TDMS Study 05033-01 Pathology Tables
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
Facility: TSI Mason Research
Chemical CAS #: 117-39-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|
| 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + M + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
Glandular, Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + |
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + M M + M |
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|
| 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma, Multiple | |
Pars Distalis, Leukemia Mononuclear | X |
Pars Distalis, Pars Intermedia, Pars | |
Nervosa, Leukemia Mononuclear | |
Pars Intermedia, Leukemia Mononuclear| |
Pars Nervosa, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + |
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + |
Granulosa Cell Tumor Benign | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Leiomyoma | |
Leukemia Mononuclear | |
Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Hemangioma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + + M |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + |
Adenocarcinoma | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|
| 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | X X X X X |
__________________________________________________________________________|
Skin | + + + + + + |
Subcutaneous Tissue, Carcinosarcoma, | |
Poorly Differentiated | X |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X X X |
Carcinosarcoma, Metastatic, Skin | X |
Leukemia Mononuclear | X X X X |
Mediastinum, Leukemia Mononuclear | |
Parenchyma, Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Fibrosarcoma | |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Zymbal's Gland | |
Adenoma | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|
| 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + M |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | + + + M + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + |
Glandular, Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | M M + + + M M + + + + + + + + I |
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|
| 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma, Multiple | |
Pars Distalis, Leukemia Mononuclear | X |
Pars Distalis, Pars Intermedia, Pars | |
Nervosa, Leukemia Mononuclear | X |
Pars Intermedia, Leukemia Mononuclear| X |
Pars Nervosa, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + |
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + |
Granulosa Cell Tumor Benign | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Leiomyoma | X |
Leukemia Mononuclear | X |
Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + |
__________________________________________________________________________|
Lymph Node | + + + M + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + M + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Hemangioma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + |
Adenocarcinoma | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|
| 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroadenoma | X X X X X X X X X X |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + + |
Subcutaneous Tissue, Carcinosarcoma, | |
Poorly Differentiated | |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Carcinosarcoma, Metastatic, Skin | |
Leukemia Mononuclear | X X X |
Mediastinum, Leukemia Mononuclear | X |
Parenchyma, Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Fibrosarcoma | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | |
Adenoma | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6| | |
| 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 7 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 29 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 50 |
Glandular, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 3 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + | 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6| | |
| 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M | 40 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 50 |
Pars Distalis, Adenoma | X X X X X X | 32 |
Pars Distalis, Adenoma, Multiple | X X X X X | 5 |
Pars Distalis, Leukemia Mononuclear | X X | 4 |
Pars Distalis, Pars Intermedia, Pars | | |
Nervosa, Leukemia Mononuclear | | 1 |
Pars Intermedia, Leukemia Mononuclear| | 1 |
Pars Nervosa, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 50 |
C-Cell, Adenoma | X | 6 |
C-Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 14 |
Adenoma | | 4 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 50 |
Granulosa Cell Tumor Benign | X | 1 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 50 |
Leiomyoma | | 1 |
Leukemia Mononuclear | | 1 |
Polyp Stromal | X X X | 7 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + M + | 48 |
Mediastinal, Leukemia Mononuclear | X | 2 |
Pancreatic, Leukemia Mononuclear | X | 5 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + | 46 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6| | |
| 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 50 |
Hemangioma | | 1 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Thymus | + + | 8 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 36 |
Adenocarcinoma | | 1 |
Fibroadenoma | X X X X X | 21 |
Fibroadenoma, Multiple | X X X | 8 |
__________________________________________________________________________|____________|
Skin | + + | 11 |
Subcutaneous Tissue, Carcinosarcoma, | | |
Poorly Differentiated | | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 5 |
Carcinosarcoma, Metastatic, Skin | | 1 |
Leukemia Mononuclear | X X | 9 |
Mediastinum, Leukemia Mononuclear | | 1 |
Parenchyma, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Nose | + + | 7 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Fibrosarcoma | X | 1 |
__________________________________________________________________________|____________|
Eye | + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6| | |
| 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
Adenoma | X | 1 |
Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|
| 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
Leiomyoma | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | M + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + + + + M + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
Leukemia Mononuclear | |
Pheochromocytoma Malignant | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + M + + + M + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X X X X X X |
Pars Distalis, Adenoma, Multiple | |
Pars Distalis, Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|
| 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + |
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Polyp Stromal | X X X |
Polyp Stromal, Multiple | X |
Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | M + + + + + M + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + |
Subcutaneous Tissue, Fibroma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|
| 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Leukemia Mononuclear | X |
Medulla, Carcinoma, Metastatic, | |
Pituitary Gland | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant, | |
Metastatic | |
Sarcoma, Metastatic, Lung | |
Pleura, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + I I I + |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|
DAY ON TEST | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|
| 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0.1% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + |
Leiomyoma | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + M + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + + + + + + M + + M + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
Leukemia Mononuclear | |
Pheochromocytoma Malignant | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M M + + M + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X |
Pars Distalis, Adenoma, Multiple | X |
Pars Distalis, Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|
DAY ON TEST | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|
