TDMS Study 05033-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
QUERCETIN
NTP Experiment-Test: 05033-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
Facility: TSI Mason Research
Chemical CAS #: 117-39-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 20 20 20
Early Deaths
Moribund 19 18 13 19
Dead 1 4 2 3
Survivors
Terminal Sacrifice 29 28 35 27
Moribund 1
Dead 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (11) (8) (48)
Necrosis, Acute, Coagulative 1 (2%)
Parasite Metazoan 2 (4%) 4 (8%)
Lymphoid Tissue, Hypoplasia 1 (9%)
Intestine Large, Colon (50) (11) (7) (48)
Parasite Metazoan 9 (18%) 1 (9%) 2 (29%) 5 (10%)
Intestine Large, Rectum (48) (11) (7) (47)
Parasite Metazoan 5 (10%) 2 (4%)
Intestine Small, Duodenum (50) (48) (50) (49)
Autolysis 1 (2%)
Epithelium, Pigmentation 1 (2%)
Intestine Small, Ileum (49) (48) (49) (49)
Epithelium, Pigmentation 19 (39%) 32 (65%)
Serosa, Fibrosis 1 (2%)
Intestine Small, Jejunum (50) (47) (49) (49)
Autolysis 1 (2%) 1 (2%)
Epithelium, Pigmentation 3 (6%) 20 (41%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 5 (10%) 1 (2%)
Basophilic Focus 40 (80%) 38 (76%) 41 (82%) 39 (78%)
Clear Cell Focus 4 (8%) 4 (8%) 4 (8%) 2 (4%)
Cyst 2 (4%)
Cyst Multilocular 1 (2%)
Cytoplasmic Alteration 4 (8%) 1 (2%)
Degeneration 1 (2%) 1 (2%)
Developmental Malformation 3 (6%) 2 (4%)
Eosinophilic Focus 3 (6%) 3 (6%)
Fatty Change 14 (28%) 12 (24%) 12 (24%) 7 (14%)
Fibrosis, Focal 1 (2%)
Granuloma 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 5 (10%)
Infarct 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 3 (6%) 3 (6%)
Inflammation, Chronic, Granulomatous 12 (24%) 17 (34%) 10 (20%) 8 (16%)
Inflammation, Chronic Active 2 (4%) 2 (4%) 2 (4%) 7 (14%)
Mixed Cell Focus 4 (8%) 7 (14%) 4 (8%) 1 (2%)
Necrosis, Coagulative 4 (8%) 5 (10%) 5 (10%) 8 (16%)
Pigmentation 1 (2%) 1 (2%) 1 (2%)
Bile Duct, Cyst Multilocular 1 (2%)
Bile Duct, Hyperplasia 17 (34%) 14 (28%) 17 (34%) 15 (30%)
Centrilobular, Necrosis, Coagulative 1 (2%)
Serosa, Fibrosis 1 (2%)
Serosa, Hemorrhage 1 (2%)
Mesentery (2) (6) (2) (1)
Fibrosis 6 (100%) 1 (50%)
Inflammation, Chronic 3 (50%)
Inflammation, Chronic, Granulomatous 1 (50%) 1 (17%) 1 (50%)
Inflammation, Chronic Active 2 (33%)
Mineralization 1 (17%) 1 (50%)
Necrosis, Coagulative 2 (100%) 3 (50%)
Pigmentation 1 (50%)
Pancreas (50) (49) (50) (50)
Atrophy 21 (42%) 21 (43%) 21 (42%) 15 (30%)
Cytoplasmic Alteration 2 (4%) 4 (8%) 2 (4%)
Ectopic Liver 1 (2%)
Inflammation, Chronic 17 (34%) 22 (45%) 22 (44%) 17 (34%)
Pigmentation 1 (2%)
Artery, Hyperplasia 1 (2%)
Artery, Perivascular, Inflammation, Chronic,
Necrotizing 1 (2%)
Duct, Dilatation 1 (2%)
Stomach, Forestomach (49) (50) (50) (47)
Acanthosis 3 (6%) 3 (6%) 3 (6%) 7 (15%)
Edema 1 (2%) 1 (2%) 1 (2%)
Erosion 1 (2%)
Hyperkeratosis 3 (6%) 2 (4%) 1 (2%) 7 (15%)
Hyperplasia, Basal Cell 4 (8%) 2 (4%) 3 (6%) 5 (11%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 3 (6%) 3 (6%) 2 (4%)
