TDMS Study 05024-01 Pathology Tables
NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 Facility: Battelle Columbus Laboratory Chemical CAS #: 924-42-5 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 8| 3| 2| 3| 3| 5| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7| | 2| 2| 3| 1| 1| 3| 5| 1| 9| 1| 1| 2| 2| 3| 3| 1| 6| 2| 2| 2| 2| 2| 1| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + M + + M M + M M + + + + + M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X| Pars Distalis, Adenoma | X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X X X X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 8| 3| 2| 3| 3| 5| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7| | 2| 2| 3| 1| 1| 3| 5| 1| 9| 1| 1| 2| 2| 3| 3| 1| 6| 2| 2| 2| 2| 2| 1| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + + + + + + + M + + + M + + + + + + + + +| Adenoma | | Leukemia Mononuclear | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | | Leukemia Mononuclear | X| __________________________________________________________________________| Oviduct | + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| Polyp | X | Polyp Stromal | X X | Polyp Stromal, Multiple | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Leukemia Mononuclear | X| Vertebral, Leukemia Mononuclear | X| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Leukemia Mononuclear | | Mandibular, Leukemia Mononuclear | X X X| Mediastinal, Leukemia Mononuclear | X X| Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | M M M M M M M M M M M M M M M M + M M M M M M M M| Leukemia Mononuclear | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Thymus | + M + + + + + + + + + M + + + + + + M + M + + + +| Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Fibroadenoma | X X X X X X X | Fibroadenoma, Multiple | X X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Trichoepithelioma | | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Myxoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 8| 3| 2| 3| 3| 5| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7| | 2| 2| 3| 1| 1| 3| 5| 1| 9| 1| 1| 2| 2| 3| 3| 1| 6| 2| 2| 2| 2| 2| 1| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + M + + + + + + + + M + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + +| __________________________________________________________________________| Harderian Gland | + + + + | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Ureter | + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 1| 3| 0| 0| 2| 3| 3| 3| 3| 3| 3| | | 6| 8| 1| 1| 2| 1| 3| 1| 3| 3| 8| 2| 1| 8| 3| 2| 2| 2| 9| 2| 3| 2| 1| 2| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + A A + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A A + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A A + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + M + + + + + + + + + + + + A A + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + A + + + M A + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A A + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 14 | __________________________________________________________________________|____________| Mesentery | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 3 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 4 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + M M + M + M + + M + + M + + M + + + M + + + + +| 34 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X | 3 | Pars Distalis, Adenoma | X X X X X X X X X X X | 19 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 1| 3| 0| 0| 2| 3| 3| 3| 3| 3| 3| | | 6| 8| 1| 1| 2| 1| 3| 1| 3| 3| 8| 2| 1| 8| 3| 2| 2| 2| 9| 2| 3| 2| 1| 2| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Adenoma | X X X X | 11 | C-Cell, Carcinoma | X | 1 | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M + + + + + + M + + + + + + + + + +| 45 | Adenoma | X X | 2 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor Benign | X | 1 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Oviduct | + + + + + + + + + + + + + + + + +| 34 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Polyp | | 1 | Polyp Stromal | X X X X | 6 | Polyp Stromal, Multiple | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Leukemia Mononuclear | X | 2 | Vertebral, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lumbar, Leukemia Mononuclear | X | 1 | Mandibular, Leukemia Mononuclear | X X | 5 | Mediastinal, Leukemia Mononuclear | X X X | 5 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M M M M M M M M M M M M M M M M M M M M M M + M| 3 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 14 | __________________________________________________________________________|____________| Thymus | M + + + + M + M + + + + M + M M + + M + + + M + +| 38 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 1| 3| 0| 0| 2| 3| 3| 3| 3| 3| 3| | | 6| 8| 1| 1| 2| 1| 3| 1| 3| 3| 8| 2| 1| 8| 3| 2| 2| 2| 9| 2| 3| 2| 1| 2| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Adenocarcinoma | | 1 | Fibroadenoma | X X X X X X X X | 15 | Fibroadenoma, Multiple | | 4 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Trichoepithelioma | X | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Myxoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + + + M + + M + + + + + M + + + + +| 45 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 7 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 5 | __________________________________________________________________________|____________| Harderian