| 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0.1% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + |
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + |
Polyp Stromal | X X X |
Polyp Stromal, Multiple | |
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thymus | + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + |
Fibroadenoma | X X X X X X X X X |
Fibroadenoma, Multiple | X X |
__________________________________________________________________________|
Skin | + + + + |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|
DAY ON TEST | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|
| 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0.1% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Leukemia Mononuclear | X |
Medulla, Carcinoma, Metastatic, | |
Pituitary Gland | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | |
Pheochromocytoma Malignant, | |
Metastatic | X |
Sarcoma, Metastatic, Lung | |
Pleura, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
__________________________________________________________________________|
Nose | + + + |
__________________________________________________________________________|
Trachea | + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + I |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4| | |
DAY ON TEST | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6| | |
| 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 12 |
__________________________________________________________________________|____________|
Intestine Large | + A | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A | 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A A + + + | 48 |
Leiomyoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A A + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A A + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 10 |
Neoplastic Nodule | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + | 49 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Tongue | + + + + + M + + + + + + + | 43 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 13 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + | 13 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + | 13 |
Leukemia Mononuclear | X X | 2 |
Pheochromocytoma Malignant | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A | 15 |
Adenoma | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4| | |
DAY ON TEST | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6| | |
| 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + M M + + | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + | 49 |
Pars Distalis, Adenoma | X X X X X X | 27 |
Pars Distalis, Adenoma, Multiple | X X X | 4 |
Pars Distalis, Carcinoma | | 1 |
Pars Distalis, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 43 |
C-Cell, Adenoma | | 3 |
C-Cell, Carcinoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + | 20 |
Adenoma | X X | 4 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + M + | 17 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + | 50 |
Polyp Stromal | X X | 8 |
Polyp Stromal, Multiple | | 1 |
Sarcoma Stromal | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + A | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 25 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | X | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 19 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 14 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + | 23 |
Leukemia Mononuclear | X X X | 8 |
__________________________________________________________________________|____________|
Thymus | + M | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4| | |
DAY ON TEST | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6| | |
| 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 36 |
Fibroadenoma | X X X | 17 |
Fibroadenoma, Multiple | X X X X X | 10 |
__________________________________________________________________________|____________|
Skin | + + | 15 |
Subcutaneous Tissue, Fibroma | | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 13 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 15 |
Leukemia Mononuclear | | 2 |
Medulla, Carcinoma, Metastatic, | | |
Pituitary Gland | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 20 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X X X | 4 |
Pheochromocytoma Malignant, | | |
Metastatic | | 1 |
Sarcoma, Metastatic, Lung | X | 1 |
Pleura, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Nose | + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | I + + I | 8 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Squamous Cell Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4| | |
DAY ON TEST | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6| | |
| 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + | 49 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|
| 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + |
Submandibular Gland, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | + + + M + + + + + + + + M + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Fibrosarcoma, Metastatic, Skin | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
Adenoma | |
Fibrosarcoma, Metastatic, Skin | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + + + + + + M M + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X |
Pars Distalis, Adenoma, Multiple | X X X X X |
Pars Distalis, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|
| 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + |
Adenoma | X |
Carcinoma | |
Sarcoma | |
__________________________________________________________________________|
Ovary | + M M + M M M M M + M M M M M + M + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + |
Adenocarcinoma | |
Polyp Stromal | X X X X X X X X X |
Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Lumbar, Fibrosarcoma, Metastatic, | |
Skin | |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + |
Adenocarcinoma | X X |
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|
| 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|
DAY ON TEST | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|
| 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% MF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + |
Submandibular Gland, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + M + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
Fibrosarcoma, Metastatic, Skin | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + M + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
Adenoma | |
Fibrosarcoma, Metastatic, Skin | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
Leukemia Mononuclear | |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M + M + M + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Adenoma, Multiple | X X X |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|
DAY ON TEST | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|
| 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% MF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + |
Adenoma | X X |
Carcinoma | X |
Sarcoma | |
__________________________________________________________________________|
Ovary | + M M M M M M M M + M M M M + + M M + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Adenocarcinoma | X |
Polyp Stromal | X X X X |
Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + |
Lumbar, Fibrosarcoma, Metastatic, | |
Skin | |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Thymus | + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
Adenocarcinoma | X |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|
DAY ON TEST | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|
| 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% MF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + |
__________________________________________________________________________|
Trachea | + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4| | |
DAY ON TEST | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4| | |
| 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X X | 13 |
__________________________________________________________________________|____________|
Mesentery | + M | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 7 |
