TDMS Study 05021-03 Pathology Tables
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
Facility: Southern Research Institute
Chemical CAS #: 6471-49-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|
DAY ON TEST | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|
| 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|
DAY ON TEST | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|
| 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + M + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Polyp Stromal | X X X X X|
Endometrium, Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | + + + + + |
Fibrosarcoma | |
Leiomyosarcoma | X |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Mesenteric, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Thymoma Benign | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Fibroadenoma | X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glioma NOS | X |
Oligodendroglioma NOS | X |
Meninges, Granular Cell Tumor Benign | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|
DAY ON TEST | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|
| 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Polyp Stromal | X X |
Endometrium, Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | + + + |
Fibrosarcoma | X |
Leiomyosarcoma | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Mesenteric, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glioma NOS | |
Oligodendroglioma NOS | |
Meninges, Granular Cell Tumor Benign | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Adenoma | | 1 |
Leukemia Mononuclear | | 13 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 49 |
Leukemia Mononuclear | | 2 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 1 |
Bilateral, Pheochromocytoma Benign | | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Adenoma | | 29 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Adenoma | | 5 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 47 |
Adenoma | | 5 |
Carcinoma | | 3 |
__________________________________________________________________________|____________|
Ovary | | 50 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Endometrium, Polyp Stromal | | 7 |
Endometrium, Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 8 |
Fibrosarcoma | | 1 |
Leiomyosarcoma | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Axillary, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Mesenteric, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Leukemia Mononuclear | | 13 |
__________________________________________________________________________|____________|
Thymus | | 49 |
Leukemia Mononuclear | | 1 |
Thymoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Carcinoma | | 1 |
Fibroadenoma | | 23 |
__________________________________________________________________________|____________|
Skin | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Keratoacanthoma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Glioma NOS | | 1 |
Oligodendroglioma NOS | | 1 |
Meninges, Granular Cell Tumor Benign | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia Mononuclear | | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Mesentery | + + + |
Carcinoma | X |
Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Polyp Stromal | X X X X X X X |
__________________________________________________________________________|
Vagina | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Thymus | I + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Fibroadenoma | X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | X X |
Leukemia Mononuclear | |
Meningioma Malignant | X |
Choroid Plexus, Meningioma Malignant,| |
Metastatic, Brain | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Mesentery | + + |
Carcinoma | |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | X X X|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Polyp Stromal | X X X X X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Fibroadenoma | X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + M + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | X |
Leukemia Mononuclear | X |
Meningioma Malignant | |
Choroid Plexus, Meningioma Malignant,| |
Metastatic, Brain | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 8| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Adenoma | | 1 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Mesentery | | 5 |
Carcinoma | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Leiomyosarcoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Adenoma | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Leukemia Mononuclear | | 1 |
Pheochromocytoma Benign | | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Adenoma | | 3 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 8| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | | 18 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Adenoma | | 2 |
C-Cell, Carcinoma | | 3 |
Follicular Cell, Adenoma | | 3 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 49 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Ovary | | 50 |
Granulosa Cell Tumor Benign | | 1 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Endometrium, Polyp Stromal | | 13 |
__________________________________________________________________________|____________|
Vagina | | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Hemangioma | | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Thymus | | 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Adenoma | | 1 |
Fibroadenoma | | 19 |
__________________________________________________________________________|____________|
Skin | | 49 |
Keratoacanthoma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 8| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Astrocytoma NOS | | 3 |
Leukemia Mononuclear | | 1 |
Meningioma Malignant | | 1 |
Choroid Plexus, Meningioma Malignant,| | |
Metastatic, Brain | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 5| 5| 6| 6| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 7| 3| 3| 6| 9| 6| 8| 3| 5| 0| 3| 3| 3| 9| 5| 3| 3| 3| 8| 3| 3| 3| 3|
