TDMS Study 05021-03 Pathology Tables
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
Facility: Southern Research Institute
Chemical CAS #: 6471-49-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|
DAY ON TEST | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|
| 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 3 1 1 1 1|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X|
Bile Stasis | 2 |
Clear Cell Focus | X |
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 2 1 |
Hepatodiaphragmatic Nodule | X X X X X |
Hyperplasia | 2 1 |
Hypertrophy, Focal | 2 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Inflammation, Granulomatous | 1 2 1 2 3 |
Necrosis | |
Vacuolization Cytoplasmic | 3 3 1|
Bile Duct, Hyperplasia | 1|
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 2 1 1 |
Autolysis | 3 |
Inflammation, Chronic | |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|
DAY ON TEST | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|
| 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 |
Inflammation, Acute | |
Inflammation, Chronic | 3 1 3 |
Mineralization | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Mineralization | 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 2 1 2 2 1 1 1 2 2 1 1 2 1 1 1 1 3 2|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Ectasia | |
Hyperplasia | 1 1 1 1 1 1|
Hypertrophy | 1 1 1 1 |
Vacuolization Cytoplasmic | 2 2 2 1 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 1 3 1 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 3 3 1 1 2 1 1 3 2 1 |
Pars Distalis, Ectasia | 2 3 3 |
Pars Distalis, Hyperplasia | 2 2 2 1 |
Pars Distalis, Hypertrophy | 1 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 1 2 3 1 1 2 3 1 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|
DAY ON TEST | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|
| 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 3 2 3|
Inflammation, Acute | 1 1 1 |
Inflammation, Chronic | 1 2 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 3 |
Inflammation, Acute | 1 |
Necrosis | 4 |
Cervix, Inflammation, Acute | 2 |
Endometrium, Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Vagina | + + + + + |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypoplasia | 2 2 |
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Congestion | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Ectasia | 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | 4 4 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Hyperplasia | 1 2 1 |
Duct, Ectasia | 2 3 2 1 1 3 3 2 1 2 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 2| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 5| 6| 7| 7|
DAY ON TEST | 0| 1| 7| 2| 2| 4| 7| 4| 7| 2| 9| 2| 2| 2| 2| 9| 9| 5| 2| 2| 9| 8| 8| 2| 2|
| 7| 8| 6| 9| 9| 9| 8| 8| 5| 9| 6| 9| 9| 9| 9| 1| 1| 5| 9| 9| 4| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 2 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2|
Foreign Body | |
Inflammation, Acute | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 |
Alveolus, Mineralization | |
Epithelium, Alveolus, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | X |
Mucosa, Inflammation, Chronic Active | 2 1 |
Nasolacrimal Duct, Cyst | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hydronephrosis | 2 |
Infarct | 3 |
Mineralization | 1 1 1 |
Nephropathy | 1 1 3 2 1 2 1 2 3 3 3 3 1 2 2 1 1 2 1 3 4 1 4 2|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Ureter | |
Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | 2 1 2 1 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X|
Bile Stasis | |
Clear Cell Focus | X |
Congestion | 3 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 1 |
Hypertrophy, Focal | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
Inflammation, Granulomatous | 1 2 1 1 1 2 2 2 2|
Necrosis | 4 |
Vacuolization Cytoplasmic | 2 3 2 2 1 |
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 1 1 1 1 2 1 |
Autolysis | |
Inflammation, Chronic | 1 1 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Acute | 4 |
Inflammation, Chronic | |
Mineralization | 1 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
Mineralization | 4 1 1 1 1 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 1 3 2 1 1 2 2 2 1 1 2 2 1 2 3 2 2 1 2|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Ectasia | 2 1 2 |
Hyperplasia | 1 1 1 2 1 1 1 |
Hypertrophy | 1 1 1 1 1 1|
Vacuolization Cytoplasmic | 3 1 1 2 1 1 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 2 2 2 1 1 2|
Pars Distalis, Ectasia | 1 2 |
Pars Distalis, Hyperplasia | 2 3 1 2 1 |
Pars Distalis, Hypertrophy | 1 1 |
Pars Intermedia, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 1 2 2 1 2 2 2 1 1 2 1 2 1 3 3 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Inflammation, Acute | 3 1 |
Inflammation, Chronic | 1|
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Acute | |
Necrosis | |
Cervix, Inflammation, Acute | |
Endometrium, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Vagina | + + + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypoplasia | |
Myelofibrosis | 1 1 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
Hyperplasia | 1 |
Duct, Ectasia | 2 3 2 1 2 1 2 1 3 1 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 2| 2| 2| 0| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 9| 9| 9| 6| 7| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 1| 3| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 3 1 3 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 1 |
Foreign Body | 2 |
Inflammation, Acute | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 3 |
Alveolus, Mineralization | 1 |
Epithelium, Alveolus, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 |
Fungus | |
Mucosa, Inflammation, Chronic Active | 3 1 |
Nasolacrimal Duct, Cyst | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hydronephrosis | 3 |
Infarct | |
Mineralization | 1 1 1 |
Nephropathy | 4 4 1 1 1 4 2 2 1 3 1 2 3 3 3 3 3 2 3 1 2 3 2 3|
Renal Tubule, Hyperplasia | 2 1 |
__________________________________________________________________________|
Ureter | + |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
Autolysis | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Autolysis | | 1 3.0|
Parasite Metazoan | | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
Parasite Metazoan | | 12 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
Autolysis | | 1 2.0|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
Autolysis | | 1 4.0|
Hyperplasia, Lymphoid | | 10 1.6|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
Autolysis | | 2 3.5|
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus, Multiple | | 34 |
Bile Stasis | | 1 2.0|
Clear Cell Focus | | 2 |
Congestion | | 2 2.5|
Hematopoietic Cell Proliferation | | 3 1.7|
Hepatodiaphragmatic Nodule | | 7 |
Hyperplasia | | 3 1.3|
Hypertrophy, Focal | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Granulomatous | | 14 1.6|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic | | 8 2.1|
Bile Duct, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Atrophy, Focal | | 13 1.2|
Autolysis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 2 1.0|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Duct, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia | | 3 3.0|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | | 3 2.3|
Mineralization | | 1 1.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | | 16 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | | 50 |
Inflammation, Chronic | | 42 1.6|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Cyst | | 1 2.0|
Ectasia | | 3 1.7|
Hyperplasia | | 13 1.1|
Hypertrophy | | 10 1.0|
Vacuolization Cytoplasmic | | 14 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 49 |
Hyperplasia | | 7 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 17 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Ectasia | | 5 2.2|
Pars Distalis, Hyperplasia | | 9 1.8|
Pars Distalis, Hypertrophy | | 3 1.0|
Pars Intermedia, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 33 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 47 |
Hyperplasia | | 5 2.6|
Inflammation, Acute | | 5 1.4|
Inflammation, Chronic | | 3 1.3|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | | 50 |
Follicle, Cyst | | 2 1.0|
__________________________________________________________________________|____________|
Uterus | | 50 |
Dilatation | | 4 2.5|
Inflammation, Acute | | 1 1.0|
Necrosis | | 1 4.0|
Cervix, Inflammation, Acute | | 1 2.0|
Endometrium, Hyperplasia, Cystic | | 2 1.5|
__________________________________________________________________________|____________|
Vagina | | 8 |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Hyperplasia | | 1 2.0|
Hypoplasia | | 2 2.0|
Myelofibrosis | | 2 1.0|
Myeloid Cell, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mesenteric, Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Congestion | | 4 1.8|
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | | 1 1.0|
Ectasia | | 1 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 4 3.3|
__________________________________________________________________________|____________|
Thymus | | 49 |
Cyst | | 3 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Galactocele | | 1 |
Hyperplasia | | 4 1.3|
Duct, Ectasia | | 30 1.9|
__________________________________________________________________________|____________|
Skin | | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Osteopetrosis | | 3 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 13 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 3 2.0|
Foreign Body | | 1 2.0|
Inflammation, Acute | | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 4 2.0|
Alveolus, Mineralization | | 1 1.0|
Epithelium, Alveolus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 1 3.0|
Fungus | | 1 |
Mucosa, Inflammation, Chronic Active | | 4 1.8|
Nasolacrimal Duct, Cyst | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Chronic | | 5 1.2|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Autolysis | | 1 3.0|
Hydronephrosis | | 2 2.5|
Infarct | | 1 3.0|
Mineralization | | 6 1.0|
Nephropathy | | 48 2.2|
