Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3011

TDMS Study 05031-02 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         MERCURIC CHLORIDE


NTP Experiment-Test: 05031-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 17:35:59




       Facility:  International Research and Development Corp.

       Chemical CAS #:  7487-94-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           14            9                                                  
    Dead                                               1            7           11                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           27           29                                                  
    Moribund                                                        1            1                                                  
  Wrong Sex                                                         1                                                               
  Animals Examined Microscopically                    50           49           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (49)         (50)                                                
      Inflammation, Chronic                                                      2 (4%)                                             
   Intestine Large, Colon                             (50)         (49)         (50)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Parasite Metazoan                                1 (2%)       1 (2%)       2 (4%)                                             
   Intestine Large, Rectum                            (50)         (46)         (50)                                                
      Parasite Metazoan                                2 (4%)       2 (4%)       2 (4%)                                             
   Intestine Small, Duodenum                          (50)         (49)         (50)                                                
      Autolysis                                                     1 (2%)       3 (6%)                                             
   Intestine Small, Ileum                             (50)         (49)         (50)                                                
      Autolysis                                                     1 (2%)       3 (6%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Intestine Small, Jejunum                           (50)         (49)         (50)                                                
      Autolysis                                                     2 (4%)       4 (8%)                                             
   Liver                                              (50)         (49)         (50)                                                
      Angiectasis                                      1 (2%)       1 (2%)       1 (2%)                                             
      Basophilic Focus, Multiple                      27 (54%)     28 (57%)     32 (64%)                                            
      Clear Cell Focus                                                           9 (18%)                                            
      Congestion                                                    4 (8%)       1 (2%)                                             
      Cytoplasmic Alteration, Focal                    3 (6%)       4 (8%)       1 (2%)                                             
      Degeneration, Fatty                                           1 (2%)       2 (4%)                                             
      Ectasia, Focal                                                             1 (2%)                                             
      Eosinophilic Focus                                                         1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Hepatodiaphragmatic Nodule                       8 (16%)      4 (8%)       8 (16%)                                            
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                     18 (36%)     23 (47%)     17 (34%)                                            
      Mixed Cell Focus                                                           1 (2%)                                             
      Mixed Cell Focus, Multiple                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Necrosis, Acute                                  1 (2%)       1 (2%)       2 (4%)                                             
      Vacuolization Cytoplasmic, Focal                 2 (4%)       3 (6%)       3 (6%)                                             
      Bile Duct, Hyperplasia                           1 (2%)       4 (8%)       3 (6%)                                             
      Hepatocyte, Hyperplasia                                       1 (2%)                                                          
   Mesentery                                          (2)          (2)          (2)                                                 
      Fat, Necrosis, Focal                             2 (100%)     2 (100%)     1 (50%)                                            
   Pancreas                                           (50)         (49)         (50)                                                
      Atrophy, Focal                                  20 (40%)     17 (35%)     20 (40%)                                            
      Autolysis                                                     1 (2%)       1 (2%)                                             
      Cytoplasmic Alteration, Focal                                              1 (2%)                                             
      Ectopic Liver                                                              1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte                                   1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (50)                                                
      Cytoplasmic Alteration, Focal                                              2 (4%)                                             
      Hemorrhage, Focal                                1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (49)         (50)                                                
      Edema                                            1 (2%)                                                                       
      Hyperplasia                                      5 (10%)      5 (10%)     20 (40%)                                            
      Inflammation, Acute                              2 (4%)       1 (2%)       2 (4%)                                             
      Ulcer                                            1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (49)         (50)                                                
      Autolysis                                                     1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Necrosis                                         3 (6%)       1 (2%)       4 (8%)                                             
   Tongue                                             (1)                                                                           
      Hemorrhage, Focal                                1 (100%)                                                                     
   Tooth                                                           (1)                                                              
      Inflammation, Acute                                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (15)         (18)         (19)                                                
      Aorta, Inflammation, Chronic                     1 (7%)                                                                       
