TDMS Study 05021-04 Pathology Tables
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
Facility: Southern Research Institute
Chemical CAS #: 6471-49-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 7| 9| 5| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 3| 3| 4| 5| 3| 3| 3| 4| 4| 3| 4| 7| 4| 4| 4| 0| 4| 5| 5| 5| 5| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + M + + + + + + + +|
Wall, Mucocele | 1 1 |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 1 2 2 |
Submucosa, Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + A + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 1 |
__________________________________________________________________________|
Liver | + + + A + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 1 2 2 |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 3 2 |
Hepatocyte, Cytomegaly, Focal | 2 2 |
Hepatocyte, Necrosis | 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
__________________________________________________________________________|
Mesentery | +|
Inflammation, Acute | |
Inflammation, Chronic | |
Fat, Necrosis | 2|
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Acinar Cell, Atrophy | 4 4 |
Duct, Ectasia | 2 3 3 |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 |
Angiectasis | 2 |
Hyperkeratosis | 1 |
Ulcer | |
Epithelium, Hyperplasia | 1 1 |
Epithelium, Hyperplasia, Multiple | |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 7| 9| 5| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 3| 3| 4| 5| 3| 3| 3| 4| 4| 3| 4| 7| 4| 4| 4| 0| 4| 5| 5| 5| 5| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute | 1 |
Mineralization | 2 2 2 2|
Mucosa, Hyperplasia | 2 1 |
__________________________________________________________________________|
Tooth | + |
Incisor, Abscess | 2 |
Incisor, Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Pulmonary Artery, Inflammation, Acute| 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 1 2 1 |
Atrioventricular Valve, Thrombosis | |
Epicardium, Fibrosis | |
Interstitium, Fibrosis | 1 1 1 |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hypertrophy, Focal | 2 |
Inflammation, Acute | 2 |
Corticomedullary Junction, | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Extra Adrenal Tissue, Accessory | |
Adrenal Cortical Nodule | |
Spindle Cell, Hyperplasia | 3 3 2 3 3 3 3 2 2 2 2 3 2 2 2 2 3 2 3 3 3 3 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Ectopic Thymus | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Degeneration, Cystic | 1 |
Pars Distalis, Hyperplasia | 2 3 3 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 |
Follicle, Cyst | 2 1 |
Follicular Cell, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 7| 9| 5| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 3| 3| 4| 5| 3| 3| 3| 4| 4| 3| 4| 7| 4| 4| 4| 0| 4| 5| 5| 5| 5| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + A + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 4 4 |
Atrophy | 3 3 2 2 2 2 2 2 3 2 2 2 3 2 2 2|
Cyst | 1 |
Inflammation, Acute | |
Mineralization | 1 |
Pigmentation, Ceroid | 3 3 3 3 3 3 3 3 2 3 3 3 3 2 2 3 3 3 3 2|
Follicle, Cyst | 3 2 4 3 2 |
Follicle, Hemorrhage | |
Periovarian Tissue, Cyst | |
Periovarian Tissue, Inflammation, | |
Acute | 2 |
Periovarian Tissue, Inflammation, | |
Chronic | 3 3 |
__________________________________________________________________________|
Uterus | + + + A + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Exudate, Purulent | 2 3 2 2 |
Hemorrhage | 2 |
Hydrometra | 3 |
Endometrium, Hyperplasia, Cystic | 2 3 3 3 2 3 3 2 2 2 1 1 2 2 2 3 2 2 3 2 2 2|
Endometrium, Inflammation, Acute | 2 |
Endometrium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hypocellularity | 2 1 2|
Myelofibrosis | 1 2 2 1 1 1 1 1 1 1 2 |
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 2 4 2 3 1 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Iliac, Hyperplasia, Plasma Cell | |
Iliac, Inflammation, Chronic | 3 |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Inflammation, Acute | |
Mediastinal, Inflammation, Chronic | 3 2 |
Mesenteric, Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 7| 9| 5| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 3| 3| 4| 5| 3| 3| 3| 4| 4| 3| 4| 7| 4| 4| 4| 0| 4| 5| 5| 5| 5| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Autolysis | 4 |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
Mesenteric, Hyperplasia, Lymphoid | 1 3 2 1 |
Mesenteric, Hyperplasia, Plasma Cell | 3 |
Mesenteric, Inflammation, Acute | 2 |
Mesenteric, Inflammation, Chronic | 2 1 |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | |
Renal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 3 1 3 4 3 2 3 3 |
Hyperplasia, Lymphoid | 1 2 |
__________________________________________________________________________|
Thymus | + + M + A M M + + M M M + M M M M + M + M + M M M|
Atrophy | |
Cyst | 1 2 |
Cortex, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Skin | + + + A + + + + + + + + + + + + + + + + + + + + +|
Dermis, Fibrosis | 2 |
Dermis, Inflammation, Acute | |
Dermis, Inflammation, Chronic | 1 1 2 1 1 1 1 1 1 2 2 1 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Compression | 3 |
Meninges, Infiltration Cellular, | |
Lymphocyte | 3 |
Thalamus, Mineralization | 2 1 1 2 2 2 1 1 2 2 2 2 2 2 2 1 1 1 2 2|
Third Ventricle, Infiltration | |
Cellular, Lipocyte | 2 |
__________________________________________________________________________|
Spinal Cord | + |
Nerve, Demyelination | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 7| 9| 5| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 3| 3| 3| 4| 5| 3| 3| 3| 4| 4| 3| 4| 7| 4| 4| 4| 0| 4| 5| 5| 5| 5| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Acute | |
Pleura, Inflammation, Acute | 2 |
Pleura, Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Exudate, Purulent | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 1 1 2 1 2 |
Infarct, Chronic | 2 |
Nephropathy | 2 2 1 2 2 1 2 1 1 1|
Cortex, Metaplasia, Osseous | 1 |
Corticomedullary Junction, Embolus | |
Bacterial, Focal | |
Glomerulus, Inflammation, | |
Membranoproliferative | 3 4 3 |
Proximal Convoluted Renal Tubule, | |
Degeneration, Hyaline | |
Renal Tubule, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + M + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6|
DAY ON TEST | 8| 2| 2| 1| 5| 2| 1| 2| 2| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 1| 3|
| 5| 8| 8| 6| 9| 8| 8| 9| 9| 9| 9| 5| 9| 0| 0| 0| 0| 0| 0| 1| 1| 0| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + M + + + + + + + + + + + + + + + + + + +|
Wall, Mucocele | 1 |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + A + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
Submucosa, Edema | 2|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + A + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + A + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 3 1 3 2 2 4 |
Inflammation, Acute | 1 1 |
Inflammation, Chronic | |
Hepatocyte, Cytomegaly, Focal | |
Hepatocyte, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Acute | 3 3 |
Inflammation, Chronic | 3 3 |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 2 |
Acinar Cell, Atrophy | |
Duct, Ectasia | |
Perivascular, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 1 2 |
Angiectasis | |
Hyperkeratosis | 2 |
Ulcer | 1 1 |
Epithelium, Hyperplasia | 2 2 |
Epithelium, Hyperplasia, Multiple | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6|
DAY ON TEST | 8| 2| 2| 1| 5| 2| 1| 2| 2| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 1| 3|
| 5| 8| 8| 6| 9| 8| 8| 9| 9| 9| 9| 5| 9| 0| 0| 0| 0| 0| 0| 1| 1| 0| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute | |
Mineralization | 2 1 3 2 1 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
Incisor, Abscess | |
Incisor, Developmental Malformation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Pulmonary Artery, Inflammation, Acute| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 |
Atrioventricular Valve, Thrombosis | 2 |
Epicardium, Fibrosis | 2 |
Interstitium, Fibrosis | 1 |
Myocardium, Mineralization | 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Hypertrophy, Focal | |
Inflammation, Acute | |
Corticomedullary Junction, | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Extra Adrenal Tissue, Accessory | |
Adrenal Cortical Nodule | X |
Spindle Cell, Hyperplasia | 3 3 3 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Cyst | 3 2 |
Ectopic Thymus | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Degeneration, Cystic | 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Follicle, Cyst | 1 2 1 |
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6|
DAY ON TEST | 8| 2| 2| 1| 5| 2| 1| 2| 2| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 1| 3|
| 5| 8| 8| 6| 9| 8| 8| 9| 9| 9| 9| 5| 9| 0| 0| 0| 0| 0| 0| 1| 1| 0| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + I + + + + + + + + + + + + I + + + + +|
Abscess | 4 4 4 4 |
Atrophy | 2 3 2 2 2 2 2 2 |
Cyst | |
Inflammation, Acute | 1 |
Mineralization | |
Pigmentation, Ceroid | 2 3 2 2 2 2 3 3 3 2 2 2 2 2 2 |
Follicle, Cyst | 2 3 3 3 3 3 |
Follicle, Hemorrhage | 3 |
Periovarian Tissue, Cyst | 3 |
Periovarian Tissue, Inflammation, | |
Acute | 2 |
Periovarian Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Exudate, Purulent | 2 1 |
Hemorrhage | |
Hydrometra | 2 2 3 2 |
Endometrium, Hyperplasia, Cystic | 1 1 2 2 2 1 1 3 4 2 2 3 3 3 2 3 1 3 2 |
Endometrium, Inflammation, Acute | 2 |
Endometrium, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypocellularity | 1 |
Myelofibrosis | 1 1 1 2 2 1 1 1 2 2 |
Erythroid Cell, Hyperplasia | 2 |
Myeloid Cell, Hyperplasia | 3 3 2 3 2 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 |
Iliac, Hyperplasia, Plasma Cell | 3 |
Iliac, Inflammation, Chronic | |
Mediastinal, Hematopoietic Cell | |
Proliferation | 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Plasma Cell| 3 3 3 |
Mediastinal, Inflammation, Acute | 2 |
Mediastinal, Inflammation, Chronic | |
Mesenteric, Angiectasis | 1 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6|
DAY ON TEST | 8| 2| 2| 1| 5| 2| 1| 2| 2| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 1| 3|
| 5| 8| 8| 6| 9| 8| 8| 9| 9| 9| 9| 5| 9| 0| 0| 0| 0| 0| 0| 1| 1| 0| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Autolysis | |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 |
Mesenteric, Hyperplasia, Lymphoid | 1 1 1 4 1 2 3 |
Mesenteric, Hyperplasia, Plasma Cell | 2 |
Mesenteric, Inflammation, Acute | 2 2 |
Mesenteric, Inflammation, Chronic | |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Plasma Cell | 3 3 |
Renal, Inflammation, Acute | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 3 1 3 1 1 1 3 4 4 4|
Hyperplasia, Lymphoid | 1 2 1 2 |
__________________________________________________________________________|
Thymus | M M M M A + + + + + M M M + + M M M M M + M + M M|
Atrophy | 3 |
Cyst | 2 |
Cortex, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Fibrosis | |
Dermis, Inflammation, Acute | 2 2 |
Dermis, Inflammation, Chronic | 2 1 2 2 1 1 1 2 1 2 2 2 2|
Subcutaneous Tissue, Edema | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Compression | |
Meninges, Infiltration Cellular, | |
Lymphocyte | |
Thalamus, Mineralization | 2 1 2 2 1 1 1 2 2 2 1 2 2 1 2 2 1 2 1 2 1 2 2 2|
Third Ventricle, Infiltration | |
Cellular, Lipocyte | |
__________________________________________________________________________|
Spinal Cord | |
Nerve, Demyelination | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 6|
DAY ON TEST | 8| 2| 2| 1| 5| 2| 1| 2| 2| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 1| 3|
| 5| 8| 8| 6| 9| 8| 8| 9| 9| 9| 9| 5| 9| 0| 0| 0| 0| 0| 0| 1| 1| 0| 0| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | 3 2 |
Pleura, Inflammation, Acute | |
Pleura, Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Exudate, Purulent | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 |
Infarct, Chronic | 2 2 |
Nephropathy | 1 1 2 3 2 2 1 1 1 1 2 1 1 2|
Cortex, Metaplasia, Osseous | 1 |
Corticomedullary Junction, Embolus | |
Bacterial, Focal | 2 |
Glomerulus, Inflammation, | |
Membranoproliferative | 2 2 2 |
Proximal Convoluted Renal Tubule, | |
Degeneration, Hyaline | 3|
Renal Tubule, Dilatation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 6| 5| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 46 |
Wall, Mucocele | | 3 1.0|
__________________________________________________________________________|____________|
Intestine Large | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 47 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 3 1.7|
Submucosa, Edema | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 46 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 46 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 2 1.5|
__________________________________________________________________________|____________|
Liver | | 49 |
Fibrosis, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | | 9 2.2|
Inflammation, Acute | | 2 1.0|
Inflammation, Chronic | | 4 2.3|
Hepatocyte, Cytomegaly, Focal | | 2 2.0|
Hepatocyte, Necrosis | | 2 1.5|
Hepatocyte, Vacuolization Cytoplasmic| | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Inflammation, Acute | | 2 3.0|
Inflammation, Chronic | | 2 3.0|
Fat, Necrosis | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Inflammation, Acute | | 3 1.7|
Acinar Cell, Atrophy | | 2 4.0|
Duct, Ectasia | | 3 2.7|
Perivascular, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Abscess | | 4 1.3|
Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 6| 5| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | | 2 1.5|
Ulcer | | 2 1.0|
Epithelium, Hyperplasia | | 4 1.5|
Epithelium, Hyperplasia, Multiple | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
Inflammation, Acute | | 1 1.0|
Mineralization | | 9 1.9|
Mucosa, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Tooth | | 2 |
Incisor, Abscess | | 1 2.0|
Incisor, Developmental Malformation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Pulmonary Artery, Inflammation, Acute| | 1 2.0|
__________________________________________________________________________|____________|
Heart | | 50 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 4 1.3|
Atrioventricular Valve, Thrombosis | | 1 2.0|
Epicardium, Fibrosis | | 1 2.0|
Interstitium, Fibrosis | | 4 1.0|
Myocardium, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 49 |
Hematopoietic Cell Proliferation | | 2 2.5|
Hypertrophy, Focal | | 1 2.0|
Inflammation, Acute | | 1 2.0|
Corticomedullary Junction, | | |
Pigmentation | | 46 1.0|
Extra Adrenal Tissue, Accessory | | |
Adrenal Cortical Nodule | | 1 |
Spindle Cell, Hyperplasia | | 49 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 49 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
Cyst | | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 6| 5| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Ectopic Thymus | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Degeneration, Cystic | | 2 1.5|
Pars Distalis, Hyperplasia | | 10 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Inflammation, Acute | | 2 1.0|
Follicle, Cyst | | 5 1.4|
Follicular Cell, Hyperplasia | | 6 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 47 |
Abscess | | 8 4.0|
Atrophy | | 24 2.2|
Cyst | | 1 1.0|
Inflammation, Acute | | 1 1.0|
Mineralization | | 1 1.0|
Pigmentation, Ceroid | | 35 2.6|
Follicle, Cyst | | 11 2.8|
Follicle, Hemorrhage | | 1 3.0|
Periovarian Tissue, Cyst | | 1 3.0|
Periovarian Tissue, Inflammation, | | |
Acute | | 2 2.0|
Periovarian Tissue, Inflammation, | | |
Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Uterus | | 49 |
Abscess | | 1 2.0|
Exudate, Purulent | | 6 2.0|
Hemorrhage | | 1 2.0|
Hydrometra | | 5 2.4|
Endometrium, Hyperplasia, Cystic | | 41 2.2|
Endometrium, Inflammation, Acute | | 2 2.0|
Endometrium, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 6| 5| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Hypocellularity | | 4 1.5|
Myelofibrosis | | 21 1.3|