| 2| 5| 2| 2| 2| 4| 5| 2| 8| 2| 7| 1| 2| 2| 2| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
Fibrosarcoma, Metastatic, Uterus | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Fibrosarcoma, Metastatic, Uterus | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Mesentery | + + + +|
Carcinoma, Metastatic, Ovary | X |
Fibrosarcoma, Metastatic, Uterus | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
Pheochromocytoma Malignant | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Myxoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Ovary | + |
Carcinoma | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Ovary | X |
Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 5| 5| 6| 6| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 7| 3| 3| 6| 9| 6| 8| 3| 5| 0| 3| 3| 3| 9| 5| 3| 3| 3| 8| 3| 3| 3| 3|
| 2| 5| 2| 2| 2| 4| 5| 2| 8| 2| 7| 1| 2| 2| 2| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Leiomyoma | |
Cervix, Endometrium, Polyp Stromal | |
Endometrium, Polyp Stromal | X |
Endometrium, Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + |
Lumbar, Carcinoma, Metastatic, Ovary | X |
Renal, Carcinoma, Metastatic, Ovary | X |
__________________________________________________________________________|
Lymph Node, Mandibular | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Uterus | X |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Adenoma | X |
Fibroadenoma | X X X X X X |
__________________________________________________________________________|
Skin | + |
Sebaceous Gland, Carcinoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + |
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Ovary | X |
Carcinoma, Metastatic, Skin | X |
Fibrosarcoma, Metastatic, Uterus | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Squamous Cell Papilloma | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 5| 5| 6| 6| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 7| 3| 3| 6| 9| 6| 8| 3| 5| 0| 3| 3| 3| 9| 5| 3| 3| 3| 8| 3| 3| 3| 3|
| 2| 5| 2| 2| 2| 4| 5| 2| 8| 2| 7| 1| 2| 2| 2| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 4| 1| 3| 3| 3|
| 1| 5| 5| 5| 5| 5| 2| 2| 5| 5| 5| 5| 5| 5| 5| 8| 3| 5| 5| 5| 6| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Colon | |
Fibrosarcoma, Metastatic, Uterus | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Fibrosarcoma, Metastatic, Uterus | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Mesentery | + + + |
Carcinoma, Metastatic, Ovary | |
Fibrosarcoma, Metastatic, Uterus | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Pheochromocytoma Malignant | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mediastinum, Myxoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + M + M + +|
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Ovary | |
Carcinoma | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Ovary | |
Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 4| 1| 3| 3| 3|
| 1| 5| 5| 5| 5| 5| 2| 2| 5| 5| 5| 5| 5| 5| 5| 8| 3| 5| 5| 5| 6| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Leiomyoma | X |
Cervix, Endometrium, Polyp Stromal | X |
Endometrium, Polyp Stromal | X X X X X X|
Endometrium, Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + |
Lumbar, Carcinoma, Metastatic, Ovary | |
Renal, Carcinoma, Metastatic, Ovary | |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Uterus | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + |
Adenoma | X |
Fibroadenoma | X X X X X X X X |
__________________________________________________________________________|
Skin | + |
Sebaceous Gland, Carcinoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + |
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Ovary | |
Carcinoma, Metastatic, Skin | |
Fibrosarcoma, Metastatic, Uterus | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 4| 1| 3| 3| 3|
| 1| 5| 5| 5| 5| 5| 2| 2| 5| 5| 5| 5| 5| 5| 5| 8| 3| 5| 5| 5| 6| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 9| 9| 9| 8| 8| 8| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 1 |
Fibrosarcoma, Metastatic, Uterus | | 1 |
__________________________________________________________________________|____________|
Intestine Small | | 25 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 24 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 4 |
__________________________________________________________________________|____________|
Liver | | 50 |
Adenoma | | 1 |
Fibrosarcoma, Metastatic, Uterus | | 1 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
Carcinoma, Metastatic, Ovary | | 1 |
Fibrosarcoma, Metastatic, Uterus | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 1 |
Pheochromocytoma Malignant | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Adenoma | | 28 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | | 4 |
C-Cell, Carcinoma | | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Mediastinum, Myxoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 47 |
Adenoma | | 3 |
Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 9| 9| 9| 8| 8| 8| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Carcinoma, Metastatic, Ovary | | 1 |
Fibrosarcoma | | 1 |
Leiomyoma | | 1 |
Cervix, Endometrium, Polyp Stromal | | 1 |
Endometrium, Polyp Stromal | | 7 |
Endometrium, Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
Lumbar, Carcinoma, Metastatic, Ovary | | 1 |
Renal, Carcinoma, Metastatic, Ovary | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 1 |
__________________________________________________________________________|____________|
Spleen | | 49 |
Fibrosarcoma, Metastatic, Uterus | | 1 |
Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 32 |
Adenoma | | 2 |
Fibroadenoma | | 14 |
__________________________________________________________________________|____________|
Skin | | 2 |
Sebaceous Gland, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 10 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 9| 9| 9| 8| 8| 8| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | | 8 |
Alveolar/Bronchiolar Adenoma | | 1 |
