TDMS Study 05031-02 Pathology Tables
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
Facility: International Research and Development Corp.
Chemical CAS #: 7487-94-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 6| 3| 7| 5| 3| 3| 6| 3| 9| 3| 3| 3| 4| 3| 6| 3| 3| 6| 6| 3| 2| 3|
| 2| 3| 1| 0| 3| 6| 5| 4| 4| 0| 3| 8| 3| 3| 2| 3| 4| 0| 2| 3| 0| 6| 3| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus, Multiple | X X X X X X X X X X |
Cytoplasmic Alteration, Focal | 2 1 1 |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous | 2 2 1 2 1 2 |
Necrosis, Acute | 2|
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 3|
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 1 2 2 1 2 2|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia | 1 |
Inflammation, Acute | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Tongue | + |
Hemorrhage, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + |
Aorta, Inflammation, Chronic | |
Mesenteric Artery, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 6| 3| 7| 5| 3| 3| 6| 3| 9| 3| 3| 3| 4| 3| 6| 3| 3| 6| 6| 3| 2| 3|
| 2| 3| 1| 0| 3| 6| 5| 4| 4| 0| 3| 8| 3| 3| 2| 3| 4| 0| 2| 3| 0| 6| 3| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 1 1 2 1 1 1 2 1 1 1 1 1 2 |
Coronary Artery, Inflammation, | |
Chronic | 2 |
Endocardium, Fibrosis | |
Epicardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | |
Hyperplasia, Focal | 1 1 |
Hypertrophy, Focal | 1 1 2|
Vacuolization Cytoplasmic, Focal | 1 2 2 1 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + +|
Cyst | |
Hyperplasia, Focal | 1 2|
Bilateral, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 2 2|
Pars Distalis, Cyst | 1 2 1 2 3 |
Pars Distalis, Ectasia | |
Pars Distalis, Hyperplasia | 1 2 2 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + M + + M + + + + + + + + M + +|
Inflammation, Chronic | |
Duct, Ectasia | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Periovarian Tissue, Cyst | |
Follicle, Cyst | |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 6| 3| 7| 5| 3| 3| 6| 3| 9| 3| 3| 3| 4| 3| 6| 3| 3| 6| 6| 3| 2| 3|
| 2| 3| 1| 0| 3| 6| 5| 4| 4| 0| 3| 8| 3| 3| 2| 3| 4| 0| 2| 3| 0| 6| 3| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + + + + + + + + M + +|
Mandibular, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + M + +|
Ectasia | 1 1 |
Hyperplasia, Plasma Cell | |
Inflammation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | 2 |
Capsule, Fibrosis, Focal | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M +|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Galactocele | 2 3|
Hyperplasia | 1 |
Duct, Ectasia | 3 2 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Inflammation, Chronic | 1 1 |
Inflammation, Granulomatous | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 5| 6| 7| 7| 4| 7| 6| 7| 7| 7| 6| 7| 4| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 6| 3| 7| 5| 3| 3| 6| 3| 9| 3| 3| 3| 4| 3| 6| 3| 3| 6| 6| 3| 2| 3|
| 2| 3| 1| 0| 3| 6| 5| 4| 4| 0| 3| 8| 3| 3| 2| 3| 4| 0| 2| 3| 0| 6| 3| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Mucosa, Cyst | 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Hemorrhage | |
Lens, Cataract | 3 2 |
Lens, Degeneration | 4 |
Retina, Degeneration | 4 3 4 |
Sclera, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Nephropathy | 1 1 1 1 1 1 2 1 1 1 1 2 1 3 1 2 1 1 1 2 1|
Pigmentation | 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 7| 6| 6| 6| 5| 7| 4| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 6| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 5| 5| 4| 7| 2| 6| 6| 2| 3| 3| 3| 3| 7| 6| 6| 6| 5| 1| 3|
| 0| 2| 1| 3| 4| 4| 7| 6| 1| 2| 9| 0| 0| 9| 4| 3| 4| 2| 3| 0| 0| 0| 9| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus, Multiple | X X X X X X X X X X X|
Cytoplasmic Alteration, Focal | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | |
Inflammation, Granulomatous | 1 3 1 2 2 1 1 |
Necrosis, Acute | |
Vacuolization Cytoplasmic, Focal | 3 |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 1 1 1 1 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hyperplasia | 2 2 2 1 |
Inflammation, Acute | 2 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 1 1 |
__________________________________________________________________________|
Tongue | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + |
Aorta, Inflammation, Chronic | 2 |
Mesenteric Artery, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 7| 6| 6| 6| 5| 7| 4| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 6| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 5| 5| 4| 7| 2| 6| 6| 2| 3| 3| 3| 3| 7| 6| 6| 6| 5| 1| 3|
| 0| 2| 1| 3| 4| 4| 7| 6| 1| 2| 9| 0| 0| 9| 4| 3| 4| 2| 3| 0| 0| 0| 9| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 2 1 1 2 1 1 1 1|
Coronary Artery, Inflammation, | |
Chronic | |
Endocardium, Fibrosis | 3 |
Epicardium, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + M + + +|
Accessory Adrenal Cortical Nodule | 1 |
Degeneration, Fatty | 1 |
Hyperplasia, Focal | 1 |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Focal | 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + +|
Cyst | 2 |
Hyperplasia, Focal | 2 |
Bilateral, Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 1 2 |
Pars Distalis, Cyst | 2 1 3 1 1 |
Pars Distalis, Ectasia | |
Pars Distalis, Hyperplasia | 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Bilateral, Periovarian Tissue, Cyst | X |
Follicle, Cyst | 1 |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 7| 6| 6| 6| 5| 7| 4| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 6| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 5| 5| 4| 7| 2| 6| 6| 2| 3| 3| 3| 3| 7| 6| 6| 6| 5| 1| 3|
| 0| 2| 1| 3| 4| 4| 7| 6| 1| 2| 9| 0| 0| 9| 4| 3| 4| 2| 3| 0| 0| 0| 9| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Cyst | 4 |
Endometrium, Hyperplasia, Cystic | 3 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + + + + + + M + + +|
Mandibular, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Plasma Cell | |
Inflammation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Granulocytic | |
Capsule, Fibrosis, Focal | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Galactocele | |
Hyperplasia | 1 2 2 |
Duct, Ectasia | 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Congestion | 1 1 2 |
Hemorrhage | |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous | 1 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 7| 6| 6| 6| 5| 7| 4| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 6| 6| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 5| 5| 4| 7| 2| 6| 6| 2| 3| 3| 3| 3| 7| 6| 6| 6| 5| 1| 3|
| 0| 2| 1| 3| 4| 4| 7| 6| 1| 2| 9| 0| 0| 9| 4| 3| 4| 2| 3| 0| 0| 0| 9| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
Mucosa, Cyst | |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | 3 2 |
Lens, Cataract | 2 |
Lens, Degeneration | |
Retina, Degeneration | 4 |
Sclera, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Nephropathy | 3 2 1 1 2 3 2 1 1 2 1 2 3 2 2 2 1 2|
Pigmentation | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 0| 2| 4| 2| 3| 4| 2| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 50 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Angiectasis | | 1 1.0|
Basophilic Focus, Multiple | X X X X X X | 27 |
Cytoplasmic Alteration, Focal | | 3 1.3|
Hepatodiaphragmatic Nodule | | 8 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Granulomatous | 2 1 2 1 1 | 18 1.6|
Necrosis, Acute | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 2 2.5|
Bile Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis, Focal | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Atrophy, Focal | 2 3 1 1 | 20 1.4|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Hemorrhage, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Edema | | 1 3.0|
Hyperplasia | | 5 1.6|
Inflammation, Acute | | 2 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Necrosis | | 3 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hemorrhage, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 0| 2| 4| 2| 3| 4| 2| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 15 |
Aorta, Inflammation, Chronic | | 1 2.0|
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Inflammation, Chronic | 1 1 1 1 | 31 1.2|
Coronary Artery, Inflammation, | | |
Chronic | | 1 2.0|
Endocardium, Fibrosis | | 1 3.0|
Epicardium, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 49 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Degeneration, Fatty | | 1 1.0|
Hyperplasia, Focal | 1 2 | 5 1.2|
Hypertrophy, Focal | | 3 1.3|
Vacuolization Cytoplasmic, Focal | 1 | 10 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 48 |
Cyst | | 1 2.0|
Hyperplasia, Focal | 1 | 4 1.5|
Bilateral, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Hyperplasia, Focal | 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 47 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Angiectasis | | 8 2.0|
Pars Distalis, Cyst | 2 2 2 | 13 1.8|
Pars Distalis, Ectasia | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | 1 1 1 1 1 | 15 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 0| 2| 4| 2| 3| 4| 2| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 46 |
Inflammation, Chronic | | 1 1.0|
Duct, Ectasia | | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Bilateral, Periovarian Tissue, Cyst | | 1 |
Follicle, Cyst | | 1 1.0|
Periovarian Tissue, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Hyperplasia, Cystic | | 1 3.0|
Endometrium, Cyst | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 1 | 3 2.0|
__________________________________________________________________________|____________|
Vagina | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Myelofibrosis | 1 1 | 4 1.8|
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + M M | 44 |
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M M | 40 |
Ectasia | | 2 1.0|
Hyperplasia, Plasma Cell | 1 | 1 1.0|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 2.0|
Capsule, Fibrosis, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 48 |
Congestion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 50 |
Cyst | | 1 3.0|
Galactocele | | 2 2.5|
Hyperplasia | | 4 1.5|
Duct, Ectasia | 1 1 1 1 2 | 11 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 0| 2| 4| 2| 3| 4| 2| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Osteopetrosis | 3 | 2 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Inflammation, Chronic | | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | 1 1 1 2 | 7 1.3|
Hemorrhage | 1 | 2 1.0|
Inflammation, Chronic | | 3 1.0|
Inflammation, Granulomatous | | 2 1.5|
Alveolar Epithelium, Hyperplasia | 3 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 1.0|
__________________________________________________________________________|____________|
Nose | + M + + + + + + + + | 49 |
Autolysis | | 1 1.0|
Mucosa, Cyst | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 2 1.5|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Hemorrhage | | 2 2.5|
