TDMS Study 05025-01 Pathology Tables
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
Facility: Southern Research Institute
Chemical CAS #: 107-21-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 5| 6| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 9| 3| 6| 3| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 7| 9| 3| 3| 0| 3|
| 1| 1| 1| 1| 5| 7| 1| 5| 6| 6| 8| 6| 6| 6| 6| 2| 6| 6| 6| 4| 6| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + M + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + M + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + M + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + M + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2|
Hyperplasia, Lymphoid | 1 1 1 1 1 1 1 |
Infarct | |
Infiltration Cellular, Mixed Cell | 2 2|
Inflammation, Multifocal | 1 1 1 1 1 1 1 1 1 1 |
Necrosis, Multifocal | 3 1 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Hemorrhage | 2 |
Inflammation, Suppurative | 4 3 4 4|
Fat, Necrosis | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + M + + + + + + + + +|
Duct, Dilatation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
Inflammation, Focal | 1 |
Mineralization | 1 |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Artery, Media, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 5| 6| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 9| 3| 6| 3| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 7| 9| 3| 3| 0| 3|
| 1| 1| 1| 1| 5| 7| 1| 5| 6| 6| 8| 6| 6| 6| 6| 2| 6| 6| 6| 4| 6| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hemorrhage, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Bacterium | |
Pars Distalis, Cyst | 2 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 1 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Degeneration, Cystic | 2 |
Inflammation, Focal | 1 1|
Follicular Cell, Hyperplasia | 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Inflammation, Suppurative | 4 3 4 4 4 4|
Follicle, Cyst | 3 2 3 1 3 3 |
__________________________________________________________________________|
Oviduct | + +|
Inflammation, Suppurative | 3 4|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 3 |
Inflammation, Suppurative | 2 2 2 4|
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 2 1 3 2 3 3 2 2 2 3 3 2 1 2 1 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 3 3 |
Mediastinal, Inflammation, | |
Suppurative | 3 3 3 |
Mesenteric, Angiectasis | 1 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 1 |
Mesenteric, Hyperplasia | 2 |
Mesenteric, Inflammation, Suppurative| 3 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 5| 6| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 9| 3| 6| 3| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 7| 9| 3| 3| 0| 3|
| 1| 1| 1| 1| 5| 7| 1| 5| 6| 6| 8| 6| 6| 6| 6| 2| 6| 6| 6| 4| 6| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hyperplasia | 4 |
Renal, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + M + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Depletion Cellular | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 3 3 3 2 3 3 2|
Hyperplasia, Lymphoid | 3 2 2 2 2 3 1 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Dilatation | 2 2 |
Hyperplasia | 2 |
Inflammation, Suppurative | |
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Distal, Joint, Femur, Arthrosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 1 2 1 1 1 1 1 2 1 1 1 1|
Infiltration Cellular, Mixed Cell | 2 3 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | |
Artery, Media, Hyperplasia | 1 1 |
Mediastinum, Inflammation, | |
Suppurative | 3 |
Vein, Intima, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 5| 7| 5| 6| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 6| 9| 3| 6| 3| 3| 9| 3| 3| 3| 3| 7| 3| 4| 3| 7| 9| 3| 3| 0| 3|
| 1| 1| 1| 1| 5| 7| 1| 5| 6| 6| 8| 6| 6| 6| 6| 2| 6| 6| 6| 4| 6| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 1 1 |
Lumen, Foreign Body | 1 |
Mucosa, Angiectasis | 2 |
Mucosa, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +|
Bacterium | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic | 2|
Metaplasia, Osseous | |
Nephropathy | 2 2 1 1 1 1 1 1 4 4 1 1|
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3|
| 6| 6| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 8| 7| 7| 7| 7| 1| 7| 7| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 1 1 1 1 1 1 1 |
Infarct | 4 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Multifocal | 1 1 1 1 1 1 1|
Necrosis, Multifocal | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Hemorrhage | |
Inflammation, Suppurative | 2 3 |
Fat, Necrosis | 2 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Focal | |
Mineralization | |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Artery, Media, Hyperplasia | 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3|
| 6| 6| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 8| 7| 7| 7| 7| 1| 7| 7| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hemorrhage, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Bacterium | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 |
Inflammation, Focal | 1 |
Follicular Cell, Hyperplasia | 1 2 1 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + M + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Suppurative | 4 4 |
Follicle, Cyst | 2 3 2 1 3 |
__________________________________________________________________________|
Oviduct | + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Inflammation, Suppurative | 3 4 |
Endometrium, Cyst | 4 |
Endometrium, Hyperplasia, Cystic | 3 3 3 2 3 2 3 3 3 3 2 4 3 3 3 3 3 3 3 3 4 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia | 3 |
Mediastinal, Inflammation, | |
Suppurative | 3 4 |
Mesenteric, Angiectasis | 1 2 1 |
Mesenteric, Hyperplasia, Lymphoid | 2 |
Mesenteric, Hyperplasia | 4 |
Mesenteric, Inflammation, Suppurative| 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3|
| 6| 6| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 8| 7| 7| 7| 7| 1| 7| 7| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hyperplasia | 4 |
Renal, Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + M + + + + + + + M M + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 1 |
Fibrosis, Focal | 3|
Hematopoietic Cell Proliferation | 2 3 2 4 2 3 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Thymus | + + + M M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 |
Hyperplasia | 2 |
Inflammation, Suppurative | 2 |
Duct, Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Distal, Joint, Femur, Arthrosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + M + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage, Multifocal | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 3 |
Hemorrhage | 4 1 |
Hyperplasia, Lymphoid | 1 2 1 1 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Suppurative | 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Media, Hyperplasia | 2 |
Mediastinum, Inflammation, | |
Suppurative | |
Vein, Intima, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 9| 3| 3| 1| 3| 3| 3| 3| 8| 3| 3| 7| 3| 3|
| 6| 6| 6| 6| 6| 6| 5| 0| 6| 6| 6| 6| 6| 6| 8| 7| 7| 7| 7| 1| 7| 7| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
UNTREATD | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | |
Lumen, Foreign Body | |
Mucosa, Angiectasis | |
Mucosa, Hemorrhage | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic | |
Metaplasia, Osseous | 1 |
Nephropathy | 2 1 1 1 2 1 1 1 2 2 1 2 1|
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 48 |
__________________________________________________________________________|____________|
Intestine Large | | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 49 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 49 |
__________________________________________________________________________|____________|
Intestine Small | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 47 |
__________________________________________________________________________|____________|
Liver | | 50 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Lymphoid | | 14 1.0|
Infarct | | 1 4.0|
Infiltration Cellular, Mixed Cell | | 4 2.0|
Inflammation, Multifocal | | 17 1.0|
Necrosis, Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 17 |
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | | 6 3.3|
Fat, Necrosis | | 8 2.4|
__________________________________________________________________________|____________|
Pancreas | | 49 |
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | | 49 |
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 49 |
Hyperplasia, Lymphoid | | 2 1.5|
Inflammation, Focal | | 1 1.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Incisor, Dysplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 50 |
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Artery, Media, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 49 |
Hemorrhage, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 48 |
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 49 |
Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Bacterium | | 1 2.0|
Pars Distalis, Cyst | | 2 1.5|
Pars Distalis, Hyperplasia, Focal | | 13 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | | 49 |
Degeneration, Cystic | | 4 1.3|
Inflammation, Focal | | 3 1.0|
Follicular Cell, Hyperplasia | | 8 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 49 |
Angiectasis | | 1 2.0|
Inflammation, Suppurative | | 8 3.9|
Follicle, Cyst | | 11 2.4|
__________________________________________________________________________|____________|
Oviduct | | 3 |
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Uterus | | 50 |
Hydrometra | | 3 2.7|
Inflammation, Suppurative | | 6 2.8|
Endometrium, Cyst | | 1 4.0|
Endometrium, Hyperplasia, Cystic | | 44 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia | | 3 3.0|
Mediastinal, Inflammation, | | |
Suppurative | | 5 3.2|
Mesenteric, Angiectasis | | 4 1.3|
Mesenteric, Hyperplasia, Lymphoid | | 5 1.8|
Mesenteric, Hyperplasia | | 2 3.0|
Mesenteric, Inflammation, Suppurative| | 2 2.5|
Renal, Hyperplasia | | 2 4.0|
Renal, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 43 |
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 49 |
Depletion Cellular | | 1 1.0|
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | | 14 2.6|
Hyperplasia, Lymphoid | | 11 2.4|
__________________________________________________________________________|____________|
Thymus | | 47 |
Hyperplasia, Lymphoid | | 7 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 49 |
Dilatation | | 4 1.8|
Hyperplasia | | 2 2.0|
Inflammation, Suppurative | | 1 2.0|
Duct, Metaplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Skin | | 49 |
Inflammation, Chronic | | 16 1.1|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Distal, Joint, Femur, Arthrosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
UNTREATD | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Compression | | 1 3.0|
Hemorrhage, Multifocal | | 2 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Bacterium | | 1 3.0|
Hemorrhage | | 2 2.5|
Hyperplasia, Lymphoid | | 17 1.2|
Infiltration Cellular, Mixed Cell | | 3 2.3|
Inflammation, Suppurative | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Artery, Media, Hyperplasia | | 3 1.3|
Mediastinum, Inflammation, | | |
Suppurative | | 1 3.0|
Vein, Intima, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Nose | | 50 |
Lumen, Exudate | | 2 1.0|
Lumen, Foreign Body | | 1 1.0|
Mucosa, Angiectasis | | 1 2.0|
Mucosa, Hemorrhage | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 49 |
Bacterium | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | | 25 1.5|
Renal Tubule, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 49 |
Hyperplasia, Lymphoid | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|
| 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 3 |
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 |
Lymphoid Tissue, Inflammation, | |
Granulomatous | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Congestion | 2 |
Fatty Change | 1 1 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 2 1 1 2 1|
Infarct | |
Infiltration Cellular, Mixed Cell | 2 1 |
Inflammation, Multifocal | 1 2 1 1 1 1 1 1 2 1 |
Necrosis, Multifocal | 1 2 |
Pigmentation | |
Hepatocyte, Erythrophagocytosis | 2 2 |
Hepatocyte, Centrilobular, | |
Degeneration, Hyaline | 2 2 2 1 2 1 1 1 1 1 1 |
Portal Vein, Media, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Edema | 2 |
Inflammation, Suppurative | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 4 |
Ectopic Tissue | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|
| 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinar Cell, Hypoplasia, Focal | |
Duct, Dilatation | 3 |
Duct, Dilatation, Multiple | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | |
Mineralization | |
Mucosa, Hyperplasia, Papillary | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Focal | 1 |
Mineralization | |
Epithelium, Degeneration, Hyaline | 2 |
Epithelium, Metaplasia, Squamous | 1 |
Mucosa, Cyst | |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Amyloid Deposition | 1 |
Angiectasis | |
Hyperplasia, Focal | 3|
Inflammation, Suppurative | 2 |
Vacuolization Cytoplasmic, Focal | 2 1 |
Subcapsular, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | 1 |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + M + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 1 1 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|
| 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
Inflammation, Focal | 1 |
C-Cell, Hyperplasia | 2 |
Follicular Cell, Hyperplasia | 1 4 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Atrophy | |
Fibrosis, Focal | |
Hemorrhage | 3 |
Inflammation, Suppurative | |
Mineralization | 3 |
Follicle, Cyst | 2 2 1 3 |
__________________________________________________________________________|
Oviduct | + |
Hyperplasia, Cystic | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | 2 |
Hydrometra | 3 2 3 |
Inflammation, Suppurative | |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 2 3 3 2 2 1 2 3 3 3 3 4 2 3 2 3 3 2 3 3 2 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | |
Inguinal, Hyperplasia | |
