TDMS Study 05033-01 Pathology Tables
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
Facility: TSI Mason Research
Chemical CAS #: 117-39-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|
| 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | 1 X 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + M + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Basophilic Focus | 1 2 1 2 2 1 1 2 1 1 1 1 2 1 1 1 1 |
Clear Cell Focus | |
Developmental Malformation | 2 2 |
Eosinophilic Focus | 2 |
Fatty Change | 2 3 4 3 2 |
Inflammation, Chronic, Granulomatous | 1 1 2 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | 3 |
Necrosis, Coagulative | 1 |
Pigmentation | 1 |
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic, Granulomatous | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Atrophy | 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Edema | |
Erosion | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | 1 |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|
| 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 4 |
Mucosa, Dilatation | 1 |
Muscularis, Developmental | |
Malformation | 2 |
Muscularis, Mineralization | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 1 2 2 2 1 1 1 2 1 2 1 1 2 1 2 1 |
Coronary Artery, Inflammation, | |
Chronic Active, Necrotizing | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 2 1 2 1 1 1 1 1 2 1 1 |
Congestion | |
Degeneration, Fatty | |
Hyperplasia | 1 1 2 1 1 |
Necrosis, Coagulative | 3 |
Thrombosis | |
Vacuolization Cytoplasmic | 1 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 1 2 1 |
Hyperplasia | 1 |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + |
Ectopic Tissue | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + M M + M |
Cyst | |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 2 2 2 |
Pars Distalis, Cyst | 2 2 1 1 2 2 1 3 2 |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 1 2 1 1 1 |
Pars Distalis, Pigmentation | |
Pars Intermedia, Angiectasis | 2 |
Pars Nervosa, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|
| 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Cyst | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + |
Abscess | |
Cyst | 3 |
Hyperplasia | 2 |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + |
Cyst | 4 3 |
Periovarian Tissue, Cyst | 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Hydrometra | 1 2 1 |
Endometrium, Hyperplasia | 2 1 |
Lumen, Exudate | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Deep Cervical, Hyperplasia, Plasma | |
Cell | |
Mediastinal, Hemorrhage | 1 1 |
Mediastinal, Pigmentation | 1 |
Pancreatic, Hemorrhage | 3 |
Renal, Hemorrhage | 1 |
Renal, Infiltration Cellular | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M |
Ectasia | 2 1 2 2 |
Hemorrhage | 4 2 3 1 3 3 1 |
Hyperplasia, Plasma Cell | 2 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 2 |
Pigmentation | 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | 3 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|
| 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 2 |
Thrombosis | |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + M |
Depletion Lymphoid | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | |
Hyperplasia | 2 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Hydrocephalus | 2 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Crystals | 3 |
Hemorrhage | 2 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 3 1 1 1 |
Inflammation, Chronic | 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 4 |
Synechia | |
Retina, Degeneration | 4 3 |
Sclera, Mineralization | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + |
Nephropathy | 3 1 3 3 1 1 2 2 2 1 3 1 3 2 1 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 1| 7| 7| 1| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 1| 6| 9| 3| 2| 9| 1| 7| 3| 2| 3| 2| 4| 2| 8| 0| 6| 6| 2| 3| 8| 3| 6|
| 1| 4| 8| 4| 1| 2| 5| 1| 3| 2| 1| 9| 1| 4| 1| 3| 7| 6| 6| 6| 9| 2| 6| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Collecting Tubule, Mineralization | |
Renal Tubule, Hyperplasia | 1 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
Subserosa, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|
| 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
Parasite Metazoan | 2 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Angiectasis | |
Basophilic Focus | 2 2 2 1 2 1 1 2 1 1 2 1 1 |
Clear Cell Focus | 2 3 3 |
Developmental Malformation | X |
Eosinophilic Focus | |
Fatty Change | 4 1 3 1 |
Inflammation, Chronic, Granulomatous | 1 1 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mixed Cell Focus | 1 |
Necrosis, Coagulative | 1 |
Pigmentation | |
Bile Duct, Hyperplasia | 3 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic, Granulomatous | 3 |
Necrosis, Coagulative | 4 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Atrophy | 1 1 1 3 2 2 |
Inflammation, Chronic | 1 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + M |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + |
Acanthosis | 1 |
Edema | |
Erosion | 1 |
Hyperkeratosis | 1 |
Hyperplasia, Basal Cell | 1 1 |
Inflammation, Chronic Active | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|
| 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
Mucosa, Dilatation | 2 1 1 |
Muscularis, Developmental | |
Malformation | |
Muscularis, Mineralization | 2 |
__________________________________________________________________________|
Tongue | + + + M + + + + + + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 3 2 1 2 2 2 2 2 1 1 2 |
Coronary Artery, Inflammation, | |
Chronic Active, Necrotizing | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + |
Angiectasis | 1 2 2 3 2 1 1 |
Congestion | |
Degeneration, Fatty | 3 |
Hyperplasia | 1 1 1 1 2 2 |
Necrosis, Coagulative | |
Thrombosis | 3 |
Vacuolization Cytoplasmic | 1 1 2 3 2 1 1 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + |
Angiectasis | |
Hyperplasia | 1 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
Ectopic Tissue | X |
__________________________________________________________________________|
Parathyroid Gland | M M + + + M M + + + + + + + + I |
Cyst | 1 |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 2 3 2 2 1 |
Pars Distalis, Cyst | 3 2 1 2 1 3 1 2 2 2 1 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 1 1 2 2 2 |
Pars Distalis, Pigmentation | 1 |
Pars Intermedia, Angiectasis | 3 |
Pars Nervosa, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 4 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|
| 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Cyst | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + |
Abscess | |
Cyst | |
Hyperplasia | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + |
Cyst | |
Periovarian Tissue, Cyst | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Hydrometra | 3 1 1 1 |
Endometrium, Hyperplasia | 1 1 |
Lumen, Exudate | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + |
__________________________________________________________________________|
Lymph Node | + + + M + + + + + + + + + + + + |
