TDMS Study 05028-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason HEXACHLOROETHANE DATE: 09/04/94
EXPERIMENT: 05028 TEST: 01 TIME: 09:45:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01CP9561904 ROUTE: GAVAGE NTP C#: 04604B
PATHOLOGIST: A. RUSSFIELD CAS: 67-72-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason HEXACHLOROETHANE DATE: 09/04/94
EXPERIMENT: 05028 TEST: 01 TIME: 09:45:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561904 ROUTE: GAVAGE NTP C#: 04604B
PATHOLOGIST: A. RUSSFIELD CAS: 67-72-1
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason HEXACHLOROETHANE DATE: 09/04/94
EXPERIMENT: 05028 TEST: 01 TIME: 09:45:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561904 ROUTE: GAVAGE NTP C#: 04604B
PATHOLOGIST: A. RUSSFIELD CAS: 67-72-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF HEXACHLOROETHANE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Kidney: Renal Tubule Carcinoma
Carcinoma or Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pancreas Adenoma
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma: Benign, Complex, Malignant, NOS
Liver Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/50 (28%) 26/45 (58%) 19/49 (39%) | 1/50 (2%) 1/15 (7%) 2/46 (4%) |
|ADJUSTED (b) | 37.8% 76.1% 56.3% | 3.1% 33.3% 6.3% |
|TERMINAL (d) | 9/31 (29%) 20/28 (71%) 12/26 (46%) | 1/32 (3%) 1/3 (33%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 637 578 577 | 731 (T) 731 (T) 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.064 P=0.006 ** P=0.091 | P=0.378 P=0.200 P=0.489 |
|INCIDENTAL TUMOR | P=0.091 P=0.002 ** P=0.154 | P=0.338 P=0.200 P=0.431 |
|LOGISTIC REGRESSION | P=0.089 P=0.002 ** P=0.133 | P=0.377 P=0.200 P=0.481 |
|COCHRAN-ARMITAGE | P=0.158 | P=0.362 |
|FISHER EXACT | P=0.003 ** P=0.178 | P=0.411 P=0.468 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Complex |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/45 (0%) 2/49 (4%) | 0/50 (0%) 0/15 (0%) 0/46 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 7.2% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/28 (0%) 1/26 (4%) | 0/32 (0%) 0/3 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 703 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.080 (e) P=0.204 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.088 (e) P=0.208 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.085 (e) P=0.212 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.097 | (e) |
|FISHER EXACT | (e) P=0.242 | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/45 (4%) 1/49 (2%) | 0/50 (0%) 1/15 (7%) 0/46 (0%) |
|ADJUSTED (b) | 3.2% 7.1% 3.8% | 0.0% 2.8% 0.0% |
|TERMINAL (d) | 1/31 (3%) 2/28 (7%) 1/26 (4%) | 0/32 (0%) 0/3 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) 733 (T) | --- 660 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.566 P=0.464 P=0.723 | P=0.718 P=0.484 (e) |
|INCIDENTAL TUMOR | P=0.566 P=0.464 P=0.723 | P=0.629 P=0.227 (e) |
|LOGISTIC REGRESSION | P=0.566 P=0.464 P=0.723 | P=0.704 P=0.280 (e) |
|COCHRAN-ARMITAGE | P=0.614 | P=0.692 |
|FISHER EXACT | P=0.460 P=0.747 | P=0.231 (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/50 (30%) 28/45 (62%) 21/49 (43%) | 1/50 (2%) 2/15 (13%) 2/46 (4%) |
|ADJUSTED (b) | 40.7% 82.1% 62.5% | 3.1% 35.2% 6.3% |
|TERMINAL (d) | 10/31 (32%) 22/28 (79%) 14/26 (54%) | 1/32 (3%) 1/3 (33%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 637 578 577 | 731 (T) 660 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.038 * P=0.003 ** P=0.058 | P=0.383 P=0.090 P=0.489 |
|INCIDENTAL TUMOR | P=0.053 P<0.001 ** P=0.101 | P=0.316 P=0.022 * P=0.431 |
|LOGISTIC REGRESSION | P=0.051 P<0.001 ** P=0.086 | P=0.367 P=0.028 * P=0.481 |
|COCHRAN-ARMITAGE | P=0.115 | P=0.369 |
|FISHER EXACT | P=0.002 ** P=0.131 | P=0.131 P=0.468 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/46 (2%) 2/17 (12%) 3/49 (6%) | 3/46 (7%) 0/10 (0%) 2/39 (5%) |
|ADJUSTED (b) | 3.3% 35.4% 10.4% | 10.3% 0.0% 6.7% |
