TDMS Study 05024-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) N-METHYLOLACRYLAMIDE NTP Experiment-Test: 05024-02 Report: PEIRPT03 Study Type: CHRONIC Date: 09/04/94 Route: GAVAGE Time: 04:40:23 Facility: Battelle Columbus Laboratory Chemical CAS #: 924-42-5 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94 Route: GAVAGE Time: 04:40:23 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 25 MG/KG 50 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Dead 5 9 10 Moribund 3 6 6 Accident 1 Survivors Terminal Sacrifice 41 35 33 Missing 1 Animals Examined Microscopically 50 50 49 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (45) (6) (44) Infarct 1 (2%) Parasite Metazoan 1 (2%) Intestine Large, Rectum (46) (6) (43) Parasite Metazoan 1 (2%) Intestine Small, Duodenum (44) (5) (41) Inflammation, Chronic Active 1 (20%) Ulcer 1 (20%) Intestine Small, Ileum (44) (4) (43) Inflammation, Necrotizing 1 (2%) Intestine Small, Jejunum (45) (4) (42) Necrosis, Coagulative 1 (2%) Liver (50) (50) (49) Amyloid Deposition 1 (2%) Angiectasis 1 (2%) 1 (2%) Atypia Cellular 2 (4%) Clear Cell Focus 2 (4%) Degeneration, Cystic 1 (2%) Hematopoietic Cell Proliferation 4 (8%) 2 (4%) Infiltration Cellular, Lymphocyte 1 (2%) Inflammation, Chronic 1 (2%) Inflammation, Chronic Active 2 (4%) Leukocytosis 1 (2%) 2 (4%) 1 (2%) Necrosis, Coagulative 4 (8%) 3 (6%) Pigmentation, Hematoidin 1 (2%) Pigmentation, Hemosiderin 1 (2%) Vacuolization Cytoplasmic 1 (2%) 2 (4%) Artery, Necrosis, Fibrinoid 1 (2%) Bile Duct, Cyst 1 (2%) Mesentery (48) (6) (47) Inflammation, Chronic Active 2 (4%) 1 (2%) Necrosis 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94 Route: GAVAGE Time: 04:40:23 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 25 MG/KG 50 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Thrombosis 2 (4%) Pancreas (50) (6) (47) Inflammation, Chronic Active 2 (4%) Acinus, Atrophy 3 (6%) 1 (17%) 4 (9%) Duct, Ectasia 1 (2%) Stomach, Forestomach (46) (6) (44) Acanthosis 3 (7%) 5 (11%) Hyperkeratosis 1 (2%) 1 (2%) Inflammation, Chronic Active 1 (2%) 1 (2%) Stomach, Glandular (47) (5) (44) Inflammation, Chronic Active 1 (2%) 1 (2%) Tooth (50) (6) (48) Dysplasia 1 (2%) 3 (6%) Foreign Body 1 (2%) Inflammation, Chronic Active 2 (4%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (6) (49) Cardiomyopathy, Chronic 1 (2%) 4 (8%) Inflammation, Chronic Active 2 (4%) Mineralization 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (7) (48) Corticomedullary Junction, Degeneration, Fatty 1 (2%) Adrenal Gland, Cortex (50) (6) (47) Accessory Adrenal Cortical Nodule 3 (6%) Cyst 1 (2%) Hematopoietic Cell Proliferation 2 (33%) 1 (2%) Hyperplasia 1 (2%) Hypertrophy 1 (2%) Adrenal Gland, Medulla (50) (7) (48) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 5 (10%) 2 (4%) Islets, Pancreatic (50) (6) (47) Hyperplasia 2 (4%) Parathyroid Gland (31) (5) (28) Cyst 1 (4%) Pituitary Gland (49) (14) (43) Pars Distalis, Cyst 1 (2%) Pars Distalis, Hyperplasia 22 (45%) 4 (29%) 13 (30%) Thyroid Gland (48) (6) (48) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94 Route: GAVAGE Time: 04:40:23 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 25 MG/KG 50 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Inflammation, Chronic Active 2 (4%) 1 (2%) C-Cell, Hyperplasia 1 (2%) 1 (2%) Follicle, Cyst 1 (2%) 3 (6%) Follicular Cell, Hyperplasia 9 (19%) 11 (23%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (50) (45) (47) Atrophy 3 (6%) 39 (87%) 38 (81%) Cyst 10 (20%) 9 (20%) 6 (13%) Hemorrhage, Acute 2 (4%) Inflammation, Suppurative 1 (2%) 1 (2%) Mineralization 1 (2%) 1 (2%) Thrombosis 1 (2%) Uterus (50) (35) (49) Dilatation 2 (6%) 4 (8%) Hemorrhage 5 (14%) 1 (2%) Inflammation, Suppurative 1 (2%) 2 (4%) Thrombosis 1 (2%) Artery, Hyperplasia, Cystic, Glandular 1 (3%) Endometrium, Hyperplasia, Cystic, Glandular 47 (94%) 31 (89%) 45 (92%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Blood (2) Neutrophilia 2 (100%) Bone Marrow (50) (6) (48) Femoral, Hyperplasia 2 (33%) 1 (2%) Femoral, Hyperplasia, Reticulum Cell 1 (2%) Femoral, Myelofibrosis 3 (6%) 1 (2%) Vertebral, Hyperplasia 1 (2%) Vertebral, Myelofibrosis 29 (58%) 10 (21%) Lymph Node (50) (13) (46) Iliac, Thrombosis 1 (2%) Lumbar, Hyperplasia, Lymphoid 1 (2%) Mandibular, Hematopoietic Cell Proliferation 2 (15%) 1 (2%) Mandibular, Hyperplasia, Plasma Cell 3 (7%) Mandibular, Infiltration Cellular, Histiocyte 1 (2%) Renal, Hyperplasia, Lymphoid 1 (8%) Renal, Thrombosis 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94 Route: GAVAGE Time: 04:40:23 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 25 MG/KG 50 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Lymph Node, Mesenteric (11) (7) (13) Angiectasis 3 (23%) Hematopoietic Cell Proliferation 1 (9%) 1 (14%) Hyperplasia, Lymphoid 1 (14%) Hyperplasia, Plasma Cell 1 (8%) Thrombosis 1 (8%) Spleen (50) (19) (48) Cyst 1 (2%) Hematopoietic Cell Proliferation 15 (30%) 10 (53%) 40 (83%) Hyperplasia, Lymphoid 1 (5%) Infarct 1 (2%) Thymus (48) (4) (38) Cyst 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (29) (48) (33) Hyperplasia 1 (3%) Hyperplasia, Cystic 20 (69%) 40 (83%) 29 (88%) Skin (50) (14) (48) Abscess 1 (7%) Alopecia 1 (7%) Foreign Body 1 (7%) 1 (2%) Inflammation, Chronic Active 1 (7%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (50) (6) (48) Fibrosis, Focal 1 (2%) Hemorrhage, Acute 1 (2%) Inflammation, Chronic Active 2 (4%) Artery, Necrosis, Fibrinoid 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (7) (48) Hemorrhage, Acute 1 (2%) Inflammation, Chronic 1 (2%) Peripheral Nerve (47) (43) (42) Sciatic, Degeneration 4 (9%) Spinal Cord (50) (6) (49) White Matter, Degeneration 5 (10%) 1 (17%) 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94 Route: GAVAGE Time: 04:40:23 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 25 MG/KG 50 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (49) Hemorrhage, Acute 1 (2%) 1 (2%) Inflammation, Chronic 12 (24%) 28 (56%) 14 (29%) Pigmentation, Hemosiderin 