TDMS Study 05028-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
HEXACHLOROETHANE
NTP Experiment-Test: 05028-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/04/94
Route: GAVAGE Time: 09:34:50
Facility: TSI Mason Research
Chemical CAS #: 67-72-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .08G/KG .16G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 4 2 3
Moribund 14 20 15
Accident 1
Survivors
Terminal Sacrifice 32 27 32
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (48) (10) (47)
Intestine Small, Jejunum (50) (10) (48)
Liver (50) (32) (50)
Carcinoma, Metastatic, Adrenal Gland 1 (3%)
Hepatocellular Carcinoma 1 (3%)
Neoplastic Nodule 1 (2%) 2 (6%) 1 (2%)
Mesentery (7) (5) (5)
Pancreas (48) (12) (49)
Pharynx (1)
Palate, Squamous Cell Papilloma 1 (100%)
Stomach, Forestomach (50) (12) (50)
Stomach, Glandular (49) (10) (50)
Sarcoma 1 (2%)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (11) (50)
Schwannoma Malignant 1 (2%)
Ventricle Left, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (15) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (7%)
Adrenal Gland, Medulla (50) (15) (46)
Pheochromocytoma Malignant 1 (7%)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Page 2
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .08G/KG .16G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Bilateral, Pheochromocytoma Benign 1 (7%) 1 (2%)
Islets, Pancreatic (49) (11) (49)
Carcinoma 1 (9%)
Parathyroid Gland (38) (40) (38)
Adenoma 1 (3%)
Pituitary Gland (50) (49) (49)
Pars Distalis, Adenoma 26 (52%) 20 (41%) 16 (33%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (50) (50) (50)
C-Cell, Adenoma 9 (18%) 7 (14%) 6 (12%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (46) (10) (39)
Adenoma 3 (7%) 2 (5%)
Carcinoma 1 (2%) 1 (10%)
Ovary (50) (14) (50)
Cystadenoma 1 (2%)
Uterus (48) (25) (50)
Leiomyoma 1 (2%)
Polyp Stromal 10 (21%) 7 (28%) 5 (10%)
Cervix, Endometrium, Sarcoma Stromal 1 (2%)
Endometrium, Adenocarcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (11) (49)
Lymph Node (49) (17) (50)
Carcinosarcoma, Metastatic, Zymbal's Gland 1 (2%)
Lymph Node, Mandibular (46) (10) (43)
Lymph Node, Mesenteric (48) (12) (49)
Spleen (50) (23) (50)
Thymus (41) (11) (45)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .08G/KG .16G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (28) (46)
Adenocarcinoma 1 (4%)
Fibroadenoma 17 (35%) 17 (61%) 20 (43%)
Fibroadenoma, Multiple 11 (23%) 4 (14%) 4 (9%)
Skin (49) (12) (48)
Keratoacanthoma 1 (8%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 2 (17%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50)
Astrocytoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (29) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Adrenal Gland 1 (3%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Nose (49) (9) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (6) (6) (6)
Conjunctiva, Squamous Cell Carcinoma 1 (17%)
Harderian Gland (3) (1)
Adenocarcinoma 1 (100%)
Zymbal's Gland (2)
Carcinoma 2 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .08G/KG .16G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Urinary Bladder (46) (11) (47)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Monocytic 1 (2%)
Leukemia Mononuclear 19 (38%) 12 (24%) 15 (30%)
Lymphoma Malignant Lymphocytic 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .08G/KG .16G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 44 43
Total Primary Neoplasms 114 82 87
Total Animals with Benign Neoplasms 44 36 40
Total Benign Neoplasms 86 63 61
Total Animals with Malignant Neoplasms 22 16 20
Total Malignant Neoplasms 28 19 26
Total Animals with Metastatic Neoplasms 1 1 1
Total Metastatic Neoplasm 1 2 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .01G/KG .02G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 16 14 19
Accident 1 1
Dead 2 6 4
Gavage Death 1
Survivors
Terminal Sacrifice 31 29 26
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (13) (46)
Intestine Small, Duodenum (50) (15) (50)
