TDMS Study 05025-01 Pathology Tables
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
Facility: Southern Research Institute
Chemical CAS #: 107-21-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 5| 6| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 9| 3| 6| 3| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 7| 9| 3| 3| 0| 3|
| 1| 1| 1| 1| 5| 7| 1| 5| 6| 6| 8| 6| 6| 6| 6| 2| 6| 6| 6| 4| 6| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + M + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + M + A + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + M + A + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoid Tissue, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + M + A + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoid Tissue, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + M + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 5| 6| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 9| 3| 6| 3| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 7| 9| 3| 3| 0| 3|
| 1| 1| 1| 1| 5| 7| 1| 5| 6| 6| 8| 6| 6| 6| 6| 2| 6| 6| 6| 4| 6| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Capsule, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma, Papillary | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Oviduct | + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X|
Endometrium, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 5| 6| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 9| 3| 6| 3| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 7| 9| 3| 3| 0| 3|
| 1| 1| 1| 1| 5| 7| 1| 5| 6| 6| 8| 6| 6| 6| 6| 2| 6| 6| 6| 4| 6| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X X|
Mesenteric, Lymphoma Malignant | |
Lymphocytic | |
Mesenteric, Lymphoma Malignant Mixed | X X X|
Mesenteric, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Pancreatic, Lymphoma Malignant Mixed | X X|
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + M + + + M + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + A + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Undifferentiated | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 5| 6| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 9| 3| 6| 3| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 7| 9| 3| 3| 0| 3|
| 1| 1| 1| 1| 5| 7| 1| 5| 6| 6| 8| 6| 6| 6| 6| 2| 6| 6| 6| 4| 6| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Cell Type | X |
Back, Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Multiple, | |
Metastatic, Greater Than Five, | |
Liver | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + +|
Adenoma | X X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3|
| 6| 6| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 8| 7| 7| 7| 7| 1| 7| 7| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoid Tissue, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoid Tissue, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X X X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3|
| 6| 6| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 8| 7| 7| 7| 7| 1| 7| 7| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X X X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Capsule, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X|
Pars Distalis, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + M + + + + + + + + + + + +|
Cystadenoma, Papillary | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Oviduct | + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
Endometrium, Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3|
| 6| 6| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 8| 7| 7| 7| 7| 1| 7| 7| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X X |
Mediastinal, Lymphoma Malignant Mixed| |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X X X |
Mesenteric, Lymphoma Malignant Mixed | X X X X |
Mesenteric, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + M + + + + + + + M M + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + M M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Undifferentiated | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3|
| 6| 6| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 8| 7| 7| 7| 7| 1| 7| 7| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Cell Type | |
Back, Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Multiple, | |
Metastatic, Greater Than Five, | |
Liver | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 48 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Intestine Small | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 47 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 47 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoid Tissue, Lymphoma Malignant | | |
Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 47 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoid Tissue, Lymphoma Malignant | | |
Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hepatocellular Carcinoma | | 3 |
Hepatocellular Adenoma | | 8 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 17 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Capsule, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 48 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Pars Distalis, Adenoma | | 17 |
Pars Distalis, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 49 |
Cystadenoma, Papillary | | 2 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Oviduct | | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
Endometrium, Polyp Stromal | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | | 3 |
Mesenteric, Lymphoma Malignant Mixed | | 7 |
Mesenteric, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Pancreatic, Lymphoma Malignant Mixed | | 3 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 43 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | | 49 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 11 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | | 47 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | | 49 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Back, Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Multiple, | | |
Metastatic, Greater Than Five, | | |
Liver | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | | 50 |
Mucosa, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 13 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|
| 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X X X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + M + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|
| 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma, Papillary | X X X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
Teratoma NOS | |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Leiomyosarcoma | X |
Lymphoma Malignant Histiocytic | X |
Endometrium, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| |
Mesenteric, Lymphoma Malignant Mixed | X X X X |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|
| 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Harderian | |
Gland | |
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + M + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | M + + + + + + + + + + + + M + + + + + + + + + + +|
Cystadenoma, Papillary | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Teratoma NOS | X |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Leiomyosarcoma | |
Lymphoma Malignant Histiocytic | |
Endometrium, Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant Mixed| X |
Mesenteric, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoacanthoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