|TERMINAL (d) | 1/30 (3%) 1/3 (33%) 2/25 (8%) | 3/29 (10%) 0/2 (0%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 708 630 | 731 (T) --- 715 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.189 P=0.097 P=0.249 | P=0.443N P=0.772N P=0.537N |
|INCIDENTAL TUMOR | P=0.235 P=0.011 * P=0.300 | P=0.489N P=0.772N P=0.582N |
|LOGISTIC REGRESSION | P=0.225 P=0.015 * P=0.290 | P=0.452N P=0.772N P=0.548N |
|COCHRAN-ARMITAGE | P=0.271 | P=0.474N |
|FISHER EXACT | P=0.175 P=0.333 | P=0.548N P=0.579N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/46 (2%) 3/17 (18%) 4/49 (8%) | 4/46 (9%) 1/10 (10%) 2/39 (5%) |
|ADJUSTED (b) | 3.3% 67.7% 12.5% | 13.8% 50.0% 6.7% |
|TERMINAL (d) | 1/30 (3%) 2/3 (67%) 2/25 (8%) | 4/29 (14%) 1/2 (50%) 1/26 (4%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 708 558 | 731 (T) 731 (T) 715 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.113 P=0.006 ** P=0.141 | P=0.312N P=0.364 P=0.377N |
|INCIDENTAL TUMOR | P=0.157 P<0.001 ** P=0.205 | P=0.351N P=0.364 P=0.417N |
|LOGISTIC REGRESSION | P=0.155 P<0.001 ** P=0.195 | P=0.316N P=0.364 P=0.381N |
|COCHRAN-ARMITAGE | P=0.181 | P=0.341N |
|FISHER EXACT | P=0.057 P=0.201 | P=0.641 P=0.420N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Heart |
| Schwannoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/15 (0%) 0/50 (0%) | 2/50 (4%) 0/11 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.2% 0.0% 0.0% | 5.9% 0.0% 0.0% |
|TERMINAL (d) | 1/31 (3%) 0/2 (0%) 0/26 (0%) | 1/32 (3%) 0/0 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) --- --- | 693 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.336N P=0.967N P=0.535N | P=0.125N P=0.531N P=0.240N |
|INCIDENTAL TUMOR | P=0.336N P=0.967N P=0.535N | P=0.174N P=0.892N P=0.291N |
|LOGISTIC REGRESSION | P=0.336N P=0.967N P=0.535N | P=0.141N P=0.875N P=0.245N |
|COCHRAN-ARMITAGE | P=0.295N | P=0.130N |
|FISHER EXACT | P=0.769N P=0.500N | P=0.669N P=0.247N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/17 (12%) 0/50 (0%) | 0/49 (0%) 0/11 (0%) 0/49 (0%) |
|ADJUSTED (b) | 6.5% 34.7% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/31 (6%) 1/3 (33%) 0/26 (0%) | 0/32 (0%) 0/0 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 370 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.249N P=0.145 P=0.277N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.209N P=0.143 P=0.277N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.198N P=0.307 P=0.277N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.205N | (e) |
|FISHER EXACT | P=0.265 P=0.247N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/17 (0%) 2/50 (4%) | 0/49 (0%) 1/11 (9%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/3 (0%) 1/26 (4%) | 0/32 (0%) 0/0 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 630 | --- 660 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.101 (e) P=0.207 | P=0.718 P=0.484 (e) |
|INCIDENTAL TUMOR | P=0.127 (e) P=0.273 | P=0.642 P=0.128 (e) |
|LOGISTIC REGRESSION | P=0.121 (e) P=0.234 | P=0.698N P=0.205 (e) |
|COCHRAN-ARMITAGE | P=0.124 | P=0.702 |
|FISHER EXACT | (e) P=0.247 | P=0.183 (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/17 (12%) 2/50 (4%) | 0/49 (0%) 1/11 (9%) 0/49 (0%) |
|ADJUSTED (b) | 6.5% 34.7% 6.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/31 (6%) 1/3 (33%) 1/26 (4%) | 0/32 (0%) 0/0 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 370 630 | --- 660 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.522 P=0.145 P=0.634 | P=0.718 P=0.484 (e) |
|INCIDENTAL TUMOR | P=0.576N P=0.143 P=0.693 | P=0.642 P=0.128 (e) |
|LOGISTIC REGRESSION | P=0.587N P=0.307 P=0.668 | P=0.698N P=0.205 (e) |
|COCHRAN-ARMITAGE | P=0.590 | P=0.702 |
|FISHER EXACT | P=0.265 P=0.691N | P=0.183 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.6% 5.9% 15.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/29 (0%) 4/26 (15%) | 0/32 (0%) 0/27 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 654 677 733 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.088 P=0.497 P=0.132 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.087 P=0.457 P=0.135 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.096 P=0.500 P=0.146 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.118 | (e) |
