TDMS Study 05024-01 Pathology Tables
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
Facility: Battelle Columbus Laboratory
Chemical CAS #: 924-42-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 2| 3| 3| 5| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7|
| 2| 2| 3| 1| 1| 3| 5| 1| 9| 1| 1| 2| 2| 3| 3| 1| 6| 2| 2| 2| 2| 2| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 2 2 1 2 1 1 1 1 2 1 2 2 2 1 2 1 1 |
Inflammation, Necrotizing | 1 |
Necrosis, Coagulative | 4 |
Vacuolization Cytoplasmic | 3 |
Portal Vein, Necrosis, Fibrinoid | |
Portal Vein, Intima, Proliferation | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pulmonary Artery, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 3 2 1 2 2 2 2 2 2 3 2 1 2 2 2 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 2| 3| 3| 5| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7|
| 2| 2| 3| 1| 1| 3| 5| 1| 9| 1| 1| 2| 2| 3| 3| 1| 6| 2| 2| 2| 2| 2| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | X |
Cyst | |
Degeneration, Fatty | 2 2 1 2 1 2 2 2 |
Hyperplasia | 2 2 3 2 3 2 2 2 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M + + M M + M M + + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 1 1 1 2 1 1 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + M + + + M + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 3 |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 1 2 1 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation, | |
Hemosiderin | 2 2 2 2 1 1 2 2 1 2 2 2 2 2 2 2 |
Pancreatic, Pigmentation, Hemosiderin| 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M M M M M M M M M M M M M M M + M M M M M M M M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 4 4 2 2 2 3 2 2 2 |
Pigmentation, Hemosiderin | 2 2 2 1 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + M + + + + + + M + M + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 2| 3| 3| 5| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7|
| 2| 2| 3| 1| 1| 3| 5| 1| 9| 1| 1| 2| 2| 3| 3| 1| 6| 2| 2| 2| 2| 2| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 4 3 4 2 3 3 2 4 1 2 4 3 2 2 2 2 3 4 3 1 3 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + M + + + + + + + + M + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
White Matter, Degeneration | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 2 2 2 2 2 2 2 2 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + +|
Lens, Cataract | 4 3 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X |
Hydronephrosis | 2 |
Inflammation, Chronic Active | 3 4 |
Nephropathy, Chronic | 2 2 3 2 2 1 2 2 2 1 2 2 3 1 1 1 2 2 3 2 2 2 2|
Renal Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 3| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 2| 3| 3| 5| 3| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 7|
| 2| 2| 3| 1| 1| 3| 5| 1| 9| 1| 1| 2| 2| 3| 3| 1| 6| 2| 2| 2| 2| 2| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Ureter | + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Transitional Epithelium, Hyperplasia | 3 4 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 1| 3| 0| 0| 2| 3| 3| 3| 3| 3| 3| |
| 6| 8| 1| 1| 2| 1| 3| 1| 3| 3| 8| 2| 1| 8| 3| 2| 2| 2| 9| 2| 3| 2| 1| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + A A + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A A + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A A + + + + + +| 48 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + A A + + + + + +| 46 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Diverticulum | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + M A + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A A + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 40 |
Clear Cell Focus | X | 1 |
Hepatodiaphragmatic Nodule | X X X | 6 |
Inflammation, Chronic | 2 1 3 2 2 2 2 2 1 2| 27 1.6|
Inflammation, Necrotizing | 2 2 2 | 4 1.8|
Necrosis, Coagulative | | 1 4.0|
Vacuolization Cytoplasmic | 2 | 2 2.5|
Portal Vein, Necrosis, Fibrinoid | 2 | 1 2.0|
Portal Vein, Intima, Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 2 2 2 4 | 6 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Inflammation, Chronic Active | 4 | 2 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pulmonary Artery, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 1| 3| 0| 0| 2| 3| 3| 3| 3| 3| 3| |
| 6| 8| 1| 1| 2| 1| 3| 1| 3| 3| 8| 2| 1| 8| 3| 2| 2| 2| 9| 2| 3| 2| 1| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy, Chronic | 2 2 2 2 3 1 2 2 3 3 2 3 2 2 2 3 2 1 2 2 2 2 2 2 2| 47 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 |
Cyst | X | 1 |
Degeneration, Fatty | 2 1 | 10 1.7|
Hyperplasia | 2 1 2 1 | 13 2.0|
Hypertrophy | 3 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 | 4 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M + M + + M + + M + + M + + + M + + + + +| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | X X X X X X X| 14 |
Pars Distalis, Hyperplasia | 3 2 1 3 2 2| 11 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 1 2 2 1 2 2| 20 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + + + + + + M + + + + + + + + + +| 45 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 2 2 | 2 2.0|
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X | 4 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + + + +| 34 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 3 3 3| 6 3.3|
Inflammation, Chronic Active | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 4 1 | 8 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 1| 3| 0| 0| 2| 3| 3| 3| 3| 3| 3| |
| 6| 8| 1| 1| 2| 1| 3| 1| 3| 3| 8| 2| 1| 8| 3| 2| 2| 2| 9| 2| 3| 2| 1| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Femoral, Hyperplasia, Reticulum Cell | 2 2 2 2 2| 5 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2| 37 1.9|
Pancreatic, Pigmentation, Hemosiderin| | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M M M M M M M M M M M M M M M M M M M M M M + M| 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 2 2 2 2 2 2| 26 2.3|
Pigmentation, Hemosiderin | 2 2 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2 2 2| 31 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + M + M + + + + M + M M + + M + + + M + +| 38 |