Inflammation, Chronic Active, Necrotizing 1 (2%)
Necrosis, Coagulative 1 (2%)
Ulcer 1 (2%) 1 (2%) 2 (4%)
Artery, Mineralization 1 (2%)
Artery, Muscularis, Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Muscularis, Mineralization 1 (2%) 3 (6%)
Submucosa, Mineralization 1 (2%)
Stomach, Glandular (50) (49) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Edema 1 (2%)
Inflammation, Chronic Active 3 (6%) 1 (2%) 1 (2%)
Ulcer 1 (2%)
Artery, Mineralization 3 (6%) 1 (2%)
Epithelium, Pigmentation 8 (16%) 38 (76%)
Mucosa, Dilatation 6 (12%) 5 (10%) 4 (8%)
Muscularis, Developmental Malformation 1 (2%)
Muscularis, Mineralization 1 (2%) 2 (4%) 6 (12%) 4 (8%)
Tongue (29) (43) (43) (39)
Hemorrhage 2 (5%) 1 (2%)
Inflammation, Chronic 7 (24%) 7 (16%) 12 (28%) 6 (15%)
Arteriole, Necrosis, Fibrinoid 2 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (13) (7) (50)
Cardiomyopathy 47 (94%) 9 (69%) 3 (43%) 47 (94%)
Atrium Left, Thrombosis 1 (2%)
Coronary Artery, Inflammation, Chronic Active 1 (2%)
Coronary Artery, Inflammation, Chronic
Active, Necrotizing 1 (2%)
Coronary Artery, Necrosis, Fibrinoid 1 (2%)
Epicardium, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (13) (13) (50)
Angiectasis 28 (56%) 2 (15%) 2 (15%) 26 (52%)
Atrophy 1 (8%)
Congestion 1 (2%) 1 (8%)
Degeneration, Fatty 1 (2%)
Hyperplasia 16 (32%) 2 (15%) 15 (30%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Pigmentation 1 (8%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 28 (56%) 8 (62%) 3 (23%) 24 (48%)
Adrenal Gland, Medulla (49) (13) (12) (50)
Angiectasis 5 (10%) 1 (8%)
Hyperplasia 3 (6%) 1 (8%) 4 (8%)
Necrosis, Coagulative 1 (2%)
Islets, Pancreatic (44) (15) (8) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Ectopic Tissue 1 (2%)
Hyperplasia 1 (7%)
Parathyroid Gland (40) (39) (36) (43)
Cyst 1 (3%)
Hyperplasia 1 (3%) 1 (3%)
Pituitary Gland (50) (49) (50) (49)
Angiectasis 1 (2%)
Hyperplasia 2 (4%)
Pars Distalis, Angiectasis 14 (28%) 11 (22%) 12 (24%) 8 (16%)
Pars Distalis, Cyst 26 (52%) 21 (43%) 23 (46%) 28 (57%)
Pars Distalis, Cyst, Multiple 1 (2%) 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 18 (36%) 23 (47%) 18 (36%) 13 (27%)
Pars Distalis, Infiltration Cellular,
Histiocyte 1 (2%)
Pars Distalis, Pigmentation 1 (2%) 3 (6%) 3 (6%)
Pars Intermedia, Angiectasis 5 (10%) 6 (12%) 4 (8%) 6 (12%)
Pars Intermedia, Cyst 2 (4%) 7 (14%) 6 (12%)
Pars Intermedia, Pigmentation 1 (2%)
Pars Nervosa, Angiectasis 1 (2%) 1 (2%)
Pars Nervosa, Cyst 1 (2%)
Thyroid Gland (50) (43) (47) (50)
Ultimobranchial Cyst 1 (2%) 3 (6%)
C-Cell, Hyperplasia 38 (76%) 37 (86%) 40 (85%) 37 (74%)
Follicle, Cyst 2 (4%) 4 (8%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (14) (20) (14) (12)
Abscess 1 (7%) 2 (10%) 1 (8%)
Cyst 3 (21%) 2 (10%) 1 (7%)
Hyperplasia 2 (14%) 1 (5%)
Inflammation, Acute 1 (5%) 1 (7%)
