TDMS Study 05021-03 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
CI PIGMENT RED 23
NTP Experiment-Test: 05021-03 Report: PEIRPT05
Study Type: CHRONIC Date: 09/03/94
Route: DOSED FEED Time: 21:10:50
Facility: Southern Research Institute
Chemical CAS #: 6471-49-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05021-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 23 Date: 09/03/94
Route: DOSED FEED Time: 21:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 1.0% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 18 11 14 8
Dead 3 5 3 2
Survivors
Terminal Sacrifice 29 34 33 40
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (1) (50)
Fibrosarcoma, Metastatic, Uterus 1 (100%)
Liver (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Fibrosarcoma, Metastatic, Uterus 1 (2%)
Mesentery (4) (2) (7) (5)
Carcinoma 1 (20%)
Carcinoma, Metastatic, Ovary 1 (14%)
Fibrosarcoma, Metastatic, Uterus 1 (14%)
Sarcoma 1 (25%) 1 (20%)
Pancreas (50) (50) (50) (50)
Acinar Cell, Adenoma 2 (4%)
Stomach, Forestomach (50) (2) (50)
Leiomyosarcoma 1 (2%)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (1) (50)
Adenoma 2 (4%) 2 (4%)
Carcinoma 1 (100%)
Adrenal Gland, Medulla (49) (1) (1) (50)
Pheochromocytoma Malignant 1 (2%) 1 (100%) 1 (100%)
Pheochromocytoma Benign 1 (2%) 6 (12%)
Page 2
NTP Experiment-Test: 05021-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 23 Date: 09/03/94
Route: DOSED FEED Time: 21:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 1.0% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Bilateral, Pheochromocytoma Benign 3 (6%)
Islets, Pancreatic (50) (49) (49) (50)
Adenoma 2 (4%) 1 (2%) 3 (6%)
Carcinoma 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 29 (58%) 23 (46%) 28 (56%) 18 (36%)
Pars Distalis, Carcinoma 2 (4%)
Thyroid Gland (50) (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%) 1 (2%)
C-Cell, Adenoma 5 (10%) 4 (8%) 4 (8%) 2 (4%)
C-Cell, Carcinoma 1 (2%) 4 (8%) 3 (6%)
Follicular Cell, Adenoma 1 (2%) 3 (6%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Mediastinum, Myxoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (48) (47) (49)
Adenoma 5 (11%) 4 (8%) 3 (6%) 2 (4%)
Carcinoma 3 (6%) 1 (2%)
Ovary (50) (4) (1) (50)
Carcinoma 1 (100%)
Granulosa Cell Tumor NOS 1 (25%)
Granulosa Cell Tumor Benign 1 (2%)
Thecoma NOS 2 (50%)
Uterus (50) (50) (50) (50)
Carcinoma, Metastatic, Ovary 1 (2%)
Fibrosarcoma 1 (2%)
Leiomyoma 1 (2%)
Cervix, Sarcoma Stromal 1 (2%)
Cervix, Endometrium, Polyp Stromal 1 (2%)
Endometrium, Polyp Stromal 7 (14%) 4 (8%) 7 (14%) 13 (26%)
Endometrium, Sarcoma Stromal 1 (2%) 1 (2%) 1 (2%)
Vagina (8) (1) (4)
Fibrosarcoma 1 (13%)
Leiomyosarcoma 1 (13%)
Sarcoma 1 (100%)
Schwannoma Malignant 1 (13%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05021-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 23 Date: 09/03/94
Route: DOSED FEED Time: 21:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 1.0% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (1) (1) (50)
Lymph Node (50) (2) (2) (50)
Lumbar, Carcinoma, Metastatic, Ovary 1 (50%)
Renal, Carcinoma, Metastatic, Ovary 1 (50%)
Lymph Node, Mandibular (50) (1) (50)
Spleen (50) (50) (49) (50)
Fibrosarcoma, Metastatic, Uterus 1 (2%)
Hemangioma 1 (2%)
Thymus (49) (48)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (38) (32) (50)
Adenoma 2 (5%) 2 (6%) 1 (2%)
Carcinoma 1 (2%) 2 (5%)
Fibroadenoma 23 (46%) 24 (63%) 14 (44%) 19 (38%)
Skin (50) (8) (2) (49)
Basal Cell Carcinoma 1 (13%)
Keratoacanthoma 1 (2%) 1 (2%)
Sebaceous Gland, Carcinoma 1 (50%)
Subcutaneous Tissue, Fibroma 1 (13%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Tail, Hemangiosarcoma 1 (13%)
Tail, Squamous Cell Papilloma 2 (25%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (5) (3) (50)
Astrocytoma NOS 1 (20%) 3 (6%)
Glioma NOS 1 (2%) 1 (20%)
Meningioma Malignant 1 (2%)
Oligodendroglioma NOS 1 (2%)
Choroid Plexus, Meningioma Malignant,
Metastatic, Brain 1 (2%)
Meninges, Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05021-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 23 Date: 09/03/94
Route: DOSED FEED Time: 21:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 1.0% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (4) (8) (50)