Deep Cervical, Hyperplasia, Plasma | |
Cell | |
Mediastinal, Hemorrhage | 1 1 |
Mediastinal, Pigmentation | 1 |
Pancreatic, Hemorrhage | |
Renal, Hemorrhage | |
Renal, Infiltration Cellular | |
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + M + + + + + + + + |
Ectasia | 2 2 1 |
Hemorrhage | 2 3 1 3 1 2 1 1 1 3 |
Hyperplasia, Plasma Cell | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Depletion Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|
| 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | |
Thrombosis | |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + |
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + |
Hyperplasia, Cystic | |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Skin | + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
Hydrocephalus | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Crystals | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic | |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Synechia | 4 |
Retina, Degeneration | 4 |
Sclera, Mineralization | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Nephropathy | 2 3 2 2 3 3 1 2 3 1 2 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 4| 1| 7| 7| 6| 1| 4| 7| 6| 1| 4| 4| 7| 7| 6| 7| 1| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 3| 9| 6| 9| 3| 3| 7| 9| 6| 2| 2| 9| 6| 2| 3| 2| 6| 2| 9| 2| 3| 2| 2| 6|
| 8| 2| 1| 4| 1| 1| 2| 2| 1| 4| 4| 5| 3| 6| 2| 1| 9| 0| 4| 3| 9| 2| 5| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Collecting Tubule, Mineralization | 1 |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
Subserosa, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6| | |
| 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 50 |
Parasite Metazoan | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 50 |
Parasite Metazoan | 1 X | 9 1.1|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 48 |
Parasite Metazoan | 1 1 1 2 | 5 1.2|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | 1 2 1 1 1 1 1 1 2 1 | 40 1.3|
Clear Cell Focus | 1 | 4 2.3|
Developmental Malformation | | 3 2.0|
Eosinophilic Focus | 1 2 | 3 1.7|
Fatty Change | 2 3 3 1 1 | 14 2.4|
Inflammation, Chronic, Granulomatous | 1 1 1 1 1 | 12 1.1|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 | 2 1.0|
Mixed Cell Focus | 3 4 | 4 2.8|
Necrosis, Coagulative | 1 1 | 4 1.0|
Pigmentation | | 1 1.0|
Bile Duct, Hyperplasia | 1 1 1 | 17 1.2|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Inflammation, Chronic, Granulomatous | | 1 3.0|
Necrosis, Coagulative | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 50 |
Atrophy | 1 1 1 1 1 1 | 21 1.2|
Inflammation, Chronic | 1 1 1 1 1 | 17 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 7 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 49 |
Acanthosis | 2 2 | 3 1.7|
Edema | 2 | 1 2.0|
Erosion | | 1 1.0|
Hyperkeratosis | 2 2 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6| | |
| 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Basal Cell | 2 | 4 1.3|
Inflammation, Chronic Active | 2 2 | 3 2.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 50 |
Inflammation, Chronic Active | 2 | 3 1.3|
Ulcer | | 1 4.0|
Mucosa, Dilatation | 1 1 | 6 1.2|
Muscularis, Developmental | | |
Malformation | | 1 2.0|
Muscularis, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 29 |
Inflammation, Chronic | 1 1 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 50 |
Cardiomyopathy | 2 1 1 2 2 2 1 1 2 2 1 2 2 1 2 | 47 1.6|
Coronary Artery, Inflammation, | | |
Chronic Active, Necrotizing | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 50 |
Angiectasis | 1 1 2 2 1 1 1 1 1 | 28 1.4|
Congestion | 4 | 1 4.0|
Degeneration, Fatty | | 1 3.0|
Hyperplasia | 1 1 1 2 1 | 16 1.3|
Necrosis, Coagulative | | 1 3.0|
Thrombosis | | 1 3.0|
Vacuolization Cytoplasmic | 1 1 3 2 2 1 2 2 1 | 28 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 49 |
Angiectasis | 1 | 5 1.2|
Hyperplasia | 1 | 3 1.0|
Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + | 44 |
Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M | 40 |
Cyst | | 1 1.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6| | |
| 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Angiectasis | 3 3 2 2 2 4 | 14 2.3|
Pars Distalis, Cyst | 2 2 2 1 1 2 | 26 1.8|
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia | 2 1 2 2 1 2 | 18 1.6|
Pars Distalis, Pigmentation | | 1 1.0|
Pars Intermedia, Angiectasis | 1 2 2 | 5 2.0|
Pars Nervosa, Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 50 |
Ultimobranchial Cyst | 1 | 1 1.0|
C-Cell, Hyperplasia | 1 1 1 2 1 1 1 2 1 2 1 1 1 | 38 1.2|
Follicle, Cyst | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 14 |
Abscess | 2 | 1 2.0|
Cyst | 2 4 | 3 3.0|
Hyperplasia | 3 | 2 2.5|
Inflammation, Chronic | 1 1 | 6 1.0|
Inflammation, Chronic Active | | 3 3.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 50 |
Cyst | 2 | 3 3.0|
Periovarian Tissue, Cyst | 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 50 |
Hydrometra | 1 2 2 2 | 11 1.5|
Endometrium, Hyperplasia | 1 2 | 6 1.3|
Lumen, Exudate | 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + M + | 48 |
Deep Cervical, Hyperplasia, Plasma | | |
Cell | 3 | 1 3.0|
Mediastinal, Hemorrhage | 1 1 2 1 | 8 1.1|
Mediastinal, Pigmentation | | 2 1.0|
Pancreatic, Hemorrhage | | 1 3.0|
Renal, Hemorrhage | 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6| | |
| 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Infiltration Cellular | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + | 46 |
Ectasia | 3 1 1 1 | 11 1.6|
Hemorrhage | 2 1 1 1 4 | 22 2.0|
Hyperplasia, Plasma Cell | | 2 2.0|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 9 |
Hemorrhage | 4 | 1 4.0|
Infiltration Cellular, Histiocyte | 2 1 1 | 8 1.3|
Pigmentation | 1 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 50 |
Depletion Lymphoid | 2 2 | 5 2.6|
Pigmentation | | 1 2.0|
Thrombosis | 3 | 1 3.0|
Capsule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + | 8 |
Depletion Lymphoid | 2 3 | 5 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 36 |
Hyperplasia, Cystic | 4 | 1 4.0|
Hyperplasia | 4 3 3 3 3 | 13 2.5|
__________________________________________________________________________|____________|
Skin | + + | 11 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 50 |
Hydrocephalus | | 2 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 50 |
Crystals | | 1 3.0|
Hemorrhage | 1 1 | 4 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 1| 4| 7| 7| 6| 1| 1| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 2| 1| 8| 9| 6| 3| 0| 6| 9| 9| 2| 1| 0| 1| 9| 3| 2| 2| 2| 6| | |
| 3| 8| 7| 3| 4| 1| 0| 0| 3| 3| 4| 8| 0| 9| 7| 1| 9| 3| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Infiltration Cellular, Histiocyte | 1 1 1 | 14 1.1|
Inflammation, Chronic | | 1 1.0|
Metaplasia, Osseous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.0|
Artery, Mineralization | 1 1 1 1 1 1 1 1 | 24 1.0|
__________________________________________________________________________|____________|
Nose | + + | 7 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + | 6 |
