TDMS Study 05024-02 Pathology Tables
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
Facility: Battelle Columbus Laboratory
Chemical CAS #: 924-42-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + A + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + M + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Inflammation, Chronic Active | 1 4 |
Leukocytosis | X |
Vacuolization Cytoplasmic | 2 |
Artery, Necrosis, Fibrinoid | 4 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + M M M + M + + M M M + + + + M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + M + +|
Inflammation, Chronic Active | 1 |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 2 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X X X|
Inflammation, Suppurative | |
Mineralization | 2 |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Thrombosis | X |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 3 3 3 2 2 3 4 4 2 3 2 2 3 3 4 4 2 1 2 4 2|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 2 |
Femoral, Myelofibrosis | 2 2 |
Vertebral, Myelofibrosis | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + M M + + M M M + A M M M M M M M + M M M M M|
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hematopoietic Cell Proliferation | 4 3 4 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 9| 3| 3| 3| 9| 3| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 1| 5| 3| 1| 3| 0| 3| 3| 1| 0| 1| 6| 1| 2| 3| 5| 3| 2| 2| 3| 2| 1| 2| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M + M + + + + + M + + M M + + M M M M M|
Hyperplasia, Cystic | 2 1 1 2 1 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Inflammation, Chronic Active | 4 |
Artery, Necrosis, Fibrinoid | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Peripheral Nerve | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
White Matter, Degeneration | 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 1 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 2 |
Nephropathy, Chronic | 4 1 1 |
__________________________________________________________________________|
Ureter | + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| |
| 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + M + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + A| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Inflammation, Chronic Active | | 2 2.5|
Leukocytosis | | 1 |
Vacuolization Cytoplasmic | | 1 2.0|
Artery, Necrosis, Fibrinoid | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Chronic Active | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 3 3 4 | 3 3.3|
Duct, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + A| 46 |
Acanthosis | 3 3 | 3 3.0|
Hyperkeratosis | 4 | 1 4.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A| 47 |
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| |
| 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M M + + M + + M M + + M + M + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 2 2 1 2 2 | 22 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 | 2 1.5|
C-Cell, Hyperplasia | 2 | 1 2.0|
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | 2 2 2 2 2 | 9 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 3 | 3 3.3|
Cyst | X X X X X X X | 10 |
Inflammation, Suppurative | 4 | 1 4.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
Thrombosis | | 1 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 1 3 2 3 3 2 2 2 2 4 2 2 3 2 2 2 2 3 4 4 3 3 2 3 | 47 2.6|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia, Reticulum Cell | | 1 2.0|
Femoral, Myelofibrosis | 1 | 3 1.7|
Vertebral, Myelofibrosis | 2 2 2 3 1 2 2 1 2 2 2 2 1 | 29 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| |
| 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumbar, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M + M M M M M M M + + M M + M M M M M M M + M M| 11 |
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 4 4 3 2 2 4 2 3 3 3 2| 15 3.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + M + + + M + + + + + M M + M M + + +| 29 |
Hyperplasia, Cystic | 1 1 1 1 1 2 1 2 1 2 1 2 1 1 2| 20 1.4|
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | 4| 1 4.0|
Inflammation, Chronic Active | 3 | 2 3.5|
Artery, Necrosis, Fibrinoid | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + M + + + + + + + + + + + M| 47 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
White Matter, Degeneration | 2 2 2 | 5 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 2 2 2 2 | 12 1.8|
Alveolar Epithelium, Hyperplasia | 1 2 2 2 2 | 8 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| |
| 3| 2| 2| 1| 3| 1| 1| 2| 1| 2| 4| 4| 1| 2| 2| 1| 2| 1| 2| 1| 2| 1| 3| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | M + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Osseous | 2 | 2 2.0|
Nephropathy, Chronic | 1 1 1 1 1 1 1 | 10 1.3|
__________________________________________________________________________|____________|
Ureter | + + + M + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + A| 43 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|
| 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + |
__________________________________________________________________________|
Gallbladder | A + |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | M + + |
__________________________________________________________________________|
Intestine Large, Colon | + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + |
__________________________________________________________________________|
Intestine Small | + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | M + |
__________________________________________________________________________|
Intestine Small, Jejunum | M + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Atypia Cellular | |
Degeneration, Cystic | 2 |
Hematopoietic Cell Proliferation | 2 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 |
Leukocytosis | X X |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach | + + |
__________________________________________________________________________|
Stomach, Forestomach | + + |
__________________________________________________________________________|
Stomach, Glandular | A + |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + |
__________________________________________________________________________|
Islets, Pancreatic | + + |
__________________________________________________________________________|
Parathyroid Gland | M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + +|
