TDMS Study 05031-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC MERCURIC CHLORIDE DATE: 09/04/94
EXPERIMENT: 05031 TEST: 02 TIME: 17:46:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: ROUTE: GAVAGE NTP C#: 60173
PATHOLOGIST: P. HILDEBRANDT S. EUSTIS CAS: 7487-94-7
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC MERCURIC CHLORIDE DATE: 09/04/94
EXPERIMENT: 05031 TEST: 02 TIME: 17:46:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: ROUTE: GAVAGE NTP C#: 60173
PATHOLOGIST: P. HILDEBRANDT S. EUSTIS CAS: 7487-94-7
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC MERCURIC CHLORIDE DATE: 09/04/94
EXPERIMENT: 05031 TEST: 02 TIME: 17:46:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: ROUTE: GAVAGE NTP C#: 60173
PATHOLOGIST: P. HILDEBRANDT S. EUSTIS CAS: 7487-94-7
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF MERCURIC CHLORIDE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Brain Astrocytoma NOS
Intestine Small Carcinoma
Islets, Pancreatic Adenoma
Liver Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Skin Keratoacanthoma
Skin: Subcutaneous Tissue Fibroma
Stomach, Forestomach Squamous Cell Papilloma
Testes Adenoma
Thyroid Gland: C-Cell Carcinoma or Adenoma
Thyroid Gland: Follicular Cell
Carcinoma
Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC MERCURIC CHLORIDE DATE: 09/04/94
EXPERIMENT: 05031 TEST: 02 TIME: 17:46:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: ROUTE: GAVAGE NTP C#: 60173
PATHOLOGIST: P. HILDEBRANDT S. EUSTIS CAS: 7487-94-7
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF MERCURIC CHLORIDE
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 1/49 (2%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 6.5% 5.6% 0.0% | 2.9% 3.1% 0.0% |
|TERMINAL (d) | 1/26 (4%) 0/10 (0%) 0/5 (0%) | 1/35 (3%) 0/28 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 672 685 --- | 729 (T) 687 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.400N P=0.724 P=0.540N | P=0.361N P=0.722 P=0.531N |
|INCIDENTAL TUMOR | P=0.184N P=0.511N P=0.353N | P=0.385N P=0.754 P=0.531N |
|LOGISTIC REGRESSION | P=0.235N P=0.623N P=0.359N | P=0.356N P=0.738 P=0.531N |
|COCHRAN-ARMITAGE | P=0.142N | P=0.327N |
|FISHER EXACT | P=0.500N P=0.247N | P=0.753N P=0.495N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/48 (44%) 18/50 (36%) 23/49 (47%) | 2/48 (4%) 1/49 (2%) 3/49 (6%) |
|ADJUSTED (b) | 55.0% 88.2% 88.8% | 5.9% 3.3% 9.6% |
|TERMINAL (d) | 8/24 (33%) 8/10 (80%) 3/5 (60%) | 2/34 (6%) 0/28 (0%) 2/29 (7%) |
|FIRST INCIDENCE (DAYS) | 586 544 526 | 729 (T) 717 636 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.037 * P<0.001 ** | P=0.337 P=0.563N P=0.424 |
|INCIDENTAL TUMOR | P=0.229 P=0.572N P=0.559 | P=0.350 P=0.527N P=0.465 |
|LOGISTIC REGRESSION | P=0.074 P=0.401 P=0.156 | P=0.352 P=0.546N P=0.447 |
|COCHRAN-ARMITAGE | P=0.412 | P=0.407 |
|FISHER EXACT | P=0.282N P=0.456 | P=0.492N P=0.510 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/48 (6%) 0/50 (0%) 1/49 (2%) | 0/48 (0%) 0/49 (0%) 0/49 (0%) |
