TDMS Study 05024-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
N-METHYLOLACRYLAMIDE
NTP Experiment-Test: 05024-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/04/94
Route: GAVAGE Time: 04:40:23
Facility: Battelle Columbus Laboratory
Chemical CAS #: 924-42-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 04:40:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 5 9 10
Moribund 3 6 6
Accident 1
Survivors
Terminal Sacrifice 41 35 33
Missing 1
Animals Examined Microscopically 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (45) (6) (44)
Infarct 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Large, Rectum (46) (6) (43)
Parasite Metazoan 1 (2%)
Intestine Small, Duodenum (44) (5) (41)
Inflammation, Chronic Active 1 (20%)
Ulcer 1 (20%)
Intestine Small, Ileum (44) (4) (43)
Inflammation, Necrotizing 1 (2%)
Intestine Small, Jejunum (45) (4) (42)
Necrosis, Coagulative 1 (2%)
Liver (50) (50) (49)
Amyloid Deposition 1 (2%)
Angiectasis 1 (2%) 1 (2%)
Atypia Cellular 2 (4%)
Clear Cell Focus 2 (4%)
Degeneration, Cystic 1 (2%)
Hematopoietic Cell Proliferation 4 (8%) 2 (4%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 2 (4%)
Leukocytosis 1 (2%) 2 (4%) 1 (2%)
Necrosis, Coagulative 4 (8%) 3 (6%)
Pigmentation, Hematoidin 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 2 (4%)
Artery, Necrosis, Fibrinoid 1 (2%)
Bile Duct, Cyst 1 (2%)
Mesentery (48) (6) (47)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Necrosis 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 04:40:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Thrombosis 2 (4%)
Pancreas (50) (6) (47)
Inflammation, Chronic Active 2 (4%)
Acinus, Atrophy 3 (6%) 1 (17%) 4 (9%)
Duct, Ectasia 1 (2%)
Stomach, Forestomach (46) (6) (44)
Acanthosis 3 (7%) 5 (11%)
Hyperkeratosis 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Stomach, Glandular (47) (5) (44)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Tooth (50) (6) (48)
Dysplasia 1 (2%) 3 (6%)
Foreign Body 1 (2%)
Inflammation, Chronic Active 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (6) (49)
Cardiomyopathy, Chronic 1 (2%) 4 (8%)
Inflammation, Chronic Active 2 (4%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (7) (48)
Corticomedullary Junction, Degeneration,
Fatty 1 (2%)
Adrenal Gland, Cortex (50) (6) (47)
Accessory Adrenal Cortical Nodule 3 (6%)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 2 (33%) 1 (2%)
Hyperplasia 1 (2%)
Hypertrophy 1 (2%)
Adrenal Gland, Medulla (50) (7) (48)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 5 (10%) 2 (4%)
Islets, Pancreatic (50) (6) (47)
Hyperplasia 2 (4%)
Parathyroid Gland (31) (5) (28)
Cyst 1 (4%)
Pituitary Gland (49) (14) (43)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 22 (45%) 4 (29%) 13 (30%)
Thyroid Gland (48) (6) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 04:40:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Inflammation, Chronic Active 2 (4%) 1 (2%)
C-Cell, Hyperplasia 1 (2%) 1 (2%)
Follicle, Cyst 1 (2%) 3 (6%)
Follicular Cell, Hyperplasia 9 (19%) 11 (23%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (45) (47)
Atrophy 3 (6%) 39 (87%) 38 (81%)
Cyst 10 (20%) 9 (20%) 6 (13%)
Hemorrhage, Acute 2 (4%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Uterus (50) (35) (49)
Dilatation 2 (6%) 4 (8%)
Hemorrhage 5 (14%) 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Artery, Hyperplasia, Cystic, Glandular 1 (3%)