Erythroid Cell, Hyperplasia | | 1 2.0|
Myeloid Cell, Hyperplasia | | 13 2.7|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
Iliac, Hyperplasia, Plasma Cell | | 1 3.0|
Iliac, Inflammation, Chronic | | 1 3.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 3 3.0|
Mediastinal, Inflammation, Acute | | 1 2.0|
Mediastinal, Inflammation, Chronic | | 2 2.5|
Mesenteric, Angiectasis | | 1 1.0|
Mesenteric, Autolysis | | 1 4.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid | | 11 1.8|
Mesenteric, Hyperplasia, Plasma Cell | | 2 2.5|
Mesenteric, Inflammation, Acute | | 3 2.0|
Mesenteric, Inflammation, Chronic | | 2 1.5|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Plasma Cell | | 2 3.0|
Renal, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 4 2.5|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 23 2.6|
Hyperplasia, Lymphoid | | 6 1.5|
__________________________________________________________________________|____________|
Thymus | | 18 |
Atrophy | | 1 3.0|
Cyst | | 3 1.7|
Cortex, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 6| 5| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
Inflammation, Chronic | | 2 2.0|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 49 |
Dermis, Fibrosis | | 1 2.0|
Dermis, Inflammation, Acute | | 2 2.0|
Dermis, Inflammation, Chronic | | 25 1.4|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Cerebellum, Compression | | 1 3.0|
Meninges, Infiltration Cellular, | | |
Lymphocyte | | 1 3.0|
Thalamus, Mineralization | | 44 1.6|
Third Ventricle, Infiltration | | |
Cellular, Lipocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Nerve, Demyelination | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Acute | | 2 2.5|
Pleura, Inflammation, Acute | | 1 2.0|
Pleura, Inflammation, Chronic | | 4 1.8|
__________________________________________________________________________|____________|
Nose | | 50 |
Nasolacrimal Duct, Exudate, Purulent | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Phthisis Bulbi | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 6| 5| 6| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Casts Protein | | 7 1.6|
Infarct, Chronic | | 3 2.0|
Nephropathy | | 24 1.5|
Cortex, Metaplasia, Osseous | | 2 1.0|
Corticomedullary Junction, Embolus | | |
Bacterial, Focal | | 1 2.0|
Glomerulus, Inflammation, | | |
Membranoproliferative | | 6 2.7|
Proximal Convoluted Renal Tubule, | | |
Degeneration, Hyaline | | 1 3.0|
Renal Tubule, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 47 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 2| 2| 8| 9| 2| 2| 2| 2| 5| 5| 2|
| 3| 3| 3| 8| 3| 4| 3| 7| 4| 4| 7| 4| 3| 4| 5| 5| 8| 9| 5| 5| 5| 8| 2| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + A A + + + + + A +|
Epithelium, Cytoplasmic Alteration | 2 |
Wall, Mucocele | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + A A + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A A + + + + + A +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
Lymphoid Tissue, Pigmentation | 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A A + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A A + + + + + A +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A A + + + + + A +|
Submucosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A A + + + + + A +|
Lymphoid Tissue, Pigmentation | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A A + + + + + + +|
Lymphoid Tissue, Hyperplasia, Plasma | |
Cell | |
Lymphoid Tissue, Hyperplasia, Re Cell| |
Lymphoid Tissue, Pigmentation | 2 2 2 2 1 1 1 2 2 2 1 2 1 2 2 1 2|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +|
Clear Cell Focus | 2 |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Acute | 1 2 |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A A + + + + + + +|
Cytoplasmic Alteration | 1 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 1 1 2 1 2 2 1 2 1 3 2 1|
Hyperkeratosis | 1 3 2 2 3 3 2 1 1 1 1 |
Inflammation, Chronic | 2 |
Ulcer | 1 1 2 2 1 2 1 1 2 2 2 1 1 2 1 3 1 1|
Epithelium, Cyst | |
Epithelium, Hyperplasia | 2 3 2 1 2 2 2 |
Epithelium, Hyperplasia, Multiple | 2 3 2 2 2 2 2 3 2 2 1 2 2 2 2 2|
Submucosa, Edema | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 2| 2| 8| 9| 2| 2| 2| 2| 5| 5| 2|
| 3| 3| 3| 8| 3| 4| 3| 7| 4| 4| 7| 4| 3| 4| 5| 5| 8| 9| 5| 5| 5| 8| 2| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 2 1 1 2 2 1 2|
Ulcer | 3 |
Submucosa, Edema | |
__________________________________________________________________________|
Tongue | + |
Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Polyarteritis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Interstitium, Fibrosis | 1 1 1 |
Myocardium, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia, Focal | |
Hypertrophy, Focal | 1 |
Corticomedullary Junction, | |
Pigmentation | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A A + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Ectopic Thymus | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Degeneration, Cystic | 2 |
Pars Distalis, Hyperplasia | 2 2 1 1 1 1 1 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Ultimobranchial Cyst | |
Follicle, Cyst | 2 1 2 2 1 |
Follicular Cell, Hyperplasia | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + I + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 2| 2| 8| 9| 2| 2| 2| 2| 5| 5| 2|
| 3| 3| 3| 8| 3| 4| 3| 7| 4| 4| 7| 4| 3| 4| 5| 5| 8| 9| 5| 5| 5| 8| 2| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Abscess | 4 |
Atrophy | 2 3 2 2 2 2 2 2 2 2|
Hyperplasia, Tubular | |
Pigmentation, Ceroid | 3 3 3 2 2 3 1 3 3 1 3 3 3 3 1 2 3 3 2 2 3|
Follicle, Cyst | 3 3 2 1 |
Follicle, Hemorrhage | |
Periovarian Tissue, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Purulent | 3 1 2 |
Hemorrhage | |
Hydrometra | |
Endometrium, Hyperplasia, Cystic | 3 2 2 2 2 2 2 2 2 1 2 1 2 2 1 2 2 2 2 2 2 4|
Endometrium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 1 2 2 1 1 1 1 2 1 2 1 3|
Myeloid Cell, Hyperplasia | 3 2 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Plasma Cell | |
Mediastinal, Edema | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Autolysis | 4 4 |
Mesenteric, Hyperplasia, Lymphoid | 1 1 1 |
Mesenteric, Inflammation, Acute | |
Mesenteric, Pigmentation | 1 1 2 1 2 2 2 2 2 1 2 2 2 2 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Plasma Cell | |
Renal, Lymphocyte, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Granulomatous | |
Arteriole, Amyloid Deposition | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 4 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | 2 1 3 1 1 |
Red Pulp, Depletion Cellular | 3 |
__________________________________________________________________________|
Thymus | + M + M + + M + + + + M + M + + + M + + + + + M +|
Atrophy | 4 |
Cyst | 1 1 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 2| 2| 8| 9| 2| 2| 2| 2| 5| 5| 2|
| 3| 3| 3| 8| 3| 4| 3| 7| 4| 4| 7| 4| 3| 4| 5| 5| 8| 9| 5| 5| 5| 8| 2| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Acinus, Hyperplasia | |
Duct, Dilatation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | 1 1 1 2 1 2 2 2 1 |
Epidermis, Pigmentation | 2 |
Subcutaneous Tissue, Abscess | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Compression | |
Cerebrum, Degeneration | 2 |
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 |
Thalamus, Mineralization | 1 1 2 1 1 1 2 1 2 1 2 2 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Pleura, Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Purulent | 3 |
Foreign Body | 3 |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
Vomeronasal Organ, Inflammation, | |
Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 1 2 |
Infarct, Chronic | 2 |
Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 |
Cortex, Metaplasia, Osseous | 2 2 2 1 |
Glomerulus, Amyloid Deposition | |
Glomerulus, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 9| 2| 8| 2| 2| 2| 8| 9| 2| 2| 2| 2| 5| 5| 2|
| 3| 3| 3| 8| 3| 4| 3| 7| 4| 4| 7| 4| 3| 4| 5| 5| 8| 9| 5| 5| 5| 8| 2| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Membranoproliferative | 2 |
Proximal Convoluted Renal Tubule, | |
Degeneration, Hyaline | |
Renal Tubule, Dilatation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A A + + + + + A +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 0| 5| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 1| 2| 2| 2| 2| 2| 5| 8| 3| 2| 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 3| 5| 8| 8| 8| 9| 9| 8| 5| 3| 9| 9| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Cytoplasmic Alteration | |
Wall, Mucocele | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 1 1|
Lymphoid Tissue, Pigmentation | 1 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Pigmentation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, Plasma | |
Cell | 3|
Lymphoid Tissue, Hyperplasia, Re Cell| 3|
Lymphoid Tissue, Pigmentation | 2 2 2 1 1 1 2 1 1 2 1 2 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Hematopoietic Cell Proliferation | 3 2|
Inflammation, Acute | |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Kupffer Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 2 2 2 1 1 1 1 1 2 2 2 2 1 3 2 1 2 2 |
Hyperkeratosis | 2 2 1 1 1 1 2|
Inflammation, Chronic | 2 1 |
Ulcer | 1 1 2 2 2 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1|
Epithelium, Cyst | 2 |
Epithelium, Hyperplasia | 1 1 1 2 3 2 2 2 2 2 1 2 1|
Epithelium, Hyperplasia, Multiple | 1 1 3 3 3 1 3 2 3 3 3 |
Submucosa, Edema | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 0| 5| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 1| 2| 2| 2| 2| 2| 5| 8| 3| 2| 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 3| 5| 8| 8| 8| 9| 9| 8| 5| 3| 9| 9| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 2 2 1 |
Ulcer | |
Submucosa, Edema | 2 |
__________________________________________________________________________|
Tongue | |
Angiectasis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Polyarteritis | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Interstitium, Fibrosis | |
Myocardium, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2 |
Corticomedullary Junction, | |
Pigmentation | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 1 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 |
Ectopic Thymus | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M +|
Pars Distalis, Angiectasis | 1 3 |
Pars Distalis, Degeneration, Cystic | 1 1 |
Pars Distalis, Hyperplasia | 2 3 3 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Ultimobranchial Cyst | 2 1 |
Follicle, Cyst | 1 2|
Follicular Cell, Hyperplasia | 1 1 1 1 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 0| 5| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 1| 2| 2| 2| 2| 2| 5| 8| 3| 2| 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 3| 5| 8| 8| 8| 9| 9| 8| 5| 3| 9| 9| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Abscess | 4 |
Atrophy | 2 2 2 2 2 3 2 1 2 2 2 2 2 2 2 2 2 2|
Hyperplasia, Tubular | 2 |
Pigmentation, Ceroid | 3 3 3 3 3 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 3 3|
Follicle, Cyst | 2 1 2 2 2 3 2 2 3 |
Follicle, Hemorrhage | 2 |
Periovarian Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Purulent | 2 |
Hemorrhage | 2 |
Hydrometra | 3 |
Endometrium, Hyperplasia, Cystic | 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 3 2 |
Endometrium, Inflammation, Acute | 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 1 1 1 1 1 1 2 1 2 2 |
Myeloid Cell, Hyperplasia | 1 3 4|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Plasma Cell | 3 4|
Mediastinal, Edema | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mesenteric, Autolysis | |
Mesenteric, Hyperplasia, Lymphoid | 1 1 2 2 1 1|
Mesenteric, Inflammation, Acute | 1 |
Mesenteric, Pigmentation | 1 1 2 2 1 1 1 2 2 1 1 2 2 1 2 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | 3 3|
Renal, Lymphocyte, Necrosis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Granulomatous | 3 |
Arteriole, Amyloid Deposition | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 1 2 2 3 3 2 2 2 4|
Hyperplasia, Lymphoid | 2 1 1 1 |
Red Pulp, Depletion Cellular | |
__________________________________________________________________________|
Thymus | + + + + + M + + M + M + + + + + + + + + + + + +|
Atrophy | 4 2 3|
Cyst | 1 1 |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 0| 5| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 1| 2| 2| 2| 2| 2| 5| 8| 3| 2| 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 3| 5| 8| 8| 8| 9| 9| 8| 5| 3| 9| 9| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia | 2 3 1 |
Duct, Dilatation | 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | 2 2 2 2 2 2 1 2 2 2 2 2 |
Epidermis, Pigmentation | |
Subcutaneous Tissue, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Compression | 2 2 |
Cerebrum, Degeneration | |
Meninges, Infiltration Cellular, | |
Lymphocyte | |
Thalamus, Mineralization | 1 1 1 1 2 2 1 1 2 1 1 1 2 1 1 1 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Pleura, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Purulent | |
Foreign Body | |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Vomeronasal Organ, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 1 1 3 |
Infarct, Chronic | |
Nephropathy | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 |
Cortex, Metaplasia, Osseous | 2 1 |
Glomerulus, Amyloid Deposition | 4 |
Glomerulus, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 0| 5| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 1| 2| 2| 2| 2| 2| 5| 8| 3| 2| 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 3| 5| 8| 8| 8| 9| 9| 8| 5| 3| 9| 9| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Membranoproliferative | 2 1|
Proximal Convoluted Renal Tubule, | |
Degeneration, Hyaline | 3 2 |
Renal Tubule, Dilatation | 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 48 |
__________________________________________________________________________|____________|
Gallbladder | | 46 |
Epithelium, Cytoplasmic Alteration | | 1 2.0|
Wall, Mucocele | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | | 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 46 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 2 1.0|
Lymphoid Tissue, Pigmentation | | 5 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 46 |
__________________________________________________________________________|____________|
Intestine Small | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 46 |
Submucosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 46 |
Lymphoid Tissue, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 47 |
Lymphoid Tissue, Hyperplasia, Plasma | | |
Cell | | 1 3.0|
Lymphoid Tissue, Hyperplasia, Re Cell| | 1 3.0|
Lymphoid Tissue, Pigmentation | | 31 1.6|
__________________________________________________________________________|____________|
Liver | | 48 |
Clear Cell Focus | | 1 2.0|
Hematopoietic Cell Proliferation | | 3 2.3|
Inflammation, Acute | | 2 1.5|
Hepatocyte, Vacuolization Cytoplasmic| | 1 3.0|
Kupffer Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | | 47 |
Cytoplasmic Alteration | | 1 1.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Abscess | | 32 1.6|
Hyperkeratosis | | 18 1.7|
Inflammation, Chronic | | 3 1.7|
Ulcer | | 38 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Cyst | | 1 2.0|
Epithelium, Hyperplasia | | 20 1.8|
Epithelium, Hyperplasia, Multiple | | 27 2.2|
Submucosa, Edema | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 45 |
Mineralization | | 10 1.6|
Ulcer | | 1 3.0|
Submucosa, Edema | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Angiectasis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Polyarteritis | | 1 3.0|
__________________________________________________________________________|____________|
Heart | | 49 |
Inflammation, Chronic | | 2 1.0|
Interstitium, Fibrosis | | 3 1.0|
Myocardium, Degeneration | | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 48 |
Hyperplasia, Focal | | 1 2.0|
Hypertrophy, Focal | | 2 1.5|
Corticomedullary Junction, | | |
Pigmentation | | 45 1.0|