Submandibular Gland, Leukemia | | |
Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Tongue | + + + M M + + + + M + + + | 43 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 7 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 13 |
Adenoma | X | 1 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 12 |
Leukemia Mononuclear | X | 3 |
Pheochromocytoma Benign | | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 8 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M + M + M + + + M | 36 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4| | |
DAY ON TEST | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4| | |
| 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + | 50 |
Pars Distalis, Adenoma | X X X X X X X X X | 26 |
Pars Distalis, Adenoma, Multiple | X | 9 |
Pars Distalis, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + | 47 |
C-Cell, Adenoma | X | 4 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M | 14 |
Adenoma | | 3 |
Carcinoma | X | 2 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | M M M + M + + M M M + M + | 15 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + | 50 |
Adenocarcinoma | | 1 |
Polyp Stromal | X X X | 16 |
Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 7 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 17 |
Lumbar, Fibrosarcoma, Metastatic, | | |
Skin | X | 1 |
Mediastinal, Leukemia Mononuclear | X | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + | 10 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 12 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 20 |
Leukemia Mononuclear | X X X | 8 |
__________________________________________________________________________|____________|
Thymus | + + + + | 7 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4| | |
DAY ON TEST | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4| | |
| 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + | 24 |
Adenocarcinoma | | 3 |
Fibroadenoma | X X X | 14 |
Fibroadenoma, Multiple | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + | 8 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 7 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 8 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 20 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Nose | + + + + | 7 |
__________________________________________________________________________|____________|
Trachea | + + + + | 7 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + I + | 6 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|
| 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + M + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + |
Polyp Adenomatous | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Adenoma | |
Leukemia Monocytic | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + |
Submandibular Gland, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|
| 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X |
Pars Distalis, Adenoma, Multiple | |
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Mononuclear | |
Pars Intermedia, Leukemia Mononuclear| |
Pars Nervosa, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + |
Adenoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + M + |
Granulosa-Theca Tumor Malignant | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Polyp Stromal | X |
Polyp Stromal, Multiple | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + M |
Mediastinal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + M + + + + + + + M |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + M |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|
| 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenocarcinoma | X |
Fibroadenoma | X X |
Fibroadenoma, Multiple | X X X |
__________________________________________________________________________|
Skin | + + + |
Subcutaneous Tissue, Sarcoma, Poorly | |
Differentiated | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Sarcoma | |
Intercostal, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Carcinoma, Extension, Metastatic, | |
Pituitary Gland | |
Leukemia Mononuclear | |
Choroid Plexus, Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Granulosa-Theca Tumor Malignant, | |
Metastatic, Ovary | |
Hepatocellular Carcinoma, Metastatic,| |
Uncertain Primary Site | X |
Leukemia Mononuclear | X X X |
Sarcoma, Metastatic, Poorly | |
Differentiated, Skin | |
__________________________________________________________________________|
Nose | + A + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|
| 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Leukemia Monocytic | |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|
| 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + |
Polyp Adenomatous | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Adenoma | |
Leukemia Monocytic | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
Submandibular Gland, Leukemia | |
Mononuclear | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + |
Adenoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|
| 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M M M M + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Adenoma, Multiple | X |
Pars Distalis, Carcinoma | X |
Pars Distalis, Leukemia Mononuclear | X |
Pars Intermedia, Leukemia Mononuclear| |
Pars Nervosa, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + |
Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + |
Granulosa-Theca Tumor Malignant | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Polyp Stromal | X X X X |
Polyp Stromal, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + M + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|
| 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenocarcinoma | |
Fibroadenoma | X X |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + + + + + |
Subcutaneous Tissue, Sarcoma, Poorly | |
Differentiated | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Sarcoma | X |
Intercostal, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
Carcinoma, Extension, Metastatic, | |
Pituitary Gland | X |
Leukemia Mononuclear | X X |
Choroid Plexus, Leukemia Mononuclear | X |
__________________________________________________________________________|
Spinal Cord | + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Granulosa-Theca Tumor Malignant, | |
Metastatic, Ovary | X |
Hepatocellular Carcinoma, Metastatic,| |
Uncertain Primary Site | |
Leukemia Mononuclear | X X X X |
Sarcoma, Metastatic, Poorly | |
Differentiated, Skin | X |
__________________________________________________________________________|
Nose | + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|
| 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + |
Leukemia Monocytic | |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4| | |
DAY ON TEST | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6| | |
| 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + | 47 |
Polyp Adenomatous | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 12 |
Neoplastic Nodule | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 50 |
Adenoma | X | 1 |
Leukemia Monocytic | X | 1 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 11 |
Submandibular Gland, Leukemia | | |
Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 39 |
Squamous Cell Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4| | |
DAY ON TEST | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6| | |
| 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 5 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + | 49 |
Pars Distalis, Adenoma | X X X X X X X X | 25 |
Pars Distalis, Adenoma, Multiple | X | 2 |
Pars Distalis, Carcinoma | | 1 |
Pars Distalis, Leukemia Mononuclear | X X | 3 |
Pars Intermedia, Leukemia Mononuclear| X | 1 |
Pars Nervosa, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 50 |
C-Cell, Adenoma | X | 2 |
C-Cell, Carcinoma | X | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 12 |
Adenoma | X | 4 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + M + | 48 |
Granulosa-Theca Tumor Malignant | | 1 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 50 |