Inflammation, Chronic 6 (43%) 10 (50%) 4 (29%) 4 (33%)
Inflammation, Chronic Active 3 (21%) 2 (10%) 3 (21%) 1 (8%)
Ovary (50) (17) (15) (48)
Congestion 1 (7%)
Cyst 3 (6%) 2 (4%)
Periovarian Tissue, Cyst 5 (10%) 3 (18%) 9 (60%) 5 (10%)
Uterus (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Cyst 3 (6%)
Hydrometra 11 (22%) 9 (18%) 5 (10%) 14 (28%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Pigmentation 1 (2%)
Cervix, Cyst 1 (2%)
Cervix, Inflammation, Chronic 1 (2%)
Endometrium, Hyperplasia 6 (12%) 7 (14%) 8 (16%) 7 (14%)
Lumen, Exudate 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (48) (25) (17) (49)
Deep Cervical, Hyperplasia, Plasma Cell 1 (2%)
Lumbar, Infiltration Cellular, Histiocyte 1 (2%)
Lumbar, Pigmentation 1 (2%)
Mediastinal, Depletion Lymphoid 1 (2%)
Mediastinal, Hemorrhage 8 (17%) 3 (12%) 3 (18%) 7 (14%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Mediastinal, Necrosis, Coagulative 1 (2%)
Mediastinal, Pigmentation 2 (4%) 1 (4%) 1 (6%) 2 (4%)
Pancreatic, Ectasia 1 (6%) 1 (2%)
Pancreatic, Hemorrhage 1 (2%) 2 (4%)
Pancreatic, Infiltration Cellular, Histiocyte 2 (12%) 2 (4%)
Pancreatic, Pigmentation 2 (12%) 3 (6%)
Renal, Ectasia 2 (8%)
Renal, Hemorrhage 2 (4%) 1 (4%) 2 (12%) 3 (6%)
Renal, Infiltration Cellular 1 (2%)
Renal, Infiltration Cellular, Histiocyte 1 (2%) 3 (12%) 2 (12%) 4 (8%)
Renal, Pigmentation 1 (2%) 4 (16%) 2 (12%) 3 (6%)
Lymph Node, Mandibular (46) (19) (10) (46)
Congestion 1 (5%)
Ectasia 11 (24%) 5 (26%) 6 (13%)
Hemorrhage 22 (48%) 6 (32%) 3 (30%) 17 (37%)
Hyperplasia, Plasma Cell 2 (4%)
Infiltration Cellular, Histiocyte 2 (11%) 1 (10%) 2 (4%)
Necrosis, Coagulative 1 (10%)
Pigmentation 1 (2%) 2 (11%) 2 (4%)
Lymph Node, Mesenteric (9) (14) (12) (9)
Angiectasis 1 (8%)
Ectasia 1 (8%) 1 (11%)
Hemorrhage 1 (11%) 2 (17%)
Infiltration Cellular, Histiocyte 8 (89%) 14 (100%) 10 (83%) 7 (78%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Necrosis, Coagulative 1 (11%)
Pigmentation 8 (89%) 14 (100%) 8 (67%) 7 (78%)
Thrombosis 1 (8%)
Spleen (50) (23) (20) (50)
Depletion Lymphoid 5 (10%) 5 (22%) 4 (20%) 9 (18%)
Fibrosis 1 (4%)
Hematopoietic Cell Proliferation 2 (9%) 1 (5%) 1 (2%)
Hyperplasia, Lymphoid 3 (15%)
Inflammation, Chronic, Granulomatous 2 (9%) 3 (15%) 1 (2%)
Necrosis 1 (2%)
Pigmentation 1 (2%)
Thrombosis 1 (2%) 1 (4%)
Capsule, Hyperplasia 1 (2%)
Thymus (8) (10) (7) (9)
Depletion Lymphoid 5 (63%) 7 (70%) 1 (14%) 7 (78%)
Hemorrhage 1 (10%) 1 (14%)
Necrosis, Coagulative 1 (11%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (36) (36) (24) (22)
Galactocele 1 (3%) 1 (4%) 1 (5%)
Hyperplasia 13 (36%) 20 (56%) 13 (54%) 13 (59%)
Hyperplasia, Cystic 1 (3%)
Skin (11) (15) (8) (11)
Inflammation, Acute, Necrotizing 1 (13%)
Inflammation, Chronic 1 (7%)
Subcutaneous Tissue, Edema 1 (9%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (15) (8) (50)
Hemorrhage 2 (4%)
Hydrocephalus 2 (4%) 1 (7%) 1 (13%) 1 (2%)