|FISHER EXACT | P=0.500 P=0.181 | (e) (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 9.2% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/29 (0%) 1/26 (4%) | 0/32 (0%) 0/27 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 636 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.030 * (e) P=0.098 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.047 * (e) P=0.169 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.037 * (e) P=0.121 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.037 * | (e) |
|FISHER EXACT | (e) P=0.121 | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 7/50 (14%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.6% 5.9% 23.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/29 (0%) 5/26 (19%) | 0/32 (0%) 0/27 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 654 677 636 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.009 ** P=0.497 P=0.020 * | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.012 * P=0.457 P=0.033 * | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.011 * P=0.500 P=0.026 * | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.014 * | (e) |
|FISHER EXACT | P=0.500 P=0.030 * | (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/31 (3%) 1/50 (2%) | 1/50 (2%) 2/32 (6%) 1/50 (2%) |
|ADJUSTED (b) | 3.2% 7.7% 3.8% | 3.1% 18.2% 2.8% |
|TERMINAL (d) | 1/31 (3%) 1/13 (8%) 1/26 (4%) | 1/32 (3%) 2/11 (18%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) 733 (T) | 731 (T) 731 (T) 692 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.574 P=0.557 P=0.723 | P=0.608N P=0.160 P=0.757N |
|INCIDENTAL TUMOR | P=0.574 P=0.557 P=0.723 | P=0.585 P=0.160 P=0.709 |
|LOGISTIC REGRESSION | P=0.574 P=0.557 P=0.723 | P=0.605 P=0.160 P=0.755 |
|COCHRAN-ARMITAGE | P=0.631 | P=0.615 |
|FISHER EXACT | P=0.622 P=0.753N | P=0.336 P=0.753N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/31 (3%) 2/50 (4%) | 1/50 (2%) 3/32 (9%) 1/50 (2%) |
|ADJUSTED (b) | 5.5% 7.7% 7.2% | 3.1% 27.3% 2.8% |
|TERMINAL (d) | 1/31 (3%) 1/13 (8%) 1/26 (4%) | 1/32 (3%) 3/11 (27%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 630 733 (T) 703 | 731 (T) 731 (T) 692 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.540 P=0.707N P=0.635 | P=0.597N P=0.040 * P=0.757N |
|INCIDENTAL TUMOR | P=0.581 P=0.639N P=0.691N | P=0.576 P=0.040 * P=0.709 |
|LOGISTIC REGRESSION | P=0.569 P=0.700N P=0.676 | P=0.595 P=0.040 * P=0.755 |
|COCHRAN-ARMITAGE | P=0.603 | P=0.603N |
|FISHER EXACT | P=0.675N P=0.691N | P=0.162 P=0.753N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/31 (3%) 2/50 (4%) | 1/50 (2%) 3/32 (9%) 1/50 (2%) |
|ADJUSTED (b) | 5.5% 7.7% 7.2% | 3.1% 27.3% 2.8% |
|TERMINAL (d) | 1/31 (3%) 1/13 (8%) 1/26 (4%) | 1/32 (3%) 3/11 (27%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 630 733 (T) 703 | 731 (T) 731 (T) 692 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.540 P=0.707N P=0.635 | P=0.597N P=0.040 * P=0.757N |
|INCIDENTAL TUMOR | P=0.581 P=0.639N P=0.691N | P=0.576 P=0.040 * P=0.709 |
|LOGISTIC REGRESSION | P=0.569 P=0.700N P=0.676 | P=0.595 P=0.040 * P=0.755 |
|COCHRAN-ARMITAGE | P=0.603 | P=0.603N |
|FISHER EXACT | P=0.675N P=0.691N | P=0.162 P=0.753N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 0/24 (0%) 2/50 (4%) | 2/50 (4%) 0/29 (0%) 1/50 (2%) |
|ADJUSTED (b) | 11.5% 0.0% 6.5% | 6.3% 0.0% 3.0% |
|TERMINAL (d) | 2/31 (6%) 0/6 (0%) 1/26 (4%) | 2/32 (6%) 0/13 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 646 --- 636 | 731 (T) --- 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.307N P=0.185N P=0.424N | P=0.369N P=0.451N P=0.496N |
|INCIDENTAL TUMOR | P=0.270N P=0.258N P=0.358N | P=0.411N P=0.451N P=0.554N |
|LOGISTIC REGRESSION | P=0.271N P=0.257N P=0.361N | P=0.371N P=0.451N P=0.497N |