Gland | + + + + + + | 10 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + | 17 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 4| 7| 7| 7| 2| DAY ON TEST | 3| 3| 1| 3| 2| 3| 3| 3| 4| 3| 1| 3| 3| 3| 8| 7| 1| 6| 6| 3| 5| 3| 2| 3| 9| | 3| 1| 5| 2| 3| 3| 1| 1| 9| 3| 2| 2| 2| 3| 8| 5| 1| 8| 8| 3| 8| 2| 6| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Liver | + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Mesentery | + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Pancreas | + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach | + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + +| __________________________________________________________________________| Tooth | + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + +| __________________________________________________________________________| Heart | + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X | Pars Distalis, Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 4| 7| 7| 7| 2| DAY ON TEST | 3| 3| 1| 3| 2| 3| 3| 3| 4| 3| 1| 3| 3| 3| 8| 7| 1| 6| 6| 3| 5| 3| 2| 3| 9| | 3| 1| 5| 2| 3| 3| 1| 1| 9| 3| 2| 2| 2| 3| 8| 5| 1| 8| 8| 3| 8| 2| 6| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + +| C-Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + +| Adenoma | X X | __________________________________________________________________________| Ovary | + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Oviduct | + +| __________________________________________________________________________| Uterus | + + + + + + + + + +| Polyp Stromal | X X | Sarcoma Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + +| Femoral, Leukemia Mononuclear | | Vertebral, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node | + + + + + + + + +| Inguinal, Leukemia Mononuclear | | Lumbar, Leukemia Mononuclear | | Mandibular, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | M M M M M M +| Leukemia Mononuclear | | __________________________________________________________________________| Spleen | + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Thymus | + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + +| Adenocarcinoma | | Fibroadenoma | X X X X | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + +| Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibrosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 4| 7| 7| 7| 2| DAY ON TEST | 3| 3| 1| 3| 2| 3| 3| 3| 4| 3| 1| 3| 3| 3| 8| 7| 1| 6| 6| 3| 5| 3| 2| 3| 9| | 3| 1| 5| 2| 3| 3| 1| 1| 9| 3| 2| 2| 2| 3| 8| 5| 1| 8| 8| 3| 8| 2| 6| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + +| Cranium, Osteosarcoma | X | __________________________________________________________________________| Skeletal Muscle | + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + M + M + M +| __________________________________________________________________________| Spinal Cord | + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Nose | + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | __________________________________________________________________________| Harderian Gland | + M + + + M M| __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Ureter | + +| __________________________________________________________________________| Urethra | + + | __________________________________________________________________________| Urinary Bladder | + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 5| 4| 7| 7| 5| 7| 1| 6| 6| 6| 7| 7| 7| 6| 5| 5| 4| 7| 7| 6| 5| | DAY ON TEST | 9| 3| 3| 5| 3| 4| 3| 3| 5| 3| 1| 2| 8| 4| 3| 3| 3| 6| 7| 0| 4| 3| 3| 4| 9| | | 8| 3| 1| 6| 5| 3| 3| 3| 0| 2| 9| 6| 4| 1| 1| 1| 3| 7| 5| 8| 3| 2| 2| 4| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + +| 16 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + +| 17 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + +| 14 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + +| 16 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + A + + + + + +| 16 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + +| 16 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + +| 16 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + +| 16 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + +| 16 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + +| 21 | Leukemia Mononuclear | X X X X X X| 8 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + +| 18 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + +| 17 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + +| 16 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + +| 16 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + +| 16 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + +| 16 | __________________________________________________________________________|____________| Tooth | + + + + + + + + +| 16 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + +| 16 | __________________________________________________________________________|____________| Heart | + + + + + + + + +| 16 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X X X X | 8 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 8 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + +| 16 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 5| 4| 7| 7| 5| 7| 1| 6| 6| 6| 7| 7| 7| 6| 5| 5| 4| 7| 7| 6| 5| | DAY ON TEST | 9| 3| 3| 5| 3| 4| 3| 3| 5| 3| 1| 2| 8| 4| 3| 3| 3| 6| 7| 0| 4| 3| 3| 4| 9| | | 8| 3| 1| 6| 5| 3| 3| 3| 0| 2| 9| 6| 4| 1| 1| 1| 3| 7| 5| 8| 3| 2| 2| 4| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M +| 15 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| 40 | Leukemia Mononuclear | X X | 2 | Pars Distalis, Adenoma | X X X X X X X X | 19 | Pars Distalis, Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + +| 17 | C-Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + +| 17 | Adenoma | | 2 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + +| 20 | Leukemia Mononuclear | X| 1 | __________________________________________________________________________|____________| Oviduct | + +| 4 | __________________________________________________________________________|____________| Uterus | + + + + + + + + +| 19 | Polyp Stromal | | 2 | Sarcoma Stromal | X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + +| 16 | Femoral, Leukemia Mononuclear | X | 1 | Vertebral, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + +| 21 | Inguinal, Leukemia Mononuclear | X| 1 | Lumbar, Leukemia Mononuclear | X | 1 | Mandibular, Leukemia Mononuclear | X X| 2 | Mediastinal, Leukemia Mononuclear | X X X X| 5 | Pancreatic, Leukemia Mononuclear | X X X| 5 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + M M M + M M + M M| 4 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + +| 22 | Leukemia Mononuclear | X X X X X X X X| 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + +| 16 | Leukemia Mononuclear | X X| 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 5| 4| 7| 7| 5| 7| 1| 6| 6| 6| 7| 7| 7| 6| 5| 5| 4| 7| 7| 6| 5| | DAY ON TEST | 9| 3| 3| 5| 3| 4| 3| 3| 5| 3| 1| 2| 8| 4| 3| 3| 3| 6| 7| 0| 4| 3| 3| 4| 9| | | 8| 3| 1| 6| 5| 3| 3| 3| 0| 2| 9| 6| 4| 1| 1| 1| 3| 7| 5| 8| 3| 2| 2| 4| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + +| 24 | Adenocarcinoma | X | 1 | Fibroadenoma | X X X X X | 9 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + +| 24 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + +| 16 | Cranium, Osteosarcoma | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + +| 16 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + +| 16 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + + M| 12 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + +| 16 | Leukemia Mononuclear | X X | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + +| 17 | Leukemia Mononuclear | X X X X X| 5 | __________________________________________________________________________|____________| Nose | + + + + + + + + +| 16 | __________________________________________________________________________|____________| Trachea | + + + + + + + + +| 16 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 5 | __________________________________________________________________________|____________| Harderian Gland | M M I + + M + M +| 8 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + +| 17 | Leukemia Mononuclear | X X X X| 4 | __________________________________________________________________________|____________| Ureter | + + | 4 | __________________________________________________________________________|____________| Urethra | | 2 | __________________________________________________________________________|____________| Urinary Bladder | M + + + + M + + +| 14 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 6| 5| 4| 7| 7| 5| 7| 1| 6| 6| 6| 7| 7| 7| 6| 5| 5| 4| 7| 7| 6| 5| | DAY ON TEST | 9| 3| 3| 5| 3| 4| 3| 3| 5| 3| 1| 2| 8| 4| 3| 3| 3| 6| 7| 0| 4| 3| 3| 4| 9| | | 8| 3| 1| 6| 5| 3| 3| 3| 0| 2| 9| 6| 4| 1| 1| 1| 3| 7| 5| 8| 3| 2| 2| 4| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Leukemia Mononuclear | X X X X X X X X| 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 5| 7| 6| 7| 7| 5| 7| 6| 6| 7| 3| DAY ON TEST | 7| 3| 3| 3| 3| 5| 1| 3| 1| 3| 4| 5| 1| 3| 7| 1| 5| 3| 3| 9| 3| 6| 8| 3| 8| | 8| 2| 1| 3| 1| 5| 5| 2| 7| 3| 3| 2| 1| 1| 8| 2| 2| 3| 2| 5| 3| 8| 8| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + M + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tongue | +| Squamous Cell Carcinoma | X| __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + M + M + + + + + + + + + + + + M + + + + + M + M| Adenoma | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 5| 7| 6| 7| 7| 5| 7| 6| 6| 7| 3| DAY ON TEST | 7| 3| 3| 3| 3| 5| 1| 3| 1| 3| 4| 5| 1| 3| 7| 1| 5| 3| 3| 9| 3| 6| 8| 3| 8| | 8| 2| 1| 3| 1| 5| 5| 2| 7| 3| 3| 2| 1| 1| 8| 2| 2| 3| 2| 5| 3| 8| 8| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Oviduct | + + + + + + + + + + + | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp | X | Polyp Stromal | X X | Polyp Stromal, Multiple | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Leukemia Mononuclear | X X | Vertebral, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Inguinal, Leukemia Mononuclear | | Mandibular, Leukemia Mononuclear | X X X X X | Mediastinal, Leukemia Mononuclear | X X X X X | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | M + M M M M M M M M M + M M M M + M M + M M M M M| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Thymus | + + M + + + + + + M + + + + + + + M M + + M + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Fibroadenoma | X X X X X X X | Fibroadenoma, Multiple | | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Sebaceous Gland, Adenoma | | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 5| 7| 6| 7| 7| 5| 7| 6| 6| 7| 3| DAY ON TEST | 7| 3| 3| 3| 3| 5| 1| 3| 1| 3| 4| 5| 1| 3| 7| 1| 5| 3| 3| 9| 3| 6| 8| 3| 8| | 8| 2| 1| 3| 1| 5| 5| 2| 7| 3| 3| 2| 1| 1| 8| 2| 2| 3| 2| 5| 3| 8| 8| 1| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + + + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Ureter | + + + + + + + + + + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 2| 1| 1| 1| 5| 2| 2| 6| 3| 3| 3| 3| 1| 1| 2| 5| 1| 3| 2| 2| 1| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + M + + +| 46 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 14 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 6 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | Pheochromocytoma Benign | X X| 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 2| 1| 1| 1| 5| 2| 2| 6| 3| 3| 3| 3| 1| 1| 2| 5| 1| 3| 2| 2| 1| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + M + + + + M + + + + + + + + + +| 42 | Adenoma | X | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | Pars Distalis, Adenoma | X X X X | 14 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X | 7 | Follicular Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X X | 4 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Oviduct | + + + + + + + + + + + + + + +| 26 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp | | 1 | Polyp Stromal | X X X X | 6 | Polyp Stromal, Multiple | X X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Leukemia Mononuclear | X | 3 | Vertebral, Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inguinal, Leukemia Mononuclear | X | 1 | Mandibular, Leukemia Mononuclear | X X | 7 | Mediastinal, Leukemia Mononuclear | X X | 7 | Pancreatic, Leukemia Mononuclear | | 1 | Renal, Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M M M M M M M M M M M + M M M M M + M M M M M M M| 6 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 15 | __________________________________________________________________________|____________| Thymus | + + M + + + + + + M + + + + + + M M + + + + + + +| 41 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 2| 1| 1| 1| 5| 2| 2| 6| 3| 3| 3| 3| 1| 1| 2| 5| 1| 3| 2| 2| 1| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenocarcinoma | X | 1 | Fibroadenoma | X X X X X X | 13 | Fibroadenoma, Multiple | X X X X| 4 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sebaceous Gland, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Peripheral Nerve | M + + M + + + + + + + + + + + + M M + + + + + + +| 45 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma | X | 1 | Leukemia Mononuclear | X X X| 10 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + + + + + | 6 | __________________________________________________________________________|____________| Harderian Gland | + + + + + | 11 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 9 | __________________________________________________________________________|____________| Ureter | + + + + + + + | 17 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| | | 3| 3| 2| 1| 1| 1| 5| 2| 2| 6| 3| 3| 3| 3| 1| 1| 2| 5| 1| 3| 2| 2| 1| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Leukemia Mononuclear | X X X X X X| 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3| | 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + M + A A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Leukemia Mononuclear | X X X X X X X X | Neoplastic Nodule | X X | __________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | Bilateral, Pheochromocytoma Benign | X X X X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3| | 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X | Pars Distalis, Adenoma, Multiple | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Ductus Deferens | + + + + + + + + | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | Leukemia Mononuclear | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Leukemia Mononuclear | X X X | Femoral, Vertebral, Histiocytic | | Sarcoma | X| Vertebral, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Deep Cervical, Leukemia Mononuclear | X | Inguinal, Leukemia Mononuclear | X | Mandibular, Leukemia Mononuclear | X X X X | Mediastinal, Carcinosarcoma, | | Metastatic, Lung | X | Mediastinal, Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3| | 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Pancreatic, Leukemia Mononuclear | X X | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + M M M M + M M + M + M M + M + M M M M M M| Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Leukemia Mononuclear | X X X X X X X X | Sarcoma | X | __________________________________________________________________________| Thymus | + + M + M + + + M + + + + + + + M + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M M + + + + M + M + + + M + + + M + + + + M| Fibroadenoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Basosquamous Tumor Benign | | Keratoacanthoma | | Leukemia Mononuclear | X | Squamous Cell Papilloma | | Sebaceous Gland, Adenoma | X | Subcutaneous Tissue, Fibroma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Carcinosarcoma | X | Leukemia Mononuclear | X X X X X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Gland | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3| | 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Nasolacrimal Duct, Squamous Cell | | Carcinoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | I | __________________________________________________________________________| Harderian Gland | + + + + + | __________________________________________________________________________| Zymbal's Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Gland | | __________________________________________________________________________| Ureter | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Urethra | + + + + + + + + + + + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Leukemia Mononuclear | X X X X X X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3| | | 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + A + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X | 17 | Neoplastic Nodule | X X | 4 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X | 12 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | Leukemia Mononuclear | X X X X X X X X | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3| | | 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pheochromocytoma Malignant | X X | 2 | Pheochromocytoma Benign | X X X X X X X X | 10 | Bilateral, Pheochromocytoma Benign | X | 8 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 | Adenoma | | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | Pars Distalis, Adenoma | X X X X X X X X| 18 | Pars Distalis, Adenoma, Multiple | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X X| 7 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + + + + + + + + + + + + + + +| 36 | __________________________________________________________________________|____________| Ductus Deferens | + + + + + + +| 15 | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Penis | + + | 3 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 2 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + +| 35 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X | 33 | Interstitial Cell, Adenoma | X X X | 7 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Leukemia Mononuclear | X X X X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3| | | 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Femoral, Vertebral, Histiocytic | | | Sarcoma | | 1 | Vertebral, Leukemia Mononuclear | X X X X | 7 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Deep Cervical, Leukemia Mononuclear | | 1 | Inguinal, Leukemia Mononuclear | | 1 | Mandibular, Leukemia Mononuclear | X X X X X X X X X | 13 | Mediastinal, Carcinosarcoma, | | | Metastatic, Lung | | 1 | Mediastinal, Leukemia Mononuclear | X X X X X X X | 12 | Pancreatic, Leukemia Mononuclear | X | 3 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M M M M M M M M + M M M + M M M M + M + + + M + M| 15 | Leukemia Mononuclear | X X X X | 6 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangioma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X | 18 | Sarcoma | | 1 | __________________________________________________________________________|____________| Thymus | + + + + M M + M + + + + M M + + + + + M M M + + M| 37 | Leukemia Mononuclear | X X X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + M + + + + M + + + M + + + + + + M M + + +| 37 | Fibroadenoma | X X| 2 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | X | 1 | Basosquamous Tumor Benign | X | 1 | Keratoacanthoma | X | 1 | Leukemia Mononuclear | | 1 | Squamous Cell Papilloma | X | 1 | Sebaceous Gland, Adenoma | | 1 | Subcutaneous Tissue, Fibroma | X | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| | DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3| | | 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Peripheral Nerve | M + + + + + + + M + + + M M + + + M + M + + + + +| 43 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Carcinosarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X | 14 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Gland | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | Nasolacrimal Duct, Squamous Cell | | | Carcinoma | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 3 | __________________________________________________________________________|____________| Harderian Gland | + + + | 8 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 12 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Gland | X | 1 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + + + + + + + + + + | 35 | __________________________________________________________________________|____________| Urethra | + + + + + + + | 18 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X | 18 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 5| 5| 7| 7| 5| 7| 6| 5| 4| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 4| DAY ON TEST | 3| 4| 5| 3| 3| 6| 3| 9| 7| 2| 0| 2| 1| 4| 1| 3| 3| 9| 7| 3| 7| 3| 3| 3| 0| | 3| 9| 5| 2| 2| 1| 2| 5| 5| 1| 0| 2| 5| 1| 5| 2| 2| 0| 6| 1| 7| 1| 2| 3| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + A + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + A + + + + + A| __________________________________________________________________________| Intestine Large, Colon | + + A + + + + + A| Mesothelioma Malignant | | __________________________________________________________________________| Intestine Large, Rectum | + + A + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Intestine Small | + + A + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + A| Mesothelioma Malignant | | __________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + A| Mesothelioma Malignant | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Leukemia Mononuclear | X X X X X X X | Neoplastic Nodule | | __________________________________________________________________________| Mesentery | + + + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Pancreas | + + A + + + + + + + + A| Leukemia Mononuclear | | Mesothelioma Malignant | | __________________________________________________________________________| Salivary Glands | + + + + + + + + +| __________________________________________________________________________| Stomach | + + A + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + A + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + A + + + + + A| __________________________________________________________________________| Tooth | + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X | __________________________________________________________________________| Islets, Pancreatic | + + A + + + + + A| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + +| __________________________________________________________________________| Pituitary Gland | M M + + + + + + M + + + + + + I| _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 5| 5| 7| 7| 5| 7| 6| 5| 4| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 4| DAY ON TEST | 3| 4| 5| 3| 3| 6| 3| 9| 7| 2| 0| 2| 1| 4| 1| 3| 3| 9| 7| 3| 7| 3| 3| 3| 0| | 3| 9| 5| 2| 2| 1| 2| 5| 5| 1| 0| 2| 5| 1| 5| 2| 2| 0| 6| 1| 7| 1| 2| 3| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Adenoma | X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + A + + + + + + + A| C-Cell, Adenoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + + + + + + | __________________________________________________________________________| Ductus Deferens | + + + + | __________________________________________________________________________| Epididymis | + + + + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Preputial Gland | + + + + + + + + +| Adenoma | X | Squamous Cell Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + +| Femoral, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + +| Mandibular, Leukemia Mononuclear | X X X | Mediastinal, Leukemia Mononuclear | X X X X X | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | M M + M + + M M + M + M + M| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + A + + + + + + + + + + + + + + + + + + A| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Thymus | + + + + M + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M + M + M +| Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + +| Basal Cell Adenoma | X | Keratoacanthoma | X | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 7| 5| 5| 7| 7| 5| 7| 6| 5| 4| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 4| DAY ON TEST | 3| 4| 5| 3| 3| 6| 3| 9| 7| 2| 0| 2| 1| 4| 1| 3| 3| 9| 7| 3| 7| 3| 3| 3| 0| | 3| 9| 5| 2| 2| 1| 2| 5| 5| 1| 0| 2| 5| 1| 5| 2| 2| 0| 6| 1| 7| 1| 2| 3| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Squamous Cell Papilloma | | Sebaceous Gland, Adenoma | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibroma, | | Multiple | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + +| Glioma Malignant | | Leukemia Mononuclear | | __________________________________________________________________________| Peripheral Nerve | + + + + M + + + +| __________________________________________________________________________| Spinal Cord | + + + + + + + + A| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Nose | + + + + + + + + +| __________________________________________________________________________| Trachea | + + A + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | __________________________________________________________________________| Harderian Gland | + + M + + + M + M| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + A + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Ureter | + + A + + + + | __________________________________________________________________________| Urinary Bladder | + + A + + + + + + +| Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 6| 5| 6| 3| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 3| 3| 0| 0| 3| 0| 9| 4| 7| 2| 3| 3| 8| 0| 3| 3| 3| 9| 9| 3| 3| 9| 3| 3| | | 6| 1| 3| 8| 8| 3| 0| 6| 1| 9| 6| 1| 2| 4| 9| 2| 2| 3| 6| 2| 2| 1| 7| 1| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + | 16 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + | 15 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + A A | 12 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + | 14 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + | 15 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + | 14 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + | 14 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + | 14 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + | 14 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X | 18 | Neoplastic Nodule | X | 1 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + | 16 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + | 17 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + M + | 15 | __________________________________________________________________________|____________| Stomach | + + + + + + + | 15 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + | 15 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + | 14 | __________________________________________________________________________|____________| Tooth | + + + + + + + | 16 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + | 16 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 21 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | Leukemia Mononuclear | X X X X X X | 7 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 6| 5| 6| 3| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 3| 3| 0| 0| 3| 0| 9| 4| 7| 2| 3| 3| 8| 0| 3| 3| 3| 9| 9| 3| 3| 