TDMS Study 05033-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
QUERCETIN
NTP Experiment-Test: 05033-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/04/94
Route: DOSED FEED Time: 20:31:55
Facility: TSI Mason Research
Chemical CAS #: 117-39-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70
Scheduled Sacrifice 20 20 20 20
Early Deaths
Moribund 19 18 13 19
Dead 1 4 2 3
Survivors
Terminal Sacrifice 29 28 35 27
Moribund 1
Dead 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (11) (8) (48)
Intestine Large, Colon (50) (11) (7) (48)
Intestine Large, Rectum (48) (11) (7) (47)
Polyp Adenomatous 1 (2%)
Intestine Small, Duodenum (50) (48) (50) (49)
Leiomyoma 1 (2%)
Intestine Small, Ileum (49) (48) (49) (49)
Intestine Small, Jejunum (50) (47) (49) (49)
Liver (50) (50) (50) (50)
Neoplastic Nodule 1 (2%) 1 (2%)
Mesentery (2) (6) (2) (1)
Pancreas (50) (49) (50) (50)
Adenoma 1 (2%)
Salivary Glands (7) (12) (7) (11)
Stomach, Forestomach (49) (50) (50) (47)
Stomach, Glandular (50) (49) (50) (50)
Tongue (29) (43) (43) (39)
Squamous Cell Carcinoma 2 (5%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (13) (7) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (8%)
Fibrosarcoma, Metastatic, Skin 1 (14%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (14) (13) (50)
Adrenal Gland, Cortex (50) (13) (13) (50)
Adenoma 1 (8%) 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (8%)
Adrenal Gland, Medulla (49) (13) (12) (50)
Pheochromocytoma Malignant 1 (2%) 1 (8%)
Pheochromocytoma Benign 3 (6%) 3 (25%) 1 (2%)
Islets, Pancreatic (44) (15) (8) (49)
Adenoma 2 (5%) 3 (20%) 1 (13%)
Parathyroid Gland (40) (39) (36) (43)
Adenoma 1 (3%)
Pituitary Gland (50) (49) (50) (49)
Pars Distalis, Adenoma 32 (64%) 27 (55%) 26 (52%) 25 (51%)
Pars Distalis, Adenoma, Multiple 5 (10%) 4 (8%) 9 (18%) 2 (4%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Pars Distalis, Pars Intermedia, Pars Nervosa,
Leukemia Mononuclear 1 (2%)
Thyroid Gland (50) (43) (47) (50)
C-Cell, Adenoma 6 (12%) 3 (7%) 4 (9%) 2 (4%)
C-Cell, Carcinoma 2 (4%) 3 (7%) 2 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (14) (20) (14) (12)
Adenoma 4 (29%) 4 (20%) 3 (21%) 4 (33%)
Carcinoma 1 (7%) 1 (5%) 2 (14%)
Sarcoma 1 (7%)
Ovary (50) (17) (15) (48)
Granulosa Cell Tumor Benign 1 (2%)
Granulosa-Theca Tumor Malignant 1 (2%)
Uterus (50) (50) (50) (50)
Adenocarcinoma 1 (2%)
Leiomyoma 1 (2%)
Polyp Stromal 7 (14%) 8 (16%) 16 (32%) 10 (20%)
Polyp Stromal, Multiple 1 (2%) 1 (2%)
Sarcoma Stromal 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (8) (11) (7) (11)
Lymph Node (48) (25) (17) (49)
Lumbar, Fibrosarcoma, Metastatic, Skin 1 (6%)
Lymph Node, Mandibular (46) (19) (10) (46)
Lymph Node, Mesenteric (9) (14) (12) (9)
Spleen (50) (23) (20) (50)
Hemangioma 1 (2%)
Thymus (8) (10) (7) (9)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (36) (36) (24) (22)
Adenocarcinoma 1 (3%) 3 (13%) 2 (9%)
Fibroadenoma 21 (58%) 17 (47%) 14 (58%) 6 (27%)
Fibroadenoma, Multiple 8 (22%) 10 (28%) 2 (8%) 3 (14%)
Skin (11) (15) (8) (11)
Subcutaneous Tissue, Carcinosarcoma, Poorly
Differentiated 1 (9%)
Subcutaneous Tissue, Fibroma 2 (18%) 3 (20%) 1 (13%)
Subcutaneous Tissue, Fibrosarcoma 1 (13%)
Subcutaneous Tissue, Sarcoma, Poorly
Differentiated 1 (9%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (3)
Sarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (15) (8) (50)
Carcinoma, Extension, Metastatic, Pituitary
Gland 1 (2%)
Medulla, Carcinoma, Metastatic, Pituitary