Polyp Stromal | X X X X X | 10 |
Polyp Stromal, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 11 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 49 |
Mediastinal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4| | |
DAY ON TEST | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6| | |
| 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 9 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 12 |
__________________________________________________________________________|____________|
Thymus | M + + | 9 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 22 |
Adenocarcinoma | X | 2 |
Fibroadenoma | X X | 6 |
Fibroadenoma, Multiple | | 3 |
__________________________________________________________________________|____________|
Skin | + + | 11 |
Subcutaneous Tissue, Sarcoma, Poorly | | |
Differentiated | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 14 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Sarcoma | | 1 |
Intercostal, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 50 |
Carcinoma, Extension, Metastatic, | | |
Pituitary Gland | | 1 |
Leukemia Mononuclear | X | 3 |
Choroid Plexus, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 50 |
Granulosa-Theca Tumor Malignant, | | |
Metastatic, Ovary | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Uncertain Primary Site | | 1 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4| | |
DAY ON TEST | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6| | |
| 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Poorly | | |
Differentiated, Skin | | 1 |
__________________________________________________________________________|____________|
Nose | + + | 10 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + | 50 |
Leukemia Monocytic | X | 1 |
Leukemia Mononuclear | X X | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|
| 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + M + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + A +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + A +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X |
Lymphoma Malignant Lymphocytic | X |
Mesothelioma Malignant | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Mesentery | + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Lymphoma Malignant Lymphocytic | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + M |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + M + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tongue | + + M + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant Lymphocytic | X |
Schwannoma Benign | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|
| 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Lymphocytic | X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X |
Pheochromocytoma Benign, Multiple | X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + M +|
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + A M + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X|
Pars Distalis, Leukemia Mononuclear | X X X |
Pars Distalis, Lymphoma Malignant | |
Lymphocytic | X |
Pars Intermedia, Lymphoma Malignant | |
Lymphocytic | X |
Pars Nervosa, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Preputial Gland | + M + + + |
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + M + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|
| 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Lumbar, Leukemia Mononuclear | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Leukemia Mononuclear | X X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
Pancreatic, Leukemia Mononuclear | X X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Leukemia Mononuclear | |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + M + M + M + |
Leukemia Mononuclear | X X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | + M + + M + + + M + M |
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
Mediastinum, Basosquamous Tumor NOS | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + M + +|
Fibroadenoma | X X|
__________________________________________________________________________|
Skin | + + + + + + + +|
Basal Cell Carcinoma | |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|
| 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + |
Osteoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Choroid Plexus, Lymphoma Malignant | |
Lymphocytic | |
Choroid Plexus, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X X |
Lymphoma Malignant Lymphocytic | X |
Osteosarcoma, Metastatic, Bone | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|
| 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Mononuclear | X X X X X X X X |
Lymphoma Malignant Lymphocytic | X |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|
DAY ON TEST | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|
| 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | X X |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Lymphocytic | X |
Mesothelioma Malignant | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tongue | + + + + + + + + M + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
Schwannoma Benign | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|
DAY ON TEST | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|
| 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | |
Pheochromocytoma Benign, Multiple | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M |
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Leukemia Mononuclear | X |
Pars Distalis, Lymphoma Malignant | |
Lymphocytic | X |
Pars Intermedia, Lymphoma Malignant | |
Lymphocytic | |
Pars Nervosa, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + |
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|
DAY ON TEST | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|
| 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + + + + + + + + |
Lumbar, Leukemia Mononuclear | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Leukemia Mononuclear | X X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Sarcoma, Metastatic, | |
Uncertain Primary Site | X |
Pancreatic, Leukemia Mononuclear | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Leukemia Mononuclear | X X |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + |
Leukemia Mononuclear | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | + + |
Leukemia Mononuclear | |
Lymphoma Malignant Lymphocytic | X |
Mediastinum, Basosquamous Tumor NOS | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + |
Basal Cell Carcinoma | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|
DAY ON TEST | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|
| 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + |
Osteoma | X |
__________________________________________________________________________|
Skeletal Muscle | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Choroid Plexus, Lymphoma Malignant | |
Lymphocytic | |
Choroid Plexus, Sarcoma, Metastatic, | |
Uncertain Primary Site | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Lymphocytic | X |
Osteosarcoma, Metastatic, Bone | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|
DAY ON TEST | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|
| 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Lymphocytic | X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4| | |
DAY ON TEST | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6| | |
| 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 47 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 50 |
Hepatocellular Adenoma | | 3 |
Leukemia Mononuclear | X X X X | 16 |
Lymphoma Malignant Lymphocytic | X | 3 |
Mesothelioma Malignant | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 3 |
Lymphoma Malignant Lymphocytic | X | 3 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 16 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4| | |
DAY ON TEST | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6| | |
| 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X | 3 |
Schwannoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 7 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 5 |