Cataract | 3 3 | 5 3.4|
Synechia | | 1 4.0|
Retina, Degeneration | 4 3 | 5 3.6|
Sclera, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 49 |
Nephropathy | 3 4 2 4 4 1 2 1 2 2 2 2 1 3 1 | 48 2.1|
Collecting Tubule, Mineralization | | 1 1.0|
Renal Tubule, Hyperplasia | | 1 1.0|
Transitional Epithelium, Hyperplasia | 2 2 1 2 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 50 |
Subserosa, Mineralization | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|
| 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
Lymphoid Tissue, Hypoplasia | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
Serosa, Fibrosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 1 |
Basophilic Focus | 2 2 2 2 2 1 2 2 1 2 2 2 2 |
Clear Cell Focus | 1 1 |
Cytoplasmic Alteration | 2 |
Degeneration | |
Fatty Change | 3 2 4 3 3 1 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic, Granulomatous | 1 1 2 2 1 2 1 1 1 |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | 3 2 2 |
Necrosis, Coagulative | 3 |
Pigmentation | 1 |
Bile Duct, Hyperplasia | 2 1 1 2 1 2 1 |
Serosa, Fibrosis | |
Serosa, Hemorrhage | |
__________________________________________________________________________|
Mesentery | M + |
Fibrosis | 3 |
Inflammation, Chronic, Granulomatous | |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | |
Mineralization | |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Atrophy | 1 1 2 1 1 1 |
Cytoplasmic Alteration | 1 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 |
Pigmentation | 1 |
Artery, Perivascular, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|
| 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic, Necrotizing | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 2 1 2 |
Edema | 4 |
Hyperkeratosis | 2 2 |
Hyperplasia, Basal Cell | 2 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic Active | 4 2 3 |
Necrosis, Coagulative | 2 |
Ulcer | 4 |
Artery, Muscularis, Mineralization | 1 |
Muscularis, Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Edema | 4 |
Inflammation, Chronic Active | 3 |
Artery, Mineralization | 1 1 |
Muscularis, Mineralization | |
__________________________________________________________________________|
Tongue | + + + + M + + + + + + + + + + + + |
Hemorrhage | 1 |
Inflammation, Chronic | 1 |
Arteriole, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Cardiomyopathy | 1 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Angiectasis | 2 1 |
Atrophy | |
Pigmentation | |
Vacuolization Cytoplasmic | 2 1 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + M + + + M + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 3 4 2 2 |
Pars Distalis, Cyst | 3 1 4 2 1 1 1 |
Pars Distalis, Hyperplasia | 1 2 1 1 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|
| 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Pigmentation | |
Pars Intermedia, Angiectasis | 4 3 1 |
Pars Intermedia, Cyst | |
Pars Nervosa, Angiectasis | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 2 2 2 2 1 1 1 1 1 2 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + |
Abscess | 4 |
Cyst | |
Hyperplasia | |
Inflammation, Acute | |
Inflammation, Chronic | 1 2 1 2 2 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Hydrometra | 1 3 2 1 2 |
Inflammation, Chronic | 1 1 |
Pigmentation | |
Cervix, Cyst | |
Cervix, Inflammation, Chronic | |
Endometrium, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Pigmentation | 2 |
Renal, Ectasia | |
Renal, Hemorrhage | |
Renal, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
Congestion | |
Ectasia | 1 3 |
Hemorrhage | 3 2 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|
| 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
Infiltration Cellular, Histiocyte | 2 2 1 2 2 1 1 1 |
Pigmentation | 1 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + |
Depletion Lymphoid | 1 1 2 1 3 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Chronic, Granulomatous | 4 |
Thrombosis | |
__________________________________________________________________________|
Thymus | M + + + + + M + |
Depletion Lymphoid | 3 1 2 3 2 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + |
Galactocele | 4 |
Hyperplasia | 2 2 2 2 2 3 3 4 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Hydrocephalus | |
Meninges, Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + |
Congestion | |
Lumen, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 6| 7| 6| 6| 4| 5| 7| 6| 6| 6| 5| 7| 7| 4| 1| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 6| 2| 8| 1| 0| 0| 0| 6| 9| 2| 8| 2| 1| 1| 2| 2| 6| 9| 6| 2| 2| 2| 4| 6|
| 9| 8| 5| 0| 3| 4| 3| 3| 4| 7| 3| 0| 6| 2| 5| 8| 5| 4| 1| 4| 9| 9| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + I I I + |
Cataract | 4 |
Synechia | 4 4 |
Cornea, Fibrosis | 3 |
Retina, Degeneration | 3 3 |
__________________________________________________________________________|
Harderian Gland | + + |
Hemorrhage | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Congestion | |
Inflammation, Chronic | |
Nephropathy | 3 2 2 1 2 1 2 3 2 2 1 3 1 1 3 2 3 2 1 4 |
Artery, Fibrosis | |
Proximal Convoluted Renal Tubule, | |
Degeneration, Hyaline | |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 1 |
Proximal Convoluted Renal Tubule, | |
Pigmentation | 4 |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | 1 2 1 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|
DAY ON TEST | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|
| 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0.1% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + |
Lymphoid Tissue, Hypoplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + |
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + M + + + + + + |
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + |
Angiectasis | 1 2 |
Basophilic Focus | 3 2 1 2 2 1 2 1 2 2 1 1 2 2 2 |
Clear Cell Focus | 2 1 |
Cytoplasmic Alteration | 1 1 |
Degeneration | |
Fatty Change | 2 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic, Granulomatous | 2 1 2 1 1 1 |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | 1 |
Necrosis, Coagulative | 1 |
Pigmentation | |
Bile Duct, Hyperplasia | 1 1 1 1 1 |
Serosa, Fibrosis | 1 |
Serosa, Hemorrhage | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 3 2 3 |
Inflammation, Chronic, Granulomatous | 2 |
Inflammation, Chronic | 3 3 |
Inflammation, Chronic Active | |
Mineralization | 1 |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + |
Atrophy | 1 1 1 1 1 3 1 2 1 2 |
Cytoplasmic Alteration | 1 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 |
Pigmentation | |
Artery, Perivascular, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|
DAY ON TEST | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|
| 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0.1% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic, Necrotizing | 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + |
Acanthosis | |
Edema | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
Ulcer | |
Artery, Muscularis, Mineralization | |