Endometrium, Hyperplasia, Cystic, Glandular 47 (94%) 31 (89%) 45 (92%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2)
Neutrophilia 2 (100%)
Bone Marrow (50) (6) (48)
Femoral, Hyperplasia 2 (33%) 1 (2%)
Femoral, Hyperplasia, Reticulum Cell 1 (2%)
Femoral, Myelofibrosis 3 (6%) 1 (2%)
Vertebral, Hyperplasia 1 (2%)
Vertebral, Myelofibrosis 29 (58%) 10 (21%)
Lymph Node (50) (13) (46)
Iliac, Thrombosis 1 (2%)
Lumbar, Hyperplasia, Lymphoid 1 (2%)
Mandibular, Hematopoietic Cell Proliferation 2 (15%) 1 (2%)
Mandibular, Hyperplasia, Plasma Cell 3 (7%)
Mandibular, Infiltration Cellular, Histiocyte 1 (2%)
Renal, Hyperplasia, Lymphoid 1 (8%)
Renal, Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 04:40:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mesenteric (11) (7) (13)
Angiectasis 3 (23%)
Hematopoietic Cell Proliferation 1 (9%) 1 (14%)
Hyperplasia, Lymphoid 1 (14%)
Hyperplasia, Plasma Cell 1 (8%)
Thrombosis 1 (8%)
Spleen (50) (19) (48)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 15 (30%) 10 (53%) 40 (83%)
Hyperplasia, Lymphoid 1 (5%)
Infarct 1 (2%)
Thymus (48) (4) (38)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (29) (48) (33)
Hyperplasia 1 (3%)
Hyperplasia, Cystic 20 (69%) 40 (83%) 29 (88%)
Skin (50) (14) (48)
Abscess 1 (7%)
Alopecia 1 (7%)
Foreign Body 1 (7%) 1 (2%)
Inflammation, Chronic Active 1 (7%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (50) (6) (48)
Fibrosis, Focal 1 (2%)
Hemorrhage, Acute 1 (2%)
Inflammation, Chronic Active 2 (4%)
Artery, Necrosis, Fibrinoid 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (7) (48)
Hemorrhage, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Peripheral Nerve (47) (43) (42)
Sciatic, Degeneration 4 (9%)
Spinal Cord (50) (6) (49)
White Matter, Degeneration 5 (10%) 1 (17%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 04:40:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49)
Hemorrhage, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 12 (24%) 28 (56%) 14 (29%)
Pigmentation, Hemosiderin 3 (6%)
Alveolar Epithelium, Hyperplasia 8 (16%) 26 (52%) 17 (35%)
Nose (50) (6) (48)
Inflammation, Chronic Active 1 (2%)
Nasolacrimal Duct, Foreign Body 1 (2%)
Nasolacrimal Duct, Granuloma 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 5 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2)
Lens, Cataract 2 (100%)
Retina, Atrophy 2 (100%)
Harderian Gland (47) (45) (48)
Hyperplasia 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (11) (48)
Amyloid Deposition 1 (9%)
Atrophy 1 (9%)
Hydronephrosis 1 (2%)
Infarct 5 (10%)
Inflammation 1 (9%)
Metaplasia, Osseous 2 (4%) 3 (6%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Nephropathy, Chronic 10 (20%) 3 (27%) 23 (48%)
Renal Tubule, Regeneration 1 (2%)
Urinary Bladder (43) (6) (47)
Hemorrhage 1 (17%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 04:40:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 12 14 10
Dead 8 16 19
Survivors
Terminal Sacrifice 29 20 20
Moribund 1
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (44) (12) (33)
Inflammation, Chronic Active 1 (2%) 1 (3%)
Intestine Large, Colon (45) (16) (43)
Parasite Metazoan 1 (2%)
Intestine Large, Rectum (43) (11) (42)
Parasite Metazoan 1 (2%)
Liver (50) (50) (50)
Basophilic Focus 1 (2%)
Clear Cell Focus 1 (2%)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Necrotizing 1 (2%)
Leukocytosis 2 (4%) 3 (6%)
Mineralization 1 (2%)
Necrosis, Coagulative 5 (10%) 3 (6%) 8 (16%)
Pigmentation, Hematoidin 1 (2%)
