TDMS Study 05024-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
N-METHYLOLACRYLAMIDE
NTP Experiment-Test: 05024-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/04/94
Route: GAVAGE Time: 03:20:11
Facility: Battelle Columbus Laboratory
Chemical CAS #: 924-42-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05024-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 03:20:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 6 MG/KG 12 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 10 20 12
Dead 5 8 5
Survivors
Terminal Sacrifice 35 22 33
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (16) (50)
Foreign Body 1 (6%) 1 (2%)
Inflammation, Chronic Active 1 (6%)
Inflammation, Suppurative 1 (2%)
Intestine Large, Cecum (48) (14) (48)
Parasite Metazoan 1 (7%)
Intestine Large, Colon (48) (16) (49)
Parasite Metazoan 1 (2%) 4 (8%)
Intestine Large, Rectum (46) (16) (46)
Parasite Metazoan 3 (7%) 1 (6%) 1 (2%)
Intestine Small, Duodenum (49) (16) (50)
Diverticulum 1 (2%)
Liver (50) (21) (50)
Angiectasis 1 (2%)
Basophilic Focus 40 (80%) 7 (33%) 37 (74%)
Clear Cell Focus 1 (2%)
Degeneration, Cystic 2 (4%)
Hepatodiaphragmatic Nodule 6 (12%) 2 (10%) 5 (10%)
Inflammation, Chronic 27 (54%) 7 (33%) 29 (58%)
Inflammation, Necrotizing 4 (8%)
Necrosis, Coagulative 1 (2%) 2 (4%)
Vacuolization Cytoplasmic 2 (4%) 1 (5%)
Portal Vein, Necrosis, Fibrinoid 1 (2%)
Portal Vein, Intima, Proliferation 1 (2%)
Mesentery (49) (18) (49)
Inflammation, Chronic Active 1 (2%) 2 (11%) 1 (2%)
Necrosis 2 (11%) 1 (2%)
Pancreas (50) (17) (50)
Acinus, Atrophy 6 (12%) 2 (12%) 10 (20%)
Duct, Ectasia 1 (2%)
Salivary Glands (50) (16) (50)
Atrophy 1 (2%)
Stomach, Forestomach (49) (16) (50)
Inflammation, Chronic Active 2 (4%) 1 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05024-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 03:20:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 6 MG/KG 12 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Ulcer 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Stomach, Glandular (49) (16) (50)
Inflammation, Chronic Active 2 (13%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (16) (47)
Pulmonary Artery, Mineralization 1 (2%)
Heart (50) (16) (50)
Cardiomyopathy, Chronic 47 (94%) 7 (44%) 48 (96%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Atrium, Thrombosis 1 (6%) 1 (2%)
Valve, Bacterium 1 (6%) 1 (2%)
Valve, Inflammation, Chronic Active 1 (6%)
Valve, Thrombosis 1 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50) (50)
Capsule, Inflammation, Chronic 1 (2%)
Adrenal Gland, Cortex (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%)
Cyst 1 (2%)
Degeneration, Fatty 10 (20%) 17 (34%) 16 (32%)
Hyperplasia 13 (26%) 16 (32%) 18 (36%)
Hypertrophy 2 (4%) 5 (10%) 8 (16%)
Infiltration Cellular, Lymphocyte 1 (2%)
Adrenal Gland, Medulla (50) (50) (50)
Hyperplasia 4 (8%) 5 (10%) 6 (12%)
Pituitary Gland (49) (40) (50)
Pars Distalis, Angiectasis 6 (12%)
Pars Distalis, Cyst 14 (29%) 10 (25%) 25 (50%)
Pars Distalis, Hyperplasia 11 (22%) 11 (28%) 12 (24%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (50) (17) (50)
C-Cell, Hyperplasia 20 (40%) 3 (18%) 14 (28%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05024-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 03:20:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 6 MG/KG 12 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (45) (17) (50)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (6%) 1 (2%)
Duct, Dilatation 1 (2%)
Ovary (50) (20) (50)
Cyst 4 (8%) 4 (20%) 3 (6%)
Uterus (50) (19) (50)
Dilatation 6 (12%) 6 (12%)
