TDMS Study 05024-02 Pathology Tables
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
Facility: Battelle Columbus Laboratory
Chemical CAS #: 924-42-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + A + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + M + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Hemangioma, Multiple | |
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + M M M + M + + M M M + + + + M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
Pars Distalis, Adenoma, Multiple | X |
Pars Intermedia, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + M + +|
Lymphoma Malignant Histiocytic | X |
Bilateral, Follicular Cell, Adenoma, | |
Multiple | X |
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Polyp Stromal | X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Lymphoma Malignant | |
Histiocytic | |
Inguinal, Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant Mixed | |
Mandibular, Lymphoma Malignant | |
Histiocytic | X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant Mixed | X X |
Mediastinal, Hepatocellular | |
Carcinoma, Metastatic, Liver | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X X |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + M M + + M M M + A M M M M M M M + M M M M M|
Lymphoma Malignant Histiocytic | X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M + M + + + + + M + + M M + + M M M M M|
Adenocarcinoma | X |
Adenoma | X X |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibrosarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Mediastinum, Hemangiosarcoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Ureter | + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| |
| 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + M + + + + + + + + + A| 45 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A| 46 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + A| 44 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A| 45 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Hemangioma, Multiple | X | 1 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X | 3 |
Hepatocellular Adenoma | X | 2 |
Hepatocellular Adenoma, Multiple | X | 1 |
Lymphoma Malignant Histiocytic | X | 3 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | X X X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| |
| 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M M + + M + + M M + + M + M + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Pars Distalis, Adenoma | X X X X X X X X X | 12 |
Pars Distalis, Adenoma, Multiple | | 1 |
Pars Intermedia, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | | 1 |
Bilateral, Follicular Cell, Adenoma, | | |
Multiple | | 1 |
Follicular Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| |
| 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hemangiosarcoma | | 1 |
Polyp Stromal | X | 2 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Deep Cervical, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Inguinal, Lymphoma Malignant Mixed | X | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X | 2 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X X X X | 5 |
Mandibular, Lymphoma Malignant Mixed | X | 3 |
Mediastinal, Hepatocellular | | |
Carcinoma, Metastatic, Liver | | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 2 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M + M M M M M M M + + M M + M M M M M M M + M M| 11 |
Lymphoma Malignant Histiocytic | X X | 5 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X | 5 |
Lymphoma Malignant Lymphocytic | X X X X X X | 7 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | X | 3 |
Lymphoma Malignant Lymphocytic | X X X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| |
| 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + M + + + M + + + + + M M + M M + + +| 29 |
Adenocarcinoma | | 1 |
Adenoma | | 2 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sebaceous Gland, Adenoma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + M + + + + + + + + + + + M| 47 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Alveolar/Bronchiolar Adenoma | X X | 4 |
Alveolar/Bronchiolar Carcinoma | X X | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Histiocytic | X X | 3 |
Lymphoma Malignant Lymphocytic | X X X X X | 5 |
Lymphoma Malignant Mixed | | 1 |
Mediastinum, Hemangiosarcoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| |
| 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | M + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
Adenoma | X X X | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | X X X | 4 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Ureter | + + + M + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + A| 43 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X | 5 |
Lymphoma Malignant Lymphocytic | X X X X X X | 7 |
Lymphoma Malignant Mixed | X X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|
| 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + |
__________________________________________________________________________|
Gallbladder | A + |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | M + + |
Leiomyoma | X |
__________________________________________________________________________|
Intestine Large, Colon | + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + |
__________________________________________________________________________|
Intestine Small | + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | M + |
__________________________________________________________________________|
Intestine Small, Jejunum | M + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + |
__________________________________________________________________________|
Stomach, Forestomach | + + |
__________________________________________________________________________|
Stomach, Glandular | A + |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + |
Pheochromocytoma Benign | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|
| 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + |
Lymphoma Malignant | X |
__________________________________________________________________________|
Parathyroid Gland | M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Adenocarcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + I + + I + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Oviduct | + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | |
Leiomyoma | |
Polyp Stromal | X |
__________________________________________________________________________|
Vagina | |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + |
__________________________________________________________________________|
Lymph Node | + + + + + |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant | X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant | X |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|