Spindle Cell, Hyperplasia | | 47 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 47 |
Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
Cyst | | 3 1.7|
Ectopic Thymus | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Pars Distalis, Angiectasis | | 2 2.0|
Pars Distalis, Degeneration, Cystic | | 3 1.3|
Pars Distalis, Hyperplasia | | 11 1.7|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 1.0|
Ultimobranchial Cyst | | 2 1.5|
Follicle, Cyst | | 7 1.6|
Follicular Cell, Hyperplasia | | 11 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 48 |
Abscess | | 2 4.0|
Atrophy | | 28 2.0|
Hyperplasia, Tubular | | 1 2.0|
Pigmentation, Ceroid | | 43 2.4|
Follicle, Cyst | | 13 2.2|
Follicle, Hemorrhage | | 1 2.0|
Periovarian Tissue, Inflammation, | | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | | 49 |
Exudate, Purulent | | 4 2.0|
Hemorrhage | | 1 2.0|
Hydrometra | | 1 3.0|
Endometrium, Hyperplasia, Cystic | | 43 2.1|
Endometrium, Inflammation, Acute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Myelofibrosis | | 26 1.4|
Myeloid Cell, Hyperplasia | | 7 2.7|
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Iliac, Hyperplasia, Plasma Cell | | 2 3.5|
Mediastinal, Edema | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mesenteric, Autolysis | | 2 4.0|
Mesenteric, Hyperplasia, Lymphoid | | 9 1.2|
Mesenteric, Inflammation, Acute | | 1 1.0|
Mesenteric, Pigmentation | | 29 1.6|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Plasma Cell | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Lymphocyte, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Inflammation, Acute | | 1 1.0|
Inflammation, Granulomatous | | 1 3.0|
Arteriole, Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 48 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | | 17 2.4|
Hyperplasia, Lymphoid | | 9 1.4|
Red Pulp, Depletion Cellular | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 39 |
Atrophy | | 4 3.3|
Cyst | | 4 1.0|
Hyperplasia, Lymphoid | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 48 |
Acinus, Hyperplasia | | 3 2.0|
Duct, Dilatation | | 3 1.7|
__________________________________________________________________________|____________|
Skin | | 49 |
Dermis, Inflammation, Chronic | | 21 1.7|
Epidermis, Pigmentation | | 1 2.0|
Subcutaneous Tissue, Abscess | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
Cerebrum, Compression | | 2 2.0|
Cerebrum, Degeneration | | 1 2.0|
Meninges, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Thalamus, Mineralization | | 35 1.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 49 |
Inflammation, Acute | | 1 1.0|
Pleura, Inflammation, Chronic | | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | | 49 |
Exudate, Purulent | | 1 3.0|
Foreign Body | | 1 3.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 1 3.0|
Vomeronasal Organ, Inflammation, | | |
Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Casts Protein | | 6 1.7|
Infarct, Chronic | | 1 2.0|
Nephropathy | | 26 1.1|
Cortex, Metaplasia, Osseous | | 6 1.7|
Glomerulus, Amyloid Deposition | | 1 4.0|
Glomerulus, Inflammation, | | |
Membranoproliferative | | 3 1.7|
Proximal Convoluted Renal Tubule, | | |
Degeneration, Hyaline | | 2 2.5|
Renal Tubule, Dilatation | | 3 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 0| 2| 8| 2| 4| 2| 2| 2| 2| 2| 2|
| 2| 3| 3| 3| 3| 1| 3| 4| 4| 4| 1| 4| 4| 5| 7| 1| 5| 5| 5| 5| 5| 5| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + A + M + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
Lymphoid Tissue, Pigmentation | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + M + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Lymphoid Tissue, Pigmentation | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Lymphoid Tissue, Pigmentation | 2 2 1 1 1 1 2 2 2 1 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Inflammation, Acute | 2 |
Mitotic Alteration | 3 |
Hepatocyte, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + |
Inflammation, Chronic | |
Acinar Cell, Atrophy | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 2 1 1 1 1 1 2 2 2 2 1 2 1 |
Hyperkeratosis | 3 |
Inflammation, Chronic | 2 |
Ulcer | 2 1 1 1 2 2 2 1 1 2 1 1 1 1 1 |
Epithelium, Hyperplasia | 2 2 1 2 1 2 2 2 2 1 1|
Epithelium, Hyperplasia, Multiple | 2 2 2 2 2 2 3 1 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 0| 2| 8| 2| 4| 2| 2| 2| 2| 2| 2|
| 2| 3| 3| 3| 3| 1| 3| 4| 4| 4| 1| 4| 4| 5| 7| 1| 5| 5| 5| 5| 5| 5| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Hypertrophy, Diffuse | 3 |
Corticomedullary Junction, | |
Pigmentation | 1 |
Extra Adrenal Tissue, Accessory | |
Adrenal Cortical Nodule | 2 |
Spindle Cell, Hyperplasia | 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + |
Abscess | 4 |
Atrophy | 2 2 2 3 3 2 |
Cyst | 2 2 |
Pigmentation, Ceroid | 2 2 2 2 2 2 2 1 2 2 |
Follicle, Cyst | 2 3 3 |
Follicle, Hemorrhage | 4 |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4 2 |
Endometrium, Cyst | 1 1 |
Endometrium, Hyperplasia, Cystic | 3 2 2 2 2 2 2 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 1 1 1 2 1 1 1 1 2 1 1 1 1|
Myeloid Cell, Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Abscess | |
Mesenteric, Angiectasis | 2 |
Mesenteric, Hematopoietic Cell | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 0| 2| 8| 2| 4| 2| 2| 2| 2| 2| 2|
| 2| 3| 3| 3| 3| 1| 3| 4| 4| 4| 1| 4| 4| 5| 7| 1| 5| 5| 5| 5| 5| 5| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation | 2|
Mesenteric, Hyperplasia, Lymphoid | 2 3 2 2 |
Mesenteric, Inflammation, Acute | |
Mesenteric, Inflammation, Chronic | 3 |
Mesenteric, Pigmentation | 2 2 2 2 1 2 2 1 1 |
Pancreatic, Hyperplasia, Lymphoid | 4 |
Pancreatic, Inflammation, | |
Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 3 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + M + M + I + |
Atrophy | 2 2 |
Cyst | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
Acinus, Hyperplasia | |
Duct, Dilatation | |
Duct, Ectasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + |
Dermis, Inflammation, Chronic | 2 1 2 2 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Cerebrum, Compression | 1 |
Thalamus, Mineralization | 1 2 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | |
Artery, Foreign Body | |
Artery, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 0| 2| 8| 2| 4| 2| 2| 2| 2| 2| 2|
| 2| 3| 3| 3| 3| 1| 3| 4| 4| 4| 1| 4| 4| 5| 7| 1| 5| 5| 5| 5| 5| 5| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + +|
Phthisis Bulbi | 3 3|
__________________________________________________________________________|
Harderian Gland | + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
Nephropathy | 1 |
Glomerulus, Inflammation, | |
Membranoproliferative | |
Proximal Convoluted Renal Tubule, | |
Renal Tubule, Degeneration, | |
Hyaline | 3 |
Proximal Convoluted Renal Tubule, | |
Renal Tubule, Pigmentation | |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 0| 2| 2| 7| 2| 2| 2| 6| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 5| 8| 6| 8| 9| 2| 9| 9| 9| 7| 6| 1| 9| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 2 3 |
Lymphoid Tissue, Pigmentation | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoid Tissue, Pigmentation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoid Tissue, Pigmentation | 1 1 2 1 1 1 2 1 1 1 2 2 1 1|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 2 2 1 1 3|
Inflammation, Acute | 2 |
Mitotic Alteration | |
Hepatocyte, Necrosis | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + +|
Inflammation, Chronic | 2|
Acinar Cell, Atrophy | 2|
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 1 2 2 2 1 2 1 1 1 2 1 2 2 |
Hyperkeratosis | 1 1 |
Inflammation, Chronic | 1 |
Ulcer | 2 2 2 2 2 2 1 1 2 1 1 2 1 2 1 |
Epithelium, Hyperplasia | 1 2 1 1 2 2 2 2 2 1 1 1 2 2 1 2 |
Epithelium, Hyperplasia, Multiple | 2 3 2 3 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + +|
Inflammation, Chronic | 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 0| 2| 2| 7| 2| 2| 2| 6| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 5| 8| 6| 8| 9| 2| 9| 9| 9| 7| 6| 1| 9| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + +|
Hypertrophy, Diffuse | |
Corticomedullary Junction, | |
Pigmentation | 1 2 |
Extra Adrenal Tissue, Accessory | |
Adrenal Cortical Nodule | |
Spindle Cell, Hyperplasia | 2 2 2 2 3 4 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + +|
Ultimobranchial Cyst | 2 |
Follicular Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + +|
Abscess | 4|
Atrophy | |
Cyst | |
Pigmentation, Ceroid | 2 1 2 2 |
Follicle, Cyst | 2 3 2 2 3 2 2 |
Follicle, Hemorrhage | |
Periovarian Tissue, Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Endometrium, Cyst | 2 |
Endometrium, Hyperplasia, Cystic | 2 2 1 1 3 3 3 2 2 1 3 2 2 3 2 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 1 1 1 1 1 1 1 1 2 1 1 |
Myeloid Cell, Hyperplasia | 2 2 4|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Abscess | 3|
Mesenteric, Angiectasis | 1 |
Mesenteric, Hematopoietic Cell | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 0| 2| 2| 7| 2| 2| 2| 6| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 5| 8| 6| 8| 9| 2| 9| 9| 9| 7| 6| 1| 9| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Proliferation | |
Mesenteric, Hyperplasia, Lymphoid | 2 1 2 1 |
Mesenteric, Inflammation, Acute | 1 |
Mesenteric, Inflammation, Chronic | |
Mesenteric, Pigmentation | 2 1 1 1 1 1 1 2 2 2 2 2 1 2 2 1 1 |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Inflammation, | |
Granulomatous | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 3 3 2 3 3 2 4|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + M + + + +|
Atrophy | |
Cyst | 1 1|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + +|
Acinus, Hyperplasia | 2 |
Duct, Dilatation | 3 |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | 1 2 2 2 2 2 2 1 1 2 2 1 1 4 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + +|
Cerebrum, Compression | |
Thalamus, Mineralization | 1 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Foreign Body | 2 |
Artery, Mineralization | 1 |
__________________________________________________________________________|
Nose | + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 0| 2| 2| 7| 2| 2| 2| 6| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
| 5| 8| 6| 8| 9| 2| 9| 9| 9| 7| 6| 1| 9| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + +|
Nephropathy | |
Glomerulus, Inflammation, | |
Membranoproliferative | 3|
Proximal Convoluted Renal Tubule, | |
Renal Tubule, Degeneration, | |
Hyaline | |
Proximal Convoluted Renal Tubule, | |
Renal Tubule, Pigmentation | 2 |
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + A + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 5| 5| 6| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 14 |
__________________________________________________________________________|____________|
Gallbladder | | 12 |
__________________________________________________________________________|____________|
Intestine Large | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 3 2.3|
Lymphoid Tissue, Pigmentation | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
__________________________________________________________________________|____________|
Intestine Small | | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 47 |
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 48 |
Lymphoid Tissue, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 48 |
Lymphoid Tissue, Pigmentation | | 25 1.4|
__________________________________________________________________________|____________|
Liver | | 50 |
Hematopoietic Cell Proliferation | | 7 1.6|
Inflammation, Acute | | 2 2.0|
Mitotic Alteration | | 1 3.0|
Hepatocyte, Necrosis | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | | 15 |
Inflammation, Chronic | | 1 2.0|
Acinar Cell, Atrophy | | 1 2.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | | 14 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Abscess | | 28 1.5|
Hyperkeratosis | | 3 1.7|
Inflammation, Chronic | | 2 1.5|
Ulcer | | 30 1.5|
Epithelium, Hyperplasia | | 27 1.6|
Epithelium, Hyperplasia, Multiple | | 16 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Mineralization | | 6 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 5| 5| 6| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 14 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 14 |
Hypertrophy, Diffuse | | 1 3.0|
Corticomedullary Junction, | | |
Pigmentation | | 3 1.3|
Extra Adrenal Tissue, Accessory | | |
Adrenal Cortical Nodule | | 1 2.0|
Spindle Cell, Hyperplasia | | 14 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 14 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 14 |
__________________________________________________________________________|____________|
Pituitary Gland | | 16 |
Pars Distalis, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 14 |
Ultimobranchial Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 28 |
Abscess | | 2 4.0|
Atrophy | | 6 2.3|
Cyst | | 2 2.0|
Pigmentation, Ceroid | | 14 1.9|
Follicle, Cyst | | 10 2.4|
Follicle, Hemorrhage | | 1 4.0|
Periovarian Tissue, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | | 39 |
Hydrometra | | 3 3.0|
Endometrium, Cyst | | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 5| 5| 6| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic | | 29 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Myelofibrosis | | 27 1.2|
Myeloid Cell, Hyperplasia | | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mesenteric, Abscess | | 1 3.0|
Mesenteric, Angiectasis | | 2 1.5|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Mesenteric, Hyperplasia, Lymphoid | | 8 1.9|
Mesenteric, Inflammation, Acute | | 1 1.0|
Mesenteric, Inflammation, Chronic | | 1 3.0|
Mesenteric, Pigmentation | | 26 1.5|
Pancreatic, Hyperplasia, Lymphoid | | 1 4.0|
Pancreatic, Inflammation, | | |
Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 15 |
__________________________________________________________________________|____________|
Spleen | | 25 |
Hematopoietic Cell Proliferation | | 15 2.5|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | | 14 |
Atrophy | | 2 2.0|
Cyst | | 2 1.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 15 |
Acinus, Hyperplasia | | 1 2.0|
Duct, Dilatation | | 1 3.0|
Duct, Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Skin | | 48 |
Dermis, Inflammation, Chronic | | 28 1.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 14 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 0| 5| 5| 6| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | | 14 |
Cerebrum, Compression | | 1 1.0|
Thalamus, Mineralization | | 8 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 49 |
Congestion | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Artery, Foreign Body | | 1 2.0|
Artery, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 14 |
__________________________________________________________________________|____________|
Trachea | | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Phthisis Bulbi | | 2 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 15 |
Nephropathy | | 1 1.0|
Glomerulus, Inflammation, | | |
Membranoproliferative | | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Renal Tubule, Degeneration, | | |
Hyaline | | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Renal Tubule, Pigmentation | | 1 2.0|
Renal Tubule, Mineralization | | 1 2.0|
Renal Tubule, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 0| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 6| 2| 1| 2| 2| 0| 2| 2| 2| 8|
| 7| 0| 3| 3| 3| 3| 3| 4| 4| 2| 5| 4| 4| 4| 5| 9| 5| 0| 5| 5| 3| 5| 8| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
Inflammation, Chronic | 3 2|
__________________________________________________________________________|
Gallbladder | + A + + + A + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Polyarteritis | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
Lymphoid Tissue, Pigmentation | 1 2 2 1 2 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 1 |