Diverticulum 1 (5%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (11%)
Cervix, Fibrosis 1 (2%)
Endometrium, Hyperplasia, Cystic, Glandular 8 (16%) 1 (5%) 14 (28%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (16) (50)
Femoral, Hyperplasia 1 (2%)
Femoral, Hyperplasia, Reticulum Cell 5 (10%) 3 (19%) 3 (6%)
Femoral, Myelofibrosis 1 (6%) 1 (2%)
Femoral, Myeloid Cell, Hyperplasia 1 (6%)
Vertebral, Hyperplasia 1 (2%)
Lymph Node (50) (21) (50)
Mandibular, Hyperplasia, Plasma Cell 1 (5%) 1 (2%)
Mandibular, Pigmentation, Hemosiderin 1 (2%)
Mediastinal, Inflammation, Necrotizing 1 (5%)
Mediastinal, Pigmentation, Hemosiderin 37 (74%) 37 (74%)
Pancreatic, Pigmentation, Hemosiderin 1 (2%)
Spleen (50) (22) (50)
Fibrosis 1 (5%)
Hematopoietic Cell Proliferation 26 (52%) 2 (9%) 32 (64%)
Pigmentation, Hemosiderin 31 (62%) 32 (64%)
Thrombosis 1 (5%)
Thymus (38) (16) (41)
Cyst 2 (5%) 4 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05024-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 03:20:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 6 MG/KG 12 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (24) (50)
Hyperplasia, Cystic 48 (98%) 18 (75%) 48 (96%)
Skin (50) (24) (50)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (16) (50)
Femur, Fibrous Osteodystrophy 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (16) (50)
Compression 14 (28%) 4 (25%) 13 (26%)
Hydrocephalus 2 (13%) 2 (4%)
Inflammation, Chronic Active 1 (6%)
Spinal Cord (50) (16) (50)
White Matter, Degeneration 18 (36%) 11 (22%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (17) (50)
Granuloma 7 (41%) 5 (10%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (6%)
Alveolar Epithelium, Hyperplasia 1 (2%) 3 (6%)
Nose (50) (16) (50)
Inflammation, Chronic Active 3 (6%) 1 (2%)
Nasolacrimal Duct, Granuloma 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 20 (40%) 20 (40%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (5) (6)
Lens, Cataract 2 (40%) 2 (40%) 5 (83%)
Retina, Atrophy 2 (40%) 1 (20%) 3 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05024-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 03:20:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 6 MG/KG 12 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (17) (50)
Bacterium 1 (6%) 1 (2%)
Calculus Micro Observation Only 2 (4%)
Hydronephrosis 2 (4%)
Infarct 1 (6%)
Inflammation, Chronic Active 2 (4%) 1 (6%) 1 (2%)
Mineralization 1 (2%)
Nephropathy, Chronic 48 (96%) 11 (65%) 44 (88%)
Pigmentation, Hemosiderin 1 (6%)
Renal Tubule, Atrophy 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (50) (14) (50)
Calculus Micro Observation Only 1 (2%)
Dilatation 1 (7%)
Inflammation, Chronic Active 1 (7%)
Transitional Epithelium, Hyperplasia 2 (4%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05024-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 03:20:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 6 MG/KG 12 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 15 21 19
Dead 7 7 4
Survivors
Terminal Sacrifice 28 21 27
Moribund 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (16) (50)
Foreign Body 1 (6%)
Inflammation, Necrotizing 1 (2%)
Intestine Large, Colon (49) (14) (50)
Parasite Metazoan 4 (8%) 6 (12%)
Intestine Large, Rectum (49) (15) (49)
Inflammation, Chronic Active 1 (7%)
Parasite Metazoan 3 (6%) 1 (7%) 4 (8%)
Liver (50) (50) (50)
Basophilic Focus 7 (14%) 14 (28%) 5 (10%)
Clear Cell Focus 1 (2%) 1 (2%) 1 (2%)
Clear Cell Focus, Multiple 1 (2%)
Degeneration, Cystic 10 (20%) 8 (16%) 19 (38%)
Eosinophilic Focus 1 (2%)
Fatty Change 2 (4%)