      Mesenteric Artery, Inflammation, Chronic         1 (7%)                                                                       
   Heart                                              (50)         (49)         (50)                                                
      Inflammation, Chronic                           31 (62%)     38 (78%)     39 (78%)                                            
      Atrium Left, Thrombosis                                       4 (8%)       2 (4%)                                             
      Coronary Artery, Inflammation, Chronic           1 (2%)                                                                       
      Endocardium, Fibrosis                            1 (2%)                                                                       
      Epicardium, Inflammation, Chronic                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (49)         (50)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Angiectasis                                                   5 (10%)      3 (6%)                                             
      Congestion                                                    5 (10%)                                                         
      Degeneration, Fatty                              1 (2%)       2 (4%)                                                          
      Hyperplasia, Focal                               5 (10%)     11 (22%)     11 (22%)                                            
      Hypertrophy, Focal                               3 (6%)       3 (6%)       4 (8%)                                             
      Necrosis, Focal                                               1 (2%)                                                          
      Vacuolization Cytoplasmic, Focal                10 (20%)      7 (14%)      4 (8%)                                             
   Adrenal Gland, Medulla                             (48)         (49)         (49)                                                
      Cyst                                             1 (2%)                                                                       
      Hyperplasia, Focal                               4 (8%)       8 (16%)      5 (10%)                                            
      Bilateral, Hyperplasia, Focal                    1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (49)         (50)                                                
      Hyperplasia, Focal                               2 (4%)                    2 (4%)                                             
   Parathyroid Gland                                  (47)         (49)         (45)                                                
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Pars Distalis, Angiectasis                       8 (16%)      7 (14%)      2 (4%)                                             
      Pars Distalis, Cyst                             13 (26%)     16 (33%)      5 (10%)                                            
      Pars Distalis, Ectasia                           1 (2%)       1 (2%)                                                          
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia                      10 (20%)     10 (20%)      9 (18%)                                            
      Pars Distalis, Hypertrophy                                    1 (2%)       3 (6%)                                             
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
   Thyroid Gland                                      (50)         (48)         (49)                                                
      Ultimobranchial Cyst                                          1 (2%)                                                          
      C-Cell, Hyperplasia                             15 (30%)      3 (6%)       5 (10%)                                            
      Follicle, Cyst                                                1 (2%)       4 (8%)                                             
      Follicular Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (46)         (45)                                                
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Acute                                           2 (4%)                                                          
      Inflammation, Chronic                            1 (2%)       2 (4%)       1 (2%)                                             
      Duct, Ectasia                                    2 (4%)       2 (4%)       2 (4%)                                             
   Ovary                                              (50)         (49)         (50)                                                
      Hemorrhage                                                    1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Bilateral, Periovarian Tissue, Cyst              1 (2%)                                                                       
      Follicle, Cyst                                   1 (2%)       3 (6%)       3 (6%)                                             
      Periovarian Tissue, Cyst                         1 (2%)                                                                       
   Uterus                                             (50)         (49)         (50)                                                
      Cyst                                                                       1 (2%)                                             
      Dilatation                                                    1 (2%)                                                          
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hyperplasia, Cystic                              1 (2%)                                                                       
      Inflammation, Acute                                           1 (2%)                                                          
      Cervix, Cyst                                                               1 (2%)                                             
      Endometrium, Cyst                                1 (2%)       2 (4%)       4 (8%)                                             
      Endometrium, Hyperplasia, Cystic                 3 (6%)       2 (4%)       7 (14%)                                            
   Vagina                                             (2)                       (1)                                                 
      Inflammation, Acute                                                        1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
      Hypoplasia                                                    1 (2%)                                                          
      Myelofibrosis                                    4 (8%)       1 (2%)                                                          
      Myeloid Cell, Hyperplasia                        1 (2%)       1 (2%)                                                          
   Lymph Node                                         (44)         (48)         (49)                                                
      Inguinal, Hyperplasia, Lymphoid                                            1 (2%)                                             
      Mandibular, Hyperplasia, Lymphoid                1 (2%)                                                                       
      Mandibular, Hyperplasia, Plasma Cell                          1 (2%)                                                          
      Mediastinal, Congestion                                                    1 (2%)                                             
      Mediastinal, Hemorrhage                                       1 (2%)                                                          
   Lymph Node, Mesenteric                             (40)         (28)         (47)                                                
