8| 8| 1| 3| 3| 2| 9| 3| 3| 3| 1| 2| 2| 3| 3| 9| 1| 3| 3| 3| 7| 1| 5| 8| 0|
| 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 8| 3| 9| 0| 0| 0| 6| 0| 0| 0| 7| 2| 5| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Pleura, Congestion, Multifocal | 2 |
Pleura, Fibrosis, Focal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 2 |
Fungus | 3 3 3 3 3 2 2 3 |
Inflammation, Acute, Suppurative | 2 2 2 1 2 2 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 1 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + +|
__________________________________________________________________________|
Eye | + + + + + + + + + |
Cataract | 2 4 4 3 3 4 3 |
Retina, Degeneration | 2 2 4 4 3 4 4 4 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
Inflammation, Acute, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 2 4 4 4 4 4 4 4 3 4 4 4 4 4 3 4 4 4 4 3 4 4 3 4 4|
Cortex, Cyst | 2 2 |
Cortex, Cyst, Multiple | 2 2 2 1 2 2 2 |
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 2 2 2 1 1 1 1 2 1 1 2 1 2 2 2 2 1 1 1 1 2 1|
Renal Tubule, Hyperplasia | 1 1 1 |
Renal Tubule, Mineralization, | |
Multifocal | 3 3 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 6| 4| 7| 8| 3| 6| 2| 2| 2| 3| 8| 1| 2| 5| 3| 0| 1| 3| 3| 3| 5| 7| 9| 1| 2|
| 7| 3| 9| 2| 0| 6| 3| 9| 9| 0| 1| 2| 4| 8| 0| 5| 0| 0| 0| 0| 8| 8| 4| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
Lymphoid Tissue, Inflammation, | |
Subacute | |
Lymphoid Tissue, Mineralization | |
Wall, Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
Wall, Mineralization | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Inflammation, | |
Subacute | |
Lymphoid Tissue, Mineralization | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Multifocal, Subacute | 2 |
Necrosis, Multifocal | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 1 2 1 2 2|
Basophilic Focus | X |
Clear Cell Focus | |
Congestion | |
Cyst | |
Degeneration, Cystic, Multifocal | 2 2 2 3 3 3 3 2 2 3 2 3 2 3 2 1 2 3|
Eosinophilic Focus | |
Eosinophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X X|
Granuloma, Multiple | 1 2 2 2 2 2 1 1 1 1 2 2 2 |
Hepatodiaphragmatic Nodule | 2 2 |
Mixed Cell Focus | X X X X X X |
Mixed Cell Focus, Multiple | X X X X X |
Necrosis, Focal | |
Pigmentation, Multifocal, Cholesterol| 1 |
Vacuolization Cytoplasmic, Diffuse | |
Biliary Tract, Cyst | |
Biliary Tract, Proliferation | 3 2 3 3 2 3 2 2 2 3 2 2 2 2 2 2 3 2 3 2 3 2 3 3 2|
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 6| 4| 7| 8| 3| 6| 2| 2| 2| 3| 8| 1| 2| 5| 3| 0| 1| 3| 3| 3| 5| 7| 9| 1| 2|
| 7| 3| 9| 2| 0| 6| 3| 9| 9| 0| 1| 2| 4| 8| 0| 5| 0| 0| 0| 0| 8| 8| 4| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Acinus, Atrophy, Multifocal | 3 1 1 1 2 2 2 2 3 3 3 2 2 2 2 1 1 2|
Acinus, Hyperplasia, Focal | 2 2 1 2 |
Artery, Hypertrophy | 3 |
Artery, Inflammation, Subacute | 2 2 2 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Multifocal | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + M + + + + + + +|
Edema | |
Hyperplasia | |
Inflammation, Subacute | |
Mineralization | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Mineralization | 3 2 2 1 2 1 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
Abdominal, Hypertrophy | 3 3 3 |
Abdominal, Inflammation, Subacute | 3 |
Abdominal, Mineralization | 3 |
Abdominal, Thrombosis | 3 |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 2 3 2 2 1 2 3 2 2 3 1 2 2 1 2 3 2 3|
Fibrosis, Focal | |
Mineralization, Multifocal | 2 2 1 |
Atrium, Thrombosis | 4 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Degeneration, Fatty, Focal | 2 1 1 2 2 1 2 1 |
Degeneration, Fatty, Multifocal | |
Hyperplasia, Focal | 1 2 2 2 2 1 2 2|
Inflammation, Granulomatous, | |
Multifocal | |
Pigmentation, Multifocal, Cholesterol| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 6| 4| 7| 8| 3| 6| 2| 2| 2| 3| 8| 1| 2| 5| 3| 0| 1| 3| 3| 3| 5| 7| 9| 1| 2|
| 7| 3| 9| 2| 0| 6| 3| 9| 9| 0| 1| 2| 4| 8| 0| 5| 0| 0| 0| 0| 8| 8| 4| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Multifocal | 1 |
Thrombosis | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 3 2 2 3 3 3 1 3 2 1 1 2 3 1 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 3 |
Pars Distalis, Cyst | X 2 1 2 1 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | 3 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Hyperplasia | |
Inflammation, Subacute | 1 1 2 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 1 2 1 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3|
Interstitial Cell, Hyperplasia, | |
Multifocal | 1 2 1 1 2 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 2 2 2 |
Mediastinal, Hyperplasia, Macrophage,| |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 6| 4| 7| 8| 3| 6| 2| 2| 2| 3| 8| 1| 2| 5| 3| 0| 1| 3| 3| 3| 5| 7| 9| 1| 2|
| 7| 3| 9| 2| 0| 6| 3| 9| 9| 0| 1| 2| 4| 8| 0| 5| 0| 0| 0| 0| 8| 8| 4| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Congestion | |
Mesenteric, Ectasia | |
Mesenteric, Fibrosis, Focal | 2 2 |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 2 1 2 2 1 2 2 1 2 2 2 1 3 3 1 2 3 2 2 2 1 2 2 2|
Mesenteric, Necrosis, Focal | 2 |
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 2 1 2 2 1 2 2 1 2 2 1 2 3 2 1 2 3 2 2 2 1 2 2 2|
Pancreatic, Ectasia | |
Pancreatic, Hyperplasia, Macrophage, | |
Multifocal | 2 2 |
Pancreatic, Pigmentation, Multifocal,| |
Cholesterol | 2 2 |
Renal, Hyperplasia, Macrophage, | |
Multifocal | |
Renal, Pigmentation, Multifocal, | |
Cholesterol | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 1 2 2 2 1 1 3 1 2 1 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Fibrosis, Focal | 2 3 3 1 3 3 3 |
Infiltration Cellular, Lipocyte | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M M + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Chronic | 3 |
Duct, Cyst | X 1 1 4 2 2 |
Duct, Inflammation, Subacute | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 3 4 2 3 4 4 3 1 2 4 2 1 1 3 2 1 3|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 6| 4| 7| 8| 3| 6| 2| 2| 2| 3| 8| 1| 2| 5| 3| 0| 1| 3| 3| 3| 5| 7| 9| 1| 2|