Pars Distalis, Hyperplasia | 2 2|
__________________________________________________________________________|
Thyroid Gland | + + |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|
| 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + + + + + + I + + I + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3|
Cyst | X X X X X |
__________________________________________________________________________|
Oviduct | + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Hemorrhage | 2 2 |
Artery, Hyperplasia, Cystic, | |
Glandular | 2 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 3 2 4 3 4 2 2 2 1 2 3 2 2 2 2|
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + |
Femoral, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Mandibular, Hematopoietic Cell | |
Proliferation | |
Renal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + |
Hematopoietic Cell Proliferation | 3 2 3 3 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | M M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 3 2 1 1 1 1 2 2 1 1 1 1 1 1 2 1 1 2 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + |
Abscess | |
Alopecia | |
Foreign Body | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 8| 3| 0| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 9| 3|
| 2| 3| 1| 1| 2| 8| 1| 5| 3| 9| 6| 2| 1| 3| 2| 1| 2| 1| 3| 1| 3| 1| 2| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
__________________________________________________________________________|
Peripheral Nerve | + + + + + I I + + + + + + + + + + + + + + + + + I|
Sciatic, Degeneration | 2 2 2 |
__________________________________________________________________________|
Spinal Cord | + + |
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3 |
Inflammation, Chronic | 2 3 2 2 2 1 2 2 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 3 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + |
__________________________________________________________________________|
Trachea | + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + M + M + + + + + + + M + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + |
Amyloid Deposition | |
Atrophy | 4 |
Inflammation | 4 |
Nephropathy, Chronic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 6 |
__________________________________________________________________________|____________|
Gallbladder | + A + + | 4 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + | 5 |
Inflammation, Chronic Active | 4 | 1 4.0|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + | 4 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 4 | 1 4.0|
Atypia Cellular | X X | 2 |
Degeneration, Cystic | | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 | 4 2.3|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Leukocytosis | | 2 |
Necrosis, Coagulative | 3 1 2 | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 6 |
Acinus, Atrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 7 |
__________________________________________________________________________|____________|
Stomach | + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 5 |
__________________________________________________________________________|____________|
Tooth | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 6 |
__________________________________________________________________________|____________|
Heart | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 7 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 6 |
Hematopoietic Cell Proliferation | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 6 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 14 |
Pars Distalis, Hyperplasia | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + M + + + + I M +| 45 |
Atrophy | 3 3 3 3 3 3 3 3 3 3 4 3 4 3 3 3 3 3 3 3| 39 3.0|
Cyst | X X X X | 9 |
__________________________________________________________________________|____________|
Oviduct | + + + + | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 35 |
Dilatation | 4 | 2 4.0|
Hemorrhage | 2 3 2 | 5 2.2|
Artery, Hyperplasia, Cystic, | | |
Glandular | | 1 2.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 2 2 2 3 3 2 3 2 2 4 2 3 3 3 | 31 2.5|
__________________________________________________________________________|____________|
Vagina | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
Neutrophilia | X X | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 6 |
Femoral, Hyperplasia | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 13 |
Mandibular, Hematopoietic Cell | | |
Proliferation | 3 2 | 2 2.5|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + M + M + | 7 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + +| 19 |
Hematopoietic Cell Proliferation | 4 3 3 3 3 | 10 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | M + M + + + | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + M +| 48 |
Hyperplasia, Cystic | 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1| 40 1.3|
__________________________________________________________________________|____________|
Skin | + + + + + + | 14 |
Abscess | 4 | 1 4.0|
Alopecia | X | 1 |
Foreign Body | 4 | 1 4.0|
Inflammation, Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 6 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 7 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + M + + + + + M + + + + M + M| 43 |
Sciatic, Degeneration | 2 | 4 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + | 6 |
White Matter, Degeneration | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | | 1 3.0|
Inflammation, Chronic | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 28 2.0|
Alveolar Epithelium, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 26 2.0|
__________________________________________________________________________|____________|
Nose | + + + + | 6 |
__________________________________________________________________________|____________|
Trachea | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + I + + + + + + + + + + + + M + + + + + + + + +| 45 |
Hyperplasia | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 11 |
Amyloid Deposition | 3 | 1 3.0|
Atrophy | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 7| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 3| 1| 3| 3| 3| 4| 1| 9| 3| 3| 7| 3| 3| 3| 4| 3| 3| 3| 9| 3| |
| 2| 2| 3| 3| 2| 3| 8| 1| 1| 3| 8| 0| 2| 1| 3| 5| 2| 1| 1| 7| 1| 3| 2| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation | | 1 4.0|
Nephropathy, Chronic | 3 1 | 3 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + M + + + | 6 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|