Renal Tubule, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Ureter | | 1 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 1 2 1 2 2 2 2 3 2 2 2 2 2|
Pigmentation | 1 2 1 1 1 1 2 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 1 2 |
Necrosis, Focal | |
Pigmentation | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X |
Hyperplasia | |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous | 1 2 1 1 1 |
Necrosis | 1 |
Vacuolization Cytoplasmic | 3 1|
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 1 1 1 2 1 1|
Autolysis | |
Inflammation, Acute | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
Mineralization | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Mineralization | 2 1 1 1 2 1 3 |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia, Focal | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1 3 2 3 1 2 2 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 |
Ectasia | |
Hyperplasia | 1 2 1 2 1 1 2 1 1 |
Hypertrophy | 1 1 2 1 |
Vacuolization Cytoplasmic | 2 3 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Autolysis | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 2 2 3 1 1 1 1 1 1 2 1|
Pars Distalis, Ectasia | 3 2 1 |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 1 1 2 1 2 1 |
Pars Distalis, Hypertrophy | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 3 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 |
Inflammation, Acute | 1 2 1|
Inflammation, Chronic | 1 2 1 1 |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 1 2 2 |
__________________________________________________________________________|
Vagina | + + + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Myeloid Cell, Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | 2 |
Mediastinal, Congestion | 2 |
Mesenteric, Congestion | 1 |
Mesenteric, Pigmentation | 2 2 3 1 2 1 |
Pancreatic, Ectasia | 2 |
Pancreatic, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
Hematopoietic Cell Proliferation | |
Granulocytic | 3 2 |
__________________________________________________________________________|
Thymus | I + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Medulla, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 1|
Duct, Ectasia | 2 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 5| 2| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
Foreign Body | 2 |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 2 3 |
Meninges, Infiltration Cellular, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 |
Epithelium, Alveolus, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | |
Mucosa, Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Infarct | |
Mineralization | 1 1 1 1 1 |
Nephropathy | 1 1 1 1 3 1 1 1 3 2 1 1 2 3 2 2 3 2 3 2 2 2 1|
Cortex, Cyst | |
Renal Tubule, Hyperplasia | 3 1 |
Renal Tubule, Epithelium, | |
Degeneration | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 3 |
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
Hyperplasia, Lymphoid | 3 2 1 1 1 2 2 2 3 3 3 2 2|
Pigmentation | 1 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 3 |
Hyperplasia, Lymphoid | 2 2 |
Necrosis, Focal | 3 |
Pigmentation | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Hematopoietic Cell Proliferation | 4 |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia | 2 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Granulomatous | 2 1 2 1 1 1 1 1 2 1 2 |
Necrosis | 3 |
Vacuolization Cytoplasmic | 1 1 1 |
Bile Duct, Hyperplasia | 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 1 1 1 1 2 1 2|
Autolysis | 2 4 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Chronic | 2 |
Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Mineralization | 1 2 2 1 2 2 1 1 1 1 2 1 1 2 1 |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 2 2 1 2 1 1 1 1 1 1 2 1 1 1 1 1 2 1 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 1 1 1 2 2|
Hyperplasia | 1 1 1 1 1 2 3 1 1 |
Hypertrophy | 1 1 1 2 2 2 |
Vacuolization Cytoplasmic | 2 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hyperplasia | 2 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 2 |
Autolysis | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 1 2 1 3 1 1 1 1 1 1|
Pars Distalis, Ectasia | 1 1 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 1 1 2 3|
Pars Distalis, Hypertrophy | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 3 1 1 1 2 3 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 |
Duct, Cyst | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Vagina | + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | |
Mediastinal, Congestion | |
Mesenteric, Congestion | |
Mesenteric, Pigmentation | 2 2 2 |
Pancreatic, Ectasia | |
Pancreatic, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hyperplasia, Re Cell | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hematopoietic Cell Proliferation | |
Granulocytic | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | 1 |
Medulla, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Duct, Ectasia | 2 2 2 1 2 1 1 3 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 1 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 5| 4| 1| 1| 1| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 0| 2| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
Foreign Body | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 2 |
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 |
Epithelium, Alveolus, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 |
Fungus | X X |
Mucosa, Inflammation, Chronic Active | 1 1 2 3 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
Infarct | 2 |
Mineralization | 1 1 |
Nephropathy | 1 2 2 3 2 1 3 2 1 2 1 1 3 1 2 2 3 2 3 1 2 2 3|
Cortex, Cyst | 1 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Epithelium, | |
Degeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
Autolysis | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Autolysis | | 2 2.5|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
Autolysis | | 2 2.5|
Parasite Metazoan | | 8 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
Autolysis | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
Autolysis | | 2 3.0|
Hyperplasia, Lymphoid | | 26 2.0|
Pigmentation | | 10 1.3|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
Autolysis | | 2 3.5|
Hyperplasia, Lymphoid | | 4 1.8|
Necrosis, Focal | | 1 3.0|
Pigmentation | | 2 1.5|
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus, Multiple | | 43 |
Clear Cell Focus | | 1 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hepatodiaphragmatic Nodule | | 9 |
Hyperplasia | | 2 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Granulomatous | | 16 1.3|
Necrosis | | 2 2.0|
Vacuolization Cytoplasmic | | 5 1.4|
Bile Duct, Hyperplasia | | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Necrosis, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Atrophy, Focal | | 19 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Autolysis | | 2 3.0|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Autolysis | | 1 3.0|
Mineralization | | 22 1.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Inflammation, Chronic | | 46 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Congestion | | 3 2.0|
Ectasia | | 5 1.4|
Hyperplasia | | 18 1.3|
Hypertrophy | | 10 1.4|
Vacuolization Cytoplasmic | | 7 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Angiectasis | | 1 1.0|
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Atypia Cellular | | 2 2.0|
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 22 1.4|
Pars Distalis, Ectasia | | 5 1.6|
Pars Distalis, Hemorrhage | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia | | 11 1.5|
Pars Distalis, Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 24 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 49 |
Hyperplasia | | 1 2.0|
Inflammation, Acute | | 3 1.3|
Inflammation, Chronic | | 7 1.1|
Duct, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | | 50 |
Follicle, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | | 50 |
Dilatation | | 4 2.0|
__________________________________________________________________________|____________|
Vagina | | 4 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Autolysis | | 1 4.0|
Myeloid Cell, Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Inguinal, Hyperplasia | | 1 2.0|
Mediastinal, Congestion | | 1 2.0|
Mesenteric, Congestion | | 1 1.0|
Mesenteric, Pigmentation | | 9 1.9|
Pancreatic, Ectasia | | 1 2.0|
Pancreatic, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 50 |
Congestion | | 2 1.5|
Hyperplasia, Re Cell | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Atrophy, Focal | | 1 2.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | |
Granulocytic | | 3 2.7|
__________________________________________________________________________|____________|
Thymus | | 48 |
Cyst | | 1 1.0|
Medulla, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Hyperplasia | | 4 1.3|
Duct, Ectasia | | 18 1.5|
__________________________________________________________________________|____________|
Skin | | 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Osteopetrosis | | 7 1.7|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Foreign Body | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 7 2.3|
Meninges, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Hyperplasia, Lymphoid | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 6 1.0|
Epithelium, Alveolus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 3 2.0|
Fungus | | 2 |
Mucosa, Inflammation, Chronic Active | | 5 1.6|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 9| 9| 9| 9| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Autolysis | | 2 3.5|
Infarct | | 1 2.0|
Mineralization | | 7 1.0|
Nephropathy | | 46 1.9|
Cortex, Cyst | | 1 1.0|
Renal Tubule, Hyperplasia | | 2 2.0|
Renal Tubule, Epithelium, | | |
Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 5| 5| 6| 6| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 7| 3| 3| 6| 9| 6| 8| 3| 5| 0| 3| 3| 3| 9| 5| 3| 3| 3| 8| 3| 3| 3| 3|
| 2| 5| 2| 2| 2| 4| 5| 2| 8| 2| 7| 1| 2| 2| 2| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 3 2 4 2 2 3 3 3|
Pigmentation | 1 1 1|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
Hyperplasia, Lymphoid | 1 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X|