Abdominal, Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Harderian | |
Gland | X |
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 49 |
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hepatocellular Carcinoma | | 3 |
Hepatocellular Adenoma | | 7 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 50 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
__________________________________________________________________________|____________|
Tooth | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Pars Distalis, Adenoma | | 16 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicular Cell, Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 48 |
Cystadenoma, Papillary | | 4 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Teratoma NOS | | 1 |
__________________________________________________________________________|____________|
Oviduct | | 1 |
__________________________________________________________________________|____________|
Uterus | | 50 |
Adenocarcinoma | | 1 |
Leiomyosarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Endometrium, Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Bronchial, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Mesenteric, Lymphoma Malignant Mixed | | 5 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | | 50 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | | 47 |
Lymphoma Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Adenoacanthoma | | 1 |
__________________________________________________________________________|____________|
Skin | | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Abdominal, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Nose | | 50 |
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 1| 6| 6| 6| 1| 6| 6| 6| 4| 6| 6| 6| 6| 7| 8| 9| 0| 6| 6| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Gallbladder | + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X|
Hepatocellular Adenoma | X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 1| 6| 6| 6| 1| 6| 6| 6| 4| 6| 6| 6| 6| 7| 8| 9| 0| 6| 6| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + M + M M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + |
Pars Distalis, Adenoma | X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + |
Cystadenoma, Papillary | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Endometrium, Lymphoma Malignant | |
Histiocytic | |
Endometrium, Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Axillary, Lymphoma Malignant | |
Lymphocytic | X |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | X |
Iliac, Lymphoma Malignant Lymphocytic| X |
Inguinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 1| 6| 6| 6| 1| 6| 6| 6| 4| 6| 6| 6| 6| 7| 8| 9| 0| 6| 6| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphocytic | X |
Mesenteric, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X |
Mesenteric, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
Adenocarcinoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
Osteosarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Harderian | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 1| 6| 6| 6| 1| 6| 6| 6| 4| 6| 6| 6| 6| 7| 8| 9| 0| 6| 6| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Gland | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Nose | + + + + + + + |
Mucosa, Lymphoma Malignant | |
Histiocytic | |
Mucosa, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Trachea | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 6| 7| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 7| 3| 0| 3| 1| 3| 3| 6| 0| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 6| 3| 4|
| 7| 9| 7| 0| 8| 1| 7| 7| 5| 8| 7| 7| 8| 5| 0| 7| 4| 8| 2| 0| 8| 8| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | + + + + A A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A A + + + A A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A A + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A A + + + A A + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small | + + + + A A + + + A A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A A + + + A A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A A + + + A A + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A A + + + A A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X X |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 6| 7| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 7| 3| 0| 3| 1| 3| 3| 6| 0| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 6| 3| 4|
| 7| 9| 7| 0| 8| 1| 7| 7| 5| 8| 7| 7| 8| 5| 0| 7| 4| 8| 2| 0| 8| 8| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + +|
Cystadenoma, Papillary | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Oviduct | + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Endometrium, Lymphoma Malignant | |
Histiocytic | X |
Endometrium, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | |
Iliac, Lymphoma Malignant Lymphocytic| |
Inguinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mediastinal, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 6| 7| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 7| 3| 0| 3| 1| 3| 3| 6| 0| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 6| 3| 4|
| 7| 9| 7| 0| 8| 1| 7| 7| 5| 8| 7| 7| 8| 5| 0| 7| 4| 8| 2| 0| 8| 8| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphocytic | |
Mesenteric, Lymphoma Malignant | |
Histiocytic | X |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X |
Mesenteric, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spleen | + + + + + + M + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | + + + + M M + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + +|
Adenocarcinoma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + +|
Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X|
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Harderian | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 6| 7| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 7| 3| 0| 3| 1| 3| 3| 6| 0| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 6| 3| 4|
| 7| 9| 7| 0| 8| 1| 7| 7| 5| 8| 7| 7| 8| 5| 0| 7| 4| 8| 2| 0| 8| 8| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Gland | X |
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + +|
Mucosa, Lymphoma Malignant | |
Histiocytic | X |
Mucosa, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 21 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Gallbladder | + | 21 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M | 16 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 19 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 17 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M | 16 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M | 16 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Hepatocellular Carcinoma | | 6 |
Hepatocellular Adenoma | | 8 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 15 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 22 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 21 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Stomach | + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 20 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 20 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 21 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 21 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 21 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 21 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | 14 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 23 |
