TDMS Study 05019-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/03/94
EXP: 05019 CI PIGMENT RED 3 TIME: 14:50:25
TEST: 03 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 60366
CONT: NOIES9565102 CAS: 2425-85-6
PATHOLOGIST: H. GILES S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/03/94
EXP: 05019 CI PIGMENT RED 3 TIME: 14:50:25
TEST: 03 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 60366
CONT: NOIES9565102 CAS: 2425-85-6
PATHOLOGIST: H. GILES S. EUSTIS
CI PIGMENT RED 3
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 534 553 587 610 611 637 644 653 658 658 |
| 660 663 666 666 666 681 690 700 700 706 |
| 716 721 |
| CENSORED DEATHS |
| 456 456 456 456 456 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.6% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 9 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 398 420 581 605 610 616 624 651 660 694 |
| 696 |
| CENSORED DEATHS |
| 456 456 456 456 456 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.25% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 23 CENSORED DEATHS 9 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 452 529 540 575 576 576 578 598 610 641 |
| 682 682 687 690 695 707 708 708 710 710 |
| 714 718 722 |
| CENSORED DEATHS |
| 456 456 456 456 456 457 457 457 457 |
| |
==================================================================================
CI PIGMENT RED 3
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2.5% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 31 CENSORED DEATHS 9 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 451 486 567 577 581 605 612 612 624 626 |
| 643 655 658 658 666 678 679 680 681 682 |
| 690 690 694 708 710 710 716 718 718 723 |
| 723 |
| CENSORED DEATHS |
| 456 456 456 456 457 457 457 457 457 |
| |
==================================================================================
CI PIGMENT RED 3
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 94.0 76.0 56.0 |
|CONTROL | |
| | |
|0.6% | 100.0 100.0 100.0 100.0 96.7 96.7 96.7 92.7 82.9 78.9 |
| | |
| | |
|1.25% | 100.0 100.0 100.0 100.0 100.0 98.3 94.4 84.6 80.6 55.1 |
| | |
| | |
|2.5% | 100.0 100.0 100.0 100.0 100.0 98.3 96.4 88.5 72.8 39.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.6% 1.25% 2.5% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.0% 78.9% 55.1% 39.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.013 P=0.047N P=1.000 P=0.167 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 653.6 595.9 643.8 652.3 |
|NATURAL DEATHS (C) | (10.5) (29.9) (16.0) (12.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 656.0 663.7 655.5 648.5 |
|(STANDARD ERROR) | (13.0) (14.1) (13.4) (13.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CI PIGMENT RED 3
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 158 409 532 604 622 626 666 686 687 687 |
| 687 690 690 694 710 716 723 723 |
| CENSORED DEATHS |
| 458 458 458 458 458 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.6% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 10 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 390 457 508 518 587 612 639 665 694 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.25% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 429 491 567 597 611 653 658 680 682 694 |
| 708 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 459 459 459 459 |
| |
==================================================================================
CI PIGMENT RED 3
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2.5% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 427 477 519 553 574 611 682 687 711 723 |
| CENSORED DEATHS |
| 458 458 459 459 459 459 459 459 459 459 |
| |
==================================================================================
CI PIGMENT RED 3
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 98.3 98.3 98.3 96.7 96.7 94.7 92.6 88.6 64.4 |
|CONTROL | |
| | |
|0.6% | 100.0 100.0 100.0 100.0 98.3 96.7 92.6 90.6 84.6 82.6 |
| | |
| | |
|1.25% | 100.0 100.0 100.0 100.0 100.0 98.3 96.3 92.3 86.3 78.3 |
| | |
| | |
|2.5% | 100.0 100.0 100.0 100.0 100.0 96.3 94.3 90.3 88.3 80.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.6% 1.25% 2.5% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.4% 82.6% 78.3% 80.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.217N P=0.105N P=0.234N P=0.145N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 628.3 563.3 615.5 596.4 |
|NATURAL DEATHS (C) | (33.3) (33.9) (26.9) (32.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 653.7 659.0 663.1 661.9 |
|(STANDARD ERROR) | (16.1) (14.7) (14.0) (14.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CI PIGMENT RED 3
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.6% = 2
1.25% = 3
2.5% = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 2 2 3 4 3131 4 2
| 31 4 21 21
| 22
P 90 + 4 41 21
E | 3 344 2112
R | 3 3 4 121 2
C | 3 3 2 2
E 80 + 4 3 1 1 3 2 2
N | 4 4 33
T | 11
| 4 4 33
S 70 + 141 333
U | 411
R | 11
V | 11
I 60 + 44 131
V | 44 33
A | 4 413 1
L |
50 + 44
|
|
| 44
40 + 4 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 19 obs hidden.
CI PIGMENT RED 3
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.6% = 2
1.25% = 3
2.5% = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 43
| 1 2 1 43 2 4 3
|
| 1 2 4 3 2 41 3
95 + 22 1 1
| 4 4 3 3
| 2 4 4 2 3131
| 2 211
P 90 + 4 3 3
E | 2 1 2 1 4
R |
C | 2 3 21 14
E 85 + 2 112
N | 4 4
T | 3 2 4 4 2
|
S 80 + 3 3 4 4
U | 3 3
R |
V |
I 75 + 11
V |
A | 1 1
L |
70 + 11
| 11
|
|
65 + 1 1
|
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
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