Cyst | X X| 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Hyperplasia, Cystic | 3 2 2 3 3 2 3 2 3 4 4 4 2 4 3 4 2 4 2 2 3 2 3 2| 48 2.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X X X | 14 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + M + + M + + + + + M + + + + +| 45 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
White Matter, Degeneration | 1 1 1 1 1 1 1 1 1| 18 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 3 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 1 2 2 2 2 2 2 2| 20 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 7| 9| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 1| 1| 3| 0| 0| 2| 3| 3| 3| 3| 3| 3| |
| 6| 8| 1| 1| 2| 1| 3| 1| 3| 3| 8| 2| 1| 8| 3| 2| 2| 2| 9| 2| 3| 2| 1| 2| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Lens, Cataract | | 2 3.5|
Retina, Atrophy | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + | 10 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | | 2 |
Hydronephrosis | 4 | 2 3.0|
Inflammation, Chronic Active | | 2 3.5|
Nephropathy, Chronic | 2 1 2 2 4 2 1 2 2 2 1 2 2 2 2 1 4 2 1 2 1 2 2 2 1| 48 1.9|
Renal Tubule, Atrophy | | 1 4.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | | 1 |
Transitional Epithelium, Hyperplasia | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 4| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 1| 3| 2| 3| 3| 3| 4| 3| 1| 3| 3| 3| 8| 7| 1| 6| 6| 3| 5| 3| 2| 3| 9|
| 3| 1| 5| 2| 3| 3| 1| 1| 9| 3| 2| 2| 2| 3| 8| 5| 1| 8| 8| 3| 8| 2| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + +|
Foreign Body | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + +|
Basophilic Focus | X X X X X |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 2 1 1 1 1 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Inflammation, Chronic Active | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Acinus, Atrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + +|
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Tooth | + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 |
Atrium, Thrombosis | |
Valve, Bacterium | |
Valve, Inflammation, Chronic Active | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 4| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 1| 3| 2| 3| 3| 3| 4| 3| 1| 3| 3| 3| 8| 7| 1| 6| 6| 3| 5| 3| 2| 3| 9|
| 3| 1| 5| 2| 3| 3| 1| 1| 9| 3| 2| 2| 2| 3| 8| 5| 1| 8| 8| 3| 8| 2| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Fatty | 2 1 2 2 1 2 1 2 3 2 2 |
Hyperplasia | 2 1 1 1 2 2 1 2 2 3 |
Hypertrophy | 1 1 4 2 1 |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + +|
Cyst | |
__________________________________________________________________________|
Oviduct | + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + +|
Diverticulum | 4 |
Inflammation, Chronic Active | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 2 2 |
Femoral, Myelofibrosis | |
Femoral, Myeloid Cell, Hyperplasia | 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Mandibular, Hyperplasia, Plasma Cell | |
Mediastinal, Inflammation, | |
Necrotizing | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M M M M M +|
__________________________________________________________________________|
Spleen | + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 6| 7| 4| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 1| 3| 2| 3| 3| 3| 4| 3| 1| 3| 3| 3| 8| 7| 1| 6| 6| 3| 5| 3| 2| 3| 9|
| 3| 1| 5| 2| 3| 3| 1| 1| 9| 3| 2| 2| 2| 3| 8| 5| 1| 8| 8| 3| 8| 2| 6| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 1 2 1 4 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + +|
Compression | X |
Hydrocephalus | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Peripheral Nerve | + M + M + M +|
__________________________________________________________________________|
Spinal Cord | + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + +|
Granuloma | 1 1 1 2 1 1|
Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Nose | + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 2 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + M + + + M M|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + +|
Bacterium | |
Infarct | |
Inflammation, Chronic Active | |
Nephropathy, Chronic | 1 1 1 1 1 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Ureter | + +|
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + +|
Dilatation | 4|
Inflammation, Chronic Active | 2|
Transitional Epithelium, Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 4| 7| 7| 5| 7| 1| 6| 6| 6| 7| 7| 7| 6| 5| 5| 4| 7| 7| 6| 5| |
DAY ON TEST | 9| 3| 3| 5| 3| 4| 3| 3| 5| 3| 1| 2| 8| 4| 3| 3| 3| 6| 7| 0| 4| 3| 3| 4| 9| |
| 8| 3| 1| 6| 5| 3| 3| 3| 0| 2| 9| 6| 4| 1| 1| 1| 3| 7| 5| 8| 3| 2| 2| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + +| 16 |
Foreign Body | | 1 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + +| 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + +| 14 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + +| 16 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + +| 21 |
Basophilic Focus | X X | 7 |
Hepatodiaphragmatic Nodule | | 2 |
Inflammation, Chronic | 2 | 7 1.4|
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + +| 18 |
Inflammation, Chronic Active | 3 4 | 2 3.5|
Necrosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + +| 17 |
Acinus, Atrophy | 1 | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + +| 16 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + +| 16 |
Inflammation, Chronic Active | 3 | 2 2.5|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + +| 16 |
Cardiomyopathy, Chronic | 2 2 2 3 | 7 2.1|
Atrium, Thrombosis | X | 1 |
Valve, Bacterium | X | 1 |
Valve, Inflammation, Chronic Active | 3 | 1 3.0|
Valve, Thrombosis | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 4| 7| 7| 5| 7| 1| 6| 6| 6| 7| 7| 7| 6| 5| 5| 4| 7| 7| 6| 5| |
DAY ON TEST | 9| 3| 3| 5| 3| 4| 3| 3| 5| 3| 1| 2| 8| 4| 3| 3| 3| 6| 7| 0| 4| 3| 3| 4| 9| |
| 8| 3| 1| 6| 5| 3| 3| 3| 0| 2| 9| 6| 4| 1| 1| 1| 3| 7| 5| 8| 3| 2| 2| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Inflammation, Chronic | 2| 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 2 1 1 3 2 2 | 17 1.8|
Hyperplasia | 1 2 2 2 1 2 | 16 1.7|
Hypertrophy | | 5 1.8|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 5 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M +| 15 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| 40 |
Pars Distalis, Cyst | X X X X X X X| 10 |
Pars Distalis, Hyperplasia | 3 2 3 2 2 2 3 2 | 11 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + +| 17 |