Vacuolization Cytoplasmic 2 (4%)
Mesentery (43) (18) (49)
Inflammation, Chronic Active 1 (2%) 3 (6%)
Necrosis 1 (2%)
Pancreas (49) (21) (47)
Cyst 1 (5%)
Inflammation, Chronic Active 1 (2%)
Necrosis, Coagulative 1 (5%) 1 (2%)
Acinus, Atrophy 1 (2%)
Salivary Glands (49) (20) (50)
Inflammation, Chronic Active 1 (5%)
Necrosis, Coagulative 1 (2%)
Stomach, Forestomach (50) (49) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 04:40:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acanthosis 20 (40%) 23 (47%) 26 (54%)
Acanthosis, Multiple 1 (2%)
Hyperkeratosis 4 (8%) 1 (2%) 8 (17%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Stomach, Glandular (50) (20) (45)
Cyst 1 (5%)
Inflammation, Chronic Active 1 (2%)
Tooth (50) (20) (50)
Dysplasia 2 (4%) 8 (16%)
Foreign Body 1 (2%)
Inflammation, Chronic Active 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (47) (19) (34)
Mesenteric Artery, Inflammation, Chronic
Active 1 (2%)
Mesenteric Artery, Necrosis, Fibrinoid 1 (2%)
Pulmonary Artery, Inflammation, Chronic
Active 1 (2%)
Pulmonary Artery, Necrosis, Fibrinoid 1 (2%)
Renal Artery, Inflammation, Chronic Active 1 (2%)
Renal Artery, Necrosis, Fibrinoid 1 (2%)
Renal Artery, Thrombosis 1 (2%)
Thoracic, Inflammation, Chronic Active 1 (2%)
Thoracic, Necrosis, Fibrinoid 1 (2%)
Heart (50) (20) (50)
Cardiomyopathy, Chronic 4 (8%)
Inflammation, Suppurative 2 (4%)
Mineralization 1 (2%)
Atrium, Thrombosis 1 (2%)
Coronary Artery, Inflammation, Chronic Active 1 (2%)
Coronary Artery, Necrosis, Fibrinoid 1 (2%)
Valve, Bacterium 1 (2%) 2 (10%) 4 (8%)
Valve, Inflammation, Suppurative 2 (10%)
Valve, Thrombosis 1 (2%) 2 (10%) 5 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (21) (48)
Accessory Adrenal Cortical Nodule 1 (2%) 2 (4%)
Hyperplasia 2 (4%) 1 (5%) 1 (2%)
Hypertrophy 3 (6%) 5 (10%)
Adrenal Gland, Medulla (48) (20) (50)
Hyperplasia 3 (6%) 1 (5%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 04:40:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Islets, Pancreatic (50) (19) (47)
Hyperplasia 2 (4%)
Pituitary Gland (48) (14) (42)
Pars Distalis, Cyst 2 (4%) 2 (5%)
Pars Distalis, Hyperplasia 1 (2%)
Thyroid Gland (50) (20) (49)
Inflammation, Chronic Active 1 (2%)
Necrosis, Fibrinoid 1 (2%)
Ultimobranchial Cyst 1 (5%)
Follicular Cell, Hyperplasia 1 (2%) 5 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (26) (18) (46)
Dilatation 2 (4%)
Inflammation, Suppurative 1 (2%)
Epididymis (50) (20) (50)
Inflammation, Chronic Active 1 (5%)
Penis (3) (2) (4)
Inflammation, Chronic Active 1 (50%) 1 (25%)
Mineralization 1 (33%)
Preputial Gland (3) (9) (6)
Inflammation, Chronic Active 3 (100%) 1 (11%) 4 (67%)
Duct, Ectasia 1 (11%)
Lymphatic, Ectasia 1 (11%) 1 (17%)
Prostate (49) (20) (50)
Inflammation, Chronic Active 4 (8%) 3 (15%) 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Seminal Vesicle (29) (18) (36)
Dilatation 5 (17%) 1 (6%) 4 (11%)
Inflammation, Chronic Active 2 (7%) 1 (6%) 1 (3%)
Inflammation, Suppurative 1 (3%)
Testes (50) (20) (50)
Mineralization 1 (5%)
Interstitial Cell, Hyperplasia 1 (2%) 1 (5%)
Seminiferous Tubule, Atrophy 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 04:40:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (3) (2)
Neutrophilia 1 (33%) 2 (100%)
Bone Marrow (50) (20) (50)
Femoral, Hyperplasia 2 (4%) 3 (15%) 6 (12%)
Lymph Node (49) (32) (50)
Hematopoietic Cell Proliferation 1 (3%)
Axillary, Hemorrhage, Acute 1 (2%)