| 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | |
Pancreatic, Lymphoma Malignant | X |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + |
Hemangiosarcoma, Metastatic, Skin | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X |
__________________________________________________________________________|
Thymus | M M |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma | |
Adenoma | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + |
Lymphoma Malignant | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Hemangiosarcoma | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
__________________________________________________________________________|
Skeletal Muscle | + + |
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
__________________________________________________________________________|
Peripheral Nerve | + + + + + I I + + + + + + + + + + + + + + + + + I|
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma, Metastatic, Mammary | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|
| 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Gland | |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Basosquamous Tumor Malignant | |
Carcinoma, Metastatic, Harderian | |
Gland | |
Hemangiosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + |
__________________________________________________________________________|
Trachea | + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + M + M + + + + + + + M + + + +|
Adenoma | X X X X |
Adenoma, Multiple | X |
Carcinoma | X |
Bilateral, Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 6 |
__________________________________________________________________________|____________|
Gallbladder | + A + + | 4 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + | 5 |
Leiomyoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + | 5 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + | 4 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma | X | 3 |
Hepatocellular Adenoma | X | 3 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X X | 4 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 6 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 7 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 5 |
__________________________________________________________________________|____________|
Tooth | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 6 |
__________________________________________________________________________|____________|
Heart | + + + + | 6 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 7 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 6 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 7 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 6 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 14 |
Pars Distalis, Adenoma | X X X | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + M + + + + I M +| 45 |
Granulosa Cell Tumor Benign | X X X | 5 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Oviduct | + + + + | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 35 |
Hemangioma | X | 1 |
Hemangiosarcoma | X | 1 |
Leiomyoma | X | 1 |
Polyp Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | + + | 2 |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 13 |
Deep Cervical, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Lumbar, Lymphoma Malignant | | 1 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Mandibular, Lymphoma Malignant | | 1 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 2 |
Renal, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + M + M + | 7 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + +| 19 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X| 6 |
__________________________________________________________________________|____________|
Thymus | M + M + + + | 4 |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + M +| 48 |
Adenoacanthoma | X | 1 |
Adenoma | X | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 14 |
Lymphoma Malignant | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X X | 2 |
Subcutaneous Tissue, Hemangiosarcoma | | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 6 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + | 6 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 7 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + M + + + + + M + + + + M + M| 43 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoacanthoma, Metastatic, Mammary | | |
Gland | X | 1 |
Alveolar/Bronchiolar Adenoma | X X | 3 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X | 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Basosquamous Tumor Malignant | X | 1 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + | 6 |
__________________________________________________________________________|____________|
Trachea | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + I + + + + + + + + + + + + M + + + + + + + + +| 45 |
Adenoma | X X | 6 |
Adenoma, Multiple | | 1 |
Carcinoma | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Bilateral, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 11 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + M + + + | 6 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X X X| 7 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|
| 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A A + + + + M + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large | + + A A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + A|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small | + + A A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + A|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + A|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Pancreas | + + A A + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + M + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + A A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + A A + + + + + + + + + + + + + + + + + + + A|
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + A A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|
| 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Capsule, Carcinoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + A A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Parathyroid Gland | M M + M + M + + M M + + + + M M + + M M + + M M|
__________________________________________________________________________|
Pituitary Gland | + + M + + + M + + + + + + + M + + + + + + M + +|
Pars Distalis, Adenoma | X X X |
Pars Intermedia, Adenoma | X |
Pars Intermedia, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + A + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Oviduct | + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + M + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|
| 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Lymphoma Malignant | |