Carcinoma, Metastatic, Ovary | | 1 |
Carcinoma, Metastatic, Skin | | 1 |
Fibrosarcoma, Metastatic, Uterus | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 44 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 3| 0| 2| 3| 3| 3| 9| 5| 2| 3| 3| 4| 1| 7| 3| 3| 0| 2| 2| 3| 3|
| 3| 9| 5| 5| 5| 7| 9| 5| 5| 5| 2| 1| 9| 5| 5| 2| 2| 3| 6| 6| 3| 7| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Acinar Cell, Adenoma | X |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
Carcinoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
Pheochromocytoma Malignant | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X|
Pars Distalis, Carcinoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + I +|
Adenoma | X X X|
__________________________________________________________________________|
Ovary | + |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 3| 0| 2| 3| 3| 3| 9| 5| 2| 3| 3| 4| 1| 7| 3| 3| 0| 2| 2| 3| 3|
| 3| 9| 5| 5| 5| 7| 9| 5| 5| 5| 2| 1| 9| 5| 5| 2| 2| 3| 6| 6| 3| 7| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Granulosa Cell Tumor NOS | |
Thecoma NOS | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Sarcoma Stromal | X |
Endometrium, Polyp Stromal | X X X |
Endometrium, Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + + |
Mesenteric, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
Fibroadenoma | X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + |
Basal Cell Carcinoma | X |
Subcutaneous Tissue, Fibroma | X |
Tail, Hemangiosarcoma | X |
Tail, Squamous Cell Papilloma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
Astrocytoma NOS | |
Glioma NOS | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 3| 0| 2| 3| 3| 3| 9| 5| 2| 3| 3| 4| 1| 7| 3| 3| 0| 2| 2| 3| 3|
| 3| 9| 5| 5| 5| 7| 9| 5| 5| 5| 2| 1| 9| 5| 5| 2| 2| 3| 6| 6| 3| 7| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + |
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 7| 8| 3| 3| 3| 1| 7| 3| 3| 3|
| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 6| 3| 6| 6| 6| 6| 4| 3| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Acinar Cell, Adenoma | X |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
Carcinoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Pheochromocytoma Malignant | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Ovary | + + + |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 7| 8| 3| 3| 3| 1| 7| 3| 3| 3|
| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 6| 3| 6| 6| 6| 6| 4| 3| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Granulosa Cell Tumor NOS | X |
Thecoma NOS | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Sarcoma Stromal | |
Endometrium, Polyp Stromal | X |
Endometrium, Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | |
Mesenteric, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
Adenoma | X X |
Carcinoma | X |
Fibroadenoma | X X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + |
Basal Cell Carcinoma | |
Subcutaneous Tissue, Fibroma | |
Tail, Hemangiosarcoma | |
Tail, Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
Astrocytoma NOS | X |
Glioma NOS | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 7| 8| 3| 3| 3| 1| 7| 3| 3| 3|
| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 6| 3| 6| 6| 6| 6| 4| 3| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + |
Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 8| 8| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Small | | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 15 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 6 |
__________________________________________________________________________|____________|
Liver | | 50 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Leukemia Mononuclear | | 2 |
Acinar Cell, Adenoma | | 2 |
__________________________________________________________________________|____________|
Stomach | | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 1 |
Pheochromocytoma Malignant | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Adenoma | | 23 |
Pars Distalis, Carcinoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Leukemia Mononuclear | | 1 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | | 4 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 8| 8| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 48 |
Adenoma | | 4 |
__________________________________________________________________________|____________|
Ovary | | 4 |
Granulosa Cell Tumor NOS | | 1 |
Thecoma NOS | | 2 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Cervix, Sarcoma Stromal | | 1 |
Endometrium, Polyp Stromal | | 4 |
Endometrium, Sarcoma Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
Mesenteric, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Leukemia Mononuclear | | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 38 |
Adenoma | | 2 |
Carcinoma | | 2 |
Fibroadenoma | | 24 |
__________________________________________________________________________|____________|
Skin | | 8 |
Basal Cell Carcinoma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Tail, Hemangiosarcoma | | 1 |
Tail, Squamous Cell Papilloma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 5 |
Astrocytoma NOS | | 1 |
Glioma NOS | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 8| 8| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | | 4 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 45 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 2 |
Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|
| 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma NOS | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Leiomyoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Fibrous Histiocytoma | |
Mesothelioma Malignant | X |
Mesothelioma NOS | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
Mesothelioma NOS | |
Acinar Cell, Adenoma | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant, Metastatic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|
| 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X|
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + |
Fibroma | X X |
Liposarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Mesothelioma NOS | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|
| 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Mesothelioma Malignant | |
Iliac, Fibrous Histiocytoma | |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Mesenteric, Fibrous Histiocytoma | |
Mesenteric, Leukemia Mononuclear | X X X X X X |
Pancreatic, Carcinoma, Metastatic, | |
Islets, Pancreatic | |
Pancreatic, Leukemia Mononuclear | X X X X X |
Renal, Fibrous Histiocytoma | |
Renal, Leukemia Mononuclear | X X X |
Renal, Mesothelioma NOS | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Keratoacanthoma | X |
Leukemia Mononuclear | |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|
| 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Meninges, Granular Cell Tumor Benign | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
Mesothelioma Malignant | X |
Mesothelioma NOS | X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|
| 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma NOS | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Leiomyoma | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Fibrous Histiocytoma | X |
Mesothelioma Malignant | X |
Mesothelioma NOS | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
Mesothelioma NOS | X |
Acinar Cell, Adenoma | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + M M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|
| 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + M M + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X X X|
Bilateral, Pheochromocytoma Benign | X X X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fibroma | |
Liposarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Mesothelioma NOS | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|
| 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood | + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +|
Bronchial, Mesothelioma Malignant | X |
Iliac, Fibrous Histiocytoma | X |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X |
Mesenteric, Fibrous Histiocytoma | X |
Mesenteric, Leukemia Mononuclear | X X X |
Pancreatic, Carcinoma, Metastatic, | |
Islets, Pancreatic | X |
Pancreatic, Leukemia Mononuclear | X X X |
Renal, Fibrous Histiocytoma | X |
Renal, Leukemia Mononuclear | |
Renal, Mesothelioma NOS | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Fibrous Histiocytoma | X |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Keratoacanthoma | |
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|
| 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Meninges, Granular Cell Tumor Benign | X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
Mesothelioma Malignant | X |
Mesothelioma NOS | X |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
Adenocarcinoma | | 1 |
Leiomyoma | | 1 |
__________________________________________________________________________|____________|
Liver | | 50 |
Fibrous Histiocytoma | | 1 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | | 2 |
Leukemia Mononuclear | | 28 |
__________________________________________________________________________|____________|
Mesentery | | 11 |
Fibrous Histiocytoma | | 1 |
Mesothelioma Malignant | | 2 |
Mesothelioma NOS | | 2 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | | 3 |
Mesothelioma Malignant | | 1 |
Mesothelioma NOS | | 1 |
Acinar Cell, Adenoma | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 3 |
Mesothelioma Malignant, Metastatic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 48 |
Adenoma | | 1 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 48 |
Leukemia Mononuclear | | 1 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 18 |
Bilateral, Pheochromocytoma Benign | | 12 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Adenoma | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | | 12 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Adenoma | | 3 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 2 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 4 |
Fibroma | | 2 |
Liposarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
Fibrous Histiocytoma | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 49 |
Adenoma | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Prostate | | 50 |
Fibrous Histiocytoma | | 1 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Fibrous Histiocytoma | | 1 |
__________________________________________________________________________|____________|
Testes | | 50 |
Bilateral, Interstitial Cell, Adenoma| | 42 |
Interstitial Cell, Adenoma | | 6 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 5 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Bronchial, Mesothelioma Malignant | | 1 |
Iliac, Fibrous Histiocytoma | | 1 |
Iliac, Leukemia Mononuclear | | 2 |
Inguinal, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 3 |
Mesenteric, Fibrous Histiocytoma | | 1 |
Mesenteric, Leukemia Mononuclear | | 9 |
Pancreatic, Carcinoma, Metastatic, | | |
Islets, Pancreatic | | 1 |
Pancreatic, Leukemia Mononuclear | | 8 |
Renal, Fibrous Histiocytoma | | 1 |
Renal, Leukemia Mononuclear | | 3 |
Renal, Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | | 28 |
__________________________________________________________________________|____________|
Thymus | | 49 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
Fibroadenoma | | 2 |
__________________________________________________________________________|____________|
Skin | | 50 |
Basal Cell Adenoma | | 1 |
Keratoacanthoma | | 1 |
Leukemia Mononuclear | | 1 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Leukemia Mononuclear | | 4 |
Meninges, Granular Cell Tumor Benign | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | | 18 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Nose | | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Leukemia Mononuclear | | 4 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | | 28 |
Mesothelioma Malignant | | 2 |