3 (6%) Alveolar Epithelium, Hyperplasia 8 (16%) 26 (52%) 17 (35%) Nose (50) (6) (48) Inflammation, Chronic Active 1 (2%) Nasolacrimal Duct, Foreign Body 1 (2%) Nasolacrimal Duct, Granuloma 1 (2%) Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 5 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (2) Lens, Cataract 2 (100%) Retina, Atrophy 2 (100%) Harderian Gland (47) (45) (48) Hyperplasia 1 (2%) 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (11) (48) Amyloid Deposition 1 (9%) Atrophy 1 (9%) Hydronephrosis 1 (2%) Infarct 5 (10%) Inflammation 1 (9%) Metaplasia, Osseous 2 (4%) 3 (6%) Mineralization 1 (2%) Necrosis 1 (2%) Nephropathy, Chronic 10 (20%) 3 (27%) 23 (48%) Renal Tubule, Regeneration 1 (2%) Urinary Bladder (43) (6) (47) Hemorrhage 1 (17%) Inflammation, Chronic Active 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94 Route: GAVAGE Time: 04:40:23 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 25 MG/KG 50 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Moribund 12 14 10 Dead 8 16 19 Survivors Terminal Sacrifice 29 20 20 Moribund 1 Dead 1 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (44) (12) (33) Inflammation, Chronic Active 1 (2%) 1 (3%) Intestine Large, Colon (45) (16) (43) Parasite Metazoan 1 (2%) Intestine Large, Rectum (43) (11) (42) Parasite Metazoan 1 (2%) Liver (50) (50) (50) Basophilic Focus 1 (2%) Clear Cell Focus 1 (2%) Cyst 1 (2%) Hematopoietic Cell Proliferation 2 (4%) 1 (2%) Hemorrhage 1 (2%) Hepatodiaphragmatic Nodule 2 (4%) Inflammation, Chronic 1 (2%) Inflammation, Necrotizing 1 (2%) Leukocytosis 2 (4%) 3 (6%) Mineralization 1 (2%) Necrosis, Coagulative 5 (10%) 3 (6%) 8 (16%) Pigmentation, Hematoidin 1 (2%) Vacuolization Cytoplasmic 2 (4%) Mesentery (43) (18) (49) Inflammation, Chronic Active 1 (2%) 3 (6%) Necrosis 1 (2%) Pancreas (49) (21) (47) Cyst 1 (5%) Inflammation, Chronic Active 1 (2%) Necrosis, Coagulative 1 (5%) 1 (2%) Acinus, Atrophy 1 (2%) Salivary Glands (49) (20) (50) Inflammation, Chronic Active 1 (5%) Necrosis, Coagulative 1 (2%) Stomach, Forestomach (50) (49) (48) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94 Route: GAVAGE Time: 04:40:23 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 25 MG/KG 50 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Acanthosis 20 (40%) 23 (47%) 26 (54%) Acanthosis, Multiple 1 (2%) Hyperkeratosis 4 (8%) 1 (2%) 8 (17%) Inflammation, Chronic Active 2 (4%) 1 (2%) Stomach, Glandular (50) (20) (45) Cyst 1 (5%) Inflammation, Chronic Active 1 (2%) Tooth (50) (20) (50) Dysplasia 2 (4%) 8 (16%) Foreign Body 1 (2%) Inflammation, Chronic Active 4 (8%) 2 (4%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (47) (19) (34) Mesenteric Artery, Inflammation, Chronic Active 1 (2%) Mesenteric Artery, Necrosis, Fibrinoid 1 (2%) Pulmonary Artery, Inflammation, Chronic Active 1 (2%) Pulmonary Artery, Necrosis, Fibrinoid 1 (2%) Renal Artery, Inflammation, Chronic Active 1 (2%) Renal Artery, Necrosis, Fibrinoid 1 (2%) Renal Artery, Thrombosis 