|ADJUSTED (b) | 12.5% 0.0% 4.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/24 (13%) 0/10 (0%) 0/5 (0%) | 0/34 (0%) 0/28 (0%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 644 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.536N P=0.309N P=0.690 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.399N P=0.309N P=0.635N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.363N P=0.309N P=0.568N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.170N | (e) |
|FISHER EXACT | P=0.114N P=0.301N | (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/48 (50%) 18/50 (36%) 23/49 (47%) | 2/48 (4%) 1/49 (2%) 3/49 (6%) |
|ADJUSTED (b) | 63.4% 88.2% 88.8% | 5.9% 3.3% 9.6% |
|TERMINAL (d) | 11/24 (46%) 8/10 (80%) 3/5 (60%) | 2/34 (6%) 0/28 (0%) 2/29 (7%) |
|FIRST INCIDENCE (DAYS) | 586 544 526 | 729 (T) 717 636 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.073 P<0.001 ** | P=0.337 P=0.563N P=0.424 |
|INCIDENTAL TUMOR | P=0.349 P=0.411N P=0.533N | P=0.350 P=0.527N P=0.465 |
|LOGISTIC REGRESSION | P=0.178 P=0.570N P=0.293 | P=0.352 P=0.546N P=0.447 |
|COCHRAN-ARMITAGE | P=0.424N | P=0.407 |
|FISHER EXACT | P=0.116N P=0.461N | P=0.492N P=0.510 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Brain |
| Astrocytoma NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 15.7% | 0.0% 3.6% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/10 (0%) 0/5 (0%) | 0/35 (0%) 1/28 (4%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 633 | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.033 * (e) P=0.086 | P=0.704 P=0.455 (e) |
|INCIDENTAL TUMOR | P=0.172 (e) P=0.380 | P=0.704 P=0.455 (e) |
|LOGISTIC REGRESSION | P=0.066 (e) P=0.173 | P=0.704 P=0.455 (e) |
|COCHRAN-ARMITAGE | P=0.095 | P=0.730 |
|FISHER EXACT | (e) P=0.247 | P=0.495 (e) |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 2/46 (4%) 2/48 (4%) | 1/46 (2%) 2/46 (4%) 3/45 (7%) |
|ADJUSTED (b) | 9.8% 17.0% 6.9% | 3.1% 6.2% 9.7% |
|TERMINAL (d) | 2/26 (8%) 1/9 (11%) 0/5 (0%) | 1/32 (3%) 0/27 (0%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 586 693 599 | 729 (T) 684 631 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.351 P=0.516 P=0.543 | P=0.188 P=0.457 P=0.256 |
|INCIDENTAL TUMOR | P=0.478N P=0.632 P=0.493N | P=0.159 P=0.523 P=0.271 |
|LOGISTIC REGRESSION | P=0.533N P=0.685 P=0.545N | P=0.190 P=0.467 P=0.265 |
|COCHRAN-ARMITAGE | P=0.416N | P=0.215 |
|FISHER EXACT | P=0.530N P=0.510N | P=0.500 P=0.300 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/46 (0%) 1/48 (2%) | 1/46 (2%) 1/46 (2%) 3/45 (7%) |
|ADJUSTED (b) | 0.0% 0.0% 20.0% | 3.1% 3.7% 9.8% |
|TERMINAL (d) | 0/26 (0%) 0/9 (0%) 1/5 (20%) | 1/32 (3%) 1/27 (4%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) | 729 (T) 729 (T) 636 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.073 (e) P=0.179 | P=0.168 P=0.724 P=0.254 |
|INCIDENTAL TUMOR | P=0.073 (e) P=0.179 | P=0.178 P=0.724 P=0.271 |
|LOGISTIC REGRESSION | P=0.073 (e) P=0.179 | P=0.172 P=0.724 P=0.264 |
|COCHRAN-ARMITAGE | P=0.268 | P=0.195 |
|FISHER EXACT | (e) P=0.495 | P=0.753N P=0.300 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 2/46 (4%) 3/48 (6%) | 2/46 (4%) 3/46 (7%) 6/45 (13%) |
|ADJUSTED (b) | 9.8% 17.0% 25.5% | 6.3% 9.6% 19.0% |