C-Cell, Hyperplasia | 1 2| 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + +| 17 |
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + +| 20 |
Cyst | X X X X| 4 |
__________________________________________________________________________|____________|
Oviduct | + +| 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + +| 19 |
Diverticulum | | 1 4.0|
Inflammation, Chronic Active | 3 | 2 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + +| 16 |
Femoral, Hyperplasia, Reticulum Cell | 1 | 3 1.7|
Femoral, Myelofibrosis | 2 | 1 2.0|
Femoral, Myeloid Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 4| 7| 7| 5| 7| 1| 6| 6| 6| 7| 7| 7| 6| 5| 5| 4| 7| 7| 6| 5| |
DAY ON TEST | 9| 3| 3| 5| 3| 4| 3| 3| 5| 3| 1| 2| 8| 4| 3| 3| 3| 6| 7| 0| 4| 3| 3| 4| 9| |
| 8| 3| 1| 6| 5| 3| 3| 3| 0| 2| 9| 6| 4| 1| 1| 1| 3| 7| 5| 8| 3| 2| 2| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + +| 21 |
Mandibular, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Mediastinal, Inflammation, | | |
Necrotizing | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M M M + M M + M M| 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + +| 22 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + +| 24 |
Hyperplasia, Cystic | 3 1 3 1 2 4 2 3 2 3| 18 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + +| 24 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + +| 16 |
Compression | X X X | 4 |
Hydrocephalus | 3 2 | 2 2.5|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + M| 12 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + +| 17 |
Granuloma | 2 | 7 1.3|
Pigmentation, Hemosiderin | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Lens, Cataract | | 2 3.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 4| 7| 7| 5| 7| 1| 6| 6| 6| 7| 7| 7| 6| 5| 5| 4| 7| 7| 6| 5| |
DAY ON TEST | 9| 3| 3| 5| 3| 4| 3| 3| 5| 3| 1| 2| 8| 4| 3| 3| 3| 6| 7| 0| 4| 3| 3| 4| 9| |
| 8| 3| 1| 6| 5| 3| 3| 3| 0| 2| 9| 6| 4| 1| 1| 1| 3| 7| 5| 8| 3| 2| 2| 4| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | M M I + + M + M +| 8 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + +| 17 |
Bacterium | X | 1 |
Infarct | 4 | 1 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Nephropathy, Chronic | 3 2 3 1 3 1| 11 1.6|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ureter | + + | 4 |
__________________________________________________________________________|____________|
Urethra | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + M + + +| 14 |
Dilatation | | 1 4.0|
Inflammation, Chronic Active | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 5| 7| 6| 7| 7| 5| 7| 6| 6| 7| 3|
DAY ON TEST | 7| 3| 3| 3| 3| 5| 1| 3| 1| 3| 4| 5| 1| 3| 7| 1| 5| 3| 3| 9| 3| 6| 8| 3| 8|
| 8| 2| 1| 3| 1| 5| 5| 2| 7| 3| 3| 2| 1| 1| 8| 2| 2| 3| 2| 5| 3| 8| 8| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Inflammation, Suppurative | 2|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + M + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X |
Degeneration, Cystic | 3 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 1 2 1 1 1 1 1 3 2 1 1 2 2 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 3 1|
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Tongue | +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 2 2 3 2 1 2 2 3 1 2 2 1 2 2 2 2 2 2 2 2 2 1|
Inflammation, Chronic Active | |
Mineralization | 1 |
Atrium, Thrombosis | |
Valve, Bacterium | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 5| 7| 6| 7| 7| 5| 7| 6| 6| 7| 3|
DAY ON TEST | 7| 3| 3| 3| 3| 5| 1| 3| 1| 3| 4| 5| 1| 3| 7| 1| 5| 3| 3| 9| 3| 6| 8| 3| 8|
| 8| 2| 1| 3| 1| 5| 5| 2| 7| 3| 3| 2| 1| 1| 8| 2| 2| 3| 2| 5| 3| 8| 8| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Degeneration, Fatty | 2 1 2 2 2 1 1 |
Hyperplasia | 2 1 2 2 2 1 2 1 |
Hypertrophy | 2 3 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + + + + + + + + M + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X X X|
Pars Distalis, Hyperplasia | 2 2 3 2 1 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 |
Diverticulum | |
Hemorrhage | 4 |
Cervix, Fibrosis | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 1 2 1 1 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 4 |
Femoral, Hyperplasia, Reticulum Cell | 3 |
Femoral, Myelofibrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 5| 7| 6| 7| 7| 5| 7| 6| 6| 7| 3|
DAY ON TEST | 7| 3| 3| 3| 3| 5| 1| 3| 1| 3| 4| 5| 1| 3| 7| 1| 5| 3| 3| 9| 3| 6| 8| 3| 8|
| 8| 2| 1| 3| 1| 5| 5| 2| 7| 3| 3| 2| 1| 1| 8| 2| 2| 3| 2| 5| 3| 8| 8| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Vertebral, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Plasma Cell | 3|
Mandibular, Pigmentation, Hemosiderin| 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | M + M M M M M M M M M + M M M M + M M + M M M M M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 4 2 2 2 2 2 2 2 2 2 2 2 |
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3|
__________________________________________________________________________|
Thymus | + + M + + + + + + M + + + + + + + M M + + M + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 4 2 4 2 2 1 2 3 2 3 2 3 3 2 2 2 2 2 2 2 3 4 2 3 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | X |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X X |
Hydrocephalus | 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
White Matter, Degeneration | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 2 |
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Granuloma | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 1 2 2 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 6| 7| 7| 5| 7| 6| 7| 7| 5| 7| 6| 6| 7| 3|
DAY ON TEST | 7| 3| 3| 3| 3| 5| 1| 3| 1| 3| 4| 5| 1| 3| 7| 1| 5| 3| 3| 9| 3| 6| 8| 3| 8|
| 8| 2| 1| 3| 1| 5| 5| 2| 7| 3| 3| 2| 1| 1| 8| 2| 2| 3| 2| 5| 3| 8| 8| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Inflammation, Chronic Active | |
Mineralization | 2 |
Nephropathy, Chronic | 2 1 2 2 4 1 2 2 1 2 2 1 1 1 1 1 2 1 3 1 2 2 |
__________________________________________________________________________|
Ureter | + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| |
| 3| 3| 2| 1| 1| 1| 5| 2| 2| 6| 3| 3| 3| 3| 1| 1| 2| 5| 1| 3| 2| 2| 1| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 4.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X| 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + M + + +| 46 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 37 |