      Ectasia                                          2 (5%)                                                                       
      Hyperplasia, Plasma Cell                         1 (3%)                                                                       
      Hyperplasia, Re Cell                                                       2 (4%)                                             
      Inflammation                                     1 (3%)                                                                       
   Spleen                                             (50)         (49)         (50)                                                
      Hematopoietic Cell Proliferation Granulocytic    1 (2%)                    2 (4%)                                             
      Capsule, Fibrosis, Focal                         1 (2%)                                                                       
   Thymus                                             (48)         (43)         (48)                                                
      Congestion                                       1 (2%)                                                                       
      Cyst                                                          1 (2%)       3 (6%)                                             
      Hemorrhage                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Galactocele                                      2 (4%)       2 (4%)       1 (2%)                                             
      Hyperplasia                                      4 (8%)       3 (6%)       2 (4%)                                             
      Inflammation, Acute                                           1 (2%)       1 (2%)                                             
      Duct, Ectasia                                   11 (22%)      8 (17%)      7 (14%)                                            
   Skin                                               (50)         (49)         (50)                                                
      Inflammation, Acute                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)                                                
      Inflammation, Acute                                           1 (2%)                                                          
      Osteopetrosis                                    2 (4%)       1 (2%)       3 (6%)                                             
   Skeletal Muscle                                    (2)                                                                           
      Inflammation, Chronic                            2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
      Demyelination, Focal                                          1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Hydrocephalus                                                 1 (2%)       1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      White Matter, Vacuolization Cytoplasmic                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)                                                
      Congestion                                       7 (14%)     16 (33%)     18 (36%)                                            
      Ectopic Tissue                                                1 (2%)                                                          
      Hemorrhage                                       2 (4%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic                            3 (6%)       1 (2%)       4 (8%)                                             
      Inflammation, Focal                                           1 (2%)                                                          
      Inflammation, Granulomatous                      2 (4%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       4 (8%)       2 (4%)                                             
      Alveolus, Infiltration Cellular, Histiocyte      2 (4%)       2 (4%)       4 (8%)                                             
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                1 (2%)       2 (4%)                                             
   Nose                                               (49)         (49)         (50)                                                
      Autolysis                                        1 (2%)                    3 (6%)                                             
      Foreign Body                                                               4 (8%)                                             
      Fungus                                                        3 (6%)       2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      2.5MG/KG     5.0MG/KG                                               
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mucosa, Cyst                                     1 (2%)                                                                       
      Mucosa, Inflammation, Acute                                   1 (2%)       3 (6%)                                             
      Mucosa, Inflammation, Chronic Active                          4 (8%)      12 (24%)                                            
      Mucosa, Mineralization, Focal                                 1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Acute           2 (4%)       2 (4%)                                                          
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)                    1 (2%)                                             
      Respiratory Epithelium, Degeneration                          1 (2%)                                                          
      Respiratory Epithelium, Hyperplasia                                        1 (2%)                                             
      Respiratory Epithelium, Metaplasia, Squamous                  1 (2%)       1 (2%)                                             
   Trachea                                            (50)         (49)         (50)                                                
      Inflammation, Acute                                                        2 (4%)                                             
      Inflammation, Granulomatous                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (3)          (2)                                                 
      Hemorrhage                                       2 (40%)      1 (33%)                                                         
      Lens, Cataract                                   3 (60%)      3 (100%)     2 (100%)                                           
      Lens, Degeneration                               1 (20%)                                                                      
      Retina, Degeneration                             4 (80%)      2 (67%)      1 (50%)                                            
      Sclera, Degeneration                             1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)                                                
      Autolysis                                        1 (2%)                    1 (2%)                                             
      Congestion                                                    3 (6%)                                                          
      Cyst                                                                       2 (4%)                                             
      Degeneration, Hyaline                                         1 (2%)                                                          
      Hemorrhage, Focal                                                          1 (2%)                                             