Mesothelioma NOS | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mixed Tumor Malignant, Metastatic, | |
Salivary Glands | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X |
Mesothelioma NOS | X |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Mesothelioma Malignant | |
Mesothelioma NOS | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + M + + + +|
Carcinoma, Metastatic, Stomach | |
Mesothelioma NOS | X X |
Acinar Cell, Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mixed Tumor Malignant | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Stomach | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mixed Tumor Malignant, Metastatic, | |
Salivary Glands | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | X X X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +|
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Mixed Tumor Malignant, Metastatic, | |
Salivary Glands | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X|
Pars Nervosa, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mixed Tumor Malignant, Metastatic, | |
Salivary Glands | |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X|
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + M + + + + + + + + M + + + +|
Mesothelioma Malignant | |
Mesothelioma NOS | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +|
Carcinoma, Metastatic, Stomach | |
Mesothelioma NOS | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + M + + + +|
Carcinoma, Metastatic, Stomach | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + M + + + +|
Mesothelioma NOS | X X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bronchial, Carcinoma, Metastatic, | |
Stomach | |
Deep Cervical, Lymphoma Malignant | |
Histiocytic | X |
Mesenteric, Carcinoma, Metastatic, | |
Stomach | |
Mesenteric, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Leukemia Mononuclear | X X X X |
Mesothelioma NOS | X |
__________________________________________________________________________|
Thymus | + + I + + I I + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Stomach | |
Leukemia Mononuclear | X |
Thymoma Benign | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + I + I + M + + + + + + + + + M + + +|
Fibroadenoma | X |
Fibroma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X X |
Keratoacanthoma | X X |
Squamous Cell Papilloma | |
Face, Keratoacanthoma | X |
Face, Neurofibroma | X |
Sebaceous Gland, Adenoma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Mesothelioma NOS | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Astrocytoma NOS | X |
Leukemia Mononuclear | X |
Meninges, Mixed Tumor Malignant, | |
Metastatic, Salivary Glands | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Fibrous Histiocytoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Neurofibroma | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X X |
Renal Tubule, Adenoma | X |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Histiocytic | X |
Mesothelioma Malignant | X X |
Mesothelioma NOS | X X |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|
| 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mixed Tumor Malignant, Metastatic, | |
Salivary Glands | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X|
Leukemia Mononuclear | |
Mesothelioma NOS | |
__________________________________________________________________________|
Mesentery | + + + + |
Mesothelioma Malignant | X |
Mesothelioma NOS | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Stomach | X |
Mesothelioma NOS | |
Acinar Cell, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mixed Tumor Malignant | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Stomach | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mixed Tumor Malignant, Metastatic, | |
Salivary Glands | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|
| 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X X X X X X X|
Bilateral, Pheochromocytoma Benign | X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Adenoma | X |
Mixed Tumor Malignant, Metastatic, | |
Salivary Glands | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
Pars Nervosa, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mixed Tumor Malignant, Metastatic, | |
Salivary Glands | X |
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Mesothelioma NOS | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Stomach | X |
Mesothelioma NOS | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Stomach | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma NOS | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|
| 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + M + M + + + + + + +|
Leukemia Mononuclear | |
Bronchial, Carcinoma, Metastatic, | |
Stomach | X |
Deep Cervical, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Carcinoma, Metastatic, | |
Stomach | X |
Mesenteric, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + M + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Leukemia Mononuclear | |
Mesothelioma NOS | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Stomach | X |
Leukemia Mononuclear | |
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + I + + + + + + + + + I + + + +|
Fibroadenoma | X X |
Fibroma | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Keratoacanthoma | |
Squamous Cell Papilloma | X |
Face, Keratoacanthoma | |
Face, Neurofibroma | |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | X |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Abdominal, Mesothelioma NOS | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|
| 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Astrocytoma NOS | X |
Leukemia Mononuclear | |
Meninges, Mixed Tumor Malignant, | |
Metastatic, Salivary Glands | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Fibrous Histiocytoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Neurofibroma | X |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
Renal Tubule, Adenoma | X |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Lymphoma Malignant Histiocytic | |
Mesothelioma Malignant | X |