Gland 1 (7%)
Spinal Cord (1) (2) (2)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (20) (20) (50)
Alveolar/Bronchiolar Adenoma 5 (10%) 1 (5%)
Alveolar/Bronchiolar Carcinoma 1 (5%)
Carcinosarcoma, Metastatic, Skin 1 (2%)
Granulosa-Theca Tumor Malignant, Metastatic,
Ovary 1 (2%)
Hepatocellular Carcinoma, Metastatic,
Uncertain Primary Site 1 (2%)
Pheochromocytoma Malignant, Metastatic 1 (5%)
Sarcoma, Metastatic, Lung 1 (5%)
Sarcoma, Metastatic, Poorly Differentiated,
Skin 1 (2%)
Pleura, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (5%)
Nose (7) (12) (7) (10)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2) (1)
Fibrosarcoma 1 (100%)
Zymbal's Gland (2) (2)
Adenoma 1 (50%)
Squamous Cell Carcinoma 1 (50%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (50) (50)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (49) (50) (50)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Monocytic 1 (2%)
Leukemia Mononuclear 9 (18%) 10 (20%) 13 (26%) 12 (24%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.1% LF 1.0% MF 4.0% HF
UF
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 48 43 44
Total Primary Neoplasms 118 103 106 81
Total Animals with Benign Neoplasms 49 44 42 35
Total Benign Neoplasms 101 82 82 59
Total Animals with Malignant Neoplasms 15 19 19 19
Total Malignant Neoplasms 17 21 24 22
Total Animals with Metastatic Neoplasms 1 4 1 4
Total Metastatic Neoplasm 1 6 3 4
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70
Scheduled Sacrifice 20 20 20 20
Early Deaths
Moribund 21 15 22 21
Dead 3 7 3 6
Survivors
Moribund 1 1
Terminal Sacrifice 25 27 22 19
Dead 1 1 2 3
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (11) (13) (46)
Intestine Large, Colon (49) (12) (11) (47)
Intestine Small, Duodenum (48) (47) (48) (46)
Intestine Small, Ileum (47) (47) (48) (45)
Adenoma 1 (2%)
Intestine Small, Jejunum (48) (44) (43) (44)
Liver (50) (50) (50) (50)
Cholangiocarcinoma 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Adenoma 3 (6%) 1 (2%)
Hepatocellular Adenoma, Multiple 1 (2%)
Neoplastic Nodule 1 (2%) 2 (4%)
Neoplastic Nodule, Multiple 1 (2%) 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mesentery (7) (6) (5) (5)
Sarcoma, Poorly Differentiated 1 (20%)
Pancreas (50) (50) (50) (47)
Adenoma 2 (4%) 2 (4%)
Salivary Glands (16) (14) (12) (10)
Stomach, Forestomach (49) (49) (49) (46)
Stomach, Glandular (50) (50) (49) (48)
Tongue (45) (48) (47) (44)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (18) (18) (50)
Schwannoma Benign 1 (2%)
Schwannoma Malignant 1 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (18) (21) (49)
Adrenal Gland, Medulla (50) (18) (21) (49)
Pheochromocytoma Malignant 1 (2%) 1 (5%) 2 (4%)
Pheochromocytoma Benign 8 (16%) 4 (22%) 9 (43%) 9 (18%)
Pheochromocytoma Benign, Multiple 4 (8%) 1 (5%) 2 (4%)
Islets, Pancreatic (47) (15) (13) (41)
Adenoma 2 (13%) 3 (7%)
Carcinoma 1 (8%)
Parathyroid Gland (43) (45) (43) (43)
Adenoma 1 (2%)
Pituitary Gland (46) (49) (50) (48)
Pars Distalis, Adenoma 14 (30%) 14 (29%) 18 (36%) 11 (23%)
Pars Distalis, Adenoma, Multiple 3 (6%) 1 (2%) 1 (2%)
Pars Distalis, Pars Intermedia, Pars Nervosa,
Leukemia Mononuclear 1 (2%)
Thyroid Gland (50) (17) (22) (49)
C-Cell, Adenoma 4 (8%) 1 (6%) 4 (18%) 1 (2%)
C-Cell, Carcinoma 1 (2%) 2 (12%) 1 (5%)
Follicular Cell, Adenocarcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Basosquamous Tumor Benign 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (13) (13) (49)