|TERMINAL (d) | 2/26 (8%) 1/9 (11%) 1/5 (20%) | 2/32 (6%) 1/27 (4%) 4/28 (14%) |
|FIRST INCIDENCE (DAYS) | 586 693 599 | 729 (T) 684 631 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.139 P=0.516 P=0.244 | P=0.066 P=0.436 P=0.094 |
|INCIDENTAL TUMOR | P=0.420 P=0.632 P=0.573 | P=0.057 P=0.487 P=0.105 |
|LOGISTIC REGRESSION | P=0.420 P=0.685 P=0.579 | P=0.065 P=0.521N P=0.099 |
|COCHRAN-ARMITAGE | P=0.578 | P=0.084 |
|FISHER EXACT | P=0.530N P=0.651 | P=0.500 P=0.126 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.0% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/10 (0%) 0/5 (0%) | 0/35 (0%) 0/28 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 565 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.165N P=0.339N P=0.363N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.042N* P=0.196N P=0.116N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.091N P=0.219N P=0.203N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.095N | (e) |
|FISHER EXACT | P=0.247N P=0.247N | (e) (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 1/49 (2%) 2/50 (4%) |
|ADJUSTED (b) | 11.5% 0.0% 0.0% | 0.0% 3.6% 6.7% |
|TERMINAL (d) | 3/26 (12%) 0/10 (0%) 0/5 (0%) | 0/35 (0%) 1/28 (4%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.208N P=0.329N P=0.510N | P=0.123 P=0.455 P=0.205 |
|INCIDENTAL TUMOR | P=0.208N P=0.329N P=0.510N | P=0.123 P=0.455 P=0.205 |
|LOGISTIC REGRESSION | P=0.208N P=0.329N P=0.510N | P=0.123 P=0.455 P=0.205 |
|COCHRAN-ARMITAGE | P=0.037N* | P=0.143 |
|FISHER EXACT | P=0.121N P=0.121N | P=0.495 P=0.247 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/49 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 13.5% 0.0% | 0.0% 0.0% 3.0% |
|TERMINAL (d) | 0/26 (0%) 0/10 (0%) 0/5 (0%) | 0/35 (0%) 0/28 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- 691 --- | --- --- 692 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.396 P=0.083 (e) | P=0.262 (e) P=0.483 |
|INCIDENTAL TUMOR | P=0.618N P=0.330 (e) | P=0.208 (e) P=0.419 |
|LOGISTIC REGRESSION | P=0.556 P=0.160 (e) | P=0.259 (e) P=0.485 |
|COCHRAN-ARMITAGE | P=0.669 | P=0.270 |
|FISHER EXACT | P=0.247 (e) | (e) P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.0% 31.4% | 0.0% 3.6% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/10 (0%) 1/5 (20%) | 0/35 (0%) 1/28 (4%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- 680 719 | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.015 * P=0.388 P=0.020 * | P=0.704 P=0.455 (e) |
|INCIDENTAL TUMOR | P=0.077 P=0.581 P=0.107 | P=0.704 P=0.455 (e) |
|LOGISTIC REGRESSION | P=0.036 * P=0.450 P=0.030 * | P=0.704 P=0.455 (e) |
|COCHRAN-ARMITAGE | P=0.142 | P=0.730 |
|FISHER EXACT | P=0.500 P=0.247 | P=0.495 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.0% 31.4% | 0.0% 3.6% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/10 (0%) 1/5 (20%) | 0/35 (0%) 1/28 (4%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- 680 719 | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.015 * P=0.388 P=0.020 * | P=0.704 P=0.455 (e) |
|INCIDENTAL TUMOR | P=0.077 P=0.581 P=0.107 | P=0.704 P=0.455 (e) |