|COCHRAN-ARMITAGE | P=0.242N | P=0.370N |
|FISHER EXACT | P=0.200N P=0.339N | P=0.398N P=0.500N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 0/24 (0%) 2/50 (4%) | 2/50 (4%) 0/29 (0%) 2/50 (4%) |
|ADJUSTED (b) | 11.5% 0.0% 6.5% | 6.3% 0.0% 6.1% |
|TERMINAL (d) | 2/31 (6%) 0/6 (0%) 1/26 (4%) | 2/32 (6%) 0/13 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 646 --- 636 | 731 (T) --- 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.307N P=0.185N P=0.424N | P=0.609N P=0.451N P=0.691N |
|INCIDENTAL TUMOR | P=0.270N P=0.258N P=0.358N | P=0.577 P=0.451N P=0.652 |
|LOGISTIC REGRESSION | P=0.271N P=0.257N P=0.361N | P=0.607N P=0.451N P=0.693N |
|COCHRAN-ARMITAGE | P=0.242N | P=0.613N |
|FISHER EXACT | P=0.200N P=0.339N | P=0.398N P=0.691N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 6/50 (12%) 1/50 (2%) | 28/50 (56%) 21/50 (42%) 24/50 (48%) |
|ADJUSTED (b) | 20.6% 19.0% 3.8% | 67.8% 55.1% 60.6% |
|TERMINAL (d) | 5/31 (16%) 4/29 (14%) 1/26 (4%) | 19/32 (59%) 11/27 (41%) 17/32 (53%) |
|FIRST INCIDENCE (DAYS) | 630 684 733 (T) | 552 503 450 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.053N P=0.550N P=0.057N | P=0.293N P=0.321N P=0.316N |
|INCIDENTAL TUMOR | P=0.043N* P=0.527N P=0.043N* | P=0.255N P=0.117N P=0.302N |
|LOGISTIC REGRESSION | P=0.042N* P=0.519N P=0.045N* | P=0.269N P=0.133N P=0.312N |
|COCHRAN-ARMITAGE | P=0.029N* | P=0.242N |
|FISHER EXACT | P=0.500N P=0.030N* | P=0.115N P=0.274N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 6/50 (12%) 2/50 (4%) | 28/50 (56%) 21/50 (42%) 24/50 (48%) |
|ADJUSTED (b) | 23.7% 19.0% 7.7% | 67.8% 55.1% 60.6% |
|TERMINAL (d) | 6/31 (19%) 4/29 (14%) 2/26 (8%) | 19/32 (59%) 11/27 (41%) 17/32 (53%) |
|FIRST INCIDENCE (DAYS) | 630 684 733 (T) | 552 503 450 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.068N P=0.439N P=0.083N | P=0.293N P=0.321N P=0.316N |
|INCIDENTAL TUMOR | P=0.057N P=0.415N P=0.066N | P=0.255N P=0.117N P=0.302N |
|LOGISTIC REGRESSION | P=0.055N P=0.405N P=0.069N | P=0.269N P=0.133N P=0.312N |
|COCHRAN-ARMITAGE | P=0.037N* | P=0.242N |
|FISHER EXACT | P=0.387N P=0.046N* | P=0.115N P=0.274N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 6.9% 2.9% | 0.0% 3.7% 2.5% |
|TERMINAL (d) | 0/31 (0%) 2/29 (7%) 0/26 (0%) | 0/32 (0%) 1/27 (4%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 649 | --- 731 (T) 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.321 P=0.223 P=0.478 | P=0.332 P=0.466 P=0.495 |
|INCIDENTAL TUMOR | P=0.321 P=0.223 P=0.477 | P=0.336 P=0.466 P=0.500 |
|LOGISTIC REGRESSION | P=0.341 P=0.223 P=0.504 | P=0.335 P=0.466 P=0.553 |
|COCHRAN-ARMITAGE | P=0.360 | P=0.331 |
|FISHER EXACT | P=0.247 P=0.500 | P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 6.9% 2.9% | 0.0% 3.7% 2.5% |
|TERMINAL (d) | 0/31 (0%) 2/29 (7%) 0/26 (0%) | 0/32 (0%) 1/27 (4%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- 733 (T) 649 | --- 731 (T) 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.321 P=0.223 P=0.478 | P=0.332 P=0.466 P=0.495 |
|INCIDENTAL TUMOR | P=0.321 P=0.223 P=0.477 | P=0.336 P=0.466 P=0.500 |
|LOGISTIC REGRESSION | P=0.341 P=0.223 P=0.504 | P=0.335 P=0.466 P=0.553 |
|COCHRAN-ARMITAGE | P=0.360 | P=0.331 |
|FISHER EXACT | P=0.247 P=0.500 | P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 4/18 (22%) 0/50 (0%) | 0/48 (0%) 0/12 (0%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 75.6% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 3/4 (75%) 0/26 (0%) | 0/32 (0%) 0/0 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- 617 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.546 P<0.001 ** (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.590 P<0.001 ** (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.577 P<0.001 ** (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.609 | (e) |
|FISHER EXACT | P=0.004 ** (e) | (e) (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/49 (49%) 22/50 (44%) 16/48 (33%) | 26/50 (52%) 20/49 (41%) 16/49 (33%) |