Mediastinal, Hyperplasia, Lymphoid | 2 1 |
Mediastinal, Hyperplasia | |
Mesenteric, Angiectasis | 1 1 1|
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 1 2|
Mesenteric, Hyperplasia | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 2 2 2|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 4 3 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|
| 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 3 2 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia, Lymphoid | 3 2 2 2 2|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 3 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 |
Subcutaneous Tissue, Edema | 3 |
Subcutaneous Tissue, Hyperplasia, | |
Lymphoid | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 2 |
Meninges, Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 3 1 2 2 2 2 2|
Hyperplasia, Macrophage | 1 |
Infiltration Cellular, Mixed Cell | 1 |
Mineralization | |
Pigmentation | 1 |
Artery, Inflammation | 2 |
Artery, Media, Hyperplasia | 1 2 2 2 2 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 1 |
Lumen, Foreign Body | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 3| 4| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 9| 6| 8| 3| 5| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 3| 3|
| 6| 6| 6| 9| 6| 1| 9| 2| 6| 9| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 8| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retinal Detachment | 3 |
Cornea, Inflammation | 1 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Mixed Cell | |
Nephropathy | 1 1 1 1 1 1 2 1 1 1 2 1 1 |
Pelvis, Dilatation | 2 |
Renal Tubule, Degeneration, Hyaline | 3 |
Renal Tubule, Dilatation | 1 |
Renal Tubule, Pigmentation | 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Inflammation, Chronic | 3 |
Ulcer | 2 |
Transitional Epithelium, Metaplasia, | |
Squamous | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2|
Lymphoid Tissue, Inflammation, | |
Granulomatous | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Congestion | |
Fatty Change | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 1 1 1 2 1 1 |
Infarct | 4 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Multifocal | 2 1 1 1 1 1 2 2 2 1 1 1 2 1|
Necrosis, Multifocal | |
Pigmentation | 2 |
Hepatocyte, Erythrophagocytosis | |
Hepatocyte, Centrilobular, | |
Degeneration, Hyaline | 2 1 2 2 1 1 1 2 2 1 1 1 1 1 1|
Portal Vein, Media, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + |
Edema | |
Inflammation, Suppurative | 4 4 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 4 |
Ectopic Tissue | 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinar Cell, Hypoplasia, Focal | 3 |
Duct, Dilatation | 2 4 |
Duct, Dilatation, Multiple | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 1 1 |
Mineralization | 1 |
Mucosa, Hyperplasia, Papillary | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
Inflammation, Focal | 2 2 1 |
Mineralization | 1 1 2 |
Epithelium, Degeneration, Hyaline | 2|
Epithelium, Metaplasia, Squamous | |
Mucosa, Cyst | 2 2 |
__________________________________________________________________________|
Tooth | + + |
Incisor, Dysplasia | 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mesenteric Artery, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Amyloid Deposition | |
Angiectasis | 3 |
Hyperplasia, Focal | |
Inflammation, Suppurative | |
Vacuolization Cytoplasmic, Focal | |
Subcapsular, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | 1 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + M + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 1 1 1 1 1 2 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 |
Inflammation, Focal | 2 1 |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 2 1 3 2 1 1 3 1 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | M + + + + + + + + + + + + M + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | 3 3 |
Fibrosis, Focal | 3 |
Hemorrhage | 2 |
Inflammation, Suppurative | 4 4 4 |
Mineralization | 3 |
Follicle, Cyst | 3 3 3 2 4 |
__________________________________________________________________________|
Oviduct | |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hemorrhage | 3 |
Hydrometra | 3 |
Inflammation, Suppurative | 2 2 2 |
Endometrium, Cyst | 3 3 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 2 2 3 3 2 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | 3 |
Inguinal, Hyperplasia | 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 2 |
Mesenteric, Angiectasis | 1 2 1 |
Mesenteric, Hyperplasia, Lymphoid | 2 |
Mesenteric, Hyperplasia | 2 2 |
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 3 3 4 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + M + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 1 |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 1 1 1 1 1|
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Hyperplasia, | |
Lymphoid | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Meninges, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 1 1 2 2 2 1 2 2 |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | |
Mineralization | 1 |
Pigmentation | |
Artery, Inflammation | |
Artery, Media, Hyperplasia | 2 1 1 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | |
Lumen, Foreign Body | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 6| 6| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 1| 7| 5| 5| 7| 7| 7| 5| 4| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retinal Detachment | |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Nephropathy | 1 2 3 1 1 2 1 1 1 1 1 1 1 3 2 |
Pelvis, Dilatation | |
Renal Tubule, Degeneration, Hyaline | 2 |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 1 2 |
Inflammation, Chronic | |
Ulcer | |
Transitional Epithelium, Metaplasia, | |
Squamous | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 50 |
__________________________________________________________________________|____________|
Gallbladder | | 49 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 50 |
Edema | | 1 2.0|
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 50 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 50 |
Amyloid Deposition | | 2 2.0|
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 2 2.0|
Lymphoid Tissue, Inflammation, | | |
Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 50 |
Amyloid Deposition | | 1 1.0|
__________________________________________________________________________|____________|
Liver | | 50 |
Basophilic Focus | | 1 2.0|
Congestion | | 1 2.0|
Fatty Change | | 3 1.3|
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Lymphoid | | 12 1.3|
Infarct | | 1 4.0|
Infiltration Cellular, Mixed Cell | | 4 1.8|
Inflammation, Multifocal | | 24 1.3|
Necrosis, Multifocal | | 2 1.5|
Pigmentation | | 1 2.0|
Hepatocyte, Erythrophagocytosis | | 2 2.0|
Hepatocyte, Centrilobular, | | |
Degeneration, Hyaline | | 26 1.3|
Portal Vein, Media, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Edema | | 1 2.0|
Inflammation, Suppurative | | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | | 50 |
Atrophy, Focal | | 3 3.3|
Ectopic Tissue | | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
Acinar Cell, Hypoplasia, Focal | | 1 3.0|
Duct, Dilatation | | 3 3.0|
Duct, Dilatation, Multiple | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | | 50 |
__________________________________________________________________________|____________|
Stomach | | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 50 |
Inflammation, Focal | | 2 1.0|
Mineralization | | 1 1.0|
Mucosa, Hyperplasia, Papillary | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 50 |
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Focal | | 4 1.5|
Mineralization | | 3 1.3|
Epithelium, Degeneration, Hyaline | | 2 2.0|
Epithelium, Metaplasia, Squamous | | 1 1.0|
Mucosa, Cyst | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 3 |
Incisor, Dysplasia | | 3 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Heart | | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 50 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Amyloid Deposition | | 1 1.0|
Angiectasis | | 1 3.0|
Hyperplasia, Focal | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Subcapsular, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 50 |
Ectopic Tissue | | 2 1.0|
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | | 47 |
Pars Distalis, Hyperplasia, Focal | | 14 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Degeneration, Cystic | | 4 1.3|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Focal | | 3 1.3|
C-Cell, Hyperplasia | | 1 2.0|
Follicular Cell, Hyperplasia | | 14 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 48 |
Angiectasis | | 3 2.3|
Atrophy | | 2 3.0|
Fibrosis, Focal | | 1 3.0|
Hemorrhage | | 2 2.5|
Inflammation, Suppurative | | 3 4.0|
Mineralization | | 2 3.0|
Follicle, Cyst | | 9 2.6|
__________________________________________________________________________|____________|
Oviduct | | 1 |
Hyperplasia, Cystic | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | | 50 |
Angiectasis | | 2 2.5|
Hemorrhage | | 2 2.5|
Hydrometra | | 4 2.8|
Inflammation, Suppurative | | 3 2.0|
Endometrium, Cyst | | 2 3.0|
Endometrium, Hyperplasia, Cystic | | 47 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Neutrophil | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 50 |
Iliac, Hyperplasia | | 1 3.0|
Inguinal, Hyperplasia | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 1.5|
Mediastinal, Hyperplasia | | 1 2.0|
Mesenteric, Angiectasis | | 6 1.2|
Mesenteric, Hyperplasia, Lymphoid | | 7 1.9|
Mesenteric, Hyperplasia | | 2 2.0|
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 49 |
Hyperplasia, Lymphoid | | 6 2.3|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | | 50 |
Hematopoietic Cell Proliferation | | 13 3.1|
Hyperplasia, Lymphoid | | 13 2.2|
__________________________________________________________________________|____________|
Thymus | | 47 |
Cyst | | 1 2.0|
Hyperplasia, Lymphoid | | 6 2.0|
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 50 |
Dilatation | | 6 2.2|
__________________________________________________________________________|____________|
Skin | | 50 |
Inflammation, Chronic | | 11 1.2|
Subcutaneous Tissue, Edema | | 1 3.0|
Subcutaneous Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 50 |
Cranium, Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Compression | | 3 2.7|
Meninges, Hyperplasia, Lymphoid | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Hyperplasia, Lymphoid | | 21 1.8|
Hyperplasia, Macrophage | | 1 1.0|
Infiltration Cellular, Mixed Cell | | 1 1.0|
Mineralization | | 1 1.0|
Pigmentation | | 1 1.0|
Artery, Inflammation | | 1 2.0|
Artery, Media, Hyperplasia | | 23 1.5|
__________________________________________________________________________|____________|
Nose | | 50 |
Lumen, Exudate | | 1 1.0|
Lumen, Foreign Body | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 2.0|
Retinal Detachment | | 1 3.0|
Cornea, Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Cyst | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Nephropathy | | 28 1.3|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Degeneration, Hyaline | | 2 2.5|
Renal Tubule, Dilatation | | 1 1.0|
Renal Tubule, Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | | 50 |
Hyperplasia, Lymphoid | | 5 1.8|
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 2.0|
Transitional Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 1| 6| 6| 6| 1| 6| 6| 6| 4| 6| 6| 6| 6| 7| 8| 9| 0| 6| 6| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
Dilatation | |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
Dilatation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change | 2 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 2 1 1 1 1 1 2|
Infarct | |
Infiltration Cellular, Mixed Cell | 1 2 2|
Inflammation, Multifocal | 1 1 1 1 1 1 1 1 1 1 1|
Mineralization | |
Necrosis, Multifocal | 2 |
Hepatocyte, Centrilobular, | |
Degeneration, Hyaline | 1 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Cyst | 2 |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + |
Inflammation, Suppurative | 3 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
Inflammation, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
__________________________________________________________________________|
Tooth | |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Infiltration Cellular, Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 1| 6| 6| 6| 1| 6| 6| 6| 4| 6| 6| 6| 6| 7| 8| 9| 0| 6| 6| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + M + M M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + |
Pars Distalis, Focal Cellular Change | 1 1 |
Pars Distalis, Hyperplasia, Focal | |
Pars Nervosa, Inflammation, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 |
Inflammation, Focal | 1 1 1 |
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 2 2 1 1 1 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abdominal, Infiltration Cellular, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + |
Granuloma | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 4 |
Follicle, Cyst | |
__________________________________________________________________________|
Oviduct | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
Hydrometra | |
Inflammation, Suppurative | 1 1 |
Endometrium, Hyperplasia, Cystic | 3 4 3 3 3 1 3 3 2 3 2 3 2 2 3 3 3 1 3 3 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Hyperplasia, Neutrophil | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Iliac, Hyperplasia | |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 1| 6| 6| 6| 1| 6| 6| 6| 4| 6| 6| 6| 6| 7| 8| 9| 0| 6| 6| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Inflammation, | |
Suppurative | |
Mesenteric, Hyperplasia, Lymphoid | 2 |
Mesenteric, Hyperplasia | |
Pancreatic, Hyperplasia | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 3|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
Dilatation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Compression | 4 |
Artery, Inflammation, Chronic | |
Meninges, Infiltration Cellular, | |
Mixed Cell | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 2 1 |
