TDMS Study 05031-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/04/94
EXP: 05031 MERCURIC CHLORIDE TIME: 17:46:49
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60173
CONT: CAS: 7487-94-7
PATHOLOGIST: P. HILDEBRANDT S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/04/94
EXP: 05031 MERCURIC CHLORIDE TIME: 17:46:49
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60173
CONT: CAS: 7487-94-7
PATHOLOGIST: P. HILDEBRANDT S. EUSTIS
MERCURIC CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 24 CENSORED DEATHS 10 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 279 480 506 546 551 565 577 586 601 609 |
| 632 638 656 657 672 683 692 703 706 707 |
| 710 715 715 715 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 40 CENSORED DEATHS 10 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 92 149 156 175 277 291 333 375 385 398 |
| 519 523 523 544 586 600 608 614 620 621 |
| 627 636 651 664 666 666 666 667 669 671 |
| 680 680 685 690 691 693 695 697 703 711 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 45 CENSORED DEATHS 10 TERMINAL 5 |
| |
| UNCENSORED DEATHS |
| 173 361 363 411 470 490 507 526 554 565 |
| 569 573 573 573 586 595 595 599 606 610 |
| 619 621 623 633 633 638 638 644 644 652 |
| 658 664 667 667 667 669 676 676 687 692 |
| 703 710 715 719 719 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
==================================================================================
MERCURIC CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.3 98.3 96.3 94.3 82.3 72.2 52.2 |
| | |
| | |
|2.5MG/KG | 100.0 93.3 93.3 88.3 83.3 83.3 75.0 70.8 54.2 20.8 |
| | |
| | |
|5 MG/KG | 100.0 98.3 98.3 95.0 93.3 91.3 85.2 64.9 36.5 10.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 2.5MG/KG 5 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.2% 20.8% 10.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 620.9 547.4 598.5 |
|NATURAL DEATHS (C) | (20.7) (28.7) (16.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 640.9 563.1 586.3 |
|(STANDARD ERROR) | (14.8) (21.7) (14.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MERCURIC CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 10 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 531 572 573 576 590 614 621 641 643 655 |
| 656 657 659 666 698 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5MG/KG |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 21 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 84 277 285 437 523 552 565 571 582 595 |
| 601 609 614 629 647 656 684 687 708 717 |
| 717 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5.0MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 42 87 106 313 428 515 518 580 581 586 |
| 593 623 626 629 631 636 665 692 692 700 |
| CENSORED DEATHS |
| 460 460 460 460 460 460 460 460 460 460 |
| |
==================================================================================
MERCURIC CHLORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 90.0 74.0 70.0 |
| | |
| | |
|2.5MG/KG | 98.3 98.3 98.3 94.9 94.9 93.2 91.1 78.7 68.4 58.0 |
| | |
| | |
|5.0MG/KG | 96.7 95.0 95.0 93.3 93.3 91.7 87.6 79.4 67.2 61.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 2.5MG/KG 5.0MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 58.0% 61.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.271 P=0.210 P=0.305 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 623.5 559.0 512.2 |
|NATURAL DEATHS (C) | (11.9) (35.6) (46.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 657.8 622.9 611.9 |
|(STANDARD ERROR) | (13.2) (18.7) (21.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MERCURIC CHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
2.5MG/KG = 2
5 MG/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 2 22 3 1 3 1 1
| 2 2 3 3 1 1
| 2 2 2 3 3 3 11
90 + 2 2 3 3 1 1
| 2 2 2 3 3 1 11
| 2 2 3 3 1 1
| 2 2 33 11
80 + 33 1 1
| 2 2 11 1
P | 2 2
E | 3 2 2 1 1
R 70 + 3 3222 1 1
C | 33 22 11
E | 33 1 1
N | 3322
T 60 + 3322 11
| 2 2 2 11
S | 3 3 22
U | 1 1
R 50 + 33
V |
I |
V | 3 3 2 2
A 40 +
L | 3 33
| 22
|
30 + 22
| 33
| 3 322
| 22
20 + 3 32 2
| 33
| 33
|
10 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.
MERCURIC CHLORIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
2.5MG/KG = 2
5.0MG/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 23 2
| 1 1
| 3 3 22
95 + 3 2 3 2
| 3 32 2 11
| 1 1
| 3 3 2 2
90 + 1 1
| 2 2
P | 3 223 11
E | 1 1
R 85 + 2 2
C | 33
E | 2 2 1 1
N | 3 22
T 80 + 3 3
| 22
S | 33
U | 22 1 1
R 75 + 2 2
V | 33 11
I | 2 2 1 1
V |
A 70 + 22 1 1
L | 3 2 3 2
| 3 3
| 22
65 +
| 23 2
| 22
| 3 3
60 +
|
| 2 2
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.