      Karyomegaly                                                   4 (8%)                                                          
      Mineralization                                                2 (4%)                                                          
      Nephropathy                                     49 (98%)     43 (88%)     41 (82%)                                            
      Pigmentation                                     3 (6%)       1 (2%)       3 (6%)                                             
      Renal Tubule, Hyperplasia                                                  2 (4%)                                             
      Renal Tubule, Hyperplasia, Oncocytic                          1 (2%)                                                          
      Renal Tubule, Hypertrophy                                     1 (2%)                                                          
   Urinary Bladder                                    (50)         (48)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          20           19           32                                                  
    Dead                                               4           21           13                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           10            5                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (50)         (50)                                                
      Autolysis                                                     3 (6%)       2 (4%)                                             
      Congestion                                                                 2 (4%)                                             
      Edema                                            1 (2%)       1 (2%)                                                          
      Hemorrhage                                                    3 (6%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            2 (4%)                    1 (2%)                                             
      Inflammation, Acute                                           6 (12%)      7 (14%)                                            
      Inflammation, Chronic                            1 (2%)       2 (4%)       3 (6%)                                             
      Parasite Metazoan                                                          1 (2%)                                             
      Ulcer                                                         8 (16%)      4 (8%)                                             
   Intestine Large, Colon                             (50)         (50)         (50)                                                
      Autolysis                                                     2 (4%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
      Inflammation, Acute                                           1 (2%)       2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                    3 (6%)                                             
      Mineralization                                                2 (4%)                                                          
      Parasite Metazoan                                1 (2%)       8 (16%)      5 (10%)                                            
   Intestine Large, Rectum                            (50)         (46)         (50)                                                
      Autolysis                                                     1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute, Chronic                                               1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       2 (4%)       2 (4%)                                             
      Mineralization                                                1 (2%)                                                          
      Parasite Metazoan                                             4 (9%)                                                          
      Ulcer                                                         1 (2%)       1 (2%)                                             
   Intestine Small, Duodenum                          (50)         (49)         (50)                                                
      Autolysis                                                     4 (8%)       2 (4%)                                             
      Necrosis                                         1 (2%)                                                                       
   Intestine Small, Ileum                             (49)         (50)         (49)                                                
      Autolysis                                                     5 (10%)      3 (6%)                                             
      Hyperplasia, Lymphoid                            4 (8%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (50)         (50)                                                
      Autolysis                                                     9 (18%)      4 (8%)                                             
      Metaplasia, Osseous                              1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                   6 (12%)                                                         
      Autolysis                                                     1 (2%)                                                          
      Basophilic Focus                                                           1 (2%)                                             
      Basophilic Focus, Multiple                      17 (34%)      7 (14%)      6 (12%)                                            
      Clear Cell Focus                                 1 (2%)                                                                       
      Congestion                                       2 (4%)       3 (6%)       1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Cytoplasmic Alteration, Focal                    7 (14%)      3 (6%)       2 (4%)                                             
      Ectasia                                          2 (4%)       1 (2%)                                                          
      Eosinophilic Focus                               1 (2%)       2 (4%)       2 (4%)                                             
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       8 (16%)      6 (12%)      7 (14%)                                            
      Hyperplasia, Focal                               1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Inflammation, Granulomatous, Multifocal          1 (2%)                                                                       
      Necrosis, Acute                                  4 (8%)       6 (12%)     11 (22%)                                            
      Thrombosis, Focal                                1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                 3 (6%)       1 (2%)                                                          
      Bile Duct, Hyperplasia                          17 (34%)     22 (44%)     15 (30%)                                            
      Hepatocyte, Degeneration, Cystic                 5 (10%)      7 (14%)      4 (8%)                                             
   Mesentery                                          (2)          (10)         (6)                                                 
      Hemorrhage, Focal                                             1 (10%)                                                         
      Inflammation, Acute, Focal                                                 1 (17%)                                            
      Inflammation, Chronic                                         1 (10%)                                                         