Polyarteritis | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Inflammation, Acute | 2 |
Polyarteritis | 3 |
Acinar Cell, Atrophy | 1|
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 1 1 |
Hyperkeratosis | 2 |
Ulcer | 2 1 |
Epithelium, Hyperplasia | 1 2 3 |
Epithelium, Hyperplasia, Multiple | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Mineralization | 1 |
Mucosa, Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 0| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 6| 2| 1| 2| 2| 0| 2| 2| 2| 8|
| 7| 0| 3| 3| 3| 3| 3| 4| 4| 2| 5| 4| 4| 4| 5| 9| 5| 0| 5| 5| 3| 5| 8| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
Inflammation, Chronic | 3 |
Myocardium, Inflammation, Acute | |
Myocardium, Inflammation | |
Myocardium, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
Congestion | 2 |
Inflammation, Acute | 2 |
Spindle Cell, Hyperplasia | 1 2 2 3 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Hyperplasia | 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + +|
Ultimobranchial Cyst | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + +|
Abscess | 4 |
Atrophy | 2 3 3 |
Pigmentation, Ceroid | 2 3 1 2 3|
Polyarteritis | 2 |
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Exudate, Purulent | |
Hemorrhage | |
Hydrometra | |
Polyarteritis | 2 |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 3 3 2 2 2 3 2 2 2 2 3 1 1 |
Endometrium, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 0| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 6| 2| 1| 2| 2| 0| 2| 2| 2| 8|
| 7| 0| 3| 3| 3| 3| 3| 4| 4| 2| 5| 4| 4| 4| 5| 9| 5| 0| 5| 5| 3| 5| 8| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypocellularity | 2 |
Myelofibrosis | 1 2 1 1 1 2 1 1 |
Myeloid Cell, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Edema | |
Iliac, Hyperplasia, Plasma Cell | |
Mediastinal, Abscess | 3 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Inflammation, Acute | |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 3 1 |
Mesenteric, Hyperplasia, Plasma Cell | |
Mesenteric, Pigmentation | 1 |
Mesenteric, Lymphocyte, Necrosis | 2 |
Renal, Abscess | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 |
__________________________________________________________________________|
Thymus | + M + M + M + M|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Acute | 2 |
Dermis, Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
Thalamus, Mineralization | 2 1 1 2 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 0| 0| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 6| 2| 1| 2| 2| 0| 2| 2| 2| 8|
| 7| 0| 3| 3| 3| 3| 3| 4| 4| 2| 5| 4| 4| 4| 5| 9| 5| 0| 5| 5| 3| 5| 8| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Mineralization | 1 |
Artery, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + +|
Sinus, Exudate, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + +|
Infarct, Chronic | 2 |
Nephropathy | 3 |
Glomerulus, Inflammation, | |
Membranoproliferative | |
Proximal Convoluted Renal Tubule, | |
Renal Tubule, Degeneration, | |
Hyaline | 2 |
Renal Tubule, Hypertrophy | 2 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
Polyarteritis | 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 8| 2| 2| 3| 7| 3| 3| 3| 1| 3| 2| 4| 3| 3| 3| 1| 3| 3| 6| 3|
| 9| 9| 9| 3| 9| 7| 9| 9| 0| 1| 0| 0| 0| 9| 0| 0| 7| 0| 0| 0| 6| 0| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + A + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Gallbladder | + + + + A + + A |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + A +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + A +|
Inflammation, Chronic | |
Polyarteritis | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + + + + A + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + A + + A +|
Polyarteritis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + A + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + A + + A +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 1 |
Lymphoid Tissue, Pigmentation | 1 1 1 1 1 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 2 |
Inflammation, Acute | |
Inflammation, Chronic | |
Polyarteritis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 |
__________________________________________________________________________|
Pancreas | + + + + A + + M |
Inflammation, Acute | |
Polyarteritis | |
Acinar Cell, Atrophy | 4 1 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
Inflammation, Acute | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + + + +|
Abscess | 2 1|
Hyperkeratosis | |
Ulcer | 1 2 1 1|
Epithelium, Hyperplasia | 1 1 2 1 1 2 |
Epithelium, Hyperplasia, Multiple | 2 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + A +|
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Mineralization | 2 2 1|
Mucosa, Cyst | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 8| 2| 2| 3| 7| 3| 3| 3| 1| 3| 2| 4| 3| 3| 3| 1| 3| 3| 6| 3|
| 9| 9| 9| 3| 9| 7| 9| 9| 0| 1| 0| 0| 0| 9| 0| 0| 7| 0| 0| 0| 6| 0| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Inflammation, Chronic | |
Myocardium, Inflammation, Acute | 1 |
Myocardium, Inflammation | 2 |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + A + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + A + + + |
Congestion | |
Inflammation, Acute | |
Spindle Cell, Hyperplasia | 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + A + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + M |
__________________________________________________________________________|
Parathyroid Gland | M M + + M M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + A + + + + |
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + M + + + + |
Abscess | 4 4 4 |
Atrophy | 2 2 3 |
Pigmentation, Ceroid | 2 1 2 3 |
Polyarteritis | |
Follicle, Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + A + + + + + + |
Abscess | 4 |
Exudate, Purulent | 3 |
Hemorrhage | 2 |
Hydrometra | 2 |
Polyarteritis | |
Endometrium, Cyst | 1 |
Endometrium, Hyperplasia, Cystic | 3 2 2 2 2 3 4 2 3 2 2 1 3 3 3 |
Endometrium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 8| 2| 2| 3| 7| 3| 3| 3| 1| 3| 2| 4| 3| 3| 3| 1| 3| 3| 6| 3|
| 9| 9| 9| 3| 9| 7| 9| 9| 0| 1| 0| 0| 0| 9| 0| 0| 7| 0| 0| 0| 6| 0| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hypocellularity | 1 |
Myelofibrosis | 2 1 1 1 1 1 |
Myeloid Cell, Hyperplasia | 3 3 2 2|
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + + A + + + + + + + + +|
Iliac, Edema | 3 |
Iliac, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Abscess | |
Mediastinal, Hyperplasia, Plasma Cell| 4 |
Mediastinal, Inflammation, Acute | 2 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 3 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 |
Mesenteric, Hyperplasia, Plasma Cell | 2 |
Mesenteric, Pigmentation | 1 1 1 |
Mesenteric, Lymphocyte, Necrosis | |
Renal, Abscess | 2 |
Renal, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + A + + + + |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + |
Hematopoietic Cell Proliferation | 3 4 3 3 |
__________________________________________________________________________|
Thymus | M + M + M M M + M M |
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Acute | |
Dermis, Inflammation, Chronic | 2 2 2 2 2 1 2 1 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + A + + + |
Thalamus, Mineralization | 2 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 8| 2| 2| 3| 7| 3| 3| 3| 1| 3| 2| 4| 3| 3| 3| 1| 3| 3| 6| 3|
| 9| 9| 9| 3| 9| 7| 9| 9| 0| 1| 0| 0| 0| 9| 0| 0| 7| 0| 0| 0| 6| 0| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Mineralization | |
Artery, Mineralization | 2 |
__________________________________________________________________________|
Nose | + + + + A + + + |
Sinus, Exudate, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + A + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + M + + + |
Infarct, Chronic | |
Nephropathy | 1 |
Glomerulus, Inflammation, | |
Membranoproliferative | 2 |
Proximal Convoluted Renal Tubule, | |
Renal Tubule, Degeneration, | |
Hyaline | 3 |
Renal Tubule, Hypertrophy | |
Renal Tubule, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + |
Polyarteritis | 1 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 15 |
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Gallbladder | | 12 |
__________________________________________________________________________|____________|
Intestine Large | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 47 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 5 2.2|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 48 |
Inflammation, Chronic | | 1 2.0|
Polyarteritis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 46 |
Polyarteritis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 46 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 1.0|
Lymphoid Tissue, Pigmentation | | 12 1.3|
__________________________________________________________________________|____________|
Liver | | 49 |
Hematopoietic Cell Proliferation | | 4 2.3|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 2 1.0|
Polyarteritis | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| | 3 1.7|
__________________________________________________________________________|____________|
Pancreas | | 14 |
Inflammation, Acute | | 1 2.0|
Polyarteritis | | 1 3.0|
Acinar Cell, Atrophy | | 3 2.0|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | | 16 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
Abscess | | 5 1.2|
Hyperkeratosis | | 1 2.0|
Ulcer | | 6 1.3|
Epithelium, Hyperplasia | | 9 1.6|
Epithelium, Hyperplasia, Multiple | | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | | 4 1.5|
Mucosa, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 16 |
Inflammation, Chronic | | 1 3.0|
Myocardium, Inflammation, Acute | | 1 1.0|
Myocardium, Inflammation | | 1 2.0|
Myocardium, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 15 |
Congestion | | 1 2.0|
Inflammation, Acute | | 1 2.0|
Spindle Cell, Hyperplasia | | 14 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 15 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | | 23 |
Pars Distalis, Angiectasis | | 2 4.0|
Pars Distalis, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 15 |
Ultimobranchial Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 20 |
Abscess | | 4 4.0|
Atrophy | | 6 2.5|
Pigmentation, Ceroid | | 9 2.1|
Polyarteritis | | 1 2.0|
Follicle, Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | | 41 |
Abscess | | 1 4.0|
Exudate, Purulent | | 1 3.0|
Hemorrhage | | 1 2.0|
Hydrometra | | 1 2.0|
Polyarteritis | | 1 2.0|
Endometrium, Cyst | | 1 1.0|
Endometrium, Hyperplasia, Cystic | | 28 2.3|
Endometrium, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Hypocellularity | | 2 1.5|
Myelofibrosis | | 14 1.2|
Myeloid Cell, Hyperplasia | | 7 2.4|
__________________________________________________________________________|____________|
Lymph Node | | 48 |
Iliac, Edema | | 1 3.0|
Iliac, Hyperplasia, Plasma Cell | | 1 3.0|
Mediastinal, Abscess | | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 4.0|
Mediastinal, Inflammation, Acute | | 1 2.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 2 3.0|
Mesenteric, Hyperplasia, Lymphoid | | 14 2.0|
Mesenteric, Hyperplasia, Plasma Cell | | 1 2.0|
Mesenteric, Pigmentation | | 4 1.0|
Mesenteric, Lymphocyte, Necrosis | | 1 2.0|
Renal, Abscess | | 1 2.0|
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 18 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 21 |
Hematopoietic Cell Proliferation | | 7 3.1|
__________________________________________________________________________|____________|
Thymus | | 7 |
Atrophy | | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 15 |
__________________________________________________________________________|____________|
Skin | | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Dermis, Inflammation, Acute | | 1 2.0|
Dermis, Inflammation, Chronic | | 25 1.9|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 16 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 15 |
Thalamus, Mineralization | | 12 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Acute | | 2 1.5|
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolus, Mineralization | | 1 1.0|
Artery, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 15 |
Sinus, Exudate, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 17 |
Infarct, Chronic | | 1 2.0|
Nephropathy | | 2 2.0|
Glomerulus, Inflammation, | | |
Membranoproliferative | | 1 2.0|
Proximal Convoluted Renal Tubule, | | |
Renal Tubule, Degeneration, | | |
Hyaline | | 2 2.5|
Renal Tubule, Hypertrophy | | 1 2.0|
Renal Tubule, Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 6| 5| 5| 5| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | | 15 |
Polyarteritis | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 1| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 0| 5| 7| 6| 7|
DAY ON TEST | 4| 2| 5| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 8| 4| 2| 4| 2| 2| 2| 2| 1| 2| 1| 2|
| 0| 3| 5| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 7| 4| 4| 4| 4| 4| 4| 7| 8| 5| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + A + + + + + + + + + M + + + + A + + A|
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Intestine Large | A + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + A + + + A + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + A + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + A + + + A + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + A + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + A + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + A + + + A + + + + + + + + + + + + + A A + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + A + + + A + + + + + + + + + + + + + A A + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 |
Lymphoid Tissue, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Liver | + + + + + + A + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatocyte, Necrosis | 2 2 |
Sinusoid, Dilatation | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +|
Acinar Cell, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + A + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, | |
Hyperplasia | 2 |
__________________________________________________________________________|
Stomach | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 |
Ulcer, Focal | |
Mucosa, Hyperplasia | 2 2 |
__________________________________________________________________________|
Tooth | + + + |
Incisor, Developmental Malformation | 3 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
Artery, Polyarteritis, Chronic | 2 |
Interstitium, Fibrosis | 1 2 |
Myocardium, Degeneration | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 1| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 0| 5| 7| 6| 7|
DAY ON TEST | 4| 2| 5| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 8| 4| 2| 4| 2| 2| 2| 2| 1| 2| 1| 2|
| 0| 3| 5| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 7| 4| 4| 4| 4| 4| 4| 7| 8| 5| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + A + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + A + + + + + + + + + + + + + M + + + +|
Clear Cell Focus | 2 2 |
Cyst | |
Hyperplasia, Focal | 1 |
Hypertrophy, Focal | 1 1 |
Extra Adrenal Tissue, Accessory | |
Adrenal Cortical Nodule | X |
Spindle Cell, Hyperplasia | 1 2 2 2 1 3 2 2 2 2 1 2 1 2 2 2 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + A + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + M +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + A + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ultimobranchial Cyst | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + A + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hypospermia | 4 |
Inflammation, Chronic | |
Spermatocele | |
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + M |
Abscess | |
Inflammation, Chronic | 4 3 |
Duct, Ectasia | 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + A + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 1| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 0| 5| 7| 6| 7|