| 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A A + + + + M + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large | + + A A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + +|
Infarct | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + A A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + A|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + A|
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | |
Hematopoietic Cell Proliferation | |
Leukocytosis | |
Necrosis, Coagulative | 3 |
Pigmentation, Hematoidin | |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Cyst | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Necrosis | 4 |
Thrombosis | X |
__________________________________________________________________________|
Pancreas | + + A A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Acinus, Atrophy | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + A A + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + A A + + + + + + + + + + + + + + + + + + + A|
Acanthosis | 3 2 3 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + A A + + + + + + + + + + + + + + + + + + + A|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 2 2 3 |
Foreign Body | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|
| 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 |
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + M + + + + + + + + + + +|
Corticomedullary Junction, | |
Degeneration, Fatty | 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cyst | X |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + A A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M M + M + M + + M M + + + + M M + + M M + + M M|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + M + + + M + + + + + + + M + + + + + + M + +|
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 2 1 3 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + A + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 3 2 3 2 2 3 2 3 2 2 2 2 2 3 2 2|
Cyst | X X X X |
Hemorrhage, Acute | 4 |
Inflammation, Suppurative | |
Mineralization | |
Thrombosis | |
__________________________________________________________________________|
Oviduct | + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|
| 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Dilatation | 3 4 |
Hemorrhage | 3 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 2 2 2 2 2 2 2 2 2 4 2 1 2 2 2 1 2 1 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + M + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | |
Femoral, Myelofibrosis | 2 |
Vertebral, Hyperplasia | |
Vertebral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + M M + + + + + + + M + + + + + + + + + + + +|
Iliac, Thrombosis | X |
Mandibular, Hematopoietic Cell | |
Proliferation | |
Mandibular, Hyperplasia, Plasma Cell | 2 |
Mandibular, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Thrombosis | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + M M M M + + M M + M M M M + M M M M M + M +|
Angiectasis | 2 2 |
Hyperplasia, Plasma Cell | 2 |
Thrombosis | X |
__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 2 3 1 3 3 1 1 4 3 2 2 1 3 3 3|
Infarct | |
__________________________________________________________________________|
Thymus | M + M + M M + + + + M + M + M M + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + M + + + + + + + + + + + M + + +|
Hyperplasia, Cystic | 1 1 1 1 1 2 1 1 1 1 1 2 1 2 1 1 1 2|
__________________________________________________________________________|
Skin | + + A + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + A + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 5| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 4| 3| 3| 3| 3| 3| 3| 2| 3| 7|
| 2| 3| 7| 3| 3| 2| 3| 5| 2| 1| 2| 2| 3| 3| 9| 7| 1| 2| 3| 3| 3| 1| 9| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Peripheral Nerve | + + M M + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Inflammation, Chronic | 1 1 3 2 2 3|
Pigmentation, Hemosiderin | 2 1 |
Alveolar Epithelium, Hyperplasia | 1 2 3 2 1 2 2 2|
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Nasolacrimal Duct, Foreign Body | 1 |
Nasolacrimal Duct, Granuloma | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 4 |
Retina, Atrophy | 3 3 |
__________________________________________________________________________|
Harderian Gland | + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct | 3 |
Metaplasia, Osseous | 2 |
Mineralization | |
Necrosis | |
Nephropathy, Chronic | 1 2 1 1 3 1 1 2 2 1 2 2 2 2 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3| |
| 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + A A + + + + + + + M + + A + A + + + + +| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A A + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + +| 44 |
Infarct | 4 | 1 4.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + +| 43 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A A + + + + + + + + + A + + + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + +| 43 |
Inflammation, Necrotizing | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A A + + + + + + + + + + + + + + + + +| 42 |
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Clear Cell Focus | X X | 2 |
Hematopoietic Cell Proliferation | 2 3 | 2 2.5|
Leukocytosis | X | 1 |
Necrosis, Coagulative | 3 2 | 3 2.7|
Pigmentation, Hematoidin | 1 | 1 1.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 | 2 2.0|
Bile Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | | 1 4.0|
Necrosis | 3 | 2 3.5|
Thrombosis | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | 2 | 2 3.0|
Acinus, Atrophy | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach | + + + + + A A + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A A + + + + + + + + + + + + + + + + + +| 44 |
Acanthosis | 3 3| 5 2.8|
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A A + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3| |
| 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Dysplasia | | 3 2.3|
Foreign Body | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + +| 34 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy, Chronic | 2 3 | 4 2.3|
Inflammation, Chronic Active | 2 3 | 2 2.5|
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Corticomedullary Junction, | | |