Lens, Cataract | | 3 2.3|
Lens, Degeneration | | 1 4.0|
Retina, Degeneration | | 4 3.8|
Sclera, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Autolysis | | 1 2.0|
Nephropathy | 1 1 2 1 2 2 1 1 2 1 | 49 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 4| 0| 2| 4| 2| 3| 4| 2| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pigmentation | | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 0| 4| 4| 4| 7| 7| 6| 7| 7| 5| 4| 7| 7| 7| 6| 7| 4| 7| 6| 7|
DAY ON TEST | 3| 3| 1| 3| 6| 0| 6| 6| 6| 3| 3| 1| 3| 3| 9| 6| 3| 3| 3| 0| 3| 6| 3| 0| 3|
| 3| 3| 7| 4| 0| 7| 0| 0| 0| 3| 4| 4| 2| 3| 5| 0| 2| 2| 4| 1| 4| 0| 4| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X|
Congestion | |
Cytoplasmic Alteration, Focal | 2 |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | |
Inflammation, Granulomatous | 2 1 2 2 1 2 3 2 2 2|
Necrosis, Acute | |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 1 |
Hepatocyte, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 1 2 2 1 2 |
Autolysis | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | 2 |
Necrosis | 1 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 0| 4| 4| 4| 7| 7| 6| 7| 7| 5| 4| 7| 7| 7| 6| 7| 4| 7| 6| 7|
DAY ON TEST | 3| 3| 1| 3| 6| 0| 6| 6| 6| 3| 3| 1| 3| 3| 9| 6| 3| 3| 3| 0| 3| 6| 3| 0| 3|
| 3| 3| 7| 4| 0| 7| 0| 0| 0| 3| 4| 4| 2| 3| 5| 0| 2| 2| 4| 1| 4| 0| 4| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1|
Atrium Left, Thrombosis | 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Congestion | 3 |
Degeneration, Fatty | 2 |
Hyperplasia, Focal | 1 1 1 2 1 1 2 1|
Hypertrophy, Focal | 1 1 |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 3 |
Pars Distalis, Cyst | 1 2 3 3 1|
Pars Distalis, Ectasia | 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 1 1 1 |
Pars Distalis, Hypertrophy | |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + I + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M +|
Hyperplasia | |
Inflammation, Acute | 3 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 0| 4| 4| 4| 7| 7| 6| 7| 7| 5| 4| 7| 7| 7| 6| 7| 4| 7| 6| 7|
DAY ON TEST | 3| 3| 1| 3| 6| 0| 6| 6| 6| 3| 3| 1| 3| 3| 9| 6| 3| 3| 3| 0| 3| 6| 3| 0| 3|
| 3| 3| 7| 4| 0| 7| 0| 0| 0| 3| 4| 4| 2| 3| 5| 0| 2| 2| 4| 1| 4| 0| 4| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hemorrhage | 1 |
Inflammation, Acute | |
Endometrium, Cyst | 3 2|
Endometrium, Hyperplasia, Cystic | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Hypoplasia | |
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + + + + + + + + + +|
Mandibular, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thymus | I I + I + + + + + + + + + + + + M +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M +|
Galactocele | 3 |
Hyperplasia | 1 |
Inflammation, Acute | |
Duct, Ectasia | 2 2 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Demyelination, Focal | |
Hemorrhage | |
Hydrocephalus | 2 |
White Matter, Vacuolization | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 0| 4| 4| 4| 7| 7| 6| 7| 7| 5| 4| 7| 7| 7| 6| 7| 4| 7| 6| 7|
DAY ON TEST | 3| 3| 1| 3| 6| 0| 6| 6| 6| 3| 3| 1| 3| 3| 9| 6| 3| 3| 3| 0| 3| 6| 3| 0| 3|
| 3| 3| 7| 4| 0| 7| 0| 0| 0| 3| 4| 4| 2| 3| 5| 0| 2| 2| 4| 1| 4| 0| 4| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Cytoplasmic | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Congestion | 1 1 1 1 2 |
Ectopic Tissue | X |
Hemorrhage | 2 |
Inflammation, Chronic | |
Inflammation, Focal | |
Alveolar Epithelium, Hyperplasia | 1 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Fungus | X |
Mucosa, Inflammation, Acute | |
Mucosa, Inflammation, Chronic Active | 2 4 |
Mucosa, Mineralization, Focal | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Respiratory Epithelium, Degeneration | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Hemorrhage | 3|
Lens, Cataract | 3|
Retina, Degeneration | 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Congestion | |
Degeneration, Hyaline | |
Karyomegaly | 1 |
Mineralization | |
Nephropathy | 1 1 2 1 1 1 1 1 1 2 2 2 2 1 1 1 2|
Pigmentation | 2 |
Renal Tubule, Hyperplasia, Oncocytic | 2 |
Renal Tubule, Hypertrophy | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 5| 7| 4| 6| 7| 0| 6| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 5| 7| 4|
DAY ON TEST | 8| 3| 7| 3| 3| 2| 3| 6| 4| 3| 8| 8| 2| 3| 3| 5| 0| 3| 6| 3| 7| 3| 5| 3| 6|
| 2| 2| 1| 3| 2| 3| 2| 0| 7| 4| 4| 7| 9| 4| 3| 6| 8| 4| 0| 7| 7| 1| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + M + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 |
Basophilic Focus, Multiple | X X X X X X X X X X |
Congestion | 2 2 2 |
Cytoplasmic Alteration, Focal | 3 2 |
Degeneration, Fatty | 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | |
Inflammation, Granulomatous | 2 1 1 1 1 1 2 2 2 |
Necrosis, Acute | |
Vacuolization Cytoplasmic, Focal | 2 |
Bile Duct, Hyperplasia | 1 |
Hepatocyte, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Atrophy, Focal | 2 1 1 1 1 1 2 |
Autolysis | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 1 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Inflammation, Chronic | |
Necrosis | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 5| 7| 4| 6| 7| 0| 6| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 5| 7| 4|
DAY ON TEST | 8| 3| 7| 3| 3| 2| 3| 6| 4| 3| 8| 8| 2| 3| 3| 5| 0| 3| 6| 3| 7| 3| 5| 3| 6|
| 2| 2| 1| 3| 2| 3| 2| 0| 7| 4| 4| 7| 9| 4| 3| 6| 8| 4| 0| 7| 7| 1| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 2 |
Atrium Left, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 3 |
Congestion | 3 2 2 4 |
Degeneration, Fatty | |
Hyperplasia, Focal | 2 1 1 |
Hypertrophy, Focal | 1 |
Necrosis, Focal | 1 |
Vacuolization Cytoplasmic, Focal | 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 1 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 2 2 2 |
Pars Distalis, Cyst | 2 2 1 2 2 1 2 2 |
Pars Distalis, Ectasia | |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 2 1 1 2 1 2 |
Pars Distalis, Hypertrophy | |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + |
Hyperplasia | 1 |
Inflammation, Acute | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 5| 7| 4| 6| 7| 0| 6| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 5| 7| 4|
DAY ON TEST | 8| 3| 7| 3| 3| 2| 3| 6| 4| 3| 8| 8| 2| 3| 3| 5| 0| 3| 6| 3| 7| 3| 5| 3| 6|
| 2| 2| 1| 3| 2| 3| 2| 0| 7| 4| 4| 7| 9| 4| 3| 6| 8| 4| 0| 7| 7| 1| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Ectasia | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Follicle, Cyst | 2 X 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + |
Dilatation | |
Hemorrhage | |
Inflammation, Acute | |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
Hypoplasia | |
Myelofibrosis | 1 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Mandibular, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + I + + + + + + |
Cyst | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Galactocele | 3 |
Hyperplasia | 1 2 |
Inflammation, Acute | 2 |
Duct, Ectasia | 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Demyelination, Focal | 2 |
Hemorrhage | 2 |
Hydrocephalus | |
White Matter, Vacuolization | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 5| 7| 4| 6| 7| 0| 6| 7| 7| 7| 6| 7| 7| 4| 4| 2| 7| 5| 7| 4|
DAY ON TEST | 8| 3| 7| 3| 3| 2| 3| 6| 4| 3| 8| 8| 2| 3| 3| 5| 0| 3| 6| 3| 7| 3| 5| 3| 6|
| 2| 2| 1| 3| 2| 3| 2| 0| 7| 4| 4| 7| 9| 4| 3| 6| 8| 4| 0| 7| 7| 1| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Cytoplasmic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 2 3 1 2 1 1 1 2 |
Ectopic Tissue | |
Hemorrhage | 2 |
Inflammation, Chronic | 1 |
Inflammation, Focal | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + |
Fungus | X X |
Mucosa, Inflammation, Acute | |
Mucosa, Inflammation, Chronic Active | 2 3 |
Mucosa, Mineralization, Focal | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 1 |
Respiratory Epithelium, Degeneration | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Granulomatous | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Hemorrhage | |
Lens, Cataract | 3 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 2 1 |
Degeneration, Hyaline | 2 |
Karyomegaly | 2 1 1 |
Mineralization | 1 1 |
Nephropathy | 1 1 1 1 3 1 1 3 1 1 1 2 1 2 2 1 2 |
Pigmentation | |
Renal Tubule, Hyperplasia, Oncocytic | |
Renal Tubule, Hypertrophy | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 2| 6| 7| 7| 5| 7| 6| 7| 4| 7| | |
DAY ON TEST | 8| 8| 3| 1| 6| 3| 2| 2| 6| 3| | |
| 5| 4| 3| 7| 5| 2| 9| 9| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 49 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 46 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 49 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 49 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 49 |
Autolysis | | 2 3.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 49 |
Angiectasis | | 1 1.0|
Basophilic Focus, Multiple | X X X X | 28 |
Congestion | 2 | 4 2.0|
Cytoplasmic Alteration, Focal | 1 | 4 2.0|
Degeneration, Fatty | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 4 |
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Granulomatous | 1 1 2 2 | 23 1.7|
Necrosis, Acute | 1 | 1 1.0|
Vacuolization Cytoplasmic, Focal | 1 2 | 3 1.7|
Bile Duct, Hyperplasia | 1 1 | 4 1.0|
Hepatocyte, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 49 |
Atrophy, Focal | 1 1 1 | 17 1.4|
Autolysis | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 49 |
Hyperplasia | | 5 1.4|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 2| 6| 7| 7| 5| 7| 6| 7| 4| 7| | |
DAY ON TEST | 8| 8| 3| 1| 6| 3| 2| 2| 6| 3| | |
| 5| 4| 3| 7| 5| 2| 9| 9| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 49 |
Autolysis | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 18 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 49 |
Inflammation, Chronic | 1 2 1 1 2 1 1 | 38 1.2|
Atrium Left, Thrombosis | 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 49 |
Angiectasis | 2 2 2 | 5 2.0|
Congestion | | 5 2.8|
Degeneration, Fatty | 3 | 2 2.5|
Hyperplasia, Focal | | 11 1.3|
Hypertrophy, Focal | | 3 1.0|
Necrosis, Focal | | 1 1.0|
Vacuolization Cytoplasmic, Focal | 1 3 | 7 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Hyperplasia, Focal | | 8 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + | 49 |
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 49 |
Pars Distalis, Angiectasis | 2 | 7 2.1|
Pars Distalis, Cyst | 1 3 2 | 16 1.9|
Pars Distalis, Ectasia | | 1 2.0|
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia | 1 | 10 1.3|
Pars Distalis, Hypertrophy | 1 | 1 1.0|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 48 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 2| 6| 7| 7| 5| 7| 6| 7| 4| 7| | |
DAY ON TEST | 8| 8| 3| 1| 6| 3| 2| 2| 6| 3| | |
| 5| 4| 3| 7| 5| 2| 9| 9| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + M | 46 |
Hyperplasia | | 1 1.0|