9| 3| 3| | | 6| 1| 3| 8| 8| 3| 0| 6| 1| 9| 6| 1| 2| 4| 9| 2| 2| 3| 6| 2| 2| 1| 7| 1| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pheochromocytoma Malignant | X | 2 | Pheochromocytoma Benign | X X X X X | 7 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + | 14 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + | 14 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + +| 23 | Pars Distalis, Adenoma | X X X X X X | 14 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + M + + | 17 | C-Cell, Adenoma | X X X | 4 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + + + + + + + | 13 | __________________________________________________________________________|____________| Ductus Deferens | + + | 6 | __________________________________________________________________________|____________| Epididymis | + + + + + + + | 16 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + | 17 | Adenoma | X | 2 | Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + | 19 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + | 16 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Bilateral, Mesothelioma Malignant | X | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X| 33 | Interstitial Cell, Adenoma | X X X | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + | 16 | Femoral, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + | 25 | Mandibular, Leukemia Mononuclear | X | 4 | Mediastinal, Leukemia Mononuclear | X X X X X | 10 | Pancreatic, Leukemia Mononuclear | X X | 2 | Renal, Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M M M M M M M | 6 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 6| 5| 6| 3| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 3| 3| 0| 0| 3| 0| 9| 4| 7| 2| 3| 3| 8| 0| 3| 3| 3| 9| 9| 3| 3| 9| 3| 3| | | 6| 1| 3| 8| 8| 3| 0| 6| 1| 9| 6| 1| 2| 4| 9| 2| 2| 3| 6| 2| 2| 1| 7| 1| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X X X X X | 18 | __________________________________________________________________________|____________| Thymus | + + + + + M + | 14 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + | 15 | Fibroadenoma | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + | 25 | Basal Cell Adenoma | | 1 | Keratoacanthoma | X X X X X | 6 | Squamous Cell Papilloma | X X | 2 | Sebaceous Gland, Adenoma | X | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibroma, | | | Multiple | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + | 16 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + | 16 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + | 16 | Glioma Malignant | X | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + + + | 15 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + | 17 | Leukemia Mononuclear | X X X X | 7 | __________________________________________________________________________|____________| Nose | + + + + + + + | 16 | __________________________________________________________________________|____________| Trachea | + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 6 | __________________________________________________________________________|____________| Harderian Gland | + + + M + + + | 12 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + | 36 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 6| 5| 6| 3| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 6| 7| 7| | DAY ON TEST | 2| 3| 3| 0| 0| 3| 0| 9| 4| 7| 2| 3| 3| 8| 0| 3| 3| 3| 9| 9| 3| 3| 9| 3| 3| | | 6| 1| 3| 8| 8| 3| 0| 6| 1| 9| 6| 1| 2| 4| 9| 2| 2| 3| 6| 2| 2| 1| 7| 1| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X X | 14 | __________________________________________________________________________|____________| Ureter | + + + + + + | 12 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + | 18 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X | 18 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 3| 7| 7| 6| 7| 4| DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 0| 9| 2| 3| 3| 3| 4| 2| 6| 3| 3| 5| 1| 2| | 3| 1| 1| 3| 3| 3| 1| 2| 3| 5| 2| 8| 5| 6| 3| 2| 1| 8| 2| 7| 2| 1| 5| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| Lipoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | __________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Benign | X X X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + + + + M + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X| Pars Distalis, Carcinoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 3| 7| 7| 6| 7| 4| DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 0| 9| 2| 3| 3| 3| 4| 2| 6| 3| 3| 5| 1| 2| | 3| 1| 1| 3| 3| 3| 1| 2| 3| 5| 2| 8| 5| 6| 3| 2| 1| 8| 2| 7| 2| 1| 5| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | C-Cell, Adenoma | X X X| C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + + + + + + + + + + + + + +| __________________________________________________________________________| Ductus Deferens | + + + + + + + + | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Penis | + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Adenoma | X X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X | Interstitial Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | Leukemia Mononuclear | X | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Leukemia Mononuclear | X X X X X | Vertebral, Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Leukemia Mononuclear | X X X X X X X | Mediastinal, Leukemia Mononuclear | X X X X X X X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | M M