Meninges, Hemorrhage 2 (13%)
Spinal Cord (1) (2) (2)
Hemorrhage 1 (50%) 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (20) (20) (50)
Crystals 1 (2%)
Foreign Body 1 (5%)
Hemorrhage 4 (8%) 3 (15%) 2 (10%) 4 (8%)
Infiltration Cellular, Histiocyte 14 (28%) 5 (25%) 3 (15%) 18 (36%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (5%) 1 (2%)
Leukocytosis 1 (5%)
Metaplasia, Osseous 1 (2%)
Pigmentation 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (5%) 2 (10%) 1 (2%)
Artery, Mineralization 24 (48%) 3 (15%) 6 (30%) 14 (28%)
Nose (7) (12) (7) (10)
Congestion 1 (8%)
Capillary, Submucosa, Thrombosis 1 (10%)
Glands, Inflammation, Acute 1 (14%) 1 (10%)
Lumen, Inflammation, Acute 1 (8%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (6) (8) (6) (5)
Cataract 5 (83%) 2 (25%) 3 (50%) 1 (20%)
Synechia 1 (17%) 3 (38%) 3 (50%)
Cornea, Fibrosis 2 (25%)
Retina, Degeneration 5 (83%) 6 (75%) 4 (67%) 2 (40%)
Sclera, Metaplasia, Osseous 1 (20%)
Sclera, Mineralization 1 (17%)
Harderian Gland (4) (2) (2)
Hemorrhage 1 (25%) 1 (50%)
Inflammation, Acute 1 (25%)
Inflammation, Chronic 3 (75%) 1 (50%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (50) (50)
Autolysis 1 (2%) 1 (2%)
Congestion 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Nephropathy 48 (98%) 48 (98%) 50 (100%) 48 (96%)
Artery, Fibrosis 1 (2%)
Artery, Thrombosis 1 (2%)
Collecting Tubule, Mineralization 1 (2%)
Papilla, Necrosis, Coagulative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Proximal Convoluted Renal Tubule,
Degeneration, Hyaline 1 (2%)
Proximal Convoluted Renal Tubule,
Inflammation, Acute 4 (8%)
Proximal Convoluted Renal Tubule,
Pigmentation 1 (2%) 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%) 3 (6%) 1 (2%)
Renal Tubule, Hyperplasia, Cystic 1 (2%)
Transitional Epithelium, Hyperplasia 7 (14%) 9 (18%) 5 (10%) 4 (8%)
Urinary Bladder (50) (49) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 4 (8%)
Subserosa, Mineralization 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 20 20 20
Early Deaths
Moribund 21 15 22 21
Dead 3 7 3 6
Survivors
Moribund 1 1
Terminal Sacrifice 25 27 22 19
Dead 1 1 2 3
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (11) (13) (46)
Parasite Metazoan 4 (8%) 1 (9%) 4 (9%)
Intestine Large, Colon (49) (12) (11) (47)
Parasite Metazoan 9 (18%) 2 (17%) 1 (9%) 3 (6%)
Epithelium, Pigmentation 1 (2%)
Intestine Large, Rectum (49) (11) (10) (46)
Parasite Metazoan 3 (6%) 4 (9%)
Intestine Small, Duodenum (48) (47) (48) (46)
Epithelium, Pigmentation 3 (7%)
Intestine Small, Ileum (47) (47) (48) (45)
Necrosis, Coagulative 1 (2%)
Epithelium, Pigmentation 1 (2%) 15 (31%) 28 (62%)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Small, Jejunum (48) (44) (43) (44)
Autolysis 1 (2%)
Epithelium, Pigmentation 2 (5%) 19 (43%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 2 (4%) 2 (4%)
Basophilic Focus 16 (32%) 17 (34%) 18 (36%) 20 (40%)