Mesothelioma NOS | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 6| 7| 6| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
Mixed Tumor Malignant, Metastatic, | | |
Salivary Glands | | 1 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
__________________________________________________________________________|____________|
Liver | | 50 |
Fibrous Histiocytoma | | 1 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | | 2 |
Leukemia Mononuclear | | 4 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 11 |
Mesothelioma Malignant | | 1 |
Mesothelioma NOS | | 2 |
__________________________________________________________________________|____________|
Pancreas | | 49 |
Carcinoma, Metastatic, Stomach | | 1 |
Mesothelioma NOS | | 2 |
Acinar Cell, Adenoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Mixed Tumor Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Carcinoma, Metastatic, Stomach | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Leukemia Mononuclear | | 1 |
Mixed Tumor Malignant, Metastatic, | | |
Salivary Glands | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 6| 7| 6| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | | 15 |
Bilateral, Pheochromocytoma Benign | | 11 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Adenoma | | 3 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
Adenoma | | 2 |
Mixed Tumor Malignant, Metastatic, | | |
Salivary Glands | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Adenoma | | 8 |
Pars Nervosa, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Mixed Tumor Malignant, Metastatic, | | |
Salivary Glands | | 1 |
C-Cell, Adenoma | | 7 |
C-Cell, Carcinoma | | 3 |
Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 48 |
Mesothelioma Malignant | | 1 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 49 |
Adenoma | | 7 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | | 49 |
Carcinoma, Metastatic, Stomach | | 1 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 6| 7| 6| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | | 49 |
Carcinoma, Metastatic, Stomach | | 1 |
__________________________________________________________________________|____________|
Testes | | 49 |
Mesothelioma NOS | | 2 |
Bilateral, Interstitial Cell, Adenoma| | 44 |
Interstitial Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 48 |
Leukemia Mononuclear | | 1 |
Bronchial, Carcinoma, Metastatic, | | |
Stomach | | 1 |
Deep Cervical, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mesenteric, Carcinoma, Metastatic, | | |
Stomach | | 1 |
Mesenteric, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | | 4 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Thymus | | 46 |
Carcinoma, Metastatic, Stomach | | 1 |
Leukemia Mononuclear | | 1 |
Thymoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 43 |
Fibroadenoma | | 3 |
Fibroma | | 2 |
__________________________________________________________________________|____________|
Skin | | 50 |
Basal Cell Carcinoma | | 2 |
Keratoacanthoma | | 2 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 6| 7| 6| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Face, Keratoacanthoma | | 1 |
Face, Neurofibroma | | 1 |
Sebaceous Gland, Adenoma | | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | | 1 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Abdominal, Mesothelioma NOS | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Astrocytoma NOS | | 2 |
Leukemia Mononuclear | | 1 |
Meninges, Mixed Tumor Malignant, | | |
Metastatic, Salivary Glands | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Nose | | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Neurofibroma | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 6| 7| 6| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Adenoma | | 2 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia Mononuclear | | 4 |
Lymphoma Malignant Histiocytic | | 1 |
Mesothelioma Malignant | | 3 |
Mesothelioma NOS | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 9| 3| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 3| 3|
| 9| 8| 1| 2| 2| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 0| 2| 2| 1| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + |
Carcinoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + + + + + + |
Mesothelioma Malignant | X X |
Osteosarcoma, Metastatic | X |
Sarcoma | X |
__________________________________________________________________________|
Pancreas | + |
Acinar Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | |
Bilateral, Pheochromocytoma Benign | X|
__________________________________________________________________________|
Islets, Pancreatic | + |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | + + + |
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X|
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Adenoma | X X X X X |
__________________________________________________________________________|
Prostate | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 9| 3| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 3| 3|
| 9| 8| 1| 2| 2| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 0| 2| 2| 1| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Adenoma | X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + |
Axillary, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Mesenteric, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + I I + + + + + + +|
Fibroadenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + +|
Basal Cell Adenoma | |
Fibroma | |
Keratoacanthoma | X |
Squamous Cell Carcinoma | X |
Subcutaneous Tissue, Fibroma | X X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
Oligodendroglioma NOS | X |
Meninges, Granular Cell Tumor | |
Malignant | X |
Meninges, Granular Cell Tumor Benign | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + |
Carcinoma, Metastatic, Thyroid Gland | X |
Squamous Cell Carcinoma, Metastatic, | |
Skin | X |
__________________________________________________________________________|
Nose | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 9| 3| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 3| 3|