|LOGISTIC REGRESSION | P=0.036 * P=0.450 P=0.030 * | P=0.704 P=0.455 (e) |
|COCHRAN-ARMITAGE | P=0.142 | P=0.730 |
|FISHER EXACT | P=0.500 P=0.247 | P=0.495 (e) |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 0/49 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 7.7% 0.0% 6.7% |
|TERMINAL (d) | 0/26 (0%) 0/10 (0%) 0/5 (0%) | 2/35 (6%) 0/28 (0%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 573 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.447N P=0.161N P=0.566N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.430N P=0.142N P=0.545N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.426N P=0.119N P=0.542N |
|COCHRAN-ARMITAGE | (e) | P=0.391N |
|FISHER EXACT | (e) (e) | P=0.125N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 4/50 (8%) 0/49 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 10.5% 0.0% 6.7% |
|TERMINAL (d) | 0/26 (0%) 0/10 (0%) 0/5 (0%) | 3/35 (9%) 0/28 (0%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 573 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.276N P=0.094N P=0.407N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.262N P=0.083N P=0.388N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.258N P=0.070N P=0.386N |
|COCHRAN-ARMITAGE | (e) | P=0.223N |
|FISHER EXACT | (e) (e) | P=0.061N P=0.339N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) | 15/50 (30%) 5/49 (10%) 2/50 (4%) |
|ADJUSTED (b) | 7.2% 0.0% 2.8% | 35.8% 16.7% 6.7% |
|TERMINAL (d) | 1/26 (4%) 0/10 (0%) 0/5 (0%) | 9/35 (26%) 4/28 (14%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | 715 --- 586 | 576 629 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.641 P=0.478N P=0.673 | P=0.001N** P=0.047N* P=0.003N** |
|INCIDENTAL TUMOR | P=0.374N P=0.285N P=0.523N | P<0.001N** P=0.023N* P=0.002N** |
|LOGISTIC REGRESSION | P=0.443N P=0.415N P=0.594N | P<0.001N** P=0.020N* P=0.001N** |
|COCHRAN-ARMITAGE | P=0.360N | P<0.001N** |
|FISHER EXACT | P=0.247N P=0.500N | P=0.013N* P<0.001N** |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) | 15/50 (30%) 5/49 (10%) 2/50 (4%) |
|ADJUSTED (b) | 7.2% 0.0% 2.8% | 35.8% 16.7% 6.7% |
|TERMINAL (d) | 1/26 (4%) 0/10 (0%) 0/5 (0%) | 9/35 (26%) 4/28 (14%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | 715 --- 586 | 576 629 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.641 P=0.478N P=0.673 | P=0.001N** P=0.047N* P=0.003N** |
|INCIDENTAL TUMOR | P=0.374N P=0.285N P=0.523N | P<0.001N** P=0.023N* P=0.002N** |
|LOGISTIC REGRESSION | P=0.443N P=0.415N P=0.594N | P<0.001N** P=0.020N* P=0.001N** |
|COCHRAN-ARMITAGE | P=0.360N | P<0.001N** |
|FISHER EXACT | P=0.247N P=0.500N | P=0.013N* P<0.001N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) | 18/50 (36%) 5/49 (10%) 4/50 (8%) |
|ADJUSTED (b) | 7.2% 0.0% 2.8% | 42.0% 16.7% 13.3% |
|TERMINAL (d) | 1/26 (4%) 0/10 (0%) 0/5 (0%) | 11/35 (31%) 4/28 (14%) 4/30 (13%) |
|FIRST INCIDENCE (DAYS) | 715 --- 586 | 573 629 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.641 P=0.478N P=0.673 | P=0.001N** P=0.014N* P=0.004N** |
|INCIDENTAL TUMOR | P=0.374N P=0.285N P=0.523N | P<0.001N** P=0.005N** P=0.003N** |
|LOGISTIC REGRESSION | P=0.443N P=0.415N P=0.594N | P<0.001N** P=0.004N** P=0.002N** |
