TDMS Study 05024-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/04/94
EXP: 05024 N-METHYLOLACRYLAMIDE TIME: 04:50:36
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60333
CONT: NO1CP9565302 CAS: 924-42-5
PATHOLOGIST: J. TOFT S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/04/94
EXP: 05024 N-METHYLOLACRYLAMIDE TIME: 04:50:36
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60333
CONT: NO1CP9565302 CAS: 924-42-5
PATHOLOGIST: J. TOFT S. EUSTIS
N-METHYLOLACRYLAMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 103 182 199 220 297 432 464 467 528 589 |
| 617 624 638 661 673 675 683 683 684 729 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 50 112 117 126 135 165 201 221 415 432 |
| 455 460 485 501 502 600 611 617 634 634 |
| 652 683 684 686 687 690 691 708 711 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 181 257 366 444 476 476 478 485 486 501 |
| 502 528 548 569 582 589 626 645 645 647 |
| 654 667 668 670 687 690 691 729 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
N-METHYLOLACRYLAMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 98.0 92.0 90.0 90.0 84.0 82.0 80.0 72.0 60.0 |
|CONTROL | |
| | |
|25 MG/KG | 98.0 88.0 84.0 84.0 82.0 74.0 70.0 68.0 58.0 40.0 |
| | |
| | |
|50 MG/KG | 100.0 100.0 96.0 96.0 94.0 84.0 76.0 68.0 58.0 42.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 25 MG/KG 50 MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.0% 40.0% 42.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.125 P=0.070 P=0.128 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 507.4 479.7 559.2 |
|NATURAL DEATHS (C) | (45.1) (41.5) (25.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 641.6 580.2 631.3 |
|(STANDARD ERROR) | (23.7) (30.4) (18.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
N-METHYLOLACRYLAMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 1 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 563 655 675 684 690 690 716 724 |
| CENSORED DEATHS |
| 401 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 347 421 548 592 592 616 669 675 681 688 |
| 690 694 705 710 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 1 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 527 528 553 580 589 647 653 655 667 667 |
| 672 674 711 723 729 729 |
| CENSORED DEATHS |
| 653 |
| |
==================================================================================
N-METHYLOLACRYLAMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 95.9 83.7 |
|CONTROL | |
| | |
|25 MG/KG | 100.0 100.0 100.0 98.0 96.0 96.0 96.0 90.0 88.0 70.0 |
| | |
| | |
|50 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 90.0 84.0 67.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 25 MG/KG 50 MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 83.7% 70.0% 67.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.074 P=0.142 P=0.081 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 674.6 623.1 644.0 |
|NATURAL DEATHS (C) | (17.7) (28.4) (17.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 715.4 698.6 701.6 |
|(STANDARD ERROR) | ( 7.6) (10.9) ( 7.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
N-METHYLOLACRYLAMIDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
25 MG/KG = 2
50 MG/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
| 2 12 1 3
| 222 1 1 1 3 3 3
| 2 2 1 1 3 3
P 90 + 2 2 1 1
E | 2 2 1 133
R | 2 2 2 1 33 1
C | 2 2 3 3 1 1
E 80 + 2 2 1 1
N | 22 3 3 11
T | 2 2 2 3 3 3 1 1 1
| 3 3 1 1
S 70 + 2 3 32
U | 32 2 3 11
R | 2232 3
V | 1 1
I 60 + 2 32 1
V | 2 3 2
A |
L | 3 22
50 +
|
| 2 2 3
| 2 2 3
40 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.
N-METHYLOLACRYLAMIDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
25 MG/KG = 2
50 MG/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
|
| 2 2 1 1
| 2 3 2 1 1
95 +
| 2 3 2 11
P | 3 3
E | 11
R 90 + 2 2 3
C |
E | 2 33 2 1 1
N | 22 11
T 85 +
| 3 322 1 1
S | 22
U |
R 80 +
V |
I | 33 22
V | 3 223
A 75 +
L | 22 3
| 22
| 3 3
70 + 2 2
|
| 3
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 6 obs hidden.
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