Hyperplasia, Lymphoid | 1 2 1 1 1 1 1 1 |
Hyperplasia, Macrophage | 2 3 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Granulomatous | 1 |
Inflammation, Suppurative | |
Artery, Media, Hyperplasia | 1 2 1 1 1 |
Bronchiole, Bronchiectasis | 1 |
Bronchiole, Epithelium, Hyperplasia | 1 |
Mediastinum, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 3| 8| 3| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 0| 3| 3| 3| 3| 3| 3|
| 6| 6| 1| 6| 6| 6| 1| 6| 6| 6| 4| 6| 6| 6| 6| 7| 8| 9| 0| 6| 6| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Suppurative | 3 |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
Fibrosis | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 3 1 2 1 1 1 2 2 1 1 1 1 1|
Renal Tubule, Dilatation | |
Renal Tubule, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 6| 7| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 7| 3| 0| 3| 1| 3| 3| 6| 0| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 6| 3| 4|
| 7| 9| 7| 0| 8| 1| 7| 7| 5| 8| 7| 7| 8| 5| 0| 7| 4| 8| 2| 0| 8| 8| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A A + + + A A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A A + + + A A + +|
__________________________________________________________________________|
Intestine Small | + + + + A A + + + A A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A A + + + A A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A A + + + A A + +|
Dilatation | 3 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A A + + + A A + +|
Dilatation | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change | |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 3 2 2 1 2 |
Hyperplasia, Lymphoid | 2 1 1 1 2 1 1 2 |
Infarct | 3 |
Infiltration Cellular, Mixed Cell | 1 2 2 3 2 2 3 1|
Inflammation, Multifocal | 2 1 1 1 2 1 1 |
Mineralization | 3 |
Necrosis, Multifocal | |
Hepatocyte, Centrilobular, | |
Degeneration, Hyaline | |
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Cyst | |
Inflammation, Suppurative | 3 4 4 3 3 4 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + +|
Inflammation, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 6| 7| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 7| 3| 0| 3| 1| 3| 3| 6| 0| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 6| 3| 4|
| 7| 9| 7| 0| 8| 1| 7| 7| 5| 8| 7| 7| 8| 5| 0| 7| 4| 8| 2| 0| 8| 8| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + +|
Pars Distalis, Focal Cellular Change | |
Pars Distalis, Hyperplasia, Focal | 1 2 |
Pars Nervosa, Inflammation, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 2 |
Inflammation, Focal | |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 1 2 2 1 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Infiltration Cellular, | |
Lymphocyte | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + +|
Granuloma | 3 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 4 4 4 4 4 4 4|
Follicle, Cyst | 3 1 3 3 3 2 4 3 |
__________________________________________________________________________|
Oviduct | + + + +|
Inflammation, Suppurative | 3 3 4 3|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hemorrhage | 4 |
Hydrometra | 3 2 |
Inflammation, Suppurative | 2 2 2|
Endometrium, Hyperplasia, Cystic | 3 3 3 2 4 3 3 3 3 3 2 3 3 3 3 2 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Iliac, Hyperplasia | 3 3 3 3 |
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia | 3 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 6| 7| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 7| 3| 0| 3| 1| 3| 3| 6| 0| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 6| 3| 4|
| 7| 9| 7| 0| 8| 1| 7| 7| 5| 8| 7| 7| 8| 5| 0| 7| 4| 8| 2| 0| 8| 8| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Inflammation, | |
Suppurative | 3 |
Mesenteric, Hyperplasia, Lymphoid | 2 |
Mesenteric, Hyperplasia | 3 3 |
Pancreatic, Hyperplasia | 4 |
Renal, Hyperplasia | 4 3 3 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + M + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 3 4 2 3 3 2 3|
Hyperplasia, Lymphoid | 3 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + M M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + +|
Compression | |
Artery, Inflammation, Chronic | 2 |
Meninges, Infiltration Cellular, | |
Mixed Cell | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 2 1 2 1 2 |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | 3 2 4 |
Inflammation, Granulomatous | 1 |
Inflammation, Suppurative | 3 |
Artery, Media, Hyperplasia | 1 1 2 1 1 |
Bronchiole, Bronchiectasis | |
Bronchiole, Epithelium, Hyperplasia | |
Mediastinum, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 5| 5| 4| 7| 6| 7| 6| 7| 7| 7| 6| 7| 5|
DAY ON TEST | 3| 7| 3| 0| 3| 1| 3| 3| 6| 0| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 3| 3| 6| 3| 4|
| 7| 9| 7| 0| 8| 1| 7| 7| 5| 8| 7| 7| 8| 5| 0| 7| 4| 8| 2| 0| 8| 8| 5| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Suppurative | 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
Fibrosis | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Metaplasia, Osseous | 1 1 |
Nephropathy | 3 1 2 1 1 1 1 1 2 2 1 2 2 1 2 3|
Renal Tubule, Dilatation | |
Renal Tubule, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 21 |
__________________________________________________________________________|____________|
Gallbladder | + | 21 |
__________________________________________________________________________|____________|
Intestine Large | + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M | 16 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 17 |
__________________________________________________________________________|____________|
Intestine Small | + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M | 16 |
Dilatation | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M | 16 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + | 51 |
Fatty Change | | 2 2.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | | 7 2.3|
Hyperplasia, Lymphoid | | 16 1.4|
Infarct | | 1 3.0|
Infiltration Cellular, Mixed Cell | | 11 1.9|
Inflammation, Multifocal | 1 | 19 1.1|
Mineralization | | 1 3.0|
Necrosis, Multifocal | | 1 2.0|
Hepatocyte, Centrilobular, | | |
Degeneration, Hyaline | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 15 |
Cyst | | 1 2.0|
Inflammation, Suppurative | | 9 3.2|
__________________________________________________________________________|____________|
Pancreas | + | 22 |
Inflammation, Suppurative | | 1 3.0|
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 21 |
__________________________________________________________________________|____________|
Stomach | + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 20 |
Inflammation, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 20 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Incisor, Dysplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + | 21 |
Infiltration Cellular, Mixed Cell | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 21 |
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 21 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 21 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | 14 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 23 |
Pars Distalis, Focal Cellular Change | | 2 1.0|
Pars Distalis, Hyperplasia, Focal | | 2 1.5|
Pars Nervosa, Inflammation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Degeneration, Cystic | | 4 1.3|
Inflammation, Focal | | 3 1.0|
C-Cell, Hyperplasia | | 1 1.0|
Follicular Cell, Hyperplasia | | 22 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Abdominal, Infiltration Cellular, | | |
Lymphocyte | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 25 |
Granuloma | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 9 4.0|
Follicle, Cyst | | 8 2.8|
__________________________________________________________________________|____________|
Oviduct | | 4 |
Inflammation, Suppurative | | 4 3.3|
__________________________________________________________________________|____________|
Uterus | + | 45 |
Angiectasis | | 1 3.0|
Hemorrhage | | 1 4.0|
Hydrometra | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 5 1.6|
Endometrium, Hyperplasia, Cystic | | 40 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 21 |
Hyperplasia, Neutrophil | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 22 |
Iliac, Hyperplasia | | 4 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia | | 3 2.7|
Mediastinal, Inflammation, | | |
Suppurative | | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid | | 2 2.0|
Mesenteric, Hyperplasia | | 2 3.0|
Pancreatic, Hyperplasia | | 1 4.0|
Renal, Hyperplasia | | 5 3.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 20 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + | 28 |
Hematopoietic Cell Proliferation | | 20 3.0|
Hyperplasia, Lymphoid | | 6 2.2|
__________________________________________________________________________|____________|
Thymus | + | 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 21 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + | 40 |
Inflammation, Chronic | | 6 1.2|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 21 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 21 |
Compression | | 1 4.0|
Artery, Inflammation, Chronic | | 1 2.0|
Meninges, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Mixed Cell | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Congestion | 2 | 2 2.0|
Hemorrhage | 3 | 4 1.8|
Hyperplasia, Lymphoid | | 15 1.4|
Hyperplasia, Macrophage | | 2 2.5|
Infiltration Cellular, Mixed Cell | | 3 3.0|
Inflammation, Granulomatous | | 2 1.0|
Inflammation, Suppurative | | 1 3.0|
Artery, Media, Hyperplasia | | 10 1.2|
Bronchiole, Bronchiectasis | | 1 1.0|
Bronchiole, Epithelium, Hyperplasia | | 1 1.0|
Mediastinum, Inflammation, | | |
Suppurative | | 3 3.0|
__________________________________________________________________________|____________|
Nose | + | 21 |
__________________________________________________________________________|____________|
Trachea | + | 21 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 50 |
Inflammation, Suppurative | | 2 2.5|
Metaplasia, Osseous | | 3 1.0|
Nephropathy | | 33 1.5|
Renal Tubule, Dilatation | 1 | 1 1.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 21 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 5| 5| 7| 4| 7| 5| 7| 7| 6| 5| 7| 7| 6|
DAY ON TEST | 8| 3| 3| 9| 3| 3| 6| 3| 3| 3| 3| 7| 4| 3| 3| 7| 3| 6| 1| 3| 4| 5| 3| 3| 9|
| 8| 6| 6| 6| 6| 6| 3| 6| 6| 9| 6| 9| 3| 5| 6| 2| 6| 1| 8| 6| 4| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 3 |
Congestion | 4 |
Cyst | 4 |
Hematopoietic Cell Proliferation | 3 3 3 |
Hyperplasia, Lymphoid | 2 2 1 1 1 |
Infarct | |
Infiltration Cellular, Mixed Cell | 1 2 2 4 3 |
Inflammation, Multifocal | 1 1 1 |
Necrosis, Multifocal | 1 |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Suppurative | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + +|
Atrophy, Diffuse | |
Atrophy, Focal | |
Inflammation, Suppurative | 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
Incisor, Dysplasia | 1 2 |
Incisor, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Thrombosis | 4 |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 5| 5| 7| 4| 7| 5| 7| 7| 6| 5| 7| 7| 6|
DAY ON TEST | 8| 3| 3| 9| 3| 3| 6| 3| 3| 3| 3| 7| 4| 3| 3| 7| 3| 6| 1| 3| 4| 5| 3| 3| 9|
| 8| 6| 6| 6| 6| 6| 3| 6| 6| 9| 6| 9| 3| 5| 6| 2| 6| 1| 8| 6| 4| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + +|
Focal Cellular Change | 2 |
Infiltration Cellular, Mixed Cell | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + +|
Pars Distalis, Focal Cellular Change | 2 |
Pars Distalis, Necrosis, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 2|
Follicular Cell, Hyperplasia | 1 3 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Foreign Body | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hemorrhage | 4 |
Inflammation, Suppurative | 4 4 4 4 4 |
Thrombosis | 4 |
Follicle, Cyst | 3 3 |
Follicle, Cyst, Multiple | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Hemorrhage | 4 |
Hydrometra | 3 3 4 |
Inflammation, Suppurative | 2 3 1 3 2 |
Thrombosis | 2 |
Endometrium, Hyperplasia, Cystic | 2 3 2 2 3 3 2 3 3 4 2 3 3 2 4 2 3 3 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Iliac, Hyperplasia | |
Mediastinal, Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 5| 5| 7| 4| 7| 5| 7| 7| 6| 5| 7| 7| 6|
DAY ON TEST | 8| 3| 3| 9| 3| 3| 6| 3| 3| 3| 3| 7| 4| 3| 3| 7| 3| 6| 1| 3| 4| 5| 3| 3| 9|
| 8| 6| 6| 6| 6| 6| 3| 6| 6| 9| 6| 9| 3| 5| 6| 2| 6| 1| 8| 6| 4| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 3 |
Mediastinal, Inflammation, | |
Suppurative | 3 |
Mesenteric, Angiectasis | 2 2 |
Mesenteric, Hyperplasia | |
Renal, Hyperplasia | |
Renal, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 3 3 2 3 3|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + A + + + + + + + +|
Cyst | 1 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + +|
Femur, Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + +|
Compression | 3 |
Gliosis | |
Infiltration Cellular, Lymphocyte | |
Necrosis, Focal | |
Artery, Meninges, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 1 1 3 2 2 2 |
Hyperplasia, Macrophage | 4 |
Infiltration Cellular, Mixed Cell | 3 |
Artery, Media, Hyperplasia | 2 1 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 5| 5| 7| 4| 7| 5| 7| 7| 6| 5| 7| 7| 6|
DAY ON TEST | 8| 3| 3| 9| 3| 3| 6| 3| 3| 3| 3| 7| 4| 3| 3| 7| 3| 6| 1| 3| 4| 5| 3| 3| 9|
| 8| 6| 6| 6| 6| 6| 3| 6| 6| 9| 6| 9| 3| 5| 6| 2| 6| 1| 8| 6| 4| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + +|
Artery, Peritracheal Tissue, | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1 |
Infiltration Cellular, Mixed Cell | 3 |
Inflammation, Suppurative | 3 2 |
Metaplasia, Osseous | 1 |
Necrosis, Multifocal | 2 |
Nephropathy | 2 1 2 1 1 1 |
Capsule, Inflammation, Suppurative | |
Renal Tubule, Degeneration, Hyaline | 1|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + +|
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 9| 1| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 6| 6| 7| 7| 4| 2| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + M + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
Amyloid Deposition | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | |
Congestion | |
Cyst | |
Hematopoietic Cell Proliferation | 2 4 3 |
Hyperplasia, Lymphoid | 2 1 2 1 1 2 1 1 1 |
Infarct | 3 |
Infiltration Cellular, Mixed Cell | 2 2 2 1 2 |
Inflammation, Multifocal | 2 1 1 1 1 2 1|
Necrosis, Multifocal | 2 |
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
Atrophy, Diffuse | 4 4 |
Atrophy, Focal | 2 |
Inflammation, Suppurative | |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
__________________________________________________________________________|
Tooth | + + |
Incisor, Dysplasia | 1 1 |
Incisor, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Thrombosis | |
Mesenteric Artery, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 9| 1| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 6| 6| 7| 7| 4| 2| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
Focal Cellular Change | |
Infiltration Cellular, Mixed Cell | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + |
Pars Distalis, Focal Cellular Change | 1 |
Pars Distalis, Necrosis, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 |
Follicular Cell, Hyperplasia | 1 2 1 1 1 2 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Foreign Body | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + |
Angiectasis | |
Hemorrhage | |
Inflammation, Suppurative | 4 4 4 4 3 |
Thrombosis | |
Follicle, Cyst | 3 3 2 |
Follicle, Cyst, Multiple | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 |
Hemorrhage | |
Hydrometra | 2 |
Inflammation, Suppurative | 3 2 |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 3 2 3 2 2 2 3 3 3 3 3 3 3 3 4 4 3 3 2 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Iliac, Hyperplasia | 3 |
Mediastinal, Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 9| 1| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 6| 6| 7| 7| 4| 2| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia, Lymphoid | 2 3 |
Mediastinal, Hyperplasia | 3 3 |
Mediastinal, Inflammation, | |
Suppurative | |
Mesenteric, Angiectasis | |
Mesenteric, Hyperplasia | 3 |
Renal, Hyperplasia | 3 |
Renal, Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 3 4 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + |
Cyst | |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
Femur, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Compression | |
Gliosis | 2 |
Infiltration Cellular, Lymphocyte | 1 |
Necrosis, Focal | 2 |
Artery, Meninges, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 1 2 2 2 1 1 1 2 1 1 |
Hyperplasia, Macrophage | 3 |
Infiltration Cellular, Mixed Cell | 2 1 |
Artery, Media, Hyperplasia | 2 2 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 9| 1| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 5| 6| 6| 7| 7| 4| 2| 3| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + |
Artery, Peritracheal Tissue, | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Suppurative | |
Metaplasia, Osseous | |
Necrosis, Multifocal | |
Nephropathy | 1 1 1 1 4 3 2 1 1 1 1 1 2 1|
Capsule, Inflammation, Suppurative | 2 |
Renal Tubule, Degeneration, Hyaline | 2 2 |
Renal Tubule, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 20 |
__________________________________________________________________________|____________|
Gallbladder | | 18 |
__________________________________________________________________________|____________|
Intestine Large | | 19 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 19 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 19 |
__________________________________________________________________________|____________|
Intestine Small | | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 19 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 19 |
Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Liver | | 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | | 1 3.0|
Congestion | | 1 4.0|
Cyst | | 1 4.0|
Hematopoietic Cell Proliferation | | 6 3.0|
Hyperplasia, Lymphoid | | 14 1.4|
Infarct | | 1 3.0|
Infiltration Cellular, Mixed Cell | | 10 2.1|
Inflammation, Multifocal | | 10 1.2|
Necrosis, Multifocal | | 2 1.5|
Bile Duct, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Inflammation, Suppurative | | 5 3.0|
__________________________________________________________________________|____________|
Pancreas | | 21 |
Atrophy, Diffuse | | 2 4.0|
Atrophy, Focal | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | | 20 |
__________________________________________________________________________|____________|
Stomach | | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 20 |
__________________________________________________________________________|____________|
Tooth | | 4 |
Incisor, Dysplasia | | 4 1.3|
Incisor, Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Aorta, Thrombosis | | 1 4.0|
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Heart | | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 21 |
Focal Cellular Change | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 21 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 19 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | | 22 |
Pars Distalis, Focal Cellular Change | | 2 1.5|
Pars Distalis, Necrosis, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | | 50 |
Degeneration, Cystic | | 6 1.2|
Follicular Cell, Hyperplasia | | 16 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Abdominal, Foreign Body | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | | 25 |
Angiectasis | | 2 2.0|
Hemorrhage | | 1 4.0|
Inflammation, Suppurative | | 10 3.9|
Thrombosis | | 1 4.0|
Follicle, Cyst | | 5 2.8|
Follicle, Cyst, Multiple | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | | 45 |
Angiectasis | | 4 2.8|
Hemorrhage | | 1 4.0|
Hydrometra | | 4 3.0|
Inflammation, Suppurative | | 7 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Thrombosis | | 1 2.0|
Endometrium, Hyperplasia, Cystic | | 40 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | | 20 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | | 24 |
Iliac, Hyperplasia | | 1 3.0|
Mediastinal, Angiectasis | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.5|
Mediastinal, Hyperplasia | | 3 3.0|
Mediastinal, Inflammation, | | |
Suppurative | | 1 3.0|
Mesenteric, Angiectasis | | 2 2.0|
Mesenteric, Hyperplasia | | 1 3.0|
Renal, Hyperplasia | | 1 3.0|
Renal, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 21 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | | 29 |
Hematopoietic Cell Proliferation | | 12 2.9|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | | 19 |
Cyst | | 1 1.0|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 20 |
__________________________________________________________________________|____________|
Skin | | 43 |
Inflammation, Chronic | | 5 1.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 20 |
Femur, Hyperostosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Compression | | 1 3.0|
Gliosis | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Necrosis, Focal | | 1 2.0|
Artery, Meninges, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | | 50 |
Congestion | | 2 3.0|
Hyperplasia, Lymphoid | | 16 1.6|
Hyperplasia, Macrophage | | 2 3.5|
Infiltration Cellular, Mixed Cell | | 3 2.0|
Artery, Media, Hyperplasia | | 10 1.5|
__________________________________________________________________________|____________|
Nose | | 20 |
__________________________________________________________________________|____________|
Trachea | | 20 |
Artery, Peritracheal Tissue, | | |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 50 |
Bacterium | | 1 1.0|
Infiltration Cellular, Mixed Cell | | 2 2.5|
Inflammation, Suppurative | | 2 2.5|
Metaplasia, Osseous | | 1 1.0|
Necrosis, Multifocal | | 1 2.0|
Nephropathy | | 20 1.5|
Capsule, Inflammation, Suppurative | | 1 2.0|
Renal Tubule, Degeneration, Hyaline | | 3 1.7|
Renal Tubule, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 19 |
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|
DAY ON TEST | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|
| 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3|
Basophilic Focus | |
Eosinophilic Focus | 2 |
Focal Cellular Change | 1 |
Hyperplasia, Lymphoid | 1 1 |
Hyperplasia, Multifocal | |
Infiltration Cellular, Mixed Cell | 1 2 3 |
Inflammation, Multifocal | 1 1 1 1 1 |
Necrosis, Multifocal | 1 1 2 1 2 1 1 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Focal Cellular Change | |
Necrosis, Focal | 2 |
Duct, Degeneration, Hyaline | |
Duct, Dilatation | |
Duct, Hyperplasia, Papillary | |
Duct, Metaplasia | |
Vein, Infiltration Cellular, Mixed | |
Cell | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + + + + +|
Atrophy, Focal | 3 |
Fibrosis, Focal | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Mucosa, Hyperplasia, Papillary | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|
DAY ON TEST | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|
| 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Focal | 1 |
Mineralization | |
Epithelium, Metaplasia, Squamous | |
Mucosa, Cyst | |
__________________________________________________________________________|
Tooth | + + + + + + + + |
Incisor, Dysplasia | 2 2 1 2 3 1 3 |
Incisor, Inflammation, Chronic | 3 |
Incisor, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Vacuolization Cytoplasmic, Focal | |
Extra Adrenal Tissue, Fibrosis | |
Subcapsular, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + M + +|
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | 2 |
Degeneration, Cystic | 1 1 1 2 1 1 |
Inflammation, Focal | 1 |
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | |
Spermatocele | |
__________________________________________________________________________|
Penis | + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|
DAY ON TEST | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|
| 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Necrosis | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + +|
Degeneration, Cystic | 3 3 4 2 3|
Inflammation, Suppurative | 3 4 2 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + M + + + + + + + + + + + + + +|
Dilatation | 2 3 2 |
Inflammation, Chronic | 2 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Germinal Epithelium, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | 3 |
Inguinal, Hyperplasia | 2 |
Inguinal, Inflammation, Chronic | 4 |
Mesenteric, Angiectasis | 1 3 2 2 3 1 3 1 2 |
Mesenteric, Depletion Lymphoid | 2 |
Mesenteric, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + M + + + + + M + + + + + + +|
Angiectasis | 2 |
Depletion Lymphoid | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Depletion Cellular | 2 |
Hematopoietic Cell Proliferation | 3 2 2 3 3 3 3 4 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Depletion Lymphoid | 2 |
Epithelial Cell, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M + M M M M M M M M M M M + M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 1 1 1 1 3 2 1 3 1 1 1 1 |
Ulcer | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|
DAY ON TEST | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|
| 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hair Follicle, Atrophy | |
Prepuce, Angiectasis | 3|
Prepuce, Fibrosis | |
Prepuce, Foreign Body | |
Prepuce, Inflammation, Chronic | 3|
Prepuce, Ulcer | 3 3 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Exudate | 3 |
Subcutaneous Tissue, Foreign Body | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Distal, Joint, Femur, Arthrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Hyperplasia, Lymphoid | 1 1 1 |
Hyperplasia, Macrophage | 2 |
Infiltration Cellular, Mixed Cell | 3 3 3 4 |
Alveolar Epithelium, Hyperplasia | |
Artery, Embolus | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 2 |
Nasolacrimal Duct, Foreign Body | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1 |
Congestion | 3 |
Hematopoietic Cell Proliferation | 1 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 7| 3| 6| 7| 1| 7| 7| 5| 4|
DAY ON TEST | 3| 3| 3| 1| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| 3| 5| 3| 3| 2| 3| 3| 9| 6|
| 1| 1| 1| 3| 5| 5| 1| 1| 1| 1| 1| 1| 1| 1| 2| 5| 1| 0| 0| 1| 6| 1| 1| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 1 3 |
Metaplasia, Osseous | 1 |
Nephropathy | 1 1 1 1 1 2 1 1 2 1 1 1 2 1 1 1 1 1 1 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | |
Renal Tubule, Vacuolization | |
Cytoplasmic | 1 1 1 1 1 1 1 1 2 2 1 2 1 1 1 2 1 1 1 1 1 2|
__________________________________________________________________________|
Urethra | |
Inflammation, Suppurative | |
Perforation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Inflammation, Chronic | 3 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|
| 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 |
Eosinophilic Focus | |
Focal Cellular Change | |
Hyperplasia, Lymphoid | |
Hyperplasia, Multifocal | 3 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Multifocal | 2 |
Necrosis, Multifocal | 2 2 2 |
Bile Duct, Cyst | 3 |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Focal Cellular Change | |
Necrosis, Focal | |
Duct, Degeneration, Hyaline | 3 |
Duct, Dilatation | 3 |
Duct, Hyperplasia, Papillary | 3 |
Duct, Metaplasia | 2 |
Vein, Infiltration Cellular, Mixed | |
Cell | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Fibrosis, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Mucosa, Hyperplasia, Papillary | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|
| 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Focal | |
Mineralization | 1 1 |
Epithelium, Metaplasia, Squamous | 1 |
Mucosa, Cyst | 1 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + |
Incisor, Dysplasia | 2 2 1 1 3 2 3 1 1 3 |
Incisor, Inflammation, Chronic | |
Incisor, Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Vacuolization Cytoplasmic, Focal | 1 |
Extra Adrenal Tissue, Fibrosis | 3 |
Subcapsular, Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 1 1 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration, Cystic | 2 2 2 1 1|
Inflammation, Focal | |
Follicular Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | |
Spermatocele | |
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|