Pars Distalis, Adenoma | | 7 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Lymphoma Malignant Lymphocytic | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 25 |
Cystadenoma, Papillary | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Oviduct | | 4 |
__________________________________________________________________________|____________|
Uterus | + | 45 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Endometrium, Lymphoma Malignant | | |
Histiocytic | | 1 |
Endometrium, Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 21 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Deep Cervical, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Inguinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Mesenteric, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 20 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Spleen | + | 28 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Thymus | + | 19 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 21 |
Adenocarcinoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Skin | + | 40 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + | 21 |
Osteosarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 21 |
Lymphoma Malignant Lymphocytic | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Alveolar/Bronchiolar Adenoma | | 4 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Nose | + | 21 |
Mucosa, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mucosa, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Trachea | + | 21 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Adenoma | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 50 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 21 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 51 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 4 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 5| 5| 7| 4| 7| 5| 7| 7| 6| 5| 7| 7| 6|
DAY ON TEST | 8| 3| 3| 9| 3| 3| 6| 3| 3| 3| 3| 7| 4| 3| 3| 7| 3| 6| 1| 3| 4| 5| 3| 3| 9|
| 8| 6| 6| 6| 6| 6| 3| 6| 6| 9| 6| 9| 3| 5| 6| 2| 6| 1| 8| 6| 4| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + +|
Sarcoma | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Multiple, Metastatic,| |
Ovary | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple, | |
Two | |
Hepatocellular Adenoma | X X |
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + + + |
Adenocarcinoma, Multiple, Metastatic,| |
Ovary | X |
Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + +|
Adenocarcinoma, Metastatic, Ovary | X |
Lymphoma Malignant Mixed | X |
Sarcoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 5| 5| 7| 4| 7| 5| 7| 7| 6| 5| 7| 7| 6|
DAY ON TEST | 8| 3| 3| 9| 3| 3| 6| 3| 3| 3| 3| 7| 4| 3| 3| 7| 3| 6| 1| 3| 4| 5| 3| 3| 9|
| 8| 6| 6| 6| 6| 6| 3| 6| 6| 9| 6| 9| 3| 5| 6| 2| 6| 1| 8| 6| 4| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X|
Pars Distalis, Adenoma | X X|
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Cystadenoma, Papillary | X |
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Endometrium, Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Histiocytic | X|
Axillary, Lymphoma Malignant Mixed | X |
Iliac, Lymphoma Malignant Histiocytic| X|
Iliac, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant | |
Histiocytic | X|
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Adenocarcinoma, | |
Metastatic, Ovary | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X|
Mediastinal, Lymphoma Malignant Mixed| X |
Mesenteric, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 5| 5| 7| 4| 7| 5| 7| 7| 6| 5| 7| 7| 6|
DAY ON TEST | 8| 3| 3| 9| 3| 3| 6| 3| 3| 3| 3| 7| 4| 3| 3| 7| 3| 6| 1| 3| 4| 5| 3| 3| 9|
| 8| 6| 6| 6| 6| 6| 3| 6| 6| 9| 6| 9| 3| 5| 6| 2| 6| 1| 8| 6| 4| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Histiocytic | X|
Mesenteric, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Histiocytic| X|
Renal, Lymphoma Malignant Mixed | X |
Thoracic, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + A + + + + + + + +|
Lymphoma Malignant Histiocytic | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + +|
Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
Osteosarcoma, Metastatic, Bone | |
Neck, Sarcoma | X |
Thoracic, Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Multiple, Metastatic,| |
Greater Than Five, Ovary | X |
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X |
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 5| 5| 7| 4| 7| 5| 7| 7| 6| 5| 7| 7| 6|
DAY ON TEST | 8| 3| 3| 9| 3| 3| 6| 3| 3| 3| 3| 7| 4| 3| 3| 7| 3| 6| 1| 3| 4| 5| 3| 3| 9|
| 8| 6| 6| 6| 6| 6| 3| 6| 6| 9| 6| 9| 3| 5| 6| 2| 6| 1| 8| 6| 4| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 9| 1| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 6| 6| 7| 7| 4| 2| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + M + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
Sarcoma | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Multiple, Metastatic,| |
Ovary | |
Hepatocellular Carcinoma | X X|
Hepatocellular Carcinoma, Multiple, | |
Two | X |
Hepatocellular Adenoma | X X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + |
Adenocarcinoma, Multiple, Metastatic,| |
Ovary | |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
Adenocarcinoma, Metastatic, Ovary | |
Lymphoma Malignant Mixed | |
Sarcoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 9| 1| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 6| 6| 7| 7| 4| 2| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Malignant | X|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Pars Distalis, Adenoma | X X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + |
Adenocarcinoma | |
Cystadenoma, Papillary | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Endometrium, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Axillary, Lymphoma Malignant | |
Histiocytic | |
Axillary, Lymphoma Malignant Mixed | |
Iliac, Lymphoma Malignant Histiocytic| |
Iliac, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant | |
Histiocytic | |
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Adenocarcinoma, | |
Metastatic, Ovary | |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
Mesenteric, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 9| 1| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 6| 6| 7| 7| 4| 2| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Histiocytic | |
Mesenteric, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Mixed | |
Thoracic, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
Osteosarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Osteosarcoma, Metastatic, Bone | X |
Neck, Sarcoma | |
Thoracic, Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Multiple, Metastatic,| |
Greater Than Five, Ovary | |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 9| 1| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 6| 6| 7| 7| 4| 2| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 20 |
__________________________________________________________________________|____________|
Gallbladder | | 18 |
__________________________________________________________________________|____________|
Intestine Large | | 19 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 19 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 19 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 19 |
__________________________________________________________________________|____________|
Intestine Small | | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 19 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 19 |