M M M + M M + M M M M M M M + M M M M M M + M| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Thymus | + M + M + M M + + + + + M M + M + + + + + M + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M + + + + + + M M + + M + + + + + + + M M +| Adenocarcinoma | | Adenoma | X | Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 3| 7| 7| 6| 7| 4| DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 0| 9| 2| 3| 3| 3| 4| 2| 6| 3| 3| 5| 1| 2| | 3| 1| 1| 3| 3| 3| 1| 2| 3| 5| 2| 8| 5| 6| 3| 2| 1| 8| 2| 7| 2| 1| 5| 2| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Basal Cell Adenoma | | Keratoacanthoma | X X | Sebaceous Gland, Adenoma | | Subcutaneous Tissue, Fibroma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | Carcinoma, Metastatic, Pituitary | | Gland | | __________________________________________________________________________| Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + + + | __________________________________________________________________________| Harderian Gland | + + + + +| __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Ureter | + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urethra | + + + + + + + + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| | DAY ON TEST | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3| | | 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 24 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lipoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 9 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X X X X X X X X X X | 15 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X | 15 | Pheochromocytoma Benign | X X X X X X | 11 | Bilateral, Pheochromocytoma Benign | X | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + M| 45 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| | DAY ON TEST | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3| | | 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | Pars Distalis, Adenoma | X X X X | 13 | Pars Distalis, Carcinoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X X X X | 9 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + + + + + + + + + + + + + + + + + + | 32 | __________________________________________________________________________|____________| Ductus Deferens | + + + + + + + + + + +| 19 | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Penis | | 2 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | Adenoma | X | 3 | __________________________________________________________________________|____________| Prostate | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +| 40 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 2 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X| 38 | Interstitial Cell, Adenoma | X X X X | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + | 2 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Leukemia Mononuclear | X X X X X X X X | 13 | Vertebral, Leukemia Mononuclear | X X X X X X X | 12 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandibular, Leukemia Mononuclear | X X X X X X X X X X X | 18 | Mediastinal, Leukemia Mononuclear | X X X X X X X X X X X X X | 20 | Renal, Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M M M M + M M M M M M + M + M M M M + M M M M M M| 8 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| | DAY ON TEST | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3| | | 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 24 | __________________________________________________________________________|____________| Thymus | M + M + M M M M + + + + + + + + + + + + + + + M +| 35 | Leukemia Mononuclear | X X | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M + + + M + + + M + + + + + + M + + + + + + M +| 39 | Adenocarcinoma | X | 1 | Adenoma | | 1 | Fibroadenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | X | 1 | Keratoacanthoma | X | 3 | Sebaceous Gland, Adenoma | X | 1 | Subcutaneous Tissue, Fibroma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | X | 1 | Carcinoma, Metastatic, Pituitary | | | Gland | X | 1 | __________________________________________________________________________|____________| Peripheral Nerve | + + + M + + M + + + + + + + + + + + + M + + + + +| 46 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X X X X X X X | 20 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | + + + | 6 | __________________________________________________________________________|____________| Harderian Gland | + + + | 8 | __________________________________________________________________________|____________| Zymbal's Gland | +| 1 | Carcinoma | X| 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 05024-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97 Route: GAVAGE Time: 12:23:03 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| | DAY ON TEST | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3| | | 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X | 20 | __________________________________________________________________________|____________| Ureter | + + + + + + + + + + + + + + +| 36 | __________________________________________________________________________|____________| Urethra | + + + + + + + + + + +| 19 | __________________________________________________________________________|____________| Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X X X | 24 | Mesothelioma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 428792-428792/428792 --multipart-boundary--