|ADJUSTED (b) | 62.5% 55.3% 49.4% | 63.0% 55.7% 43.4% |
|TERMINAL (d) | 17/31 (55%) 12/29 (41%) 10/25 (40%) | 17/32 (53%) 12/27 (44%) 12/32 (38%) |
|FIRST INCIDENCE (DAYS) | 568 559 472 | 506 616 575 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.243N P=0.517N P=0.265N | P=0.047N* P=0.373N P=0.051N |
|INCIDENTAL TUMOR | P=0.095N P=0.403N P=0.121N | P=0.043N* P=0.143N P=0.054N |
|LOGISTIC REGRESSION | P=0.099N P=0.405N P=0.121N | P=0.036N* P=0.214N P=0.046N* |
|COCHRAN-ARMITAGE | P=0.073N | P=0.032N* |
|FISHER EXACT | P=0.384N P=0.087N | P=0.180N P=0.040N* |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/49 (49%) 22/50 (44%) 16/48 (33%) | 26/50 (52%) 20/49 (41%) 17/49 (35%) |
|ADJUSTED (b) | 62.5% 55.3% 49.4% | 63.0% 55.7% 45.0% |
|TERMINAL (d) | 17/31 (55%) 12/29 (41%) 10/25 (40%) | 17/32 (53%) 12/27 (44%) 12/32 (38%) |
|FIRST INCIDENCE (DAYS) | 568 559 472 | 506 616 575 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.243N P=0.517N P=0.265N | P=0.069N P=0.373N P=0.077N |
|INCIDENTAL TUMOR | P=0.095N P=0.403N P=0.121N | P=0.069N P=0.143N P=0.086N |
|LOGISTIC REGRESSION | P=0.099N P=0.405N P=0.121N | P=0.057N P=0.214N P=0.070N |
|COCHRAN-ARMITAGE | P=0.073N | P=0.050N |
|FISHER EXACT | P=0.384N P=0.087N | P=0.180N P=0.062N |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 5/50 (10%) 5/50 (10%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 18.3% 15.1% 17.5% | 0.0% 2.1% 0.0% |
|TERMINAL (d) | 5/31 (16%) 3/29 (10%) 4/26 (15%) | 0/32 (0%) 0/27 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 654 559 587 | --- 548 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.548N P=0.536N P=0.617N | P=0.722 P=0.496 (e) |
|INCIDENTAL TUMOR | P=0.496N P=0.517N P=0.577N | P=0.726 P=0.477 (e) |
|LOGISTIC REGRESSION | P=0.487N P=0.506N P=0.567N | P=0.641N P=0.652 (e) |
|COCHRAN-ARMITAGE | P=0.436N | P=0.731 |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.6% 2.3% 2.4% | 3.1% 0.0% 0.0% |
|TERMINAL (d) | 1/31 (3%) 0/29 (0%) 0/26 (0%) | 1/32 (3%) 0/27 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 646 614 586 | 731 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.421N P=0.517N P=0.547N | P=0.276N P=0.534N P=0.500N |
|INCIDENTAL TUMOR | P=0.326N P=0.463N P=0.476N | P=0.276N P=0.534N P=0.500N |
|LOGISTIC REGRESSION | P=0.372N P=0.503N P=0.494N | P=0.276N P=0.534N P=0.500N |
|COCHRAN-ARMITAGE | P=0.378N | P=0.269N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.2% 6.9% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/31 (3%) 2/29 (7%) 0/26 (0%) | 0/32 (0%) 0/27 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 733 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.407N P=0.477 P=0.535N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.407N P=0.477 P=0.535N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.407N P=0.477 P=0.535N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.360N | (e) |
|FISHER EXACT | P=0.500 P=0.500N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 8/50 (16%) 6/50 (12%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 26.5% 23.4% 19.5% | 3.1% 2.1% 0.0% |
|TERMINAL (d) | 7/31 (23%) 5/29 (17%) 4/26 (15%) | 1/32 (3%) 0/27 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 646 559 586 | 731 (T) 548 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.363N P=0.547N P=0.414N | P=0.341N P=0.739 P=0.500N |
|INCIDENTAL TUMOR | P=0.281N P=0.508N P=0.345N | P=0.336N P=0.728 P=0.500N |
|LOGISTIC REGRESSION | P=0.277N P=0.504N P=0.331N | P=0.286N P=0.726N P=0.500N |
|COCHRAN-ARMITAGE | P=0.244N | P=0.331N |
|FISHER EXACT | P=0.500N P=0.288N | P=0.753N P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 3/50 (6%) 2/50 (4%) | 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 17.2% 8.3% 7.4% | 2.3% 5.9% 3.1% |
|TERMINAL (d) | 4/31 (13%) 1/29 (3%) 1/26 (4%) | 0/32 (0%) 1/27 (4%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 568 617 724 | 623 612 731 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.134N P=0.269N P=0.195N | P=0.614 P=0.478 P=0.758 |