DAY ON TEST | 4| 2| 5| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 8| 4| 2| 4| 2| 2| 2| 2| 1| 2| 1| 2|
| 0| 3| 5| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 7| 4| 4| 4| 4| 4| 4| 7| 8| 5| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + A + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Testes | + + + + + + A + + + + + + + + + + + + + + + + + +|
Polyarteritis, Chronic | 1 |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 1 1 |
Seminiferous Tubule, Degeneration | |
Seminiferous Tubule, Giant Cell | 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 2 4 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + A + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 4 |
Inguinal, Hyperplasia, Lymphoid | 2 3 |
Inguinal, Hyperplasia, Plasma Cell | 3 |
Mesenteric, Angiectasis | 1 1 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 2 1 2 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 1 2 1 2 2 2 2 1 |
Mesenteric, Inflammation, Acute | |
Mesenteric, Thrombosis | |
Mesenteric, Lymphocyte, Necrosis | 2 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
Hyperplasia, Re Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 4 2 2 2 2|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Re Cell | |
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + M + + + M M M + M +|
Atrophy | 3|
Cyst | 2 |
Inflammation, Acute | |
Cortex, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + A + + + + + + + + + + + + + + + + + +|
Parakeratosis | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 1| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 0| 5| 7| 6| 7|
DAY ON TEST | 4| 2| 5| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 8| 4| 2| 4| 2| 2| 2| 2| 1| 2| 1| 2|
| 0| 3| 5| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 7| 4| 4| 4| 4| 4| 4| 7| 8| 5| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Ulcer | 3 |
Dermis, Fibrosis | |
Dermis, Inflammation, Acute | |
Dermis, Inflammation, Chronic | 2 3 1 2 1 2 3 |
Epithelium, Hyperplasia | |
Prepuce, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + A + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage | |
Inflammation, Acute | 1 |
Alveolar Epithelium, Hyperplasia | |
Peribronchial, Glands, Exudate | 2 |
Perivascular, Inflammation, Chronic | 3 |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + A + + + + + + + + + + + + + + + + + +|
Exudate, Purulent | 2 2 2 |
Foreign Body | 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 3 |
Lumen, Hemorrhage | |
Nasolacrimal Duct, Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Submucosa, Cyst | 2 |
Vomeronasal Organ, Exudate, Purulent | 2 |
Vomeronasal Organ, Foreign Body | 2 |
__________________________________________________________________________|
Trachea | + + + + + + A + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 1| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 0| 5| 7| 6| 7|
DAY ON TEST | 4| 2| 5| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 8| 4| 2| 4| 2| 2| 2| 2| 1| 2| 1| 2|
| 0| 3| 5| 3| 3| 3| 4| 3| 3| 3| 3| 4| 3| 7| 4| 4| 4| 4| 4| 4| 7| 8| 5| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | 2 |
Infarct, Chronic | 3 |
Inflammation, Acute | |
Nephropathy | 1 1 1 2 1 1 1 2 1 3 2 3 1 2 1 2 1 1|
Artery, Polyarteritis, Chronic | 2 |
Cortex, Renal Tubule, Necrosis, Acute| |
Medulla, Congestion | |
Pelvis, Inflammation, Acute | |
Proximal Convoluted Renal Tubule, | |
Degeneration, Hyaline | |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Hypertrophy | |
Renal Tubule, Mineralization | 1 2 1 1 1 1 2 |
__________________________________________________________________________|
Urethra | + |
Inflammation, Acute | 3 |
Bulbourethral Gland, Ectasia | |
Bulbourethral Gland, Inflammation, | |
Acute | |
__________________________________________________________________________|
Urinary Bladder | + + A + + + A + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 4| 6| 5| 6| 7|
DAY ON TEST | 6| 2| 2| 2| 1| 2| 2| 2| 2| 4| 2| 2| 2| 0| 2| 4| 2| 1| 4| 2| 1| 1| 3| 4| 2|
| 3| 5| 5| 5| 1| 8| 5| 8| 8| 4| 8| 9| 9| 4| 9| 4| 9| 1| 7| 9| 8| 0| 6| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + A + + A + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + A + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | M + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + A + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + A + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + A + + A + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + A + + A + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 |
Lymphoid Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Hematopoietic Cell Proliferation | 3 2 |
Hepatocyte, Necrosis | 3 |
Sinusoid, Dilatation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, | |
Hyperplasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 1 2 1 1|
Ulcer, Focal | 1 |
Mucosa, Hyperplasia | 2 2 |
__________________________________________________________________________|
Tooth | |
Incisor, Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Artery, Polyarteritis, Chronic | |
Interstitium, Fibrosis | 2 2 1 2 2|
Myocardium, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 4| 6| 5| 6| 7|
DAY ON TEST | 6| 2| 2| 2| 1| 2| 2| 2| 2| 4| 2| 2| 2| 0| 2| 4| 2| 1| 4| 2| 1| 1| 3| 4| 2|
| 3| 5| 5| 5| 1| 8| 5| 8| 8| 4| 8| 9| 9| 4| 9| 4| 9| 1| 7| 9| 8| 0| 6| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 |
Cyst | 2 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 1 2 2 1 1 1 |
Extra Adrenal Tissue, Accessory | |
Adrenal Cortical Nodule | |
Spindle Cell, Hyperplasia | 2 2 2 2 2 1 1 2 2 2 2 1 2 2 1 1 2 2 2 3 1 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + I + + + + + + + + + + + + + + + + M|
Cyst | 2 3 |
__________________________________________________________________________|
Pituitary Gland | M + M + + + + M + + + + M + M + + + + + M + M M +|
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Ultimobranchial Cyst | 2 |
Follicle, Cyst | 2 2 1 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hypospermia | 2 |
Inflammation, Chronic | 2 |
Spermatocele | 4 |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Abscess | 4 |
Inflammation, Chronic | 2 4 2 4 |
Duct, Ectasia | 3 4 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 4| 6| 5| 6| 7|
DAY ON TEST | 6| 2| 2| 2| 1| 2| 2| 2| 2| 4| 2| 2| 2| 0| 2| 4| 2| 1| 4| 2| 1| 1| 3| 4| 2|
| 3| 5| 5| 5| 1| 8| 5| 8| 8| 4| 8| 9| 9| 4| 9| 4| 9| 1| 7| 9| 8| 0| 6| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis, Chronic | |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 1 1 |
Seminiferous Tubule, Degeneration | 2 |
Seminiferous Tubule, Giant Cell | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 4 2 2 3 3 3 3 1 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | 4 |
Inguinal, Hyperplasia, Plasma Cell | |
Mesenteric, Angiectasis | 2 2 2 2 1 2 1 3 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 2 3 2 3 3 2 1 2 2|
Mesenteric, Hyperplasia, Lymphoid | 2 3 2 2 2 2 |
Mesenteric, Inflammation, Acute | 1 2 1 1 |
Mesenteric, Thrombosis | 3 |
Mesenteric, Lymphocyte, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 3 3 3 3 2 4 1 1 3 2 2 |
Hyperplasia, Lymphoid | 2 2 2 1 |
Hyperplasia, Re Cell | 2 |
Lymphocyte, Necrosis | 2 2 |
__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + + + + M M + M + + +|
Atrophy | 3 2 2 2 4 2 |
Cyst | 1 2 2 1 2 2 1 2 1 1 1|
Inflammation, Acute | 2 |
Cortex, Necrosis | 2 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parakeratosis | 2 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 4| 6| 5| 6| 7|
DAY ON TEST | 6| 2| 2| 2| 1| 2| 2| 2| 2| 4| 2| 2| 2| 0| 2| 4| 2| 1| 4| 2| 1| 1| 3| 4| 2|
| 3| 5| 5| 5| 1| 8| 5| 8| 8| 4| 8| 9| 9| 4| 9| 4| 9| 1| 7| 9| 8| 0| 6| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Ulcer | 3 3 3 |
Dermis, Fibrosis | 2 |
Dermis, Inflammation, Acute | 4 |
Dermis, Inflammation, Chronic | 2 3 1 2 1 2 1 2 1 2 2 1 |
Epithelium, Hyperplasia | 3 3 2 |
Prepuce, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 2 2 1 2 1 1 1 2 3 1 1 1 1 1 1 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 3 |
Inflammation, Acute | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Peribronchial, Glands, Exudate | |
Perivascular, Inflammation, Chronic | |
Pleura, Fibrosis | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Purulent | |
Foreign Body | |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | |
Lumen, Hemorrhage | 2 |
Nasolacrimal Duct, Foreign Body | 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Submucosa, Cyst | |
Vomeronasal Organ, Exudate, Purulent | |
Vomeronasal Organ, Foreign Body | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5| 6| 7| 4| 6| 5| 6| 7|
DAY ON TEST | 6| 2| 2| 2| 1| 2| 2| 2| 2| 4| 2| 2| 2| 0| 2| 4| 2| 1| 4| 2| 1| 1| 3| 4| 2|
| 3| 5| 5| 5| 1| 8| 5| 8| 8| 4| 8| 9| 9| 4| 9| 4| 9| 1| 7| 9| 8| 0| 6| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | 1 |
Infarct, Chronic | |
Inflammation, Acute | 4 |
Nephropathy | 3 1 1 2 1 2 1 1 1 2 2 1 1 1 2 1 1 3 2 |
Artery, Polyarteritis, Chronic | |
Cortex, Renal Tubule, Necrosis, Acute| 2 |
Medulla, Congestion | 2 |
Pelvis, Inflammation, Acute | 4 |
Proximal Convoluted Renal Tubule, | |
Degeneration, Hyaline | 3 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Hypertrophy | 2 |
Renal Tubule, Mineralization | 1 2 3 1 |
__________________________________________________________________________|
Urethra | + + + |
Inflammation, Acute | 3 2 |
Bulbourethral Gland, Ectasia | 3 |
Bulbourethral Gland, Inflammation, | |
Acute | 3 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + A + + A + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 4| 3| 4| 4| 3| 3| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 48 |
__________________________________________________________________________|____________|
Gallbladder | | 40 |
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 44 |
__________________________________________________________________________|____________|
Intestine Small | | 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 42 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 42 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 2 3.0|
Lymphoid Tissue, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Liver | | 49 |
Basophilic Focus | | 2 2.0|
Hematopoietic Cell Proliferation | | 3 2.0|
Hepatocyte, Necrosis | | 3 2.3|
Sinusoid, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Acinar Cell, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
Duct, Submandibular Gland, | | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
Mineralization | | 9 1.3|
Ulcer, Focal | | 1 1.0|
Mucosa, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Tooth | | 3 |
Incisor, Developmental Malformation | | 3 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Heart | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 4| 3| 4| 4| 3| 3| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 2 1.5|
Artery, Polyarteritis, Chronic | | 1 2.0|
Interstitium, Fibrosis | | 7 1.7|
Myocardium, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 48 |
Clear Cell Focus | | 3 2.0|
Cyst | | 1 2.0|
Hyperplasia, Focal | | 1 1.0|
Hypertrophy, Focal | | 8 1.3|
Extra Adrenal Tissue, Accessory | | |
Adrenal Cortical Nodule | | 1 |
Spindle Cell, Hyperplasia | | 41 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 48 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 46 |
Cyst | | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | | 41 |
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Inflammation, Chronic | | 1 2.0|
Ultimobranchial Cyst | | 1 2.0|
Follicle, Cyst | | 4 1.8|
Follicular Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 49 |
Fibrosis | | 1 3.0|
Hypospermia | | 2 3.0|
Inflammation, Chronic | | 1 2.0|
Spermatocele | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 4| 3| 4| 4| 3| 3| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | | 9 |
Abscess | | 1 4.0|
Inflammation, Chronic | | 6 3.2|
Duct, Ectasia | | 6 3.2|
__________________________________________________________________________|____________|
Prostate | | 48 |
Hemorrhage | | 1 3.0|
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 49 |
Depletion Cellular | | 1 2.0|
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Testes | | 49 |
Polyarteritis, Chronic | | 1 1.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
Seminiferous Tubule, Atrophy | | 4 1.0|
Seminiferous Tubule, Degeneration | | 1 2.0|
Seminiferous Tubule, Giant Cell | | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 49 |
Myeloid Cell, Hyperplasia | | 13 2.7|
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Inguinal, Hyperplasia, Lymphoid | | 3 3.0|
Inguinal, Hyperplasia, Plasma Cell | | 1 3.0|
Mesenteric, Angiectasis | | 10 1.7|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 14 2.1|
Mesenteric, Hyperplasia, Lymphoid | | 16 1.9|
Mesenteric, Inflammation, Acute | | 4 1.3|
Mesenteric, Thrombosis | | 1 3.0|
Mesenteric, Lymphocyte, Necrosis | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Hyperplasia, Plasma Cell | | 1 3.0|
Hyperplasia, Re Cell | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 4| 3| 4| 4| 3| 3| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | | 49 |
Hematopoietic Cell Proliferation | | 20 2.5|
Hyperplasia, Lymphoid | | 5 1.8|
Hyperplasia, Re Cell | | 1 2.0|
Lymphocyte, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | | 39 |
Atrophy | | 7 2.6|
Cyst | | 12 1.5|
Inflammation, Acute | | 1 2.0|
Cortex, Necrosis | | 4 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | | 49 |
Parakeratosis | | 1 2.0|
Ulcer | | 4 3.0|
Dermis, Fibrosis | | 1 2.0|
Dermis, Inflammation, Acute | | 1 4.0|
Dermis, Inflammation, Chronic | | 20 1.9|
Epithelium, Hyperplasia | | 3 2.7|
Prepuce, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Thalamus, Mineralization | | 39 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 49 |
Congestion | | 2 2.5|
Hemorrhage | | 2 2.5|
Inflammation, Acute | | 2 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Peribronchial, Glands, Exudate | | 1 2.0|
Perivascular, Inflammation, Chronic | | 1 3.0|
Pleura, Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 1| 4| 3| 4| 4| 3| 3| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Exudate, Purulent | | 3 2.0|
Foreign Body | | 1 2.0|
Inflammation, Acute | | 2 1.5|
Inflammation, Chronic Active | | 1 3.0|
Lumen, Hemorrhage | | 1 2.0|
Nasolacrimal Duct, Foreign Body | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Submucosa, Cyst | | 1 2.0|
Vomeronasal Organ, Exudate, Purulent | | 1 2.0|
Vomeronasal Organ, Foreign Body | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Phthisis Bulbi | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Cyst | | 2 1.5|
Infarct, Chronic | | 1 3.0|
Inflammation, Acute | | 1 4.0|
Nephropathy | | 37 1.5|
Artery, Polyarteritis, Chronic | | 1 2.0|
Cortex, Renal Tubule, Necrosis, Acute| | 1 2.0|
Medulla, Congestion | | 1 2.0|
Pelvis, Inflammation, Acute | | 1 4.0|
Proximal Convoluted Renal Tubule, | | |
Degeneration, Hyaline | | 1 3.0|
Renal Tubule, Dilatation | | 2 2.0|
Renal Tubule, Hypertrophy | | 1 2.0|
Renal Tubule, Mineralization | | 11 1.5|
__________________________________________________________________________|____________|
Urethra | | 4 |
Inflammation, Acute | | 3 2.7|
Bulbourethral Gland, Ectasia | | 1 3.0|
Bulbourethral Gland, Inflammation, | | |
Acute | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 44 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 1| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 7| 2| 5| 2| 5| 2| 2| 0| 2| 2| 0| 2| 7| 4| 7| 2| 2| 2| 4| 2| 2| 6| 2| 2| 2|
| 1| 3| 1| 3| 9| 3| 4| 0| 3| 4| 3| 4| 2| 8| 3| 5| 4| 4| 7| 5| 5| 9| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + A + M + + + + + + + + + + + + + + + + A + + +|
Epithelium, Cytoplasmic Alteration | 3 |
Wall, Mucocele | 2|
__________________________________________________________________________|
Intestine Large | + + A + A + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A + + + + + + + + + + + + + + + + A + + +|