      Fat, Necrosis                                                 1 (10%)      1 (17%)                                            
      Fat, Necrosis, Focal                             2 (100%)     8 (80%)      3 (50%)                                            
   Pancreas                                           (50)         (50)         (50)                                                
      Atrophy, Focal                                  25 (50%)     15 (30%)     18 (36%)                                            
      Autolysis                                                     2 (4%)       2 (4%)                                             
      Cytoplasmic Alteration, Focal                    1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Focal, Granulomatous                                         1 (2%)                                             
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Duct, Hyperplasia                                1 (2%)                                                                       
      Duct, Metaplasia, Squamous                                                 1 (2%)                                             
   Stomach, Forestomach                               (49)         (50)         (50)                                                
      Autolysis                                                                  1 (2%)                                             
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Edema                                            2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia                                      3 (6%)      16 (32%)     35 (70%)                                            
      Inflammation, Acute                              2 (4%)       3 (6%)       4 (8%)                                             
      Mineralization                                                5 (10%)      2 (4%)                                             
      Ulcer                                            1 (2%)                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
      Autolysis                                                                  1 (2%)                                             
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
      Inflammation, Acute                              2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                         2 (4%)       1 (2%)                                             
      Mineralization                                                9 (18%)      5 (10%)                                            
      Necrosis                                         3 (6%)       2 (4%)       5 (10%)                                            
      Ulcer                                                         1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (16)         (41)         (42)                                                
      Mineralization                                                6 (15%)      2 (5%)                                             
   Heart                                              (50)         (50)         (50)                                                
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                           44 (88%)     48 (96%)     48 (96%)                                            
      Mineralization                                               13 (26%)     14 (28%)                                            
      Atrium Left, Thrombosis                          1 (2%)       5 (10%)      2 (4%)                                             
      Endocardium, Fibrosis                            1 (2%)                                                                       
      Epicardium, Inflammation, Chronic, Focal         1 (2%)                                                                       
      Valve, Thrombosis                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
      Congestion                                       1 (2%)       1 (2%)       2 (4%)                                             
      Hyperplasia, Focal                              10 (20%)      3 (6%)       8 (16%)                                            
      Hypertrophy, Focal                               5 (10%)                   1 (2%)                                             
      Inflammation, Chronic, Multifocal                                          1 (2%)                                             
      Mineralization, Multifocal                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                       10 (20%)      8 (16%)     10 (20%)                                            
      Capsule, Ectopic Tissue                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (48)         (50)         (49)                                                
      Hyperplasia, Focal                               8 (17%)      8 (16%)      6 (12%)                                            
      Thrombosis                                       1 (2%)                                                                       
      Bilateral, Hyperplasia, Focal                    1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Autolysis                                                     2 (4%)       1 (2%)                                             
      Hyperplasia                                      3 (6%)                    2 (4%)                                             
   Parathyroid Gland                                  (49)         (44)         (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      2 (4%)      23 (52%)     19 (39%)                                            
      Hyperplasia, Focal                                            2 (5%)                                                          
   Pituitary Gland                                    (50)         (49)         (50)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Pars Distalis, Angiectasis                       2 (4%)       2 (4%)       1 (2%)                                             
      Pars Distalis, Cyst                              1 (2%)       4 (8%)                                                          
      Pars Distalis, Cytoplasmic Alteration, Focal     1 (2%)                                                                       
      Pars Distalis, Ectasia                           1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      12 (24%)      9 (18%)      6 (12%)                                            
      Pars Distalis, Hypertrophy                       2 (4%)       2 (4%)                                                          
      Pars Distalis, Necrosis, Focal                   1 (2%)                                                                       
      Pars Nervosa, Cyst                                            1 (2%)       1 (2%)                                             
      Pars Nervosa, Hyperplasia                                     3 (6%)                                                          
      Pars Nervosa, Inflammation, Granulomatous                                  1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Hemorrhage                                                    2 (4%)                                                          
      Ultimobranchial Cyst                             1 (2%)       1 (2%)       1 (2%)                                             
      C-Cell, Hyperplasia                              6 (12%)      2 (4%)       1 (2%)                                             
      Follicle, Cyst                                   1 (2%)       1 (2%)       2 (4%)                                             