Degeneration, Cystic | 2 | 2 2.5|
Hepatodiaphragmatic Nodule | X X X | 5 |
Inflammation, Chronic | 2 1 1 2 2 1 2 2 1 1 1 2 1 2 2 1 | 29 1.5|
Necrosis, Coagulative | 4 | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 1 3 2| 10 1.7|
Duct, Ectasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 3 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2| 48 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| |
| 3| 3| 2| 1| 1| 1| 5| 2| 2| 6| 3| 3| 3| 3| 1| 1| 2| 5| 1| 3| 2| 2| 1| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | | 1 1.0|
Atrium, Thrombosis | X | 1 |
Valve, Bacterium | X | 1 |
Valve, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 1 |
Degeneration, Fatty | 1 2 1 1 3 2 1 1 1 | 16 1.5|
Hyperplasia | 3 2 2 2 2 2 2 2 2 1 | 18 1.8|
Hypertrophy | 2 1 1 2 1 | 8 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 6 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + M + + + + M + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 2 3 2 2 2| 6 2.2|
Pars Distalis, Cyst | X X X X X X X X X X X X X X X X X | 25 |
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 2| 12 2.1|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 1 2 2 2 2 2 2 | 14 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 3 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + +| 26 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 2 3 2 | 6 2.5|
Diverticulum | 4 | 1 4.0|
Hemorrhage | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| |
| 3| 3| 2| 1| 1| 1| 5| 2| 2| 6| 3| 3| 3| 3| 1| 1| 2| 5| 1| 3| 2| 2| 1| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cervix, Fibrosis | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 2 2 2 1 1 1 | 14 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia | | 1 4.0|
Femoral, Hyperplasia, Reticulum Cell | 3 2 | 3 2.7|
Femoral, Myelofibrosis | | 1 2.0|
Vertebral, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Hyperplasia, Plasma Cell | | 1 3.0|
Mandibular, Pigmentation, Hemosiderin| | 1 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 37 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M M M M M M M M M M + M M M M M + M M M M M M M| 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 3 2 2 2 2 2 3 2 | 32 2.1|
Pigmentation, Hemosiderin | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 | 32 2.1|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + M + + + + + + M M + + + + + + +| 41 |
Cyst | X X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 2 2 3 3 2 4 3 3 2 2 3 3 2 2 2 2 2 2 2 2 2 3| 48 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Fibrous Osteodystrophy | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X | 13 |
Hydrocephalus | | 2 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | M + + M + + + + + + + + + + + + M M + + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| |
| 3| 3| 2| 1| 1| 1| 5| 2| 2| 6| 3| 3| 3| 3| 1| 1| 2| 5| 1| 3| 2| 2| 1| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
White Matter, Degeneration | 1 1 1 1 | 11 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma | 2 2 1 2 | 5 1.8|
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Nasolacrimal Duct, Granuloma | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 2 2 3 2 2 2 2 2 2 2 2 | 20 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + | 6 |
Lens, Cataract | 4 4 4 3 4 | 5 3.8|
Retina, Atrophy | 4 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | X | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | | 1 2.0|
Nephropathy, Chronic | 1 1 2 2 2 2 2 2 2 2 2 3 2 2 1 1 3 2 2 1 2 1| 44 1.8|
__________________________________________________________________________|____________|
Ureter | + + + + + + + | 17 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3|
| 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + A A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | |
Degeneration, Cystic | 3 1 2 1 1 |
Fatty Change | 4 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 2 |
Inflammation, Necrotizing | 4 |
Mineralization | 2 |
Necrosis, Coagulative | 4 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 2 2 2 2 4 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Mineralization | |
Mesenteric Artery, Intima, | |
Proliferation | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 3 2 2 3 2 2 3 2 2 2 2 2 2 3 3 2 2 2 2 1 2 2 2|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3|
| 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Infarct | |
Mineralization | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 3 1 1 |
Hyperplasia | 2 2 2|
Hypertrophy | 2 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 1 2 2 1 2|
Pars Distalis, Pigmentation, | |
Hemosiderin | |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
C-Cell, Hyperplasia | 1 2 2 1 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 4 2 2 1 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic Active | 3 1 2 2 2 4 2 2 3 4 2 3 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3|
| 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 1 1 1 1 1 1 1 1|
Interstitial Cell, Hyperplasia | 2 2 2 1 1 2 2 1 1 |
Seminiferous Tubule, Atrophy | 3 4 4 4 3 3 4 2 4 2 4 3 4 3 3 2 4 4 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia | 3 |
Femoral, Hyperplasia, Reticulum Cell | 2 |
Vertebral, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Pigmentation, Hemosiderin | 2 |
Mandibular, Cyst | X X |
Mandibular, Hyperplasia, Plasma Cell | 3 3 2 |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Renal, Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + M M M M + M M + M + M M + M + M M M M M M|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Hematopoietic Cell Proliferation | 2 3 2 4 1 2 2 2 1 2 3|
Infiltration Cellular, Lipocyte | 2 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Thymus | + + M + M + + + M + + + + + + + M + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + + + + M + M + + + M + + + M + + + + M|
Hyperplasia, Cystic | 4 1 1 2 3 2 2 4 2 2 3 1 4 2 4 3 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
Vertebra, Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3|
| 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Hemorrhage | 2 2 3 |
Hydrocephalus | 4 3 |
Inflammation, Chronic | 2 |
Pigmentation, Hemosiderin | 2 |