Muscularis, Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + |
Edema | |
Inflammation, Chronic Active | |
Artery, Mineralization | |
Muscularis, Mineralization | |
__________________________________________________________________________|
Tongue | + + + + + + M + + M + + + + + + + |
Hemorrhage | |
Inflammation, Chronic | 1 1 1 1 |
Arteriole, Necrosis, Fibrinoid | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
Cardiomyopathy | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + |
Angiectasis | |
Atrophy | |
Pigmentation | |
Vacuolization Cytoplasmic | 1 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M M + + M + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 2 2 3 1 2 3 4 |
Pars Distalis, Cyst | 2 2 2 2 3 2 3 2 2 |
Pars Distalis, Hyperplasia | 3 2 1 2 2 2 2 2 1 2 1 3 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|
DAY ON TEST | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|
| 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0.1% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Pigmentation | 1 2 |
Pars Intermedia, Angiectasis | 1 1 4 |
Pars Intermedia, Cyst | 2 |
Pars Nervosa, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 3 1 1 1 1 1 1 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + |
Abscess | |
Cyst | |
Hyperplasia | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + |
Periovarian Tissue, Cyst | 3 4 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + |
Hydrometra | 2 |
Inflammation, Chronic | |
Pigmentation | |
Cervix, Cyst | |
Cervix, Inflammation, Chronic | |
Endometrium, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Mediastinal, Hemorrhage | 4 4 |
Mediastinal, Pigmentation | |
Renal, Ectasia | 3 2 |
Renal, Hemorrhage | |
Renal, Infiltration Cellular, | |
Histiocyte | 3 |
Renal, Pigmentation | 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Congestion | |
Ectasia | 2 3 2 |
Hemorrhage | 4 2 1 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|
DAY ON TEST | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|
| 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0.1% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Infiltration Cellular, Histiocyte | 1 2 2 |
Pigmentation | 1 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + |
Depletion Lymphoid | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic, Granulomatous | 3 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + |
Depletion Lymphoid | 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + |
Galactocele | |
Hyperplasia | 3 2 4 3 2 4 3 |
__________________________________________________________________________|
Skin | + + + + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Hydrocephalus | |
Meninges, Hemorrhage | 2 |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Mineralization | 1 |
__________________________________________________________________________|
Nose | + + + |
Congestion | 4 |
Lumen, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 7| 1| 7| 4| 7| 7| 7| 6| 4| 7| 7| 1| 6| 5| 7| 7| 7| 7| 4| 1| 7| 5| 4| 1|
DAY ON TEST | 9| 2| 9| 2| 9| 2| 2| 2| 8| 6| 3| 2| 9| 8| 4| 2| 2| 3| 2| 6| 9| 2| 4| 6| 9|
| 1| 3| 1| 5| 7| 3| 3| 9| 3| 4| 1| 4| 1| 7| 3| 3| 3| 1| 4| 6| 1| 1| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
0.1% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + I |
Cataract | 4 |
Synechia | |
Cornea, Fibrosis | 2 |
Retina, Degeneration | 2 4 3 |
__________________________________________________________________________|
Harderian Gland | + |
Hemorrhage | 1 |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + |
Autolysis | |
Congestion | 3 |
Inflammation, Chronic | 2 |
Nephropathy | 4 3 2 3 2 4 2 2 2 2 2 2 3 2 3 2 2 |
Artery, Fibrosis | 2 |
Proximal Convoluted Renal Tubule, | |
Degeneration, Hyaline | 4 |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 1 |
Proximal Convoluted Renal Tubule, | |
Pigmentation | |
Renal Tubule, Hyperplasia | 1 |
Transitional Epithelium, Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4| | |
DAY ON TEST | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6| | |
| 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 12 |
__________________________________________________________________________|____________|
Intestine Large | + A | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A | 11 |
Lymphoid Tissue, Hypoplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + A | 11 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A A + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A A + + + | 48 |
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A A + + + | 47 |
Autolysis | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 50 |
Angiectasis | 2 | 5 1.6|
Basophilic Focus | 1 1 1 2 2 1 2 2 2 2 | 38 1.7|
Clear Cell Focus | | 4 1.3|
Cytoplasmic Alteration | 1 | 4 1.3|
Degeneration | 4 | 1 4.0|
Fatty Change | 3 3 1 | 12 2.5|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 3 |
Inflammation, Chronic, Granulomatous | 1 1 | 17 1.3|
Inflammation, Chronic Active | | 2 1.0|
Mixed Cell Focus | 2 1 3 | 7 2.0|
Necrosis, Coagulative | 1 1 1 | 5 1.4|
Pigmentation | | 1 1.0|
Bile Duct, Hyperplasia | 1 1 | 14 1.2|
Serosa, Fibrosis | | 1 1.0|
Serosa, Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Fibrosis | 3 2 | 6 2.7|
Inflammation, Chronic, Granulomatous | | 1 2.0|
Inflammation, Chronic | | 3 3.0|
Inflammation, Chronic Active | 3 3 | 2 3.0|
Mineralization | | 1 1.0|
Necrosis, Coagulative | 2 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4| | |
DAY ON TEST | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6| | |
| 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy | 1 1 1 2 1 | 21 1.3|
Cytoplasmic Alteration | | 2 1.0|
Inflammation, Chronic | 1 1 1 1 1 | 22 1.0|
Pigmentation | | 1 1.0|
Artery, Perivascular, Inflammation, | | |
Chronic, Necrotizing | | 1 2.0|
Duct, Dilatation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 50 |
Acanthosis | | 3 1.7|
Edema | | 1 4.0|
Hyperkeratosis | | 2 2.0|
Hyperplasia, Basal Cell | | 2 2.0|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic Active | | 3 3.0|
Necrosis, Coagulative | | 1 2.0|
Ulcer | | 1 4.0|
Artery, Muscularis, Mineralization | | 1 1.0|
Muscularis, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + | 49 |
Edema | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
Artery, Mineralization | 2 | 3 1.3|
Muscularis, Mineralization | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Tongue | + + + + + M + + + + + + + | 43 |
Hemorrhage | 2 | 2 1.5|
Inflammation, Chronic | 1 1 | 7 1.0|
Arteriole, Necrosis, Fibrinoid | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 13 |
Cardiomyopathy | 2 | 9 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + | 13 |
Angiectasis | | 2 1.5|
Atrophy | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4| | |
DAY ON TEST | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6| | |
| 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pigmentation | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 | 8 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + | 13 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A | 15 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + M M + + | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + | 49 |