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic | 1 1 | 2 1.0|
Duct, Ectasia | | 2 1.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 49 |
Hemorrhage | | 1 2.0|
Follicle, Cyst | | 3 1.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 49 |
Dilatation | | 1 2.0|
Hemorrhage | | 1 1.0|
Inflammation, Acute | 1 | 1 1.0|
Endometrium, Cyst | | 2 2.5|
Endometrium, Hyperplasia, Cystic | | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 49 |
Hypoplasia | 1 | 1 1.0|
Myelofibrosis | | 1 1.0|
Myeloid Cell, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 48 |
Mandibular, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 28 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Thymus | + + + I + + + + + | 43 |
Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 48 |
Galactocele | | 2 3.0|
Hyperplasia | | 3 1.3|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 2| 6| 7| 7| 5| 7| 6| 7| 4| 7| | |
DAY ON TEST | 8| 8| 3| 1| 6| 3| 2| 2| 6| 3| | |
| 5| 4| 3| 7| 5| 2| 9| 9| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Duct, Ectasia | 2 | 8 1.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 49 |
Inflammation, Acute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 49 |
Inflammation, Acute | 2 | 1 2.0|
Osteopetrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 49 |
Demyelination, Focal | | 1 2.0|
Hemorrhage | | 1 2.0|
Hydrocephalus | | 1 2.0|
White Matter, Vacuolization | | |
Cytoplasmic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 49 |
Congestion | 1 2 | 16 1.5|
Ectopic Tissue | | 1 |
Hemorrhage | | 2 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 | 2 1.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 49 |
Fungus | | 3 |
Mucosa, Inflammation, Acute | 1 | 1 1.0|
Mucosa, Inflammation, Chronic Active | | 4 2.8|
Mucosa, Mineralization, Focal | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 2 1.0|
Respiratory Epithelium, Degeneration | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 2| 6| 7| 7| 5| 7| 6| 7| 4| 7| | |
DAY ON TEST | 8| 8| 3| 1| 6| 3| 2| 2| 6| 3| | |
| 5| 4| 3| 7| 5| 2| 9| 9| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 49 |
Inflammation, Granulomatous | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Hemorrhage | | 1 3.0|
Lens, Cataract | 2 | 3 2.7|
Retina, Degeneration | | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 49 |
Congestion | | 3 1.7|
Degeneration, Hyaline | | 1 2.0|
Karyomegaly | | 4 1.3|
Mineralization | | 2 1.0|
Nephropathy | 1 1 3 2 1 2 1 1 2 | 43 1.4|
Pigmentation | | 1 2.0|
Renal Tubule, Hyperplasia, Oncocytic | | 1 2.0|
Renal Tubule, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + I + + + + + + + | 48 |
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 4| 7| 6| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 3| 6| 3| 6| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 6|
| 2| 3| 2| 4| 0| 4| 5| 0| 2| 9| 3| 4| 4| 4| 2| 4| 4| 0| 2| 9| 4| 0| 3| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 4 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 4 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 4 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X |
Congestion | |
Cytoplasmic Alteration, Focal | 3 |
Degeneration, Fatty | |
Ectasia, Focal | |
Eosinophilic Focus | |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Granulomatous | 2 2 2 1 2 1 1 2 1 |
Mixed Cell Focus | X |
Mixed Cell Focus, Multiple | X |
Necrosis, Acute | |
Vacuolization Cytoplasmic, Focal | 3 2 3 |
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Atrophy, Focal | 1 1 1 2 2 1 1 1 1 |
Autolysis | |
Cytoplasmic Alteration, Focal | 2 |
Ectopic Liver | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 4| 7| 6| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 3| 6| 3| 6| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 6|
| 2| 3| 2| 4| 0| 4| 5| 0| 2| 9| 3| 4| 4| 4| 2| 4| 4| 0| 2| 9| 4| 0| 3| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Cytoplasmic Alteration, Focal | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 1 2 2 1 |
Inflammation, Acute | 1 1 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Necrosis | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 |
Atrium Left, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Hyperplasia, Focal | 1 1 1 1 |
Hypertrophy, Focal | 1 1 1 |
Vacuolization Cytoplasmic, Focal | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + I + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + M + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 1 2 1 2 |
Pars Distalis, Hypertrophy | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + |
C-Cell, Hyperplasia | 1 1 |
Follicle, Cyst | 1 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + I + + + + + M + + M + + |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 4| 7| 6| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 3| 6| 3| 6| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 6|
| 2| 3| 2| 4| 0| 4| 5| 0| 2| 9| 3| 4| 4| 4| 2| 4| 4| 0| 2| 9| 4| 0| 3| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + |
Follicle, Cyst | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Cyst | 2 |
Hemorrhage | |
Cervix, Cyst | 2 |
Endometrium, Cyst | 1 2 |
Endometrium, Hyperplasia, Cystic | 1 1 1 |
__________________________________________________________________________|
Vagina | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + + + + + + + + + + + |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
Granulocytic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + |
Cyst | 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
Galactocele | 3 |
Hyperplasia | 2 |
Inflammation, Acute | |
Duct, Ectasia | 1 1 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
Osteopetrosis | 2 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Hydrocephalus | 2 |
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 4| 7| 6| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 3| 6| 3| 6| 0| 3| 2| 1| 3| 3| 3| 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 6|
| 2| 3| 2| 4| 0| 4| 5| 0| 2| 9| 3| 4| 4| 4| 2| 4| 4| 0| 2| 9| 4| 0| 3| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 1 1 1 2 1 1 1 1 1 |
Hemorrhage | |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous | |
Alveolar Epithelium, Hyperplasia | 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Foreign Body | 1 |
Fungus | X |
Mucosa, Inflammation, Acute | 1 |
Mucosa, Inflammation, Chronic Active | 1 2 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Cyst | 2 |
Hemorrhage, Focal | |
Nephropathy | 2 1 1 1 2 2 1 1 2 2 2 1 2 3 1 2 1 1 |
Pigmentation | 2 |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 0| 7| 5| 7| 6| 7| 7| 5| 4| 4| 5| 7| 7| 7| 5| 7| 5| 7| 6| 4|
DAY ON TEST | 3| 8| 3| 3| 2| 8| 3| 9| 3| 3| 3| 2| 8| 6| 6| 1| 3| 3| 3| 1| 3| 8| 3| 3| 6|
| 2| 1| 3| 3| 3| 7| 3| 3| 2| 1| 3| 9| 0| 0| 0| 5| 3| 3| 4| 8| 2| 6| 2| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X |
Congestion | |
Cytoplasmic Alteration, Focal | |
Degeneration, Fatty | 2 3 |
Ectasia, Focal | 2 |
Eosinophilic Focus | X |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Granulomatous | 2 1 1 2 1 1 1 1 |
Mixed Cell Focus | |
Mixed Cell Focus, Multiple | |
Necrosis, Acute | 1 |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Atrophy, Focal | 1 1 1 1 1 1 1 1 |
Autolysis | 3 |
Cytoplasmic Alteration, Focal | |
Ectopic Liver | X |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 0| 7| 5| 7| 6| 7| 7| 5| 4| 4| 5| 7| 7| 7| 5| 7| 5| 7| 6| 4|
DAY ON TEST | 3| 8| 3| 3| 2| 8| 3| 9| 3| 3| 3| 2| 8| 6| 6| 1| 3| 3| 3| 1| 3| 8| 3| 3| 6|
| 2| 1| 3| 3| 3| 7| 3| 3| 2| 1| 3| 9| 0| 0| 0| 5| 3| 3| 4| 8| 2| 6| 2| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + |
Cytoplasmic Alteration, Focal | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 1 1 2 2 2 1 3 3 1 |
Inflammation, Acute | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Necrosis | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 |
Atrium Left, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 3 |
Hyperplasia, Focal | 1 1 2 1 1 |
Hypertrophy, Focal | 1 |
Vacuolization Cytoplasmic, Focal | 1 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 3 1 |
Pars Distalis, Cyst | 1 1 1 |
Pars Distalis, Hyperplasia | 1 2 1 1 |
Pars Distalis, Hypertrophy | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 3 1 |
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 0| 7| 5| 7| 6| 7| 7| 5| 4| 4| 5| 7| 7| 7| 5| 7| 5| 7| 6| 4|
DAY ON TEST | 3| 8| 3| 3| 2| 8| 3| 9| 3| 3| 3| 2| 8| 6| 6| 1| 3| 3| 3| 1| 3| 8| 3| 3| 6|
| 2| 1| 3| 3| 3| 7| 3| 3| 2| 1| 3| 9| 0| 0| 0| 5| 3| 3| 4| 8| 2| 6| 2| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | |
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + |
Follicle, Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Hemorrhage | 3 |
Cervix, Cyst | |
Endometrium, Cyst | 1 2 |
Endometrium, Hyperplasia, Cystic | 1 1 1 |
__________________________________________________________________________|
Vagina | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Congestion | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Re Cell | 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + I + + + + |
Cyst | 1 1 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Galactocele | |
Hyperplasia | |
Inflammation, Acute | 1 |
Duct, Ectasia | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Hydrocephalus | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 0| 7| 5| 7| 6| 7| 7| 5| 4| 4| 5| 7| 7| 7| 5| 7| 5| 7| 6| 4|
DAY ON TEST | 3| 8| 3| 3| 2| 8| 3| 9| 3| 3| 3| 2| 8| 6| 6| 1| 3| 3| 3| 1| 3| 8| 3| 3| 6|
| 2| 1| 3| 3| 3| 7| 3| 3| 2| 1| 3| 9| 0| 0| 0| 5| 3| 3| 4| 8| 2| 6| 2| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
5.0MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 3 1 2 4 1 |
Hemorrhage | 1 |
Inflammation, Chronic | 1 1 2 |
Inflammation, Granulomatous | 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 3 |
Foreign Body | 1 1 |
Fungus | X |
Mucosa, Inflammation, Acute | 1 3 |
Mucosa, Inflammation, Chronic Active | 4 1 2 2 1 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Cyst | |
Hemorrhage, Focal | |
Nephropathy | 1 1 2 1 1 3 1 3 1 1 1 1 1 2 3 1 2 |
Pigmentation | 2 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 4| 4| 1| 6| 4| 7| 7| | |
DAY ON TEST | 9| 9| 6| 2| 6| 0| 2| 6| 3| 3| | |
| 2| 2| 0| 8| 0| 6| 6| 0| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 50 |
Inflammation, Chronic | 3 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 50 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 50 |
Autolysis | 2 | 3 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 50 |
Autolysis | 3 | 3 3.7|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + | 50 |
Autolysis | 3 | 4 3.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + | 50 |
Angiectasis | | 1 1.0|
Basophilic Focus, Multiple | X X | 32 |
Clear Cell Focus | | 9 |
Congestion | 2 | 1 2.0|
Cytoplasmic Alteration, Focal | | 1 3.0|
Degeneration, Fatty | | 2 2.5|
Ectasia, Focal | | 1 2.0|
Eosinophilic Focus | | 1 |