| 7| 3| 9| 2| 0| 6| 3| 9| 9| 0| 1| 2| 4| 8| 0| 5| 0| 0| 0| 0| 8| 8| 4| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | 4 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 3 |
Pleura, Congestion, Multifocal | |
Pleura, Fibrosis, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 |
Fungus | 2 2 3 3 |
Inflammation, Acute, Suppurative | 2 2 2 4 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 2 1 2 2 2 1 3 2 2 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 4 3 |
Retina, Degeneration | 3 4 3 |
__________________________________________________________________________|
Zymbal's Gland | + + |
Inflammation, Acute, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hydronephrosis | 2 2 |
Nephropathy, Chronic | 4 3 4 4 4 4 4 4 4 4 4 4 3 3 4 3 4 4 4 4 4 3 4 4|
Cortex, Cyst | |
Cortex, Cyst, Multiple | 2 1 2 2 2 1 2 2 |
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
Renal Tubule, Hyperplasia | 1 1 1 1 |
Renal Tubule, Mineralization, | |
Multifocal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 1| 6| 6| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
Parasite Metazoan | | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Parasite Metazoan | | 6 2.0|
Lymphoid Tissue, Inflammation, | | |
Subacute | | 1 2.0|
Lymphoid Tissue, Mineralization | | 1 2.0|
Wall, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
Parasite Metazoan | | 4 2.0|
Wall, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 49 |
Lymphoid Tissue, Inflammation, | | |
Subacute | | 1 2.0|
Lymphoid Tissue, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 49 |
Inflammation, Multifocal, Subacute | | 1 2.0|
Necrosis, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Multifocal | | 29 2.0|
Basophilic Focus | | 7 |
Clear Cell Focus | | 2 |
Congestion | | 2 2.0|
Cyst | | 1 1.0|
Degeneration, Cystic, Multifocal | | 36 2.4|
Eosinophilic Focus | | 4 |
Eosinophilic Focus, Multiple | | 37 |
Granuloma, Multiple | | 27 1.6|
Hepatodiaphragmatic Nodule | | 5 2.0|
Mixed Cell Focus | | 7 |
Mixed Cell Focus, Multiple | | 8 |
Necrosis, Focal | | 1 1.0|
Pigmentation, Multifocal, Cholesterol| | 1 1.0|
Vacuolization Cytoplasmic, Diffuse | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 1| 6| 6| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Biliary Tract, Cyst | | 2 2.0|
Biliary Tract, Proliferation | | 50 2.4|
Centrilobular, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Fat, Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Basophilic Focus | | 1 1.0|
Acinus, Atrophy, Multifocal | | 41 2.0|
Acinus, Hyperplasia, Focal | | 4 1.8|
Artery, Hypertrophy | | 1 3.0|
Artery, Inflammation, Subacute | | 3 2.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Acinus, Atrophy, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Edema | | 2 2.0|
Hyperplasia | | 1 2.0|
Inflammation, Subacute | | 3 2.7|
Mineralization | | 1 2.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
Mineralization | | 16 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 7 |
Abdominal, Hypertrophy | | 4 3.0|
Abdominal, Inflammation, Subacute | | 1 3.0|
Abdominal, Mineralization | | 4 3.3|
Abdominal, Thrombosis | | 1 3.0|
Aorta, Mineralization | | 4 3.5|
__________________________________________________________________________|____________|
Heart | | 50 |
Cardiomyopathy | | 45 2.1|
Fibrosis, Focal | | 1 2.0|
Mineralization, Multifocal | | 5 2.0|
Atrium, Thrombosis | | 4 3.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 1| 6| 6| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Cyst | | 1 2.0|
Degeneration, Fatty, Focal | | 15 1.4|
Degeneration, Fatty, Multifocal | | 1 2.0|
Hyperplasia, Focal | | 16 1.9|
Inflammation, Granulomatous, | | |
Multifocal | | 1 2.0|
Pigmentation, Multifocal, Cholesterol| | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia, Focal | | 21 1.9|
Hyperplasia, Multifocal | | 5 1.6|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
Hyperplasia | | 34 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Angiectasis | | 7 3.1|
Pars Distalis, Cyst | | 8 1.5|
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | | 8 1.9|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Inflammation, Acute, Suppurative | | 1 2.0|
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia, Focal | | 5 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
Granuloma Sperm | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 50 |
Foreign Body | | 1 2.0|
Hyperplasia | | 1 1.0|
Inflammation, Subacute | | 4 1.3|
Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 1| 6| 6| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Subacute | | 22 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Inflammation, Subacute | | 1 1.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Atrophy | | 7 2.1|
Interstitial Cell, Hyperplasia, | | |
Multifocal | | 10 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Hyperplasia | | 19 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Congestion | | 9 2.0|
Mediastinal, Hyperplasia, Macrophage,| | |
Multifocal | | 1 1.0|
Mesenteric, Congestion | | 2 2.5|
Mesenteric, Ectasia | | 3 2.0|
Mesenteric, Fibrosis, Focal | | 2 2.0|
Mesenteric, Hyperplasia, Macrophage, | | |
Multifocal | | 49 1.8|
Mesenteric, Necrosis, Focal | | 2 2.0|
Mesenteric, Pigmentation, Multifocal,| | |
Cholesterol | | 49 1.7|
Pancreatic, Ectasia | | 1 2.0|
Pancreatic, Hyperplasia, Macrophage, | | |
Multifocal | | 5 2.0|
Pancreatic, Pigmentation, Multifocal,| | |
Cholesterol | | 5 2.0|
Renal, Hyperplasia, Macrophage, | | |
Multifocal | | 1 2.0|
Renal, Pigmentation, Multifocal, | | |
Cholesterol | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Congestion | | 1 2.0|
Ectasia | | 20 1.5|
__________________________________________________________________________|____________|
Spleen | | 49 |
Fibrosis, Focal | | 9 2.7|
Infiltration Cellular, Lipocyte | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 1| 6| 6| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 48 |
Hyperplasia | | 5 1.4|
Inflammation, Chronic | | 1 3.0|
Duct, Cyst | | 11 2.2|