Axillary, Hyperplasia, Lymphoid 1 (2%)
Lumbar, Hyperplasia, Plasma Cell 1 (3%)
Mandibular, Hematopoietic Cell Proliferation 1 (3%)
Mandibular, Hyperplasia 1 (3%)
Mandibular, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Mandibular, Hyperplasia, Plasma Cell 1 (2%) 3 (6%)
Mandibular, Inflammation, Suppurative 1 (2%)
Mandibular, Necrosis 1 (2%)
Mediastinal, Inflammation, Suppurative 2 (4%)
Renal, Hematopoietic Cell Proliferation 1 (3%)
Lymph Node, Mesenteric (19) (17) (24)
Angiectasis 10 (53%) 10 (59%) 14 (58%)
Hematopoietic Cell Proliferation 11 (58%) 11 (65%) 10 (42%)
Hyperplasia, Lymphoid 1 (5%) 1 (4%)
Hyperplasia, Reticulum Cell 1 (5%)
Spleen (50) (26) (50)
Depletion Lymphoid 2 (4%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 11 (22%) 13 (50%) 38 (76%)
Infarct 2 (4%)
Necrosis 1 (2%) 1 (4%)
Thymus (36) (13) (39)
Cyst 3 (8%)
Necrosis 1 (3%) 6 (46%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (33) (50)
Abscess 2 (6%)
Acanthosis 3 (6%) 1 (2%)
Alopecia 1 (2%)
Edema 1 (2%)
Fibrosis 1 (2%) 2 (4%)
Hyperkeratosis 2 (4%) 1 (2%)
Inflammation, Chronic Active 7 (14%) 9 (27%) 6 (12%)
Inflammation, Suppurative 1 (2%) 1 (3%) 2 (4%)
Metaplasia, Osseous 1 (3%)
Necrosis, Coagulative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 04:40:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Lymphatic, Ectasia 1 (2%)
Prepuce, Concretion 1 (3%)
Prepuce, Dilatation 1 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (34) (50)
Joint, Femur, Tibia, Metaplasia, Osseous 1 (2%) 1 (3%)
Joint, Tarsal, Metaplasia, Osseous 24 (48%) 16 (47%) 11 (22%)
Sternum, Developmental Malformation 1 (3%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (20) (50)
Hemorrhage, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
Artery, Cerebrum, Necrosis, Fibrinoid 1 (2%)
Peripheral Nerve (47) (39) (43)
Sciatic, Degeneration 1 (3%) 3 (7%)
Spinal Cord (48) (20) (49)
White Matter, Degeneration 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50)
Hemorrhage, Acute 2 (4%) 2 (4%)
Inflammation, Chronic 8 (16%) 12 (24%) 20 (40%)
Leukocytosis 1 (2%) 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 10 (20%) 17 (34%) 19 (38%)
Nose (50) (20) (50)
Foreign Body 1 (5%)
Granuloma 1 (5%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 3 (6%) 1 (5%) 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2) (4)
Cornea, Inflammation, Chronic Active 1 (25%)
Lens, Cataract 2 (100%) 1 (25%)
Retina, Atrophy 1 (50%)
Harderian Gland (48) (49) (50)
Hyperplasia 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05024-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 04:40:23
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (22) (50)
Atrophy 1 (2%)
Bacterium 1 (5%)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Hydronephrosis 1 (2%) 1 (5%)
Infarct 2 (4%) 3 (14%) 8 (16%)
Inflammation, Suppurative 3 (6%) 3 (14%) 1 (2%)
Mineralization 3 (14%) 8 (16%)
Nephropathy, Chronic 21 (42%) 4 (18%) 22 (44%)
Thrombosis 1 (2%)
Artery, Inflammation, Chronic Active 2 (4%)
Artery, Necrosis, Fibrinoid 2 (4%)
Ureter (39) (15) (38)
Inflammation, Chronic Active 1 (3%)
Inflammation, Suppurative 1 (3%)
Urethra (30) (8) (35)
Concretion 2 (7%) 4 (50%)
Inflammation, Chronic Active 1 (3%) 2 (25%) 1 (3%)
Inflammation, Suppurative 1 (3%)
Urinary Bladder (49) (21) (49)
Dilatation 3 (6%) 8 (38%) 2 (4%)
Inflammation, Chronic Active 2 (4%) 1 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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