Alveolar/Bronchiolar Adenoma 1 (25%) 1 (13%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (25%)
Carcinoma, Metastatic, Ovary 1 (13%)
Carcinoma, Metastatic, Skin 1 (13%)
Fibrosarcoma, Metastatic, Uterus 1 (13%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Pinna, Squamous Cell Papilloma 1 (100%)
Zymbal's Gland (2) (1)
Adenoma 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (45) (44) (50)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (2) (50)
Papilloma 1 (50%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 14 (28%) 7 (14%) 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05021-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 23 Date: 09/03/94
Route: DOSED FEED Time: 21:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 1.0% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 48 44 44
Total Primary Neoplasms 110 98 81 90
Total Animals with Benign Neoplasms 43 43 41 41
Total Benign Neoplasms 80 75 67 74
Total Animals with Malignant Neoplasms 22 15 14 10
Total Malignant Neoplasms 28 18 14 13
Total Animals with Metastatic Neoplasms 3 1
Total Metastatic Neoplasm 11 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 2 5 3
Total Uncertain Neoplasms 2 5 3
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05021-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 23 Date: 09/03/94
Route: DOSED FEED Time: 21:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 1.0% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 9
Early Deaths
Moribund 24 14 11 11
Dead 4 6 3 5
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 22 29 36 35
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (1) (50)
Mixed Tumor Malignant, Metastatic, Salivary
Glands 1 (2%)
Intestine Large, Rectum (50) (1) (50)
Intestine Small, Ileum (50) (7) (17) (50)
Intestine Small, Jejunum (50) (1) (5) (50)
Adenocarcinoma 1 (2%)
Carcinoma 1 (20%)
Leiomyoma 1 (2%)
Liver (50) (50) (50) (50)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Adenoma 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Mesentery (11) (5) (7) (11)
Fibrosarcoma 1 (20%)
Fibrous Histiocytoma 1 (9%)
Osteosarcoma, Metastatic 1 (14%)
Sarcoma 1 (14%)
Pancreas (50) (2) (49)
Carcinoma, Metastatic, Stomach 1 (2%)
Fibrous Histiocytoma 1 (2%)
Acinar Cell, Adenoma 2 (4%) 1 (50%) 1 (2%)
Salivary Glands (49) (1) (50)
Mixed Tumor Malignant 1 (2%)
Stomach, Forestomach (50) (1) (50)
Carcinoma, Metastatic, Stomach 1 (2%)
Stomach, Glandular (50) (1) (50)
Carcinoma 1 (2%)
Fibrous Histiocytoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05021-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 23 Date: 09/03/94
Route: DOSED FEED Time: 21:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 1.0% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (3) (5) (50)
Fibrosarcoma, Metastatic, Skin 1 (33%)
Mixed Tumor Malignant, Metastatic, Salivary
Glands 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (2) (50)
Adenoma 1 (2%)
Carcinoma 1 (50%)
Adrenal Gland, Medulla (48) (6) (5) (50)
Ganglioneuroma 1 (17%)
Pheochromocytoma Malignant 1 (2%) 1 (20%) 1 (2%)
Pheochromocytoma Complex 1 (20%) 1 (2%)
Pheochromocytoma Benign 18 (38%) 2 (33%) 1 (20%) 15 (30%)
Bilateral, Pheochromocytoma Benign 12 (25%) 2 (33%) 2 (40%) 11 (22%)
Islets, Pancreatic (50) (2) (49)
Adenoma 1 (2%) 3 (6%)
Carcinoma 1 (2%) 2 (100%) 1 (2%)
Parathyroid Gland (49) (1) (1) (49)
Adenoma 2 (4%) 2 (4%)
Mixed Tumor Malignant, Metastatic, Salivary
Glands 1 (2%)
Pituitary Gland (50) (16) (9) (49)
Pars Distalis, Adenoma 12 (24%) 12 (75%) 8 (89%) 8 (16%)
Pars Intermedia, Adenoma 1 (2%)
Pars Nervosa, Adenoma 1 (2%)
Thyroid Gland (50) (50) (49) (50)
Mixed Tumor Malignant, Metastatic, Salivary
Glands 1 (2%)
C-Cell, Adenoma 3 (6%) 6 (12%) 5 (10%) 7 (14%)
C-Cell, Carcinoma 1 (2%) 3 (6%) 1 (2%) 3 (6%)
Follicular Cell, Adenoma 2 (4%) 2 (4%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 2 (4%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4) (1)
Fibroma 2 (50%)
Liposarcoma 1 (25%)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05021-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 23 Date: 09/03/94
Route: DOSED FEED Time: 21:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 1.0% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (2) (48)