      Follicular Cell, Hyperplasia                     2 (4%)       3 (6%)       2 (4%)                                             
      Follicular Cell, Hyperplasia, Cystic                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (50)                                                
      Cytomegaly                                                    1 (2%)                                                          
      Duct, Epithelium, Degeneration                   1 (2%)       3 (6%)       2 (4%)                                             
      Fat, Necrosis, Focal                             3 (6%)                                                                       
   Preputial Gland                                    (49)         (46)         (48)                                                
      Hyperplasia                                      2 (4%)                                                                       
      Inflammation, Acute                             11 (22%)     12 (26%)      9 (19%)                                            
      Inflammation, Chronic                            9 (18%)      2 (4%)       8 (17%)                                            
      Inflammation, Chronic Active                     2 (4%)                                                                       
      Duct, Ectasia                                    1 (2%)       2 (4%)                                                          
      Duct, Hyperplasia                                                          1 (2%)                                             
   Prostate                                           (49)         (50)         (50)                                                
      Hyperplasia, Focal                               8 (16%)      1 (2%)                                                          
      Inflammation, Acute                              5 (10%)      4 (8%)       1 (2%)                                             
      Inflammation, Chronic                            2 (4%)       4 (8%)       2 (4%)                                             
      Inflammation, Chronic Active                     3 (6%)       1 (2%)                                                          
   Testes                                             (50)         (49)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Atrophy                                          3 (6%)       3 (6%)       1 (2%)                                             
      Bilateral, Atrophy                                                         2 (4%)                                             
      Bilateral, Interstitial Cell, Hyperplasia        3 (6%)       1 (2%)       1 (2%)                                             
      Interstitial Cell, Hyperplasia                   3 (6%)       4 (8%)       8 (16%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
      Congestion                                                                 1 (2%)                                             
      Depletion Cellular, Focal                                                  2 (4%)                                             
      Hypoplasia                                       1 (2%)                                                                       
      Myelofibrosis                                                              1 (2%)                                             
      Myeloid Cell, Hyperplasia                        5 (10%)      5 (10%)      4 (8%)                                             
   Lymph Node                                         (49)         (48)         (49)                                                
      Granuloma                                                     1 (2%)                                                          
      Inflammation                                                  1 (2%)                                                          
      Axillary, Congestion                             1 (2%)                                                                       
      Axillary, Hemorrhage                             1 (2%)                                                                       
      Iliac, Hyperplasia                                                         1 (2%)                                             
      Inguinal, Hyperplasia, Lymphoid                  1 (2%)                    1 (2%)                                             
      Mandibular, Hemorrhage                                        1 (2%)                                                          
      Mandibular, Inflammation, Acute, Focal                        1 (2%)                                                          
      Mediastinal, Hyperplasia                                                   1 (2%)                                             
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                         1 (2%)                                                                       
      Renal, Hemorrhage                                                          1 (2%)                                             
      Renal, Hyperplasia                                                         1 (2%)                                             
      Renal, Pigmentation                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (42)         (42)         (44)                                                
      Autolysis                                                     1 (2%)                                                          
      Congestion                                                                 1 (2%)                                             
      Ectasia                                          1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Lymphoid                            2 (5%)       1 (2%)       2 (5%)                                             
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                                         2 (5%)                                                          
   Spleen                                             (50)         (50)         (50)                                                
      Atrophy, Focal                                                1 (2%)       1 (2%)                                             
      Congestion                                       4 (8%)       1 (2%)                                                          
      Fibrosis                                         2 (4%)       2 (4%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                              2 (4%)       1 (2%)                                             
      Hematopoietic Cell Proliferation Granulocytic    2 (4%)       1 (2%)       2 (4%)                                             
      Necrosis, Focal                                                            1 (2%)                                             
      Pigmentation                                                  1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Capsule, Fibrosis                                             1 (2%)       1 (2%)                                             
   Thymus                                             (46)         (46)         (45)                                                
      Autolysis                                                                  1 (2%)                                             
      Congestion                                       1 (2%)       3 (7%)                                                          
      Cyst                                             3 (7%)                    1 (2%)                                             