| 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Necrosis | |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Degeneration, Cystic | 3 3 4 |
Inflammation, Suppurative | 2 2 4 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + M +|
Dilatation | 2 |
Inflammation, Chronic | 3 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Germinal Epithelium, Degeneration | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Neutrophilia | 2 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | |
Inguinal, Hyperplasia | 2 |
Inguinal, Inflammation, Chronic | |
Mesenteric, Angiectasis | 1 1 1 2 3 2 1 1 1 |
Mesenteric, Depletion Lymphoid | |
Mesenteric, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M M M + M + + + + + + + + M +|
Angiectasis | |
Depletion Lymphoid | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Cellular | |
Hematopoietic Cell Proliferation | 4 2 3 2 3 3|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Depletion Lymphoid | |
Epithelial Cell, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M + M M M M + M M M M + + M M + M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 3 2 2 2 3 3 2 2|
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|
| 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hair Follicle, Atrophy | 2 |
Prepuce, Angiectasis | |
Prepuce, Fibrosis | 3 |
Prepuce, Foreign Body | |
Prepuce, Inflammation, Chronic | 3 3 |
Prepuce, Ulcer | 3 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Exudate | |
Subcutaneous Tissue, Foreign Body | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Distal, Joint, Femur, Arthrosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | 2 4 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Artery, Embolus | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 1 |
Nasolacrimal Duct, Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1 |
Congestion | 2 |
Hematopoietic Cell Proliferation | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 0| 7| 7| 6| 6| 1| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 6| 3| 5| 3| 3| 5| 0| 2| 3| 3| 3| 3| 3| 0| 0| 3| 8| 3| 3| 3| 3| 9|
| 2| 8| 2| 7| 2| 4| 2| 2| 4| 2| 3| 2| 2| 2| 2| 5| 2| 9| 2| 6| 5| 5| 5| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATD | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 1 |
Metaplasia, Osseous | |
Nephropathy | 1 2 1 1 1 1 2 1 1 1 1 2 1 1 2 2 1 2 1 1|
Renal Tubule, Dilatation | 3 2 |
Renal Tubule, Necrosis | |
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 2 1 1 1 2 2 2 2 1 1 1 1 1 1 2 1 2 2 1 2 2 1 2 1|
__________________________________________________________________________|
Urethra | |
Inflammation, Suppurative | |
Perforation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 3 |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 4| 4| 4| 4| 6| 4| 4| | |
DAY ON TEST | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6| | |
| 0| 6| 6| 5| 5| 5| 5| 9| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | M M + + | 51 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 54 |
__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Angiectasis | | 1 3.0|
Basophilic Focus | | 1 2.0|
Eosinophilic Focus | 2 | 2 2.0|
Focal Cellular Change | | 1 1.0|
Hyperplasia, Lymphoid | | 2 1.0|
Hyperplasia, Multifocal | | 1 3.0|
Infiltration Cellular, Mixed Cell | | 4 2.0|
Inflammation, Multifocal | | 6 1.2|
Necrosis, Multifocal | | 10 1.5|
Bile Duct, Cyst | | 1 3.0|
Bile Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
Fibrosis, Focal | | 1 2.0|
Focal Cellular Change | 1 | 1 1.0|
Necrosis, Focal | | 1 2.0|
Duct, Degeneration, Hyaline | | 1 3.0|
Duct, Dilatation | | 1 3.0|
Duct, Hyperplasia, Papillary | | 1 3.0|
Duct, Metaplasia | | 1 2.0|
Vein, Infiltration Cellular, Mixed | | |
Cell | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 53 |
Atrophy, Focal | | 1 3.0|
Fibrosis, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 4| 4| 4| 4| 6| 4| 4| | |
DAY ON TEST | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6| | |
| 0| 6| 6| 5| 5| 5| 5| 9| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
Mineralization | | 1 2.0|
Mucosa, Hyperplasia, Papillary | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
Inflammation, Focal | | 1 1.0|
Mineralization | | 2 1.0|
Epithelium, Metaplasia, Squamous | | 1 1.0|
Mucosa, Cyst | | 2 1.5|
__________________________________________________________________________|____________|
Tooth | + | 21 |
Incisor, Dysplasia | 1 | 18 1.9|
Incisor, Inflammation, Chronic | | 1 3.0|
Incisor, Inflammation, Suppurative | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 54 |
Inflammation, Chronic | | 3 1.0|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 54 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 54 |
Cyst | | 1 3.0|
Vacuolization Cytoplasmic, Focal | | 1 1.0|
Extra Adrenal Tissue, Fibrosis | | 1 3.0|
Subcapsular, Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 54 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 53 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 52 |
Pars Distalis, Hyperplasia, Focal | | 5 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 53 |
Cyst | | 1 2.0|
Degeneration, Cystic | 1 | 12 1.3|
Inflammation, Focal | | 1 1.0|
Follicular Cell, Hyperplasia | | 5 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 4| 4| 4| 4| 6| 4| 4| | |
DAY ON TEST | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6| | |
| 0| 6| 6| 5| 5| 5| 5| 9| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 54 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
Spermatocele | 3 | 1 3.0|
__________________________________________________________________________|____________|
Penis | + | 5 |
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Necrosis | 3 | 2 3.5|
__________________________________________________________________________|____________|
Preputial Gland | | 12 |
Degeneration, Cystic | | 8 3.1|
Inflammation, Suppurative | | 8 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + | 53 |
Inflammation, Chronic | 3 3 2 | 6 2.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 52 |
Dilatation | | 4 2.3|
Inflammation, Chronic | 3 2 2 | 9 2.7|
__________________________________________________________________________|____________|
Testes | + + + + | 54 |
Mineralization | | 1 2.0|
Germinal Epithelium, Degeneration | | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Neutrophilia | | 1 2.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 54 |
Iliac, Hyperplasia | | 1 3.0|
Inguinal, Hyperplasia | | 2 2.0|
Inguinal, Inflammation, Chronic | | 1 4.0|
Mesenteric, Angiectasis | 2 | 19 1.7|
Mesenteric, Depletion Lymphoid | | 1 2.0|
Mesenteric, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M | 45 |
Angiectasis | 2 | 2 2.0|
Depletion Lymphoid | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 4| 4| 4| 4| 6| 4| 4| | |
DAY ON TEST | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6| | |
| 0| 6| 6| 5| 5| 5| 5| 9| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + | 54 |
Angiectasis | | 1 2.0|
Depletion Cellular | | 1 2.0|
Hematopoietic Cell Proliferation | 2 3 | 17 2.8|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M | 53 |
Cyst | | 1 1.0|
Depletion Lymphoid | | 1 2.0|
Epithelial Cell, Hyperplasia, Cystic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M | 13 |
__________________________________________________________________________|____________|
Skin | + + + + | 54 |
Inflammation, Chronic | 2 | 25 1.8|
Ulcer | | 4 2.8|
Hair Follicle, Atrophy | | 1 2.0|
Prepuce, Angiectasis | | 1 3.0|
Prepuce, Fibrosis | | 1 3.0|
Prepuce, Foreign Body | 2 | 1 2.0|
Prepuce, Inflammation, Chronic | 3 2 | 5 2.8|
Prepuce, Ulcer | 3 2 | 5 2.8|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
Subcutaneous Tissue, Exudate | | 1 3.0|
Subcutaneous Tissue, Foreign Body | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 54 |
Distal, Joint, Femur, Arthrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 54 |
Gliosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Congestion | 2 | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 4| 4| 4| 4| 6| 4| 4| | |
DAY ON TEST | 2| 3| 8| 6| 6| 6| 6| 4| 6| 6| | |
| 0| 6| 6| 5| 5| 5| 5| 9| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 4 1.0|
Hyperplasia, Macrophage | | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 2 | 8 2.9|
Alveolar Epithelium, Hyperplasia | | 2 1.0|
Artery, Embolus | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + | 54 |
Lumen, Exudate | | 2 1.5|
Nasolacrimal Duct, Foreign Body | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 54 |
Bacterium | | 2 1.0|
Congestion | 2 | 3 2.3|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Suppurative | | 4 1.8|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | | 39 1.2|
Renal Tubule, Dilatation | 2 2 2 | 6 2.2|
Renal Tubule, Necrosis | 1 | 1 1.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 2 2 2 1 | 51 1.4|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
Perforation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 53 |
Congestion | | 1 3.0|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|
| 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + A + + + + M M + + + M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A A + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + A A + + + + + + +|
Mucosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + + + + A + + + + A A + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + A + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Bacterium | |
Basophilic Focus | |
Congestion | |
Eosinophilic Focus | |
Fibrosis | 4 2 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | 2 |
Infarct | 3 |
Infiltration Cellular, Mixed Cell | 2 1 |
Inflammation, Multifocal | 1 1 1 2 1 1 2 |
Necrosis, Multifocal | 2 1 2 |
Pigmentation | 2 |
Artery, Media, Hypertrophy | |
Centrilobular, Necrosis | |
Centrilobular, Vacuolization Nuclear | |
Hepatocyte, Centrilobular, | |
Degeneration, Hyaline | 2 2 2 1 2 1 2 2 2 2 1 1 3 2 2 3 2 3 2|
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic | |
Inflammation, Granulomatous | 4 |
Inflammation, Suppurative | 2 2 4 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|
| 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | |
Epithelium, Vacuolization | |
Cytoplasmic, Multifocal | |
Mucosa, Erosion | |
__________________________________________________________________________|
Tooth | + + + + + + |
Incisor, Dysplasia | 1 2 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Focal | 1 |
Inflammation, Suppurative | |
Atrium, Thrombosis, Multiple | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Hyperplasia, Focal | |
Infiltration Cellular, Mixed Cell | |
Extra Adrenal Tissue, Inflammation, | |
Suppurative | |
Subcapsular, Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Infiltration Cellular, Mixed Cell | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 1 1 1 1|
Follicular Cell, Hyperplasia | 2 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|
| 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ductus Deferens | |
Inflammation, Chronic | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Penis | + + + |
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + +|
Degeneration, Cystic | 2 2 2 2 |
Inflammation, Suppurative | 4 2 1 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Edema | 2 |
Inflammation, Chronic | 3 3 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2|
Inflammation, Chronic | 2 3|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | 1 |
Necrosis, Multifocal | |
Germinal Epithelium, Degeneration | 1 3 2|
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular, Focal | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | |
Inguinal, Hyperplasia, Lymphoid | 2 2 |
Inguinal, Hyperplasia | |
Inguinal, Inflammation, Chronic | |
Mesenteric, Angiectasis | 1 2 2 1 2 2 2 3 2 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 |
Mesenteric, Hyperplasia | 2 1 |
Mesenteric, Hyperplasia, Reticulum | |
Cell | |
Mesenteric, Inflammation, Chronic, | |
Granulomatous | 4 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|
| 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Inflammation, Suppurative| |
Mesenteric, Thrombosis | 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Cellular | |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 4 3 2 2 4 3 4 3 4 2 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Cyst | 2 |
Degeneration, Cystic | |
Depletion Lymphoid | 3 |
Hyperplasia, Reticulum Cell | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M + + M + + + M M + M + M + M + + M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Exudate | 2 |
Inflammation, Chronic | 3 2 2 1 2 1 1 2 1 2 2 1 |
Ulcer | 3 3 3 3 |
Prepuce, Inflammation, Chronic | 3 |
Prepuce, Ulcer | 3 |
Subcutaneous Tissue, Lymphatic, | |
Angiectasis | 2 |
Tail, Subcutaneous Tissue, | |
Inflammation, Granulomatous | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Congestion | 3 2 |
Foreign Body | |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|
| 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 1 1 1|
Hyperplasia, Macrophage | 4 |
Infiltration Cellular, Mixed Cell | 3 |
Inflammation, Granulomatous | |
Pigmentation | 4 |
Interstitium, Inflammation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 |
Bacterium | 3 2 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Suppurative | 3 |
Metaplasia, Osseous | 1 |
Mineralization | 3 |
Necrosis, Focal | 3 |
Nephropathy | 1 1 2 1 2 1 1 1 1 1 1 3 1 2 1 2 2 2 1 1|
Pelvis, Crystals | |
Pelvis, Dilatation | |
Pelvis, Inflammation, Chronic | |
Pelvis, Mineralization | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Crystals | 2 1 2 3 1 |
Renal Tubule, Degeneration, Hyaline | 3 |
Renal Tubule, Dilatation | 1 3 2 1 3 2 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2|
Renal Tubule, Epithelium, Necrosis | 2 |
__________________________________________________________________________|
Urethra | + + + + + + |
Hemorrhage | |
Inflammation, Suppurative | 3 4 |
Bulbourethral Gland, Dilatation | |
Lumen, Crystals | 3 2 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 1| 2| 7| 7| 7| 7| 3| 6| 7| 5| 7| 2| 5| 6| 6| 4| 5| 6| 6| 7|
DAY ON TEST | 3| 3| 4| 3| 3| 2| 1| 3| 3| 3| 3| 1| 9| 3| 9| 3| 4| 9| 5| 8| 9| 9| 6| 8| 3|