__________________________________________________________________________|____________|
Liver | | 50 |
Adenocarcinoma, Multiple, Metastatic,| | |
Ovary | | 1 |
Hepatocellular Carcinoma | | 4 |
Hepatocellular Carcinoma, Multiple, | | |
Two | | 1 |
Hepatocellular Adenoma | | 5 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
Adenocarcinoma, Multiple, Metastatic,| | |
Ovary | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | | 21 |
Adenocarcinoma, Metastatic, Ovary | | 1 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | | 20 |
__________________________________________________________________________|____________|
Stomach | | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 20 |
__________________________________________________________________________|____________|
Tooth | | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
__________________________________________________________________________|____________|
Heart | | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 21 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 19 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | | 22 |
Lymphoma Malignant Histiocytic | | 1 |
Pars Distalis, Adenoma | | 5 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 25 |
Adenocarcinoma | | 1 |
Cystadenoma, Papillary | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Uterus | | 45 |
Lymphoma Malignant Histiocytic | | 1 |
Endometrium, Polyp Stromal | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 20 |
__________________________________________________________________________|____________|
Lymph Node | | 24 |
Axillary, Lymphoma Malignant | | |
Histiocytic | | 1 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Iliac, Lymphoma Malignant Histiocytic| | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Lymphoma Malignant Mixed | | 2 |
Inguinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Adenocarcinoma, | | |
Metastatic, Ovary | | 1 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Mesenteric, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mesenteric, Lymphoma Malignant Mixed | | 2 |
Renal, Lymphoma Malignant Histiocytic| | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
Thoracic, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 21 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | | 29 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 6 |
__________________________________________________________________________|____________|
Thymus | | 19 |
Lymphoma Malignant Histiocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 20 |
__________________________________________________________________________|____________|
Skin | | 43 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 20 |
Osteosarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Osteosarcoma, Metastatic, Bone | | 1 |
Neck, Sarcoma | | 1 |
Thoracic, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | | 20 |
Lymphoma Malignant Histiocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Adenocarcinoma, Multiple, Metastatic,| | |
Greater Than Five, Ovary | | 1 |
Alveolar/Bronchiolar Adenoma | | 4 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Nose | | 20 |
__________________________________________________________________________|____________|
Trachea | | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Adenoma | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | | 19 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | | 50 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|
DAY ON TEST | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|
| 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Adenomatous | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X |
Hemangiosarcoma, Multiple, Two | X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X X X X|
Lymphoma Malignant Mixed | X X |
Serosa, Sarcoma | |
__________________________________________________________________________|
Mesentery | + + + |
Cholangiocarcinoma, Metastatic, Liver| X |
Hemangiosarcoma | X |
Lymphoma Malignant Mixed | X |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Benign | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + |
Pulp, Incisor, Lymphoma Malignant | |
Mixed | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|
DAY ON TEST | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|
| 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | |
Capsule, Cholangiocarcinoma, | |
Metastatic, Liver | X |
Capsule, Sarcoma | |
Subcapsular, Adenoma | |
Subcapsular, Adenoma, Multiple | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + M + +|
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + M + + + + + + + + + + + + + +|
Sarcoma | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + M + + + + + + + + + + + + + +|
Sarcoma | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Lymphoma Malignant Mixed | |
Mesenteric, Lymphoma Malignant Mixed | X X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + M + + + + + M + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|
DAY ON TEST | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|
| 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M + M M M M M M M M M M M + M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Benign | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Cholangiocarcinoma, | |
Metastatic, Liver | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple, Greater Than Five | X |
Alveolar/Bronchiolar Carcinoma | X |
Cholangiocarcinoma, Metastatic, Liver| X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma, Metastatic, Liver| X |
Lymphoma Malignant Mixed | X X |
Capsule, Sarcoma | |
Renal Tubule, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|
DAY ON TEST | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|
| 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|
| 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
Sarcoma | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Adenomatous | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | |
Hemangiosarcoma, Multiple, Two | |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Adenoma | X X X X |
Lymphoma Malignant Mixed | X X X X |
Serosa, Sarcoma | X |
__________________________________________________________________________|
Mesentery | + |
Cholangiocarcinoma, Metastatic, Liver| |
Hemangiosarcoma | |
Lymphoma Malignant Mixed | |
Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Benign | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + |
Pulp, Incisor, Lymphoma Malignant | |
Mixed | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|
| 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | X X |
Capsule, Cholangiocarcinoma, | |
Metastatic, Liver | |
Capsule, Sarcoma | X |
Subcapsular, Adenoma | X |
Subcapsular, Adenoma, Multiple | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + M +|
Sarcoma | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Lymphoma Malignant Mixed | X X |
Mesenteric, Lymphoma Malignant Mixed | X X |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M M M + M + + + + + + + + M +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|
| 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M + M M M M + M M M M + + M M + M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Benign | |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X|
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Diaphragm, Cholangiocarcinoma, | |