Degeneration, Fatty | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Accessory Adrenal Cortical Nodule | X X X | 3 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M M + + M + + + + M M + + M + M + M + + + +| 28 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + + + M + + + + + + +| 43 |
Pars Distalis, Hyperplasia | 2 2 3 2 2 1 1 1 2 1| 13 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 2.0|
C-Cell, Hyperplasia | 3 | 1 3.0|
Follicle, Cyst | X X X | 3 |
Follicular Cell, Hyperplasia | 3 2 3 | 11 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3| |
| 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + I + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 3 2 2 2 4 3 3 3 2 3 2 2 3 3 2 2 3 3 3| 38 2.5|
Cyst | X X | 6 |
Hemorrhage, Acute | 4 | 2 4.0|
Inflammation, Suppurative | 2 | 1 2.0|
Mineralization | 2 | 1 2.0|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 4 | 4 3.5|
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 2 2 | 2 2.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 1 1 2 2 3 2 2 2 4 2 1 3 1 2 2 3 1 1 2 2 2 2 2 3| 45 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Femoral, Hyperplasia | 4 | 1 4.0|
Femoral, Myelofibrosis | | 1 2.0|
Vertebral, Hyperplasia | 4 | 1 4.0|
Vertebral, Myelofibrosis | 2 2 2 1 1 1 1 2 2 | 10 1.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Iliac, Thrombosis | | 1 |
Mandibular, Hematopoietic Cell | | |
Proliferation | 4 | 1 4.0|
Mandibular, Hyperplasia, Plasma Cell | 2 2| 3 2.0|
Mandibular, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Renal, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M + M M M M M + M M M M M + + M M M + M M M + M| 13 |
Angiectasis | 2 | 3 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 1 2 2 2 2 4 2 2 3 3 1 3 1 2 2 4 4 2 4 2 3| 40 2.4|
Infarct | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + M + M + + + + + + +| 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3| |
| 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M + + M M M M M + M + + M M + + M + + M + +| 33 |
Hyperplasia, Cystic | 2 1 1 1 1 1 1 2 1 1 2| 29 1.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosis, Focal | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + M + + M + + + + + M + + I + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
White Matter, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage, Acute | 2 | 1 2.0|
Inflammation, Chronic | 2 2 1 2 2 2 1 2 | 14 1.9|
Pigmentation, Hemosiderin | 2 | 3 1.7|
Alveolar Epithelium, Hyperplasia | 2 2 1 2 2 2 2 2 2 | 17 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 | 1 2.0|
Nasolacrimal Duct, Foreign Body | | 1 1.0|
Nasolacrimal Duct, Granuloma | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 1 | 5 1.4|
__________________________________________________________________________|____________|
Trachea | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 2 3.5|
Retina, Atrophy | | 2 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 3| 3| 8| 6| 3| 2| 3| 3| 3| 3| 3| 3| 1| 3| 2| 3| 2| 7| 3| 5| 3| 3| |
| 3| 3| 7| 1| 3| 0| 7| 2| 3| 3| 2| 3| 1| 2| 3| 1| 1| 8| 2| 9| 4| 2| 3| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hydronephrosis | 3 | 1 3.0|
Infarct | 2 2 4 2 | 5 2.6|
Metaplasia, Osseous | 2 2 | 3 2.0|
Mineralization | 2 | 1 2.0|
Necrosis | 4 | 1 4.0|
Nephropathy, Chronic | 2 2 1 1 1 2 1 2 1| 23 1.6|
Renal Tubule, Regeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + +| 26 |
__________________________________________________________________________|____________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|
| 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + + + A + A|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + M + + + + + + + + + A + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + M + + + + + + + + + M A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + A + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + A + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + A + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hemorrhage | 4 |
Hepatodiaphragmatic Nodule | X |
Leukocytosis | X X |
Mineralization | 2 |
Necrosis, Coagulative | 4 1 |
Pigmentation, Hematoidin | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 1 1 2 2 1 1 2 1 2|
Hyperkeratosis | 3 2 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 4 |
Inflammation, Chronic Active | 4 4 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic Active | |
Mesenteric Artery, Necrosis, | |
Fibrinoid | |
Pulmonary Artery, Inflammation, | |
Chronic Active | |
Pulmonary Artery, Necrosis, Fibrinoid| |
Renal Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|
| 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Active | |
Renal Artery, Necrosis, Fibrinoid | |
Renal Artery, Thrombosis | |
Thoracic, Inflammation, Chronic | |
Active | |
Thoracic, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Atrium, Thrombosis | |
Coronary Artery, Inflammation, | |
Chronic Active | |
Coronary Artery, Necrosis, Fibrinoid | |
Valve, Bacterium | X |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | |
Hypertrophy | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + M + + M M M M + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M M + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Necrosis, Fibrinoid | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
Mineralization | 3 |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|
| 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + +|
Dilatation | 4 4 |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Neutrophilia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 4 4 |
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | 3 |
Mandibular, Hyperplasia, Plasma Cell | 4 |
Mandibular, Inflammation, Suppurative| 2 |
Mandibular, Necrosis | |
Mediastinal, Inflammation, | |
Suppurative | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M M M + + + M M M + M + M + M + M M M + M + M M|
Angiectasis | 2 3 2 1 |
Hematopoietic Cell Proliferation | 2 4 3 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 4 4 4 4 4|
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + M M + + + + + M + + + + + + + + M + + M|
Cyst | X |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Alopecia | |
Fibrosis | 3 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|
| 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Necrosis, Coagulative | |
Lymphatic, Ectasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Femur, Tibia, Metaplasia, | |
Osseous | 4 |
Joint, Tarsal, Metaplasia, Osseous | 4 4 4 4 4 4 4 4 4 4 4 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Inflammation, Chronic Active | |