      Ectopic Parathyroid Gland                        1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (50)         (45)                                                
      Hyperplasia                                      2 (4%)       1 (2%)       1 (2%)                                             
      Duct, Ectasia                                    5 (11%)      2 (4%)       1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Cyst                                             2 (4%)                                                                       
      Hyperkeratosis                                                             1 (2%)                                             
      Face, Inflammation, Acute                        2 (4%)                    4 (8%)                                             
      Tail, Hemorrhage                                                           1 (2%)                                             
      Tail, Subcutaneous Tissue, Necrosis                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)                                                
      Fibrous Osteodystrophy                           1 (2%)      27 (55%)     21 (42%)                                            
      Osteomalacia                                                               1 (2%)                                             
   Skeletal Muscle                                                 (1)          (1)                                                 
      Hemorrhage                                                    1 (100%)                                                        
      Inflammation, Acute, Focal                                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Hydrocephalus                                    4 (8%)                                                                       
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Meninges, Congestion                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       8 (16%)     13 (26%)      5 (10%)                                            
      Fibrosis, Focal                                               1 (2%)       1 (2%)                                             
      Foreign Body                                     1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Hemorrhage                                       5 (10%)      4 (8%)       5 (10%)                                            
      Inflammation, Acute, Chronic                                  1 (2%)                                                          
      Inflammation, Acute, Multifocal                  1 (2%)       5 (10%)      1 (2%)                                             
      Inflammation, Chronic                            4 (8%)       3 (6%)       3 (6%)                                             
      Inflammation, Granulomatous                      2 (4%)                    1 (2%)                                             
      Metaplasia, Focal, Osseous                       1 (2%)                                                                       
      Necrosis, Focal                                  1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (6%)       5 (10%)      5 (10%)                                            
      Alveolus, Infiltration Cellular, Histiocyte                   3 (6%)       1 (2%)                                             
      Artery, Media, Hypertrophy                       1 (2%)                                                                       
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                   1 (2%)       2 (4%)       1 (2%)                                             
   Nose                                               (50)         (47)         (50)                                                
      Autolysis                                        1 (2%)       6 (13%)      6 (12%)                                            
      Foreign Body                                     1 (2%)       3 (6%)       2 (4%)                                             
      Fungus                                           1 (2%)       1 (2%)       1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Squamous                                         1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mucosa, Cyst                                     1 (2%)                                                                       
      Mucosa, Inflammation, Acute                                   4 (9%)       2 (4%)                                             
      Mucosa, Inflammation, Chronic                    2 (4%)                                                                       
      Mucosa, Inflammation, Chronic Active             7 (14%)      4 (9%)      16 (32%)                                            
      Nasolacrimal Duct, Cyst                                       1 (2%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                    3 (6%)                                             
      Nasolacrimal Duct, Inflammation, Chronic         3 (6%)                    1 (2%)                                             
      Respiratory Epithelium, Hyperplasia              5 (10%)      1 (2%)       3 (6%)                                             
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       1 (2%)                                                          
   Trachea                                            (50)         (50)         (50)                                                
      Inflammation, Acute                                                        2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (1)                                                              
      Hemorrhage                                       1 (25%)                                                                      
      Bilateral, Lens, Cataract                                     1 (100%)                                                        
      Lens, Cataract                                   1 (25%)                                                                      
      Retina, Degeneration                             3 (75%)                                                                      
      Sclera, Inflammation, Acute                      1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05031-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 17:35:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      2.5MG/KG     5 MG/KG                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Congestion                                                    3 (6%)       1 (2%)                                             
      Inflammation, Acute, Focal                       1 (2%)       1 (2%)                                                          
      Mineralization                                                             3 (6%)                                             
      Nephropathy                                     50 (100%)    46 (92%)     48 (96%)                                            
      Pigmentation                                     2 (4%)                                                                       
      Cortex, Cyst                                     3 (6%)       5 (10%)      4 (8%)                                             
      Renal Tubule, Hyperplasia                        1 (2%)                    4 (8%)                                             
      Renal Tubule, Hyperplasia, Cystic                             1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Concretion                                       1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------