Metastatic, Liver | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, | |
Uncertain Primary Site | X |
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple, Greater Than Five | |
Alveolar/Bronchiolar Carcinoma | |
Cholangiocarcinoma, Metastatic, Liver| |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma, Metastatic, Liver| |
Lymphoma Malignant Mixed | X |
Capsule, Sarcoma | X |
Renal Tubule, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|
| 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 4| 4| 4| 4| 6| 4| 4| | |
DAY ON TEST | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6| | |
| 0| 6| 6| 5| 5| 5| 5| 9| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
__________________________________________________________________________|____________|
Gallbladder | M M + + | 51 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 54 |
Polyp Adenomatous | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Cholangiocarcinoma | | 1 |
Hemangiosarcoma, Multiple, Two | | 1 |
Hepatocellular Carcinoma | | 10 |
Hepatocellular Adenoma | | 9 |
Lymphoma Malignant Mixed | | 6 |
Serosa, Sarcoma | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 53 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
Mast Cell Tumor Benign | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
__________________________________________________________________________|____________|
Tooth | + | 21 |
Pulp, Incisor, Lymphoma Malignant | | |
Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 54 |
Adenocarcinoma, Metastatic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 4| 4| 4| 4| 6| 4| 4| | |
DAY ON TEST | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6| | |
| 0| 6| 6| 5| 5| 5| 5| 9| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Uncertain Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 54 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 54 |
Adenoma | | 2 |
Capsule, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
Capsule, Sarcoma | | 1 |
Subcapsular, Adenoma | | 1 |
Subcapsular, Adenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 54 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 53 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 52 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 53 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 54 |
__________________________________________________________________________|____________|
Penis | + | 5 |
__________________________________________________________________________|____________|
Preputial Gland | | 12 |
__________________________________________________________________________|____________|
Prostate | + + + + | 53 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 52 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
Hemangiosarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 4| 4| 4| 4| 6| 4| 4| | |
DAY ON TEST | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6| | |
| 0| 6| 6| 5| 5| 5| 5| 9| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inguinal, Lymphoma Malignant Mixed | | 2 |
Mesenteric, Lymphoma Malignant Mixed | | 4 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M | 45 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + | 54 |
Hemangiosarcoma | | 2 |
Lymphoma Malignant Mixed | | 6 |
__________________________________________________________________________|____________|
Thymus | + + + M | 53 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M | 13 |
__________________________________________________________________________|____________|
Skin | + + + + | 54 |
Mast Cell Tumor Benign | | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Fibrosarcoma | X | 3 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 2 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 54 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Diaphragm, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Adenocarcinoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Alveolar/Bronchiolar Adenoma | | 6 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple, Greater Than Five | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 4| 4| 4| 4| 6| 4| 4| | |
DAY ON TEST | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6| | |
| 0| 6| 6| 5| 5| 5| 5| 9| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + | 54 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 54 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Lymphoma Malignant Mixed | | 3 |
Capsule, Sarcoma | | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 54 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Mixed | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|
| 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + A + + + + M M + + + M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + A A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + + + + A + + + + A A + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoid Tissue, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + A + + + + + + +|
Lymphoma Malignant Mixed | |
Polyp Adenomatous | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple, Two| X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + + + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tooth | + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Adenoma | X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|
| 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Ductus Deferens | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
__________________________________________________________________________|
Penis | + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant Mixed| X |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | |
Mesenteric, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M + + M + + + M M + M + M + M + + M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrosarcoma, | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|
| 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Metastatic, Skin | X |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Sarcoma, | |
Multiple | X |
Subcutaneous Tissue, Schwannoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Fibrosarcoma, Multiple, Metastatic, | |
Skin | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Mediastinum, Fibrosarcoma, | |
Metastatic, Skin | X |
Pleura, Fibrosarcoma, Multiple, | |
Metastatic, Skin | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urethra | + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|
| 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|
| 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + A + + + + + I + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + A + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + A + M + + + M + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + A + M + + + M + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + A + + + + + M M + +|
Lymphoma Malignant Mixed | X |
Lymphoid Tissue, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + A + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Polyp Adenomatous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple, Two| |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tooth | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + M + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + M + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|
| 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Ductus Deferens | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X|