Histiocytic | X |
Femoral, Lymphoma Malignant | |
Lymphocytic | |
Vertebral, Hemangiosarcoma | X |
Vertebral, Lymphoma Malignant | |
Histiocytic | |
Vertebral, Lymphoma Malignant | |
Lymphocytic | |
Vertebral, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + M M + + + + + + + M + + + + + + + + + + + +|
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | X |
Iliac, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant | |
Histiocytic | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Mandibular, Lymphoma Malignant | |
Histiocytic | X |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X X X X X|
Mandibular, Lymphoma Malignant Mixed | X X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X X |
Mediastinal, Lymphoma Malignant Mixed| X X X |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + M M M M + + M M + M M M M + M M M M M + M +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X|
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X X X X|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|
| 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Thymus | M + M + M M + + + + M + M + M M + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + M + + + + + + + + + + + M + + +|
Adenoacanthoma | X |
Adenocarcinoma | |
__________________________________________________________________________|
Skin | + + A + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X X X|
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + A + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + M + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Meningioma Benign | |
__________________________________________________________________________|
Peripheral Nerve | + + M M + + + + + + + + + + + M + + + + + + + +|
Sciatic, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X X |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|
| 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fibrosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinum, Lymphoma Malignant | |
Histiocytic | |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinum, Lymphoma Malignant Mixed| |
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + M + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X|
Adenoma, Multiple | X |
Carcinoma | |
Bilateral, Adenoma | X X X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X X X X|
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3| |
| 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + A A + + + + + + + M + + A + A + + + + +| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A A + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + +| 43 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A A + + + + + + + + + A + + + + + + +| 41 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A A + + + + + + + + + + + + + + + + +| 42 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Adenoma | X X X X X X X X X | 15 |
Hepatocellular Adenoma, Multiple | X | 2 |
Lymphoma Malignant Histiocytic | X X X X | 6 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X X X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + A A + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A A + + + + + + + + + + + + + + + + + +| 44 |
Squamous Cell Papilloma | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A A + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3| |
| 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + +| 34 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Capsule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M M + + M + + + + M M + + M + M + M + + + +| 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + + + M + + + + + + +| 43 |
Pars Distalis, Adenoma | X | 4 |
Pars Intermedia, Adenoma | | 1 |
Pars Intermedia, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Mixed | X | 1 |
Follicular Cell, Adenoma | X| 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + I + + + + + + + + + + + + + + + + +| 47 |
Granulosa Cell Tumor Benign | X X | 5 |
Lymphoma Malignant Histiocytic | X X X | 3 |
Lymphoma Malignant Lymphocytic | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3| |
| 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Femoral, Hemangiosarcoma | | 1 |
Femoral, Lymphoma Malignant | | |
Histiocytic | | 1 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Vertebral, Hemangiosarcoma | | 1 |
Vertebral, Lymphoma Malignant | | |
Histiocytic | X X | 2 |
Vertebral, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Vertebral, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Deep Cervical, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Inguinal, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X X | 3 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | X X | 7 |
Mandibular, Lymphoma Malignant Mixed | X X X X X | 7 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X X | 2 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3| |
| 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Lymphoma Malignant Mixed| X X X | 6 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | X X | 2 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Histiocytic| X X | 2 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
Renal, Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M + M M M M M + M M M M M + + M M M + M M M + M| 13 |
Lymphoma Malignant Histiocytic | X X | 3 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X X X | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | X X X | 5 |
Lymphoma Malignant Lymphocytic | X | 6 |
Lymphoma Malignant Mixed | X X X X X | 8 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + M + M + + + + + + +| 38 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M + + M M M M M + M + + M M + + M + + M + +| 33 |
Adenoacanthoma | | 1 |
Adenocarcinoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Subcutaneous Tissue, Fibrosarcoma | X| 4 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosarcoma, Metastatic, Skin | X X| 2 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3| |
| 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Meningioma Benign | X | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + M + + M + + + + + M + + I + + + + + + + + + +| 42 |
Sciatic, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X X X | 6 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X X X X | 7 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Histiocytic | X X | 4 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
Mediastinum, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinum, Lymphoma Malignant Mixed| X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3| |
| 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X X X X X X X| 12 |
Adenoma, Multiple | | 1 |
Carcinoma | X X | 2 |
Bilateral, Adenoma | X X | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | X X X | 4 |