Artery, Cerebrum, Necrosis, Fibrinoid| |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + M + + + + + +|
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 2 |
Inflammation, Chronic | 2 2 2 2 |
Leukocytosis | X |
Alveolar Epithelium, Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + M + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hydronephrosis | |
Infarct | 3 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 6| 4| 2| 1| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 8| 2| 3| 2| 2| 1| 6| 2| 0| 3| 3| 8| 3| 3|
| 2| 2| 2| 2| 1| 1| 3| 2| 2| 2| 1| 4| 4| 1| 8| 9| 7| 7| 0| 3| 2| 3| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy, Chronic | 1 1 1 1 1 1 3 2 1 1 |
Artery, Inflammation, Chronic Active | |
Artery, Necrosis, Fibrinoid | |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Urethra | + + + + + + + + + + + + |
Concretion | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| |
| 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + A + + + + A + + + + + + + + + +| 44 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + A + + + + + + M + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + M + + + + + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + M + M + + A + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + M + + + + A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + A + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Hemorrhage | | 1 4.0|
Hepatodiaphragmatic Nodule | X | 2 |
Leukocytosis | | 2 |
Mineralization | | 1 2.0|
Necrosis, Coagulative | 2 3 4 | 5 2.8|
Pigmentation, Hematoidin | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + | 43 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 2 1 2 1 2 1 2 | 20 1.6|
Hyperkeratosis | 2 | 4 2.5|
Inflammation, Chronic Active | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia | 3 | 2 3.5|
Inflammation, Chronic Active | 2 | 4 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Mesenteric Artery, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
Mesenteric Artery, Necrosis, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| |
| 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Fibrinoid | 4 | 1 4.0|
Pulmonary Artery, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
Pulmonary Artery, Necrosis, Fibrinoid| 3 | 1 3.0|
Renal Artery, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
Renal Artery, Necrosis, Fibrinoid | 4 | 1 4.0|
Renal Artery, Thrombosis | X | 1 |
Thoracic, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Thoracic, Necrosis, Fibrinoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
Atrium, Thrombosis | X | 1 |
Coronary Artery, Inflammation, | | |
Chronic Active | 3 | 1 3.0|
Coronary Artery, Necrosis, Fibrinoid | 3 | 1 3.0|
Valve, Bacterium | | 1 |
Valve, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Accessory Adrenal Cortical Nodule | | 1 |
Hyperplasia | 2 2 | 2 2.0|
Hypertrophy | 2 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + M + + M M M + M + + + M + + + + M + M| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
Necrosis, Fibrinoid | 3 | 1 3.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| |
| 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | M | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Ductus Deferens | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | + + | 3 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 3 |
Inflammation, Chronic Active | 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 4 4 3| 4 3.3|
Artery, Necrosis, Fibrinoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + | 29 |
Dilatation | 4 3 3 | 5 3.6|
Inflammation, Chronic Active | 2 2 | 2 2.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 3 | 1 3.0|
Seminiferous Tubule, Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 3 |
Neutrophilia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia | | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mandibular, Hyperplasia, Lymphoid | | 1 3.0|
Mandibular, Hyperplasia, Plasma Cell | | 1 4.0|
Mandibular, Inflammation, Suppurative| | 1 2.0|
Mandibular, Necrosis | 2 | 1 2.0|
Mediastinal, Inflammation, | | |
Suppurative | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M + + M M M M + M M + M + + + + M M M M M + + M| 19 |
Angiectasis | 2 2 2 3 2 2 | 10 2.1|
Hematopoietic Cell Proliferation | 1 3 4 3 2 3 2 | 11 2.6|
Hyperplasia, Lymphoid | 4 | 1 4.0|
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| |
| 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | 3 2 | 2 2.5|
Hematopoietic Cell Proliferation | 4 3 3 2 4 3| 11 3.5|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + M M + M + + M M + + M + M + + + M| 36 |
Cyst | X X | 3 |
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 2 | 3 2.3|
Alopecia | X | 1 |
Fibrosis | | 1 3.0|
Hyperkeratosis | 2 | 2 2.0|
Inflammation, Chronic Active | 3 2 3 3 4 4 | 7 3.3|
Inflammation, Suppurative | 2 | 1 2.0|
Necrosis, Coagulative | 4 | 1 4.0|
Lymphatic, Ectasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Joint, Femur, Tibia, Metaplasia, | | |
Osseous | | 1 4.0|
Joint, Tarsal, Metaplasia, Osseous | 4 4 4 4 4 4 4 4 4 4 4 4 4 | 24 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Artery, Cerebrum, Necrosis, Fibrinoid| 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + M + + + + M + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
White Matter, Degeneration | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage, Acute | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 7| 6| 5| 1| 6| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| |
DAY ON TEST | 3| 3| 3| 3| 9| 6| 3| 7| 8| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 8| 3| 3| 3| |
| 2| 1| 1| 3| 7| 4| 3| 3| 9| 2| 5| 1| 2| 2| 8| 3| 3| 3| 2| 9| 2| 3| 3| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 3 2 2 | 8 2.1|
Leukocytosis | | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 3 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Hydronephrosis | 3 | 1 3.0|
Infarct | 3 | 2 3.0|
Inflammation, Suppurative | 2 2 | 3 2.3|
Nephropathy, Chronic | 1 1 1 1 1 1 3 1 4 1 1 | 21 1.4|
Artery, Inflammation, Chronic Active | 3 3 | 2 3.0|
Artery, Necrosis, Fibrinoid | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + + + + + + + + +| 39 |
Inflammation, Chronic Active | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + + + + + + + + + + + + + + + + + +| 30 |
Concretion | 2 4 | 2 3.0|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Dilatation | 2 3 2| 3 2.3|