White Matter, Degeneration | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 2 |
White Matter, Degeneration | 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 |
Mineralization | |
Alveolar Epithelium, Hyperplasia, | |
Adenomatous | 3 |
Artery, Mediastinum, Necrosis, | |
Fibrinoid | 2 |
Mediastinum, Inflammation, Chronic | |
Active | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 4 3 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | I |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X|
Hydronephrosis | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 6| 5| 5| 7| 7| 5| 6| 4| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 6| 3| 3| 9| 2| 8| 1| 3| 3| 9| 5| 1| 9| 7| 3| 3| 3|
| 3| 3| 1| 8| 1| 1| 2| 3| 7| 7| 2| 0| 4| 9| 5| 1| 1| 3| 5| 0| 5| 4| 3| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 2 |
Nephropathy, Chronic | 3 2 3 2 4 4 3 4 2 4 3 2 3 3 4 4 4 3 2 3 4 4 3 4 2|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urethra | + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3| |
| 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Necrotizing | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + A + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X| 3 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X | 7 |
Clear Cell Focus | X | 1 |
Degeneration, Cystic | 2 2 1 1 2 | 10 1.6|
Fatty Change | 2 | 2 3.0|
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Chronic | 1 | 3 1.3|
Inflammation, Necrotizing | | 1 4.0|
Mineralization | | 1 2.0|
Necrosis, Coagulative | 2 | 2 3.0|
Vacuolization Cytoplasmic | 2| 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Acinus, Atrophy | 1 1 1 2 2 1 1 2 1 | 15 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 | 1 2.0|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3| |
| 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Mesenteric Artery, Mineralization | 2 | 1 2.0|
Mesenteric Artery, Intima, | | |
Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 3 2 2 3 2 2 2 2 2 2 3 2 3 2 2 2 2 2 2 2 2 3 2 2| 48 2.2|
Infarct | 4 | 1 4.0|
Mineralization | 3 1 1 | 3 1.7|
Atrium, Thrombosis | X X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 1 2 2 | 8 1.8|
Hyperplasia | 1 2 2 2 3 2 2 | 10 2.0|
Hypertrophy | | 1 2.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Angiectasis | | 1 2.0|
Hyperplasia | 2 1 2 2 1 2 2 2 2 | 13 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X X | 4 |
Pars Distalis, Hyperplasia | 2 2 2 2 1 2 2 2 | 18 1.8|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 1 | 1 1.0|
Pars Intermedia, Cyst | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 2.0|
C-Cell, Hyperplasia | 2 2 2 1 | 9 1.7|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + +| 36 |
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3| |
| 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ductus Deferens | + + + + + + +| 15 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | + + | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 4 | 1 4.0|
Inflammation, Chronic Active | 1 1 1 2 2 1 2 1 1 1 2 2 1 2 2 1 1 2 2 4 1 2 2| 42 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Inflammation, Chronic Active | 2 2 2 1 2 2 2 2 1 2 1 2 2| 29 2.1|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 2 1 1 1 1 | 17 1.2|
Interstitial Cell, Hyperplasia | 2 2 2 2 1 1 2 2 1 1 1 1 1 2 2 1| 25 1.5|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 | 40 3.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia | | 1 3.0|
Femoral, Hyperplasia, Reticulum Cell | | 1 2.0|
Vertebral, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchial, Pigmentation, Hemosiderin | 1 2 | 3 1.7|
Mandibular, Cyst | X X | 4 |
Mandibular, Hyperplasia, Plasma Cell | | 3 2.7|
Mediastinal, Hemorrhage | 4 | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 | 1 2.0|
Renal, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M M M M M M M + M M M + M M M M + M + + + M + M| 15 |
Hemorrhage | 3 | 2 2.5|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 2 2 2| 5 2.2|
Hematopoietic Cell Proliferation | 2 2 1 2 2 2 2 | 18 2.1|
Infiltration Cellular, Lipocyte | | 1 2.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3| |
| 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + M M + M + + + + M M + + + + + M M M + + M| 37 |
Cyst | X X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + M + + + M + + + + + + M M + + +| 37 |
Hyperplasia, Cystic | 2 2 1 2 1 1 2 2 2 2 1 2 2 2 2 1 1 2 2| 37 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | X | 1 |
Femur, Fibrous Osteodystrophy | X | 1 |
Vertebra, Fibrous Osteodystrophy | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Compression | X | 4 |
Hemorrhage | | 3 2.3|
Hydrocephalus | | 2 3.5|
Inflammation, Chronic | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
White Matter, Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | M + + + + + + + M + + + M M + + + M + M + + + + +| 43 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | | 1 2.0|
White Matter, Degeneration | 2 2 1 1 1 1 1 2 1 1 1 1 1 1| 19 1.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 1 | 4 2.3|
Mineralization | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Adenomatous | 2 2 | 3 2.3|
Artery, Mediastinum, Necrosis, | | |
Fibrinoid | | 1 2.0|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| |
DAY ON TEST | 3| 2| 3| 1| 3| 3| 3| 3| 5| 3| 1| 3| 1| 3| 3| 3| 3| 3| 2| 7| 3| 8| 3| 2| 3| |
| 1| 2| 3| 1| 2| 2| 3| 2| 4| 2| 9| 1| 9| 1| 1| 1| 1| 1| 5| 6| 3| 8| 3| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 | 4 2.3|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 2 2 2 2 2 2 1 3 1 2 1| 15 2.1|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 3 |
Lens, Cataract | 3 | 1 3.0|
Retina, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 8 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 6 |
Hydronephrosis | 4 | 1 4.0|
Mineralization | | 1 2.0|
Nephropathy, Chronic | 3 2 3 4 3 3 4 4 2 4 3 4 4 4 2 4 3 3 3 4 4 4 4 3 4| 50 3.3|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + + + + + + + | 35 |
__________________________________________________________________________|____________|
Urethra | + + + + + + + | 18 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 5| 7| 6| 5| 4| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 4|
DAY ON TEST | 3| 4| 5| 3| 3| 6| 3| 9| 7| 2| 0| 2| 1| 4| 1| 3| 3| 9| 7| 3| 7| 3| 3| 3| 0|