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | | 8 |
Inflammation, Granulomatous | | 17 1.4|
Mixed Cell Focus | | 1 |
Mixed Cell Focus, Multiple | | 1 |
Necrosis, Acute | 1 | 2 1.0|
Vacuolization Cytoplasmic, Focal | | 3 2.7|
Bile Duct, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 50 |
Atrophy, Focal | 1 1 2 | 20 1.2|
Autolysis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 4| 4| 1| 6| 4| 7| 7| | |
DAY ON TEST | 9| 9| 6| 2| 6| 0| 2| 6| 3| 3| | |
| 2| 2| 0| 8| 0| 6| 6| 0| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cytoplasmic Alteration, Focal | | 1 2.0|
Ectopic Liver | | 1 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 50 |
Cytoplasmic Alteration, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 50 |
Hyperplasia | 1 2 1 | 20 1.7|
Inflammation, Acute | | 2 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 50 |
Autolysis | | 1 2.0|
Necrosis | 2 | 4 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 19 |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Inflammation, Chronic | 1 1 2 2 1 2 | 39 1.2|
Atrium Left, Thrombosis | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 50 |
Angiectasis | 1 | 3 2.0|
Hyperplasia, Focal | 1 1 | 11 1.1|
Hypertrophy, Focal | | 4 1.0|
Vacuolization Cytoplasmic, Focal | 1 | 4 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 49 |
Hyperplasia, Focal | | 5 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 50 |
Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 50 |
Pars Distalis, Angiectasis | | 2 2.0|
Pars Distalis, Cyst | 1 | 5 1.2|
Pars Distalis, Hyperplasia | 1 | 9 1.3|
Pars Distalis, Hypertrophy | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 4| 4| 1| 6| 4| 7| 7| | |
DAY ON TEST | 9| 9| 6| 2| 6| 0| 2| 6| 3| 3| | |
| 2| 2| 0| 8| 0| 6| 6| 0| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 49 |
C-Cell, Hyperplasia | 1 | 5 1.4|
Follicle, Cyst | | 4 1.3|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + | 45 |
Inflammation, Chronic | | 1 2.0|
Duct, Ectasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 50 |
Follicle, Cyst | 3 | 3 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + | 50 |
Cyst | | 1 2.0|
Hemorrhage | | 1 3.0|
Cervix, Cyst | | 1 2.0|
Endometrium, Cyst | | 4 1.5|
Endometrium, Hyperplasia, Cystic | 2 | 7 1.1|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Inflammation, Acute | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 49 |
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 47 |
Hyperplasia, Re Cell | | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 50 |
Hematopoietic Cell Proliferation | | |
Granulocytic | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 48 |
Cyst | | 3 1.3|
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 4| 4| 1| 6| 4| 7| 7| | |
DAY ON TEST | 9| 9| 6| 2| 6| 0| 2| 6| 3| 3| | |
| 2| 2| 0| 8| 0| 6| 6| 0| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Galactocele | | 1 3.0|
Hyperplasia | 1 | 2 1.5|
Inflammation, Acute | | 1 1.0|
Duct, Ectasia | | 7 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 50 |
Osteopetrosis | | 3 1.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 50 |
Hydrocephalus | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Congestion | 4 2 | 18 1.7|
Hemorrhage | | 1 1.0|
Inflammation, Chronic | | 4 1.3|
Inflammation, Granulomatous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 4 1.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 50 |
Autolysis | 2 | 3 2.3|
Foreign Body | 1 | 4 1.0|
Fungus | | 2 |
Mucosa, Inflammation, Acute | | 3 1.7|
Mucosa, Inflammation, Chronic Active | 2 2 2 | 12 1.9|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 1.0|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 50 |
Inflammation, Acute | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 6| 6| 4| 4| 4| 1| 6| 4| 7| 7| | |
DAY ON TEST | 9| 9| 6| 2| 6| 0| 2| 6| 3| 3| | |
| 2| 2| 0| 8| 0| 6| 6| 0| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5.0MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 2 3.0|
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 50 |
Autolysis | | 1 2.0|
Cyst | 3 | 2 2.5|
Hemorrhage, Focal | 3 | 1 3.0|
Nephropathy | 3 2 1 1 1 2 | 41 1.6|
Pigmentation | 2 | 3 2.0|
Renal Tubule, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 50 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4| 5| 5| 4| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 6| 0| 6| 0| 6| 3| 3| 3| 3| 1| 2| 3| 5| 3| 7| 6| 7| 6| 6| 1| 8| 6| 0| 3| 2|
| 0| 9| 0| 7| 0| 8| 2| 3| 4| 5| 9| 2| 6| 3| 2| 0| 7| 5| 0| 5| 3| 0| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
Edema | 1 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X|
Clear Cell Focus | |
Congestion | 2 |
Cyst | |
Cytoplasmic Alteration, Focal | 2 1 2 2 |
Ectasia | 2 2 |
Eosinophilic Focus | X |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia, Focal | |
Inflammation, Granulomatous, | |
Multifocal | |
Necrosis, Acute | |
Thrombosis, Focal | 2 |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 3 1 1 2 1 2|
Hepatocyte, Degeneration, Cystic | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 1 1 1 1|
Cytoplasmic Alteration, Focal | 1 |
Inflammation, Acute | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4| 5| 5| 4| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 6| 0| 6| 0| 6| 3| 3| 3| 3| 1| 2| 3| 5| 3| 7| 6| 7| 6| 6| 1| 8| 6| 0| 3| 2|
| 0| 9| 0| 7| 0| 8| 2| 3| 4| 5| 9| 2| 6| 3| 2| 0| 7| 5| 0| 5| 3| 0| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 |
Hyperplasia | 2 |
Inflammation, Acute | 1 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 2 2 3 2 1 1 2 2 1 1 2 1 2 2 2 2|
Atrium Left, Thrombosis | 4 |
Endocardium, Fibrosis | |
Epicardium, Inflammation, Chronic, | |
Focal | 3 |
Valve, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Focal | 1 2 1 |
Hypertrophy, Focal | 1|
Vacuolization Cytoplasmic | 1 1 3 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 1 |
Thrombosis | |
Bilateral, Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 1 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4| 5| 5| 4| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 6| 0| 6| 0| 6| 3| 3| 3| 3| 1| 2| 3| 5| 3| 7| 6| 7| 6| 6| 1| 8| 6| 0| 3| 2|
| 0| 9| 0| 7| 0| 8| 2| 3| 4| 5| 9| 2| 6| 3| 2| 0| 7| 5| 0| 5| 3| 0| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Ectasia | |
Pars Distalis, Hyperplasia | 1 1 2 1 |
Pars Distalis, Hypertrophy | 1 |
Pars Distalis, Necrosis, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Duct, Epithelium, Degeneration | |
Fat, Necrosis, Focal | 2 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
Inflammation, Acute | 2 1 1 1 |
Inflammation, Chronic | 3 1 1 1|
Inflammation, Chronic Active | 2 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 2 2|
Inflammation, Acute | 2 3 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
Interstitial Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Hypoplasia | |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Axillary, Congestion | |
Axillary, Hemorrhage | |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4| 5| 5| 4| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 6| 0| 6| 0| 6| 3| 3| 3| 3| 1| 2| 3| 5| 3| 7| 6| 7| 6| 6| 1| 8| 6| 0| 3| 2|
| 0| 9| 0| 7| 0| 8| 2| 3| 4| 5| 9| 2| 6| 3| 2| 0| 7| 5| 0| 5| 3| 0| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + I|
Congestion | |
Cyst | 2 |
Ectopic Parathyroid Gland | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + I + + + + + + +|
Hyperplasia | |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Face, Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 |
Inflammation, Acute, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Congestion | 3 1|
Foreign Body | |
Hemorrhage | 2 |
Inflammation, Acute, Multifocal | 3 |
Inflammation, Chronic | 3 |
Inflammation, Granulomatous | |
Metaplasia, Focal, Osseous | |
Necrosis, Focal | |
Alveolar Epithelium, Hyperplasia | 2 2 1 |
Artery, Media, Hypertrophy | |
Perivascular, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 4| 5| 5| 4| 7| 6| 4| 7| 7| 7|
DAY ON TEST | 6| 0| 6| 0| 6| 3| 3| 3| 3| 1| 2| 3| 5| 3| 7| 6| 7| 6| 6| 1| 8| 6| 0| 3| 2|
| 0| 9| 0| 7| 0| 8| 2| 3| 4| 5| 9| 2| 6| 3| 2| 0| 7| 5| 0| 5| 3| 0| 6| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Foreign Body | |
Fungus | X |
Mucosa, Cyst | |
Mucosa, Inflammation, Chronic | |
Mucosa, Inflammation, Chronic Active | 2 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + +|
Hemorrhage | |
Lens, Cataract | |
Retina, Degeneration | 4 4|
Sclera, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
Nephropathy | 3 3 3 2 3 2 2 4 4 3 3 2 2 1 2 3 2 3 3|
Pigmentation | 3 |
Cortex, Cyst | |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Concretion | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 5| 7| 7| 2| 4| 7| 7| 7|
DAY ON TEST | 3| 9| 6| 1| 3| 3| 3| 3| 5| 0| 3| 0| 3| 3| 2| 3| 5| 8| 3| 3| 7| 6| 3| 3| 0|
| 3| 2| 0| 0| 4| 4| 4| 3| 1| 1| 2| 6| 2| 2| 9| 3| 7| 6| 3| 3| 9| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X |
Clear Cell Focus | X |
Congestion | 3 |
Cyst | 2 |
Cytoplasmic Alteration, Focal | 2 2 2 |
Ectasia | |
Eosinophilic Focus | |
Fibrosis, Focal | 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia, Focal | 2 |
Inflammation, Granulomatous, | |
Multifocal | 1 |
Necrosis, Acute | 3 1 3 1 |
Thrombosis, Focal | |
Vacuolization Cytoplasmic, Focal | 2 2 |
Bile Duct, Hyperplasia | 1 2 2 2 1 2 2 2 |
Hepatocyte, Degeneration, Cystic | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 4 3 3 1 1 1 2 2 1 1 1 1 1 |
Cytoplasmic Alteration, Focal | |
Inflammation, Acute | 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 5| 7| 7| 2| 4| 7| 7| 7|
DAY ON TEST | 3| 9| 6| 1| 3| 3| 3| 3| 5| 0| 3| 0| 3| 3| 2| 3| 5| 8| 3| 3| 7| 6| 3| 3| 0|
| 3| 2| 0| 0| 4| 4| 4| 3| 1| 1| 2| 6| 2| 2| 9| 3| 7| 6| 3| 3| 9| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + M + +|
Edema | |
Hyperplasia | 2 |
Inflammation, Acute | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | 2 |
Necrosis | 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2|
Inflammation, Chronic | 2 2 2 2 2 2 1 2 1 1 3 1 1 1 1 2 1 2 1 |
Atrium Left, Thrombosis | |
Endocardium, Fibrosis | 2 |
Epicardium, Inflammation, Chronic, | |
Focal | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Focal | 1 2 2 1 2 |
Hypertrophy, Focal | 1 1 1 1 |
Vacuolization Cytoplasmic | 1 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 2 |
Thrombosis | 4 |
Bilateral, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 5| 7| 7| 2| 4| 7| 7| 7|
DAY ON TEST | 3| 9| 6| 1| 3| 3| 3| 3| 5| 0| 3| 0| 3| 3| 2| 3| 5| 8| 3| 3| 7| 6| 3| 3| 0|
| 3| 2| 0| 0| 4| 4| 4| 3| 1| 1| 2| 6| 2| 2| 9| 3| 7| 6| 3| 3| 9| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Ectasia | 2 |
Pars Distalis, Hyperplasia | 1 1 1 1 2 2 |
Pars Distalis, Hypertrophy | 1 |
Pars Distalis, Necrosis, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X|
C-Cell, Hyperplasia | 1 1|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Epithelium, Degeneration | 3 |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Inflammation, Acute | 2 2 1 3 4|