|COCHRAN-ARMITAGE | P=0.360N | P<0.001N** |
|FISHER EXACT | P=0.247N P=0.500N | P=0.002N** P<0.001N** |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/50 (28%) 4/49 (8%) 4/50 (8%) | 21/50 (42%) 20/49 (41%) 19/50 (38%) |
|ADJUSTED (b) | 42.8% 28.2% 29.1% | 51.9% 59.9% 49.7% |
|TERMINAL (d) | 9/26 (35%) 2/9 (22%) 1/5 (20%) | 16/35 (46%) 15/28 (54%) 11/30 (37%) |
|FIRST INCIDENCE (DAYS) | 506 666 595 | 573 571 580 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.369N P=0.293N P=0.502N | P=0.458 P=0.331 P=0.510 |
|INCIDENTAL TUMOR | P=0.067N P=0.054N P=0.097N | P=0.461 P=0.436 P=0.511 |
|LOGISTIC REGRESSION | P=0.026N* P=0.053N P=0.038N* | P=0.514 P=0.448 P=0.577 |
|COCHRAN-ARMITAGE | P=0.004N** | P=0.380N |
|FISHER EXACT | P=0.010N** P=0.009N** | P=0.534N P=0.419N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/50 (30%) 4/49 (8%) 4/50 (8%) | 22/50 (44%) 20/49 (41%) 19/50 (38%) |
|ADJUSTED (b) | 43.9% 28.2% 29.1% | 54.4% 59.9% 49.7% |
|TERMINAL (d) | 9/26 (35%) 2/9 (22%) 1/5 (20%) | 17/35 (49%) 15/28 (54%) 11/30 (37%) |
|FIRST INCIDENCE (DAYS) | 480 666 595 | 573 571 580 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.271N P=0.220N P=0.392N | P=0.529 P=0.397 P=0.570N |
|INCIDENTAL TUMOR | P=0.034N* P=0.024N* P=0.049N* | P=0.540 P=0.510 P=0.578N |
|LOGISTIC REGRESSION | P=0.009N** P=0.024N* P=0.014N* | P=0.491N P=0.525 P=0.514N |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.306N |
|FISHER EXACT | P=0.005N** P=0.005N** | P=0.453N P=0.342N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 2/49 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 6.4% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/10 (0%) 0/5 (0%) | 0/35 (0%) 0/28 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- 687 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.640 P=0.210 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.601 P=0.265 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.644 P=0.213 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.668 |
|FISHER EXACT | (e) (e) | P=0.242 (e) |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 2/49 (4%) 0/50 (0%) |
|ADJUSTED (b) | 17.7% 6.7% 0.0% | 0.0% 7.1% 0.0% |
|TERMINAL (d) | 4/26 (15%) 0/10 (0%) 0/5 (0%) | 0/35 (0%) 2/28 (7%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 672 693 --- | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.159N P=0.398N P=0.304N | P=0.631 P=0.190 (e) |
|INCIDENTAL TUMOR | P=0.065N P=0.229N P=0.201N | P=0.631 P=0.190 (e) |
|LOGISTIC REGRESSION | P=0.067N P=0.265N P=0.162N | P=0.631 P=0.190 (e) |
|COCHRAN-ARMITAGE | P=0.011N* | P=0.668 |
|FISHER EXACT | P=0.102N P=0.028N* | P=0.242 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 1/50 (2%) 2/50 (4%) | 1/50 (2%) 2/49 (4%) 0/50 (0%) |
|ADJUSTED (b) | 21.5% 6.7% 6.7% | 2.8% 7.1% 0.0% |
|TERMINAL (d) | 5/26 (19%) 0/10 (0%) 0/5 (0%) | 0/35 (0%) 2/28 (7%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 672 693 565 | 698 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.495N P=0.314N P=0.652 | P=0.406N P=0.431 P=0.530N |
|INCIDENTAL TUMOR | P=0.201N P=0.175N P=0.384N | P=0.422N P=0.466 P=0.581N |