| 1| 1| 4| 1| 1| 6| 5| 1| 1| 1| 2| 7| 7| 2| 0| 2| 1| 5| 4| 1| 8| 7| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic | 4 3 |
Ulcer | |
Artery, Serosa, Mineralization | 2 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|
| 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + A + + + + + I + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + A + + + + + M + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + A + M + + + M + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + A + M + + + M + + +|
Mucosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + A + + + + + M M + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
Bacterium | 1 1 |
Basophilic Focus | 3 |
Congestion | 3 |
Eosinophilic Focus | |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
Infarct | |
Infiltration Cellular, Mixed Cell | 2 2 1 2 2 2 |
Inflammation, Multifocal | 1 1 2 1 2 1 |
Necrosis, Multifocal | 2 2 3 2 |
Pigmentation | 2 |
Artery, Media, Hypertrophy | 2 |
Centrilobular, Necrosis | |
Centrilobular, Vacuolization Nuclear | |
Hepatocyte, Centrilobular, | |
Degeneration, Hyaline | 2 2 2 2 2 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 2 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|
| 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 2 |
Epithelium, Vacuolization | |
Cytoplasmic, Multifocal | 2 |
Mucosa, Erosion | |
__________________________________________________________________________|
Tooth | + + + + + + + + + +|
Incisor, Dysplasia | 2 2 1 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Focal | |
Inflammation, Suppurative | 2 2 2 |
Atrium, Thrombosis, Multiple | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Hyperplasia, Focal | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Extra Adrenal Tissue, Inflammation, | |
Suppurative | 3 |
Subcapsular, Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Infiltration Cellular, Mixed Cell | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + M + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + M + + + + + + + + M + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Degeneration, Cystic | 1 |
Follicular Cell, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|
| 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Ductus Deferens | + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Penis | + + + |
Hyperplasia | 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Degeneration, Cystic | 3 3 |
Inflammation, Suppurative | 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Edema | |
Inflammation, Chronic | 3 3 4 3 2 2 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 3 |
Inflammation, Chronic | 3 2 3 1 1 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Mineralization | 2 2 |
Necrosis, Multifocal | 2 |
Germinal Epithelium, Degeneration | 2 3 |
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular, Focal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | 2 3 3 |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia | 2 |
Inguinal, Inflammation, Chronic | 2 |
Mesenteric, Angiectasis | 1 3 3 2 4 2 2 2 1 3 2|
Mesenteric, Hematopoietic Cell | |
Proliferation | |
Mesenteric, Hyperplasia, Lymphoid | 2 |
Mesenteric, Hyperplasia | 3 |
Mesenteric, Hyperplasia, Reticulum | |
Cell | |
Mesenteric, Inflammation, Chronic, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|
| 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Inflammation, Suppurative| 2 |
Mesenteric, Thrombosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + M + + + + + + + + M + + +|
Hyperplasia, Lymphoid | 2 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Congestion | 2 |
Depletion Cellular | |
Hematopoietic Cell Proliferation | 2 3 3 3 3 3 3 3 3 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + M +|
Atypia Cellular | 2 |
Cyst | |
Degeneration, Cystic | 2 |
Depletion Lymphoid | 2 2 1 1 2 2 |
Hyperplasia, Reticulum Cell | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M M + + + M M + + M + M M M + + + + + + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Exudate | |
Inflammation, Chronic | 3 3 3 1 2 3|
Ulcer | 3 3 3 3 1|
Prepuce, Inflammation, Chronic | 3 |
Prepuce, Ulcer | 3 4 |
Subcutaneous Tissue, Lymphatic, | |
Angiectasis | |
Tail, Subcutaneous Tissue, | |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1 2 |
Congestion | 3 |
Foreign Body | 1 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|
| 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | 2 3 3 2 2 2 2 |
Inflammation, Granulomatous | |
Pigmentation | |
Interstitium, Inflammation | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Bacterium | 2 3 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Suppurative | 1 3 3 |
Metaplasia, Osseous | |
Mineralization | |
Necrosis, Focal | 3 |
Nephropathy | 2 2 2 2 2 1 2 2 1 1 1 3 2 1 2 1|
Pelvis, Crystals | 3|
Pelvis, Dilatation | 2 2 |
Pelvis, Inflammation, Chronic | 2 1 |
Pelvis, Mineralization | 2 2 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2|
Renal Tubule, Crystals | 2 1 2 |
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Dilatation | 3 2 2 2 1 2 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 2 2 1 1 1 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2|
Renal Tubule, Epithelium, Necrosis | |
__________________________________________________________________________|
Urethra | + + + + + + + + + + |
Hemorrhage | 3 |
Inflammation, Suppurative | 3 1 2 2 4 |
Bulbourethral Gland, Dilatation | 3 |
Lumen, Crystals | 2 1 2 3 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | 3 3 |
Calculus Micro Observation Only | 3|
Hyperplasia, Lymphoid | 2|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 5| 0| 1| 1| 1| 6| 1| 7| 7| 7| 7| 0| 0| 1| 7| 7| 7| 1| 1| 7| 7|
DAY ON TEST | 0| 2| 3| 0| 1| 6| 4| 4| 5| 8| 6| 3| 3| 3| 3| 9| 9| 0| 3| 3| 3| 5| 6| 3| 3|
| 9| 7| 2| 9| 9| 0| 5| 9| 0| 1| 8| 2| 2| 2| 2| 1| 8| 1| 2| 5| 5| 4| 1| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 4 2 3 2 3 |
Ulcer | 3 |
Artery, Serosa, Mineralization | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6| | |
| 6| 3| 2| 5| 5| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
__________________________________________________________________________|____________|
Gallbladder | + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 49 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 48 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + | 46 |
Mucosa, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + | 45 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Autolysis | | 1 1.0|
Bacterium | | 2 1.0|
Basophilic Focus | X | 2 3.0|
Congestion | | 1 3.0|
Eosinophilic Focus | X | 1 |
Fibrosis | | 2 3.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Lymphoid | | 2 2.0|
Infarct | | 1 3.0|
Infiltration Cellular, Mixed Cell | | 8 1.8|
Inflammation, Multifocal | | 13 1.3|
Necrosis, Multifocal | 1 | 8 1.9|
Pigmentation | 1 | 3 1.7|
Artery, Media, Hypertrophy | | 1 2.0|
Centrilobular, Necrosis | 1 | 1 1.0|
Centrilobular, Vacuolization Nuclear | 2 | 1 2.0|
Hepatocyte, Centrilobular, | | |
Degeneration, Hyaline | 2 2 1 2 | 36 2.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6| | |
| 6| 3| 2| 5| 5| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 3 2.7|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
Inflammation, Chronic, Focal | | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 54 |
__________________________________________________________________________|____________|
Stomach | + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
Mucosa, Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
Inflammation, Focal | | 1 2.0|
Epithelium, Vacuolization | | |
Cytoplasmic, Multifocal | | 1 2.0|
Mucosa, Erosion | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + | 18 |
Incisor, Dysplasia | 2 1 | 15 1.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 54 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Focal | | 1 1.0|
Inflammation, Suppurative | | 3 2.0|
Atrium, Thrombosis, Multiple | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 54 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 54 |
Focal Cellular Change | 1 | 1 1.0|
Hyperplasia, Focal | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Extra Adrenal Tissue, Inflammation, | | |
Suppurative | | 1 3.0|
Subcapsular, Hyperplasia, Focal | | 4 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 53 |
Hyperplasia, Focal | 1 | 1 1.0|
Infiltration Cellular, Mixed Cell | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 49 |
Pars Distalis, Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6| | |
| 6| 3| 2| 5| 5| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 53 |
Degeneration, Cystic | | 9 1.0|
Follicular Cell, Hyperplasia | 1 | 9 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Ductus Deferens | | 1 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + | 54 |
Granuloma Sperm | | 1 4.0|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Penis | | 6 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | | 12 |
Degeneration, Cystic | | 6 2.3|
Inflammation, Suppurative | | 7 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + | 54 |
Dilatation | | 1 2.0|
Edema | | 1 2.0|
Inflammation, Chronic | | 10 3.1|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 54 |
Dilatation | | 4 2.3|
Inflammation, Chronic | | 8 2.4|
__________________________________________________________________________|____________|
Testes | + + + + | 54 |
Inflammation, Chronic | | 1 3.0|
Mineralization | | 3 1.7|
Necrosis, Multifocal | | 1 2.0|
Germinal Epithelium, Degeneration | | 5 2.2|
Interstitial Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6| | |
| 6| 3| 2| 5| 5| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atypia Cellular, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 54 |
Iliac, Hyperplasia | | 3 2.7|
Inguinal, Hyperplasia, Lymphoid | | 2 2.0|
Inguinal, Hyperplasia | | 1 2.0|
Inguinal, Inflammation, Chronic | | 1 2.0|
Mesenteric, Angiectasis | 3 2 | 22 2.1|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Mesenteric, Hyperplasia, Lymphoid | | 2 2.0|
Mesenteric, Hyperplasia | | 3 2.0|
Mesenteric, Hyperplasia, Reticulum | | |
Cell | 2 | 1 2.0|
Mesenteric, Inflammation, Chronic, | | |
Granulomatous | | 1 4.0|
Mesenteric, Inflammation, Suppurative| | 1 2.0|
Mesenteric, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 51 |
Hyperplasia, Lymphoid | | 4 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + | 53 |
Congestion | | 1 2.0|
Depletion Cellular | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 28 2.8|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + | 51 |
Atypia Cellular | | 1 2.0|
Cyst | | 1 2.0|
Degeneration, Cystic | | 1 2.0|
Depletion Lymphoid | | 7 1.9|
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 29 |
__________________________________________________________________________|____________|
Skin | + + + + | 54 |
Erosion | | 1 2.0|
Exudate | | 1 2.0|
Inflammation, Chronic | | 18 1.9|
Ulcer | | 9 2.8|
Prepuce, Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6| | |
| 6| 3| 2| 5| 5| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Prepuce, Ulcer | | 3 3.3|
Subcutaneous Tissue, Lymphatic, | | |
Angiectasis | | 1 2.0|
Tail, Subcutaneous Tissue, | | |
Inflammation, Granulomatous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 54 |
Femur, Hyperostosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 54 |
Congestion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Bacterium | | 2 1.5|
Congestion | | 3 2.7|
Foreign Body | | 1 1.0|
Hemorrhage | | 2 1.5|
Hyperplasia, Lymphoid | | 4 1.0|
Hyperplasia, Macrophage | | 1 4.0|
Infiltration Cellular, Mixed Cell | | 8 2.4|
Inflammation, Granulomatous | 3 | 1 3.0|
Pigmentation | | 1 4.0|
Interstitium, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + | 54 |
__________________________________________________________________________|____________|
Trachea | + + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 54 |
Atrophy, Focal | | 1 3.0|
Bacterium | | 4 2.5|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Suppurative | | 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 6| 2| 3| 3| 6| 6| 6| 6| 6| | |
| 6| 3| 2| 5| 5| 3| 3| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.5% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Metaplasia, Osseous | | 1 1.0|
Mineralization | | 1 3.0|
Necrosis, Focal | | 2 3.0|
Nephropathy | 1 2 | 38 1.5|
Pelvis, Crystals | | 1 3.0|
Pelvis, Dilatation | | 2 2.0|
Pelvis, Inflammation, Chronic | | 2 1.5|
Pelvis, Mineralization | | 2 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 2.0|
Renal Tubule, Crystals | | 8 1.8|
Renal Tubule, Degeneration, Hyaline | | 1 3.0|
Renal Tubule, Dilatation | 1 | 13 1.9|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 2 2 2 2 | 52 1.8|
Renal Tubule, Epithelium, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + + | 18 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 7 2.7|
Bulbourethral Gland, Dilatation | | 1 3.0|
Lumen, Crystals | 2 2 | 12 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 54 |
Calculus Gross Observation | | 2 3.0|
Calculus Micro Observation Only | 3 | 2 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 8 2.9|
Ulcer | | 1 3.0|
Artery, Serosa, Mineralization | | 1 2.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 0| 7| 6| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 4| 3| 6| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 2| 5| 3| 2| 2| 2| 2| 7| 7| 2| 2| 2| 2| 2| 1| 5| 5| 2| 2| 6| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | A + + M + + + + M |
Inflammation | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | 4 |
Focal Cellular Change | 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Lymphoid | 1 1 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Multifocal | 1 1 1 1 1 1 1 1 |
Necrosis, Multifocal | 2 1 2 |
Pigmentation | |
Centrilobular, Necrosis | |
Hepatocyte, Centrilobular, | |
Degeneration, Hyaline | 2 1 1 1 1 2 1 1 2 1 2 1 2 1|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + |
Inflammation, Focal | 1 |
Mineralization | 2 |
