TDMS Study 05024-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/04/94
EXP: 05024 N-METHYLOLACRYLAMIDE TIME: 03:30:58
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60333
CONT: NO1CP9565302 CAS: 924-42-5
PATHOLOGIST: J. TOFT S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/04/94
EXP: 05024 N-METHYLOLACRYLAMIDE TIME: 03:30:58
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60333
CONT: NO1CP9565302 CAS: 924-42-5
PATHOLOGIST: J. TOFT S. EUSTIS
N-METHYLOLACRYLAMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 410 422 515 531 554 589 593 624 627 637 |
| 655 667 674 676 688 690 695 708 711 719 |
| 719 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 6 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 379 408 421 492 509 515 515 549 555 561 |
| 575 596 596 600 600 608 641 641 676 677 |
| 684 690 695 697 708 722 726 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 12 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 367 425 487 548 555 573 604 627 654 654 |
| 655 690 695 695 708 708 708 712 712 719 |
| 722 726 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
N-METHYLOLACRYLAMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 96.0 96.0 92.0 86.0 78.0 56.0 |
|CONTROL | |
| | |
|6 MG/KG | 100.0 100.0 100.0 100.0 94.0 94.0 86.0 70.0 64.0 44.0 |
| | |
| | |
|12 MG/KG | 100.0 100.0 100.0 100.0 96.0 96.0 94.0 86.0 78.0 54.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 6 MG/KG 12 MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.0% 44.0% 54.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.226 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 628.6 598.6 637.8 |
|NATURAL DEATHS (C) | (19.6) (18.8) (21.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 685.9 656.9 688.1 |
|(STANDARD ERROR) | (11.2) (14.0) (11.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
N-METHYLOLACRYLAMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 351 381 529 578 613 639 656 676 676 698 |
| 702 702 702 718 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 6 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 119 296 423 443 443 458 508 532 535 549 |
| 550 575 575 590 612 626 641 644 656 667 |
| 668 668 684 688 698 711 715 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 12 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 383 443 555 578 578 595 617 625 652 652 |
| 668 688 711 712 715 715 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
N-METHYLOLACRYLAMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 98.0 96.0 96.0 94.0 92.0 86.0 70.0 |
|CONTROL | |
| | |
|6 MG/KG | 100.0 98.0 98.0 96.0 94.0 88.0 82.0 72.0 62.0 44.0 |
| | |
| | |
|12 MG/KG | 100.0 100.0 100.0 100.0 98.0 96.0 96.0 88.0 80.0 66.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 6 MG/KG 12 MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 44.0% 66.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.747 P=0.007 P=0.788 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 623.1 571.4 624.3 |
|NATURAL DEATHS (C) | (30.4) (26.0) (23.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 698.6 641.6 694.7 |
|(STANDARD ERROR) | (11.4) (18.4) (10.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
N-METHYLOLACRYLAMIDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
6 MG/KG = 2
12 MG/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 2 1 1
| 2 1 32 1 1 3
| 2 2 1 31
P 90 + 22 1 3 1
E | 3 3
R | 2 22 1 3 1 3
C | 22 11
E 80 + 2 2 1 1
N | 2 2 1 1 3
T | 11 33
| 1 13 3
S 70 + 22
U | 2 2 11
R | 2 2 1 1
V | 11
I 60 + 22 33
V | 22 11
A | 22 1 1
L | 2 2
50 + 2 2
|
| 2 2
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 19 obs hidden.
N-METHYLOLACRYLAMIDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
6 MG/KG = 2
12 MG/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 2 1 3
| 2 2 1 1 3
96 + 2 1 2 3 1 3
| 2 2 1 3 1
| 1 1
| 2 2 3 3 1 1
P 88 + 2 2 3 3 1 1
E | 2 2 33 1 1
R | 22 3 3
C | 2 2 1 1
E 80 + 3 3 11
N | 2 2 3 3
T | 3 3
| 2 2 1 1
S 72 + 2 2 311
U | 2 2 1 1
R | 2 2 33
V | 3 3
I 64 + 2 2
V | 2 2
A |
L |
56 + 2 2
| 22
| 22
| 2 2
48 + 22
| 22
| 2 2
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
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