Lymphoma Malignant Lymphocytic | X | 3 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X X X X | 8 |
Pheochromocytoma Benign, Multiple | X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M + + + + + + M M + + | 43 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + | 46 |
Pars Distalis, Adenoma | X X X | 14 |
Pars Distalis, Leukemia Mononuclear | X X | 6 |
Pars Distalis, Lymphoma Malignant | | |
Lymphocytic | X | 3 |
Pars Intermedia, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Pars Nervosa, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 50 |
C-Cell, Adenoma | X X X | 4 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Mesothelioma Malignant | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4| | |
DAY ON TEST | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6| | |
| 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 13 |
Adenoma | | 2 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 50 |
Mesothelioma Malignant | X | 4 |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X | 44 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 11 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 49 |
Lumbar, Leukemia Mononuclear | X | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Mediastinal, Leukemia Mononuclear | X X | 6 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Mediastinal, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Pancreatic, Leukemia Mononuclear | X X | 4 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Renal, Leukemia Mononuclear | X X | 4 |
Renal, Lymphoma Malignant Lymphocytic| X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 46 |
Leukemia Mononuclear | X X | 5 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + | 22 |
Leukemia Mononuclear | X | 4 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 15 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Thymus | + + + + + M | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4| | |
DAY ON TEST | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6| | |
| 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 2 |
Lymphoma Malignant Lymphocytic | X | 3 |
Mediastinum, Basosquamous Tumor NOS | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + | 13 |
Fibroadenoma | X X | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 20 |
Basal Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | X | 2 |
Subcutaneous Tissue, Fibroma | X | 2 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 10 |
Osteoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
Choroid Plexus, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Choroid Plexus, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X X | 14 |
Lymphoma Malignant Lymphocytic | X | 3 |
Osteosarcoma, Metastatic, Bone | X | 1 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4| | |
DAY ON TEST | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6| | |
| 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 44 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | I + + I | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 8 |
Lymphoma Malignant Lymphocytic | X | 3 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 16 |
Lymphoma Malignant Lymphocytic | X | 3 |
Mesothelioma Malignant | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|
DAY ON TEST | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|
| 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + M + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + M + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + M + + A |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Neoplastic Nodule | |
Neoplastic Nodule, Multiple | X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + |
Adenoma | X |
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + M + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|
DAY ON TEST | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|
| 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + M + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Adenoma, Multiple | X |
Pars Distalis, Leukemia Mononuclear | X X |
Pars Distalis, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Pars Intermedia, Leukemia Mononuclear| |
Pars Nervosa, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
Leukemia Mononuclear | X |
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Basosquamous Tumor Benign | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Adenoma | X X X X |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|
DAY ON TEST | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|
| 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Mesothelioma Benign | |
Mesothelioma Malignant | X X |
Interstitial Cell, Adenoma | X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
Leukemia Mononuclear | X |
Sternal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Lumbar, Leukemia Mononuclear | |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Leukemia Mononuclear | |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Pancreatic, Leukemia Mononuclear | X |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + |
Leukemia Mononuclear | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + M + M + |
Leukemia Mononuclear | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + |
Fibroadenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|
DAY ON TEST | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|
| 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Meningioma Benign | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Glands, Carcinoma | |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Serosa, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Mesothelioma Benign | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|
DAY ON TEST | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|
| 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|
DAY ON TEST | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|
| 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% LM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + A + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + A + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Neoplastic Nodule | X |
Neoplastic Nodule, Multiple | |
__________________________________________________________________________|
Mesentery | + + + |
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Adenoma | |
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + M + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + M |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|
DAY ON TEST | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|
| 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% LM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Pituitary Gland | + I + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Adenoma, Multiple | X X |
Pars Distalis, Leukemia Mononuclear | X X X X X |
Pars Distalis, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Pars Intermedia, Leukemia Mononuclear| X |
Pars Nervosa, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Basosquamous Tumor Benign | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + |
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + |
Adenoma | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|
DAY ON TEST | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|
| 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% LM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Mesothelioma Benign | |
Mesothelioma Malignant | |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + |
Leukemia Mononuclear | X |
Sternal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Lumbar, Leukemia Mononuclear | X |
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Leukemia Mononuclear | X X X X |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Pancreatic, Leukemia Mononuclear | X |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + + + + + + |
Leukemia Mononuclear | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M M |
Fibroadenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|
DAY ON TEST | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|