Pars Distalis, Angiectasis | | 11 2.5|
Pars Distalis, Cyst | 1 3 1 4 2 | 21 2.1|
Pars Distalis, Hyperplasia | 2 3 3 1 | 23 1.8|
Pars Distalis, Pigmentation | 1 | 3 1.3|
Pars Intermedia, Angiectasis | | 6 2.3|
Pars Intermedia, Cyst | 1 | 2 1.5|
Pars Nervosa, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 43 |
C-Cell, Hyperplasia | 1 2 1 1 1 1 1 2 1 1 | 37 1.3|
Follicular Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + | 20 |
Abscess | 3 | 2 3.5|
Cyst | 2 3 | 2 2.5|
Hyperplasia | 3 | 1 3.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 1 | 10 1.3|
Inflammation, Chronic Active | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + M + | 17 |
Periovarian Tissue, Cyst | | 3 3.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + | 50 |
Hydrometra | 1 2 1 | 9 1.7|
Inflammation, Chronic | | 2 1.0|
Pigmentation | 1 | 1 1.0|
Cervix, Cyst | 2 | 1 2.0|
Cervix, Inflammation, Chronic | 1 | 1 1.0|
Endometrium, Hyperplasia | 1 1 | 7 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4| | |
DAY ON TEST | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6| | |
| 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + A | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 25 |
Mediastinal, Hemorrhage | | 3 3.7|
Mediastinal, Pigmentation | | 1 2.0|
Renal, Ectasia | | 2 2.5|
Renal, Hemorrhage | 1 | 1 1.0|
Renal, Infiltration Cellular, | | |
Histiocyte | 2 | 3 2.3|
Renal, Pigmentation | 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 19 |
Congestion | 1 | 1 1.0|
Ectasia | | 5 2.2|
Hemorrhage | 1 | 6 2.2|
Infiltration Cellular, Histiocyte | 2 1 | 2 1.5|
Pigmentation | 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 14 |
Infiltration Cellular, Histiocyte | 1 1 1 | 14 1.4|
Pigmentation | 1 1 1 | 14 1.1|
__________________________________________________________________________|____________|
Spleen | + + + | 23 |
Depletion Lymphoid | | 5 1.6|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Inflammation, Chronic, Granulomatous | | 2 3.5|
Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + M | 10 |
Depletion Lymphoid | 2 | 7 2.1|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 36 |
Galactocele | | 1 4.0|
Hyperplasia | 2 4 2 3 | 20 2.8|
__________________________________________________________________________|____________|
Skin | + + | 15 |
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4| | |
DAY ON TEST | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6| | |
| 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 15 |
Hydrocephalus | 2 | 1 2.0|
Meninges, Hemorrhage | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 20 |
Hemorrhage | 1 | 3 1.0|
Infiltration Cellular, Histiocyte | | 5 1.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Artery, Mineralization | | 3 1.0|
__________________________________________________________________________|____________|
Nose | + + | 12 |
Congestion | | 1 4.0|
Lumen, Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | I + + I | 8 |
Cataract | | 2 4.0|
Synechia | 2 | 3 3.3|
Cornea, Fibrosis | | 2 2.5|
Retina, Degeneration | 2 | 6 2.8|
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Hemorrhage | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 | 3 1.3|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + | 49 |
Autolysis | 3 | 1 3.0|
Congestion | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Nephropathy | 2 2 3 3 2 2 2 1 4 3 2 | 48 2.3|
Artery, Fibrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 1| 1| 5| 4| 7| 7| 1| 7| 6| 7| 7| 6| 5| 4| 7| 1| 7| 7| 4| | |
DAY ON TEST | 3| 9| 9| 9| 6| 3| 3| 9| 2| 9| 2| 2| 7| 0| 6| 2| 9| 2| 2| 6| | |
| 1| 3| 3| 6| 4| 1| 1| 3| 5| 6| 5| 5| 6| 4| 4| 3| 3| 5| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.1% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Proximal Convoluted Renal Tubule, | | |
Degeneration, Hyaline | | 1 4.0|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | | 4 1.0|
Proximal Convoluted Renal Tubule, | | |
Pigmentation | | 1 4.0|
Renal Tubule, Hyperplasia | | 1 1.0|
Transitional Epithelium, Hyperplasia | 2 1 | 9 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + | 49 |
Inflammation, Chronic | | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|
| 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + |
Autolysis | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + + + + |
Epithelium, Pigmentation | 1 2 1 2 2 1 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + + + + + |
Autolysis | 4 |
Epithelium, Pigmentation | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Basophilic Focus | 1 1 2 1 2 2 2 2 1 1 2 2 1 2 |
Clear Cell Focus | |
Cyst Multilocular | |
Degeneration | |
Fatty Change | 1 1 1 2 |
Granuloma | |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic, Granulomatous | 1 2 1 1 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | 1 |
Necrosis, Coagulative | 1 |
Pigmentation | |
Bile Duct, Hyperplasia | 2 1 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | 4 |
Inflammation, Chronic, Granulomatous | |
Mineralization | 2 |
Pigmentation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Atrophy | 1 1 1 1 2 |
Cytoplasmic Alteration | 1 1 |
Inflammation, Chronic | 1 1 1 |
Artery, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|
| 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Acanthosis | 1 2 1 |
Hyperkeratosis | 3 |
Hyperplasia, Basal Cell | 1 1 1 |
Inflammation, Chronic Active, | |
Necrotizing | 4 |
Artery, Mineralization | |
Muscularis, Mineralization | 1 1 |
Submucosa, Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
Artery, Mineralization | 2 |
Epithelium, Pigmentation | 1 1 1 |
Mucosa, Dilatation | 1 2 2 2 1 |
Muscularis, Mineralization | 2 1 1 |
__________________________________________________________________________|
Tongue | + + + M + + + + + + + + M + + + + |
Hemorrhage | 2 |
Inflammation, Chronic | 1 1 1 1 1 |
Arteriole, Necrosis, Fibrinoid | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
Angiectasis | 1 |
Congestion | 2 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
Angiectasis | 4 |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + + + + + + M M + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 2 2 2 3 |
Pars Distalis, Cyst | 2 2 2 2 2 2 |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 1 |
Pars Distalis, Infiltration Cellular,| |
Histiocyte | 1 |
Pars Distalis, Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|
| 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Angiectasis | 2 1 |
Pars Intermedia, Cyst | 1 X 1 |
Pars Intermedia, Pigmentation | |
Pars Nervosa, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 2 1 2 3 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + |
Cyst | |
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Ovary | + M M + M M M M M + M M M M M + M + |
Congestion | |
Periovarian Tissue, Cyst | 3 4 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + |
Cyst | 3 2 |