__________________________________________________________________________|
Penis | + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant Mixed| X |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | |
Mesenteric, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + M + + + + + + + + M + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M M + + + M M + + M + M M M + + + + + + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Fibrosarcoma, | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|
| 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Metastatic, Skin | |
Subcutaneous Tissue, Sarcoma | |
Subcutaneous Tissue, Sarcoma, | |
Multiple | |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Fibrosarcoma, Multiple, Metastatic, | |
Skin | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Mediastinum, Fibrosarcoma, | |
Metastatic, Skin | |
Pleura, Fibrosarcoma, Multiple, | |
Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X|
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urethra | + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|
| 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6| | |
| 6| 3| 2| 5| 5| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
__________________________________________________________________________|____________|
Gallbladder | + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + | 45 |
Lymphoma Malignant Mixed | | 1 |
Lymphoid Tissue, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 50 |
Lymphoma Malignant Mixed | | 1 |
Polyp Adenomatous | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Hepatocellular Carcinoma | | 9 |
Hepatocellular Adenoma | X | 8 |
Hepatocellular Adenoma, Multiple, Two| | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 54 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 18 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 54 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 54 |
Subcapsular, Adenoma | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6| | |
| 6| 3| 2| 5| 5| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 53 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 49 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 53 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Ductus Deferens | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + | 54 |
Hemangioma | | 1 |
__________________________________________________________________________|____________|
Penis | | 6 |
__________________________________________________________________________|____________|
Preputial Gland | | 12 |
__________________________________________________________________________|____________|
Prostate | + + + + | 54 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 54 |
__________________________________________________________________________|____________|
Testes | + + + + | 54 |
Interstitial Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 54 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Inguinal, Lymphoma Malignant Mixed | | 2 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mesenteric, Lymphoma Malignant Mixed | | 2 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 51 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + | 53 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6| | |
| 6| 3| 2| 5| 5| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 5 |
__________________________________________________________________________|____________|
Thymus | M + + + | 51 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 29 |
__________________________________________________________________________|____________|
Skin | + + + + | 54 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Metastatic, Skin | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
Subcutaneous Tissue, Sarcoma, | | |
Multiple | | 1 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Fibrosarcoma, Multiple, Metastatic, | | |
Skin | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Mediastinum, Fibrosarcoma, | | |
Metastatic, Skin | | 1 |
Pleura, Fibrosarcoma, Multiple, | | |
Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + | 54 |
Mucosa, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6| | |
| 6| 3| 2| 5| 5| 3| 3| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
Adenoma | | 2 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 54 |
Lymphoma Malignant Mixed | | 2 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urethra | + + | 18 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 54 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 54 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 0| 7| 6| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 4| 3| 6| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 2| 5| 3| 2| 2| 2| 2| 7| 7| 2| 2| 2| 2| 2| 1| 5| 5| 2| 2| 6| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | A + + M + + + + M |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + |
Lymphoid Tissue, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple, | |
Two | |
Hepatocellular Adenoma | X X X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + M |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 0| 7| 6| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 4| 3| 6| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 2| 5| 3| 2| 2| 2| 2| 7| 7| 2| 2| 2| 2| 2| 1| 5| 5| 2| 2| 6| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Mesenteric, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M M + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multifocal | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X|
Alveolar/Bronchiolar Adenoma, | |
Multiple, Two | X |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Multiple, | |
Metastatic, Four, Liver | X |
Hepatocellular Carcinoma, Multiple, | |
Metastatic, Greater Than Five, | |
Liver | |
Mediastinum, Hepatocellular | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 0| 7| 6| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 4| 3| 6| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 2| 5| 3| 2| 2| 2| 2| 7| 7| 2| 2| 2| 2| 2| 1| 5| 5| 2| 2| 6| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Carcinoma, Metastatic, Liver | X |
__________________________________________________________________________|
Nose | + A + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 3| 7| 7| 3| 7| 7| 1| 7| 7| 6| 6| 7| 3| 3| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 1| 8| 8| 3| 3| 8| 3| 3| 2| 3| 3| 5| 9| 3| 8| 8| 3| 3| 3| 3| 3| 1| 3|
| 1| 0| 3| 4| 3| 1| 1| 4| 1| 1| 1| 5| 5| 4| 7| 5| 4| 4| 5| 5| 5| 5| 5| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + M A + M + + + + M |
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + + + + A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + A A + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + A A + + + + A + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A A + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + M A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A A + + + + A + + |
Lymphoid Tissue, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X X X|
Hepatocellular Carcinoma, Multiple, | |
Two | X X |
Hepatocellular Adenoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + A A + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + M A + + + + + + |
__________________________________________________________________________|
Stomach | + + + A + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + M + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + M + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + A A + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + M M + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 3| 7| 7| 3| 7| 7| 1| 7| 7| 6| 6| 7| 3| 3| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 1| 8| 8| 3| 3| 8| 3| 3| 2| 3| 3| 5| 9| 3| 8| 8| 3| 3| 3| 3| 3| 1| 3|