Preputial Gland (13) (22) (19) (15)
Adenoma 2 (15%) 5 (23%) 3 (16%) 1 (7%)
Carcinoma 1 (8%) 1 (5%) 3 (20%)
Squamous Cell Carcinoma 1 (5%)
Prostate (49) (14) (12) (48)
Seminal Vesicle (50) (22) (23) (49)
Testes (50) (46) (48) (50)
Interstitial Cell, Adenoma 44 (88%) 43 (93%) 45 (94%) 45 (90%)
Page 8
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (11) (12) (12) (9)
Lymph Node (49) (29) (26) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (4%)
Mediastinal, Sarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Lymph Node, Mandibular (46) (18) (15) (47)
Carcinoma, Metastatic, Thyroid Gland 1 (6%)
Lymph Node, Mesenteric (22) (14) (17) (19)
Spleen (50) (25) (38) (50)
Hemangioma 1 (3%)
Hemangiosarcoma 1 (3%)
Sarcoma 1 (3%)
Thymus (14) (11) (13) (5)
Mediastinum, Basosquamous Tumor NOS 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (13) (10) (14) (9)
Fibroadenoma 5 (38%) 1 (10%) 5 (36%) 3 (33%)
Skin (20) (18) (19) (18)
Basal Cell Carcinoma 1 (5%)
Basosquamous Tumor Benign 1 (5%)
Keratoacanthoma 1 (5%)
Squamous Cell Papilloma 2 (10%) 3 (16%) 1 (6%)
Subcutaneous Tissue, Fibroma 2 (10%) 1 (6%) 1 (5%) 3 (17%)
Subcutaneous Tissue, Fibrosarcoma 1 (5%)
Subcutaneous Tissue, Lipoma 1 (5%)
Subcutaneous Tissue, Myxoma 1 (5%)
Subcutaneous Tissue, Sarcoma 1 (6%) 1 (5%) 1 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (10) (12) (15) (23)
Osteoma 1 (10%)
Skeletal Muscle (1) (2)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (15) (12) (50)
Meningioma Benign 1 (7%)
Choroid Plexus, Sarcoma, Metastatic,
Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (28) (31) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (3%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (3%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (4%) 1 (3%)
Cholangiocarcinoma, Metastatic, Liver 1 (3%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%) 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Mediastinum, Schwannoma Malignant,
Metastatic, Heart 1 (3%)
Nose (44) (48) (49) (49)
Squamous Cell Papilloma 1 (2%)
Glands, Carcinoma 1 (2%)
Trachea (50) (12) (12) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (9) (6) (3)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Proximal Convoluted Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Adenocarcinoma 1 (2%)
Renal Tubule, Adenoma 2 (4%)
Urinary Bladder (50) (49) (49) (48)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 16 (32%) 18 (36%) 22 (44%) 13 (26%)
Lymphoma Malignant Histiocytic 1 (2%)
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50) *(50)
Lymphoma Malignant Lymphocytic 3 (6%)
Lymphoma Malignant Mixed 1 (2%) 1 (2%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
Mesothelioma Benign 1 (2%) 1 (2%)
Mesothelioma Malignant 4 (8%) 3 (6%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05033-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC QUERCETIN Date: 09/04/94
Route: DOSED FEED Time: 20:31:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.1% LM 1.0% MM 4.0% HM
UM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50 48
Total Primary Neoplasms 125 111 139 113
Total Animals with Benign Neoplasms 49 48 50 48
Total Benign Neoplasms 95 82 102 88
Total Animals with Malignant Neoplasms 27 27 32 21
Total Malignant Neoplasms 29 29 37 25
Total Animals with Metastatic Neoplasms 4 1 3 1
Total Metastatic Neoplasm 8 2 4 1
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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