Ectasia | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | 1 1 |
Inflammation, Granulomatous | 3 |
Leukocytosis | 2 |
Vacuolization Cytoplasmic | 4 2 1 1|
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis, Focal | 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 1 1 1 1 |
Atrophy | |
Ectopic Liver | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Ectasia | |
Pars Distalis, Hyperplasia | 2 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 2 1 1 1 2 2|
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 5| 5| 6| 6| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 7| 3| 3| 6| 9| 6| 8| 3| 5| 0| 3| 3| 3| 9| 5| 3| 3| 3| 8| 3| 3| 3| 3|
| 2| 5| 2| 2| 2| 4| 5| 2| 8| 2| 7| 1| 2| 2| 2| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 |
Inflammation, Acute | 2 2 2 |
Inflammation, Chronic | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Ovary | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Dilatation | 3 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Polychromasia | 3 |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 3 |
Hematopoietic Cell Proliferation | |
Granulocytic | 3 |
Hematopoietic Cell Proliferation | |
Erythrocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 |
Duct, Ectasia | 1 3 3 2 2 1 3 2 2 3 2|
__________________________________________________________________________|
Skin | + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + +|
Osteopetrosis | 2 2 2 2 1|
__________________________________________________________________________|
Skeletal Muscle | + |
Cyst | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
Compression | 3 2 |
Gliosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 7| 3| 5| 7| 7| 5| 5| 6| 6| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 7| 3| 3| 6| 9| 6| 8| 3| 5| 0| 3| 3| 3| 9| 5| 3| 3| 3| 8| 3| 3| 3| 3|
| 2| 5| 2| 2| 2| 4| 5| 2| 8| 2| 7| 1| 2| 2| 2| 1| 1| 2| 2| 2| 8| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + |
Congestion | 4 |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hydronephrosis | 3 |
Nephropathy | 2 1 3 2 1 1 3 3 3 2 3 2 3 3 2 1 2 2 3 1 2|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 4| 1| 3| 3| 3|
| 1| 5| 5| 5| 5| 5| 2| 2| 5| 5| 5| 5| 5| 5| 5| 8| 3| 5| 5| 5| 6| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 3 3 2 2 2 3 2 3 2 2 3 3|
Pigmentation | 1 1 3|
__________________________________________________________________________|
Intestine Small, Jejunum | +|
Hyperplasia, Lymphoid | 1|
Pigmentation | 2|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X X X|
Ectasia | 1 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | |
Inflammation, Granulomatous | 2 1 2 2 1 1 1 1 1 1 |
Leukocytosis | |
Vacuolization Cytoplasmic | 3 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 1 3 |
Atrophy | 1 1 |
Ectopic Liver | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 2 2 1 2 |
Pars Distalis, Ectasia | 2 1 2 |
Pars Distalis, Hyperplasia | 3 2 2 1 1 1 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 3 1 2 1 2 1 2 2 4 1 4 3 1 4 1 1 |
Follicle, Cyst | 2|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 4| 1| 3| 3| 3|
| 1| 5| 5| 5| 5| 5| 2| 2| 5| 5| 5| 5| 5| 5| 5| 8| 3| 5| 5| 5| 6| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + M + M + +|
Atrophy | 2 |
Hyperplasia | |
Inflammation, Acute | 3 2 |
Inflammation, Chronic | 1 1 |
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Dilatation | 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Polychromasia | |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hematopoietic Cell Proliferation | |
Erythrocytic | 3 2 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
Duct, Ectasia | 2 3 3 3 3 2 3 3 3 1 3 |
__________________________________________________________________________|
Skin | + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + |
Osteopetrosis | 3 2 4 4 3 |
__________________________________________________________________________|
Skeletal Muscle | |
Cyst | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Compression | 2 |
Gliosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 3| 3| 3| 4| 1| 3| 3| 3|
| 1| 5| 5| 5| 5| 5| 2| 2| 5| 5| 5| 5| 5| 5| 5| 8| 3| 5| 5| 5| 6| 2| 2| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + |
Congestion | 2 |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 1 2 |
Hydronephrosis | |
Nephropathy | 3 2 3 2 2 3 2 3 2 3 2 3 2 1 2 2 2 1 2 2 3 1|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 9| 9| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 1 |
__________________________________________________________________________|____________|
Intestine Small | | 25 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 24 |
Hyperplasia, Lymphoid | | 24 2.5|
Pigmentation | | 6 1.3|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 4 |
Hyperplasia, Lymphoid | | 3 1.3|
Pigmentation | | 2 1.5|
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus, Multiple | | 37 |
Ectasia | | 1 1.0|
Hepatodiaphragmatic Nodule | | 8 |
Inflammation, Chronic | | 2 1.0|
Inflammation, Granulomatous | | 11 1.5|
Leukocytosis | | 1 2.0|
Vacuolization Cytoplasmic | | 6 2.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Fat, Necrosis, Focal | | 5 2.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Atrophy, Focal | | 11 1.3|
Atrophy | | 2 1.0|
Ectopic Liver | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Atypia Cellular | | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Cyst | | 7 1.7|
Pars Distalis, Ectasia | | 3 1.7|
Pars Distalis, Hyperplasia | | 11 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 32 1.6|
Follicle, Cyst | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 9| 9| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 47 |
Atrophy | | 1 2.0|
Hyperplasia | | 1 2.0|
Inflammation, Acute | | 5 2.2|
Inflammation, Chronic | | 2 1.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | | 1 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Cyst | | 1 4.0|
Dilatation | | 2 2.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Polychromasia | | 1 3.0|
__________________________________________________________________________|____________|
Bone Marrow | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 1 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 49 |
Hematopoietic Cell Proliferation | | 2 3.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 3.0|
Hematopoietic Cell Proliferation | | |
Erythrocytic | | 3 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 32 |
Hyperplasia | | 5 1.8|
Duct, Ectasia | | 22 2.4|
__________________________________________________________________________|____________|
Skin | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 9| 9| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | | 10 |
Osteopetrosis | | 10 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 3 |
Compression | | 3 2.3|
Gliosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 8 |
Congestion | | 2 3.0|
Hemorrhage | | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 3.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 44 |
Congestion | | 3 1.7|
Hydronephrosis | | 1 3.0|
Nephropathy | | 43 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 3| 0| 2| 3| 3| 3| 9| 5| 2| 3| 3| 4| 1| 7| 3| 3| 0| 2| 2| 3| 3|
| 3| 9| 5| 5| 5| 7| 9| 5| 5| 5| 2| 1| 9| 5| 5| 2| 2| 3| 6| 6| 3| 7| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
Hyperplasia, Lymphoid | 3 1 2 2 3 1 2 1 |
Inflammation | |
Pigmentation | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
Hyperplasia, Lymphoid | 2 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | 2 2 |
Inflammation, Acute | 2 |
Inflammation, Granulomatous | 2 1 1 1 1 2|
Leukocytosis | 2 |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Hyperplasia | 1 1 1 1 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 3 1 |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
Hyperplasia | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + |
Necrosis | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 3| 0| 2| 3| 3| 3| 9| 5| 2| 3| 3| 4| 1| 7| 3| 3| 0| 2| 2| 3| 3|
| 3| 9| 5| 5| 5| 7| 9| 5| 5| 5| 2| 1| 9| 5| 5| 2| 2| 3| 6| 6| 3| 7| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | 2 1 2 4 2 1 2 3 |
Pars Distalis, Ectasia | 3 2 2 |
Pars Distalis, Hyperplasia | 1 1 2 2 1 2 1 |
Pars Distalis, Hypertrophy | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 4 1 1 2 3 1 1 2 3 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia, Cystic | 2|
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + I +|
Hyperplasia | 4 4 |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + |
Follicle, Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Dilatation | 2 |
Hemorrhage | 3 |
Cervix, Cyst | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
Hypoplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 3 1 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 2 |
Hemorrhage, Focal | |
Infarct | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 3| 3| 3| 0| 2| 3| 3| 3| 9| 5| 2| 3| 3| 4| 1| 7| 3| 3| 0| 2| 2| 3| 3|
| 3| 9| 5| 5| 5| 7| 9| 5| 5| 5| 2| 1| 9| 5| 5| 2| 2| 3| 6| 6| 3| 7| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Duct, Ectasia | 1 1 2 1 2 2 1 |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + |
Acanthosis | |
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
Osteopetrosis | 2 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 2 4 |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Nephropathy | 2 2 2 2 1 1 3 1 1 2 2 2 2 2 3 3 2 3 2 1 1 3|
Renal Tubule, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + |
Hyperplasia | |
Inflammation, Chronic Active | 4 |
Metaplasia, Squamous | 3 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 7| 8| 3| 3| 3| 1| 7| 3| 3| 3|
| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 6| 3| 6| 6| 6| 6| 4| 3| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
Hyperplasia, Lymphoid | 2 2 2 1 2 2 |
Inflammation | 3 |
Pigmentation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
Hyperplasia, Lymphoid | 1 2 1 |
Pigmentation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Hepatodiaphragmatic Nodule | X X X X X |
Hyperplasia | 1 1 |
Inflammation, Acute | |
Inflammation, Granulomatous | 2 2 2 3 2 1 2 |
Leukocytosis | 2 |
Vacuolization Cytoplasmic | 2 3 3 |