|INCIDENTAL TUMOR | P=0.099N P=0.221N P=0.161N | P=0.619N P=0.452 P=0.760 |
|LOGISTIC REGRESSION | P=0.097N P=0.242N P=0.154N | P=0.610N P=0.543 P=0.756N |
|COCHRAN-ARMITAGE | P=0.090N | P=0.622N |
|FISHER EXACT | P=0.243N P=0.134N | P=0.500 P=0.753N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.6% 7.4% 7.2% | 0.0% 0.0% 2.5% |
|TERMINAL (d) | 1/31 (3%) 1/29 (3%) 1/26 (4%) | 0/32 (0%) 0/27 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 646 370 703 | --- --- 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.535 P=0.485 P=0.631 | P=0.266 (e) P=0.495 |
|INCIDENTAL TUMOR | P=0.566N P=0.522 P=0.641 | P=0.274 (e) P=0.500 |
|LOGISTIC REGRESSION | P=0.583N P=0.466 P=0.672 | P=0.295 (e) P=0.553 |
|COCHRAN-ARMITAGE | P=0.594 | P=0.269 |
|FISHER EXACT | P=0.500 P=0.691N | (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 6/50 (12%) 4/50 (8%) | 1/50 (2%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 22.2% 15.3% 14.2% | 2.3% 5.9% 5.5% |
|TERMINAL (d) | 5/31 (16%) 2/29 (7%) 2/26 (8%) | 0/32 (0%) 1/27 (4%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | 568 370 703 | 623 612 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.217N P=0.421N P=0.271N | P=0.386 P=0.478 P=0.494 |
|INCIDENTAL TUMOR | P=0.141N P=0.351N P=0.228N | P=0.392 P=0.452 P=0.500 |
|LOGISTIC REGRESSION | P=0.139N P=0.395N P=0.208N | P=0.416 P=0.543 P=0.535 |
|COCHRAN-ARMITAGE | P=0.141N | P=0.390 |
|FISHER EXACT | P=0.387N P=0.178N | P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 43/49 (88%) 41/46 (89%) 45/50 (90%) | |
|ADJUSTED (b) | 93.4% 100.0% 97.8% | |
|TERMINAL (d) | 28/31 (90%) 27/27 (100%) 25/26 (96%) | |
|FIRST INCIDENCE (DAYS) | 406 489 467 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.085 P=0.416 P=0.111 | |
|INCIDENTAL TUMOR | P=0.221 P=0.543 P=0.341 | |
|LOGISTIC REGRESSION | P=0.250 P=0.506 P=0.362 | |
|COCHRAN-ARMITAGE | P=0.422 | |
|FISHER EXACT | P=0.545 P=0.486 | |
|=================================================================================================================================|
| |
|Thymus |
| Thymoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 0/11 (0%) 2/43 (5%) | 0/41 (0%) 0/11 (0%) 0/45 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 8.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/29 (0%) 0/0 2/23 (9%) | 0/24 (0%) 0/0 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 733 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.107 (e) P=0.188 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.107 (e) P=0.188 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.107 (e) P=0.188 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.116 | (e) |
|FISHER EXACT | (e) P=0.225 | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/49 (12%) 9/50 (18%) 5/50 (10%) | 9/50 (18%) 7/50 (14%) 6/50 (12%) |
|ADJUSTED (b) | 17.8% 27.3% 15.8% | 24.2% 22.1% 17.8% |
|TERMINAL (d) | 4/31 (13%) 6/29 (21%) 3/26 (12%) | 5/32 (16%) 4/27 (15%) 5/32 (16%) |
|FIRST INCIDENCE (DAYS) | 667 644 472 | 618 660 643 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.549 P=0.255 P=0.607N | P=0.260N P=0.507N P=0.303N |
|INCIDENTAL TUMOR | P=0.483N P=0.257 P=0.519N | P=0.292N P=0.360N P=0.335N |
|LOGISTIC REGRESSION | P=0.485N P=0.272 P=0.520N | P=0.262N P=0.427N P=0.311N |
|COCHRAN-ARMITAGE | P=0.426N | P=0.240N |
|FISHER EXACT | P=0.303 P=0.486N | P=0.393N P=0.288N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.4% 5.7% 0.0% | 3.1% 0.0% 0.0% |
|TERMINAL (d) | 1/31 (3%) 1/29 (3%) 0/26 (0%) | 1/32 (3%) 0/27 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 630 614 --- | 731 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.109N P=0.532N P=0.156N | P=0.276N P=0.534N P=0.500N |
|INCIDENTAL TUMOR | P=0.067N P=0.431N P=0.109N | P=0.276N P=0.534N P=0.500N |
|LOGISTIC REGRESSION | P=0.081N P=0.492N P=0.126N | P=0.276N P=0.534N P=0.500N |
|COCHRAN-ARMITAGE | P=0.079N | P=0.269N |