| 3| 9| 5| 2| 2| 1| 2| 5| 5| 1| 0| 2| 5| 1| 5| 2| 2| 0| 6| 1| 7| 1| 2| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + +|
Foreign Body | 3 |
__________________________________________________________________________|
Intestine Large | + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + +|
Inflammation, Chronic Active | 4|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + A + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 3 2 1 2 2 |
Hepatodiaphragmatic Nodule | X|
Inflammation, Chronic | 1 2 2 |
Leukocytosis | X |
Necrosis, Coagulative | 3|
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
__________________________________________________________________________|
Pancreas | + + A + + + + + + + + A|
Cyst | X |
Acinus, Atrophy | 2 3 2 1 2 1 |
Artery, Inflammation, Proliferative | 3 4 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + A + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + +|
Inflammation, Chronic Active | 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + A|
__________________________________________________________________________|
Tooth | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 2 3 3|
Atrium, Thrombosis | X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 5| 7| 6| 5| 4| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 4|
DAY ON TEST | 3| 4| 5| 3| 3| 6| 3| 9| 7| 2| 0| 2| 1| 4| 1| 3| 3| 9| 7| 3| 7| 3| 3| 3| 0|
| 3| 9| 5| 2| 2| 1| 2| 5| 5| 1| 0| 2| 5| 1| 5| 2| 2| 0| 6| 1| 7| 1| 2| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 1 2 2 2 |
Hypertrophy | 2 2 |
Mineralization | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X |
Hyperplasia | 3 1 2 2 1 2 3 2 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + A + + + + + A|
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | M M + + + + + + M + + + + + + I|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + A + + + + + + + A|
C-Cell, Hyperplasia | 1 1 2 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + |
__________________________________________________________________________|
Ductus Deferens | + + + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + +|
Inflammation, Chronic Active | 2 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + +|
Inflammation, Chronic Active | 3 3 2 2 3 2 4 4|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
Mineralization | 1 1 1 1 1 1 |
Interstitial Cell, Hyperplasia | 1 2 1 2 2 2 2 2 1 2 1 |
Perivascular, Atrophy | |
Rete Testes, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 4 3 3 4 4 4 4 1 4 2 4 2 4 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + +|
Femoral, Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Plasma Cell | |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 5| 7| 6| 5| 4| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 4|
DAY ON TEST | 3| 4| 5| 3| 3| 6| 3| 9| 7| 2| 0| 2| 1| 4| 1| 3| 3| 9| 7| 3| 7| 3| 3| 3| 0|
| 3| 9| 5| 2| 2| 1| 2| 5| 5| 1| 0| 2| 5| 1| 5| 2| 2| 0| 6| 1| 7| 1| 2| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Inflammation, Chronic | |
Active | 4|
__________________________________________________________________________|
Lymph Node, Mesenteric | M M + M + + M M + M + M + M|
Cyst | X |
Inflammation, Proliferative | 4 |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + A|
Fibrosis | 2 2 1 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + M + M +|
Hyperplasia, Cystic | 2 2 3 4 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + +|
Compression | X X |
Hemorrhage | |
Hydrocephalus | 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + M + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + A|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + +|
Bacterium | X|
Granuloma | 2 2 |
Inflammation, Chronic Active | 2 4|
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia, | |
Adenomatous | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2|
__________________________________________________________________________|
Trachea | + + A + + + + + +|
Inflammation, Chronic Active | 4|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 7| 5| 5| 7| 7| 5| 7| 6| 5| 4| 6| 7| 5| 6| 5| 7| 7| 6| 6| 7| 6| 7| 7| 7| 4|
DAY ON TEST | 3| 4| 5| 3| 3| 6| 3| 9| 7| 2| 0| 2| 1| 4| 1| 3| 3| 9| 7| 3| 7| 3| 3| 3| 0|
| 3| 9| 5| 2| 2| 1| 2| 5| 5| 1| 0| 2| 5| 1| 5| 2| 2| 0| 6| 1| 7| 1| 2| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
6 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + + + |
Hemorrhage | |
Lens, Cataract | 2 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + M + + + M + M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + A + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Chronic | |
Nephropathy, Chronic | 4 1 2 4 4 4 3 2 4 4 3 3 4 4 4 4 4 1|
__________________________________________________________________________|
Ureter | + + A + + + + |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + +|
Inflammation, Chronic Active | 4 2 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 5| 6| 3| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 0| 0| 3| 0| 9| 4| 7| 2| 3| 3| 8| 0| 3| 3| 3| 9| 9| 3| 3| 9| 3| 3| |
| 6| 1| 3| 8| 8| 3| 0| 6| 1| 9| 6| 1| 2| 4| 9| 2| 2| 3| 6| 2| 2| 1| 7| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 16 |
Foreign Body | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A A | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 15 |
Inflammation, Chronic Active | | 1 4.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X| 14 |
Clear Cell Focus | | 1 |
Degeneration, Cystic | 2 2 1 | 8 1.9|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic | 1 1 1 1 | 7 1.3|
Leukocytosis | | 1 |
Necrosis, Coagulative | 3 | 2 3.0|
Vacuolization Cytoplasmic | 1 3 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 17 |
Cyst | | 1 |
Acinus, Atrophy | 1 1 3 | 9 1.8|
Artery, Inflammation, Proliferative | | 3 3.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + M + | 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 15 |
Inflammation, Chronic Active | 3 | 2 3.5|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 21 |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 | 16 2.1|
Atrium, Thrombosis | X X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 5| 6| 3| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 0| 0| 3| 0| 9| 4| 7| 2| 3| 3| 8| 0| 3| 3| 3| 9| 9| 3| 3| 9| 3| 3| |
| 6| 1| 3| 8| 8| 3| 0| 6| 1| 9| 6| 1| 2| 4| 9| 2| 2| 3| 6| 2| 2| 1| 7| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 2 1 2 1 2 | 12 1.8|