Inflammation, Chronic | 2 1 1 1 1 |
Inflammation, Chronic Active | |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Inflammation, Acute | 1 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2|
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 1 |
Interstitial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 2|
Myeloid Cell, Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Congestion | |
Axillary, Hemorrhage | |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 5| 7| 7| 2| 4| 7| 7| 7|
DAY ON TEST | 3| 9| 6| 1| 3| 3| 3| 3| 5| 0| 3| 0| 3| 3| 2| 3| 5| 8| 3| 3| 7| 6| 3| 3| 0|
| 3| 2| 0| 0| 4| 4| 4| 3| 1| 1| 2| 6| 2| 2| 9| 3| 7| 6| 3| 3| 9| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + |
Ectasia | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 2|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
Granulocytic | 4 2 |
__________________________________________________________________________|
Thymus | + + + + + I + + + I + + + + I + + + + + + + +|
Congestion | 2 |
Cyst | 1 1 |
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Duct, Ectasia | 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Face, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
Inflammation, Acute, Focal | 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 3 1 |
Foreign Body | 2 |
Hemorrhage | 1 |
Inflammation, Acute, Multifocal | |
Inflammation, Chronic | 1 2 |
Inflammation, Granulomatous | 2 |
Metaplasia, Focal, Osseous | 1 |
Necrosis, Focal | |
Alveolar Epithelium, Hyperplasia | |
Artery, Media, Hypertrophy | 2 |
Perivascular, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 5| 7| 7| 2| 4| 7| 7| 7|
DAY ON TEST | 3| 9| 6| 1| 3| 3| 3| 3| 5| 0| 3| 0| 3| 3| 2| 3| 5| 8| 3| 3| 7| 6| 3| 3| 0|
| 3| 2| 0| 0| 4| 4| 4| 3| 1| 1| 2| 6| 2| 2| 9| 3| 7| 6| 3| 3| 9| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Foreign Body | 2|
Fungus | |
Mucosa, Cyst | |
Mucosa, Inflammation, Chronic | 2 1 |
Mucosa, Inflammation, Chronic Active | 3 3 2 3 2|
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 3 |
Respiratory Epithelium, Hyperplasia | 3 2 2 3 3|
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Hemorrhage | |
Lens, Cataract | 2 |
Retina, Degeneration | 4 |
Sclera, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 3|
Nephropathy | 3 3 2 3 2 3 2 2 2 3 2 3 3 3 4 2 1 4 3 1 4 3 3|
Pigmentation | 2 |
Cortex, Cyst | 2 2 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 4| 4| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 6| 3| 8| 6| 1| 3| 4| 3| | |
| 2| 2| 0| 4| 0| 0| 5| 4| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 50 |
Edema | | 1 1.0|
Hyperplasia, Lymphoid | | 2 2.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 50 |
Inflammation, Chronic | | 1 1.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 50 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 49 |
Hyperplasia, Lymphoid | | 4 1.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 49 |
Metaplasia, Osseous | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Basophilic Focus, Multiple | X X X | 17 |
Clear Cell Focus | | 1 |
Congestion | | 2 2.5|
Cyst | | 1 2.0|
Cytoplasmic Alteration, Focal | | 7 1.9|
Ectasia | | 2 2.0|
Eosinophilic Focus | | 1 |
Fibrosis, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 8 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | | 1 1.0|
Necrosis, Acute | | 4 2.0|
Thrombosis, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 3 2.0|
Bile Duct, Hyperplasia | 3 1 2 | 17 1.8|
Hepatocyte, Degeneration, Cystic | 2 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis, Focal | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 4| 4| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 6| 3| 8| 6| 1| 3| 4| 3| | |
| 2| 2| 0| 4| 0| 0| 5| 4| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Atrophy, Focal | 2 1 1 1 1 2 | 25 1.5|
Cytoplasmic Alteration, Focal | | 1 1.0|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
Inflammation, Chronic | | 1 1.0|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 49 |
Edema | | 2 2.5|
Hyperplasia | 1 | 3 1.7|
Inflammation, Acute | 2 | 2 1.5|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Acute | | 2 2.5|
Necrosis | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 16 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 2 2 1 2 1 2 2 2 | 44 1.7|
Atrium Left, Thrombosis | | 1 4.0|
Endocardium, Fibrosis | | 1 2.0|
Epicardium, Inflammation, Chronic, | | |
Focal | | 1 3.0|
Valve, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Congestion | | 1 2.0|
Hyperplasia, Focal | 1 1 | 10 1.4|
Hypertrophy, Focal | | 5 1.0|
Vacuolization Cytoplasmic | 1 1 | 10 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + + + + + | 48 |
Hyperplasia, Focal | 1 | 8 1.1|
Thrombosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 4| 4| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 6| 3| 8| 6| 1| 3| 4| 3| | |
| 2| 2| 0| 4| 0| 0| 5| 4| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Bilateral, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + | 49 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 50 |
Pars Distalis, Angiectasis | 2 | 2 2.5|
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 1 1.0|
Pars Distalis, Ectasia | | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 | 12 1.4|
Pars Distalis, Hypertrophy | | 2 1.0|
Pars Distalis, Necrosis, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | | 6 1.0|
Follicle, Cyst | 1 | 1 1.0|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
Duct, Epithelium, Degeneration | | 1 3.0|
Fat, Necrosis, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 49 |
Hyperplasia | | 2 2.5|
Inflammation, Acute | 2 1 | 11 1.8|
Inflammation, Chronic | | 9 1.3|
Inflammation, Chronic Active | 2 | 2 2.0|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 49 |
Hyperplasia, Focal | 2 2 | 8 1.8|
Inflammation, Acute | 1 | 5 1.6|
Inflammation, Chronic | 1 | 2 1.5|
Inflammation, Chronic Active | | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 4| 4| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 6| 3| 8| 6| 1| 3| 4| 3| | |
| 2| 2| 0| 4| 0| 0| 5| 4| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Atrophy | | 3 3.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 3 1.7|
Interstitial Cell, Hyperplasia | | 3 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Hypoplasia | | 1 2.0|
Myeloid Cell, Hyperplasia | | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M | 49 |
Axillary, Congestion | 1 | 1 1.0|
Axillary, Hemorrhage | 2 | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 42 |
Ectasia | | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Congestion | | 4 2.0|
Fibrosis | | 2 2.5|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 46 |
Congestion | | 1 2.0|
Cyst | | 3 1.3|
Ectopic Parathyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 47 |
Hyperplasia | 1 | 2 1.0|
Duct, Ectasia | 1 2 | 5 1.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Cyst | 2 | 2 1.5|
Face, Inflammation, Acute | | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 4| 4| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 6| 3| 8| 6| 1| 3| 4| 3| | |
| 2| 2| 0| 4| 0| 0| 5| 4| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Fibrous Osteodystrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Hydrocephalus | 2 3 | 4 2.0|
Inflammation, Acute, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | 2 1 | 8 1.8|
Foreign Body | | 1 2.0|
Hemorrhage | 1 1 2 | 5 1.4|
Inflammation, Acute, Multifocal | | 1 3.0|
Inflammation, Chronic | 2 | 4 2.0|
Inflammation, Granulomatous | 1 | 2 1.5|
Metaplasia, Focal, Osseous | | 1 1.0|
Necrosis, Focal | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 3 1.7|
Artery, Media, Hypertrophy | | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Autolysis | | 1 2.0|
Foreign Body | | 1 2.0|
Fungus | | 1 |
Mucosa, Cyst | 1 | 1 1.0|
Mucosa, Inflammation, Chronic | | 2 1.5|
Mucosa, Inflammation, Chronic Active | | 7 2.6|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 3 2.3|
Respiratory Epithelium, Hyperplasia | | 5 2.6|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 4| 4| 7| 7| 5| 7| | |
DAY ON TEST | 3| 3| 6| 3| 8| 6| 1| 3| 4| 3| | |
| 2| 2| 0| 4| 0| 0| 5| 4| 6| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Hemorrhage | 4 | 1 4.0|
Lens, Cataract | | 1 2.0|
Retina, Degeneration | | 3 4.0|
Sclera, Inflammation, Acute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Inflammation, Acute, Focal | | 1 3.0|
Nephropathy | 3 3 4 2 3 2 2 3 | 50 2.7|
Pigmentation | | 2 2.5|
Cortex, Cyst | 2 | 3 2.0|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
Concretion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 1| 5| 6| 5| 4| 2| 2| 6| 7| 6| 3| 6| 5| 3| 6| 0| 6| 6| 6| 6| 7| 4| 6| 4| 6|
DAY ON TEST | 7| 4| 8| 2| 6| 7| 9| 6| 2| 6| 3| 6| 1| 9| 2| 9| 8| 0| 6| 0| 3| 6| 9| 6| 3|
| 5| 4| 0| 3| 0| 7| 1| 9| 9| 6| 3| 4| 9| 8| 7| 2| 0| 8| 6| 0| 2| 0| 5| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Edema | |
Hemorrhage | 2 |
Inflammation, Acute | 1 4 |
Inflammation, Chronic | 1 |
Ulcer | 1 4 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Acute | |
Mineralization | |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + I + + + + + + I + + + + M + +|
Autolysis | |
Inflammation, Chronic | 1 |
Mineralization | 2 |
Parasite Metazoan | X X|
Ulcer | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + M + + + + + + + +|
Autolysis | 3 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
Inflammation, Chronic | |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 3 3 4 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Autolysis | |
Basophilic Focus, Multiple | X X |
Congestion | 2 2 2 |
Cytoplasmic Alteration, Focal | |
Ectasia | |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X X|
Inflammation, Chronic | 1 |
Necrosis, Acute | 1 2 2 |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 3 2 2 2 1 2 1 2|
Hepatocyte, Degeneration, Cystic | 1 |
__________________________________________________________________________|
Mesentery | + + + + |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 1| 5| 6| 5| 4| 2| 2| 6| 7| 6| 3| 6| 5| 3| 6| 0| 6| 6| 6| 6| 7| 4| 6| 4| 6|
DAY ON TEST | 7| 4| 8| 2| 6| 7| 9| 6| 2| 6| 3| 6| 1| 9| 2| 9| 8| 0| 6| 0| 3| 6| 9| 6| 3|
| 5| 4| 0| 3| 0| 7| 1| 9| 9| 6| 3| 4| 9| 8| 7| 2| 0| 8| 6| 0| 2| 0| 5| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hemorrhage, Focal | |
Inflammation, Chronic | |
Fat, Necrosis, Focal | 2 3 3 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 1 1 1 1 2|
Autolysis | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 3 1 2 2 2|
Inflammation, Acute | 4 1 |
Mineralization | 2 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
Mineralization | 3 2 3 1 |
Necrosis | 1 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 2 2 3 2 1 2 2 3 1 3 1 1 2 2 2 3 1 2 2|
Mineralization | 2 2 1 2 |