Clear Cell Focus 7 (14%) 10 (20%) 5 (10%) 8 (16%)
Congestion 1 (2%)
Cyst 1 (2%)
Cyst Multilocular 1 (2%)
Cytoplasmic Alteration 2 (4%) 3 (6%) 1 (2%)
Degeneration 4 (8%) 2 (4%) 1 (2%)
Degeneration, Cystic 6 (12%) 5 (10%) 9 (18%) 2 (4%)
Eosinophilic Focus 9 (18%) 5 (10%) 7 (14%) 3 (6%)
Fatty Change 5 (10%) 12 (24%) 5 (10%) 8 (16%)
Fibrosis 2 (4%)
Hemorrhage 1 (2%) 4 (8%) 3 (6%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatodiaphragmatic Nodule 2 (4%) 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%) 2 (4%)
Inflammation, Chronic 24 (48%) 30 (60%) 26 (52%) 23 (46%)
Mixed Cell Focus 3 (6%) 4 (8%) 4 (8%) 3 (6%)
Mixed Cell Focus, Multiple 1 (2%)
Necrosis, Coagulative 7 (14%) 8 (16%) 9 (18%) 7 (14%)
Thrombosis 1 (2%) 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 46 (92%) 48 (96%) 47 (94%) 30 (60%)
Centrilobular, Necrosis, Coagulative 1 (2%) 1 (2%) 2 (4%)
Mesentery (7) (6) (5) (5)
Fibrosis 1 (17%) 1 (20%)
Inflammation, Chronic 2 (29%) 1 (20%)
Inflammation, Chronic, Granulomatous 2 (40%)
Mineralization 1 (20%) 1 (20%)
Necrosis, Coagulative 1 (14%) 2 (33%) 1 (20%) 1 (20%)
Pigmentation 1 (14%) 1 (20%)
Pancreas (50) (50) (50) (47)
Atrophy 23 (46%) 26 (52%) 23 (46%) 24 (51%)
Cyst 1 (2%) 1 (2%)
Cytoplasmic Alteration 2 (4%) 3 (6%)
Ectopic Liver 1 (2%) 1 (2%)
Fibrosis 2 (4%)
Hyperplasia 3 (6%) 3 (6%) 1 (2%)
Inflammation, Chronic 32 (64%) 28 (56%) 30 (60%) 34 (72%)
Necrosis, Coagulative 1 (2%)
Pigmentation 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Artery, Fibrosis 3 (6%)
Artery, Inflammation, Chronic Active,
Necrotizing 1 (2%) 2 (4%)
Artery, Mineralization 1 (2%)
Duct, Dilatation 1 (2%) 1 (2%)
Perivascular, Inflammation, Chronic 3 (6%)
Serosa, Hyperplasia 1 (2%)
Salivary Glands (16) (14) (12) (10)
Parotid Gland, Vacuolization Cytoplasmic 1 (8%)
Stomach, Forestomach (49) (49) (49) (46)
Acanthosis 6 (12%) 2 (4%) 5 (11%)
Edema 1 (2%)
Fibrosis 1 (2%)
Hyperkeratosis 3 (6%) 2 (4%) 5 (11%)
Hyperplasia, Basal Cell 3 (6%) 9 (18%) 8 (16%) 2 (4%)
Hyperplasia, Pseudoepitheliomatous 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 3 (7%)
Mineralization 3 (6%) 2 (4%)
Ulcer 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Muscularis, Pigmentation 1 (2%)
Stomach, Glandular (50) (50) (49) (48)
Edema 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Epithelium, Pigmentation 3 (6%) 34 (71%)
Mucosa, Mineralization 3 (6%) 7 (15%)
Muscularis, Mineralization 1 (2%) 1 (2%)
Submucosa, Fibrosis 1 (2%)
Tongue (45) (48) (47) (44)
Hemorrhage 1 (2%)
Inflammation, Acute, Necrotizing 1 (2%)
Metaplasia, Osseous 1 (2%)
Artery, Mineralization 1 (2%) 4 (9%)
Artery, Endothelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1) (2)
Aorta, Mineralization 1 (100%) 1 (100%) 2 (100%)
Heart (50) (18) (18) (50)
Cardiomyopathy 48 (96%) 14 (78%) 15 (83%) 49 (98%)
Cytomegaly 1 (6%)
Edema 1 (2%)
Inflammation, Chronic 1 (2%)
Metaplasia, Osseous 2 (11%) 1 (2%)