1 (2%) Thoracic, Inflammation, Chronic Active 1 (2%) Thoracic, Necrosis, Fibrinoid 1 (2%) Heart (50) (20) (50) Cardiomyopathy, Chronic 4 (8%) Inflammation, Suppurative 2 (4%) Mineralization 1 (2%) Atrium, Thrombosis 1 (2%) Coronary Artery, Inflammation, Chronic Active 1 (2%) Coronary Artery, Necrosis, Fibrinoid 1 (2%) Valve, Bacterium 1 (2%) 2 (10%) 4 (8%) Valve, Inflammation, Suppurative 2 (10%) Valve, Thrombosis 1 (2%) 2 (10%) 5 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (48) (21) (48) Accessory Adrenal Cortical Nodule 1 (2%) 2 (4%) Hyperplasia 2 (4%) 1 (5%) 1 (2%) Hypertrophy 3 (6%) 5 (10%) Adrenal Gland, Medulla (48) (20) (50) Hyperplasia 3 (6%) 1 (5%) 5 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94 Route: GAVAGE Time: 04:40:23 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 25 MG/KG 50 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Islets, Pancreatic (50) (19) (47) Hyperplasia 2 (4%) Pituitary Gland (48) (14) (42) Pars Distalis, Cyst 2 (4%) 2 (5%) Pars Distalis, Hyperplasia 1 (2%) Thyroid Gland (50) (20) (49) Inflammation, Chronic Active 1 (2%) Necrosis, Fibrinoid 1 (2%) Ultimobranchial Cyst 1 (5%) Follicular Cell, Hyperplasia 1 (2%) 5 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Coagulating Gland (26) (18) (46) Dilatation 2 (4%) Inflammation, Suppurative 1 (2%) Epididymis (50) (20) (50) Inflammation, Chronic Active 1 (5%) Penis (3) (2) (4) Inflammation, Chronic Active 1 (50%) 1 (25%) Mineralization 1 (33%) Preputial Gland (3) (9) (6) Inflammation, Chronic Active 3 (100%) 1 (11%) 4 (67%) Duct, Ectasia 1 (11%) Lymphatic, Ectasia 1 (11%) 1 (17%) Prostate (49) (20) (50) Inflammation, Chronic Active 4 (8%) 3 (15%) 1 (2%) Artery, Necrosis, Fibrinoid 1 (2%) Seminal Vesicle (29) (18) (36) Dilatation 5 (17%) 1 (6%) 4 (11%) Inflammation, Chronic Active 2 (7%) 1 (6%) 1 (3%) Inflammation, Suppurative 1 (3%) Testes (50) (20) (50) Mineralization 1 (5%) Interstitial Cell, Hyperplasia 1 (2%) 1 (5%) Seminiferous Tubule, Atrophy 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94 Route: GAVAGE Time: 04:40:23 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 25 MG/KG 50 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Blood (3) (2) Neutrophilia 1 (33%) 2 (100%) Bone Marrow (50) (20) (50) Femoral, Hyperplasia 2 (4%) 3 (15%) 6 (12%) Lymph Node (49) (32) (50) Hematopoietic Cell Proliferation 1 (3%) Axillary, Hemorrhage, Acute 1 (2%) Axillary, Hyperplasia, Lymphoid 1 (2%) Lumbar, Hyperplasia, Plasma Cell 1 (3%) Mandibular, Hematopoietic Cell Proliferation 1 (3%) Mandibular, Hyperplasia 1 (3%) Mandibular, Hyperplasia, Lymphoid 1 (2%) 1 (2%) Mandibular, Hyperplasia, Plasma Cell 1 (2%) 3 (6%) Mandibular, Inflammation, Suppurative 1 (2%) Mandibular, Necrosis 1 (2%) Mediastinal, Inflammation, Suppurative 2 (4%) Renal, Hematopoietic Cell Proliferation 1 (3%) Lymph Node, Mesenteric (19) (17) (24) Angiectasis 10 (53%) 10 (59%) 14 (58%) Hematopoietic Cell Proliferation 11 (58%) 11 (65%) 10 (42%) Hyperplasia, Lymphoid 1 (5%) 