Atrium Left, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Congestion | 2|
Hyperplasia, Focal | 1 |
Vacuolization Cytoplasmic | 1 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + M + + M + + + +|
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 1| 5| 6| 5| 4| 2| 2| 6| 7| 6| 3| 6| 5| 3| 6| 0| 6| 6| 6| 6| 7| 4| 6| 4| 6|
DAY ON TEST | 7| 4| 8| 2| 6| 7| 9| 6| 2| 6| 3| 6| 1| 9| 2| 9| 8| 0| 6| 0| 3| 6| 9| 6| 3|
| 5| 4| 0| 3| 0| 7| 1| 9| 9| 6| 3| 4| 9| 8| 7| 2| 0| 8| 6| 0| 2| 0| 5| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 1 2 |
Pars Distalis, Hyperplasia | 1 1 2 1 |
Pars Distalis, Hypertrophy | 2 |
Pars Nervosa, Cyst | |
Pars Nervosa, Hyperplasia | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia, Cystic | 4 |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | |
Duct, Epithelium, Degeneration | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 2 1 1 4 |
Inflammation, Chronic | 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 1 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
Interstitial Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + M|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + M + + + + + + + + +|
Granuloma | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 1| 5| 6| 5| 4| 2| 2| 6| 7| 6| 3| 6| 5| 3| 6| 0| 6| 6| 6| 6| 7| 4| 6| 4| 6|
DAY ON TEST | 7| 4| 8| 2| 6| 7| 9| 6| 2| 6| 3| 6| 1| 9| 2| 9| 8| 0| 6| 0| 3| 6| 9| 6| 3|
| 5| 4| 0| 3| 0| 7| 1| 9| 9| 6| 3| 4| 9| 8| 7| 2| 0| 8| 6| 0| 2| 0| 5| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation | |
Mandibular, Hemorrhage | |
Mandibular, Inflammation, Acute, | |
Focal | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + +|
Autolysis | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 |
Hyperplasia | |
Hyperplasia, Plasma Cell | |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Congestion | |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Pigmentation | 2 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + I + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + M|
Fibrous Osteodystrophy | 2 2 2 2 3 1 2 1 1 |
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Meninges, Congestion | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 1| 5| 6| 5| 4| 2| 2| 6| 7| 6| 3| 6| 5| 3| 6| 0| 6| 6| 6| 6| 7| 4| 6| 4| 6|
DAY ON TEST | 7| 4| 8| 2| 6| 7| 9| 6| 2| 6| 3| 6| 1| 9| 2| 9| 8| 0| 6| 0| 3| 6| 9| 6| 3|
| 5| 4| 0| 3| 0| 7| 1| 9| 9| 6| 3| 4| 9| 8| 7| 2| 0| 8| 6| 0| 2| 0| 5| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 2 2 2 3 2 2 1 2|
Fibrosis, Focal | |
Hemorrhage | 2 |
Inflammation, Acute, Chronic | 4 |
Inflammation, Acute, Multifocal | 3 3 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + I + + + + + + + M + + M|
Autolysis | 2 2 2 1 |
Foreign Body | 2 |
Fungus | |
Hemorrhage | |
Hyperplasia, Squamous | |
Mucosa, Inflammation, Acute | 2 |
Mucosa, Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Cyst | |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Bilateral, Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Acute, Focal | |
Nephropathy | 3 4 3 1 2 4 4 4 1 4 3 2 4 4 4 4 4 4 4 3|
Cortex, Cyst | |
Renal Tubule, Hyperplasia, Cystic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 6| 6| 3| 4| 6| 1| 7| 6| 6| 3| 4| 4| 4| 6| 6| 4| 7| 7| 7| 7| 1| 6| 6| 7| 7|
DAY ON TEST | 9| 5| 8| 6| 6| 5| 3| 8| 9| 7| 6| 6| 6| 1| 6| 6| 2| 2| 3| 3| 4| 9| 7| 0| 1|
| 0| 1| 5| 0| 6| 6| 2| 5| 3| 5| 0| 0| 0| 4| 7| 0| 9| 9| 4| 3| 9| 1| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 4 |
Edema | |
Hemorrhage | 2 |
Inflammation, Acute | 1 1 2 4|
Inflammation, Chronic | 3 |
Ulcer | 3 4 4 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 3 |
Inflammation, Acute | |
Mineralization | 2 |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + I + + + + + + + + + +|
Autolysis | 2 |
Inflammation, Chronic | 3 |
Mineralization | |
Parasite Metazoan | X |
Ulcer | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 4 3 |
Inflammation, Chronic | 2 |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 4 3 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Autolysis | 3 |
Basophilic Focus, Multiple | X X X |
Congestion | |
Cytoplasmic Alteration, Focal | 2 3 2 |
Ectasia | 2 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | |
Necrosis, Acute | 3 3 1|
Vacuolization Cytoplasmic, Focal | 2 |
Bile Duct, Hyperplasia | 2 1 2 1 1 1 2 1 2 2 1|
Hepatocyte, Degeneration, Cystic | 2 2 2 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 6| 6| 3| 4| 6| 1| 7| 6| 6| 3| 4| 4| 4| 6| 6| 4| 7| 7| 7| 7| 1| 6| 6| 7| 7|
DAY ON TEST | 9| 5| 8| 6| 6| 5| 3| 8| 9| 7| 6| 6| 6| 1| 6| 6| 2| 2| 3| 3| 4| 9| 7| 0| 1|
| 0| 1| 5| 0| 6| 6| 2| 5| 3| 5| 0| 0| 0| 4| 7| 0| 9| 9| 4| 3| 9| 1| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hemorrhage, Focal | 2 |
Inflammation, Chronic | 1 |
Fat, Necrosis, Focal | 2 2 2 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 2 2 1 1|
Autolysis | 3 3 |
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 3 2 |
Inflammation, Acute | |
Mineralization | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Mineralization | 2 2 2 3|
Necrosis | 1 |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + |
Mineralization | 3 2 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic | 2 3 1 3 1 2 1 2 2 2 2 2 3 2 2 1 2 2 2 2|
Mineralization | 2 2 2 1 2 3 2 1|
Atrium Left, Thrombosis | 3 3 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Congestion | |
Hyperplasia, Focal | 1 |
Vacuolization Cytoplasmic | 2 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + M + +|
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 6| 6| 3| 4| 6| 1| 7| 6| 6| 3| 4| 4| 4| 6| 6| 4| 7| 7| 7| 7| 1| 6| 6| 7| 7|
DAY ON TEST | 9| 5| 8| 6| 6| 5| 3| 8| 9| 7| 6| 6| 6| 1| 6| 6| 2| 2| 3| 3| 4| 9| 7| 0| 1|
| 0| 1| 5| 0| 6| 6| 2| 5| 3| 5| 0| 0| 0| 4| 7| 0| 9| 9| 4| 3| 9| 1| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 2 2 2 2 2 2 2 1 2 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis | 2 2|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 1 2 2 3 |
Pars Distalis, Hypertrophy | |
Pars Nervosa, Cyst | |
Pars Nervosa, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia, Cystic | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + M + +|
Cytomegaly | 2 |
Duct, Epithelium, Degeneration | 2 2 |
__________________________________________________________________________|
Preputial Gland | + M + + + + + + + + + + + + + + + M + +|
Inflammation, Acute | 3 2 1 3 4|
Inflammation, Chronic | 1 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + M + +|
Atrophy | 2 4 |
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 1 3 3 2 |
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + + + + + + +|
Granuloma | 1 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 6| 6| 3| 4| 6| 1| 7| 6| 6| 3| 4| 4| 4| 6| 6| 4| 7| 7| 7| 7| 1| 6| 6| 7| 7|
DAY ON TEST | 9| 5| 8| 6| 6| 5| 3| 8| 9| 7| 6| 6| 6| 1| 6| 6| 2| 2| 3| 3| 4| 9| 7| 0| 1|
| 0| 1| 5| 0| 6| 6| 2| 5| 3| 5| 0| 0| 0| 4| 7| 0| 9| 9| 4| 3| 9| 1| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation | 2 |
Mandibular, Hemorrhage | 2|
Mandibular, Inflammation, Acute, | |
Focal | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + |
Autolysis | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 |
Hyperplasia, Plasma Cell | 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Congestion | |
Fibrosis | 1 2 |
Hematopoietic Cell Proliferation | 3 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 |
Pigmentation | |
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + I + + + + + + + M + + + I + +|
Congestion | 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3 2 2 2 2 3 2 2 2 2 2 3|
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Meninges, Congestion | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 6| 6| 3| 4| 6| 1| 7| 6| 6| 3| 4| 4| 4| 6| 6| 4| 7| 7| 7| 7| 1| 6| 6| 7| 7|
DAY ON TEST | 9| 5| 8| 6| 6| 5| 3| 8| 9| 7| 6| 6| 6| 1| 6| 6| 2| 2| 3| 3| 4| 9| 7| 0| 1|
| 0| 1| 5| 0| 6| 6| 2| 5| 3| 5| 0| 0| 0| 4| 7| 0| 9| 9| 4| 3| 9| 1| 1| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 2 2 2 2 |
Fibrosis, Focal | 1 |
Hemorrhage | 1 2 1 |
Inflammation, Acute, Chronic | |
Inflammation, Acute, Multifocal | 3 4 |
Inflammation, Chronic | 2 1 |
Alveolar Epithelium, Hyperplasia | 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
Foreign Body | 2 |
Fungus | X |
Hemorrhage | 3 |
Hyperplasia, Squamous | 4 |
Mucosa, Inflammation, Acute | 1 1 |
Mucosa, Inflammation, Chronic Active | 2 3 2 |
Nasolacrimal Duct, Cyst | 1 |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Bilateral, Lens, Cataract | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 |
Inflammation, Acute, Focal | 2 |
Nephropathy | 4 4 2 4 4 4 4 1 4 2 4 4 4 3 4 3 4 4|
Cortex, Cyst | 2 1 1 |
Renal Tubule, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 7| 7| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 8| 6| 3| 3| 9| 3| 2| 2| 6| | |
| 3| 6| 0| 4| 3| 7| 2| 0| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 50 |
Autolysis | | 3 3.7|
Edema | 2 | 1 2.0|
Hemorrhage | 3 | 3 2.3|
Inflammation, Acute | | 6 2.2|
Inflammation, Chronic | | 2 2.0|
Ulcer | 4 | 8 3.4|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 50 |
Autolysis | | 2 3.5|
Inflammation, Acute | 1 | 1 1.0|
Mineralization | 2 | 2 2.0|
Parasite Metazoan | X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 46 |
Autolysis | | 1 2.0|
Inflammation, Chronic | | 2 2.0|
Mineralization | | 1 2.0|
Parasite Metazoan | X | 4 |
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 49 |
Autolysis | | 4 3.3|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 50 |
Autolysis | | 5 3.4|
Inflammation, Chronic | | 1 2.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 50 |
Autolysis | | 9 3.6|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Angiectasis | 2 2 | 6 2.0|
Autolysis | | 1 3.0|
Basophilic Focus, Multiple | X X | 7 |
Congestion | | 3 2.0|
Cytoplasmic Alteration, Focal | | 3 2.3|
Ectasia | | 1 2.0|
Eosinophilic Focus | | 2 |
Hepatodiaphragmatic Nodule | X | 6 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 7| 7| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 8| 6| 3| 3| 9| 3| 2| 2| 6| | |
| 3| 6| 0| 4| 3| 7| 2| 0| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis, Acute | | 6 2.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 2 1 2 | 22 1.6|
Hepatocyte, Degeneration, Cystic | 2 | 7 1.6|
__________________________________________________________________________|____________|
Mesentery | + | 10 |
Hemorrhage, Focal | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Fat, Necrosis, Focal | 2 | 8 2.4|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Atrophy, Focal | 2 1 | 15 1.5|
Autolysis | | 2 3.0|
Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Hyperplasia | 1 2 1 | 16 1.6|
Inflammation, Acute | 1 | 3 2.0|
Mineralization | | 5 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 | 2 1.5|
Mineralization | 1 | 9 2.1|
Necrosis | | 2 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 41 |