Duct, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Hyperplasia, Focal | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Fibrous Osteodystrophy | | 36 2.6|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 3.0|
Pleura, Congestion, Multifocal | | 1 2.0|
Pleura, Fibrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 7 2.0|
Fungus | | 12 2.7|
Inflammation, Acute, Suppurative | | 13 2.1|
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 22 1.5|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 1| 6| 6| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cataract | | 10 3.3|
Retina, Degeneration | | 12 3.3|
__________________________________________________________________________|____________|
Zymbal's Gland | | 3 |
Inflammation, Acute, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Hydronephrosis | | 2 2.0|
Nephropathy, Chronic | | 49 3.8|
Cortex, Cyst | | 2 2.0|
Cortex, Cyst, Multiple | | 15 1.8|
Papilla, Transitional Epithelium, | | |
Hyperplasia | | 43 1.3|
Renal Tubule, Hyperplasia | | 7 1.0|
Renal Tubule, Mineralization, | | |
Multifocal | | 4 3.3|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 7| 9| 3| 3| 9| 3| 3| 3| 3| 8| 1| 1| 3| 3| 7| 8| 2| 3| 3| 2| 9| 0| 3| 3|
| 0| 6| 5| 0| 0| 8| 0| 0| 0| 0| 7| 0| 8| 1| 1| 6| 2| 2| 1| 1| 9| 0| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + |
Parasite Metazoan | 2 |
Artery, Inflammation, Subacute | |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 1 |
Angiectasis, Multifocal | 1 2 2 2 1 2 2 1|
Basophilic Focus | X X X|
Basophilic Focus, Multiple | X |
Clear Cell Focus | X |
Congestion | 2 |
Cyst | |
Degeneration, Cystic, Focal | 1 2 |
Degeneration, Cystic, Multifocal | 2 2 2 2 2 1 2 3 3 2 3 2 1 1 3 2 2|
Eosinophilic Focus | X X X X X X X X |
Eosinophilic Focus, Multiple | X X X X X X X X|
Fibrosis | |
Granuloma | |
Granuloma, Multiple | 3 1 1 1 1 1 2 1 1 2 2 1 1 1 1 1 1|
Hepatodiaphragmatic Nodule | 3 |
Hepatodiaphragmatic Nodule, Multiple,| |
Two | |
Inflammation, Subacute | 3 |
Mixed Cell Focus | X X X X X X|
Mixed Cell Focus, Multiple | X X |
Necrosis, Multifocal | 2 2 |
Pigmentation, Hemosiderin | 2 |
Regeneration | |
Biliary Tract, Proliferation | 3 2 2 2 3 3 2 3 3 2 2 2 2 2 2 3 2 3 2 2 3 2 2 2 2|
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Acinus, Atrophy, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 7| 9| 3| 3| 9| 3| 3| 3| 3| 8| 1| 1| 3| 3| 7| 8| 2| 3| 3| 2| 9| 0| 3| 3|
| 0| 6| 5| 0| 0| 8| 0| 0| 0| 0| 7| 0| 8| 1| 1| 6| 2| 2| 1| 1| 9| 0| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Atrophy, Multifocal | 1 2 2 2 1 1 3 3 1 1 4 2 3 1 3 1 2|
Acinus, Hyperplasia, Focal | 2 2 2 |
Duct, Cyst | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + |
Acinus, Hyperplasia, Multifocal | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + |
Edema | 3 2 |
Erosion | 2 |
Hyperplasia | 2 2 |
Inflammation, Subacute | 2 2 2 |
Perforation | |
Ulcer, Multiple | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + |
Edema | 3 2 |
Inflammation, Subacute | 2 1 |
Mineralization | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Abdominal, Hypertrophy | |
Abdominal, Inflammation, Subacute | |
Abdominal, Mineralization | 2 |
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + |
Cardiomyopathy | 2 1 2 2 2 2 1 2 3 3 1 2 3 |
Fibrosis, Focal | |
Mineralization, Multifocal | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 1 1 1 1 1 2 |
Degeneration, Fatty, Multifocal | 1 3 2 |
Hyperplasia, Focal | 2 1 1 2 1 3 2 2 1 1|
Hyperplasia, Multifocal | 1 2 |
Inflammation, Granulomatous, | |
Multifocal | |
Pigmentation, Multifocal, Cholesterol| |
Capsule, Accessory Adrenal Cortical | |
Nodule | 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 7| 9| 3| 3| 9| 3| 3| 3| 3| 8| 1| 1| 3| 3| 7| 8| 2| 3| 3| 2| 9| 0| 3| 3|
| 0| 6| 5| 0| 0| 8| 0| 0| 0| 0| 7| 0| 8| 1| 1| 6| 2| 2| 1| 1| 9| 0| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Multifocal | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + I + |
Hyperplasia | 2 2 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 3 3 2 2 1 |
Pars Distalis, Cyst | X 2 2 X |
Pars Distalis, Hemorrhage | 3 3 |
Pars Distalis, Hyperplasia, Focal | 1 |
Pars Distalis, Necrosis | 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + |
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia, Focal | 1 |
Follicle, Cyst | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + |
Inflammation, Subacute | 2 2 2 |
Duct, Cyst | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + |
Inflammation, Subacute | 2 2 2 2 2 2 2 3 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + |
Hyperplasia, Focal | |
Inflammation, Subacute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 2 2 |
Hemorrhage | 2 |
Mineralization | 2 |
Interstitial Cell, Hyperplasia, | |
Multifocal | 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | 2 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Congestion | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 7| 9| 3| 3| 9| 3| 3| 3| 3| 8| 1| 1| 3| 3| 7| 8| 2| 3| 3| 2| 9| 0| 3| 3|
| 0| 6| 5| 0| 0| 8| 0| 0| 0| 0| 7| 0| 8| 1| 1| 6| 2| 2| 1| 1| 9| 0| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Axillary, Ectasia | |
Mediastinal, Amyloid Deposition | |
Mediastinal, Congestion | |
Mediastinal, Ectasia | 2 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mesenteric, Ectasia | 2 2 |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 1 1 1 2 1 2 2 2 1 1 2 3 1 3 2 1 3 2 1 2 2 1 1 1|
Mesenteric, Necrosis, Focal | 2 2 |
Mesenteric, Necrosis, Multifocal | |
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 1 1 1 2 1 2 2 2 1 1 2 3 1 1 1 1 3 2 1 1 2 1 1 1|
Pancreatic, Hyperplasia, Macrophage, | |
Multifocal | 2 2 |
Pancreatic, Pigmentation, Multifocal,| |
Cholesterol | 2 2 |
Renal, Congestion | |
Renal, Hyperplasia, Macrophage, | |
Multifocal | |
Renal, Pigmentation, Multifocal, | |
Cholesterol | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Ectasia | 3 2 2 2 1 1 1 2 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 3 3 2 |
Fibrosis, Multifocal | 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + |
Hyperplasia | 2 |
Duct, Cyst | 1 1 2 2 2 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Multifocal | |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | |
Inflammation, Multifocal, Subacute | |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 7| 9| 3| 3| 9| 3| 3| 3| 3| 8| 1| 1| 3| 3| 7| 8| 2| 3| 3| 2| 9| 0| 3| 3|
| 0| 6| 5| 0| 0| 8| 0| 0| 0| 0| 7| 0| 8| 1| 1| 6| 2| 2| 1| 1| 9| 0| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + |
Fibrous Osteodystrophy | 2 3 1 2 |
Cranium, Hypertrophy, Focal | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + |
Compression | 2 2 |
Hemorrhage, Multifocal | 2 3 2 |
Necrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + |
Foreign Body | 2 2 2 2 2 |
Fungus | 3 3 2 2 2 3 |
Hyperkeratosis | |
Inflammation, Acute, Suppurative | 1 3 2 2 2 2 3 |
Nasolacrimal Duct, Foreign Body | 1 |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 3 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + |
Cataract | 3 3 2 2 2 3 3 3 |
Anterior Chamber, Hemorrhage | 3 |
Anterior Chamber, Inflammation, | |
Acute, Suppurative | 3 |
Conjunctiva, Inflammation, Acute, | |
Suppurative | 3 |
Cornea, Inflammation, Acute, | |
Suppurative | 2 |
Cornea, Inflammation, Subacute | 2 |
Posterior Chamber, Hemorrhage | |
Retina, Degeneration | 3 3 2 3 3 3 3 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 2 3 4 4 3 4 4 4 4 4 3 4 4 4 3 4 4 4 4 3 4 4 3 4|
Cortex, Cyst | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 7| 9| 3| 3| 9| 3| 3| 3| 3| 8| 1| 1| 3| 3| 7| 8| 2| 3| 3| 2| 9| 0| 3| 3|
| 0| 6| 5| 0| 0| 8| 0| 0| 0| 0| 7| 0| 8| 1| 1| 6| 2| 2| 1| 1| 9| 0| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cortex, Cyst, Multiple | 2 2 2 |
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1|
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Hyperplasia | 1 1 |
Renal Tubule, Mineralization, | |
Multifocal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 7| 7| 3| 3| 3| 1| 8| 3| 3| 3| 0| 1| 1| 3| 3|
| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 5| 8| 1| 1| 1| 0| 2| 1| 1| 1| 8| 0| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + A + + + A |
Parasite Metazoan | |
Artery, Inflammation, Subacute | 3 |
Artery, Necrosis, Fibrinoid | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + A + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 2 |
Angiectasis, Multifocal | 2 1 2 2 2 2 2 2 2 2 2 2 2 |
Basophilic Focus | X X X X X X X X X |
Basophilic Focus, Multiple | |
Clear Cell Focus | X |
Congestion | |
Cyst | 3 |
Degeneration, Cystic, Focal | 2 2 2 |
Degeneration, Cystic, Multifocal | 2 3 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2|
Eosinophilic Focus | X X X X X X |
Eosinophilic Focus, Multiple | X X X X X X X X X X X X X X|
Fibrosis | 2 |
Granuloma | 1 |
Granuloma, Multiple | 1 1 1 1 1 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | 3 2 2 2 |
Hepatodiaphragmatic Nodule, Multiple,| |
Two | 2 |
Inflammation, Subacute | |
Mixed Cell Focus | X X X X X X X X X|
Mixed Cell Focus, Multiple | X X X X |
Necrosis, Multifocal | 1 2 |
Pigmentation, Hemosiderin | |
Regeneration | 1 |
Biliary Tract, Proliferation | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 3 2 2 2 2 2 3 2 2|
Centrilobular, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +|
Basophilic Focus | X X X |
Acinus, Atrophy, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 7| 7| 3| 3| 3| 1| 8| 3| 3| 3| 0| 1| 1| 3| 3|
| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 5| 8| 1| 1| 1| 0| 2| 1| 1| 1| 8| 0| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Atrophy, Multifocal | 2 2 2 4 2 1 2 2 2 2 1 3 4 2 1 1 2 2 2 3|
Acinus, Hyperplasia, Focal | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + |
Acinus, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + |
Edema | 2 |
Erosion | |
Hyperplasia | |
Inflammation, Subacute | 4 2 |
Perforation | 4 |
Ulcer, Multiple | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + |
Edema | |
Inflammation, Subacute | |
Mineralization | 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
Abdominal, Hypertrophy | 4 2 |
Abdominal, Inflammation, Subacute | 3 |
Abdominal, Mineralization | |
Aorta, Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + |
Cardiomyopathy | 3 2 3 2 3 3 2 3 4 |
Fibrosis, Focal | 3 |
Mineralization, Multifocal | 2 |
Atrium, Thrombosis | 3 3 3 3 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 2 1 1 2 2 |
Degeneration, Fatty, Multifocal | 2 |
Hyperplasia, Focal | 2 1 1 3 |
Hyperplasia, Multifocal | 1 2 |
Inflammation, Granulomatous, | |
Multifocal | 2 2 |
Pigmentation, Multifocal, Cholesterol| 1 1 |
Capsule, Accessory Adrenal Cortical | |
Nodule | X 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 3 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 7| 7| 3| 3| 3| 1| 8| 3| 3| 3| 0| 1| 1| 3| 3|
| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 5| 8| 1| 1| 1| 0| 2| 1| 1| 1| 8| 0| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + |
Hyperplasia | 2 1 2 4 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Necrosis | 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Inflammation, Subacute | |
Duct, Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + |
Inflammation, Subacute | 2 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
Hyperplasia, Focal | 2 |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 3 1 |
Hemorrhage | |
Mineralization | |
Interstitial Cell, Hyperplasia, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 7| 7| 3| 3| 3| 1| 8| 3| 3| 3| 0| 1| 1| 3| 3|
| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 5| 8| 1| 1| 1| 0| 2| 1| 1| 1| 8| 0| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Axillary, Ectasia | 2 |
Mediastinal, Amyloid Deposition | 3 |
Mediastinal, Congestion | 2 2 2 3 2 2 |
Mediastinal, Ectasia | 2 2 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 |
Mesenteric, Ectasia | 2 2 2 |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 1 1 1 2 2 2 1 2 3 1 1 1 2 1 1 2 2 2 1 1 1 2 2 2|
Mesenteric, Necrosis, Focal | |
Mesenteric, Necrosis, Multifocal | 1 |
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 1 1 1 2 2 1 1 2 3 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1|
Pancreatic, Hyperplasia, Macrophage, | |