Inflammation, Chronic Active | 2 4 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|
| 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | A M + + + A + + + A A A |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + A |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + M + + + + + A + A |
__________________________________________________________________________|
Intestine Large, Rectum | M M + M A + + + + A + A |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + A |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + A + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Necrotizing | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + |
Cyst | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 2 2 2 2 1 1 2 1 3 2 2|
Hyperkeratosis | 1 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
Cyst | |
__________________________________________________________________________|
Tongue | M |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + |
Valve, Bacterium | X |
Valve, Inflammation, Suppurative | 3 |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + |
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|
| 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + |
__________________________________________________________________________|
Parathyroid Gland | + M + M M M + + + I + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M M + M + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + |
Ultimobranchial Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Penis | + + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Inflammation, Chronic Active | |
Duct, Ectasia | 3 |
Lymphatic, Ectasia | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + |
Inflammation, Chronic Active | 4 4 1 |
__________________________________________________________________________|
Seminal Vesicle | + M + M + + + + + M + + + + |
Dilatation | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + |
Mineralization | 1 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + |
Femoral, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Lumbar, Hyperplasia, Plasma Cell | 3 |
Mandibular, Hematopoietic Cell | |
Proliferation | 3 |
Mandibular, Hyperplasia | |
Renal, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M M M + M A + M + + M M + + M M + +|
Angiectasis | 2 4 2 2|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|
| 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 3 3 3 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 4 4 4 3 |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + M |
Necrosis | 3 4 4 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + |
Abscess | 3 3 |
Inflammation, Chronic Active | 4 4 3 3 3 4 |
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | |
Prepuce, Concretion | 4 |
Prepuce, Dilatation | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
Joint, Femur, Tibia, Metaplasia, | |
Osseous | |
Joint, Tarsal, Metaplasia, Osseous | 3 3 4 3 3 4 3 4 |
Sternum, Developmental Malformation | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + |
__________________________________________________________________________|
Peripheral Nerve | + + + M M + + M + + + M M + + + + + + + + + M + +|
Sciatic, Degeneration | 2 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Leukocytosis | X |
Alveolar Epithelium, Hyperplasia | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + |
Foreign Body | 2 |
Granuloma | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 7| 6| 1| 1| 1| 0| 7| 7| 2| 1| 7| 1| 6| 7| 6| 5| 7| 4| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 0| 8| 3| 1| 1| 5| 3| 3| 0| 2| 3| 6| 0| 2| 8| 0| 3| 1| 3| 3| 6| 1| 3| 3| 3|
| 8| 7| 5| 7| 2| 0| 1| 2| 1| 6| 2| 5| 0| 7| 6| 2| 1| 5| 1| 3| 0| 1| 3| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + |
Bacterium | X |
Hydronephrosis | 3 |
Infarct | 2 3 |
Inflammation, Suppurative | 4 1 2 |
Mineralization | 2 1 |
Nephropathy, Chronic | 1 1 2 |
__________________________________________________________________________|
Ureter | + + + + + + + + |
__________________________________________________________________________|
Urethra | + + + + + + + |
Concretion | 4 4 4 |
Inflammation, Chronic Active | 4 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + +|
Dilatation | 3 3 3 3 2|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6| |
DAY ON TEST | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3| |
| 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Gallbladder | M + + A + + + +| 12 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A A + M + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + A + + M +| 11 |
__________________________________________________________________________|____________|
Intestine Small | A + + A + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + A + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + A + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A M + A + + + + +| 16 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Inflammation, Necrotizing | 2 | 1 2.0|
Necrosis, Coagulative | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + +| 21 |
Cyst | X | 1 |
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + +| 20 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 1 1 2 2 2 2 1 1 2| 23 1.7|
Hyperkeratosis | | 1 1.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + +| 20 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Tongue | | |
__________________________________________________________________________|____________|
Tooth | + + + + + + + +| 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + +| 19 |
__________________________________________________________________________|____________|
Heart | + + + + + + + +| 20 |
Valve, Bacterium | X | 2 |
Valve, Inflammation, Suppurative | 4 | 2 3.5|
Valve, Thrombosis | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6| |
DAY ON TEST | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3| |
| 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + +| 21 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + +| 20 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M M + + +| 12 |
__________________________________________________________________________|____________|
Pituitary Gland | I + + M + M + + M| 14 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + +| 20 |
Ultimobranchial Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + +| 18 |