Bile Duct, Hyperplasia | 1 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 1 1 1 |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
Hyperplasia | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | |
Necrosis | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 7| 8| 3| 3| 3| 1| 7| 3| 3| 3|
| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 6| 3| 6| 6| 6| 6| 4| 3| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | 2 3 1 2 2 2 1 |
Pars Distalis, Ectasia | 4 3 2 2 4|
Pars Distalis, Hyperplasia | 1 2 2 |
Pars Distalis, Hypertrophy | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 1 1 4 1 3 1 1 4 1 1 1 1 1 1 |
Follicle, Dilatation | 1 |
Follicular Cell, Hyperplasia, Cystic | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + |
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Dilatation | 3 3 |
Hemorrhage | |
Cervix, Cyst | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
Hypoplasia | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hematopoietic Cell Proliferation | |
Erythrocytic | |
Hemorrhage, Focal | 3 |
Infarct | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 4 1 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 7| 8| 3| 3| 3| 1| 7| 3| 3| 3|
| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 7| 6| 6| 6| 3| 6| 6| 6| 6| 4| 3| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Duct, Ectasia | 2 2 2 3 3 2 2 2 2 3 2 2 2 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Skin | + + |
Acanthosis | 3 2 |
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
Osteopetrosis | 3 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
Compression | 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Nephropathy | 3 4 2 3 2 2 1 2 1 2 1 1 2 3 4 3 2 2 3 1 2 2|
Renal Tubule, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + |
Hyperplasia | 4 |
Inflammation, Chronic Active | |
Metaplasia, Squamous | |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Small | | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 15 |
Hyperplasia, Lymphoid | | 14 1.9|
Inflammation | | 1 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 6 |
Hyperplasia, Lymphoid | | 5 1.4|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus, Multiple | | 35 |
Clear Cell Focus | | 3 |
Hepatodiaphragmatic Nodule | | 8 |
Hyperplasia | | 4 1.5|
Inflammation, Acute | | 1 2.0|
Inflammation, Granulomatous | | 13 1.7|
Leukocytosis | | 2 2.0|
Vacuolization Cytoplasmic | | 4 2.8|
Bile Duct, Hyperplasia | | 6 1.0|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Atrophy, Focal | | 8 1.4|
__________________________________________________________________________|____________|
Stomach | | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 2 |
Hyperplasia | | 1 3.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 1 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Atrophy | | 1 4.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 1 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Cyst | | 15 2.0|
Pars Distalis, Ectasia | | 8 2.8|
Pars Distalis, Hyperplasia | | 10 1.5|
Pars Distalis, Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 26 1.8|
Follicle, Dilatation | | 1 1.0|
Follicular Cell, Hyperplasia, Cystic | | 1 2.0|
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 48 |
Hyperplasia | | 3 3.7|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 3 1.0|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | | 4 |
Follicle, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | | 50 |
Cyst | | 2 3.5|
Dilatation | | 3 2.7|
Hemorrhage | | 1 3.0|
Cervix, Cyst | | 2 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 1 |
Hypoplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hematopoietic Cell Proliferation | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Granulocytic | | 3 2.0|
Hematopoietic Cell Proliferation | | |
Erythrocytic | | 1 2.0|
Hemorrhage, Focal | | 1 3.0|
Infarct | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 38 |
Hyperplasia | | 4 2.0|
Inflammation, Acute | | 1 3.0|
Duct, Ectasia | | 20 2.0|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | | 8 |
Acanthosis | | 2 2.5|
Hyperkeratosis | | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 5 |
Osteopetrosis | | 5 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 5 |
Compression | | 3 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 2 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 45 |
Inflammation, Chronic | | 1 2.0|
Nephropathy | | 44 2.1|
Renal Tubule, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 2 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 8| 8| 8| 8| 9| 8| 8| 8| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 4.0|
Metaplasia, Squamous | | 1 3.0|
Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|
| 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Edema | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 1 |
Mineralization | 2 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Mineralization | 2 |
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
Hyperplasia, Lymphoid | 1 3 2 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | 2 2 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X |
Clear Cell Focus | X |
Cytoplasmic Alteration, Focal | 2 |
Ectasia | 3 2 |
Eosinophilic Focus | |
Eosinophilic Focus, Multiple | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | |
Inflammation, Granulomatous | |
Leukocytosis | |
Necrosis | |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Autolysis | |
Inflammation, Acute | |
Fat, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|
| 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 1 2 3 2 1 1 |
Autolysis | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
Hyperplasia | 1 |
Mineralization | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
Mineralization | 3 |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 3 2 3 1 2 1 1 1 2 1 2 2 1 1 2 1 2 2|
Mineralization | 4 |
Atrium Left, Thrombosis | 3 |
Valve, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Hyperplasia | 1 1 1 1 1 1 2 1|
Hypertrophy | |
Vacuolization Cytoplasmic | 2 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 1 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 3 |
Pars Distalis, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|
| 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 1 2 1 1 2 |
Pars Distalis, Hypertrophy | 1 1 1 1 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 3 1 2 1 1 2 1 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia, Cystic | 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 3 1 4 |
Inflammation, Chronic | 1 2 2 2 1 2 1 1 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Acute | 4 1 2 1 1 1 1 |
Inflammation, Chronic | 1 2 1 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | 3 |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Anemia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Autolysis | |
Mesenteric, Hemorrhage | 2 |
Mesenteric, Lymphocyte, Depletion | |
Cellular | 3 |
Pancreatic, Congestion | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|
| 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Ectasia | 2 |
Pancreatic, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | |
Hyperplasia | |
Hyperplasia, Re Cell | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis | 2 2 1 |
Hematopoietic Cell Proliferation | |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Hyperplasia | 2 2 |
Inflammation, Chronic | 3 |
Duct, Ectasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic Active | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 |
Hydrocephalus | |
Inflammation, Acute, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 2| 2| 2| 8| 1| 1| 7| 0| 8| 9| 0| 7| 2| 8| 0| 2| 2| 2| 0| 1| 0| 2| 2|
| 2| 0| 9| 9| 9| 5| 2| 2| 6| 0| 2| 7| 5| 6| 9| 1| 7| 9| 9| 9| 2| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 2|
Mineralization | 2 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Fungus | X X X X |
Inflammation, Chronic | 1|
Mucosa, Inflammation, Chronic Active | 3 2 3 3 2 3 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 |
Respiratory Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | |
Nephropathy | 1 2 3 2 3 2 3 2 2 3 2 2 4 3 3 2 3 2 3 1 2 2 3 3|
Renal Tubule, Degeneration | 3 |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Epithelium, | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|
| 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Edema | |
Inflammation, Acute | 2 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia, Lymphoid | 1 |
Mineralization | |
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Mineralization | |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | 3 2 2 1 2 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X |
Clear Cell Focus | X |
Cytoplasmic Alteration, Focal | |
Ectasia | |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | X |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2|
Inflammation, Granulomatous | 2 |
Leukocytosis | 4 |
Necrosis | 4 |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 2 1 1 1 1 1 1 4 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Autolysis | 4 |
Inflammation, Acute | 3 |
Fat, Necrosis | 2 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|
| 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 2 1 2 1 1 1 2 1 2 2 1 1 2|
Autolysis | 3 3 |
Artery, Inflammation, Chronic | 3 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +|
Atrophy | 1 1 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia | |
Mineralization | 2 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Mineralization | 2 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 3 2 1 2 3 1 3 2 1 2 2 1 2 2 1 2 2 1 2 2 1 1|
Mineralization | 1 |
Atrium Left, Thrombosis | |
Valve, Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + M M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + M M + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 1 1 1 |
Hypertrophy | 2 2 1 1 |
Vacuolization Cytoplasmic | 1 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M M + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Bilateral, Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 1 1 1 2|
Pars Distalis, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|