Multifocal | 3 |
Pancreatic, Pigmentation, Multifocal,| |
Cholesterol | 2 |
Renal, Congestion | 2 |
Renal, Hyperplasia, Macrophage, | |
Multifocal | 2 |
Renal, Pigmentation, Multifocal, | |
Cholesterol | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 2 1 1 1 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 3 3 1 |
Fibrosis, Multifocal | |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + |
Hyperplasia | 2 |
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Multifocal | 4 |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | 4 |
Inflammation, Multifocal, Subacute | 3 |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 7| 7| 3| 3| 3| 1| 8| 3| 3| 3| 0| 1| 1| 3| 3|
| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 5| 8| 1| 1| 1| 0| 2| 1| 1| 1| 8| 0| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
Fibrous Osteodystrophy | 2 2 2 2 |
Cranium, Hypertrophy, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + |
Compression | |
Hemorrhage, Multifocal | 3 |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + |
Foreign Body | 2 2 |
Fungus | 3 3 3 |
Hyperkeratosis | 2 |
Inflammation, Acute, Suppurative | 2 3 2 |
Nasolacrimal Duct, Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + |
Cataract | 2 3 4 4 4 4 |
Anterior Chamber, Hemorrhage | 3 |
Anterior Chamber, Inflammation, | |
Acute, Suppurative | |
Conjunctiva, Inflammation, Acute, | |
Suppurative | |
Cornea, Inflammation, Acute, | |
Suppurative | |
Cornea, Inflammation, Subacute | |
Posterior Chamber, Hemorrhage | 3 |
Retina, Degeneration | 2 3 4 4 4 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 4 3 3 4 3 3 3 4 4 3 2 4 4 4 3 4 4 3 4 4 4 4 4 4|
Cortex, Cyst | 3 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 0| 3| 3| 3| 3| 7| 7| 3| 3| 3| 1| 8| 3| 3| 3| 0| 1| 1| 3| 3|
| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 5| 8| 1| 1| 1| 0| 2| 1| 1| 1| 8| 0| 4| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cortex, Cyst, Multiple | 2 2 1 2 |
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 4 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Mineralization, | |
Multifocal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 7| 7| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 22 |
__________________________________________________________________________|____________|
Intestine Large | | 22 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 19 |
Parasite Metazoan | | 1 2.0|
Artery, Inflammation, Subacute | | 1 3.0|
Artery, Necrosis, Fibrinoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 22 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 22 |
__________________________________________________________________________|____________|
Intestine Small | | 22 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 21 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 19 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 20 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Focal | | 4 1.8|
Angiectasis, Multifocal | | 21 1.8|
Basophilic Focus | | 12 |
Basophilic Focus, Multiple | | 1 |
Clear Cell Focus | | 2 |
Congestion | | 1 2.0|
Cyst | | 1 3.0|
Degeneration, Cystic, Focal | | 5 1.8|
Degeneration, Cystic, Multifocal | | 35 2.1|
Eosinophilic Focus | | 14 |
Eosinophilic Focus, Multiple | | 22 |
Fibrosis | | 1 2.0|
Granuloma | | 1 1.0|
Granuloma, Multiple | | 27 1.2|
Hepatodiaphragmatic Nodule | | 5 2.4|
Hepatodiaphragmatic Nodule, Multiple,| | |
Two | | 1 2.0|
Inflammation, Subacute | | 1 3.0|
Mixed Cell Focus | | 15 |
Mixed Cell Focus, Multiple | | 6 |
Necrosis, Multifocal | | 4 1.8|
Pigmentation, Hemosiderin | | 1 2.0|
Regeneration | | 1 1.0|
Biliary Tract, Proliferation | | 49 2.2|
Centrilobular, Necrosis | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 7| 7| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mesentery | | 6 |
Fat, Necrosis, Focal | | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Basophilic Focus | | 6 |
Acinus, Atrophy, Focal | | 2 1.0|
Acinus, Atrophy, Multifocal | | 37 2.0|
Acinus, Hyperplasia, Focal | | 3 2.0|
Duct, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 22 |
Acinus, Hyperplasia, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | | 22 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 22 |
Edema | | 3 2.3|
Erosion | | 1 2.0|
Hyperplasia | | 2 2.0|
Inflammation, Subacute | | 5 2.4|
Perforation | | 1 4.0|
Ulcer, Multiple | | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | | 22 |
Edema | | 2 2.5|
Inflammation, Subacute | | 2 1.5|
Mineralization | | 5 2.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 5 |
Abdominal, Hypertrophy | | 2 3.0|
Abdominal, Inflammation, Subacute | | 1 3.0|
Abdominal, Mineralization | | 1 2.0|
Aorta, Mineralization | | 2 3.0|
__________________________________________________________________________|____________|
Heart | | 27 |
Cardiomyopathy | | 22 2.3|
Fibrosis, Focal | | 1 3.0|
Mineralization, Multifocal | | 2 2.0|
Atrium, Thrombosis | | 5 3.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Degeneration, Fatty, Focal | | 11 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 7| 7| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Degeneration, Fatty, Multifocal | | 4 2.0|
Hyperplasia, Focal | | 14 1.6|
Hyperplasia, Multifocal | | 4 1.5|
Inflammation, Granulomatous, | | |
Multifocal | | 2 2.0|
Pigmentation, Multifocal, Cholesterol| | 2 1.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 5 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia, Focal | | 9 1.7|
Hyperplasia, Multifocal | | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 21 |
Hyperplasia | | 9 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | | 25 |
Pars Distalis, Angiectasis | | 6 2.3|
Pars Distalis, Cyst | | 5 2.0|
Pars Distalis, Hemorrhage | | 2 3.0|
Pars Distalis, Hyperplasia, Focal | | 2 1.5|
Pars Distalis, Necrosis | | 2 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | | 23 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia, Focal | | 1 1.0|
Follicle, Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 23 |