Mineralization 2 (4%)
Thrombosis 6 (12%) 1 (6%) 5 (28%) 1 (2%)
Artery, Mineralization 3 (6%)
Coronary Artery, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (18) (21) (49)
Angiectasis 6 (12%) 1 (6%) 2 (10%) 8 (16%)
Atrophy 1 (2%)
Congestion 1 (2%) 3 (17%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (5%)
Hyperplasia 10 (20%) 2 (11%) 1 (5%) 14 (29%)
Necrosis, Coagulative 2 (11%) 1 (5%) 1 (2%)
Vacuolization Cytoplasmic 26 (52%) 12 (67%) 8 (38%) 27 (55%)
Adrenal Gland, Medulla (50) (18) (21) (49)
Angiectasis 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Atrophy 1 (2%)
Congestion 2 (4%)
Hyperplasia 22 (44%) 2 (11%) 3 (14%) 21 (43%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Islets, Pancreatic (47) (15) (13) (41)
Hyperplasia 1 (2%) 1 (7%) 1 (2%)
Parathyroid Gland (43) (45) (43) (43)
Hyperplasia 1 (2%) 6 (13%) 6 (14%) 17 (40%)
Pituitary Gland (46) (49) (50) (48)
Autolysis 1 (2%) 3 (6%)
Hemorrhage 1 (2%)
Pars Distalis, Angiectasis 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Autolysis 1 (2%) 2 (4%)
Pars Distalis, Congestion 1 (2%)
Pars Distalis, Cyst 7 (15%) 6 (12%) 4 (8%) 7 (15%)
Pars Distalis, Hyperplasia 18 (39%) 24 (49%) 17 (34%) 20 (42%)
Pars Distalis, Necrosis 1 (2%)
Pars Distalis, Pigmentation 5 (10%) 1 (2%)
Pars Intermedia, Angiectasis 2 (4%) 3 (6%)
Pars Intermedia, Crystals 1 (2%)
Pars Intermedia, Cyst 6 (13%) 10 (20%) 14 (28%) 7 (15%)
Pars Intermedia, Ectopic Tissue 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Pars Nervosa, Cyst 1 (2%)
Pars Nervosa, Ectopic Tissue 1 (2%)
Pars Nervosa, Hyperplasia 1 (2%)
Rathke's Cleft, Cyst 1 (2%)
Thyroid Gland (50) (17) (22) (49)
Congestion 1 (6%)
Inflammation, Acute 1 (2%)
Ultimobranchial Cyst 2 (4%)
C-Cell, Hyperplasia 17 (34%) 3 (18%) 6 (27%) 16 (33%)
Follicle, Pigmentation 1 (2%) 1 (5%) 6 (12%)
Follicular Cell, Cyst 3 (6%)
Follicular Cell, Hyperplasia 2 (4%) 1 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2) (1) (2)
Adventitia, Inflammation, Chronic Active 1 (50%)
Preputial Gland (13) (22) (19) (15)
Abscess 5 (23%) 2 (11%)
Cyst 1 (8%)
Hyperplasia 1 (7%)
Inflammation, Chronic 12 (92%) 19 (86%) 13 (68%) 13 (87%)
Duct, Dilatation 1 (5%)
Prostate (49) (14) (12) (48)
Fibrosis 1 (2%)
Hemorrhage 1 (7%)
Inflammation, Acute 1 (7%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 25 (51%) 9 (64%) 10 (83%) 30 (63%)
Epithelium, Hyperplasia 2 (4%) 2 (4%)
Seminal Vesicle (50) (22) (23) (49)
Atrophy 36 (72%) 9 (41%) 9 (39%) 39 (80%)
Testes (50) (46) (48) (50)
Infarct 1 (2%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Interstitial Cell, Hyperplasia 34 (68%) 35 (76%) 41 (85%) 44 (88%)
Seminiferous Tubule, Atrophy 44 (88%) 44 (96%) 43 (90%) 46 (92%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (11) (12) (12) (9)
Fibrosis 1 (11%)
Lymph Node (49) (29) (26) (50)
Angiectasis 1 (3%)
Artery, Pancreatic, Thrombosis 1 (4%)
Inguinal, Ectasia 1 (3%)