Hydrometra | 3 3 |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia | 1 2 2 1 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Pigmentation | |
Pancreatic, Ectasia | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Pigmentation | 2 |
Renal, Hemorrhage | 1 |
Renal, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + |
Hemorrhage | 2 3 |
Infiltration Cellular, Histiocyte | 2 |
Necrosis, Coagulative | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|
| 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | |
Ectasia | 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 2 |
Pigmentation | 1 1 |
Thrombosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic, Granulomatous | 3 |
__________________________________________________________________________|
Thymus | + |
Depletion Lymphoid | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + |
Galactocele | 2 |
Hyperplasia | 3 3 1 |
__________________________________________________________________________|
Skin | + + |
Inflammation, Acute, Necrotizing | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + |
Foreign Body | 1 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 2 |
Inflammation, Chronic Active | 2 |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Mineralization | 1 |
__________________________________________________________________________|
Nose | + |
Glands, Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 1| 7| 6| 4| 1| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 3| 9| 1| 0| 2| 2| 2| 6| 6| 9| 2| 6| 6| 9| 2| 2| 2| 0| 6| 2| 2| 2| 2| 6|
| 4| 1| 1| 8| 7| 9| 4| 5| 6| 4| 1| 3| 6| 4| 1| 4| 4| 9| 9| 0| 3| 4| 4| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Synechia | 4 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Hemorrhage | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Inflammation, Chronic | |
Nephropathy | 2 2 2 4 3 2 1 2 2 2 2 3 3 2 3 2 2 1 |
Artery, Thrombosis | |
Papilla, Necrosis, Coagulative | |
Proximal Convoluted Renal Tubule, | |
Pigmentation | |
Renal Tubule, Hyperplasia, Cystic | 3 |
Renal Tubule, Hyperplasia | 1 2 2 |
Transitional Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|
DAY ON TEST | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|
| 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% MF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
Epithelium, Pigmentation | 1 1 1 1 2 1 1 2 1 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Epithelium, Pigmentation | 1 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Basophilic Focus | 2 1 1 2 1 1 1 1 1 1 2 1 2 2 2 2 1 1 |
Clear Cell Focus | 1 1 1 |
Cyst Multilocular | 3 |
Degeneration | 2 |
Fatty Change | 1 2 1 |
Granuloma | 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Acute | |
Inflammation, Chronic, Granulomatous | 1 1 1 1 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Mixed Cell Focus | 2 4 2 |
Necrosis, Coagulative | 1 1 |
Pigmentation | 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | |
Fibrosis | |
Inflammation, Chronic, Granulomatous | |
Mineralization | |
Pigmentation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Atrophy | 2 1 1 1 1 1 1 1 2 1 1 2 |
Cytoplasmic Alteration | 1 2 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Artery, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|
DAY ON TEST | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|
| 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% MF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Inflammation, Chronic Active, | |
Necrotizing | |
Artery, Mineralization | |
Muscularis, Mineralization | |
Submucosa, Mineralization | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Artery, Mineralization | |
Epithelium, Pigmentation | 1 2 2 2 |
Mucosa, Dilatation | |
Muscularis, Mineralization | 3 2 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + M + + + + + |
Hemorrhage | |
Inflammation, Chronic | 1 1 1 1 1 |
Arteriole, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
Cardiomyopathy | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + M + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
Angiectasis | |
Congestion | |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
Angiectasis | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M + M + M + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 3 3 1 2 2 |
Pars Distalis, Cyst | 1 2 4 2 1 1 2 1 2 |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Hyperplasia | 1 2 3 3 2 2 2 1 2 |
Pars Distalis, Infiltration Cellular,| |
Histiocyte | |
Pars Distalis, Pigmentation | 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|
DAY ON TEST | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|
| 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% MF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Angiectasis | 3 1 |
Pars Intermedia, Cyst | 2 1 2 1 |
Pars Intermedia, Pigmentation | |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + |
Cyst | 3 |
Inflammation, Acute | |
Inflammation, Chronic | 1 2 |
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Ovary | + M M M M M M M M + M M M M + + M M + |
Congestion | |
Periovarian Tissue, Cyst | 4 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Cyst | 2 |
Hydrometra | 3 |
Inflammation, Chronic Active | 1 |
Endometrium, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + |
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | |
Pancreatic, Ectasia | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation | |
Renal, Hemorrhage | |
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + |
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|
DAY ON TEST | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|
| 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% MF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Angiectasis | |
Ectasia | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 1 2 |
Pigmentation | 1 1 1 |
Thrombosis | |
__________________________________________________________________________|
Spleen | + + + + + + |
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 4 |
Inflammation, Chronic, Granulomatous | 3 3 |
__________________________________________________________________________|
Thymus | + + |
Depletion Lymphoid | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
Galactocele | |
Hyperplasia | 2 3 3 3 2 2 |
__________________________________________________________________________|
Skin | + + |
Inflammation, Acute, Necrotizing | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
Hydrocephalus | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Foreign Body | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic Active | |
Leukocytosis | |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Mineralization | 1 1 |
__________________________________________________________________________|
Nose | + + |
Glands, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 1|
DAY ON TEST | 3| 2| 2| 6| 2| 2| 2| 9| 3| 2| 2| 2| 2| 6| 6| 2| 3| 2| 0| 6| 2| 2| 2| 0| 9|
| 1| 9| 4| 4| 4| 4| 4| 1| 1| 9| 4| 4| 5| 6| 6| 4| 1| 5| 3| 4| 3| 9| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