| 1| 0| 3| 4| 3| 1| 1| 4| 1| 1| 1| 5| 5| 4| 7| 5| 4| 4| 5| 5| 5| 5| 5| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + |
__________________________________________________________________________|
Penis | + + + |
__________________________________________________________________________|
Preputial Gland | + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + M + + M + + + + + + + +|
Mesenteric, Lymphoma Malignant Mixed | X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M M + + + M M + |
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Mixed | X X|
__________________________________________________________________________|
Thymus | M + + M M + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M + + M + M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Fibrosarcoma, | |
Multifocal | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple, Two | |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Multiple, | |
Metastatic, Four, Liver | |
Hepatocellular Carcinoma, Multiple, | |
Metastatic, Greater Than Five, | |
Liver | X |
Mediastinum, Hepatocellular | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 3| 7| 7| 3| 7| 7| 1| 7| 7| 6| 6| 7| 3| 3| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 1| 8| 8| 3| 3| 8| 3| 3| 2| 3| 3| 5| 9| 3| 8| 8| 3| 3| 3| 3| 3| 1| 3|
| 1| 0| 3| 4| 3| 1| 1| 4| 1| 1| 1| 5| 5| 4| 7| 5| 4| 4| 5| 5| 5| 5| 5| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Carcinoma, Metastatic, Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X X X|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 5| 7| 0| 4| 4| 7| 4| | |
DAY ON TEST | 6| 6| 6| 9| 3| 9| 6| 6| 3| 6| | |
| 3| 3| 3| 8| 5| 3| 3| 3| 5| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 22 |
__________________________________________________________________________|____________|
Gallbladder | + + | 16 |
__________________________________________________________________________|____________|
Intestine Large | + + | 21 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 21 |
__________________________________________________________________________|____________|
Intestine Small | + M | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M | 17 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M | 19 |
Lymphoid Tissue, Lymphoma Malignant | | |
Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + | 53 |
Hepatocellular Carcinoma | | 10 |
Hepatocellular Carcinoma, Multiple, | | |
Two | | 2 |
Hepatocellular Adenoma | | 5 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 21 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + | 21 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 21 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 21 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 22 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 22 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 21 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M | 22 |
__________________________________________________________________________|____________|
Pituitary Gland | + M | 17 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 54 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 5| 7| 0| 4| 4| 7| 4| | |
DAY ON TEST | 6| 6| 6| 9| 3| 9| 6| 6| 3| 6| | |
| 3| 3| 3| 8| 5| 3| 3| 3| 5| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + | 22 |
__________________________________________________________________________|____________|
Penis | | 4 |
__________________________________________________________________________|____________|
Preputial Gland | | 7 |
__________________________________________________________________________|____________|
Prostate | + + | 22 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 23 |
__________________________________________________________________________|____________|
Testes | + + | 22 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 22 |
__________________________________________________________________________|____________|
Lymph Node | + + | 27 |
Mesenteric, Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 17 |
__________________________________________________________________________|____________|
Spleen | + + + + | 53 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Thymus | + + | 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M | 11 |
__________________________________________________________________________|____________|
Skin | + + + + | 43 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 5 |
Subcutaneous Tissue, Fibrosarcoma, | | |
Multifocal | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 22 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 22 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + | 32 |
Alveolar/Bronchiolar Adenoma | X | 7 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple, Two | | 1 |
Alveolar/Bronchiolar Carcinoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 5| 7| 0| 4| 4| 7| 4| | |
DAY ON TEST | 6| 6| 6| 9| 3| 9| 6| 6| 3| 6| | |
| 3| 3| 3| 8| 5| 3| 3| 3| 5| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hepatocellular Carcinoma, Multiple, | | |
Metastatic, Four, Liver | | 1 |
Hepatocellular Carcinoma, Multiple, | | |
Metastatic, Greater Than Five, | | |
Liver | | 1 |
Mediastinum, Hepatocellular | | |
Carcinoma, Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Nose | + + | 21 |
__________________________________________________________________________|____________|
Trachea | + + | 22 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 53 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Urethra | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 53 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 54 |
Lymphoma Malignant Mixed | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 7| 6| 6| 7| 7| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 4| 7| 5| 3| 0| 3| 2| 5| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 3| 3|
| 1| 1| 1| 1| 4| 1| 8| 4| 1| 1| 2| 7| 4| 2| 2| 8| 2| 5| 2| 2| 9| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + A + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + A A + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + |
Polyp Adenomatous | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A A + |
Lymphoid Tissue, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hepatocellular Carcinoma | X X X X X X|
Hepatocellular Carcinoma, Multiple, | |
Two | |
Hepatocellular Carcinoma, Multiple, | |
Four | X |
Hepatocellular Adenoma | X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + A + + |
__________________________________________________________________________|
Stomach | + + + + + + + A + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + |
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + A + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + A + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + A + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + A + + |
Lymphoma Malignant Mixed | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + A + + |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 7| 6| 6| 7| 7| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 4| 7| 5| 3| 0| 3| 2| 5| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 3| 3|