Lumbar, Ectasia 1 (2%) 3 (10%)
Lumbar, Hemorrhage 1 (2%) 1 (3%) 1 (4%)
Lumbar, Hyperplasia, Plasma Cell 1 (4%)
Lumbar, Infiltration Cellular, Histiocyte 1 (3%)
Lumbar, Inflammation, Acute 1 (3%)
Lumbar, Pigmentation 1 (3%)
Mediastinal, Depletion Lymphoid 1 (2%)
Mediastinal, Ectasia 2 (7%) 3 (12%)
Mediastinal, Hemorrhage 6 (12%) 4 (14%) 3 (12%) 6 (12%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (4%)
Mediastinal, Pigmentation 1 (2%) 5 (17%) 2 (8%) 1 (2%)
Pancreatic, Ectasia 1 (2%)
Pancreatic, Hemorrhage 3 (6%) 2 (7%) 2 (8%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pancreatic, Hyperplasia, Plasma Cell 1 (2%)
Pancreatic, Infiltration Cellular, Histiocyte 3 (6%) 5 (17%) 2 (8%)
Pancreatic, Pigmentation 3 (6%) 2 (7%) 3 (12%)
Renal, Ectasia 1 (2%) 2 (7%) 2 (8%) 1 (2%)
Renal, Fibrosis 1 (3%)
Renal, Hemorrhage 5 (10%) 4 (14%) 5 (19%) 5 (10%)
Renal, Hyperplasia, Lymphoid 1 (4%)
Renal, Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Renal, Infiltration Cellular, Histiocyte 4 (14%) 2 (8%) 2 (4%)
Renal, Pigmentation 6 (12%) 6 (21%) 3 (12%) 5 (10%)
Lymph Node, Mandibular (46) (18) (15) (47)
Angiectasis 1 (2%)
Congestion 1 (6%) 1 (2%)
Depletion Lymphoid 1 (2%)
Ectasia 3 (7%) 1 (6%) 3 (20%) 10 (21%)
Hemorrhage 12 (26%) 4 (22%) 2 (13%) 12 (26%)
Hyperplasia, Plasma Cell 3 (7%) 1 (2%)
Infiltration Cellular, Histiocyte 3 (6%)
Pigmentation 2 (4%)
Lymph Node, Mesenteric (22) (14) (17) (19)
Ectasia 1 (6%) 12 (63%)
Hemorrhage 3 (14%) 1 (7%) 4 (24%) 3 (16%)
Hyperplasia, Plasma Cell 1 (5%)
Infiltration Cellular, Histiocyte 11 (50%) 10 (71%) 14 (82%) 9 (47%)
Pigmentation 9 (41%) 9 (64%) 10 (59%) 8 (42%)
Spleen (50) (25) (38) (50)
Congestion 1 (2%) 2 (8%) 1 (3%)
Depletion Lymphoid 9 (18%) 14 (56%) 13 (34%) 9 (18%)
Fibrosis 6 (12%) 5 (20%) 8 (21%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (8%) 1 (3%) 3 (6%)
Hyperplasia, Lymphoid 1 (3%)
Infarct 2 (4%)
Necrosis, Coagulative 1 (2%)
Pigmentation 1 (2%) 1 (3%)
Thrombosis 1 (3%)
Thymus (14) (11) (13) (5)
Congestion 1 (8%)
Depletion Lymphoid 7 (50%) 5 (45%) 5 (38%) 5 (100%)
Hemorrhage 1 (7%) 1 (9%) 1 (8%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (13) (10) (14) (9)
Abscess 1 (10%)
Galactocele 1 (8%) 1 (10%) 1 (11%)
Hyperplasia 7 (54%) 9 (90%) 9 (64%) 6 (67%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Pigmentation 3 (30%) 3 (21%) 1 (11%)
Skin (20) (18) (19) (18)
Acanthosis 1 (5%) 1 (5%) 3 (17%)
Cyst Epithelial Inclusion 2 (10%) 3 (17%)
Fibrosis 1 (5%)
Hyperkeratosis 1 (5%) 1 (6%) 1 (5%) 3 (17%)
Hyperplasia, Basal Cell 1 (6%)
Inflammation, Acute, Necrotizing 1 (6%)
Subcutaneous Tissue, Abscess 1 (5%) 1 (6%)
Subcutaneous Tissue, Edema 1 (5%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (5%)
Subcutaneous Tissue, Inflammation,
Granulomatous 1 (5%) 1 (6%) 1 (6%)
Subcutaneous Tissue, Necrosis, Coagulative 1 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2)