1.0% MF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 4 |
Synechia | 3 4 |
Retina, Degeneration | 4 2 4 |
__________________________________________________________________________|
Harderian Gland | |
Hemorrhage | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Inflammation, Chronic | |
Nephropathy | 3 1 2 2 2 3 2 2 2 2 1 2 2 2 2 2 2 3 1 |
Artery, Thrombosis | |
Papilla, Necrosis, Coagulative | 2 |
Proximal Convoluted Renal Tubule, | |
Pigmentation | |
Renal Tubule, Hyperplasia, Cystic | |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4| | |
DAY ON TEST | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4| | |
| 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 7 |
Parasite Metazoan | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + | 50 |
Autolysis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + | 49 |
Epithelium, Pigmentation | 2 1 | 19 1.3|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + | 49 |
Autolysis | | 1 4.0|
Epithelium, Pigmentation | | 3 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | 1 2 1 1 1 2 1 1 1 | 41 1.4|
Clear Cell Focus | 1 | 4 1.0|
Cyst Multilocular | | 1 3.0|
Degeneration | | 1 2.0|
Fatty Change | 1 2 2 2 4 | 12 1.7|
Granuloma | | 1 1.0|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 5 1.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic, Granulomatous | | 10 1.1|
Inflammation, Chronic | 1 2 | 3 1.3|
Inflammation, Chronic Active | 1 | 2 1.0|
Mixed Cell Focus | | 4 2.3|
Necrosis, Coagulative | 1 1 | 5 1.0|
Pigmentation | | 1 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 | 17 1.1|
__________________________________________________________________________|____________|
Mesentery | + M | 2 |
Fibrosis | | 1 4.0|
Inflammation, Chronic, Granulomatous | 4 | 1 4.0|
Mineralization | | 1 2.0|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + | 50 |
Atrophy | 2 2 1 1 | 21 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4| | |
DAY ON TEST | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4| | |
| 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cytoplasmic Alteration | | 4 1.3|
Inflammation, Chronic | 1 1 1 1 | 22 1.0|
Artery, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 7 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 50 |
Acanthosis | | 3 1.3|
Hyperkeratosis | | 1 3.0|
Hyperplasia, Basal Cell | | 3 1.0|
Inflammation, Chronic Active, | | |
Necrotizing | | 1 4.0|
Artery, Mineralization | 1 | 1 1.0|
Muscularis, Mineralization | 1 | 3 1.0|
Submucosa, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + | 50 |
Artery, Mineralization | | 1 2.0|
Epithelium, Pigmentation | 1 | 8 1.4|
Mucosa, Dilatation | | 5 1.6|
Muscularis, Mineralization | 1 | 6 1.7|
__________________________________________________________________________|____________|
Tongue | + + + M M + + + + M + + + | 43 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 1 1 | 12 1.0|
Arteriole, Necrosis, Fibrinoid | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 7 |
Cardiomyopathy | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 13 |
Angiectasis | 1 | 2 1.0|
Congestion | | 1 2.0|
Hyperplasia | | 2 1.0|
Vacuolization Cytoplasmic | 1 3 4 | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + | 12 |
Angiectasis | | 1 4.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4| | |
DAY ON TEST | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4| | |
| 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M + M + M + + + M | 36 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + | 50 |
Pars Distalis, Angiectasis | 1 4 2 | 12 2.3|
Pars Distalis, Cyst | 1 4 3 1 2 2 2 2 | 23 2.0|
Pars Distalis, Cyst, Multiple | X | 1 |
Pars Distalis, Hyperplasia | 1 2 1 | 18 1.8|
Pars Distalis, Infiltration Cellular,| | |
Histiocyte | | 1 1.0|
Pars Distalis, Pigmentation | 1 | 3 1.7|
Pars Intermedia, Angiectasis | | 4 1.8|
Pars Intermedia, Cyst | | 7 1.3|
Pars Intermedia, Pigmentation | 1 | 1 1.0|
Pars Nervosa, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + | 47 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 | 40 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M | 14 |
Cyst | | 1 3.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | 1 | 4 1.3|
Inflammation, Chronic Active | | 3 3.3|
__________________________________________________________________________|____________|
Ovary | M M M + M + + M M M + M + | 15 |
Congestion | 2 | 1 2.0|
Periovarian Tissue, Cyst | 3 2 | 9 3.2|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + | 50 |
Cyst | | 3 2.3|
Hydrometra | 3 1 | 5 2.6|
Inflammation, Chronic Active | | 1 1.0|
Endometrium, Hyperplasia | 1 | 8 1.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4| | |
DAY ON TEST | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4| | |
| 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hemorrhage | 1 2 | 3 2.0|
Mediastinal, Pigmentation | 2 | 1 2.0|
Pancreatic, Ectasia | 3 | 1 3.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.0|
Pancreatic, Pigmentation | 1 | 2 1.5|
Renal, Hemorrhage | 2 | 2 1.5|
Renal, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.0|
Renal, Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + | 10 |
Hemorrhage | 4 | 3 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Necrosis, Coagulative | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 12 |
Angiectasis | 4 | 1 4.0|
Ectasia | | 1 2.0|
Hemorrhage | 1 | 2 1.5|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 10 1.3|
Pigmentation | 1 1 1 | 8 1.0|
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 20 |
Depletion Lymphoid | 2 2 | 4 2.3|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 3 3.3|
Inflammation, Chronic, Granulomatous | | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + | 7 |
Depletion Lymphoid | 2 | 1 2.0|
Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + | 24 |
Galactocele | | 1 2.0|
Hyperplasia | 2 2 3 2 | 13 2.4|
__________________________________________________________________________|____________|
Skin | + + + + | 8 |
Inflammation, Acute, Necrotizing | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4| | |
DAY ON TEST | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4| | |
| 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 8 |
Hydrocephalus | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 20 |
Foreign Body | | 1 1.0|
Hemorrhage | 2 2 | 2 2.0|
Infiltration Cellular, Histiocyte | | 3 1.3|
Inflammation, Chronic Active | | 1 2.0|
Leukocytosis | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Artery, Mineralization | 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Nose | + + + + | 7 |
Glands, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + | 7 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + I + | 6 |
Cataract | | 3 3.7|
Synechia | | 3 3.7|
Retina, Degeneration | | 4 3.5|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Hemorrhage | 1 | 1 1.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 50 |
Autolysis | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Nephropathy | 3 3 2 1 2 2 1 2 3 2 1 2 1 | 50 2.1|