Hyperplasia | 2 2 2 2 2 | 10 1.9|
Hypertrophy | | 2 2.0|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | | 1 |
Hyperplasia | 2 2 2 2 2 1 3 2 2 2 2 2 2| 24 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 14 |
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + | 14 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + +| 23 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 3| 3 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M + + | 17 |
C-Cell, Hyperplasia | 2 2 | 5 1.6|
Follicular Cell, Hyperplasia | 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Ductus Deferens | + + | 6 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 17 |
Inflammation, Chronic Active | 2 2 2 2 2 2 1 | 16 1.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 19 |
Inflammation, Chronic Active | 4 3 2 3 2 2 | 14 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 16 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 2 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 19 1.0|
Interstitial Cell, Hyperplasia | 1 1 2 2 1 2 1 2 2 2 1 1 1 1 2 1 1| 28 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 5| 6| 3| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 0| 0| 3| 0| 9| 4| 7| 2| 3| 3| 8| 0| 3| 3| 3| 9| 9| 3| 3| 9| 3| 3| |
| 6| 1| 3| 8| 8| 3| 0| 6| 1| 9| 6| 1| 2| 4| 9| 2| 2| 3| 6| 2| 2| 1| 7| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Perivascular, Atrophy | 4 | 1 4.0|
Rete Testes, Hyperplasia | | 1 2.0|
Seminiferous Tubule, Atrophy | 4 4 4 1 4 4 4 4 4 4 4 2 4 4 4 4 4 4 4 4 4| 40 3.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 16 |
Femoral, Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 25 |
Mandibular, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Mediastinal, Inflammation, Chronic | | |
Active | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M M M M M M | 6 |
Cyst | | 1 |
Inflammation, Proliferative | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrosis | 2 2 3 1 2 2 | 10 1.8|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + | 14 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 15 |
Hyperplasia, Cystic | 2 4 1 2 2 1 4 | 12 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 25 |
Cyst Epithelial Inclusion | X | 1 |
Inflammation, Chronic Active | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 16 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 16 |
Compression | X X | 4 |
Hemorrhage | 3 | 1 3.0|
Hydrocephalus | 3 3 4 | 5 2.8|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + | 15 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 5| 6| 3| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 3| 3| 0| 0| 3| 0| 9| 4| 7| 2| 3| 3| 8| 0| 3| 3| 3| 9| 9| 3| 3| 9| 3| 3| |
| 6| 1| 3| 8| 8| 3| 0| 6| 1| 9| 6| 1| 2| 4| 9| 2| 2| 3| 6| 2| 2| 1| 7| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
6 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 17 |
Bacterium | | 1 |
Granuloma | | 2 2.0|
Inflammation, Chronic Active | | 2 3.0|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Adenomatous | 4 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 16 |
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 15 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Hemorrhage | 3 | 1 3.0|
Lens, Cataract | | 1 2.0|
Retina, Atrophy | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + M + + + | 12 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + | 36 |
Cyst | X X X X X | 8 |
Inflammation, Chronic | 3 | 1 3.0|
Nephropathy, Chronic | 4 3 3 3 4 4 1 3 4 3 2 4 4 3 2 2 4 4 | 36 3.2|
__________________________________________________________________________|____________|
Ureter | + + + + + + | 12 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 18 |
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 3| 7| 7| 6| 7| 4|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 0| 9| 2| 3| 3| 3| 4| 2| 6| 3| 3| 5| 1| 2|
| 3| 1| 1| 3| 3| 3| 1| 2| 3| 5| 2| 8| 5| 6| 3| 2| 1| 8| 2| 7| 2| 1| 5| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | |
Clear Cell Focus, Multiple | |
Degeneration, Cystic | 1 2 1 1 1 1 2 3 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 1 1 1 1 1 1 |
Mineralization | |
Necrosis, Coagulative | 3 2 4 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | |
Acinus, Atrophy | 2 1 1 1 1 2 1 2 2 2 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
Pulmonary Artery, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 3 2 2 2 2 2 3 2 2 2 3 2 3 2 3 3 3 2 3 2 3 2 2|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 3| 7| 7| 6| 7| 4|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 0| 9| 2| 3| 3| 3| 4| 2| 6| 3| 3| 5| 1| 2|
| 3| 1| 1| 3| 3| 3| 1| 2| 3| 5| 2| 8| 5| 6| 3| 2| 1| 8| 2| 7| 2| 1| 5| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | 2 2 1 2 1 |
Hyperplasia | 2 1 2 1 2 1 2 1 |
Hypertrophy | 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 2 2 3 2 |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + M + M + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 2 1 1 2 1 2 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ductus Deferens | + + + + + + + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Inflammation, Chronic | 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 2 2 2 1 1 2 1 2 2 2 1 2 1 3 2 1 1 1 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Inflammation, Chronic Active | 1 2 4 2 2 1 2 3 2 2 1 2 3 1 2 4 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 |
Interstitial Cell, Hyperplasia | 1 1 1 2 1 2 1 2 2 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 3| 7| 7| 6| 7| 4|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 0| 9| 2| 3| 3| 3| 4| 2| 6| 3| 3| 5| 1| 2|
| 3| 1| 1| 3| 3| 3| 1| 2| 3| 5| 2| 8| 5| 6| 3| 2| 1| 8| 2| 7| 2| 1| 5| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | 1 |
Femoral, Myelofibrosis | |
Vertebral, Hyperplasia, Reticulum | |
Cell | 1 |
Vertebral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Pigmentation, Hemosiderin | |
Mandibular, Cyst | X |
Mandibular, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 |
Renal, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M M M M + M M + M M M M M M M + M M M M M M + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 3 4 |
Hematopoietic Cell Proliferation | 3 2 2 2 |