| 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 2 1 1 3 1 1 2 2 2 |
Pars Distalis, Hypertrophy | 2 1 1 2 1 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 3 2 1 3 1 1 |
Follicle, Dilatation | 1 2 |
Follicular Cell, Hyperplasia, Cystic | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 2 1 1 |
Inflammation, Chronic | 1 1 1 1 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | 3 |
Inflammation, Chronic | 2 1 2 1 1 1 3 3 1 2 1 2 1 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hemorrhage | |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
Anemia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 3 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +|
Mesenteric, Autolysis | 3 |
Mesenteric, Hemorrhage | |
Mesenteric, Lymphocyte, Depletion | |
Cellular | |
Pancreatic, Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|
| 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Ectasia | 3 |
Pancreatic, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Ectasia | 2 |
Hemorrhage | 2 |
Hyperplasia | 1 |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Angiectasis | |
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
Hyperplasia | 1 1 |
Inflammation, Chronic | |
Duct, Ectasia | 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Inflammation, Chronic Active | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hydrocephalus | 1 |
Inflammation, Acute, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7|
DAY ON TEST | 3| 8| 2| 2| 2| 1| 4| 5| 3| 3| 6| 3| 4| 3| 3| 4| 3| 3| 3| 3| 3| 1| 6| 2| 3|
| 5| 2| 9| 9| 9| 2| 0| 5| 0| 0| 3| 1| 0| 0| 0| 8| 1| 1| 1| 1| 0| 3| 4| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Mineralization | |
Thrombosis | 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 1 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 2 |
Fungus | |
Inflammation, Chronic | 1 2 1 |
Mucosa, Inflammation, Chronic Active | 3 3 4 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 3 3 |
Respiratory Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | 3 |
Nephropathy | 2 1 3 3 3 2 2 2 3 3 2 3 3 3 3 2 3 4 4 3 3 2 2 4 3|
Renal Tubule, Degeneration | |
Renal Tubule, Hyperplasia | 1 3 |
Renal Tubule, Epithelium, | |
Hypertrophy, Focal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
Autolysis | | 1 3.0|
Edema | | 1 2.0|
Inflammation, Acute | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Autolysis | | 1 3.0|
Hyperplasia, Lymphoid | | 2 1.0|
Mineralization | | 1 2.0|
Parasite Metazoan | | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
Autolysis | | 1 3.0|
Mineralization | | 1 2.0|
Parasite Metazoan | | 7 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
Autolysis | | 2 2.5|
Hyperplasia, Lymphoid | | 11 1.9|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
Autolysis | | 2 4.0|
Hyperplasia, Lymphoid | | 5 2.0|
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus, Multiple | | 10 |
Clear Cell Focus | | 2 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Ectasia | | 2 2.5|
Eosinophilic Focus | | 1 |
Eosinophilic Focus, Multiple | | 1 |
Hepatodiaphragmatic Nodule | | 6 |
Hyperplasia, Focal | | 3 2.0|
Hypertrophy, Focal | | 1 2.0|
Inflammation, Granulomatous | | 1 2.0|
Leukocytosis | | 1 4.0|
Necrosis | | 1 4.0|
Thrombosis | | 2 2.0|
Bile Duct, Hyperplasia | | 10 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Centrilobular, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | | 11 |
Autolysis | | 1 4.0|
Inflammation, Acute | | 1 3.0|
Fat, Necrosis | | 5 2.4|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Atrophy, Focal | | 23 1.6|
Autolysis | | 2 3.0|
Artery, Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
Atrophy | | 2 1.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperkeratosis | | 1 1.0|
Hyperplasia | | 1 1.0|
Mineralization | | 1 2.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Autolysis | | 1 1.0|
Mineralization | | 3 2.3|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | | 50 |
Inflammation, Chronic | | 43 1.7|
Mineralization | | 2 2.5|
Atrium Left, Thrombosis | | 1 3.0|
Valve, Inflammation, Acute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 48 |
Cyst | | 1 1.0|
Hyperplasia | | 12 1.1|
Hypertrophy | | 4 1.5|
Vacuolization Cytoplasmic | | 7 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 48 |
Hyperplasia | | 6 1.3|
Bilateral, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 50 |
Pars Distalis, Cyst | | 7 1.6|
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia | | 14 1.6|
Pars Distalis, Hypertrophy | | 9 1.2|
Pars Intermedia, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 17 1.8|
Follicle, Dilatation | | 2 1.5|
Follicular Cell, Hyperplasia, Cystic | | 1 1.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 4 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 50 |
Granuloma Sperm | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | | 49 |
Inflammation, Acute | | 9 1.7|
Inflammation, Chronic | | 14 1.3|
__________________________________________________________________________|____________|
Prostate | | 50 |
Hyperplasia | | 1 1.0|
Inflammation, Acute | | 8 1.8|
Inflammation, Chronic | | 20 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | | 50 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 50 |
Atrophy | | 1 3.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 5 |
Anemia | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Autolysis | | 2 3.5|
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 49 |
Mesenteric, Autolysis | | 1 3.0|
Mesenteric, Hemorrhage | | 1 2.0|
Mesenteric, Lymphocyte, Depletion | | |
Cellular | | 1 3.0|
Pancreatic, Congestion | | 1 2.0|
Pancreatic, Ectasia | | 2 2.5|
Pancreatic, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Ectasia | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia | | 1 1.0|
Hyperplasia, Re Cell | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Congestion | | 4 2.3|
Fibrosis | | 4 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | | 49 |
Angiectasis | | 1 2.0|
Congestion | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
Galactocele | | 1 3.0|
Hyperplasia | | 4 1.5|
Inflammation, Chronic | | 1 3.0|
Duct, Ectasia | | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | | 50 |
Congestion | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Fibrous Osteodystrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 2 1.5|
Hydrocephalus | | 1 1.0|
Inflammation, Acute, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 1 3.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 2 2.0|
Mineralization | | 1 2.0|
Thrombosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 5 2.2|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Foreign Body | | 5 2.0|
Fungus | | 4 |
Inflammation, Chronic | | 4 1.3|
Mucosa, Inflammation, Chronic Active | | 9 2.9|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 5 2.4|
Respiratory Epithelium, Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Inflammation, Acute, Multifocal | | 1 3.0|
Nephropathy | | 49 2.6|
Renal Tubule, Degeneration | | 1 3.0|
Renal Tubule, Hyperplasia | | 3 1.7|
Renal Tubule, Epithelium, | | |
Hypertrophy, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 4 |
Diverticulum | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | 1 1 |
Hyperplasia, Adenomatous | |
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | 3 3 3 1 1 3 2 2 2 2 |
Pigmentation | 1 1 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 4 |
Hyperplasia, Lymphoid | |
Pigmentation | 1 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Basophilic Focus, Multiple | X X |
Clear Cell Focus | X X |
Congestion | |
Cyst | 2|
Ectasia | 2 |
Eosinophilic Focus | X |
Eosinophilic Focus, Multiple | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2 1 |
Hypertrophy, Focal | 1 2 1 |
Hypertrophy, Multifocal | |
Inflammation, Acute | |
Inflammation, Granulomatous | 1 1 |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Hyperplasia | 1 1 1 |
Centrilobular, Necrosis | 3 |
Centrilobular, Vacuolization | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cytoplasmic | 2 2 |
Hepatocyte, Degeneration, Cystic | 2 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Inflammation, Chronic | 3 |
Artery, Inflammation, Chronic | 2 |
Fat, Necrosis | 2 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + M + + + +|
Atrophy, Diffuse | |
Atrophy, Focal | 2 2 1 1 1 1 2 1 1 1 1 1|
Autolysis | |
Cytoplasmic Alteration | 1 |
Hyperplasia | |
Inflammation, Chronic | |
Artery, Inflammation, Chronic | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Vacuolization Cytoplasmic | 2 |
Acinar Cell, Cytoplasmic Alteration | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 |
Mucosa, Cyst | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 1 1 1 1 2 2 2 1 1 2 2 2 3 2 2 2 2 1 3 2 1 1|
Atrium Left, Thrombosis | 3 4 2 4 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia | 1 1 1 1 1 2 1 1|
Hypertrophy | |
Vacuolization Cytoplasmic | 2 2 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 1 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +|
Autolysis | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 1 1 |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 1 1 1 1 |
Pars Distalis, Hypertrophy | 1 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 2 4 1 1 3 1 1 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia, Cystic | |
Follicular Cell, Hypertrophy | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + M + + + + + + + + M + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 3 1 1 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +|
Cyst | 2 |
Inflammation, Acute | 3 1 1 |
Inflammation, Chronic | 1 2 2 1 2 1 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + M + + + +|
Dilatation | 2 2 |
Epithelium, Degeneration | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + M + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hemorrhage | |
Hypoplasia | 2 3 |
Myelofibrosis | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Re Cell | |
Mediastinal, Hemorrhage | 1 |
Mediastinal, Hyperplasia, Re Cell | 2 |
Mesenteric, Congestion | |
Mesenteric, Hyperplasia, Re Cell | 2 |
Mesenteric, Pigmentation | 2 3 2 2 |
Pancreatic, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Ectasia | 3 |
Hemorrhage | 3 |