Lymphoid Tissue, Pigmentation | |
__________________________________________________________________________|
Intestine Large, Colon | + + A + A + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + A + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small | + + A + A + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + A + + + + + + + + + + + + + + + + A + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + A + + + + + + + + + + + + + + + + A + + +|
Lymphoid Tissue, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + A + + + + + + + + + + + + + + + + A + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 4 3 |
Lymphoid Tissue, Pigmentation | 2 2 1 2 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + A + + +|
Basophilic Focus | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Hepatocyte, Necrosis | 1 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + A + + +|
Acinar Cell, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + + + A + + +|
Duct, Ectasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperkeratosis | 1 2 |
Inflammation, Acute | 2 1 1 |
Epithelium, Hyperplasia | 1 1 2 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + A + + +|
Mineralization | 2 2 2 2 |
Mucosa, Granuloma | |
Mucosa, Hyperplasia | 2 3 |
__________________________________________________________________________|
Tooth | + + |
Incisor, Developmental Malformation | 3 |
Incisor, Inflammation, Chronic Active| 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 1| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 7| 2| 5| 2| 5| 2| 2| 0| 2| 2| 0| 2| 7| 4| 7| 2| 2| 2| 4| 2| 2| 6| 2| 2| 2|
| 1| 3| 1| 3| 9| 3| 4| 0| 3| 4| 3| 4| 2| 8| 3| 5| 4| 4| 7| 5| 5| 9| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Atrioventricular Valve, Inflammation,| |
Chronic | |
Interstitium, Fibrosis | 1 3 1 1 |
Myocardium, Degeneration | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus, Focal | 2 |
Clear Cell Focus | |
Hematocyst | |
Hemorrhage, Focal | |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 2 2 1 2 |
Extra Adrenal Tissue, Accessory | |
Adrenal Cortical Nodule | X X |
Spindle Cell, Hyperplasia | 1 1 1 2 1 2 2 1 1 2 2 2 2 1 2 1 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + A + + +|
Cyst | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + M + + + +|
Cyst | |
Ectopic Thymus | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Cyst | 1 3 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Lumen, Dilatation | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
Hemorrhage | 3 |
Hypospermia | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 1| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 7| 2| 5| 2| 5| 2| 2| 0| 2| 2| 0| 2| 7| 4| 7| 2| 2| 2| 4| 2| 2| 6| 2| 2| 2|
| 1| 3| 1| 3| 9| 3| 4| 0| 3| 4| 3| 4| 2| 8| 3| 5| 4| 4| 7| 5| 5| 9| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Abscess | |
Inflammation, Acute | 4 4 |
Inflammation, Chronic | 2 3 |
Duct, Ectasia | 4 3 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Chronic | |
Lumen, Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + A + + +|
Interstitium, Pigmentation | 2 |
Seminiferous Tubule, Atrophy | 2 |
Seminiferous Tubule, Dilatation | 2 |
Seminiferous Tubule, Giant Cell | |
Seminiferous Tubule, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + A + + +|
Erythroid Cell, Hyperplasia | 2 |
Myeloid Cell, Hyperplasia | 3 3 2 3 2|
__________________________________________________________________________|
Lymph Node | + + A + + + + + + + + + + + + + + + + + + A + + +|
Mesenteric, Angiectasis | 2 3 2 3 2 2 2|
Mesenteric, Congestion | 2 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 1 2 2 2 3 2|
Mesenteric, Hyperplasia, Lymphoid | 2 2 3 2 3 2 2 2 2 2 2|
Mesenteric, Inflammation, Acute | 2 2 2 |
Mesenteric, Pigmentation | 1 2 1 2 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + A + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + A + M + + + + + + + + + + + + + + + + A + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 3 4 |
Hyperplasia, Lymphoid | 1 1|
Capsule, Inflammation, Chronic | |
Lymphocyte, Necrosis | 2 |
__________________________________________________________________________|
Thymus | M + + M + + M + + + + + + + + + + M + M + + + + M|
Atrophy | 3 3 2 2 |
Cyst | 2 2 2 1 3 1 2 2 |
Cortex, Necrosis | 3 2 4 |
Medulla, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 1| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 7| 2| 5| 2| 5| 2| 2| 0| 2| 2| 0| 2| 7| 4| 7| 2| 2| 2| 4| 2| 2| 6| 2| 2| 2|
| 1| 3| 1| 3| 9| 3| 4| 0| 3| 4| 3| 4| 2| 8| 3| 5| 4| 4| 7| 5| 5| 9| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
Acinus, Duct, Dilatation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
Dermis, Fibrosis | 2 |
Dermis, Inflammation, Chronic | 2 1 2 2 2 2 |
Dermis, Mineralization | 2 |
Epidermis, Hyperkeratosis | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Arthrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perivascular, Fibrosis, Focal | |
Thalamus, Mineralization | 2 2 2 1 2 1 2 2 1 2 1 2 2 1 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Hemorrhage | 3 3 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + A + + +|
Exudate, Purulent | |
Inflammation, Acute | |
Nasolacrimal Duct, Exudate | |
__________________________________________________________________________|
Trachea | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | 4 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 2 1 1 2 1 1 1 2 1 2 1 1 1 1 1|
Cortex, Metaplasia, Osseous | 1 |
Renal Tubule, Dilatation | 2 2 |
Renal Tubule, Hypertrophy | |
Renal Tubule, Mineralization | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 1| 7| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 7| 2| 5| 2| 5| 2| 2| 0| 2| 2| 0| 2| 7| 4| 7| 2| 2| 2| 4| 2| 2| 6| 2| 2| 2|
| 1| 3| 1| 3| 9| 3| 4| 0| 3| 4| 3| 4| 2| 8| 3| 5| 4| 4| 7| 5| 5| 9| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urethra | + |
Inflammation, Acute | 2 |
Bulbourethral Gland, Inflammation, | |
Acute | 2 |
__________________________________________________________________________|
Urinary Bladder | + + A + A + + + + + + + + + + + + + + + + A + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6|
DAY ON TEST | 9| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 3| 3| 3| 3| 3| 4| 4| 0| 3| 4| 7| 2| 7|
| 6| 8| 8| 8| 8| 9| 9| 9| 2| 9| 2| 9| 0| 0| 0| 0| 0| 8| 8| 6| 8| 2| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + M + + + + + + + + + + + + + + + + + A + + + +|
Epithelium, Cytoplasmic Alteration | 2 |
Wall, Mucocele | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoid Tissue, Pigmentation | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 2 2 2 |
Lymphoid Tissue, Pigmentation | 2 2 1 1 1|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Hepatocyte, Necrosis | 1 1 |
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Acinar Cell, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperkeratosis | 3 1 2 |
Inflammation, Acute | |
Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + |
Mineralization | 1 1 1 |
Mucosa, Granuloma | 1 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | + + |
Incisor, Developmental Malformation | 2 2 |
Incisor, Inflammation, Chronic Active| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6|
DAY ON TEST | 9| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 3| 3| 3| 3| 3| 4| 4| 0| 3| 4| 7| 2| 7|
| 6| 8| 8| 8| 8| 9| 9| 9| 2| 9| 2| 9| 0| 0| 0| 0| 0| 8| 8| 6| 8| 2| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Atrioventricular Valve, Inflammation,| |
Chronic | 2 |
Interstitium, Fibrosis | 1 1 2 |
Myocardium, Degeneration | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + M A + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + M A + + + +|
Clear Cell Focus, Focal | |
Clear Cell Focus | 1 |
Hematocyst | 2 |
Hemorrhage, Focal | 2 |
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | 2 1 1 2 |
Extra Adrenal Tissue, Accessory | |
Adrenal Cortical Nodule | |
Spindle Cell, Hyperplasia | 1 1 2 2 1 2 2 1 3 2 2 2 2 2 2 1 2 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + M A + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +|
Cyst | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Cyst | 2 |
Ectopic Thymus | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Lumen, Dilatation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Hemorrhage | |
Hypospermia | 3 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6|
DAY ON TEST | 9| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 3| 3| 3| 3| 3| 4| 4| 0| 3| 4| 7| 2| 7|
| 6| 8| 8| 8| 8| 9| 9| 9| 2| 9| 2| 9| 0| 0| 0| 0| 0| 8| 8| 6| 8| 2| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Abscess | 3 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 3 4 |
Duct, Ectasia | 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic | 2 |
Lumen, Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitium, Pigmentation | |
Seminiferous Tubule, Atrophy | 2 1 3 |
Seminiferous Tubule, Dilatation | |
Seminiferous Tubule, Giant Cell | 2 |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +|
Erythroid Cell, Hyperplasia | 2 2 |
Myeloid Cell, Hyperplasia | 1 2 2 2 3 2 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Angiectasis | 2 1 2 2 2 2 |
Mesenteric, Congestion | |
Mesenteric, Hematopoietic Cell | |
Proliferation | 1 1 1 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 1 2 2|
Mesenteric, Inflammation, Acute | 2 2 2 |
Mesenteric, Pigmentation | 1 2 1 2 2 1 2 2 1 2 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 3 3 4 2 |
Hyperplasia, Lymphoid | 2 1 2 2 |
Capsule, Inflammation, Chronic | 2 |
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Thymus | M + + + + + M + M M + M + + M M M + M + A + + M M|
Atrophy | 3 4 3 |
Cyst | 2 1 2 1 1 |
Cortex, Necrosis | |
Medulla, Atrophy | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6|
DAY ON TEST | 9| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 3| 3| 3| 3| 3| 4| 4| 0| 3| 4| 7| 2| 7|
| 6| 8| 8| 8| 8| 9| 9| 9| 2| 9| 2| 9| 0| 0| 0| 0| 0| 8| 8| 6| 8| 2| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M + M M M M M M M M M M M M M M M M|
Acinus, Duct, Dilatation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Dermis, Fibrosis | 2 2 2|
Dermis, Inflammation, Chronic | 2 1 2 1 1 1 |
Dermis, Mineralization | 3 |
Epidermis, Hyperkeratosis | 2 |
Epithelium, Hyperplasia | 3 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Arthrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + A + + + +|
Perivascular, Fibrosis, Focal | 2 |
Thalamus, Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Purulent | 1 |
Inflammation, Acute | 1 |
Nasolacrimal Duct, Exudate | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 2 1 1 2 1 1 1 3 1 1 1 1 2 2 2 1 1 2 1 1|
Cortex, Metaplasia, Osseous | |
Renal Tubule, Dilatation | 2 2 3 |
Renal Tubule, Hypertrophy | 1 |
Renal Tubule, Mineralization | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 5| 6| 7| 6|
DAY ON TEST | 9| 2| 2| 2| 2| 2| 2| 2| 7| 2| 7| 2| 3| 3| 3| 3| 3| 4| 4| 0| 3| 4| 7| 2| 7|
| 6| 8| 8| 8| 8| 9| 9| 9| 2| 9| 2| 9| 0| 0| 0| 0| 0| 8| 8| 6| 8| 2| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urethra | |
Inflammation, Acute | |
Bulbourethral Gland, Inflammation, | |
Acute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 8| 4| 3| 4| 4| 4| 3| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 43 |
Epithelium, Cytoplasmic Alteration | | 2 2.5|
Wall, Mucocele | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 46 |
Lymphoid Tissue, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 46 |
__________________________________________________________________________|____________|
Intestine Small | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 45 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 45 |
Lymphoid Tissue, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 45 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 7 2.4|
Lymphoid Tissue, Pigmentation | | 10 1.5|
__________________________________________________________________________|____________|
Liver | | 49 |
Basophilic Focus | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Hepatocyte, Necrosis | | 3 1.0|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | | 47 |
Acinar Cell, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 48 |
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 48 |
Hyperkeratosis | | 5 1.8|
Inflammation, Acute | | 3 1.3|
Epithelium, Hyperplasia | | 7 1.9|
__________________________________________________________________________|____________|
Stomach, Glandular | | 44 |
Mineralization | | 7 1.6|
Mucosa, Granuloma | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 8| 4| 3| 4| 4| 4| 3| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Tooth | | 4 |
Incisor, Developmental Malformation | | 3 2.3|
Incisor, Inflammation, Chronic Active| | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Inflammation, Acute | | 1 2.0|
Atrioventricular Valve, Inflammation,| | |
Chronic | | 1 2.0|
Interstitium, Fibrosis | | 7 1.4|
Myocardium, Degeneration | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 48 |
Clear Cell Focus, Focal | | 1 2.0|
Clear Cell Focus | | 1 1.0|
Hematocyst | | 1 2.0|
Hemorrhage, Focal | | 1 2.0|
Hyperplasia, Focal | | 2 2.0|
Hypertrophy, Focal | | 9 1.7|
Extra Adrenal Tissue, Accessory | | |
Adrenal Cortical Nodule | | 2 |
Spindle Cell, Hyperplasia | | 41 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 48 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 47 |
Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 47 |
Cyst | | 1 2.0|
Ectopic Thymus | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 48 |
Pars Distalis, Cyst | | 3 2.0|
Pars Distalis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicle, Cyst | | 3 2.0|
Follicular Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 8| 4| 3| 4| 4| 4| 3| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Lumen, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | | 50 |
Granuloma Sperm | | 2 2.5|
Hemorrhage | | 1 3.0|
Hypospermia | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 11 |
Abscess | | 1 3.0|
Inflammation, Acute | | 3 3.3|
Inflammation, Chronic | | 4 3.0|
Duct, Ectasia | | 8 2.8|
__________________________________________________________________________|____________|
Prostate | | 48 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 48 |
Inflammation, Chronic | | 1 2.0|
Lumen, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | | 49 |
Interstitium, Pigmentation | | 1 2.0|
Seminiferous Tubule, Atrophy | | 4 2.0|
Seminiferous Tubule, Dilatation | | 1 2.0|
Seminiferous Tubule, Giant Cell | | 1 2.0|
Seminiferous Tubule, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 48 |
Erythroid Cell, Hyperplasia | | 3 2.0|
Myeloid Cell, Hyperplasia | | 12 2.2|
__________________________________________________________________________|____________|
Lymph Node | | 48 |
Mesenteric, Angiectasis | | 13 2.1|
Mesenteric, Congestion | | 1 2.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 9 1.7|
Mesenteric, Hyperplasia, Lymphoid | | 22 2.0|
Mesenteric, Inflammation, Acute | | 6 2.0|
Mesenteric, Pigmentation | | 16 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 8| 4| 3| 4| 4| 4| 3| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | | 47 |
Hematopoietic Cell Proliferation | | 16 2.5|
Hyperplasia, Lymphoid | | 6 1.5|
Capsule, Inflammation, Chronic | | 1 2.0|
Lymphocyte, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 32 |
Atrophy | | 7 2.9|
Cyst | | 13 1.7|
Cortex, Necrosis | | 3 3.0|
Medulla, Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 1 |
Acinus, Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Ulcer | | 2 3.0|
Dermis, Fibrosis | | 4 2.0|
Dermis, Inflammation, Chronic | | 12 1.6|
Dermis, Mineralization | | 2 2.5|
Epidermis, Hyperkeratosis | | 1 2.0|
Epithelium, Hyperplasia | | 3 2.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Joint, Arthrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