Lymphoma Malignant Lymphocytic | X | 5 |
Lymphoma Malignant Mixed | X X X | 5 |
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + +| 26 |
__________________________________________________________________________|____________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X X X X | 6 |
Lymphoma Malignant Lymphocytic | X X X | 8 |
Lymphoma Malignant Mixed | X X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|
| 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + + + A + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + M + + + + + + + + + A + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + M + + + + + + + + + M A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + A + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + A + + + + + + A|
Polyp Adenomatous | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + A + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X|
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X X |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Benign | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + M + + M M M M + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M M + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|
| 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Lymphoma Malignant | |
Histiocytic | |
Vertebral, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant | |
Histiocytic | |
Mandibular, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M M M + + + M M M + M + M + M + M M M + M + M M|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|
| 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + M M + + + + + M + + + + + + + + M + + M|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X X X X X X X X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Mediastinum, Lymphoma Malignant | |
Histiocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + M + + + + + + + + + + + + + + + M + + + + + +|
Adenoma | |
Carcinoma | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|
| 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urethra | + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| |
| 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + A + + + + A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + A + + + + + + M + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + M + + + + + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + M + M + + A + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + A + + + + + + + + + +| 45 |
Polyp Adenomatous | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + M + + + + A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + A + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X | 3 |
Hepatocellular Carcinoma, Multiple | X X X | 3 |
Hepatocellular Adenoma | X X | 3 |
Hepatocellular Adenoma, Multiple | X X X | 5 |
Lymphoma Malignant Histiocytic | X X X| 4 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + | 43 |
Lymphoma Malignant Histiocytic | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mast Cell Tumor Benign | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| |
| 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | | 1 |
Bilateral, Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + M + + M M M + M + + + M + + + + M + M| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | M | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Ductus Deferens | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | + + | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + | 29 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Vertebral, Lymphoma Malignant | | |
Histiocytic | X| 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X X | 2 |
Mandibular, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 2 |
Mediastinal, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| |
| 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphocytic | | 1 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M + + M M M M + M M + M + + + + M M M M M + + M| 19 |
Lymphoma Malignant Histiocytic | X X | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X X | 5 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + M + + M M + M + + M M + + M + M + + + M| 36 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibroma | X X | 4 |
Subcutaneous Tissue, Fibrosarcoma | X X X X X | 13 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Multiple | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Skin | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + M + + + + M + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | X| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| |
| 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Lymphoma Malignant Histiocytic | X X | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
Mediastinum, Lymphoma Malignant | | |
Histiocytic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X | 1 |
Carcinoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant Histiocytic | X X | 3 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + + + + + + + + +| 39 |
__________________________________________________________________________|____________|
Urethra | + + + + + + + + + + + + + + + + + +| 30 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X X X X| 6 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|
| 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | A M + + + A + + + A A A |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + A |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + M + + + + + A + A |
__________________________________________________________________________|
Intestine Large, Rectum | M M + M A + + + + A + A |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + A |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + A + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + A |
Adenocarcinoma | |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Hepatocellular Carcinoma | X X X|
Hepatocellular Carcinoma, Multiple | X X X X |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Adenocarcinoma, Metastatic, Stomach | |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
Adenocarcinoma | |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Tongue | M |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + |
Adenocarcinoma, Metastatic, Stomach | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|
| 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + M + M M M + + + I + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M M + M + + |
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + |
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + M + M + + + + + M + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + |
Adenocarcinoma, Metastatic, Stomach | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + |
Femoral, Adenocarcinoma, Metastatic, | |
Stomach | |
Femoral, Lymphoma Malignant | |
Histiocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Lumbar, Lymphoma Malignant Mixed | |
Mandibular, Lymphoma Malignant | |
Histiocytic | |
Mandibular, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M M M + M A + M + + M M + + M M + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Mixed | X |
Mediastinal, Adenocarcinoma, | |
Metastatic, Stomach | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + M |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|
| 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + |
Adenocarcinoma, Metastatic, Stomach | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + |
Meningioma Benign | X |
__________________________________________________________________________|
Peripheral Nerve | + + + M M + + M + + + M M + + + + + + + + + M + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Stomach | |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Fibrosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Bilateral, Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|
| 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Adenocarcinoma, Metastatic, Stomach | |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Ureter | + + + + + + + + |
__________________________________________________________________________|
Urethra | + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6| |
DAY ON TEST | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3| |
| 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Gallbladder | M + + A + + + +| 12 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A A + M + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + A + + M +| 11 |
__________________________________________________________________________|____________|
Intestine Small | A + + A + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + A + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + A + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A M + A + + + + +| 16 |
Adenocarcinoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 2 |
Hepatocellular Carcinoma | X X X X | 7 |
Hepatocellular Carcinoma, Multiple | X X | 6 |
Hepatocellular Adenoma | X X X | 3 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant Histiocytic | X | 2 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 18 |
Adenocarcinoma, Metastatic, Stomach | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + +| 20 |
Adenocarcinoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Tongue | | |
__________________________________________________________________________|____________|
Tooth | + + + + + + + +| 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + +| 19 |
__________________________________________________________________________|____________|
Heart | + + + + + + + +| 20 |
Adenocarcinoma, Metastatic, Stomach | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6| |
DAY ON TEST | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3| |
| 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + +| 20 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M M + + +| 12 |
__________________________________________________________________________|____________|
Pituitary Gland | I + + M + M + + M| 14 |
Pars Distalis, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + +| 20 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + +| 18 |
__________________________________________________________________________|____________|
Ductus Deferens | + + + + +| 16 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 9 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + +| 18 |
__________________________________________________________________________|____________|
Testes | + + + + + + + +| 20 |
Adenocarcinoma, Metastatic, Stomach | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + +| 20 |
Femoral, Adenocarcinoma, Metastatic, | | |
Stomach | X | 1 |
Femoral, Lymphoma Malignant | | |
Histiocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 32 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Mandibular, Lymphoma Malignant | | |
Histiocytic | X | 1 |
Mandibular, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6| |
DAY ON TEST | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3| |
| 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + M + + + M + + +| 17 |
Lymphoma Malignant Histiocytic | X | 3 |
Lymphoma Malignant Mixed | X X | 3 |
Mediastinal, Adenocarcinoma, | | |
Metastatic, Stomach | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + +| 26 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Thymus | M M M + + + M M| 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + +| 33 |
Adenocarcinoma, Metastatic, Stomach | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X X X X X X X X X X X X X| 14 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + +| 34 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + +| 24 |
Fibrosarcoma, Metastatic, Skin | X X X X X X X| 7 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + +| 20 |
Meningioma Benign | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | M + + + M + + + M + + + + + + M + + + + + + + + M| 39 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + +| 20 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma, Metastatic, Stomach | X | 1 |
Alveolar/Bronchiolar Adenoma | X X X X| 6 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6| |
DAY ON TEST | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3| |
| 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Liver | | 2 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + +| 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Adenoma | X X X X X X X X X | 13 |
Bilateral, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + +| 22 |
Adenocarcinoma, Metastatic, Stomach | X | 1 |
Lymphoma Malignant Histiocytic | X | 2 |
__________________________________________________________________________|____________|
Ureter | + + + + + + +| 15 |
__________________________________________________________________________|____________|
Urethra | + | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + +| 21 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 3 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|
DAY ON TEST | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|
| 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Gallbladder | A + A + A + + + A M A + + + A + A + + + + A A + A|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + A + + + A + + + + A + A + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + A + + + + + + + A +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + + + A + + + + A + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + A + + + + A + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + A + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | A + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + A + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + A + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|