|LOGISTIC REGRESSION | P=0.177N P=0.198N P=0.288N | P=0.399N P=0.448 P=0.518N |
|COCHRAN-ARMITAGE | P=0.070N | P=0.361N |
|FISHER EXACT | P=0.056N P=0.134N | P=0.492 P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 3/50 (6%) | 1/50 (2%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 11.5% 2.5% 45.5% | 2.9% 2.6% 0.0% |
|TERMINAL (d) | 3/26 (12%) 0/10 (0%) 2/5 (40%) | 1/35 (3%) 0/28 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 519 692 | 729 (T) 609 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.093 P=0.591N P=0.049 * | P=0.368N P=0.716 P=0.531N |
|INCIDENTAL TUMOR | P=0.157 P=0.485N P=0.109 | P=0.338N P=0.749 P=0.531N |
|LOGISTIC REGRESSION | P=0.362 P=0.383N P=0.125 | P=0.332N P=0.766N P=0.531N |
|COCHRAN-ARMITAGE | P=0.594 | P=0.332N |
|FISHER EXACT | P=0.309N P=0.661N | P=0.747 P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 12/50 (24%) | 0/50 (0%) 0/49 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 17.7% 66.3% | 0.0% 0.0% 6.7% |
|TERMINAL (d) | 0/26 (0%) 1/10 (10%) 2/5 (40%) | 0/35 (0%) 0/28 (0%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | --- 664 490 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.041 * P<0.001 ** | P=0.085 (e) P=0.205 |
|INCIDENTAL TUMOR | P<0.001 ** P=0.105 P=0.001 ** | P=0.085 (e) P=0.205 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.066 P<0.001 ** | P=0.085 (e) P=0.205 |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.096 |
|FISHER EXACT | P=0.121 P<0.001 ** | (e) P=0.247 |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 45/50 (90%) 37/49 (76%) 39/50 (78%) | |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | |
|TERMINAL (d) | 26/26 (100%) 10/10 (100%) 5/5 (100%) | |
|FIRST INCIDENCE (DAYS) | 546 523 470 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.002 ** P<0.001 ** | |
|INCIDENTAL TUMOR | P=0.570N P=0.400 P=0.562 | |
|LOGISTIC REGRESSION | P=0.482N P=0.380 P=0.608N | |
|COCHRAN-ARMITAGE | P=0.080N | |
|FISHER EXACT | P=0.049N* P=0.086N | |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/50 (6%) 1/50 (2%) | 3/50 (6%) 3/48 (6%) 1/49 (2%) |
|ADJUSTED (b) | 17.7% 18.9% 20.0% | 8.6% 9.7% 3.4% |
|TERMINAL (d) | 4/26 (15%) 1/10 (10%) 1/5 (20%) | 3/35 (9%) 2/28 (7%) 1/29 (3%) |
|FIRST INCIDENCE (DAYS) | 657 608 729 (T) | 729 (T) 629 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.551N P=0.520 P=0.648N | P=0.311N P=0.560 P=0.374N |
|INCIDENTAL TUMOR | P=0.325N P=0.627N P=0.553N | P=0.296N P=0.574 P=0.374N |
|LOGISTIC REGRESSION | P=0.258N P=0.583N P=0.428N | P=0.298N P=0.595 P=0.374N |
|COCHRAN-ARMITAGE | P=0.070N | P=0.247N |
|FISHER EXACT | P=0.357N P=0.102N | P=0.641 P=0.316N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/48 (4%) 1/49 (2%) |
|ADJUSTED (b) | 7.7% 0.0% 0.0% | 2.9% 6.5% 3.4% |
|TERMINAL (d) | 2/26 (8%) 0/10 (0%) 0/5 (0%) | 1/35 (3%) 1/28 (4%) 1/29 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 729 (T) 684 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.314N P=0.465N P=0.636N | P=0.566 P=0.438 P=0.720 |
|INCIDENTAL TUMOR | P=0.314N P=0.465N P=0.636N | P=0.546 P=0.466 P=0.720 |