Perivascular, Fibrosis, Focal | | 1 2.0|
Thalamus, Mineralization | | 34 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 2 2.5|
Hemorrhage | | 2 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 49 |
Exudate, Purulent | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 8| 4| 3| 4| 4| 4| 3| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 1.0|
Nasolacrimal Duct, Exudate | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Phthisis Bulbi | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Nephropathy | | 37 1.4|
Cortex, Metaplasia, Osseous | | 1 1.0|
Renal Tubule, Dilatation | | 5 2.2|
Renal Tubule, Hypertrophy | | 1 1.0|
Renal Tubule, Mineralization | | 10 1.1|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Acute | | 1 2.0|
Bulbourethral Gland, Inflammation, | | |
Acute | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 46 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 6| 6| 7| 7| 0| 0| 0|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 4| 0| 2| 2| 9| 2| 8| 2| 8| 2| 1| 4| 2| 2| 8| 8| 8|
| 3| 3| 1| 3| 2| 3| 1| 5| 7| 3| 4| 3| 0| 4| 7| 0| 5| 4| 7| 8| 4| 4| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + A + + + + A + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + A + + A + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + A + + + + + + + + + + A + + + + + +|
Lymphoid Tissue, Pigmentation | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + A + + + + + + + + + + A + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 |
Lymphoid Tissue, Hyperplasia | 2 |
Lymphoid Tissue, Inflammation, | |
Chronic | 2 |
Lymphoid Tissue, Pigmentation | 2 1 1 1 1 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 2 2 |
Hepatocyte, Necrosis | 2 2 2 2|
Hepatocyte, Vacuolization Cytoplasmic| 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Congestion | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 2 |
Inflammation, Acute | 2 |
Ulcer | 1 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Mineralization | 2 1 |
__________________________________________________________________________|
Tooth | + |
Incisor, Developmental Malformation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Carotid Artery, Aneurysm | 4 |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 6| 6| 7| 7| 0| 0| 0|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 4| 0| 2| 2| 9| 2| 8| 2| 8| 2| 1| 4| 2| 2| 8| 8| 8|
| 3| 3| 1| 3| 2| 3| 1| 5| 7| 3| 4| 3| 0| 4| 7| 0| 5| 4| 7| 8| 4| 4| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Interstitium, Fibrosis | |
Myocardium, Degeneration | 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2 2 1 |
Necrosis | 4 |
Spindle Cell, Hyperplasia | 2 1 2 1 1 2 1 2 1 1|
Unilateral, Atrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Unilateral, Necrosis | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M M + + + + + +|
Cyst | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Unilateral, Necrosis | 3 |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Preputial Gland | + + + |
Abscess | |
Duct, Ectasia | 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + +|
Polyarteritis, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 6| 6| 7| 7| 0| 0| 0|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 4| 0| 2| 2| 9| 2| 8| 2| 8| 2| 1| 4| 2| 2| 8| 8| 8|
| 3| 3| 1| 3| 2| 3| 1| 5| 7| 3| 4| 3| 0| 4| 7| 0| 5| 4| 7| 8| 4| 4| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Seminiferous Tubule, Atrophy | |
Seminiferous Tubule, Giant Cell | 1 |
Unilateral, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Plasma Cell | |
Inguinal, Lymphocyte, Necrosis | 3 |
Mesenteric, Angiectasis | 1 2 |
Mesenteric, Congestion | 3 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 1 1 1 2 2 |
Mesenteric, Hyperplasia, Lymphoid | 1 2 2 2 1 2 |
Mesenteric, Inflammation, Acute | 2 |
Mesenteric, Inflammation, Chronic | 4 |
Mesenteric, Pigmentation | 1 2 1 1 3 2 |
Mesenteric, Lymphocyte, Necrosis | 3 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Pigmentation | 2 |
Lymphocyte, Necrosis | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 3 3 3 4 3 3 2 |
Hyperplasia, Lymphoid | |
Lymphocyte, Necrosis | 2 1|
__________________________________________________________________________|
Thymus | M + + + + M + M + + + + + + M|
Atrophy | 3 |
Cyst | 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 4 |
Dermis, Inflammation, Chronic | 2 2 2 2 2 2 |
Epithelium, Hyperplasia | |
Prepuce, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 5| 7| 6| 5| 5| 7| 6| 6| 7| 7| 0| 0| 0|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 0| 4| 0| 2| 2| 9| 2| 8| 2| 8| 2| 1| 4| 2| 2| 8| 8| 8|
| 3| 3| 1| 3| 2| 3| 1| 5| 7| 3| 4| 3| 0| 4| 7| 0| 5| 4| 7| 8| 4| 4| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 1 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Peribronchiolar, Cyst | 2 |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Exudate, Purulent | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Infarct, Chronic | 4 1 |
Nephropathy | 1 1 1 1 1 3 3 2 2|
Cortex, Metaplasia, Osseous | |
Medulla, Congestion | 3 2|
Renal Tubule, Dilatation | |
Renal Tubule, Mineralization | 1 |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Ectasia | |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 3| 7| 4| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 2| 5| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 8| 1| 2| 2| 2| 1| 3| 3|
| 9| 5| 2| 5| 8| 5| 8| 8| 5| 5| 9| 9| 8| 8| 8| 9| 7| 3| 9| 9| 9| 9| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Gallbladder | M + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Pigmentation | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 2 2 3 2 2 |
Lymphoid Tissue, Hyperplasia | |
Lymphoid Tissue, Inflammation, | |
Chronic | |
Lymphoid Tissue, Pigmentation | 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Hematopoietic Cell Proliferation | |
Hepatocyte, Necrosis | 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Congestion | 2 |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Acute | |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic | 2 1 |
Mineralization | 1 2 |
__________________________________________________________________________|
Tooth | |
Incisor, Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Carotid Artery, Aneurysm | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 3| 7| 4| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 2| 5| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 8| 1| 2| 2| 2| 1| 3| 3|
| 9| 5| 2| 5| 8| 5| 8| 8| 5| 5| 9| 9| 8| 8| 8| 9| 7| 3| 9| 9| 9| 9| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Interstitium, Fibrosis | 1 1 |
Myocardium, Degeneration | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 |
Necrosis | |
Spindle Cell, Hyperplasia | 2 1 1 1 1 |
Unilateral, Atrophy | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + |
Hyperplasia, Focal | |
Unilateral, Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + |
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
Inflammation, Acute | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + |
Inflammation, Chronic | 1 1 |
Unilateral, Necrosis | |
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Abscess | 4 |
Duct, Ectasia | 4 3 4 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + |
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
Depletion Cellular | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + |
Polyarteritis, Chronic | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 3| 7| 4| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 2| 5| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 8| 1| 2| 2| 2| 1| 3| 3|
| 9| 5| 2| 5| 8| 5| 8| 8| 5| 5| 9| 9| 8| 8| 8| 9| 7| 3| 9| 9| 9| 9| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Seminiferous Tubule, Atrophy | 1 1 |
Seminiferous Tubule, Giant Cell | |
Unilateral, Necrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Plasma Cell | 2 |
Inguinal, Lymphocyte, Necrosis | 2 |
Mesenteric, Angiectasis | 2 1 1 3 2 2 2 |
Mesenteric, Congestion | |
Mesenteric, Hematopoietic Cell | |
Proliferation | 1 2 1 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 1 2 2 1 2|
Mesenteric, Inflammation, Acute | |
Mesenteric, Inflammation, Chronic | |
Mesenteric, Pigmentation | 1 1 1 2 1 1 1 1|
Mesenteric, Lymphocyte, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + |
Hyperplasia, Lymphoid | 2 |
Pigmentation | |
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + |
Angiectasis | |
Hematopoietic Cell Proliferation | 2 3 4 3 3 3 |
Hyperplasia, Lymphoid | 2 2 1 |
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Thymus | + M + M M M + M |
Atrophy | 2 1 |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Dermis, Inflammation, Chronic | 1 2 2 2 1 2 1|
Epithelium, Hyperplasia | 3 2 |
Prepuce, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 3| 7| 4| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 2| 5| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 8| 1| 2| 2| 2| 1| 3| 3|
| 9| 5| 2| 5| 8| 5| 8| 8| 5| 5| 9| 9| 8| 8| 8| 9| 7| 3| 9| 9| 9| 9| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Thalamus, Mineralization | 2 1 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Peribronchiolar, Cyst | |
Pleura, Inflammation, Chronic | 1|
__________________________________________________________________________|
Nose | + + + + + + + + |
Exudate, Purulent | |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
Infarct, Chronic | 2 |
Nephropathy | 1 2 1 |
Cortex, Metaplasia, Osseous | 1 |
Medulla, Congestion | |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Ectasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + |
Inflammation, Chronic | 2 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 3| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 9| 6| 6| 0| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 4| 7| 3| 3| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 23 |
__________________________________________________________________________|____________|
Gallbladder | | 20 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Small | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 47 |
Lymphoid Tissue, Pigmentation | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 47 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 7 2.1|
Lymphoid Tissue, Hyperplasia | | 1 2.0|
Lymphoid Tissue, Inflammation, | | |
Chronic | | 1 2.0|
Lymphoid Tissue, Pigmentation | | 14 1.2|
__________________________________________________________________________|____________|
Liver | | 50 |
Clear Cell Focus | | 1 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hepatocyte, Necrosis | | 6 2.0|
Hepatocyte, Vacuolization Cytoplasmic| | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Congestion | | 1 2.0|
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | | 25 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | | 22 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperkeratosis | | 3 2.0|
Inflammation, Acute | | 1 2.0|
Ulcer | | 1 1.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 2 1.5|
Mineralization | | 4 1.5|
__________________________________________________________________________|____________|
Tooth | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 3| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 9| 6| 6| 0| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 4| 7| 3| 3| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Incisor, Developmental Malformation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Carotid Artery, Aneurysm | | 1 4.0|
__________________________________________________________________________|____________|
Heart | | 23 |
Interstitium, Fibrosis | | 2 1.0|
Myocardium, Degeneration | | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 23 |
Hyperplasia, Focal | | 1 2.0|
Hypertrophy, Focal | | 4 1.8|
Necrosis | | 1 4.0|
Spindle Cell, Hyperplasia | | 15 1.3|
Unilateral, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 23 |
Hyperplasia, Focal | | 1 1.0|
Unilateral, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 23 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 20 |
Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 22 |
__________________________________________________________________________|____________|
Thyroid Gland | | 23 |
Inflammation, Acute | | 1 1.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 23 |
Inflammation, Chronic | | 2 1.0|
Unilateral, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | | 9 |
Abscess | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 3| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 9| 6| 6| 0| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 4| 7| 3| 3| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Ectasia | | 7 3.1|
__________________________________________________________________________|____________|
Prostate | | 23 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 25 |
Depletion Cellular | | 1 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Testes | | 23 |
Polyarteritis, Chronic | | 1 1.0|
Seminiferous Tubule, Atrophy | | 2 1.0|
Seminiferous Tubule, Giant Cell | | 1 1.0|
Unilateral, Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 22 |
Myeloid Cell, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Iliac, Hyperplasia, Plasma Cell | | 1 2.0|
Inguinal, Lymphocyte, Necrosis | | 2 2.5|
Mesenteric, Angiectasis | | 9 1.8|
Mesenteric, Congestion | | 1 3.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 8 1.4|
Mesenteric, Hyperplasia, Lymphoid | | 16 1.8|
Mesenteric, Inflammation, Acute | | 1 2.0|
Mesenteric, Inflammation, Chronic | | 1 4.0|
Mesenteric, Pigmentation | | 14 1.4|
Mesenteric, Lymphocyte, Necrosis | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 21 |
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | | 1 2.0|
Lymphocyte, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | | 26 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | | 13 3.0|
Hyperplasia, Lymphoid | | 3 1.7|
Lymphocyte, Necrosis | | 2 1.5|
__________________________________________________________________________|____________|
Thymus | | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 3| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 9| 6| 6| 0| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 4| 7| 3| 3| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atrophy | | 3 2.0|
Cyst | | 3 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | | 48 |
Ulcer | | 3 3.3|
Dermis, Inflammation, Chronic | | 13 1.8|
Epithelium, Hyperplasia | | 2 2.5|
Prepuce, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 23 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 23 |
Thalamus, Mineralization | | 9 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 3 2.3|
Peribronchiolar, Cyst | | 1 2.0|
Pleura, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 23 |
Exudate, Purulent | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | | 23 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 23 |
Infarct, Chronic | | 3 2.3|
Nephropathy | | 12 1.6|
Cortex, Metaplasia, Osseous | | 1 1.0|
Medulla, Congestion | | 2 2.5|
Renal Tubule, Dilatation | | 1 3.0|
Renal Tubule, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 3| 4| 4| 2| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 9| 6| 6| 0| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 4| 7| 3| 3| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Bulbourethral Gland, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 22 |
Inflammation, Chronic | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 3| 3| 7| 7| 7| 0| 1| 7| 7| 7| 6| 4| 7| 5| 5| 4| 6| 7| 7| 6| 0| 1| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 2| 2| 3| 6| 2| 2| 2| 1| 3| 2| 2| 9| 7| 8| 2| 2| 4| 7| 2| 2| 2| 2|
| 7| 8| 3| 1| 3| 5| 8| 3| 3| 3| 7| 6| 4| 4| 8| 2| 7| 2| 4| 7| 3| 2| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + M + + + M A + + A |