| 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% LM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Meningioma Benign | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Glands, Carcinoma | X |
__________________________________________________________________________|
Trachea | + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Serosa, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Mesothelioma Benign | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|
DAY ON TEST | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|
| 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% LM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6| | |
| 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 12 |
__________________________________________________________________________|____________|
Intestine Large | + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 12 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + | 44 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 50 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X X X X | 17 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Neoplastic Nodule | | 1 |
Neoplastic Nodule, Multiple | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Leukemia Mononuclear | | 2 |
Mesothelioma Malignant | X | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + | 50 |
Adenoma | X | 2 |
Leukemia Mononuclear | X X X | 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 14 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6| | |
| 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 18 |
Leukemia Mononuclear | X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 18 |
Leukemia Mononuclear | X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Pheochromocytoma Benign | X X X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 15 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + | 49 |
Pars Distalis, Adenoma | X | 14 |
Pars Distalis, Adenoma, Multiple | | 3 |
Pars Distalis, Leukemia Mononuclear | X X X X X | 12 |
Pars Distalis, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Pars Intermedia, Leukemia Mononuclear| | 1 |
Pars Nervosa, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 17 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | | 1 |
C-Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Basosquamous Tumor Benign | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + | 13 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6| | |
| 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 22 |
Adenoma | | 5 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + | 14 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 22 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + | 46 |
Leukemia Mononuclear | | 3 |
Mesothelioma Benign | X | 1 |
Mesothelioma Malignant | | 2 |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X | 43 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 12 |
Leukemia Mononuclear | X | 3 |
Sternal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 29 |
Lumbar, Leukemia Mononuclear | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Leukemia Mononuclear | X X | 6 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Pancreatic, Leukemia Mononuclear | X X X | 5 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Renal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 18 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 14 |
Leukemia Mononuclear | X X | 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 25 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6| | |
| 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X X X | 16 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | M + | 11 |
Leukemia Mononuclear | X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 10 |
Fibroadenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + | 18 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 12 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 15 |
Leukemia Mononuclear | X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Meningioma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 28 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X X X | 13 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X | 5 |
Glands, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Trachea | + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6| | |
| 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + I | 9 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 11 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
Serosa, Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X X | 18 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Mesothelioma Benign | X | 1 |
Mesothelioma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|
DAY ON TEST | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|
| 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M |
__________________________________________________________________________|
Intestine Large | + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + |
Leukemia Mononuclear | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + +|
Cholangiocarcinoma | |
Hemangiosarcoma | |
Hepatocellular Adenoma, Multiple | |
Leukemia Mononuclear | X X X X X X X X|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Neoplastic Nodule | X |
Neoplastic Nodule, Multiple | |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | |
Lymphoma Malignant Mixed | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + |
Sublingual Gland, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|
DAY ON TEST | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|
| 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant Mixed | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + |
Leukemia Mononuclear | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + |
Leukemia Mononuclear | |
Lymphoma Malignant Mixed | |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X |
Pheochromocytoma Benign, Multiple | |
__________________________________________________________________________|
Islets, Pancreatic | + + |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Adenoma, Multiple | |
Pars Distalis, Leukemia Mononuclear | X X X X|
Pars Distalis, Pars Intermedia, Pars | |
Nervosa, Leukemia Mononuclear | |
Pars Distalis, Pars Nervosa, | |
Leukemia Mononuclear | |
Pars Nervosa, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + |
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|
DAY ON TEST | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|
| 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Benign | |
Mesothelioma Malignant | X |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Mediastinal, Leukemia Mononuclear | X|
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + |
Hemangioma | X |
Hemangiosarcoma | |
Leukemia Mononuclear | X X X X X |
Lymphoma Malignant Mixed | |
Sarcoma | X |
__________________________________________________________________________|
Thymus | + + |
Leukemia Mononuclear | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
Fibroadenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + +|
Basosquamous Tumor Benign | |
Keratoacanthoma | |
Squamous Cell Papilloma | X|
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | |
Subcutaneous Tissue, Myxoma | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|
DAY ON TEST | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|
| 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
Leukemia Mononuclear | X |
Choroid Plexus, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Carcinoma, Metastatic, Thyroid Gland | |
Cholangiocarcinoma, Metastatic, Liver| |
Leukemia Mononuclear | X X X |
Lymphoma Malignant Mixed | |
Mediastinum, Schwannoma Malignant, | |
Metastatic, Heart | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + I |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|
DAY ON TEST | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|
| 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma Benign | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|
| 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Intestine Large | + + A + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + A + + |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + |
Leukemia Mononuclear | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | M + + M + + M + + + A M + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Cholangiocarcinoma | X |
Hemangiosarcoma | X |
Hepatocellular Adenoma, Multiple | |
Leukemia Mononuclear | X X X X X X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Neoplastic Nodule | |
Neoplastic Nodule, Multiple | X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Mixed | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X X |
Leukemia Mononuclear | X X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + |
Sublingual Gland, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Tongue | + M + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|
| 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Mixed | |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Mixed | |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X |
Pheochromocytoma Benign, Multiple | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M + + + + + + + + + + + + I |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Adenoma, Multiple | X |
Pars Distalis, Leukemia Mononuclear | X X X X |
Pars Distalis, Pars Intermedia, Pars | |
Nervosa, Leukemia Mononuclear | |
Pars Distalis, Pars Nervosa, | |
Leukemia Mononuclear | |
Pars Nervosa, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|
| 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Benign | |
Mesothelioma Malignant | |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | |
Mediastinal, Leukemia Mononuclear | |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + |
Hemangioma | |
Hemangiosarcoma | X |
Leukemia Mononuclear | X X X X X X X X |
Lymphoma Malignant Mixed | |
Sarcoma | |
__________________________________________________________________________|
Thymus | + + + + + |
Leukemia Mononuclear | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
Fibroadenoma | X X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + |
Basosquamous Tumor Benign | |
Keratoacanthoma | X |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | |
Subcutaneous Tissue, Myxoma | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|
| 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Leukemia Mononuclear | X |
Choroid Plexus, Lymphoma Malignant | |
Mixed | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Carcinoma, Metastatic, Thyroid Gland | |
Cholangiocarcinoma, Metastatic, Liver| X |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Mixed | |
Mediastinum, Schwannoma Malignant, | |
Metastatic, Heart | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | I I |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|
| 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma Benign | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1| | |
DAY ON TEST | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9| | |
| 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 13 |
Leukemia Mononuclear | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + M + + | 48 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M + M + + + + + + + + + + + + + | 43 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 50 |
Cholangiocarcinoma | | 1 |
Hemangiosarcoma | | 1 |
Hepatocellular Adenoma, Multiple | X | 1 |
Leukemia Mononuclear | X X X X X X | 22 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Neoplastic Nodule | X | 2 |
Neoplastic Nodule, Multiple | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Leukemia Mononuclear | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + | 50 |
Adenoma | | 2 |
Leukemia Mononuclear | X X | 9 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 12 |
Sublingual Gland, Lymphoma Malignant | | |
Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 83
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1| | |
DAY ON TEST | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9| | |
| 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + M + M + + + + | 47 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 18 |
Leukemia Mononuclear | X X | 4 |
Lymphoma Malignant Mixed | X | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 21 |
Leukemia Mononuclear | X | 5 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 21 |
Leukemia Mononuclear | X | 5 |
Lymphoma Malignant Mixed | X | 1 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X X | 9 |
Pheochromocytoma Benign, Multiple | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 13 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + I + + + + M + + + + + + + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + | 50 |
Pars Distalis, Adenoma | X X X X X X X X | 18 |
Pars Distalis, Adenoma, Multiple | | 1 |
Pars Distalis, Leukemia Mononuclear | X X | 10 |
Pars Distalis, Pars Intermedia, Pars | | |
Nervosa, Leukemia Mononuclear | X | 1 |
Pars Distalis, Pars Nervosa, | | |
Leukemia Mononuclear | X | 1 |
Pars Nervosa, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 22 |
C-Cell, Adenoma | X | 4 |
C-Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 84
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1| | |
DAY ON TEST | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9| | |
| 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 13 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 19 |
Adenoma | X X | 3 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + | 12 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 23 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
Mesothelioma Benign | X | 1 |
Mesothelioma Malignant | X | 2 |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X | 45 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 12 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 26 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X | 4 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
Pancreatic, Leukemia Mononuclear | X X | 5 |
Renal, Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 15 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 17 |
Leukemia Mononuclear | X X X | 5 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 38 |
Hemangioma | | 1 |
Hemangiosarcoma | | 1 |
Leukemia Mononuclear | X X X X X | 18 |
Lymphoma Malignant Mixed | X | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + | 13 |
Leukemia Mononuclear | X X | 3 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 85
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1| | |
DAY ON TEST | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9| | |
| 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + M M | 14 |
Fibroadenoma | X X | 5 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Skin | + M + + + + + + M | 19 |
Basosquamous Tumor Benign | X | 1 |
Keratoacanthoma | | 1 |
Squamous Cell Papilloma | X | 3 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | X | 1 |
Subcutaneous Tissue, Myxoma | X | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | M + M + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 12 |
Leukemia Mononuclear | X X | 4 |
Choroid Plexus, Lymphoma Malignant | | |
Mixed | X | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 31 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Leukemia Mononuclear | X X X X X | 12 |
Lymphoma Malignant Mixed | X | 1 |
Mediastinum, Schwannoma Malignant, | | |
Metastatic, Heart | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 86
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1| | |
DAY ON TEST | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9| | |
| 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + + I I + | 6 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 9 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + M + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X X X | 22 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Mesothelioma Benign | X | 1 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 87
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 1| 7| 7| 6| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 6| 4| 3| 1|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 2| 7| 8| 8| 2| 2| 2| 8| 6| 2| 2| 2| 2| 6| 0| 2| 6| 2| 8|