1 (4%) Hyperplasia, Reticulum Cell 1 (5%) Spleen (50) (26) (50) Depletion Lymphoid 2 (4%) Fibrosis 1 (2%) Hematopoietic Cell Proliferation 11 (22%) 13 (50%) 38 (76%) Infarct 2 (4%) Necrosis 1 (2%) 1 (4%) Thymus (36) (13) (39) Cyst 3 (8%) Necrosis 1 (3%) 6 (46%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (33) (50) Abscess 2 (6%) Acanthosis 3 (6%) 1 (2%) Alopecia 1 (2%) Edema 1 (2%) Fibrosis 1 (2%) 2 (4%) Hyperkeratosis 2 (4%) 1 (2%) Inflammation, Chronic Active 7 (14%) 9 (27%) 6 (12%) Inflammation, Suppurative 1 (2%) 1 (3%) 2 (4%) Metaplasia, Osseous 1 (3%) Necrosis, Coagulative 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94 Route: GAVAGE Time: 04:40:23 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 25 MG/KG 50 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - CONT Lymphatic, Ectasia 1 (2%) Prepuce, Concretion 1 (3%) Prepuce, Dilatation 1 (3%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (34) (50) Joint, Femur, Tibia, Metaplasia, Osseous 1 (2%) 1 (3%) Joint, Tarsal, Metaplasia, Osseous 24 (48%) 16 (47%) 11 (22%) Sternum, Developmental Malformation 1 (3%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (20) (50) Hemorrhage, Acute 1 (2%) Inflammation, Chronic Active 1 (2%) Artery, Cerebrum, Necrosis, Fibrinoid 1 (2%) Peripheral Nerve (47) (39) (43) Sciatic, Degeneration 1 (3%) 3 (7%) Spinal Cord (48) (20) (49) White Matter, Degeneration 2 (4%) 3 (6%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (50) (50) Hemorrhage, Acute 2 (4%) 2 (4%) Inflammation, Chronic 8 (16%) 12 (24%) 20 (40%) Leukocytosis 1 (2%) 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 10 (20%) 17 (34%) 19 (38%) Nose (50) (20) (50) Foreign Body 1 (5%) Granuloma 1 (5%) Inflammation, Chronic Active 1 (2%) 1 (2%) Nasolacrimal Duct, Inflammation, Suppurative 3 (6%) 1 (5%) 3 (6%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (2) (4) Cornea, Inflammation, Chronic Active 1 (25%) Lens, Cataract 2 (100%) 1 (25%) Retina, Atrophy 1 (50%) Harderian Gland (48) (49) (50) Hyperplasia 1 (2%) 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94 Route: GAVAGE Time: 04:40:23 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 25 MG/KG 50 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (22) (50) Atrophy 1 (2%) Bacterium 1 (5%) Cyst 1 (2%) Hemorrhage 1 (2%) Hydronephrosis 1 (2%) 1 (5%) Infarct 2 (4%) 3 (14%) 8 (16%) Inflammation, Suppurative 3 (6%) 3 (14%) 1 (2%) Mineralization 3 (14%) 8 (16%) Nephropathy, Chronic 21 (42%) 4 (18%) 22 (44%) Thrombosis 1 (2%) Artery, Inflammation, Chronic Active 2 (4%) Artery, Necrosis, Fibrinoid 2 (4%) Ureter (39) (15) (38) Inflammation, Chronic Active 1 (3%) Inflammation, Suppurative 1 (3%) Urethra (30) (8) (35) Concretion 2 (7%) 4 (50%) Inflammation, Chronic Active 1 (3%) 2 (25%) 1 (3%) Inflammation, Suppurative 1 (3%) Urinary Bladder (49) (21) (49) Dilatation 3 (6%) 8 (38%) 2 (4%) Inflammation, Chronic Active 2 (4%) 1 (5%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 81214-81214/81214 --multipart-boundary--