Hyperplasia | 1 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Autolysis | 3 |
Congestion | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + I + + I I + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + I + I + M + + + + + + + + + M + + +|
Hyperplasia | 2 2 3 1 2|
Duct, Ectasia | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
Inflammation, Chronic Active | 3 |
Face, Inflammation, Chronic | 3 |
Subcutaneous Tissue, Abscess | |
Tail, Cyst Epithelial Inclusion | |
Tail, Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 3| 0| 0| 0| 0| 0| 0| 0| 0| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Choroid Plexus, Infiltration | |
Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Congestion | |
Hyperplasia, Lymphoid | 1 1 1 1 |
Inflammation, Chronic | 1 2 |
Inflammation, Granulomatous | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Foreign Body | 2 2 2 |
Fungus | X |
Inflammation, Chronic | 1 1 1 |
Mucosa, Inflammation, Chronic Active | 1 2 4 1 4 |
Mucosa, Glands, Exudate | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 1 2 1 1 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Bilateral, Lens, Cataract | 4 |
Bilateral, Retina, Degeneration | 3 |
Cornea, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Congestion | |
Mineralization | 1 |
Nephropathy | 2 3 3 4 4 3 4 3 3 3 2 1 3 3 3 3 3 3 3 4 3 3 3 4|
Cortex, Cyst | 2 |
Renal Tubule, Hyperplasia | 3 1 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|
| 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 2 |
Diverticulum | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Adenomatous | 2 |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 2 |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 2 |
Hyperplasia, Lymphoid | 1 1 2 2 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 2 |
Hyperplasia, Lymphoid | 2 2 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Basophilic Focus, Multiple | X X X X X |
Clear Cell Focus | X X X |
Congestion | 3 |
Cyst | |
Ectasia | |
Eosinophilic Focus | X X X |
Eosinophilic Focus, Multiple | X |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2 1 3 |
Hypertrophy, Focal | 2 |
Hypertrophy, Multifocal | 2 |
Inflammation, Acute | 1 |
Inflammation, Granulomatous | 1 1 |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 |
Centrilobular, Necrosis | 3 |
Centrilobular, Vacuolization | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|
| 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cytoplasmic | |
Hepatocyte, Degeneration, Cystic | 1 2 1 2 1 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic | |
Artery, Inflammation, Chronic | |
Fat, Necrosis | 1 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 4|
Atrophy, Focal | 1 1 1 1 2 2 1 2 2 |
Autolysis | 4 |
Cytoplasmic Alteration | |
Hyperplasia | 2 |
Inflammation, Chronic | 2 |
Artery, Inflammation, Chronic | 3 4 2 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Vacuolization Cytoplasmic | |
Acinar Cell, Cytoplasmic Alteration | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 3 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 1 |
Mucosa, Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 3 2 2 2 3 1 2 2 2 2 1 2 1 2 2 1 1 3 1 1 2 1 1|
Atrium Left, Thrombosis | 2 3 3 4 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | 1 2 1 1 1 1 2 1 2 1|
Hypertrophy | 2 |
Vacuolization Cytoplasmic | 1 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 1 2 1 1 1 1 1 2 |
Bilateral, Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|
| 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 3 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 1 2 2 |
Pars Distalis, Hypertrophy | 1 1 1 1 |
Pars Nervosa, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 3 1 2 1 1 |
Follicle, Dilatation | 1 2 1 2|
Follicular Cell, Hyperplasia, Cystic | 1 |
Follicular Cell, Hypertrophy | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Acute | 1 3 2 |
Inflammation, Chronic | 1 3 3 2 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 4 1 1 3 2 2 2 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Epithelium, Degeneration | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
Interstitial Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hemorrhage | 2 |
Hypoplasia | 3 |
Myelofibrosis | 1 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|
| 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + M + M + + + + + + +|
Axillary, Hyperplasia, Re Cell | 2 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Re Cell | |
Mesenteric, Congestion | 1 2 |
Mesenteric, Hyperplasia, Re Cell | |
Mesenteric, Pigmentation | 1 2 2 1 1 1 |
Pancreatic, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + M + + + + + + +|
Congestion | |
Ectasia | |
Hemorrhage | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Autolysis | |
Congestion | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + I + + + + + + + + + I + + + +|
Hyperplasia | 2 |
Duct, Ectasia | 1 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic Active | |
Face, Inflammation, Chronic | |
Subcutaneous Tissue, Abscess | 3 |
Tail, Cyst Epithelial Inclusion | X X |
Tail, Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 8| 8| 3| 3| 7| 2| 3| 3| 3| 1| 1| 3| 3| 3| 1| 4| 9| 3| 3| 2| 3| 3| 3| 3|
| 4| 7| 8| 1| 1| 6| 7| 1| 1| 1| 8| 8| 1| 1| 1| 2| 8| 6| 1| 1| 9| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Choroid Plexus, Infiltration | |
Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | |
Inflammation, Granulomatous | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +|
Autolysis | |
Foreign Body | 2 2 |
Fungus | X |
Inflammation, Chronic | 1 |
Mucosa, Inflammation, Chronic Active | 2 2 2 2 |
Mucosa, Glands, Exudate | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 2 1 2 2|
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Bilateral, Lens, Cataract | |
Bilateral, Retina, Degeneration | |
Cornea, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | 3 |
Mineralization | |
Nephropathy | 1 3 1 4 3 3 2 3 3 3 4 2 3 3 3 2 3 3 3 3 2 4 3 4 3|
Cortex, Cyst | 2 |
Renal Tubule, Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 6| 7| 6| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
Autolysis | | 4 2.8|
Diverticulum | | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Autolysis | | 3 3.0|
Hyperplasia, Lymphoid | | 2 1.0|
Hyperplasia, Adenomatous | | 1 2.0|
Parasite Metazoan | | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
Autolysis | | 3 3.0|
Parasite Metazoan | | 8 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
Autolysis | | 3 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
Autolysis | | 3 3.3|
Hyperplasia, Lymphoid | | 15 2.0|
Pigmentation | | 4 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
Autolysis | | 4 3.5|
Hyperplasia, Lymphoid | | 3 2.0|
Pigmentation | | 3 1.3|
__________________________________________________________________________|____________|
Liver | | 50 |
Autolysis | | 1 3.0|
Basophilic Focus, Multiple | | 7 |
Clear Cell Focus | | 5 |
Congestion | | 1 3.0|
Cyst | | 1 2.0|
Ectasia | | 1 2.0|
Eosinophilic Focus | | 4 |
Eosinophilic Focus, Multiple | | 1 |
Hepatodiaphragmatic Nodule | | 6 |
Hyperplasia, Focal | | 5 1.8|
Hypertrophy, Focal | | 4 1.5|
Hypertrophy, Multifocal | | 1 2.0|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 6| 7| 6| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Granulomatous | | 4 1.0|
Vacuolization Cytoplasmic | | 1 1.0|
Bile Duct, Hyperplasia | | 17 1.1|
Centrilobular, Necrosis | | 2 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 2 2.0|
Hepatocyte, Degeneration, Cystic | | 9 1.4|
__________________________________________________________________________|____________|
Mesentery | | 11 |
Inflammation, Chronic | | 1 3.0|
Artery, Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | | 6 1.8|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Atrophy, Diffuse | | 1 4.0|
Atrophy, Focal | | 21 1.3|
Autolysis | | 1 4.0|
Cytoplasmic Alteration | | 1 1.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Artery, Inflammation, Chronic | | 3 3.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Atrophy | | 1 1.0|
Vacuolization Cytoplasmic | | 1 2.0|
Acinar Cell, Cytoplasmic Alteration | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Hyperplasia | | 3 2.0|
Inflammation, Acute | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Mineralization | | 5 1.4|
Mucosa, Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Inflammation, Chronic | | 50 1.7|
Atrium Left, Thrombosis | | 10 3.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 6| 7| 6| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Accessory Adrenal Cortical Nodule | | 1 |
Hyperplasia | | 18 1.2|
Hypertrophy | | 1 2.0|
Vacuolization Cytoplasmic | | 8 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Hyperplasia | | 15 1.4|
Bilateral, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
Autolysis | | 1 4.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | | 49 |
Pars Distalis, Cyst | | 5 2.0|
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia | | 8 1.4|
Pars Distalis, Hypertrophy | | 5 1.0|
Pars Nervosa, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | | 13 1.7|
Follicle, Dilatation | | 4 1.5|
Follicular Cell, Hyperplasia, Cystic | | 1 1.0|
Follicular Cell, Hypertrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 48 |
Granuloma Sperm | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 49 |
Hyperplasia | | 1 3.0|
Inflammation, Acute | | 3 2.0|
Inflammation, Chronic | | 14 1.6|
__________________________________________________________________________|____________|
Prostate | | 49 |
Cyst | | 1 2.0|
Inflammation, Acute | | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 6| 7| 6| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 23 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | | 49 |
Dilatation | | 2 2.0|
Epithelium, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Testes | | 49 |
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 1 2.0|
Interstitial Cell, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Autolysis | | 1 4.0|
Hemorrhage | | 1 2.0|
Hypoplasia | | 3 2.7|
Myelofibrosis | | 1 1.0|
Myeloid Cell, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 48 |