|LOGISTIC REGRESSION | P=0.314N P=0.465N P=0.636N | P=0.568 P=0.448 P=0.720 |
|COCHRAN-ARMITAGE | P=0.095N | P=0.615 |
|FISHER EXACT | P=0.247N P=0.247N | P=0.485 P=0.747 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 3/50 (6%) 1/50 (2%) | 4/50 (8%) 5/48 (10%) 2/49 (4%) |
|ADJUSTED (b) | 25.2% 18.9% 20.0% | 11.4% 15.8% 6.9% |
|TERMINAL (d) | 6/26 (23%) 1/10 (10%) 1/5 (20%) | 4/35 (11%) 3/28 (11%) 2/29 (7%) |
|FIRST INCIDENCE (DAYS) | 657 608 729 (T) | 729 (T) 629 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.379N P=0.610N P=0.508N | P=0.377N P=0.376 P=0.426N |
|INCIDENTAL TUMOR | P=0.197N P=0.458N P=0.421N | P=0.375N P=0.404 P=0.426N |
|LOGISTIC REGRESSION | P=0.135N P=0.388N P=0.295N | P=0.364N P=0.409 P=0.426N |
|COCHRAN-ARMITAGE | P=0.017N* | P=0.293N |
|FISHER EXACT | P=0.159N P=0.030N* | P=0.474 P=0.349N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 4/50 (8%) 0/50 (0%) | 0/50 (0%) 2/48 (4%) 0/49 (0%) |
|ADJUSTED (b) | 3.8% 18.3% 0.0% | 0.0% 6.0% 0.0% |
|TERMINAL (d) | 1/26 (4%) 0/10 (0%) 0/5 (0%) | 0/35 (0%) 1/28 (4%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 627 --- | --- 601 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.513 P=0.059 P=0.821N | P=0.629 P=0.200 (e) |
|INCIDENTAL TUMOR | P=0.307N P=0.168 P=0.821N | P=0.658 P=0.215 (e) |
|LOGISTIC REGRESSION | P=0.490N P=0.116 P=0.821N | P=0.666 P=0.233 (e) |
|COCHRAN-ARMITAGE | P=0.390N | P=0.663 |
|FISHER EXACT | P=0.181 P=0.500N | P=0.237 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 6/50 (12%) | 1/50 (2%) 2/48 (4%) 0/49 (0%) |
|ADJUSTED (b) | 3.8% 11.6% 31.9% | 2.9% 7.1% 0.0% |
|TERMINAL (d) | 1/26 (4%) 0/10 (0%) 0/5 (0%) | 1/35 (3%) 2/28 (7%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 671 569 | 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** P=0.244 P=0.005 ** | P=0.415N P=0.422 P=0.538N |
|INCIDENTAL TUMOR | P=0.076 P=0.489 P=0.129 | P=0.415N P=0.422 P=0.538N |
|LOGISTIC REGRESSION | P=0.017 * P=0.368 P=0.044 * | P=0.415N P=0.422 P=0.538N |
|COCHRAN-ARMITAGE | P=0.029 * | P=0.367N |
|FISHER EXACT | P=0.500 P=0.056 | P=0.485 P=0.505N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 6/50 (12%) 6/50 (12%) | 1/50 (2%) 4/48 (8%) 0/49 (0%) |
|ADJUSTED (b) | 7.7% 27.7% 31.9% | 2.9% 13.0% 0.0% |
|TERMINAL (d) | 2/26 (8%) 0/10 (0%) 0/5 (0%) | 1/35 (3%) 3/28 (11%) 0/29 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 627 569 | 729 (T) 601 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.006 ** P=0.020 * P=0.010 ** | P=0.459N P=0.124 P=0.538N |
|INCIDENTAL TUMOR | P=0.246 P=0.119 P=0.172 | P=0.439N P=0.131 P=0.538N |
|LOGISTIC REGRESSION | P=0.062 P=0.061 P=0.091 | P=0.440N P=0.142 P=0.538N |
|COCHRAN-ARMITAGE | P=0.114 | P=0.398N |
|FISHER EXACT | P=0.134 P=0.134 | P=0.168 P=0.505N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 8/50 (16%) 12/49 (24%) 9/50 (18%) |
|ADJUSTED (b) | | 20.9% 39.2% 30.0% |
|TERMINAL (d) | | 6/35 (17%) 10/28 (36%) 9/30 (30%) |
|FIRST INCIDENCE (DAYS) | | 614 523 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.300 P=0.101 P=0.359 |
|INCIDENTAL TUMOR | | P=0.346 P=0.142 P=0.389 |
|LOGISTIC REGRESSION | | P=0.323 P=0.138 P=0.380 |