Mineralization | 1 | 6 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 2 2 2 2 2 3 2 1 | 48 2.0|
Mineralization | 2 | 13 1.8|
Atrium Left, Thrombosis | | 5 2.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 7| 7| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 8| 6| 3| 3| 9| 3| 2| 2| 6| | |
| 3| 6| 0| 4| 3| 7| 2| 0| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Accessory Adrenal Cortical Nodule | X | 1 |
Congestion | | 1 2.0|
Hyperplasia, Focal | 1 | 3 1.0|
Vacuolization Cytoplasmic | | 8 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 50 |
Hyperplasia, Focal | 2 | 8 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
Autolysis | | 2 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + | 44 |
Hyperplasia, Focal | 2 2 | 2 2.0|
Hyperplasia | 2 2 2 | 23 1.9|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 49 |
Hemorrhage | | 1 3.0|
Pars Distalis, Angiectasis | | 2 2.0|
Pars Distalis, Cyst | 3 | 4 2.0|
Pars Distalis, Hyperplasia | 1 | 9 1.6|
Pars Distalis, Hypertrophy | 1 | 2 1.5|
Pars Nervosa, Cyst | 3 | 1 3.0|
Pars Nervosa, Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
Hemorrhage | 1 | 2 2.0|
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | | 2 2.0|
Follicle, Cyst | 1 | 1 1.0|
Follicular Cell, Hyperplasia, Cystic | | 1 4.0|
Follicular Cell, Hyperplasia | | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 49 |
Cytomegaly | | 1 2.0|
Duct, Epithelium, Degeneration | | 3 2.3|
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + M | 46 |
Inflammation, Acute | 2 1 | 12 2.3|
Inflammation, Chronic | | 2 1.5|
Duct, Ectasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 7| 7| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 8| 6| 3| 3| 9| 3| 2| 2| 6| | |
| 3| 6| 0| 4| 3| 7| 2| 0| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Acute | 1 1 | 4 1.8|
Inflammation, Chronic | | 4 1.3|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 49 |
Atrophy | | 3 3.3|
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 1 2.0|
Interstitial Cell, Hyperplasia | 2 | 4 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 49 |
Myeloid Cell, Hyperplasia | 3 | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 48 |
Granuloma | | 1 1.0|
Inflammation | | 1 2.0|
Mandibular, Hemorrhage | | 1 2.0|
Mandibular, Inflammation, Acute, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 42 |
Autolysis | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 1.0|
Hyperplasia | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Atrophy, Focal | | 1 2.0|
Congestion | 2 | 1 2.0|
Fibrosis | | 2 1.5|
Hematopoietic Cell Proliferation | | 2 2.5|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 2.0|
Pigmentation | | 1 2.0|
Capsule, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 46 |
Congestion | | 3 2.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 7| 7| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 8| 6| 3| 3| 9| 3| 2| 2| 6| | |
| 3| 6| 0| 4| 3| 7| 2| 0| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 50 |
Hyperplasia | | 1 2.0|
Duct, Ectasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 49 |
Fibrous Osteodystrophy | 2 2 2 2 3 | 27 2.1|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Hemorrhage | | 1 2.0|
Meninges, Congestion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | 2 | 13 2.0|
Fibrosis, Focal | | 1 1.0|
Hemorrhage | | 4 1.5|
Inflammation, Acute, Chronic | | 1 4.0|
Inflammation, Acute, Multifocal | 3 | 5 3.2|
Inflammation, Chronic | | 3 1.7|
Alveolar Epithelium, Hyperplasia | | 5 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 3 1.3|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 47 |
Autolysis | | 6 2.2|
Foreign Body | 2 | 3 2.0|
Fungus | | 1 |
Hemorrhage | | 1 3.0|
Hyperplasia, Squamous | | 1 4.0|
Mucosa, Inflammation, Acute | 2 | 4 1.5|
Mucosa, Inflammation, Chronic Active | | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 7| 7| 6| 7| 6| 6| 4| | |
DAY ON TEST | 2| 8| 6| 3| 3| 9| 3| 2| 2| 6| | |
| 3| 6| 0| 4| 3| 7| 2| 0| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Cyst | | 1 1.0|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Bilateral, Lens, Cataract | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Congestion | | 3 2.0|
Inflammation, Acute, Focal | | 1 2.0|
Nephropathy | 3 3 4 3 4 4 4 3 | 46 3.4|
Cortex, Cyst | 2 3 | 5 1.8|
Renal Tubule, Hyperplasia, Cystic | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 6| 5| 5| 6| 4| 5| 6| 6| 5| 5| 5| 7| 6| 4| 4| 5| 7| 7| 4| 7| 6|
DAY ON TEST | 6| 0| 4| 6| 6| 6| 5| 5| 1| 7| 2| 7| 8| 7| 9| 1| 1| 6| 7| 2| 3| 2| 6| 0| 2|
| 7| 7| 4| 3| 4| 5| 4| 8| 1| 3| 1| 6| 6| 3| 5| 9| 9| 0| 0| 6| 3| 9| 0| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Congestion | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Inflammation, Acute | 3 2 2 4|
Inflammation, Chronic | |
Parasite Metazoan | X |
Ulcer | 4 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Inflammation, Chronic | 3 1 2|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute, Chronic | |
Inflammation, Chronic | 1|
Ulcer | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + + + + + + + + +|
Autolysis | 4 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 4 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Basophilic Focus, Multiple | X |
Congestion | 1 |
Cytoplasmic Alteration, Focal | 2 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | |
Necrosis, Acute | 2 2 1 |
Bile Duct, Hyperplasia | 2 1 1 3 2 1 1 1|
Hepatocyte, Degeneration, Cystic | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Acute, Focal | 2 |
Fat, Necrosis, Focal | 2 2 |
Fat, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 6| 5| 5| 6| 4| 5| 6| 6| 5| 5| 5| 7| 6| 4| 4| 5| 7| 7| 4| 7| 6|
DAY ON TEST | 6| 0| 4| 6| 6| 6| 5| 5| 1| 7| 2| 7| 8| 7| 9| 1| 1| 6| 7| 2| 3| 2| 6| 0| 2|
| 7| 7| 4| 3| 4| 5| 4| 8| 1| 3| 1| 6| 6| 3| 5| 9| 9| 0| 0| 6| 3| 9| 0| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 4 2 2 2 1 1 1 1 1 1 2 |
Autolysis | 4 |
Inflammation, Focal, Granulomatous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Cyst Epithelial Inclusion | |
Hyperplasia | 2 1 2 2 1 2 1 1 1 1 2 1 1 1 2 3 2|
Inflammation, Acute | 1 1 2 |
Mineralization | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Hyperplasia | |
Inflammation, Acute | |
Inflammation, Chronic | |
Mineralization | 1 4 |
Necrosis | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 1 2 2 1 2 2 1 2 2 2 3 2 2 2 2 2 1 2 3 1|
Mineralization | 3 1 3 1 2 2 |
Atrium Left, Thrombosis | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hyperplasia, Focal | 1 3 1 |
Hypertrophy, Focal | |
Inflammation, Chronic, Multifocal | 2 |
Mineralization, Multifocal | 2 |
Vacuolization Cytoplasmic | 1 2 2 1|
Capsule, Ectopic Tissue | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Bilateral, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 6| 5| 5| 6| 4| 5| 6| 6| 5| 5| 5| 7| 6| 4| 4| 5| 7| 7| 4| 7| 6|
DAY ON TEST | 6| 0| 4| 6| 6| 6| 5| 5| 1| 7| 2| 7| 8| 7| 9| 1| 1| 6| 7| 2| 3| 2| 6| 0| 2|
| 7| 7| 4| 3| 4| 5| 4| 8| 1| 3| 1| 6| 6| 3| 5| 9| 9| 0| 0| 6| 3| 9| 0| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia | 1 2 2|
Pars Nervosa, Cyst | 1 |
Pars Nervosa, Inflammation, | |
Granulomatous | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Epithelium, Degeneration | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Acute | 1 1 1 1 |
Inflammation, Chronic | 1 2 3 1 1 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Bilateral, Atrophy | 2 3|
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
Interstitial Cell, Hyperplasia | 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Cellular, Focal | 2 3|
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 6| 5| 5| 6| 4| 5| 6| 6| 5| 5| 5| 7| 6| 4| 4| 5| 7| 7| 4| 7| 6|
DAY ON TEST | 6| 0| 4| 6| 6| 6| 5| 5| 1| 7| 2| 7| 8| 7| 9| 1| 1| 6| 7| 2| 3| 2| 6| 0| 2|
| 7| 7| 4| 3| 4| 5| 4| 8| 1| 3| 1| 6| 6| 3| 5| 9| 9| 0| 0| 6| 3| 9| 0| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | 1 |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia | 1 |
Renal, Hemorrhage | 1 |
Renal, Hyperplasia | 1 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 3 |
Necrosis, Focal | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | I + + + + + + + I + + + + + I + + + + + + + +|
Autolysis | |
Cyst | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + I + + + + + + +|
Hyperplasia | 1 |
Duct, Ectasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Face, Inflammation, Acute | 1 1 |
Tail, Hemorrhage | 2 |
Tail, Subcutaneous Tissue, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3 2 2 1 2 3 2 2|
Osteomalacia | 4 |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Acute, Focal | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 6| 5| 5| 6| 4| 5| 6| 6| 5| 5| 5| 7| 6| 4| 4| 5| 7| 7| 4| 7| 6|
DAY ON TEST | 6| 0| 4| 6| 6| 6| 5| 5| 1| 7| 2| 7| 8| 7| 9| 1| 1| 6| 7| 2| 3| 2| 6| 0| 2|
| 7| 7| 4| 3| 4| 5| 4| 8| 1| 3| 1| 6| 6| 3| 5| 9| 9| 0| 0| 6| 3| 9| 0| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Fibrosis, Focal | |
Hemorrhage | 2 2 1 |
Inflammation, Acute, Multifocal | 2 |
Inflammation, Chronic | |
Inflammation, Granulomatous | |
Necrosis, Focal | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 2 2 1|
Foreign Body | 1 |
Fungus | X |
Inflammation, Chronic Active | 2 |
Mucosa, Inflammation, Acute | 2 |
Mucosa, Inflammation, Chronic Active | 2 3 2 3 2 |
Nasolacrimal Duct, Cyst | |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Respiratory Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Mineralization | 2 |
Nephropathy | 2 4 2 1 4 4 4 3 1 4 3 3 4 2 4 4 4 4 3 3 4 4 4|
Cortex, Cyst | 2 2 |
Renal Tubule, Hyperplasia, Cystic | 1 |
Renal Tubule, Hyperplasia | 3 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 1| 5| 4| 6| 6| 4| 4| 7| 4| 5| 6| 6| 6| 5| 7| 6| 4| 4| 4| 7|
DAY ON TEST | 1| 3| 6| 4| 2| 7| 9| 6| 5| 3| 6| 6| 2| 6| 6| 6| 3| 8| 7| 3| 6| 6| 9| 6| 1|
| 5| 3| 0| 4| 9| 3| 9| 0| 2| 3| 0| 0| 9| 0| 9| 9| 8| 7| 3| 2| 7| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Congestion | 1 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Acute | 4 1 |
Inflammation, Chronic | 1 1 |
Parasite Metazoan | |
Ulcer | 4 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Acute | 4 4 |
Inflammation, Chronic | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Acute, Chronic | |
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Basophilic Focus, Multiple | X X X X |
Congestion | |
Cytoplasmic Alteration, Focal | 1|
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 |
Necrosis, Acute | 2 1 3 2 |
Bile Duct, Hyperplasia | 1 1 1 1 2 |
Hepatocyte, Degeneration, Cystic | 1 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Acute, Focal | |
Fat, Necrosis, Focal | 3 |
Fat, Necrosis | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 1| 5| 4| 6| 6| 4| 4| 7| 4| 5| 6| 6| 6| 5| 7| 6| 4| 4| 4| 7|
DAY ON TEST | 1| 3| 6| 4| 2| 7| 9| 6| 5| 3| 6| 6| 2| 6| 6| 6| 3| 8| 7| 3| 6| 6| 9| 6| 1|