Axillary, Hyperplasia, Re Cell | | 1 2.0|
Mediastinal, Hemorrhage | | 1 1.0|
Mediastinal, Hyperplasia, Re Cell | | 1 2.0|
Mesenteric, Congestion | | 2 1.5|
Mesenteric, Hyperplasia, Re Cell | | 1 2.0|
Mesenteric, Pigmentation | | 10 1.7|
Pancreatic, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 48 |
Congestion | | 1 3.0|
Ectasia | | 1 3.0|
Hemorrhage | | 1 3.0|
Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Spleen | | 50 |
Atrophy | | 1 3.0|
Autolysis | | 1 3.0|
Congestion | | 1 2.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | | 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 6| 7| 6| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 43 |
Hyperplasia | | 6 2.0|
Duct, Ectasia | | 5 2.0|
__________________________________________________________________________|____________|
Skin | | 50 |
Hyperkeratosis | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
Face, Inflammation, Chronic | | 1 3.0|
Subcutaneous Tissue, Abscess | | 1 3.0|
Tail, Cyst Epithelial Inclusion | | 2 |
Tail, Hyperkeratosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Fibrous Osteodystrophy | | 3 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
Compression | | 5 2.0|
Choroid Plexus, Infiltration | | |
Cellular, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Autolysis | | 1 2.0|
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 5 1.2|
Inflammation, Chronic | | 2 1.5|
Inflammation, Granulomatous | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 49 |
Autolysis | | 1 2.0|
Foreign Body | | 5 2.0|
Fungus | | 2 |
Inflammation, Chronic | | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 2| 6| 6| 6| 7| 6| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
5.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Inflammation, Chronic Active | | 9 2.2|
Mucosa, Glands, Exudate | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 11 1.6|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Bilateral, Lens, Cataract | | 1 4.0|
Bilateral, Retina, Degeneration | | 1 3.0|
Cornea, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Autolysis | | 1 3.0|
Congestion | | 1 3.0|
Mineralization | | 1 1.0|
Nephropathy | | 49 2.9|
Cortex, Cyst | | 2 2.0|
Renal Tubule, Hyperplasia | | 8 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 9| 3| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 3| 3|
| 9| 8| 1| 2| 2| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 0| 2| 2| 1| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
Hyperplasia, Lymphoid | 1 3 2 3 3 2 3 |
Inflammation | |
Pigmentation | 2 1 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + |
Hyperplasia, Lymphoid | 4 2 |
Intussusception | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia, Focal | |
Inflammation, Granulomatous | |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 1 1 2 2 2 1 1 1 1 1 1 1 1 1 |
Centrilobular, Necrosis | 1 |
Hepatocyte, Degeneration, Cystic | 2 1|
__________________________________________________________________________|
Mesentery | + + + + + + |
Necrosis, Focal | 2 3 |
__________________________________________________________________________|
Pancreas | + |
Artery, Hypertrophy | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
Atrium Left, Thrombosis | 2 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + +|
Thrombosis | |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + |
Pars Distalis, Cyst | |
Pars Distalis, Pigmentation | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1 |
Follicle, Cyst | 2 |
Follicle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 9| 3| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 3| 3|
| 9| 8| 1| 2| 2| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 0| 2| 2| 1| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + |
__________________________________________________________________________|
Prostate | + |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Hyperplasia, Re Cell | |
Mediastinal, Hemorrhage | |
Mesenteric, Ectasia | |
Mesenteric, Hemorrhage | 2 |
Mesenteric, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Ectasia | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + I I + + + + + + +|
Hemorrhage | |
Hyperplasia | 1 2 1 1 1 1 |
Duct, Ectasia | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Tail, Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + |
Congestion | 3 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 4| 6| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 1| 9| 3| 3| 8| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 3| 3|
| 9| 8| 1| 2| 2| 1| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 0| 2| 2| 1| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | |
Hyperkeratosis | |
Inflammation, Chronic Active | |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Nephropathy | 2 3 3 3 2 2 3 3 3 3 3 3 2 3 3 3 2 3 3 4 3 3 4 3 3|
Cortex, Cyst | 2 |
Renal Tubule, Hyperplasia | 2 4 |
Renal Tubule, Hypertrophy, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 6| 2| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3|
| 7| 6| 7| 2| 2| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 3| 5| 5| 5| 5| 3| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + |
Hyperplasia, Lymphoid | 3 3 3 3 4 3 3 3 |
Inflammation | 3 |
Pigmentation | 1 1 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
Hyperplasia, Lymphoid | 3 |
Intussusception | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X |
Clear Cell Focus | X |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X X X X |
Hyperplasia, Focal | 2 |
Inflammation, Granulomatous | 2 |
Vacuolization Cytoplasmic | 1 1 1 |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 |
Centrilobular, Necrosis | |
Hepatocyte, Degeneration, Cystic | 1 2 1 1 |
__________________________________________________________________________|
Mesentery | + |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + |
Artery, Hypertrophy | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
Atrium Left, Thrombosis | 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
Thrombosis | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | + |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + |
Pars Distalis, Cyst | 2 |
Pars Distalis, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 1 1 3 1 1 2 2|
Follicle, Cyst | 2 |
Follicle, Dilatation | 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 6| 2| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3|
| 7| 6| 7| 2| 2| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 3| 5| 5| 5| 5| 3| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Preputial Gland | + + + |
__________________________________________________________________________|
Prostate | + |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Inguinal, Hyperplasia, Re Cell | 2 |
Mediastinal, Hemorrhage | 2 |
Mesenteric, Ectasia | 4 |
Mesenteric, Hemorrhage | |
Mesenteric, Pigmentation | 2 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Ectasia | 4 |
Hyperplasia | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + I + + + + + + + I + I + + + + + + I + + +|
Hemorrhage | 2 |
Hyperplasia | 2 1 1 |
Duct, Ectasia | 2 2 1 3 |
__________________________________________________________________________|
Skin | + + + + + + +|
Acanthosis | 4 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
Tail, Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | |
Congestion | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 1| 6| 2| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3|
| 7| 6| 7| 2| 2| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 3| 5| 5| 5| 5| 3| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + |
Hyperkeratosis | 4 |
Inflammation, Chronic Active | 3 |
Metaplasia, Squamous | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Nephropathy | 2 3 2 4 2 3 2 2 4 4 2 3 3 2 3 2 3 2 3 4 2 3 3 3|
Cortex, Cyst | 2|
Renal Tubule, Hyperplasia | 1 3 3 |
Renal Tubule, Hypertrophy, Focal | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Small | | 22 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 17 |
Hyperplasia, Lymphoid | | 15 2.8|
Inflammation | | 1 3.0|
Pigmentation | | 6 1.3|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 5 |
Hyperplasia, Lymphoid | | 3 3.0|
Intussusception | | 1 |
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus, Multiple | | 10 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | | 10 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Granulomatous | | 1 2.0|
Vacuolization Cytoplasmic | | 3 1.0|
Bile Duct, Hyperplasia | | 22 1.2|
Centrilobular, Necrosis | | 1 1.0|
Hepatocyte, Degeneration, Cystic | | 6 1.3|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Necrosis, Focal | | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | | 2 |
Artery, Hypertrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 5 |
Atrium Left, Thrombosis | | 5 2.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 5 |
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 1 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 9 |
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | | 19 1.4|
Follicle, Cyst | | 2 2.0|
Follicle, Dilatation | | 3 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | | 8 |
__________________________________________________________________________|____________|
Prostate | | 2 |
Inflammation, Acute | | 2 3.0|
__________________________________________________________________________|____________|
Testes | | 44 |
Atrophy | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | | 9 |
Inguinal, Hyperplasia, Re Cell | | 1 2.0|
Mediastinal, Hemorrhage | | 1 2.0|
Mesenteric, Ectasia | | 1 4.0|
Mesenteric, Hemorrhage | | 1 2.0|
Mesenteric, Pigmentation | | 4 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 3 |
Ectasia | | 1 4.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | | 48 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 3 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 44 |
Hemorrhage | | 1 2.0|
Hyperplasia | | 9 1.2|
Duct, Ectasia | | 7 2.0|
__________________________________________________________________________|____________|
Skin | | 13 |
Acanthosis | | 1 4.0|
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Chronic | | 1 3.0|
Tail, Hyperkeratosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 4 |