__________________________________________________________________________|____________|
Ductus Deferens | + + + + +| 16 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + +| 20 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 2 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 9 |
Inflammation, Chronic Active | 4 | 1 4.0|
Duct, Ectasia | | 1 3.0|
Lymphatic, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + +| 20 |
Inflammation, Chronic Active | | 3 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + +| 18 |
Dilatation | 4 | 1 4.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + +| 20 |
Mineralization | | 1 1.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 2 |
Neutrophilia | X X | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + +| 20 |
Femoral, Hyperplasia | 4 4 | 3 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6| |
DAY ON TEST | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3| |
| 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 32 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Mandibular, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Mandibular, Hyperplasia | 2 | 1 2.0|
Renal, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + M + + + M + + +| 17 |
Angiectasis | 2 2 3 2 3 4| 10 2.6|
Hematopoietic Cell Proliferation | 2 2 3 3 2 2| 11 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + +| 26 |
Hematopoietic Cell Proliferation | 3 4 3 3 3 4 4 3 | 13 3.5|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M M M + + + M M| 13 |
Necrosis | 4 | 6 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + +| 33 |
Abscess | | 2 3.0|
Inflammation, Chronic Active | 4 2 2 | 9 3.2|
Inflammation, Suppurative | | 1 2.0|
Metaplasia, Osseous | 3 | 1 3.0|
Prepuce, Concretion | | 1 4.0|
Prepuce, Dilatation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + +| 34 |
Joint, Femur, Tibia, Metaplasia, | | |
Osseous | 3 | 1 3.0|
Joint, Tarsal, Metaplasia, Osseous | 4 4 4 2 4 4 4 4 | 16 3.6|
Sternum, Developmental Malformation | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + +| 24 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Peripheral Nerve | M + + + M + + + M + + + + + + M + + + + + + + + M| 39 |
Sciatic, Degeneration | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 6| 6| 7| 7| 4| 2| 7| 7| 7| 7| 6| 7| 4| 7| 7| 6| 7| 7| 5| 7| 6| |
DAY ON TEST | 8| 8| 9| 8| 1| 5| 3| 3| 3| 2| 3| 3| 3| 3| 9| 1| 5| 3| 3| 3| 3| 3| 0| 3| 3| |
| 3| 4| 0| 5| 7| 2| 1| 2| 2| 1| 2| 1| 1| 3| 1| 1| 5| 1| 3| 4| 2| 1| 1| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
25 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + +| 20 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 3 2 2 1 2 1 1 2 | 12 1.8|
Leukocytosis | | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 2 2 2 2 2 1 1 2 | 17 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + +| 20 |
Foreign Body | | 1 2.0|
Granuloma | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + +| 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Lens, Cataract | 3 3 | 2 3.0|
Retina, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + +| 22 |
Bacterium | | 1 |
Hydronephrosis | | 1 3.0|
Infarct | 4 | 3 3.0|
Inflammation, Suppurative | | 3 2.3|
Mineralization | 1 | 3 1.3|
Nephropathy, Chronic | 2 | 4 1.5|
__________________________________________________________________________|____________|
Ureter | + + + + + + +| 15 |
__________________________________________________________________________|____________|
Urethra | + | 8 |
Concretion | 3 | 4 3.8|
Inflammation, Chronic Active | | 2 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + +| 21 |
Dilatation | 4 4 3 | 8 3.1|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|
DAY ON TEST | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|
| 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Gallbladder | A + A + A + + + A M A + + + A + A + + + + A A + A|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + A + + + A + + + + A + A + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + A + + + + + + + A + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + A + + + + + + + A + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + A + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + + + A + + + + A + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + A + + + + A + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | 3 |
Leukocytosis | X X |
Necrosis, Coagulative | 2 2 3 3 2 3|
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + A + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | |
__________________________________________________________________________|
Stomach | A + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + A + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 2 1 2 2 1 4 1 4 1 1|
Acanthosis, Multiple | |
Hyperkeratosis | 3 1 1 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + A + + + + A + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 4 4 4 3 |
Foreign Body | 1 |
Inflammation, Chronic Active | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|
DAY ON TEST | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|
| 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 3|
Valve, Bacterium | X X X X|
Valve, Thrombosis | X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X |
Hyperplasia | 2 |
Hypertrophy | 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + A + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + A + + M M M + + M M M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + A + + + + + M + + + + + M + M + M|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + |
Inflammation, Chronic Active | 4 |
Lymphatic, Ectasia | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 4 4 4 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|
DAY ON TEST | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|
| 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hemorrhage, Acute | 3 |
Axillary, Hyperplasia, Lymphoid | 3 |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M + + M + M + M + M + M + M M M M + M M + + M M|
Angiectasis | 3 2 2 4 2 2 |
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 3 3 3 2 2 3 3 2 4 2 2 3 2 4 3 3|
Infarct | 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + A M M + + + + + M + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M M M M M M M M M M M M M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Edema | 3 |
Fibrosis | 3 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 3 3 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Metaplasia, Osseous | 4 4 4 4 4 4 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + M M + + + + + + + + + + + M M + + + + + +|