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + A + + + + + + + + + + + + + + A + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + M A + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + M A + + + + + + + + + + + + + + A + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + M A + + + + M + + + + + M + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + M A + + + + + + + + + + A + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + M A + + + + M + + + + + A + + + A + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
Lymphoid Tissue, Pigmentation | 1 1 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Inflammation, Chronic | |
Hepatocyte, Necrosis | 1 1 1 |
Sinusoid, Dilatation | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Infiltration Cellular, Mast Cell | 2|
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Mineralization | 1 2 1 1 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | + |
Incisor, Developmental Malformation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + |
Inflammation, Acute | |
Atrium, Thrombosis | 3 |
Endocardium, Inflammation, Acute | |
Interstitium, Fibrosis | 1 |
Myocardium, Degeneration | |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 3| 3| 7| 7| 7| 0| 1| 7| 7| 7| 6| 4| 7| 5| 5| 4| 6| 7| 7| 6| 0| 1| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 2| 2| 3| 6| 2| 2| 2| 1| 3| 2| 2| 9| 7| 8| 2| 2| 4| 7| 2| 2| 2| 2|
| 7| 8| 3| 1| 3| 5| 8| 3| 3| 3| 7| 6| 4| 4| 8| 2| 7| 2| 4| 7| 3| 2| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + |
Hypertrophy, Focal | 1 |
Spindle Cell, Hyperplasia | 2 1 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M A |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + M M |
Cyst | |
__________________________________________________________________________|
Pituitary Gland | M + + + + M + + + + + + + + |
Pars Distalis, Congestion | 3 |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + M M |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Penis | + |
Cyst | 2 |
__________________________________________________________________________|
Preputial Gland | + +|
Abscess | 3|
Inflammation, Chronic | |
Duct, Ectasia | 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + |
Inflammation, Acute | 3 3 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + |
Depletion Cellular | |
Inflammation, Acute | 2 2 |
Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + A + + + + + |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Autolysis | 4 |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 3| 3| 7| 7| 7| 0| 1| 7| 7| 7| 6| 4| 7| 5| 5| 4| 6| 7| 7| 6| 0| 1| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 2| 2| 3| 6| 2| 2| 2| 1| 3| 2| 2| 9| 7| 8| 2| 2| 4| 7| 2| 2| 2| 2|
| 7| 8| 3| 1| 3| 5| 8| 3| 3| 3| 7| 6| 4| 4| 8| 2| 7| 2| 4| 7| 3| 2| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Hematopoietic Cell | |
Proliferation | 3 |
Inguinal, Hyperplasia, Plasma Cell | 2 |
Inguinal, Lymphocyte, Necrosis | 2 |
Mesenteric, Angiectasis | 2 2|
Mesenteric, Autolysis | 4 4 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 2 3 2 1 1 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 1 2 1|
Mesenteric, Inflammation, Acute | 2 2 1|
Mesenteric, Pigmentation | 1 2 2 1 |
Mesenteric, Thrombosis | 2 3 |
Mesenteric, Lymphocyte, Necrosis | |
Renal, Lymphocyte, Hyperplasia | 3 |
Renal, Lymphocyte, Necrosis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + M + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + M |
Angiectasis | |
Hematopoietic Cell Proliferation | 2 2 3 3 4 2 3 |
Hyperplasia, Lymphoid | |
Lymphocyte, Depletion Cellular | 2 |
Lymphocyte, Necrosis | 2 |
Red Pulp, Depletion Cellular | |
__________________________________________________________________________|
Thymus | M M + + M M M M M M M + + + |
Atrophy | 2 3 3 |
Cyst | 2 |
Cortex, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 4 3 |
Dermis, Inflammation, Chronic | 2 2 2 2 2 1 2 1 2|
Dermis, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + |
Thalamus, Mineralization | 2 1 1 2 3 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 3| 3| 7| 7| 7| 0| 1| 7| 7| 7| 6| 4| 7| 5| 5| 4| 6| 7| 7| 6| 0| 1| 7| 7| 7|
DAY ON TEST | 2| 8| 2| 2| 2| 3| 6| 2| 2| 2| 1| 3| 2| 2| 9| 7| 8| 2| 2| 4| 7| 2| 2| 2| 2|
| 7| 8| 3| 1| 3| 5| 8| 3| 3| 3| 7| 6| 4| 4| 8| 2| 7| 2| 4| 7| 3| 2| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation, Acute | 2 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + |
Cyst | |
Infarct, Chronic | |
Nephropathy | 3 1 1 |
Medulla, Congestion | 2 |
Papilla, Necrosis | |
Pelvis, Inflammation, Acute | |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Hypertrophy | |
Renal Tubule, Mineralization | 2 1 1 |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A |
Inflammation, Acute | |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 7| 5| 6| 7| 7| 1| 1| 4| 4| 6| 7| 7| 6| 7| 7| 0| 0| 5| 7| 7|
DAY ON TEST | 2| 1| 8| 2| 4| 2| 8| 0| 2| 2| 1| 2| 2| 2| 7| 2| 2| 4| 2| 2| 8| 7| 1| 2| 2|
| 5| 9| 0| 5| 4| 2| 1| 3| 5| 1| 5| 5| 1| 2| 3| 8| 5| 8| 5| 2| 7| 9| 5| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A A + + + + + A + A + + + A A + A A|
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + + A + + + + + + + + A + A + A|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + A + + + + + + + + A + A + A|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + A + + + + + + + + A + A + A|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + A + + + + + + + + A + A + A|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + A + + + + + + + A A + A + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + A A + + + + + + A + A + + + + + + + A A + A + A|
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + + + + + A + + + + + + + A A + A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + A A + + + + + + + + A + + + + + + + A A + A + A|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 3 |
Lymphoid Tissue, Pigmentation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 |
Inflammation, Chronic | 2 1 |
Hepatocyte, Necrosis | 1 1 2 1 2 |
Sinusoid, Dilatation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + A|
Hyperkeratosis | 1 |
Infiltration Cellular, Mast Cell | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + A|
Inflammation, Acute | |
Mineralization | 1 1 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | + + |
Incisor, Developmental Malformation | 3 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 4 |
Atrium, Thrombosis | |
Endocardium, Inflammation, Acute | 2 |
Interstitium, Fibrosis | 2 1|
Myocardium, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 7| 5| 6| 7| 7| 1| 1| 4| 4| 6| 7| 7| 6| 7| 7| 0| 0| 5| 7| 7|
DAY ON TEST | 2| 1| 8| 2| 4| 2| 8| 0| 2| 2| 1| 2| 2| 2| 7| 2| 2| 4| 2| 2| 8| 7| 1| 2| 2|
| 5| 9| 0| 5| 4| 2| 1| 3| 5| 1| 5| 5| 1| 2| 3| 8| 5| 8| 5| 2| 7| 9| 5| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 1 |
Spindle Cell, Hyperplasia | 2 1 2 1 2 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + M M +|
Cyst | 2 1 |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + +|
Pars Distalis, Congestion | |
Pars Distalis, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Cyst | |
__________________________________________________________________________|
Preputial Gland | + + + + |
Abscess | |
Inflammation, Chronic | 4 3 4 |
Duct, Ectasia | 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 2 |
Inflammation, Chronic | 3 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + M + + + + + + + + +|
Depletion Cellular | 3 |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Autolysis | |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 7| 5| 6| 7| 7| 1| 1| 4| 4| 6| 7| 7| 6| 7| 7| 0| 0| 5| 7| 7|
DAY ON TEST | 2| 1| 8| 2| 4| 2| 8| 0| 2| 2| 1| 2| 2| 2| 7| 2| 2| 4| 2| 2| 8| 7| 1| 2| 2|
| 5| 9| 0| 5| 4| 2| 1| 3| 5| 1| 5| 5| 1| 2| 3| 8| 5| 8| 5| 2| 7| 9| 5| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Hematopoietic Cell | |
Proliferation | |
Inguinal, Hyperplasia, Plasma Cell | 2 |
Inguinal, Lymphocyte, Necrosis | 1 |
Mesenteric, Angiectasis | 2 1 3 2 1 3|
Mesenteric, Autolysis | |
Mesenteric, Hematopoietic Cell | |
Proliferation | 2 2 1 2 1 |
Mesenteric, Hyperplasia, Lymphoid | 2 1 2 3 2 |
Mesenteric, Inflammation, Acute | 2 |
Mesenteric, Pigmentation | 1 1 1 1 |
Mesenteric, Thrombosis | |
Mesenteric, Lymphocyte, Necrosis | 1 2 |
Renal, Lymphocyte, Hyperplasia | |
Renal, Lymphocyte, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + M + + + + + + + M +|
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 3 2 4 4 3 3 2 |
Hyperplasia, Lymphoid | 2 1 |
Lymphocyte, Depletion Cellular | |
Lymphocyte, Necrosis | 2 2 |
Red Pulp, Depletion Cellular | 2 |
__________________________________________________________________________|
Thymus | + + + + M M + + + M + + M + + M + +|
Atrophy | 2 2 2 3 3 3 2|
Cyst | 1 |
Cortex, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M A|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Dermis, Inflammation, Chronic | 1 2 2 2 2 2 2 |
Dermis, Mineralization | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 2 2 2 2 1 3 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
_____________________________________________________________________________________________________________________
| 7| 7| 3| 7| 6| 7| 5| 6| 7| 7| 1| 1| 4| 4| 6| 7| 7| 6| 7| 7| 0| 0| 5| 7| 7|
DAY ON TEST | 2| 1| 8| 2| 4| 2| 8| 0| 2| 2| 1| 2| 2| 2| 7| 2| 2| 4| 2| 2| 8| 7| 1| 2| 2|
| 5| 9| 0| 5| 4| 2| 1| 3| 5| 1| 5| 5| 1| 2| 3| 8| 5| 8| 5| 2| 7| 9| 5| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infarct, Chronic | 2 2 |
Nephropathy | 3 1 3 1 2 2 3 1 1|
Medulla, Congestion | |
Papilla, Necrosis | 3 |
Pelvis, Inflammation, Acute | 2 3 |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Hypertrophy | 1 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urethra | + |
Calculus Micro Observation Only | 4 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + A|
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
Transitional Epithelium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 4| 4| 4| 4| 0| 1| 4| | |
DAY ON TEST | 6| 6| 5| 6| 6| 6| 6| 8| 8| 6| | |
| 3| 3| 8| 4| 4| 4| 4| 5| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 32 |
__________________________________________________________________________|____________|
Gallbladder | | 20 |
__________________________________________________________________________|____________|
Intestine Large | | 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 42 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 42 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 41 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | | 42 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 36 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 39 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 37 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 2 2.5|
Lymphoid Tissue, Pigmentation | | 4 1.5|
__________________________________________________________________________|____________|
Liver | | 50 |
Hematopoietic Cell Proliferation | | 7 2.0|
Inflammation, Chronic | | 2 1.5|
Hepatocyte, Necrosis | | 8 1.3|
Sinusoid, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | | 31 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 32 |
__________________________________________________________________________|____________|
Stomach | | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 48 |
Hyperkeratosis | | 1 1.0|
Infiltration Cellular, Mast Cell | | 1 2.0|
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 48 |
Inflammation, Acute | | 1 1.0|
Mineralization | | 7 1.3|
Mucosa, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 3 |
Incisor, Developmental Malformation | | 3 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 4| 4| 4| 4| 0| 1| 4| | |
DAY ON TEST | 6| 6| 5| 6| 6| 6| 6| 8| 8| 6| | |
| 3| 3| 8| 4| 4| 4| 4| 5| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation, Acute | | 2 3.0|
Atrium, Thrombosis | | 1 3.0|
Endocardium, Inflammation, Acute | | 1 2.0|
Interstitium, Fibrosis | | 3 1.3|
Myocardium, Degeneration | | 1 1.0|
Myocardium, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 32 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 32 |
Hypertrophy, Focal | | 2 1.0|
Spindle Cell, Hyperplasia | | 21 1.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 32 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 30 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 26 |
Cyst | | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | | 29 |
Pars Distalis, Congestion | | 1 3.0|
Pars Distalis, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 30 |
Ultimobranchial Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 32 |
__________________________________________________________________________|____________|
Penis | | 1 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 6 |
Abscess | | 1 3.0|
Inflammation, Chronic | | 3 3.7|
Duct, Ectasia | | 4 2.5|
__________________________________________________________________________|____________|
Prostate | | 32 |
Inflammation, Acute | | 5 2.4|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 4| 4| 4| 4| 0| 1| 4| | |
DAY ON TEST | 6| 6| 5| 6| 6| 6| 6| 8| 8| 6| | |
| 3| 3| 8| 4| 4| 4| 4| 5| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Depletion Cellular | | 1 3.0|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Testes | | 32 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 31 |
Myeloid Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Inguinal, Autolysis | | 1 4.0|
Inguinal, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Inguinal, Hyperplasia, Plasma Cell | | 2 2.0|
Inguinal, Lymphocyte, Necrosis | | 2 1.5|
Mesenteric, Angiectasis | | 8 2.0|
Mesenteric, Autolysis | | 2 4.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 10 1.7|
Mesenteric, Hyperplasia, Lymphoid | | 10 1.8|
Mesenteric, Inflammation, Acute | | 4 1.8|
Mesenteric, Pigmentation | | 8 1.3|
Mesenteric, Thrombosis | | 2 2.5|
Mesenteric, Lymphocyte, Necrosis | | 2 1.5|
Renal, Lymphocyte, Hyperplasia | | 1 3.0|
Renal, Lymphocyte, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 27 |
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | | 31 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | | 15 2.8|
Hyperplasia, Lymphoid | | 2 1.5|
Lymphocyte, Depletion Cellular | | 1 2.0|
Lymphocyte, Necrosis | | 3 2.0|
Red Pulp, Depletion Cellular | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 18 |
Atrophy | | 10 2.5|
Cyst | | 2 1.5|
Cortex, Necrosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 4| 4| 4| 4| 0| 1| 4| | |
DAY ON TEST | 6| 6| 5| 6| 6| 6| 6| 8| 8| 6| | |
| 3| 3| 8| 4| 4| 4| 4| 5| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | | 50 |
Ulcer | | 4 3.0|
Dermis, Inflammation, Chronic | | 16 1.8|
Dermis, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 32 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 32 |
Thalamus, Mineralization | | 14 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 49 |
Congestion | | 3 2.3|
Inflammation, Acute | | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 32 |
__________________________________________________________________________|____________|
Trachea | | 32 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 33 |
Cyst | | 1 2.0|
Infarct, Chronic | | 2 2.0|
Nephropathy | | 12 1.8|
Medulla, Congestion | | 1 2.0|
Papilla, Necrosis | | 1 3.0|
Pelvis, Inflammation, Acute | | 2 2.5|
Renal Tubule, Dilatation | | 2 2.0|
Renal Tubule, Hypertrophy | | 1 1.0|
Renal Tubule, Mineralization | | 3 1.3|
__________________________________________________________________________|____________|
Urethra | | 1 |
Calculus Micro Observation Only | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 28 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 05021-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:50:29
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 4| 4| 4| 4| 0| 1| 4| | |
DAY ON TEST | 6| 6| 5| 6| 6| 6| 6| 8| 8| 6| | |
| 3| 3| 8| 4| 4| 4| 4| 5| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
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---------- END OF REPORT ----------
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