DAY ON TEST | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|
| 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Metastatic, Lung | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + A + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + A + + M M M + + M M M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + A + + + + + M + + + + + M + M + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Lymphoma Malignant | |
Lymphocytic | |
Vertebral, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|
DAY ON TEST | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|
| 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Axillary, Fibrosarcoma, Metastatic, | |
Skin | X |
Bronchial, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Mandibular, Lymphoma Malignant Mixed | X |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X X |
Mediastinal, Lymphoma Malignant Mixed| X |
Mediastinal, Mandibular, | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M + + M + M + M + M + M + M M M M + M M + + M M|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + M + + + + + + A M M + + + + + M + + + M + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M M M M M M M M M M M M M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X X X X X X X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|
DAY ON TEST | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|
| 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Fibrosarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Fibrosarcoma, Metastatic, Skin | X X |
Lymphoma Malignant Lymphocytic | X |
Diaphragm, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Carcinoma, Metastatic, Harderian | |
Gland | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Peripheral Nerve | + + + + M M + + + + + + + + + + + M M + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Carcinoma, Metastatic, Harderian | |
Gland | |
Fibrosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|
DAY ON TEST | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|
| 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Adenoma | X X X X X X X X X X X X|
Carcinoma | |
Bilateral, Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3| |
| 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + A + + + + A A A + + + + + M + + + +| 33 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + A + A + + + + + M A + + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + M + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + A + A + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + A + + + + + + + + A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + A + A + + + + + + A + + + + + + + + +| 40 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + A + A + + + M + + A + + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + A + + + + + + + + A + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Hepatocellular Carcinoma | X X X X X X| 10 |
Hepatocellular Carcinoma, Multiple | X | 2 |
Hepatocellular Adenoma | X X X X X X | 13 |
Hepatocellular Adenoma, Multiple | X X X X X | 6 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Squamous Cell Papilloma | X X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3| |
| 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + +| 34 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Capsule, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X | 2 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + M M + + + + + +| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M M + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Ductus Deferens | + + + + + + + + + + + + + + | 28 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Penis | + + + + | 4 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 6 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + | 36 |
Alveolar/Bronchiolar Carcinoma, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3| |
| 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Lymphoma Malignant | | |
Lymphocytic | X X | 2 |
Vertebral, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Fibrosarcoma, Metastatic, | | |
Skin | | 1 |
Bronchial, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mandibular, Lymphoma Malignant Mixed | X| 2 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Mediastinal, Mandibular, | | |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + M M + M M M M M + M + M + + + + + + M + + + +| 24 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X| 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X X | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | X| 2 |
__________________________________________________________________________|____________|
Thymus | M + + M + M + + + + + + + + + + + + + M + + + + M| 39 |
Alveolar/Bronchiolar Carcinoma, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3| |
| 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Metastatic, Lung | X X X | 3 |
Lymphoma Malignant Lymphocytic | X X | 4 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M + M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Adenoma | X | 1 |
Subcutaneous Tissue, Fibroma | X | 3 |
Subcutaneous Tissue, Fibrosarcoma | X X X | 10 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Fibrosarcoma, Metastatic, Skin | X | 3 |
Lymphoma Malignant Lymphocytic | X | 2 |
Diaphragm, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | M + + + + + + + + + + + + + + M + + + + M + + + +| 43 |
__________________________________________________________________________|____________|
Spinal Cord | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X | 10 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3| |
| 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma | X X X X X X X X | 9 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant | | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 4 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X X X X X X X X X X X X X| 27 |
Carcinoma | X X | 2 |
Bilateral, Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 4 |
Lymphoma Malignant Mixed | X| 2 |
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + + + + + + + +| 38 |
__________________________________________________________________________|____________|
Urethra | + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05024-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:53:11
__________________________________________________________________________________________________________________________________
| 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3| |
| 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | X X | 4 |
Lymphoma Malignant Mixed | X| 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
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