Fibrous Histiocytoma 1 (2%)
Preputial Gland (49) (9) (8) (49)
Adenoma 3 (6%) 5 (56%) 8 (100%) 7 (14%)
Carcinoma 2 (4%) 1 (2%)
Prostate (50) (3) (2) (49)
Carcinoma, Metastatic, Stomach 1 (2%)
Fibrous Histiocytoma 1 (2%)
Seminal Vesicle (50) (2) (49)
Carcinoma, Metastatic, Stomach 1 (2%)
Fibrous Histiocytoma 1 (2%)
Testes (50) (44) (44) (49)
Bilateral, Interstitial Cell, Adenoma 42 (84%) 43 (98%) 41 (93%) 44 (90%)
Interstitial Cell, Adenoma 6 (12%) 1 (2%) 3 (7%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (5)
Bone Marrow (50) (2) (50)
Fibrous Histiocytoma 1 (2%)
Sarcoma 1 (50%)
Lymph Node (49) (7) (9) (48)
Bronchial, Carcinoma, Metastatic, Stomach 1 (2%)
Iliac, Fibrous Histiocytoma 1 (2%)
Mesenteric, Carcinoma, Metastatic, Stomach 1 (2%)
Mesenteric, Fibrous Histiocytoma 1 (2%)
Pancreatic, Carcinoma, Metastatic, Islets,
Pancreatic 1 (2%)
Renal, Fibrous Histiocytoma 1 (2%)
Lymph Node, Mandibular (49) (2) (3) (48)
Spleen (50) (50) (48) (50)
Fibrous Histiocytoma 1 (2%) 1 (2%)
Hemangioma 1 (2%)
Osteosarcoma, Metastatic, Bone Marrow 1 (2%)
Thymus (49) (1) (46)
Carcinoma, Metastatic, Stomach 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (100%)
Fibrous Histiocytoma 1 (2%)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05021-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 23 Date: 09/03/94
Route: DOSED FEED Time: 21:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 1.0% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (46) (44) (43)
Fibroadenoma 2 (4%) 2 (4%) 2 (5%) 3 (7%)
Fibroma 2 (5%)
Skin (50) (14) (13) (50)
Adenoma 1 (7%)
Basal Cell Adenoma 1 (2%) 1 (8%)
Basal Cell Carcinoma 2 (4%)
Fibroma 1 (8%)
Keratoacanthoma 1 (2%) 3 (23%) 2 (4%)
Squamous Cell Carcinoma 1 (2%) 1 (8%)
Squamous Cell Papilloma 1 (2%) 2 (14%) 1 (2%)
Face, Keratoacanthoma 1 (2%)
Face, Neurofibroma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 3 (21%) 4 (31%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 2 (14%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Myxoma 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (3) (4) (50)
Astrocytoma NOS 1 (33%) 2 (4%)
Oligodendroglioma NOS 1 (25%)
Meninges, Granular Cell Tumor Malignant 1 (25%)
Meninges, Granular Cell Tumor Benign 1 (2%) 1 (25%)
Meninges, Mixed Tumor Malignant, Metastatic,
Salivary Glands 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (6) (3) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (17%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (33%)
Fibrosarcoma, Metastatic, Skin 1 (17%)
Fibrous Histiocytoma 1 (2%)
Osteosarcoma, Metastatic 1 (17%)
Page 10
NTP Experiment-Test: 05021-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 23 Date: 09/03/94
Route: DOSED FEED Time: 21:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 1.0% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Osteosarcoma, Metastatic, Bone Marrow 1 (17%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (33%)
Nose (50) (1) (1) (49)
Basosquamous Tumor Benign 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Pinna, Neurofibroma 1 (100%)
Pinna, Squamous Cell Papilloma 1 (100%)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (48) (50) (50)
Renal Tubule, Adenoma 2 (4%)
Renal Tubule, Carcinoma 1 (2%) 1 (2%)
Urinary Bladder (50) (1) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 28 (56%) 22 (44%) 10 (20%) 4 (8%)
Lymphoma Malignant Histiocytic 1 (2%)
Mesothelioma Malignant 2 (4%) 3 (6%) 3 (6%)
Mesothelioma NOS 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05021-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CI PIGMENT RED 23 Date: 09/03/94
Route: DOSED FEED Time: 21:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 1.0% 2.5% 5.0%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 48 50
Total Primary Neoplasms 172 121 108 157
Total Animals with Benign Neoplasms 50 48 48 49
Total Benign Neoplasms 117 87 83 123
Total Animals with Malignant Neoplasms 33 30 21 22
Total Malignant Neoplasms 53 33 24 30
Total Animals with Metastatic Neoplasms 2 3 3 2
Total Metastatic Neoplasm 2 6 3 12
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 2 1 1 4
Total Uncertain Neoplasms 6 1 1 13
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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