|FISHER EXACT | P=0.490N P=0.117N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/49 (18%) 11/50 (22%) 5/50 (10%) | 10/50 (20%) 7/50 (14%) 6/50 (12%) |
|ADJUSTED (b) | 25.1% 32.1% 15.8% | 27.0% 22.1% 17.8% |
|TERMINAL (d) | 5/31 (16%) 7/29 (24%) 3/26 (12%) | 6/32 (19%) 4/27 (15%) 5/32 (16%) |
|FIRST INCIDENCE (DAYS) | 630 614 472 | 618 660 643 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.288N P=0.352 P=0.300N | P=0.185N P=0.414N P=0.221N |
|INCIDENTAL TUMOR | P=0.188N P=0.406 P=0.199N | P=0.208N P=0.276N P=0.246N |
|LOGISTIC REGRESSION | P=0.198N P=0.394 P=0.208N | P=0.184N P=0.333N P=0.227N |
|COCHRAN-ARMITAGE | P=0.162N | P=0.166N |
|FISHER EXACT | P=0.421 P=0.183N | P=0.298N P=0.207N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 3.1% 0.0% 7.4% | 0.0% 0.0% 6.3% |
|TERMINAL (d) | 0/31 (0%) 0/29 (0%) 1/26 (4%) | 0/32 (0%) 0/27 (0%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 726 --- 724 | --- --- 731 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.314 P=0.520N P=0.436 | P=0.102 (e) P=0.238 |
|INCIDENTAL TUMOR | P=0.324 P=0.523N P=0.452 | P=0.102 (e) P=0.238 |
|LOGISTIC REGRESSION | P=0.320 P=0.507N P=0.447 | P=0.102 (e) P=0.238 |
|COCHRAN-ARMITAGE | P=0.366 | P=0.095 |
|FISHER EXACT | P=0.495N P=0.508 | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 3.1% 2.5% 7.4% | 0.0% 3.7% 6.3% |
|TERMINAL (d) | 0/31 (0%) 0/29 (0%) 1/26 (4%) | 0/32 (0%) 1/27 (4%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | 726 623 724 | --- 731 (T) 731 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.328 P=0.741 P=0.436 | P=0.148 P=0.466 P=0.238 |
|INCIDENTAL TUMOR | P=0.381 P=0.720N P=0.452 | P=0.148 P=0.466 P=0.238 |
|LOGISTIC REGRESSION | P=0.360 P=0.756N P=0.447 | P=0.148 P=0.466 P=0.238 |
|COCHRAN-ARMITAGE | P=0.384 | P=0.142 |
|FISHER EXACT | P=0.747N P=0.508 | P=0.500 P=0.247 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 10/50 (20%) 7/50 (14%) 5/50 (10%) |
|ADJUSTED (b) | | 28.7% 20.7% 13.5% |
|TERMINAL (d) | | 8/32 (25%) 3/27 (11%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | | 585 503 588 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.120N P=0.415N P=0.143N |
|INCIDENTAL TUMOR | | P=0.112N P=0.271N P=0.178N |
|LOGISTIC REGRESSION | | P=0.109N P=0.316N P=0.144N |
|COCHRAN-ARMITAGE | | P=0.102N |
|FISHER EXACT | | P=0.298N P=0.131N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 11/50 (22%) 7/50 (14%) 5/50 (10%) |
|ADJUSTED (b) | | 30.4% 20.7% 13.5% |
|TERMINAL (d) | | 8/32 (25%) 3/27 (11%) 2/32 (6%) |
|FIRST INCIDENCE (DAYS) | | 585 503 588 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.081N P=0.326N P=0.101N |
|INCIDENTAL TUMOR | | P=0.073N P=0.178N P=0.132N |
|LOGISTIC REGRESSION | | P=0.068N P=0.229N P=0.095N |
|COCHRAN-ARMITAGE | | P=0.063N |
|FISHER EXACT | | P=0.218N P=0.086N |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.5% 0.0% 0.0% | 5.3% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/29 (0%) 0/26 (0%) | 1/32 (3%) 0/27 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 646 --- --- | 609 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.292N P=0.516N P=0.532N | P=0.103N P=0.261N P=0.247N |
|INCIDENTAL TUMOR | P=0.288N P=0.523N P=0.523N | P=0.102N P=0.272N P=0.240N |
|LOGISTIC REGRESSION | P=0.268N P=0.506N P=0.496N | P=0.087N P=0.220N P=0.220N |
|COCHRAN-ARMITAGE | P=0.269N | P=0.095N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 13/50 (26%) 15/50 (30%) 11/50 (22%) | 19/50 (38%) 12/50 (24%) 15/50 (30%) |
|ADJUSTED (b) | 34.3% 38.8% 31.1% | 45.8% 31.4% 35.9% |
|TERMINAL (d) | 8/31 (26%) 7/29 (24%) 5/26 (19%) | 11/32 (34%) 4/27 (15%) 6/32 (19%) |
|FIRST INCIDENCE (DAYS) | 530 489 483 | 585 566 588 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.527N P=0.372 P=0.558N | P=0.277N P=0.207N P=0.311N |
|INCIDENTAL TUMOR | P=0.323N P=0.447 P=0.359N | P=0.296N P=0.097N P=0.340N |
|LOGISTIC REGRESSION | P=0.368N P=0.413 P=0.408N | P=0.349N P=0.081N P=0.434N |
|COCHRAN-ARMITAGE | P=0.366N | P=0.224N |