__________________________________________________________________________|____________|
Preputial Gland | | 25 |
Inflammation, Subacute | | 3 2.0|
Duct, Cyst | | 2 |
__________________________________________________________________________|____________|
Prostate | | 22 |
Inflammation, Subacute | | 15 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 22 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 7| 7| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 48 |
Atrophy | | 8 2.0|
Hemorrhage | | 1 2.0|
Mineralization | | 1 2.0|
Interstitial Cell, Hyperplasia, | | |
Multifocal | | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukocytosis | | 1 2.0|
__________________________________________________________________________|____________|
Bone Marrow | | 22 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Axillary, Congestion | | 1 2.0|
Axillary, Ectasia | | 1 2.0|
Mediastinal, Amyloid Deposition | | 1 3.0|
Mediastinal, Congestion | | 6 2.2|
Mediastinal, Ectasia | | 5 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 2.0|
Mesenteric, Ectasia | | 5 2.0|
Mesenteric, Hyperplasia, Macrophage, | | |
Multifocal | | 48 1.6|
Mesenteric, Necrosis, Focal | | 2 2.0|
Mesenteric, Necrosis, Multifocal | | 1 1.0|
Mesenteric, Pigmentation, Multifocal,| | |
Cholesterol | | 48 1.4|
Pancreatic, Hyperplasia, Macrophage, | | |
Multifocal | | 3 2.3|
Pancreatic, Pigmentation, Multifocal,| | |
Cholesterol | | 3 2.0|
Renal, Congestion | | 1 2.0|
Renal, Hyperplasia, Macrophage, | | |
Multifocal | | 1 2.0|
Renal, Pigmentation, Multifocal, | | |
Cholesterol | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Congestion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 7| 7| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Ectasia | | 16 1.6|
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrosis, Focal | | 8 2.6|
Fibrosis, Multifocal | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 24 |
Hyperplasia | | 2 2.0|
Duct, Cyst | | 7 1.4|
__________________________________________________________________________|____________|
Skin | | 47 |
Hyperkeratosis, Multifocal | | 1 4.0|
Hyperplasia, Focal | | 4 2.0|
Hyperplasia, Multifocal | | 1 4.0|
Inflammation, Multifocal, Subacute | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 22 |
Fibrous Osteodystrophy | | 8 2.0|
Cranium, Hypertrophy, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 22 |
Compression | | 2 2.0|
Hemorrhage, Multifocal | | 4 2.5|
Necrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.5|
__________________________________________________________________________|____________|
Nose | | 22 |
Foreign Body | | 7 2.0|
Fungus | | 9 2.7|
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 7| 7| 6| 6| 6| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Acute, Suppurative | | 10 2.2|
Nasolacrimal Duct, Foreign Body | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | | 22 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 15 |
Cataract | | 14 3.0|
Anterior Chamber, Hemorrhage | | 2 3.0|
Anterior Chamber, Inflammation, | | |
Acute, Suppurative | | 1 3.0|
Conjunctiva, Inflammation, Acute, | | |
Suppurative | | 1 3.0|
Cornea, Inflammation, Acute, | | |
Suppurative | | 1 2.0|
Cornea, Inflammation, Subacute | | 1 2.0|
Posterior Chamber, Hemorrhage | | 1 3.0|
Retina, Degeneration | | 14 3.1|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Nephropathy, Chronic | | 50 3.6|
Cortex, Cyst | | 6 2.2|
Cortex, Cyst, Multiple | | 7 1.9|
Papilla, Transitional Epithelium, | | |
Hyperplasia | | 43 1.1|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 4.0|
Renal Tubule, Hyperplasia | | 2 1.0|
Renal Tubule, Mineralization, | | |
Multifocal | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | | 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
__________________________________________________________________________|
Intestine Small | + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 1 2 1 |
Angiectasis, Multifocal | 2 2 2 2 2 2 3 1 2 2 2|
Basophilic Focus | X X X X X X X X X X X|
Basophilic Focus, Multiple | X X |
Clear Cell Focus | X X |
Degeneration, Cystic, Focal | 2 2 |
Degeneration, Cystic, Multifocal | 2 2 2 2 2 3 2 1 2 3 3 2 2 2 2|
Eosinophilic Focus | X X X X X X X X |
Eosinophilic Focus, Multiple | X X X 2 X X X X|
Granuloma, Multiple | 1 1 1 1 1 1 1 1 1 1 2 1 1 |
Hepatodiaphragmatic Nodule | 3 2 |
Inflammation, Subacute | 3 |
Mixed Cell Focus | X X X X X |
Mixed Cell Focus, Multiple | X X X X X|
Necrosis, Focal | |
Necrosis, Multifocal | 4 |
Pigmentation, Hemosiderin | 3 |
Vacuolization Cytoplasmic, Diffuse | 2 |
Biliary Tract, Proliferation | 3 2 2 2 3 2 4 3 2 2 2 3 2 2 2 2 2 2 2 3 2 2|
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Acinus, Atrophy, Multifocal | 1 1 1 2 3 4 1 2 2 2 2 1 2 2 2 4 1|
Acinus, Hyperplasia, Focal | |
Acinus, Hyperplasia, Multifocal | |
Artery, Inflammation, Subacute | |
Duct, Cyst | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Subacute | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
Cardiomyopathy | |
Atrium, Thrombosis | 3 X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 1 2 2 2 2 2 |
Degeneration, Fatty, Multifocal | 2 |
Hyperplasia, Focal | 2 2 2 2 3 2|
Capsule, Accessory Adrenal Cortical | |
Nodule | X 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 1 |
Hyperplasia, Multifocal | 2 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + |
Pars Distalis, Angiectasis | 3 2 3 3 3 |
Pars Distalis, Cyst | 2 3 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 2 1 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + |
C-Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + +|
Hyperplasia | 4|
Inflammation, Subacute | 2 2|
Duct, Cyst | 3 |
__________________________________________________________________________|
Prostate | + + + + |
Inflammation, Subacute | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + |
Dilatation | |
Inflammation, Subacute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 3 3 3 3 3 |
Interstitial Cell, Hyperplasia, Focal| 1 |
Interstitial Cell, Hyperplasia, | |
Multifocal | 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 |