Adenocarcinoma 1 (2%)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (49) (14) (47)
Leiomyosarcoma 1 (7%)
Liver (50) (31) (50)
Fibrosarcoma, Metastatic, Skin 1 (3%)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Neoplastic Nodule 1 (2%) 1 (3%) 1 (2%)
Mesentery (1) (5) (5)
Sarcoma 1 (20%)
Pancreas (50) (18) (50)
Adenoma 1 (6%)
Acinus, Adenoma 3 (17%)
Pharynx (1) (1)
Palate, Squamous Cell Papilloma 1 (100%) 1 (100%)
Stomach, Forestomach (48) (18) (49)
Squamous Cell Papilloma 1 (6%)
Stomach, Glandular (50) (19) (49)
Tongue (2) (1)
Squamous Cell Papilloma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (15) (50)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .01G/KG .02G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Adrenal Gland, Medulla (50) (45) (49)
Pheochromocytoma Malignant 1 (2%) 2 (4%) 1 (2%)
Pheochromocytoma Complex 2 (4%)
Pheochromocytoma Benign 11 (22%) 19 (42%) 15 (31%)
Bilateral, Pheochromocytoma Benign 3 (6%) 7 (16%) 4 (8%)
Islets, Pancreatic (50) (17) (50)
Adenoma 2 (4%) 2 (12%)
Carcinoma 2 (4%)
Parathyroid Gland (41) (40) (43)
Adenoma 1 (3%) 1 (2%)
Pituitary Gland (49) (50) (48)
Pars Distalis, Adenoma 24 (49%) 22 (44%) 16 (33%)
Thyroid Gland (49) (50) (50)
C-Cell, Adenoma 6 (12%) 9 (18%) 5 (10%)
C-Cell, Carcinoma 3 (6%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (14) (50)
Preputial Gland (46) (17) (49)
Adenoma 1 (2%) 2 (12%) 2 (4%)
Carcinoma 1 (6%) 1 (2%)
Bilateral, Adenoma 1 (2%)
Prostate (50) (13) (48)
Testes (49) (46) (50)
Bilateral, Interstitial Cell, Adenoma 32 (65%) 36 (78%) 42 (84%)
Interstitial Cell, Adenoma 11 (22%) 5 (11%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (13) (49)
Lymph Node (50) (31) (50)
Lymph Node, Mandibular (45) (23) (44)
Lymph Node, Mesenteric (50) (15) (48)
Spleen (49) (28) (50)
Thymus (47) (11) (43)
Page 8
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .01G/KG .02G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymoma Benign 2 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (33) (16) (23)
Adenocarcinoma 1 (3%) 1 (4%)
Fibroadenoma 6 (18%) 6 (38%) 1 (4%)
Fibroadenoma, Multiple 1 (3%)
Lipoma 1 (6%)
Skin (48) (21) (50)
Basal Cell Adenoma 1 (5%)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 6 (13%) 5 (24%) 5 (10%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (5%)
Trichoepithelioma 1 (5%)
Subcutaneous Tissue, Fibroma 6 (13%) 3 (14%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 3 (14%) 2 (4%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (13) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (4) (2) (2)
Lipoma 1 (25%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (13) (50)
Astrocytoma Malignant 1 (2%)
Cranial Nerve, Schwannoma Malignant 1 (2%)
Spinal Cord (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (24) (50)
Alveolar/Bronchiolar Adenoma 4 (8%) 2 (4%)
Carcinoma, Metastatic, Kidney 1 (2%)
Nose (50) (13) (50)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .01G/KG .02G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2)
Adenoma 1 (50%)
Zymbal's Gland (2)
Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Adenoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 2 (4%) 3 (6%)
Renal Tubule, Carcinoma 3 (6%)
Urinary Bladder (47) (10) (46)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 13 (26%) 15 (30%) 11 (22%)
Mesothelioma Malignant 2 (4%)
Mesothelioma NOS 1 (2%) 1 (2%) 5 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05028-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROETHANE Date: 09/04/94
Route: GAVAGE Time: 09:34:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .01G/KG .02G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 49 48
Total Primary Neoplasms 149 161 141
Total Animals with Benign Neoplasms 48 49 48
Total Benign Neoplasms 118 134 107
Total Animals with Malignant Neoplasms 24 22 22
Total Malignant Neoplasms 30 26 29
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1 5
Total Uncertain Neoplasms 6 6 20
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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