|COCHRAN-ARMITAGE | | P=0.450 |
|FISHER EXACT | | P=0.212 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 28/50 (56%) 12/50 (24%) 14/50 (28%) | 20/50 (40%) 11/49 (22%) 14/50 (28%) |
|ADJUSTED (b) | 67.6% 67.3% 58.8% | 42.7% 30.5% 37.7% |
|TERMINAL (d) | 13/26 (50%) 6/10 (60%) 1/5 (20%) | 9/35 (26%) 5/28 (18%) 8/30 (27%) |
|FIRST INCIDENCE (DAYS) | 546 398 361 | 531 84 515 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.303 P=0.395N P=0.304 | P=0.268N P=0.164N P=0.323N |
|INCIDENTAL TUMOR | P=0.007N** P=0.018N* P=0.004N** | P=0.135N P=0.024N* P=0.188N |
|LOGISTIC REGRESSION | P=0.014N* P=0.011N* P=0.016N* | P=0.111N P=0.024N* P=0.154N |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.115N |
|FISHER EXACT | P=0.001N** P=0.004N** | P=0.047N* P=0.146N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 41/50 (82%) 44/50 (88%) | 35/50 (70%) 37/49 (76%) 31/50 (62%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 77.5% 92.4% 79.4% |
|TERMINAL (d) | 26/26 (100%) 10/10 (100%) 5/5 (100%) | 25/35 (71%) 25/28 (89%) 22/30 (73%) |
|FIRST INCIDENCE (DAYS) | 506 375 470 | 573 523 580 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.002 ** P<0.001 ** | P=0.443 P=0.073 P=0.507 |
|INCIDENTAL TUMOR | P=0.380N P=0.716 P=0.547N | P=0.493 P=0.128 P=0.539 |
|LOGISTIC REGRESSION | P=0.415N P=0.425 P=0.671N | P=0.547 P=0.110 P=0.576 |
|COCHRAN-ARMITAGE | P=0.135N | P=0.224N |
|FISHER EXACT | P=0.026N* P=0.134N | P=0.349 P=0.263N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 34/50 (68%) 16/50 (32%) 23/50 (46%) | 24/50 (48%) 15/49 (31%) 21/50 (42%) |
|ADJUSTED (b) | 76.8% 79.8% 85.9% | 51.5% 40.5% 53.1% |
|TERMINAL (d) | 16/26 (62%) 7/10 (70%) 3/5 (60%) | 13/35 (37%) 7/28 (25%) 12/30 (40%) |
|FIRST INCIDENCE (DAYS) | 480 398 361 | 531 84 515 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.027 * P=0.499N P=0.033 * | P=0.530 P=0.222N P=0.541 |
|INCIDENTAL TUMOR | P=0.049N* P=0.008N** P=0.024N* | P=0.395N P=0.039N* P=0.451N |
|LOGISTIC REGRESSION | P=0.085N P=0.006N** P=0.068N | P=0.351N P=0.045N* P=0.410N |
|COCHRAN-ARMITAGE | P=0.018N* | P=0.305N |
|FISHER EXACT | P<0.001N** P=0.021N* | P=0.059N P=0.344N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05031 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- MERCURIC CHLORIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5MG/KG 5 MG/KG | CONTROL 2.5MG/KG 5.0MG/KG |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 42/50 (84%) 45/50 (90%) | 46/50 (92%) 42/49 (86%) 39/50 (78%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 92.0% 97.7% 90.7% |
|TERMINAL (d) | 26/26 (100%) 10/10 (100%) 5/5 (100%) | 31/35 (89%) 27/28 (96%) 26/30 (87%) |
|FIRST INCIDENCE (DAYS) | 480 375 361 | 531 84 515 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.002 ** P<0.001 ** | P=0.498N P=0.265 P=0.517N |
|INCIDENTAL TUMOR | P=0.270N P=0.669N P=0.378N | P=0.215N P=0.494N P=0.303N |
|LOGISTIC REGRESSION | P=0.183N P=0.669N P=0.382N | P=0.180N P=0.510N P=0.242N |
|COCHRAN-ARMITAGE | P=0.114N | P=0.033N* |
|FISHER EXACT | P=0.015N* P=0.102N | P=0.251N P=0.045N* |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).