TDMS Study 05031-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/04/94
EXP: 05031 MERCURIC CHLORIDE TIME: 16:34:18
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60173
CONT: CAS: 7487-94-7
PATHOLOGIST: D. GOODMAN S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/04/94
EXP: 05031 MERCURIC CHLORIDE TIME: 16:34:18
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60173
CONT: CAS: 7487-94-7
PATHOLOGIST: D. GOODMAN S. EUSTIS
MERCURIC CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 14 CENSORED DEATHS 10 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 62 85 96 99 105 112 129 197 457 595 |
| 637 695 699 701 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 14 CENSORED DEATHS 10 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 12 12 49 88 187 187 230 325 456 509 |
| 547 673 686 693 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 6 9 31 48 129 136 138 173 309 471 |
| 471 544 548 551 555 642 687 704 728 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
MERCURIC CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 96.7 88.3 86.7 86.7 86.7 84.6 84.6 82.5 80.5 74.3 |
| | |
| | |
|5MG/KG | 93.3 93.3 88.3 86.7 86.7 85.0 82.9 80.9 80.9 74.6 |
| | |
| | |
|10MG/KG | 93.3 86.7 86.7 85.0 85.0 80.9 78.8 72.6 70.5 64.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 5MG/KG 10MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.3% 74.6% 64.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.339 P=1.000 P=0.398 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 333.5 332.4 362.1 |
|NATURAL DEATHS (C) | (73.5) (68.8) (60.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 591.2 591.0 567.3 |
|(STANDARD ERROR) | (28.0) (27.4) (29.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MERCURIC CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 10 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 211 535 560 565 593 671 700 705 717 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 10 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 7 400 464 558 632 639 670 673 678 680 |
| 701 704 709 715 719 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 11 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 82 325 325 364 471 492 551 562 573 637 |
| 651 656 661 669 670 672 688 719 |
| CENSORED DEATHS |
| 432 456 456 456 456 456 456 456 456 456 |
| 456 |
| |
==================================================================================
MERCURIC CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.3 98.3 98.3 98.3 96.3 90.3 90.3 82.3 |
| | |
| | |
|5MG/KG | 98.3 98.3 98.3 98.3 96.7 94.7 94.7 92.6 88.6 70.5 |
| | |
| | |
|10MG/KG | 98.3 98.3 98.3 93.3 93.3 91.3 89.2 83.0 74.7 64.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 5MG/KG 10MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 82.3% 70.5% 64.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.038 P=0.251 P=0.051 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 584.1 596.6 542.7 |
|NATURAL DEATHS (C) | (52.2) (48.7) (40.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 661.8 650.4 622.7 |
|(STANDARD ERROR) | (15.6) (17.9) (19.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MERCURIC CHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
5MG/KG = 2
10MG/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
103.66 +
|
|
|
99.51 +132 1
| 33 1 1
|
| 2 3 2 11
95.37 + 3 2 21 1
|
| 3 2 3 2
|
P 91.22 + 11 33
E | 1 1 2 2
R |
C | 13 3 1 2 2
E 87.07 + 3 1 3 2 1
N |
T | 3 1 3 2 1
|
S 82.93 + 2 2 1 1
U |
R | 3 32 1 2 1
V |
I 78.78 + 33 22
V |
A | 2211
L |
74.63 + 33 2 1 1
|
| 3 3
|
70.49 + 3 3
|
| 3 3
|
66.34 + 3 3
|
| 3 3
|
62.20 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.
MERCURIC CHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
5MG/KG = 2
10MG/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 12 3 1
| 2 3 1 3 2 1
|
| 2 2 1 1
95 + 3 3 2 2
| 3 3 11
| 21 1 2
| 3 3 22
P 90 + 1 1
E | 3 3 2 1 1
R | 3 3
C | 22 11
E 85 + 33
N | 1 1
T | 3 3 22 1 1
| 3 3
S 80 + 2 2
U | 33
R |
V | 3 3 22
I 75 + 33 22
V |
A |
L |
70 + 2 2
| 3 3
|
| 3 3
65 +
| 3 3
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.