Sciatic, Degeneration | 2 1 1 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
White Matter, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3 |
Inflammation, Chronic | 2 2 2 1 1 2 3 2 2 3 |
Leukocytosis | X |
Alveolar Epithelium, Hyperplasia | 2 2 2 1 2 2 3 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 3| 5| 7| 6| 4| 5| 6| 7| 6| 7| 5| 4| 5| 7| 7| 6| 7| 6| 5| 7| 4|
DAY ON TEST | 4| 4| 2| 3| 6| 0| 3| 9| 7| 0| 5| 3| 9| 3| 4| 7| 8| 3| 3| 6| 3| 2| 6| 3| 8|
| 4| 5| 9| 1| 6| 1| 3| 0| 8| 2| 4| 3| 1| 1| 8| 6| 2| 3| 3| 7| 3| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic Active | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Infarct | 3 4 4 3 3 |
Inflammation, Suppurative | 3 |
Mineralization | 2 2 2 |
Nephropathy, Chronic | 1 1 3 1 1 2 2 2 2 |
Thrombosis | |
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
Dilatation | 3 4 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3| |
| 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + A + + + + A A A + + + + + M + + + +| 33 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + A + A + + + + + M A + + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + M + + + + + + + + + + + + + + + +| 43 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + A + A + + + + + + + + + + + + + + + +| 42 |
Parasite Metazoan | X| 1 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + A + + + + + + + + A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + A + A + + + + + + A + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + A + A + + + M + + A + + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + A + + + + + + + + A + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | | 1 |
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Leukocytosis | X | 3 |
Necrosis, Coagulative | 2 3 | 8 2.5|
Vacuolization Cytoplasmic | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 2 | 3 2.3|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic Active | | 1 2.0|
Necrosis, Coagulative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis, Coagulative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acanthosis | 1 2 2 1 1 1 1 1 2 3 1 2 2 1| 26 1.7|
Acanthosis, Multiple | 4 | 1 4.0|
Hyperkeratosis | 3 3 1 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 45 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia | 3 3 2 4 | 8 3.4|
Foreign Body | | 1 1.0|
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3| |
| 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + +| 34 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 2 | 4 2.0|
Inflammation, Suppurative | | 2 2.5|
Valve, Bacterium | | 4 |
Valve, Thrombosis | X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Accessory Adrenal Cortical Nodule | | 2 |
Hyperplasia | | 1 2.0|
Hypertrophy | 2 3 | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 | 5 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + M M + + + + + +| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M M + + + + + + + + + +| 42 |
Pars Distalis, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 1 1 2 2 | 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Dilatation | 4 | 2 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ductus Deferens | + + + + + + + + + + + + + + | 28 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | + + + + | 4 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 6 |
Inflammation, Chronic Active | 3 3 2 | 4 3.0|
Lymphatic, Ectasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3| |
| 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + | 36 |
Dilatation | 2 2 | 4 3.0|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia | 4 4 4 | 6 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Hemorrhage, Acute | | 1 3.0|
Axillary, Hyperplasia, Lymphoid | | 1 3.0|
Mandibular, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mandibular, Hyperplasia, Plasma Cell | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + M M + M M M M M + M + M + + + + + + M + + + +| 24 |
Angiectasis | 3 3 3 3 2 2 4 2 | 14 2.6|
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 3 4 | 10 2.5|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 2 3 2 2 3 2 2 3 3 3 2 2 4 3 2 4 2 3| 38 2.7|
Infarct | 4 | 2 3.5|
__________________________________________________________________________|____________|
Thymus | M + + M + M + + + + + + + + + + + + + M + + + + M| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M + M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 2.0|
Edema | | 1 3.0|
Fibrosis | 2 | 2 2.5|
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic Active | 4 2 4| 6 3.2|
Inflammation, Suppurative | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Joint, Tarsal, Metaplasia, Osseous | 4 4 3 4 4| 11 3.9|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3| |
| 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | M + + + + + + + + + + + + + + M + + + + M + + + +| 43 |
Sciatic, Degeneration | | 3 1.3|
__________________________________________________________________________|____________|
Spinal Cord | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
White Matter, Degeneration | 1 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | 2 | 2 2.5|
Inflammation, Chronic | 1 3 2 2 1 2 3 2 1 4| 20 2.1|
Leukocytosis | | 1 |
Alveolar Epithelium, Hyperplasia | 1 2 2 2 2 3 3 2 2 | 19 2.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 4 |
Cornea, Inflammation, Chronic Active | 4 | 1 4.0|
Lens, Cataract | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Cyst | X | 1 |
Infarct | 2 2 4 | 8 3.1|
Inflammation, Suppurative | | 1 3.0|
Mineralization | 2 1 1 1 1 | 8 1.5|
Nephropathy, Chronic | 2 2 1 2 2 2 2 2 1 2 2 2 2| 22 1.8|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + + + + + + + +| 38 |
__________________________________________________________________________|____________|
Urethra | + + + + + + + + + + + + + + + +| 35 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05024-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 13:02:46
__________________________________________________________________________________________________________________________________
| 1| 6| 6| 7| 5| 4| 7| 7| 7| 7| 7| 7| 6| 4| 2| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 4| 4| 3| 8| 8| 3| 2| 3| 3| 3| 3| 8| 7| 5| 3| 3| 7| 3| 6| 2| 3| 3| 3| 3| |
| 1| 7| 5| 1| 9| 5| 1| 9| 2| 1| 2| 1| 7| 6| 7| 2| 3| 0| 2| 8| 8| 3| 2| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
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