Hepatodiaphragmatic Nodule 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic 3 (6%) 7 (14%) 7 (14%)
Inflammation, Necrotizing 1 (2%)
Leukocytosis 1 (2%)
Mineralization 1 (2%) 1 (2%)
Necrosis, Coagulative 2 (4%) 2 (4%) 5 (10%)
Vacuolization Cytoplasmic 1 (2%) 4 (8%) 1 (2%)
Pancreas (50) (17) (50)
Cyst 1 (6%)
Inflammation, Chronic 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Acinus, Atrophy 15 (30%) 9 (53%) 15 (30%)
Acinus, Hyperplasia 1 (2%)
Artery, Inflammation, Proliferative 3 (18%)
Salivary Glands (50) (15) (49)
Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (50) (15) (50)
Inflammation, Chronic Active 2 (4%) 2 (13%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05024-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 03:20:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 6 MG/KG 12 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mineralization 1 (2%)
Epithelium, Hyperplasia 1 (7%)
Stomach, Glandular (50) (14) (50)
Mineralization 1 (2%) 3 (6%)
Necrosis, Coagulative 1 (2%)
Tooth (49) (16) (50)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (49) (16) (48)
Aorta, Mineralization 1 (2%)
Mesenteric Artery, Mineralization 1 (2%)
Mesenteric Artery, Intima, Proliferation 1 (2%)
Pulmonary Artery, Mineralization 1 (2%)
Heart (50) (21) (50)
Cardiomyopathy, Chronic 48 (96%) 16 (76%) 48 (96%)
Infarct 1 (2%)
Mineralization 3 (6%)
Atrium, Thrombosis 3 (6%) 6 (29%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Degeneration, Fatty 8 (16%) 12 (24%) 9 (18%)
Hyperplasia 10 (20%) 10 (20%) 15 (30%)
Hypertrophy 1 (2%) 2 (4%) 4 (8%)
Mineralization 1 (2%)
Necrosis, Coagulative 1 (2%)
Adrenal Gland, Medulla (49) (50) (50)
Angiectasis 1 (2%)
Atypia Cellular 1 (2%)
Hyperplasia 13 (27%) 24 (48%) 16 (32%)
Necrosis, Coagulative 2 (4%)
Islets, Pancreatic (50) (14) (50)
Vacuolization Cytoplasmic 1 (7%)
Parathyroid Gland (48) (14) (45)
Hyperplasia 1 (2%) 2 (14%) 3 (7%)
Pituitary Gland (50) (23) (50)
Pars Distalis, Cyst 4 (8%) 1 (4%) 2 (4%)
Pars Distalis, Hyperplasia 18 (36%) 3 (13%) 15 (30%)
Pars Distalis, Pigmentation, Hemosiderin 1 (2%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Cyst 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05024-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 03:20:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 6 MG/KG 12 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (50) (17) (50)
Mineralization 1 (2%)
C-Cell, Hyperplasia 9 (18%) 5 (29%) 17 (34%)
Follicular Cell, Hyperplasia 1 (2%) 7 (41%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (36) (13) (32)
Inflammation, Chronic Active 2 (6%)
Epididymis (50) (16) (49)
Angiectasis 1 (2%)
Inflammation, Chronic 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Preputial Gland (49) (17) (48)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic Active 42 (86%) 16 (94%) 42 (88%)
Prostate (50) (19) (49)
Abscess 1 (2%)
Atrophy 1 (2%)
Inflammation, Chronic Active 29 (58%) 14 (74%) 30 (61%)
Seminal Vesicle (35) (16) (40)
Inflammation, Chronic Active 1 (6%)
Testes (50) (48) (50)
Hyperplasia 2 (4%)
Mineralization 17 (34%) 19 (40%) 10 (20%)
Interstitial Cell, Hyperplasia 25 (50%) 28 (58%) 27 (54%)
Perivascular, Atrophy 1 (2%)
Rete Testes, Hyperplasia 1 (2%)
Seminiferous Tubule, Atrophy 40 (80%) 40 (83%) 46 (92%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (16) (50)
Femoral, Hyperplasia 1 (2%)
Femoral, Hyperplasia, Reticulum Cell 1 (2%) 1 (2%)
Femoral, Myelofibrosis 1 (6%) 1 (2%)
Vertebral, Hyperplasia 1 (2%)
Vertebral, Hyperplasia, Reticulum Cell 1 (2%)
Vertebral, Myelofibrosis 1 (2%)