| 7| 5| 0| 0| 9| 7| 9| 3| 9| 9| 9| 7| 7| 6| 5| 8| 8| 8| 9| 3| 4| 6| 3| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + A + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + M + A + + + + + + M + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + A + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + A + A + + + + + + A + + + + + + + |
__________________________________________________________________________|
Intestine Small | + A + A + + + + + + A + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + A + + + + + + A + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + A + A + + + + + + A + + + + + + A |
Adenoma | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + A + + + + + + A + + + + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Sarcoma, Poorly Differentiated | |
__________________________________________________________________________|
Pancreas | + M + + + + + + + + A + + + + + + A |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + M + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | M M + + + + + + + M + + + + + + + M |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X |
Pheochromocytoma Benign, Multiple | X |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + M + + + A |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + I + + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + A + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X |
Pars Distalis, Adenoma, Multiple | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 1| 7| 7| 6| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 6| 4| 3| 1|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 2| 7| 8| 8| 2| 2| 2| 8| 6| 2| 2| 2| 2| 6| 0| 2| 6| 2| 8|
| 7| 5| 0| 0| 9| 7| 9| 3| 9| 9| 9| 7| 7| 6| 5| 8| 8| 8| 9| 3| 4| 6| 3| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | |
Follicular Cell, Adenocarcinoma | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + M + + + M + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + M + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + |
Mesothelioma Malignant | X |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | M M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + M |
Fibroadenoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 1| 7| 7| 6| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 6| 4| 3| 1|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 2| 7| 8| 8| 2| 2| 2| 8| 6| 2| 2| 2| 2| 6| 0| 2| 6| 2| 8|
| 7| 5| 0| 0| 9| 7| 9| 3| 9| 9| 9| 7| 7| 6| 5| 8| 8| 8| 9| 3| 4| 6| 3| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Proximal Convoluted Renal Tubule, | |
Adenoma | |
Renal Tubule, Adenocarcinoma | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + M |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 6| 1| 4| 1| 6| 5| 4| 4| 1| 7| 7| 6| 4| 4| 6| 6| 1| 5| 4|
DAY ON TEST | 2| 2| 2| 9| 7| 6| 1| 8| 6| 9| 9| 8| 6| 6| 9| 2| 2| 9| 6| 6| 7| 7| 9| 5| 6|
| 8| 9| 4| 7| 6| 7| 7| 9| 5| 1| 4| 1| 5| 3| 1| 3| 7| 3| 3| 3| 6| 4| 1| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4.0% HM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + + |
Sarcoma, Poorly Differentiated | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | + + + + + + + + + + M + + + + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + M + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + M + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X |
Pheochromocytoma Benign, Multiple | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + |
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Adenoma, Multiple | |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 6| 1| 4| 1| 6| 5| 4| 4| 1| 7| 7| 6| 4| 4| 6| 6| 1| 5| 4|
DAY ON TEST | 2| 2| 2| 9| 7| 6| 1| 8| 6| 9| 9| 8| 6| 6| 9| 2| 2| 9| 6| 6| 7| 7| 9| 5| 6|
| 8| 9| 4| 7| 6| 7| 7| 9| 5| 1| 4| 1| 5| 3| 1| 3| 7| 3| 3| 3| 6| 4| 1| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4.0% HM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X |
Follicular Cell, Adenocarcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Adenoma | |
Carcinoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + |
Mesothelioma Malignant | |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 6| 1| 4| 1| 6| 5| 4| 4| 1| 7| 7| 6| 4| 4| 6| 6| 1| 5| 4|
DAY ON TEST | 2| 2| 2| 9| 7| 6| 1| 8| 6| 9| 9| 8| 6| 6| 9| 2| 2| 9| 6| 6| 7| 7| 9| 5| 6|
| 8| 9| 4| 7| 6| 7| 7| 9| 5| 1| 4| 1| 5| 3| 1| 3| 7| 3| 3| 3| 6| 4| 1| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4.0% HM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Proximal Convoluted Renal Tubule, | |
Adenoma | |
Renal Tubule, Adenocarcinoma | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 1| 6| 4| | |
DAY ON TEST | 2| 2| 2| 6| 7| 2| 2| 1| 1| 9| 2| 2| 2| 2| 2| 2| 9| 9| 9| 6| | |
| 8| 2| 4| 2| 4| 4| 3| 5| 3| 8| 8| 8| 9| 9| 4| 8| 1| 1| 2| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + I + + + + + I | 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + | 45 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + M + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 50 |
Hepatocellular Carcinoma | | 1 |
Leukemia Mononuclear | X X X | 13 |
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Sarcoma, Poorly Differentiated | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 47 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + I + + + + + + + | 48 |
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + M + + + | 44 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
Pheochromocytoma Malignant | X X | 2 |
Pheochromocytoma Benign | X X X X | 9 |
Pheochromocytoma Benign, Multiple | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 41 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 94
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 1| 6| 4| | |
DAY ON TEST | 2| 2| 2| 6| 7| 2| 2| 1| 1| 9| 2| 2| 2| 2| 2| 2| 9| 9| 9| 6| | |
| 8| 2| 4| 2| 4| 4| 3| 5| 3| 8| 8| 8| 9| 9| 4| 8| 1| 1| 2| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | X | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + I + I + + + + + M + + + + + + + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 48 |
Pars Distalis, Adenoma | X X | 11 |
Pars Distalis, Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 49 |
C-Cell, Adenoma | | 1 |
Follicular Cell, Adenocarcinoma | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + | 49 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 15 |
Adenoma | X | 1 |
Carcinoma | | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + | 50 |
Mesothelioma Malignant | | 1 |
Interstitial Cell, Adenoma | X X X X X X X X X X X X X X X X | 45 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 9 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + | 50 |
Mediastinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 19 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Thymus | M + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 9 |
Fibroadenoma | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 95
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 1| 6| 4| | |
DAY ON TEST | 2| 2| 2| 6| 7| 2| 2| 1| 1| 9| 2| 2| 2| 2| 2| 2| 9| 9| 9| 6| | |
| 8| 2| 4| 2| 4| 4| 3| 5| 3| 8| 8| 8| 9| 9| 4| 8| 1| 1| 2| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + | 18 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | X | 3 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 23 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X | 7 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | X | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 49 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
Proximal Convoluted Renal Tubule, | | |
Adenoma | X | 1 |
Renal Tubule, Adenocarcinoma | | 1 |
Renal Tubule, Adenoma | | 2 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 96
NTP Experiment-Test: 05033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC QUERCETIN Date: 04/09/97
Route: DOSED FEED Time: 10:08:26
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 1| 6| 4| | |
DAY ON TEST | 2| 2| 2| 6| 7| 2| 2| 1| 1| 9| 2| 2| 2| 2| 2| 2| 9| 9| 9| 6| | |
| 8| 2| 4| 2| 4| 4| 3| 5| 3| 8| 8| 8| 9| 9| 4| 8| 1| 1| 2| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X X | 13 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 97
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