Hindlimb, Mineralization 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (15) (12) (50)
Hemorrhage 2 (4%) 2 (13%) 2 (4%)
Cerebellum, Infarct 1 (2%)
Cerebrum, Degeneration, Focal 1 (8%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (28) (31) (50)
Congestion 1 (4%) 1 (3%) 1 (2%)
Edema 2 (6%) 1 (2%)
Hemorrhage 4 (8%) 6 (21%) 5 (16%) 1 (2%)
Infiltration Cellular, Histiocyte 31 (62%) 18 (64%) 18 (58%) 43 (86%)
Inflammation, Chronic Active 1 (3%)
Metaplasia, Osseous 1 (3%) 2 (4%)
Necrosis, Coagulative 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (14%) 2 (6%) 3 (6%)
Artery, Mineralization 34 (68%) 13 (46%) 17 (55%) 43 (86%)
Bronchiole, Epithelium, Hyperplasia 1 (3%) 1 (2%)
Nose (44) (48) (49) (49)
Foreign Body 1 (2%)
Metaplasia, Squamous 1 (2%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Glands, Inflammation, Acute 11 (25%) 11 (23%) 4 (8%) 5 (10%)
Lumen, Hemorrhage 1 (2%)
Lumen, Inflammation, Acute 2 (5%) 3 (6%) 9 (18%) 3 (6%)
Mucosa, Congestion 1 (2%)
Nasopharyngeal Duct, Inflammation, Acute 1 (2%)
Nasopharyngeal Duct, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (9) (6) (3)
Atrophy 1 (33%)
Synechia 1 (33%)
Artery, Mineralization 1 (17%)
Cornea, Fibrosis 1 (50%) 1 (11%) 1 (33%)
Cornea, Inflammation, Chronic 1 (11%)
Posterior Chamber, Inflammation, Chronic 1 (33%)
Retina, Degeneration 1 (50%) 1 (33%)
Sclera, Metaplasia, Osseous 1 (11%)
Harderian Gland (1) (1) (1)
Hyperplasia 1 (100%)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Autolysis 2 (4%)
Congestion 2 (4%) 2 (4%)
Cyst 2 (4%) 6 (12%) 1 (2%) 7 (14%)
Hemorrhage 1 (2%) 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Nephropathy 48 (96%) 50 (100%) 50 (100%) 49 (98%)
Artery, Inflammation, Chronic Active,
Necrotizing 1 (2%)
Collecting Tubule, Mineralization 1 (2%)
Interstitial Tissue, Inflammation, Acute 1 (2%)
Interstitial Tissue, Proximal Convoluted
Renal Tubule, Inflammation, Acute 1 (2%)
Proximal Convoluted Renal Tubule,
Mineralization 1 (2%) 2 (4%) 5 (10%)
Proximal Convoluted Renal Tubule, Necrosis 1 (2%) 1 (2%)
Proximal Convoluted Renal Tubule, Epithelium,
Pigmentation 5 (10%) 2 (4%) 3 (6%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 4 (8%)
Renal Tubule, Hyperplasia, Cystic 1 (2%) 1 (2%)
Transitional Epithelium, Hyperplasia 14 (28%) 9 (18%) 16 (32%) 27 (54%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Mineralization 1 (2%)
Urethra (1)
Calculus Micro Observation Only 1 (100%)
Urinary Bladder (50) (49) (49) (48)
Calculus Micro Observation Only 2 (4%) 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%)
Artery, Mineralization 1 (2%)
Serosa, Mineralization 1 (2%)
Submucosa, Hemorrhage 1 (2%)
Subserosa, Mineralization 1 (2%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Wall, Mucosa, Muscularis, Inflammation,
Acute, Diffuse, Necrotizing 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
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