Lymph Node (50) (25) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05024-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 03:20:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 6 MG/KG 12 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Bronchial, Pigmentation, Hemosiderin 3 (6%) 1 (2%)
Mandibular, Cyst 4 (8%) 1 (2%)
Mandibular, Hyperplasia, Plasma Cell 3 (6%) 1 (4%) 1 (2%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (4%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Mediastinal, Inflammation, Chronic Active 1 (4%)
Mediastinal, Pigmentation, Hemosiderin 1 (2%) 2 (4%)
Renal, Hemorrhage 1 (2%)
Renal, Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mesenteric (15) (6) (8)
Cyst 1 (17%)
Hemorrhage 2 (13%)
Infiltration Cellular, Histiocyte 1 (7%)
Inflammation, Proliferative 1 (17%)
Spleen (50) (47) (50)
Fibrosis 5 (10%) 10 (21%) 9 (18%)
Hematopoietic Cell Proliferation 18 (36%) 1 (2%) 8 (16%)
Hyperplasia, Lymphoid 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Lipocyte 1 (2%)
Necrosis, Coagulative 1 (2%)
Pigmentation, Hemosiderin 3 (6%)
Thymus (37) (14) (35)
Cyst 3 (8%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (37) (15) (39)
Hyperplasia, Cystic 37 (100%) 12 (80%) 36 (92%)
Skin (50) (25) (50)
Cyst Epithelial Inclusion 1 (4%)
Fibrosis 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (8%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (16) (50)
Cranium, Fibrous Osteodystrophy 1 (2%) 2 (4%)
Femur, Fibrous Osteodystrophy 1 (2%) 2 (4%)
Vertebra, Fibrous Osteodystrophy 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05024-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 03:20:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 6 MG/KG 12 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (48) (16) (50)
Compression 4 (8%) 4 (25%) 9 (18%)
Hemorrhage 3 (6%) 1 (6%) 1 (2%)
Hydrocephalus 2 (4%) 5 (31%) 2 (4%)
Inflammation, Chronic 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Thrombosis 1 (2%)
White Matter, Degeneration 1 (2%)
Spinal Cord (50) (15) (49)
Hemorrhage, Acute 1 (2%)
White Matter, Degeneration 19 (38%) 21 (43%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (17) (49)
Bacterium 1 (6%)
Granuloma 2 (12%)
Inflammation, Chronic Active 4 (8%) 2 (12%) 1 (2%)
Metaplasia, Osseous 1 (6%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Alveolar Epithelium, Hyperplasia, Adenomatous 3 (6%) 2 (12%) 3 (6%)
Artery, Mediastinum, Necrosis, Fibrinoid 1 (2%) 1 (2%)
Interstitium, Inflammation, Chronic 4 (8%)
Mediastinum, Inflammation, Chronic Active 1 (2%) 1 (2%)
Nose (50) (16) (50)
Inflammation, Chronic Active 4 (8%) 1 (6%) 2 (4%)
Inflammation, Suppurative 1 (6%)
Nasolacrimal Duct, Inflammation, Chronic 15 (30%) 12 (24%)
Nasolacrimal Duct, Inflammation, Suppurative 4 (8%) 3 (6%)
Trachea (50) (15) (50)
Inflammation, Chronic Active 1 (2%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (6) (6)
Hemorrhage 1 (17%) 1 (17%)
Lens, Cataract 1 (33%) 1 (17%) 2 (33%)
Retina, Atrophy 1 (33%) 2 (33%) 2 (33%)
Harderian Gland (8) (12) (8)
Hemorrhage 1 (13%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05024-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 09/04/94
Route: GAVAGE Time: 03:20:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 6 MG/KG 12 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (36) (50)
Cyst 6 (12%) 8 (22%) 6 (12%)
Hydronephrosis 1 (2%)
Inflammation, Chronic 1 (3%)
Mineralization 1 (2%)
Nephropathy, Chronic 50 (100%) 36 (100%) 50 (100%)
Urinary Bladder (50) (18) (49)
Inflammation, Chronic Active 1 (2%) 2 (11%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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