__________________________________________________________________________|
Tooth | |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 0| 7| 6| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 4| 3| 6| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 2| 5| 3| 2| 2| 2| 2| 7| 7| 2| 2| 2| 2| 2| 1| 5| 5| 2| 2| 6| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Subcapsular, Hyperplasia, Focal | 2 2 |
Unilateral, Atrophy | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + |
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + M |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration, Cystic | 1 1 1 1 1 1 |
Fibrosis | |
Follicle, Cyst | 2 1|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Adventitia, Hemorrhage | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + |
Granuloma Sperm | |
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic | 4 |
Necrosis | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + |
Degeneration, Cystic | 2 4 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + |
Inflammation, Chronic | 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
Dilatation | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + |
Mineralization | 2 |
Germinal Epithelium, Degeneration | 2 |
Tunic, Proliferation Connective | |
Tissue | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 0| 7| 6| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 4| 3| 6| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 2| 5| 3| 2| 2| 2| 2| 7| 7| 2| 2| 2| 2| 2| 1| 5| 5| 2| 2| 6| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Iliac, Hyperplasia | |
Inguinal, Hyperplasia | 1 |
Mesenteric, Angiectasis | 2 3 2 2 2 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 3 3 4 2 3 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + |
Depletion Lymphoid | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M M + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Melanocyte | 2 |
Inflammation, Chronic | 1 2 2 1 1 2 2 1 2 2 2|
Metaplasia, Osseous | |
Ulcer | 4 3 4 |
Hair Follicle, Atrophy | 2 2|
Prepuce, Inflammation, Chronic | 3 |
Prepuce, Ulcer | 3 3 |
Subcutaneous Tissue, Edema | 2 |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Macrophage | 2 |
Infiltration Cellular, Mixed Cell | 1 1 3 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + A + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 0| 7| 6| 6| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 3| 3| 3| 4| 3| 6| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 2| 5| 3| 2| 2| 2| 2| 7| 7| 2| 2| 2| 2| 2| 1| 5| 5| 2| 2| 6| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Bacterium | |
Congestion | 3 |
Inflammation, Suppurative | |
Metaplasia, Osseous | 1 |
Necrosis | |
Nephropathy | 2 2 1 2 2 1 1 2 1 2 1 1 1 1 1 2 1 2 2 2|
Papilla, Necrosis | |
Renal Tubule, Dilatation | 2 3 2 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Mineralization | |
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Urethra | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | 1 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 3| 7| 7| 3| 7| 7| 1| 7| 7| 6| 6| 7| 3| 3| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 1| 8| 8| 3| 3| 8| 3| 3| 2| 3| 3| 5| 9| 3| 8| 8| 3| 3| 3| 3| 3| 1| 3|
| 1| 0| 3| 4| 3| 1| 1| 4| 1| 1| 1| 5| 5| 4| 7| 5| 4| 4| 5| 5| 5| 5| 5| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + M A + M + + + + M |
Inflammation | 2 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + + + + A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + A A + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + A A + + + + A + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A A + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + M A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A A + + + + A + + |
__________________________________________________________________________|
Liver | + + + + + + + A + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Multifocal | 1 1 1 1 1 1 2|
Necrosis, Multifocal | 2 |
Pigmentation | 1 |
Centrilobular, Necrosis | 3 4 |
Hepatocyte, Centrilobular, | |
Degeneration, Hyaline | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + A A + + + + + + |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + M A + + + + + + |
__________________________________________________________________________|
Stomach | + + + A + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + |
Inflammation, Focal | |
Mineralization | 2 |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + M + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + M + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 3| 7| 7| 3| 7| 7| 1| 7| 7| 6| 6| 7| 3| 3| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 1| 8| 8| 3| 3| 8| 3| 3| 2| 3| 3| 5| 9| 3| 8| 8| 3| 3| 3| 3| 3| 1| 3|
| 1| 0| 3| 4| 3| 1| 1| 4| 1| 1| 1| 5| 5| 4| 7| 5| 4| 4| 5| 5| 5| 5| 5| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Subcapsular, Hyperplasia, Focal | |
Unilateral, Atrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + A A + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + |
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + M M + + + + + |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Degeneration, Cystic | 1 1 1 2 1 2 |
Fibrosis | 1 |
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Adventitia, Hemorrhage | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + |
Granuloma Sperm | 3 |
__________________________________________________________________________|
Penis | + + + |
Inflammation, Chronic | 3 3 |
Necrosis | |
__________________________________________________________________________|
Preputial Gland | + + + |
Degeneration, Cystic | 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + |
Inflammation, Chronic | 4 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + |
Dilatation | 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + |
Mineralization | |
Germinal Epithelium, Degeneration | |
Tunic, Proliferation Connective | |
Tissue | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 3| 7| 7| 3| 7| 7| 1| 7| 7| 6| 6| 7| 3| 3| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 1| 8| 8| 3| 3| 8| 3| 3| 2| 3| 3| 5| 9| 3| 8| 8| 3| 3| 3| 3| 3| 1| 3|
| 1| 0| 3| 4| 3| 1| 1| 4| 1| 1| 1| 5| 5| 4| 7| 5| 4| 4| 5| 5| 5| 5| 5| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + M + + M + + + + + + + +|
Iliac, Hyperplasia | 3 |
Inguinal, Hyperplasia | 2 2 |
Mesenteric, Angiectasis | 1 3 2 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M M + + + M M + |
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 4 3 2 3 2 2 4 3 2 3 3 2|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + + M M + + + + + + |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M + + M + M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 3 |
Hyperplasia, Melanocyte | |
Inflammation, Chronic | 1 3 1 2 1 1 1 1 3 3 2 2 1 |
Metaplasia, Osseous | 2 |
Ulcer | 3 3 |
Hair Follicle, Atrophy | |
Prepuce, Inflammation, Chronic | 2 |
Prepuce, Ulcer | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Congestion | 3 3 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Macrophage | 2 |
Infiltration Cellular, Mixed Cell | 2 3 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 3| 7| 7| 3| 7| 7| 1| 7| 7| 6| 6| 7| 3| 3| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 2| 1| 8| 8| 3| 3| 8| 3| 3| 2| 3| 3| 5| 9| 3| 8| 8| 3| 3| 3| 3| 3| 1| 3|
| 1| 0| 3| 4| 3| 1| 1| 4| 1| 1| 1| 5| 5| 4| 7| 5| 4| 4| 5| 5| 5| 5| 5| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.25% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Bacterium | 3 |
Congestion | |
Inflammation, Suppurative | 4 |
Metaplasia, Osseous | 1 |
Necrosis | 4 |
Nephropathy | 2 1 1 1 1 1 1 2 2 1 1 1 1 1 2 1 2 2|
Papilla, Necrosis | 4 |
Renal Tubule, Dilatation | 2 2 |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Mineralization | 1 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 2 1 2 2 2 2 2 1 2 2 2 1 1 1 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Urethra | + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | 2 1 |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 5| 7| 0| 4| 4| 7| 4| | |
DAY ON TEST | 6| 6| 6| 9| 3| 9| 6| 6| 3| 6| | |
| 3| 3| 3| 8| 5| 3| 3| 3| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 22 |
__________________________________________________________________________|____________|
Gallbladder | + + | 16 |
Inflammation | | 1 2.0|
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + | 21 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 21 |
__________________________________________________________________________|____________|
Intestine Small | + M | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M | 17 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M | 19 |
__________________________________________________________________________|____________|
Liver | + + + + | 53 |
Congestion | | 1 3.0|
Cyst | | 1 4.0|
Focal Cellular Change | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia, Lymphoid | | 3 1.0|
Infiltration Cellular, Mixed Cell | | 2 2.0|
Inflammation, Multifocal | 1 | 16 1.1|
Necrosis, Multifocal | | 4 1.8|
Pigmentation | | 1 1.0|
Centrilobular, Necrosis | | 2 3.5|
Hepatocyte, Centrilobular, | | |
Degeneration, Hyaline | 1 1 2 | 24 1.3|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + | 21 |
Duct, Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + | 21 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 21 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 21 |
Inflammation, Focal | | 1 1.0|
Mineralization | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Incisor, Dysplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 5| 7| 0| 4| 4| 7| 4| | |
DAY ON TEST | 6| 6| 6| 9| 3| 9| 6| 6| 3| 6| | |
| 3| 3| 3| 8| 5| 3| 3| 3| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 22 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 22 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 21 |
Subcapsular, Hyperplasia, Focal | | 2 2.0|
Unilateral, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 21 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M | 22 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + M | 17 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 54 |
Cyst | | 2 2.0|
Degeneration, Cystic | 2 | 13 1.2|
Fibrosis | | 1 1.0|
Follicle, Cyst | 1 | 4 1.3|
Follicular Cell, Hyperplasia | | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Adventitia, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + | 22 |
Granuloma Sperm | | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 4 |
Inflammation, Chronic | | 3 3.3|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | | 7 |
Degeneration, Cystic | | 3 3.0|
Inflammation, Suppurative | | 2 4.0|
__________________________________________________________________________|____________|
Prostate | + + | 22 |
Inflammation, Chronic | | 5 3.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 23 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 5| 7| 0| 4| 4| 7| 4| | |
DAY ON TEST | 6| 6| 6| 9| 3| 9| 6| 6| 3| 6| | |
| 3| 3| 3| 8| 5| 3| 3| 3| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | 4 | 2 4.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + | 22 |
Mineralization | | 1 2.0|
Germinal Epithelium, Degeneration | | 1 2.0|
Tunic, Proliferation Connective | | |
Tissue | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 22 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 27 |
Iliac, Hyperplasia | | 1 3.0|
Inguinal, Hyperplasia | 1 | 4 1.5|
Mesenteric, Angiectasis | | 11 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 17 |
__________________________________________________________________________|____________|
Spleen | + + + + | 53 |
Hematopoietic Cell Proliferation | 3 | 25 2.8|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + | 19 |
Depletion Lymphoid | | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M | 11 |
__________________________________________________________________________|____________|
Skin | + + + + | 43 |
Fibrosis | | 1 3.0|
Hyperplasia, Melanocyte | | 1 2.0|
Inflammation, Chronic | 1 3 2 | 27 1.7|
Metaplasia, Osseous | | 1 2.0|
Ulcer | | 5 3.4|
Hair Follicle, Atrophy | | 2 2.0|
Prepuce, Inflammation, Chronic | | 2 2.5|
Prepuce, Ulcer | 3 | 3 3.0|
Subcutaneous Tissue, Edema | | 1 2.0|
Subcutaneous Tissue, Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 22 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 5| 7| 0| 4| 4| 7| 4| | |
DAY ON TEST | 6| 6| 6| 9| 3| 9| 6| 6| 3| 6| | |
| 3| 3| 3| 8| 5| 3| 3| 3| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 22 |
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + | 32 |
Congestion | | 3 2.7|
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia, Macrophage | | 2 2.0|
Infiltration Cellular, Mixed Cell | 1 | 7 1.9|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + | 21 |
__________________________________________________________________________|____________|
Trachea | + + | 22 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 53 |
Atrophy, Focal | 3 | 1 3.0|
Bacterium | | 1 3.0|
Congestion | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Metaplasia, Osseous | | 2 1.0|
Necrosis | | 1 4.0|
Nephropathy | 2 1 1 | 41 1.4|
Papilla, Necrosis | | 1 4.0|
Renal Tubule, Dilatation | 3 | 7 2.3|
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Mineralization | | 1 1.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 1 2 2 2 | 48 1.8|
__________________________________________________________________________|____________|
Urethra | | 2 |
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 53 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
Inflammation, Chronic | | 6 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 7| 6| 6| 7| 7| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 4| 7| 5| 3| 0| 3| 2| 5| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 3| 3|
| 1| 1| 1| 1| 4| 1| 8| 4| 1| 1| 2| 7| 4| 2| 2| 8| 2| 5| 2| 2| 9| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + A + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + A A + |
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + |
Prolapse | |
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A A + |
Perforation | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + A + + + + + + + + +|
Basophilic Focus | 3 |
Fatty Change | |
Hematopoietic Cell Proliferation | 2|