| 1| 1| 1| 1| 4| 1| 8| 4| 1| 1| 2| 7| 4| 2| 2| 8| 2| 5| 2| 2| 9| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + A + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + A + + |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + A M + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + A + + |
__________________________________________________________________________|
Testes | + + + + + + + A + + + |
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + A + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + A + + + + |
Mesenteric, Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M M + A + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + + + A + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + M M M + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + A + + + + + + +|
Basosquamous Tumor Benign | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X X X X|
Subcutaneous Tissue, Sarcoma | |
Subcutaneous Tissue, Schwannoma NOS | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + A + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + A + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + A + + |
Alveolar/Bronchiolar Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 7| 6| 6| 7| 7| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 4| 7| 5| 3| 0| 3| 2| 5| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 3| 3|
| 1| 1| 1| 1| 4| 1| 8| 4| 1| 1| 2| 7| 4| 2| 2| 8| 2| 5| 2| 2| 9| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple, Two | X |
Hepatocellular Carcinoma, Multiple, | |
Metastatic, Five, Liver | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + A + + |
__________________________________________________________________________|
Trachea | + + + + + + + A + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 9| 9| 2| 6| 0| 3| 3| 3| 3| 9| 3| 9| 3| 1| 8| 3| 3| 3|
| 9| 5| 5| 5| 5| 5| 5| 7| 7| 4| 7| 1| 5| 5| 5| 5| 3| 5| 9| 5| 4| 2| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + |
Polyp Adenomatous | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + |
Lymphoid Tissue, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X X X X X X |
Hepatocellular Carcinoma, Multiple, | |
Two | X |
Hepatocellular Carcinoma, Multiple, | |
Four | |
Hepatocellular Adenoma | X X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + |
Lymphoma Malignant Mixed | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 9| 9| 2| 6| 0| 3| 3| 3| 3| 9| 3| 9| 3| 1| 8| 3| 3| 3|
| 9| 5| 5| 5| 5| 5| 5| 7| 7| 4| 7| 1| 5| 5| 5| 5| 3| 5| 9| 5| 4| 2| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + |
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Mesenteric, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M M + M M + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + M + + + + + + + + +|
Basosquamous Tumor Benign | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X X X X |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Schwannoma NOS | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 9| 9| 2| 6| 0| 3| 3| 3| 3| 9| 3| 9| 3| 1| 8| 3| 3| 3|
| 9| 5| 5| 5| 5| 5| 5| 7| 7| 4| 7| 1| 5| 5| 5| 5| 3| 5| 9| 5| 4| 2| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple, Two | |
Hepatocellular Carcinoma, Multiple, | |
Metastatic, Five, Liver | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 3| 3| 4| 4| 4| | |
DAY ON TEST | 3| 6| 6| 6| 3| 4| 9| 6| 6| 6| | |
| 5| 3| 3| 3| 5| 6| 4| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 21 |
__________________________________________________________________________|____________|
Gallbladder | A + | 19 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large | A + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + | 19 |
__________________________________________________________________________|____________|
Intestine Small | A + | 21 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + | 20 |
Polyp Adenomatous | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A M | 17 |
Lymphoid Tissue, Lymphoma Malignant | | |
Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + | 18 |
__________________________________________________________________________|____________|
Liver | + + + + | 53 |
Hepatocellular Carcinoma | | 15 |
Hepatocellular Carcinoma, Multiple, | | |
Two | | 1 |
Hepatocellular Carcinoma, Multiple, | | |
Four | | 1 |
Hepatocellular Adenoma | | 6 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + | 23 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 21 |
__________________________________________________________________________|____________|
Stomach | + + | 21 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 20 |
__________________________________________________________________________|____________|
Tooth | | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 21 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 22 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 20 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 89
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 3| 3| 4| 4| 4| | |
DAY ON TEST | 3| 6| 6| 6| 3| 4| 9| 6| 6| 6| | |
| 5| 3| 3| 3| 5| 6| 4| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 21 |
Lymphoma Malignant Mixed | | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 21 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 21 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 53 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 21 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 6 |
__________________________________________________________________________|____________|
Prostate | + + | 20 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 23 |
__________________________________________________________________________|____________|
Testes | + + | 22 |
Interstitial Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + | 21 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 33 |
Mesenteric, Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 19 |
__________________________________________________________________________|____________|
Spleen | + + + + | 53 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Thymus | M + | 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | 9 |
__________________________________________________________________________|____________|
Skin | + + + | 45 |
Basosquamous Tumor Benign | | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Fibrosarcoma | | 8 |
Subcutaneous Tissue, Sarcoma | | 1 |
Subcutaneous Tissue, Schwannoma NOS | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 90
NTP Experiment-Test: 05025-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/09/97
Route: DOSED FEED Time: 07:33:23
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 3| 3| 4| 4| 4| | |
DAY ON TEST | 3| 6| 6| 6| 3| 4| 9| 6| 6| 6| | |
| 5| 3| 3| 3| 5| 6| 4| 3| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 21 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 21 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 25 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple, Two | | 1 |
Hepatocellular Carcinoma, Multiple, | | |
Metastatic, Five, Liver | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + | 21 |
__________________________________________________________________________|____________|
Trachea | + + | 21 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 53 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Urethra | + | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 53 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
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---------- END OF REPORT ----------
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