| 9| 8| 1| 2| 2| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 0| 2| 2| 1| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Renal Tubule, Carcinoma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | X X X |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 6| 2| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3|
| 7| 6| 7| 2| 2| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 3| 5| 5| 5| 5| 3| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
Carcinoma | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Mesentery | + |
Mesothelioma Malignant | |
Osteosarcoma, Metastatic | |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + |
Acinar Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
Pheochromocytoma Malignant | X |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + |
Pars Distalis, Adenoma | X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Preputial Gland | + + + |
Adenoma | X X X |
__________________________________________________________________________|
Prostate | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 6| 2| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3|
| 7| 6| 7| 2| 2| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 3| 5| 5| 5| 5| 3| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Axillary, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X |
Mesenteric, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Leukemia Mononuclear | X X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + I + + + + + + + I + I + + + + + + I + + +|
Fibroadenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + +|
Basal Cell Adenoma | X|
Fibroma | X |
Keratoacanthoma | X X |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Oligodendroglioma NOS | |
Meninges, Granular Cell Tumor | |
Malignant | |
Meninges, Granular Cell Tumor Benign | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
Carcinoma, Metastatic, Thyroid Gland | |
Squamous Cell Carcinoma, Metastatic, | |
Skin | |
__________________________________________________________________________|
Nose | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 6| 2| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3|
| 7| 6| 7| 2| 2| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 3| 5| 5| 5| 5| 3| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Renal Tubule, Carcinoma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Small | | 22 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 17 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 5 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
Mesothelioma Malignant | | 2 |
Osteosarcoma, Metastatic | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 2 |
Acinar Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 5 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | | 1 |
Bilateral, Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 2 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | | 9 |
Pars Distalis, Adenoma | | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
C-Cell, Adenoma | | 5 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Adenoma | | 8 |
__________________________________________________________________________|____________|
Prostate | | 2 |
__________________________________________________________________________|____________|
Testes | | 44 |
Mesothelioma Malignant | | 2 |
Bilateral, Interstitial Cell, Adenoma| | 41 |
Interstitial Cell, Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | | 9 |
Axillary, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 2 |
Mesenteric, Leukemia Mononuclear | | 2 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | | 48 |
Hemangioma | | 1 |
Leukemia Mononuclear | | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 44 |
Fibroadenoma | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | | 13 |
Basal Cell Adenoma | | 1 |
Fibroma | | 1 |
Keratoacanthoma | | 3 |
Squamous Cell Carcinoma | | 1 |
Subcutaneous Tissue, Fibroma | | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 4 |
Oligodendroglioma NOS | | 1 |
Meninges, Granular Cell Tumor | | |
Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Meninges, Granular Cell Tumor Benign | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 3 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Skin | | 1 |
__________________________________________________________________________|____________|
Nose | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Leukemia Mononuclear | | 1 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia Mononuclear | | 10 |
Mesothelioma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|
| 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosarcoma | |
__________________________________________________________________________|
Pancreas | A |
__________________________________________________________________________|
Salivary Glands | + |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
Fibrosarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
Carcinoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
Ganglioneuroma | |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | A |
__________________________________________________________________________|
Parathyroid Gland | + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + +|
Leukemia Mononuclear | X|
Pars Distalis, Adenoma | X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|
| 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + |
Adenoma | X |
__________________________________________________________________________|
Prostate | + + |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
Sarcoma | |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Leukemia Mononuclear | |
Mesenteric, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
Osteosarcoma, Metastatic, Bone Marrow| |
__________________________________________________________________________|
Thymus | + |
Fibrosarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + I + + + I + + + + +|
Fibroadenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + |
Adenoma | X |
Squamous Cell Papilloma | X X |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Myxoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|
| 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + |
Astrocytoma NOS | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + |
Alveolar/Bronchiolar Adenoma | X |
Fibrosarcoma, Metastatic, Skin | X |
Leukemia Mononuclear | |
Osteosarcoma, Metastatic | |
Osteosarcoma, Metastatic, Bone Marrow| |
__________________________________________________________________________|
Nose | + |
Basosquamous Tumor Benign | X |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Squamous Cell Papilloma | |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|
| 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
Fibrosarcoma | X |
__________________________________________________________________________|
Pancreas | |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Fibrosarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
Carcinoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
Ganglioneuroma | X |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|
| 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | |
__________________________________________________________________________|
Preputial Gland | + + + + +|
Adenoma | X X X X |
__________________________________________________________________________|
Prostate | + |
__________________________________________________________________________|
Seminal Vesicle | + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
Sarcoma | X |
__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Leukemia Mononuclear | X X |
Mesenteric, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
Osteosarcoma, Metastatic, Bone Marrow| X |
__________________________________________________________________________|
Thymus | |
Fibrosarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + I + + + + + + + + I|
Fibroadenoma | X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + +|
Adenoma | |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Myxoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|
| 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + |
Astrocytoma NOS | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + |
Alveolar/Bronchiolar Adenoma | |
Fibrosarcoma, Metastatic, Skin | |
Leukemia Mononuclear | X |
Osteosarcoma, Metastatic | X |
Osteosarcoma, Metastatic, Bone Marrow| X |
__________________________________________________________________________|
Nose | |
Basosquamous Tumor Benign | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 1 |
__________________________________________________________________________|____________|
Intestine Large | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 1 |
__________________________________________________________________________|____________|
Intestine Small | | 7 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | | 22 |
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fibrosarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | | |
__________________________________________________________________________|____________|
Salivary Glands | | 1 |
__________________________________________________________________________|____________|
Stomach | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 3 |
Fibrosarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 7 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 2 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 6 |
Ganglioneuroma | | 1 |
Pheochromocytoma Benign | | 2 |
Bilateral, Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | |
__________________________________________________________________________|____________|
Parathyroid Gland | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | | 16 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | | 12 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Adenoma | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Carcinoma | | 3 |
Follicular Cell, Adenoma | | 2 |
Follicular Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | | 9 |
Adenoma | | 5 |
__________________________________________________________________________|____________|
Prostate | | 3 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 2 |
__________________________________________________________________________|____________|
Testes | | 44 |
Bilateral, Interstitial Cell, Adenoma| | 43 |
Interstitial Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 2 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 7 |
Mediastinal, Leukemia Mononuclear | | 2 |
Mesenteric, Leukemia Mononuclear | | 2 |
Pancreatic, Leukemia Mononuclear | | 2 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Leukemia Mononuclear | | 22 |
Osteosarcoma, Metastatic, Bone Marrow| | 1 |
__________________________________________________________________________|____________|
Thymus | | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 46 |
Fibroadenoma | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 05021-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/09/97
Route: DOSED FEED Time: 08:49:39
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Adenoma | | 1 |
Squamous Cell Papilloma | | 2 |
Subcutaneous Tissue, Fibroma | | 3 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Myxoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 3 |
Astrocytoma NOS | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 6 |
Alveolar/Bronchiolar Adenoma | | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Leukemia Mononuclear | | 1 |
Osteosarcoma, Metastatic | | 1 |
Osteosarcoma, Metastatic, Bone Marrow| | 1 |
__________________________________________________________________________|____________|
Nose | | 1 |
Basosquamous Tumor Benign | | 1 |
__________________________________________________________________________|____________|
Trachea | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Leukemia Mononuclear | | 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
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