Hyperplasia, Lymphoid | 1 2 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Multifocal | 1 1 2 |
Necrosis, Multifocal | 2 |
Pigmentation | |
Centrilobular, Necrosis | |
Hepatocyte, Cytomegaly | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + |
Atrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + A + + |
__________________________________________________________________________|
Stomach | + + + + + + + A + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + |
Erosion | 2 |
__________________________________________________________________________|
Tooth | + + + |
Incisor, Dysplasia | 2 3 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + A + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + A + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + A + + |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + A + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 7| 6| 6| 7| 7| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 4| 7| 5| 3| 0| 3| 2| 5| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 3| 3|
| 1| 1| 1| 1| 4| 1| 8| 4| 1| 1| 2| 7| 4| 2| 2| 8| 2| 5| 2| 2| 9| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + A + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + A + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Degeneration, Cystic | 2 1 1 2 1|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + A + + |
__________________________________________________________________________|
Penis | + |
Fibrosis | 4 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + |
Degeneration, Cystic | 2 3 |
Inflammation, Suppurative | 2 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + A M + |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + A + + |
Dilatation | 3 |
Inflammation, Chronic | 3 3 4 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Testes | + + + + + + + A + + + |
Mineralization | |
Germinal Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + A + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + A + + + + |
Inguinal, Hyperplasia | 2 |
Mesenteric, Angiectasis | 2 2 1 2 2 2 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M M + A + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Depletion Cellular | 3 2 |
Hematopoietic Cell Proliferation | 2 3 3 2 3 2 2 2 3 3|
__________________________________________________________________________|
Thymus | + + + + + + + A + + |
Cyst | |
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 7| 6| 6| 7| 7| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 4| 7| 5| 3| 0| 3| 2| 5| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 3| 3|
| 1| 1| 1| 1| 4| 1| 8| 4| 1| 1| 2| 7| 4| 2| 2| 8| 2| 5| 2| 2| 9| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + M M M + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + A + + + + + + +|
Exudate | |
Inflammation, Chronic | 1 2 2 2 2 1 2 2 2 1 3|
Metaplasia, Osseous | 3 |
Ulcer | 3|
Hair Follicle, Atrophy | |
Prepuce, Foreign Body | |
Prepuce, Inflammation, Chronic | |
Prepuce, Ulcer | 4 |
Subcutaneous Tissue, Edema | 2 |
Subcutaneous Tissue, Fibrosis | 3 |
Subcutaneous Tissue, Foreign Body | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + A + + |
Distal, Joint, Femur, Arthrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + A + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + A + + |
Congestion | |
Edema | |
Infiltration Cellular, Mixed Cell | 2 |
Interstitium, Inflammation | |
__________________________________________________________________________|
Nose | + + + + + + + A + + |
Lumen, Exudate | |
Lumen, Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + A + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +|
Angiectasis | |
Inflammation, Suppurative | |
Metaplasia, Osseous | 2 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 3 2 1 1 3 1|
Papilla, Necrosis | |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 5| 6| 7| 6| 7| 6| 6| 7| 7| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 4| 7| 5| 3| 0| 3| 2| 5| 3| 3| 9| 3| 7| 3| 3| 0| 3| 3| 3| 3|
| 1| 1| 1| 1| 4| 1| 8| 4| 1| 1| 2| 7| 4| 2| 2| 8| 2| 5| 2| 2| 9| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Degeneration, Hyaline | 2 |
Renal Tubule, Dilatation | |
Renal Tubule, Mineralization | |
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 2 2 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 1 1 2 2 1 2|
Renal Tubule, Epithelium, Necrosis | |
__________________________________________________________________________|
Urethra | + + |
Fibrosis | 2 |
Inflammation, Suppurative | |
Bulbourethral Gland, Dilatation | 3 3 |
Bulbourethral Gland, Fibrosis | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | 1 1 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 9| 9| 2| 6| 0| 3| 3| 3| 3| 9| 3| 9| 3| 1| 8| 3| 3| 3|
| 9| 5| 5| 5| 5| 5| 5| 7| 7| 4| 7| 1| 5| 5| 5| 5| 3| 5| 9| 5| 4| 2| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + |
Prolapse | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + |
Perforation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Fatty Change | 1 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 |
Inflammation, Multifocal | 1 1 2 1 1 2 1 1|
Necrosis, Multifocal | 1 2 2 1 1|
Pigmentation | 2 |
Centrilobular, Necrosis | 1 |
Hepatocyte, Cytomegaly | 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + |
Atrophy, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + |
Erosion | |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 9| 9| 2| 6| 0| 3| 3| 3| 3| 9| 3| 9| 3| 1| 8| 3| 3| 3|
| 9| 5| 5| 5| 5| 5| 5| 7| 7| 4| 7| 1| 5| 5| 5| 5| 3| 5| 9| 5| 4| 2| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 2 1 1 1|
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | 2 1 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + |
__________________________________________________________________________|
Penis | |
Fibrosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + |
Degeneration, Cystic | 3 |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + |
Dilatation | 3 |
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + |
Mineralization | 2 |
Germinal Epithelium, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | |
Mesenteric, Angiectasis | 2 2 2 2 2 1 2 2 1|
Mesenteric, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Hematopoietic Cell Proliferation | 3 2 2 3 3 3 2 2 3 3 4 4 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + |
Cyst | 1 |
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 9| 9| 2| 6| 0| 3| 3| 3| 3| 9| 3| 9| 3| 1| 8| 3| 3| 3|
| 9| 5| 5| 5| 5| 5| 5| 7| 7| 4| 7| 1| 5| 5| 5| 5| 3| 5| 9| 5| 4| 2| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M M + M M + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + M + + + + + + + + +|
Exudate | 2 |
Inflammation, Chronic | 2 1 1 2 3 1 2 1 2 2 3 3|
Metaplasia, Osseous | |
Ulcer | 3 3 3 |
Hair Follicle, Atrophy | 2 |
Prepuce, Foreign Body | 2 |
Prepuce, Inflammation, Chronic | 2 |
Prepuce, Ulcer | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Foreign Body | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
Distal, Joint, Femur, Arthrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + |
Congestion | |
Edema | |
Infiltration Cellular, Mixed Cell | 2 |
Interstitium, Inflammation | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
Lumen, Exudate | 2 2 |
Lumen, Foreign Body | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation, Suppurative | |
Metaplasia, Osseous | |
Nephropathy | 1 1 2 1 2 1 1 2 2 2 3 1 1 1 2 1 1 2 1 2 1 1 1|
Papilla, Necrosis | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 9| 9| 2| 6| 0| 3| 3| 3| 3| 9| 3| 9| 3| 1| 8| 3| 3| 3|
| 9| 5| 5| 5| 5| 5| 5| 7| 7| 4| 7| 1| 5| 5| 5| 5| 3| 5| 9| 5| 4| 2| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.625% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Dilatation | |
Renal Tubule, Mineralization | |
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 1 1 2 2 2 2 2 1 2 1 2 2 1 2 2 2 2 2 2 2 2 2 2|
Renal Tubule, Epithelium, Necrosis | 1 |
__________________________________________________________________________|
Urethra | + |
Fibrosis | |
Inflammation, Suppurative | 2 |
Bulbourethral Gland, Dilatation | |
Bulbourethral Gland, Fibrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 2 |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 3| 3| 4| 4| 4| | |
DAY ON TEST | 3| 6| 6| 6| 3| 4| 9| 6| 6| 6| | |
| 5| 3| 3| 3| 5| 6| 4| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 21 |
__________________________________________________________________________|____________|
Gallbladder | A + | 19 |
__________________________________________________________________________|____________|
Intestine Large | A + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + | 19 |
Prolapse | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | A + | 21 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A M | 17 |
Perforation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + | 18 |
__________________________________________________________________________|____________|
Liver | + + + + | 53 |
Basophilic Focus | 3 | 2 3.0|
Fatty Change | 1 | 2 1.0|
Hematopoietic Cell Proliferation | 2 | 3 1.7|
Hyperplasia, Lymphoid | | 3 1.7|
Infiltration Cellular, Mixed Cell | | 5 2.0|
Inflammation, Multifocal | | 11 1.3|
Necrosis, Multifocal | | 6 1.5|
Pigmentation | | 1 2.0|
Centrilobular, Necrosis | | 1 1.0|
Hepatocyte, Cytomegaly | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Inflammation, Chronic | 3 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + | 23 |
Atrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 21 |
__________________________________________________________________________|____________|
Stomach | + + | 21 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 20 |
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 4 |
Incisor, Dysplasia | | 4 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 21 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 3| 3| 4| 4| 4| | |
DAY ON TEST | 3| 6| 6| 6| 3| 4| 9| 6| 6| 6| | |
| 5| 3| 3| 3| 5| 6| 4| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 22 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 20 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 21 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 21 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 21 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 53 |
Degeneration, Cystic | 2 | 13 1.3|
Follicle, Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | | 8 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 21 |
__________________________________________________________________________|____________|
Penis | | 1 |
Fibrosis | | 1 4.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | | 6 |
Degeneration, Cystic | | 3 2.7|
Inflammation, Suppurative | | 5 3.0|
__________________________________________________________________________|____________|
Prostate | + + | 20 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 23 |
Dilatation | 3 | 3 3.0|
Inflammation, Chronic | | 3 3.3|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + | 22 |
Mineralization | | 1 2.0|
Germinal Epithelium, Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + | 21 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 33 |
Inguinal, Hyperplasia | | 1 2.0|
Mesenteric, Angiectasis | 2 | 17 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 3| 3| 4| 4| 4| | |
DAY ON TEST | 3| 6| 6| 6| 3| 4| 9| 6| 6| 6| | |
| 5| 3| 3| 3| 5| 6| 4| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mesenteric, Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 19 |
__________________________________________________________________________|____________|
Spleen | + + + + | 53 |
Depletion Cellular | | 3 2.3|
Hematopoietic Cell Proliferation | 2 3 | 25 2.6|
__________________________________________________________________________|____________|
Thymus | M + | 19 |
Cyst | | 1 1.0|
Depletion Lymphoid | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | 9 |
__________________________________________________________________________|____________|
Skin | + + + | 45 |
Exudate | | 1 2.0|
Inflammation, Chronic | 3 | 24 1.9|
Metaplasia, Osseous | | 1 3.0|
Ulcer | 4 | 5 3.2|
Hair Follicle, Atrophy | | 1 2.0|
Prepuce, Foreign Body | | 1 2.0|
Prepuce, Inflammation, Chronic | | 1 2.0|
Prepuce, Ulcer | | 1 4.0|
Subcutaneous Tissue, Edema | | 1 2.0|
Subcutaneous Tissue, Fibrosis | | 1 3.0|
Subcutaneous Tissue, Foreign Body | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 21 |
Distal, Joint, Femur, Arthrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 21 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 25 |
Congestion | 2 2 | 2 2.0|
Edema | 1 | 1 1.0|
Infiltration Cellular, Mixed Cell | | 2 2.0|
Interstitium, Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + | 21 |
Lumen, Exudate | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05025-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYLENE GLYCOL Date: 04/28/97
Route: DOSED FEED Time: 09:01:29
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 4| 7| 3| 3| 4| 4| 4| | |
DAY ON TEST | 3| 6| 6| 6| 3| 4| 9| 6| 6| 6| | |
| 5| 3| 3| 3| 5| 6| 4| 3| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.625% | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lumen, Foreign Body | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + | 21 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 53 |
Angiectasis | 1 | 1 1.0|
Inflammation, Suppurative | 4 | 1 4.0|
Metaplasia, Osseous | | 1 2.0|
Nephropathy | 1 1 | 44 1.3|
Papilla, Necrosis | 4 | 1 4.0|
Renal Tubule, Degeneration, Hyaline | | 1 2.0|
Renal Tubule, Dilatation | 2 2 | 2 2.0|
Renal Tubule, Mineralization | 2 | 1 2.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 2 2 | 50 1.7|
Renal Tubule, Epithelium, Necrosis | 1 | 2 1.0|
__________________________________________________________________________|____________|
Urethra | + | 4 |
Fibrosis | | 1 2.0|
Inflammation, Suppurative | 3 | 2 2.5|
Bulbourethral Gland, Dilatation | | 2 3.0|
Bulbourethral Gland, Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 53 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | 3 | 4 1.8|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
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