Compression | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 3 |
Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Nose | | 1 |
Hyperkeratosis | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
Metaplasia, Squamous | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Congestion | | 2 2.0|
Nephropathy | | 49 2.8|
Cortex, Cyst | | 2 2.0|
Renal Tubule, Hyperplasia | | 5 2.6|
Renal Tubule, Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|
| 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
Autolysis | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
Autolysis | 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Basophilic Focus, Multiple | X |
Clear Cell Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 2 |
Infarct | |
Leukocytosis | 2 2 2 2 2 |
Vacuolization Cytoplasmic | 3 1 2 1 |
Bile Duct, Hyperplasia | 1 2 1 1 1 1 1 |
Hepatocyte, Degeneration, Cystic | 2 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Hemorrhage | 3 |
Inflammation, Chronic | 3 3 |
Necrosis, Focal | 2 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | A |
__________________________________________________________________________|
Salivary Glands | + |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
Inflammation, Chronic | 2 |
Atrium Left, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|
| 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
__________________________________________________________________________|
Islets, Pancreatic | A |
__________________________________________________________________________|
Parathyroid Gland | + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + +|
Pars Distalis, Ectasia | |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 4 1 3 1 2 3 1|
Follicle, Cyst | 2 |
Follicle, Dilatation | |
Follicular Cell, Hyperplasia, Cystic | 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + |
Cyst | 3 |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Prostate | + + |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Seminal Vesicle | |
Dilatation | |
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Hemorrhage | |
Pancreatic, Hyperplasia, Re Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|
| 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 2 |
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | |
Hematopoietic Cell Proliferation | |
Granulocytic | 3 |
Hematopoietic Cell Proliferation | |
Erythrocytic | 2 |
Infarct | 3 |
__________________________________________________________________________|
Thymus | + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + I + + + I + + + + +|
Cyst | 4 |
Galactocele | 3 |
Hyperplasia | 1 2 1 |
Inflammation, Chronic | 3 |
Duct, Ectasia | 2 1 3 1 1 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + |
Acanthosis | 3 |
Subcutaneous Tissue, Cyst | |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 1 |
Tail, Acanthosis | 3 3 2 |
Tail, Hyperkeratosis | 3 3 3 |
Tail, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + |
Hemorrhage | |
__________________________________________________________________________|
Nose | + |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 5| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 1| 9| 8| 3| 3| 0| 8| 3| 3| 3| 8| 1| 2| 3| 3| 9| 4| 2| 3| 3| 9| 2| 3| 3| 9|
| 3| 2| 1| 5| 5| 4| 6| 5| 5| 5| 6| 1| 8| 5| 5| 2| 7| 3| 5| 5| 2| 9| 6| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Congestion | |
Nephropathy | 2 3 3 3 1 4 3 3 2 2 2 3 3 3 2 3 3 3 3 3 4 4 4 2|
Renal Tubule, Hyperplasia | 1 3 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|
| 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
Autolysis | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | + |
Autolysis | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | |
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Basophilic Focus, Multiple | X |
Clear Cell Focus | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 |
Infarct | 1 |
Leukocytosis | 2 2 |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Hyperplasia | 1 1 1 2 1 2 1 |
Hepatocyte, Degeneration, Cystic | 2 |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
Inflammation, Chronic | |
Necrosis, Focal | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Inflammation, Chronic | |
Atrium Left, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|
| 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + +|
Pars Distalis, Ectasia | 4 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 1 2 1 2 1 1 1 1|
Follicle, Cyst | 2 |
Follicle, Dilatation | 3 |
Follicular Cell, Hyperplasia, Cystic | 2 1 3 |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | |
__________________________________________________________________________|
Preputial Gland | + + + + +|
Cyst | |
Inflammation, Acute | 3|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | 2 |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Hemorrhage | 2 |
Pancreatic, Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|
| 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | 4 |
Hematopoietic Cell Proliferation | |
Erythrocytic | |
Infarct | |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + I + + + + + + + + I|
Cyst | |
Galactocele | |
Hyperplasia | 2 2 1 1 |
Inflammation, Chronic | |
Duct, Ectasia | 2 2 1 2 |
__________________________________________________________________________|
Skin | + + + +|
Acanthosis | |
Subcutaneous Tissue, Cyst | 3 |
Subcutaneous Tissue, Fibrosis | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Tail, Acanthosis | 3 |
Tail, Hyperkeratosis | 2 |
Tail, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + |
Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + |
Hemorrhage | 2 |
__________________________________________________________________________|
Nose | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 5| 7| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 1| 1| 2| 3| 3| 2| 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| 5| 2| 3| 3| 7| 7| 3| 3| 3|
| 3| 0| 0| 6| 6| 9| 6| 6| 6| 6| 4| 6| 6| 6| 6| 1| 7| 9| 6| 6| 7| 5| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | 2 |
Nephropathy | 2 2 2 2 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 2 3 2 3 4|
Renal Tubule, Hyperplasia | 2|
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 1 |
__________________________________________________________________________|____________|
Intestine Large | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 1 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 1 |
__________________________________________________________________________|____________|
Intestine Small | | 7 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 7 |
Autolysis | | 1 3.0|
Hyperplasia, Lymphoid | | 6 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Liver | | 50 |
Autolysis | | 2 2.5|
Basophilic Focus, Multiple | | 2 |
Clear Cell Focus | | 1 |
Hepatodiaphragmatic Nodule | | 6 |
Hyperplasia, Focal | | 1 2.0|
Hypertrophy, Focal | | 2 2.0|
Infarct | | 1 1.0|
Leukocytosis | | 7 2.0|
Vacuolization Cytoplasmic | | 5 1.8|
Bile Duct, Hyperplasia | | 14 1.2|
Hepatocyte, Degeneration, Cystic | | 3 1.7|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 2 3.0|
Necrosis, Focal | | 1 2.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | | |
__________________________________________________________________________|____________|
Salivary Glands | | 1 |
__________________________________________________________________________|____________|
Stomach | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 3 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Atrium Left, Thrombosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 7 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 2 |
Hyperplasia | | 1 2.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | |
__________________________________________________________________________|____________|
Parathyroid Gland | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | | 16 |
Pars Distalis, Ectasia | | 1 4.0|
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
C-Cell, Hyperplasia | | 19 1.8|
Follicle, Cyst | | 2 2.0|
Follicle, Dilatation | | 1 3.0|
Follicular Cell, Hyperplasia, Cystic | | 5 1.8|
Follicular Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | | 9 |
Cyst | | 1 3.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | | 3 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 2 |
Dilatation | | 1 2.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Testes | | 44 |
Interstitial Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 2 |
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 7 |
Mediastinal, Hemorrhage | | 1 2.0|
Pancreatic, Hyperplasia, Re Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 2 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Autolysis | | 1 3.0|
Congestion | | 1 2.0|
Fibrosis | | 3 2.3|
Hematopoietic Cell Proliferation | | 1 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 2 3.5|
Hematopoietic Cell Proliferation | | |
Erythrocytic | | 1 2.0|
Infarct | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 46 |
Cyst | | 1 4.0|
Galactocele | | 1 3.0|
Hyperplasia | | 7 1.4|
Inflammation, Chronic | | 1 3.0|
Duct, Ectasia | | 12 1.8|
__________________________________________________________________________|____________|
Skin | | 14 |
Acanthosis | | 1 3.0|
Subcutaneous Tissue, Cyst | | 1 3.0|
Subcutaneous Tissue, Fibrosis | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 1.0|
Tail, Acanthosis | | 4 2.8|
Tail, Hyperkeratosis | | 4 2.8|
Tail, Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05021-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CI PIGMENT RED 23 Date: 04/28/97
Route: DOSED FEED Time: 11:48:44
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 3 |
Compression | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 6 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 1 |
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 4.0|
Retina, Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 48 |
Autolysis | | 1 2.0|
Congestion | | 1 2.0|
Nephropathy | | 48 2.8|
Renal Tubule, Hyperplasia | | 6 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
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