| 5| 3| 0| 4| 9| 3| 9| 0| 2| 3| 0| 0| 9| 0| 9| 9| 8| 7| 3| 2| 7| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 3 2 |
Autolysis | |
Inflammation, Focal, Granulomatous | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Autolysis | |
Cyst Epithelial Inclusion | 4 |
Hyperplasia | 1 1 1 1 1 1 1 1 2 1 2 2 1 |
Inflammation, Acute | 1 |
Mineralization | 3 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia | 1 |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Mineralization | 1 1 |
Necrosis | 2 1 2 1 |
Ulcer | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + |
Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 3 1 2 1 1 2 1 2 2 2 2 3 3 1 2 3 2|
Mineralization | 2 1 1 2 2 1 |
Atrium Left, Thrombosis | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Focal | 1 1 1 1 |
Hypertrophy, Focal | |
Inflammation, Chronic, Multifocal | |
Mineralization, Multifocal | |
Vacuolization Cytoplasmic | 1 2 |
Capsule, Ectopic Tissue | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 1 |
Bilateral, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 1| 5| 4| 6| 6| 4| 4| 7| 4| 5| 6| 6| 6| 5| 7| 6| 4| 4| 4| 7|
DAY ON TEST | 1| 3| 6| 4| 2| 7| 9| 6| 5| 3| 6| 6| 2| 6| 6| 6| 3| 8| 7| 3| 6| 6| 9| 6| 1|
| 5| 3| 0| 4| 9| 3| 9| 0| 2| 3| 0| 0| 9| 0| 9| 9| 8| 7| 3| 2| 7| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 2 1 |
Pars Nervosa, Cyst | |
Pars Nervosa, Inflammation, | |
Granulomatous | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | 2 1 |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
Duct, Epithelium, Degeneration | 2 |
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1|
Inflammation, Chronic | 1 1 |
Duct, Hyperplasia | 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Bilateral, Atrophy | |
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Interstitial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Cellular, Focal | |
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 1| 5| 4| 6| 6| 4| 4| 7| 4| 5| 6| 6| 6| 5| 7| 6| 4| 4| 4| 7|
DAY ON TEST | 1| 3| 6| 4| 2| 7| 9| 6| 5| 3| 6| 6| 2| 6| 6| 6| 3| 8| 7| 3| 6| 6| 9| 6| 1|
| 5| 3| 0| 4| 9| 3| 9| 0| 2| 3| 0| 0| 9| 0| 9| 9| 8| 7| 3| 2| 7| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | |
Renal, Hemorrhage | |
Renal, Hyperplasia | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
Congestion | 1|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Necrosis, Focal | 2 |
Capsule, Fibrosis | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + I + + + + + + + +|
Autolysis | |
Cyst | 2 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + I + + + + + + I|
Hyperplasia | |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Face, Inflammation, Acute | 1 |
Tail, Hemorrhage | |
Tail, Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X X 2 3 2 2 X 2|
Osteomalacia | |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Acute, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 7| 1| 5| 4| 6| 6| 4| 4| 7| 4| 5| 6| 6| 6| 5| 7| 6| 4| 4| 4| 7|
DAY ON TEST | 1| 3| 6| 4| 2| 7| 9| 6| 5| 3| 6| 6| 2| 6| 6| 6| 3| 8| 7| 3| 6| 6| 9| 6| 1|
| 5| 3| 0| 4| 9| 3| 9| 0| 2| 3| 0| 0| 9| 0| 9| 9| 8| 7| 3| 2| 7| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 2 |
Fibrosis, Focal | 1 |
Hemorrhage | 2 2|
Inflammation, Acute, Multifocal | |
Inflammation, Chronic | 2 2 2 |
Inflammation, Granulomatous | 1 |
Necrosis, Focal | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Foreign Body | 1 |
Fungus | |
Inflammation, Chronic Active | |
Mucosa, Inflammation, Acute | 1 |
Mucosa, Inflammation, Chronic Active | 2 2 1 2 1 1 1 2 1|
Nasolacrimal Duct, Cyst | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Respiratory Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Mineralization | 2 |
Nephropathy | 4 4 4 4 3 3 3 3 4 4 4 4 4 3 4 3 4|
Cortex, Cyst | 2 2 |
Renal Tubule, Hyperplasia, Cystic | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 5| 3| 7| 6| 4| 6| 6| 6| 6| 6| | |
DAY ON TEST | 9| 6| 1| 6| 6| 7| 0| 1| 3| 9| | |
| 5| 1| 0| 7| 0| 6| 6| 0| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 50 |
Autolysis | | 2 3.5|
Congestion | 1 | 2 1.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Acute | 3 | 7 2.7|
Inflammation, Chronic | 3 | 3 1.7|
Parasite Metazoan | | 1 |
Ulcer | | 4 3.8|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 50 |
Autolysis | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Inflammation, Acute | | 2 4.0|
Inflammation, Chronic | | 3 2.0|
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 50 |
Hemorrhage | | 1 1.0|
Inflammation, Acute, Chronic | 4 | 1 4.0|
Inflammation, Chronic | 1 | 2 1.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 50 |
Autolysis | 3 | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 49 |
Autolysis | 3 | 3 3.3|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 50 |
Autolysis | 3 | 4 3.8|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Basophilic Focus | | 1 |
Basophilic Focus, Multiple | X | 6 |
Congestion | | 1 1.0|
Cytoplasmic Alteration, Focal | | 2 1.5|
Eosinophilic Focus | | 2 |
Hepatodiaphragmatic Nodule | | 7 |
Inflammation, Chronic | | 1 1.0|
Necrosis, Acute | 1 1 1 1 | 11 1.5|
Bile Duct, Hyperplasia | 2 2 | 15 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 5| 3| 7| 6| 4| 6| 6| 6| 6| 6| | |
DAY ON TEST | 9| 6| 1| 6| 6| 7| 0| 1| 3| 9| | |
| 5| 1| 0| 7| 0| 6| 6| 0| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hepatocyte, Degeneration, Cystic | 2 | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Inflammation, Acute, Focal | | 1 2.0|
Fat, Necrosis, Focal | | 3 2.3|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Atrophy, Focal | 2 1 | 18 1.7|
Autolysis | 2 | 2 3.0|
Inflammation, Focal, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Duct, Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Autolysis | | 1 2.0|
Cyst Epithelial Inclusion | | 1 4.0|
Hyperplasia | 1 1 2 1 2 | 35 1.4|
Inflammation, Acute | | 4 1.3|
Mineralization | | 2 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Autolysis | | 1 2.0|
Hyperplasia | | 1 1.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | 2 | 5 1.8|
Necrosis | 1 | 5 1.4|
Ulcer | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + | 42 |
Mineralization | | 2 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Inflammation, Chronic | 1 2 2 2 1 3 2 2 | 48 1.9|
Mineralization | 3 2 | 14 1.9|
Atrium Left, Thrombosis | | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 5| 3| 7| 6| 4| 6| 6| 6| 6| 6| | |
DAY ON TEST | 9| 6| 1| 6| 6| 7| 0| 1| 3| 9| | |
| 5| 1| 0| 7| 0| 6| 6| 0| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Congestion | | 2 2.0|
Hyperplasia, Focal | 1 | 8 1.3|
Hypertrophy, Focal | 1 | 1 1.0|
Inflammation, Chronic, Multifocal | | 1 2.0|
Mineralization, Multifocal | | 1 2.0|
Vacuolization Cytoplasmic | 1 1 1 3 | 10 1.5|
Capsule, Ectopic Tissue | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Hyperplasia, Focal | 1 1 | 6 1.0|
Bilateral, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
Autolysis | | 1 4.0|
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + | 49 |
Hyperplasia | 1 2 | 19 1.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 50 |
Pars Distalis, Angiectasis | | 1 1.0|
Pars Distalis, Hyperplasia | 1 | 6 1.5|
Pars Nervosa, Cyst | | 1 1.0|
Pars Nervosa, Inflammation, | | |
Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | | 1 1.0|
Follicle, Cyst | | 2 1.5|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 50 |
Duct, Epithelium, Degeneration | | 2 2.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 48 |
Inflammation, Acute | 2 1 | 9 1.1|
Inflammation, Chronic | 1 | 8 1.4|
Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 50 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 5| 3| 7| 6| 4| 6| 6| 6| 6| 6| | |
DAY ON TEST | 9| 6| 1| 6| 6| 7| 0| 1| 3| 9| | |
| 5| 1| 0| 7| 0| 6| 6| 0| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 50 |
Atrophy | | 1 4.0|
Bilateral, Atrophy | | 2 2.5|
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 1 2.0|
Interstitial Cell, Hyperplasia | 1 | 8 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Congestion | 3 | 1 3.0|
Depletion Cellular, Focal | | 2 2.5|
Myelofibrosis | 4 | 1 4.0|
Myeloid Cell, Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 49 |
Iliac, Hyperplasia | | 1 1.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia | | 1 1.0|
Renal, Hemorrhage | | 1 1.0|
Renal, Hyperplasia | | 1 1.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 44 |
Congestion | | 1 1.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Atrophy, Focal | | 1 2.0|
Fibrosis | | 2 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 2 2.5|
Necrosis, Focal | | 1 2.0|
Capsule, Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + I + + | 45 |
Autolysis | 3 | 1 3.0|
Cyst | | 1 2.0|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 5| 3| 7| 6| 4| 6| 6| 6| 6| 6| | |
DAY ON TEST | 9| 6| 1| 6| 6| 7| 0| 1| 3| 9| | |
| 5| 1| 0| 7| 0| 6| 6| 0| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + | 45 |
Hyperplasia | | 1 1.0|
Duct, Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Hyperkeratosis | 3 | 1 3.0|
Face, Inflammation, Acute | 2 | 4 1.3|
Tail, Hemorrhage | | 1 2.0|
Tail, Subcutaneous Tissue, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
Fibrous Osteodystrophy | 3 2 2 2 | 21 2.2|
Osteomalacia | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation, Acute, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | | 5 2.2|
Fibrosis, Focal | | 1 1.0|
Hemorrhage | | 5 1.8|
Inflammation, Acute, Multifocal | | 1 2.0|
Inflammation, Chronic | | 3 2.0|
Inflammation, Granulomatous | | 1 1.0|
Necrosis, Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 5 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Autolysis | 2 | 6 1.8|
Foreign Body | | 2 1.0|
Fungus | | 1 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05031-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MERCURIC CHLORIDE Date: 04/28/97
Route: GAVAGE Time: 16:06:46
__________________________________________________________________________________________________________________________________
| 5| 3| 7| 6| 4| 6| 6| 6| 6| 6| | |
DAY ON TEST | 9| 6| 1| 6| 6| 7| 0| 1| 3| 9| | |
| 5| 1| 0| 7| 0| 6| 6| 0| 8| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
5 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Inflammation, Acute | | 2 1.5|
Mucosa, Inflammation, Chronic Active | 1 4 | 16 1.9|
Nasolacrimal Duct, Cyst | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | 1 1 | 3 1.3|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
Inflammation, Acute | | 2 1.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Congestion | | 1 2.0|
Mineralization | 2 | 3 2.0|
Nephropathy | 4 4 4 4 4 3 3 4 | 48 3.5|
Cortex, Cyst | | 4 2.0|
Renal Tubule, Hyperplasia, Cystic | | 1 1.0|
Renal Tubule, Hyperplasia | 2 | 4 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
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---------- END OF REPORT ----------
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