Mediastinal, Ectasia | 2 |
Mesenteric, Ectasia | 3 2 |
Mesenteric, Giant Cell | 1 |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 1 1 2 1 1 1 1 1 2 1 2 2 3 1 1 1 1 1 1 2 1 2 2 1|
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 1 1 2 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 2 1 1 2 1|
Pancreatic, Amyloid Deposition | |
Pancreatic, Hyperplasia, Macrophage, | |
Multifocal | 2 |
Pancreatic, Pigmentation, Multifocal,| |
Cholesterol | 2 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 1 2 2 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 3 |
Necrosis, Focal | |
Capsule, Cyst | 2 |
__________________________________________________________________________|
Thymus | + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + |
Hyperplasia | 2 2 |
Duct, Cyst | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | 3 |
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + |
Hemorrhage, Multifocal | 3 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | 2 |
Necrosis | 2 |
Pigmentation, Hemosiderin, Multifocal| |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Bronchus, Fungus | 4 |
Bronchus, Inflammation, Acute, | |
Suppurative | 3 |
Pleura, Fibrosis, Focal | |
__________________________________________________________________________|
Nose | + + + + |
Foreign Body | |
Inflammation, Acute, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + M|
__________________________________________________________________________|
Eye | + + + + + + + + |
Cataract | 3 4 4 4 2 3 4 3 |
Anterior Chamber, Hemorrhage | 2 |
Cornea, Fibrosis | 2 |
Cornea, Inflammation, Subacute | |
Posterior Chamber, Hemorrhage | 1 2 |
Retina, Degeneration | 3 4 4 4 3 3 4 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 4 3 3 3 4 3 4 3 4|
Cortex, Cyst | 2 |
Cortex, Cyst, Multiple | 2 3|
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3|
| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|
| 6| 2| 2| 2| 2| 5| 4| 2| 2| 2| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 2 2 2 2 |
Angiectasis, Multifocal | 2 2 2 2 2 2 2 2 2|
Basophilic Focus | X X X |
Basophilic Focus, Multiple | |
Clear Cell Focus | X |
Degeneration, Cystic, Focal | 2 |
Degeneration, Cystic, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Eosinophilic Focus | X X X X X X X X |
Eosinophilic Focus, Multiple | X X X X X X X X X X X X X|
Granuloma, Multiple | 1 1 1 1 1 1 1 1 1 1 2 3 2 1 1 1 1 1|
Hepatodiaphragmatic Nodule | 3 2 3|
Inflammation, Subacute | |
Mixed Cell Focus | X X X X X X X X X |
Mixed Cell Focus, Multiple | X X X X X |
Necrosis, Focal | 1 |
Necrosis, Multifocal | |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic, Diffuse | |
Biliary Tract, Proliferation | 2 2 2 2 2 3 2 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2|
Centrilobular, Necrosis | 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis, Focal | 4 3 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Acinus, Atrophy, Multifocal | 1 1 2 2 1 3 1 2 2 2 2 3 1 2 1|
Acinus, Hyperplasia, Focal | 2 |
Acinus, Hyperplasia, Multifocal | 1 |
Artery, Inflammation, Subacute | 2 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|
| 6| 2| 2| 2| 2| 5| 4| 2| 2| 2| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Subacute | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Cardiomyopathy | 3 2 1 3 2 2 |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 2 1 2 1 2 2 |
Degeneration, Fatty, Multifocal | |
Hyperplasia, Focal | 2 1 1 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + |
Pars Distalis, Angiectasis | 2 2 4 2 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
C-Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Hyperplasia | 3 |
Inflammation, Subacute | 3 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Prostate | + + + + + + |
Inflammation, Subacute | 2 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|
| 6| 2| 2| 2| 2| 5| 4| 2| 2| 2| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + |
Dilatation | 2 |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 2 2 |
Interstitial Cell, Hyperplasia, Focal| 1 1 |
Interstitial Cell, Hyperplasia, | |
Multifocal | 2 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 2 2 |
Mediastinal, Ectasia | |
Mesenteric, Ectasia | 4 2 1 2 |
Mesenteric, Giant Cell | |
Mesenteric, Hyperplasia, Macrophage, | |
Multifocal | 1 3 2 1 2 1 2 1 2 1 1 2 2 2 2 3 3 1 2 1 2 1 1|
Mesenteric, Pigmentation, Multifocal,| |
Cholesterol | 1 2 2 1 1 1 1 1 1 1 1 1 2 1 2 2 2 1 1 1 2 1 1|
Pancreatic, Amyloid Deposition | 2 |
Pancreatic, Hyperplasia, Macrophage, | |
Multifocal | 2 2 |
Pancreatic, Pigmentation, Multifocal,| |
Cholesterol | 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 1 1 2 1 1 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 2|
Necrosis, Focal | 3 |
Capsule, Cyst | |
__________________________________________________________________________|
Thymus | + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
Hyperplasia | |
Duct, Cyst | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + |
Hyperkeratosis, Focal | 4 |
Hyperplasia, Focal | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|
| 6| 2| 2| 2| 2| 5| 4| 2| 2| 2| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
Fibrosis, Focal | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Hemorrhage, Multifocal | 2 1 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | |
Necrosis | 2 |
Pigmentation, Hemosiderin, Multifocal| 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 |
Bronchus, Fungus | |
Bronchus, Inflammation, Acute, | |
Suppurative | |
Pleura, Fibrosis, Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + |
Foreign Body | 2 |
Inflammation, Acute, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + + |
Cataract | 3 4 3 3 4 3 3 3 |
Anterior Chamber, Hemorrhage | 3 2 |
Cornea, Fibrosis | 3 |
Cornea, Inflammation, Subacute | 2 |
Posterior Chamber, Hemorrhage | 2 2 |
Retina, Degeneration | 3 4 3 4 4 4 3 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 4 3 4 4 2 4 4 4 2 2 2 4 3 4 4 4 4 3 3 2 4 3 3 3|
Cortex, Cyst | 3 |
Cortex, Cyst, Multiple | 2 3 |
Papilla, Transitional Epithelium, | |
Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
Page 112
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 0| 9| 3| 3| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3|
| 6| 2| 2| 2| 2| 5| 4| 2| 2| 2| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 113
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 7| 8| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 9 |
__________________________________________________________________________|____________|
Intestine Large | | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 10 |
__________________________________________________________________________|____________|
Intestine Small | | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 10 |
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis, Focal | | 10 1.8|
Angiectasis, Multifocal | | 20 2.0|
Basophilic Focus | | 14 |
Basophilic Focus, Multiple | | 2 |
Clear Cell Focus | | 3 |
Degeneration, Cystic, Focal | | 3 2.0|
Degeneration, Cystic, Multifocal | | 33 2.1|
Eosinophilic Focus | | 16 |
Eosinophilic Focus, Multiple | | 21 2.0|
Granuloma, Multiple | | 31 1.2|
Hepatodiaphragmatic Nodule | | 5 2.6|
Inflammation, Subacute | | 1 3.0|
Mixed Cell Focus | | 14 |
Mixed Cell Focus, Multiple | | 10 |
Necrosis, Focal | | 1 1.0|
Necrosis, Multifocal | | 1 4.0|
Pigmentation, Hemosiderin | | 1 3.0|
Vacuolization Cytoplasmic, Diffuse | | 1 2.0|
Biliary Tract, Proliferation | | 45 2.2|
Centrilobular, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Fat, Necrosis, Focal | | 4 3.3|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Basophilic Focus | | 2 |
Acinus, Atrophy, Multifocal | | 32 1.8|
Acinus, Hyperplasia, Focal | | 1 2.0|
Acinus, Hyperplasia, Multifocal | | 1 1.0|
Artery, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 7| 8| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Duct, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 10 |
__________________________________________________________________________|____________|
Stomach | | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 10 |
Hyperplasia | | 1 2.0|
Inflammation, Subacute | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 11 |
Cardiomyopathy | | 6 2.2|
Atrium, Thrombosis | | 3 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Degeneration, Fatty, Focal | | 12 1.8|
Degeneration, Fatty, Multifocal | | 1 2.0|
Hyperplasia, Focal | | 10 1.9|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia, Focal | | 4 1.8|
Hyperplasia, Multifocal | | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 12 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | | 16 |
Pars Distalis, Angiectasis | | 9 2.7|
Pars Distalis, Cyst | | 3 2.3|
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | | 3 1.7|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 11 |
C-Cell, Hyperplasia, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 7| 8| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 10 |
__________________________________________________________________________|____________|
Preputial Gland | | 13 |
Hyperplasia | | 2 3.5|
Inflammation, Subacute | | 3 2.3|
Duct, Cyst | | 2 3.0|
__________________________________________________________________________|____________|
Prostate | | 10 |
Inflammation, Subacute | | 7 1.9|
__________________________________________________________________________|____________|
Seminal Vesicle | | 11 |
Dilatation | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 49 |
Atrophy | | 12 2.6|
Interstitial Cell, Hyperplasia, Focal| | 3 1.0|
Interstitial Cell, Hyperplasia, | | |
Multifocal | | 7 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 10 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Congestion | | 3 2.0|
Mediastinal, Ectasia | | 1 2.0|
Mesenteric, Ectasia | | 6 2.3|
Mesenteric, Giant Cell | | 1 1.0|
Mesenteric, Hyperplasia, Macrophage, | | |
Multifocal | | 47 1.5|
Mesenteric, Pigmentation, Multifocal,| | |
Cholesterol | | 47 1.3|
Pancreatic, Amyloid Deposition | | 1 2.0|
Pancreatic, Hyperplasia, Macrophage, | | |
Multifocal | | 3 2.0|
Pancreatic, Pigmentation, Multifocal,| | |
Cholesterol | | 4 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Ectasia | | 17 1.4|
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrosis, Focal | | 4 2.5|
Necrosis, Focal | | 1 3.0|
Capsule, Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 7| 8| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 13 |
Hyperplasia | | 2 2.0|
Duct, Cyst | | 5 2.0|
__________________________________________________________________________|____________|
Skin | | 31 |
Hyperkeratosis, Focal | | 2 3.5|
Hyperplasia, Focal | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 10 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Fibrosis, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 11 |
Hemorrhage, Multifocal | | 3 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Inflammation, Acute, Suppurative | | 1 2.0|
Necrosis | | 2 2.0|
Pigmentation, Hemosiderin, Multifocal| | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 2.0|
Bronchus, Fungus | | 1 4.0|
Bronchus, Inflammation, Acute, | | |
Suppurative | | 1 3.0|
Pleura, Fibrosis, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 10 |
Foreign Body | | 1 2.0|
Inflammation, Acute, Suppurative | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 05019-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 3 Date: 04/29/97
Route: DOSED FEED Time: 06:45:21
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| | |
| 6| 6| 6| 6| 7| 8| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 16 |
Cataract | | 16 3.3|
Anterior Chamber, Hemorrhage | | 3 2.3|
Cornea, Fibrosis | | 2 2.5|
Cornea, Inflammation, Subacute | | 1 2.0|
Posterior Chamber, Hemorrhage | | 4 1.8|
Retina, Degeneration | | 16 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Nephropathy, Chronic | | 49 3.2|
Cortex, Cyst | | 2 2.5|
Cortex, Cyst, Multiple | | 4 2.5|
Papilla, Transitional Epithelium, | | |
Hyperplasia | | 40 1.0|
Renal Tubule, Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
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