|FISHER EXACT | P=0.412 P=0.408N | P=0.097N P=0.263N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 5.5% |
|TERMINAL (d) | 0/31 (0%) 0/29 (0%) 0/26 (0%) | 0/32 (0%) 0/27 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 628 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.100 (e) P=0.240 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.102 (e) P=0.240 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.096 (e) P=0.242 |
|COCHRAN-ARMITAGE | (e) | P=0.095 |
|FISHER EXACT | (e) (e) | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 5.5% |
|TERMINAL (d) | 0/31 (0%) 0/29 (0%) 0/26 (0%) | 0/32 (0%) 0/27 (0%) 1/32 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 628 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.100 (e) P=0.240 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.102 (e) P=0.240 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.096 (e) P=0.242 |
|COCHRAN-ARMITAGE | (e) | P=0.095 |
|FISHER EXACT | (e) (e) | (e) P=0.247 |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 5/50 (10%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.2% 8.6% 14.5% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/31 (3%) 0/29 (0%) 2/26 (8%) | 0/32 (0%) 0/27 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 733 (T) 614 467 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.056 P=0.296 P=0.086 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.092 P=0.322 P=0.124 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.073 P=0.305 P=0.107 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.070 | (e) |
|FISHER EXACT | P=0.309 P=0.102 | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 49/50 (98%) 48/50 (96%) | 44/50 (88%) 36/50 (72%) 40/50 (80%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 95.6% 83.3% 88.7% |
|TERMINAL (d) | 31/31 (100%) 29/29 (100%) 26/26 (100%) | 30/32 (94%) 20/27 (74%) 27/32 (84%) |
|FIRST INCIDENCE (DAYS) | 406 370 467 | 506 503 450 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.139 P=0.339 P=0.160 | P=0.317N P=0.393N P=0.330N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.239N P=0.043N* P=0.264N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.258N P=0.056N P=0.293N |
|COCHRAN-ARMITAGE | P=0.610 | P=0.191N |
|FISHER EXACT | P=0.500 P=0.691N | P=0.039N* P=0.207N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 24/50 (48%) 22/50 (44%) 22/50 (44%) | 22/50 (44%) 16/50 (32%) 20/50 (40%) |
|ADJUSTED (b) | 59.0% 52.2% 57.8% | 50.8% 39.0% 46.5% |
|TERMINAL (d) | 15/31 (48%) 10/29 (34%) 11/26 (42%) | 12/32 (38%) 5/27 (19%) 9/32 (28%) |
|FIRST INCIDENCE (DAYS) | 530 370 483 | 585 396 588 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.445 P=0.507N P=0.469 | P=0.430N P=0.299N P=0.458N |
|INCIDENTAL TUMOR | P=0.341N P=0.374N P=0.411N | P=0.483N P=0.116N P=0.573N |
|LOGISTIC REGRESSION | P=0.397N P=0.419N P=0.462N | P=0.498N P=0.103N P=0.522 |
|COCHRAN-ARMITAGE | P=0.382N | P=0.379N |
|FISHER EXACT | P=0.421N P=0.421N | P=0.151N P=0.420N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05028 TEST: 01 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE .01G/KG .02G/KG | VEHICLE .08G/KG .16G/KG |
| | MALE LM HM | FEMALE LF HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 49/50 (98%) 48/50 (96%) | 50/50 (100%) 44/50 (88%) 43/50 (86%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 100.0% 88.0% 89.6% |
|TERMINAL (d) | 31/31 (100%) 29/29 (100%) 26/26 (100%) | 32/32 (100%) 21/27 (78%) 27/32 (84%) |
|FIRST INCIDENCE (DAYS) | 406 370 467 | 506 396 450 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.139 P=0.339 P=0.160 | P=0.201N P=0.545N P=0.196N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.021N* P=0.009N** P=0.022N* |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.019N* P=0.009N** P=0.013N* |
|COCHRAN-ARMITAGE | P=0.610 | P=0.010N* |
|FISHER EXACT | P=0.500 P=0.691N | P=0.013N* P=0.006N** |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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