Infarct | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + M + M + M M + + + + + M M + M + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + M M + + M + + + + + + + M M +|
Hyperplasia, Cystic | 2 3 2 1 4 1 2 2 4 2 1 1 4 2 1 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
Vertebra, Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X|
Hemorrhage | |
Hydrocephalus | 3 2 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 3| 7| 7| 6| 7| 4|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 0| 9| 2| 3| 3| 3| 4| 2| 6| 3| 3| 5| 1| 2|
| 3| 1| 1| 3| 3| 3| 1| 2| 3| 5| 2| 8| 5| 6| 3| 2| 1| 8| 2| 7| 2| 1| 5| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
White Matter, Degeneration | 1 1 1 1 1 2 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolar Epithelium, Hyperplasia, | |
Adenomatous | |
Artery, Mediastinum, Necrosis, | |
Fibrinoid | |
Interstitium, Inflammation, Chronic | 2 3 1 |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 3 2 2 2 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Hemorrhage | |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Nephropathy, Chronic | 2 4 4 4 3 3 3 3 4 3 3 4 3 2 3 4 4 4 4 1 3 3 3 4 2|
__________________________________________________________________________|
Ureter | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3| |
| 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X| 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X | 5 |
Clear Cell Focus | X | 1 |
Clear Cell Focus, Multiple | X | 1 |
Degeneration, Cystic | 1 2 2 1 4 1 2 2 4 2 2| 19 1.8|
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation, Chronic | 2 | 7 1.1|
Mineralization | 2 | 1 2.0|
Necrosis, Coagulative | 3 | 5 3.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation, Hemosiderin | 2 | 1 2.0|
Acinus, Atrophy | 1 1 1 1 | 15 1.4|
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3| |
| 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Aorta, Mineralization | 3 | 1 3.0|
Pulmonary Artery, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 3 3 3 3 2 2 2 2 2 3 2 2 3 3 2 3 3 3 3 2 3 2 2 3| 48 2.5|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 1 |
Degeneration, Fatty | 1 1 3 2 | 9 1.7|
Hyperplasia | 2 1 2 2 2 2 2 | 15 1.7|
Hypertrophy | 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 2 2 2 2 2 | 16 1.9|
Necrosis, Coagulative | 3 | 2 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + M| 45 |
Hyperplasia | 3 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 2 1 3 2 2 2 | 15 1.8|
Pars Intermedia, Angiectasis | 2 | 1 2.0|
Pars Intermedia, Cyst | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 1 2 2 2 2 2 2 2 | 17 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + + + + + + + + + + + + + | 32 |
__________________________________________________________________________|____________|
Ductus Deferens | + + + + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3| |
| 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | 1 1 1 1 2 1 2 3 2 1 2 1 2 1 2 2 2 2 2 1 2 | 42 1.6|
__________________________________________________________________________|____________|
Prostate | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 1.0|
Inflammation, Chronic Active | 2 4 2 3 1 2 2 1 1 2 2 1 3 | 30 2.1|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 | 10 1.0|
Interstitial Cell, Hyperplasia | 2 1 2 1 2 2 2 1 2 2 3 1 2| 27 1.7|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4| 46 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia, Reticulum Cell | | 1 1.0|
Femoral, Myelofibrosis | 4 | 1 4.0|
Vertebral, Hyperplasia, Reticulum | | |
Cell | | 1 1.0|
Vertebral, Myelofibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchial, Pigmentation, Hemosiderin | 3 | 1 3.0|
Mandibular, Cyst | | 1 |
Mandibular, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 | 2 1.5|
Renal, Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M M M + M M M M M M + M + M M M M + M M M M M M| 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 2 2 2 | 9 2.6|
Hematopoietic Cell Proliferation | 2 2 2 2| 8 2.1|
Infarct | 3 | 1 3.0|
Pigmentation, Hemosiderin | 3 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | M + M + M M M M + + + + + + + + + + + + + + + M +| 35 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + M + + + M + + + + + + M + + + + + + M +| 39 |
Hyperplasia, Cystic | 2 4 2 3 3 2 2 3 1 1 1 2 2 2 1 2 1 4 2| 36 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3| |
| 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | X X | 2 |
Femur, Fibrous Osteodystrophy | X X | 2 |
Vertebra, Fibrous Osteodystrophy | X X | 2 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X | 9 |
Hemorrhage | 4 | 1 4.0|
Hydrocephalus | | 2 2.5|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + M + + M + + + + + + + + + + + + M + + + + +| 46 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
White Matter, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 21 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Adenomatous | 3 2 2 | 3 2.3|
Artery, Mediastinum, Necrosis, | | |
Fibrinoid | 2 | 1 2.0|
Interstitium, Inflammation, Chronic | 1 | 4 1.8|
Mediastinum, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 2 3.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 2 2 2 2| 12 1.8|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05024-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC N-METHYLOLACRYLAMIDE Date: 05/05/97
Route: GAVAGE Time: 12:28:08
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 0| 5| 3| 2| 0| 3| 1| 3| 3| 9| 0| 3| 8| 3| 2| 3| 3| 1| 3| 3| 3| 5| 9| 3| |
| 1| 4| 4| 2| 7| 8| 3| 9| 1| 2| 0| 8| 2| 7| 3| 6| 3| 1| 2| 3| 1| 2| 4| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
12 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Hemorrhage | 4 | 1 4.0|
Lens, Cataract | 4 | 2 3.5|
Retina, Atrophy | 4 | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 8 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | +| 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 6 |
Nephropathy, Chronic | 4 2 3 4 2 4 3 3 3 4 4 3 3 2 3 3 3 3 4 4 3 3 4 2 3| 50 3.2|
__________________________________________________________________________|____________|
Ureter | + + + + + + + + + + + + + + +| 36 |
__________________________________________________________________________|____________|
Urethra | + + + + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
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