Artery, Thrombosis | 2 | 1 2.0|
Papilla, Necrosis, Coagulative | | 1 2.0|
Proximal Convoluted Renal Tubule, | | |
Pigmentation | 2 | 1 2.0|
Renal Tubule, Hyperplasia, Cystic | | 1 3.0|
Renal Tubule, Hyperplasia | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 6| 1| 5| 3| 7| 7| 6| 5| 1| 1| 6| 4| 1| 4| | |
DAY ON TEST | 2| 9| 2| 2| 6| 2| 9| 9| 4| 3| 2| 2| 9| 4| 9| 9| 8| 6| 9| 4| | |
| 3| 3| 9| 5| 6| 3| 7| 3| 8| 7| 3| 5| 7| 8| 3| 3| 5| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
1.0% MF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Transitional Epithelium, Hyperplasia | 2 | 5 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|
| 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + M + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + |
Necrosis, Acute, Coagulative | |
Parasite Metazoan | X 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + |
Epithelium, Pigmentation | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + |
Epithelium, Pigmentation | 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + |
Epithelium, Pigmentation | 2 2 1 2 1 1 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Clear Cell Focus | |
Cyst | |
Cytoplasmic Alteration | 3 |
Developmental Malformation | X X |
Eosinophilic Focus | |
Fatty Change | 3 1 1 |
Fibrosis, Focal | |
Infarct | |
Inflammation, Chronic, Granulomatous | 1 1 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 1 |
Bile Duct, Cyst Multilocular | |
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 |
Centrilobular, Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Atrophy | 2 1 1 1 1 1 |
Cytoplasmic Alteration | |
Ectopic Liver | X |
Inflammation, Chronic | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Acanthosis | 2 1 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|
| 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | |
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 2 |
Inflammation, Chronic Active | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | |
Epithelium, Pigmentation | 2 2 1 1 2 2 1 2 1 1 2 1 2 2 2 2 2 |
Mucosa, Dilatation | 1 |
Muscularis, Mineralization | 1 1 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 4 2 1 1 1 1 2 1 2 1 2 1 1 1 2 2 1 1 1 2 |
Atrium Left, Thrombosis | |
Coronary Artery, Inflammation, | |
Chronic Active | |
Coronary Artery, Necrosis, Fibrinoid | |
Epicardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 1 1 1 1 1 2 1 1 1 1 |
Hyperplasia | 1 1 1 2 1 1 1 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 1 1 2 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + |
Angiectasis | 1 |
Hyperplasia | |
Pars Distalis, Angiectasis | 3 1 2 2 1 |
Pars Distalis, Cyst | 1 1 1 4 1 3 2 1 1 1 3 3 2 2 |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Hyperplasia | 1 1 1 1 2 2 2 1 2 |
Pars Intermedia, Angiectasis | 3 2 1 1 |
Pars Intermedia, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|
| 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + |
Abscess | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + M + |
Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Hydrometra | 1 1 2 2 3 3 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
Metaplasia, Squamous | |
Endometrium, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + M |
Lumbar, Infiltration Cellular, | |
Histiocyte | |
Lumbar, Pigmentation | |
Mediastinal, Depletion Lymphoid | 4 |
Mediastinal, Hemorrhage | 1 1 1 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Necrosis, Coagulative | |
Mediastinal, Pigmentation | |
Pancreatic, Ectasia | |
Pancreatic, Hemorrhage | 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation | 2 |
Renal, Hemorrhage | |
Renal, Infiltration Cellular, | |
Histiocyte | 3 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + M + + + + + + + M |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|
| 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Ectasia | 1 2 2 |
Hemorrhage | 2 1 4 3 1 2 1 |
Infiltration Cellular, Histiocyte | 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + |
Ectasia | 3 |
Infiltration Cellular, Histiocyte | 2 1 |
Necrosis, Coagulative | |
Pigmentation | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | 2 3 1 3 4 1 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic, Granulomatous | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + M |
Depletion Lymphoid | 3 3 |
Necrosis, Coagulative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + |
Galactocele | |
Hyperplasia | 1 2 2 1 2 |
__________________________________________________________________________|
Skin | + + + |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 1 1 |
Hydrocephalus | |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 7| 5| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 8| 9| 6| 1| 9| 2| 2| 9| 1| 2| 5| 6| 2| 2| 3| 3| 2| 2| 6| 3| 2| 3| 6| 6|
| 4| 8| 2| 4| 6| 1| 3| 4| 1| 5| 3| 3| 0| 5| 3| 1| 1| 5| 4| 8| 1| 4| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Mineralization | 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + A + |
Capillary, Submucosa, Thrombosis | |
Glands, Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | |
Retina, Degeneration | |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Nephropathy | 3 3 2 2 3 4 3 2 2 2 2 3 2 2 1 2 2 2 |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Inflammation, Acute | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|
| 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
Necrosis, Acute, Coagulative | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
Epithelium, Pigmentation | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
Epithelium, Pigmentation | 2 1 1 1 1 1 2 2 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
Epithelium, Pigmentation | 1 1 1 1 2 2 2 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 |
Clear Cell Focus | 1 1 |
Cyst | 2 |
Cytoplasmic Alteration | |
Developmental Malformation | |
Eosinophilic Focus | 2 |
Fatty Change | 1 1 |
Fibrosis, Focal | 2 |
Infarct | |
Inflammation, Chronic, Granulomatous | 1 1 1 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | |
Mixed Cell Focus | 1 |
Necrosis, Coagulative | 1 1 |
Bile Duct, Cyst Multilocular | X |
Bile Duct, Hyperplasia | 1 1 1 1 |
Centrilobular, Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Atrophy | 1 3 1 1 |
Cytoplasmic Alteration | 1 2 |
Ectopic Liver | |
Inflammation, Chronic | 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
Acanthosis | 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|
| 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | |
Hyperkeratosis | 2 2 1 |
Hyperplasia, Basal Cell | 2 2 1 |
Inflammation, Chronic Active | 4 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | 3 |
Inflammation, Chronic Active | 2 |
Epithelium, Pigmentation | 1 2 1 2 1 2 2 2 2 2 1 |
Mucosa, Dilatation | 1 2 1 |
Muscularis, Mineralization | 1 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Cardiomyopathy | 1 1 1 1 1 1 1 2 4 2 1 1 2 2 |
Atrium Left, Thrombosis | 4 |
Coronary Artery, Inflammation, | |
Chronic Active | 4 |
Coronary Artery, Necrosis, Fibrinoid | |
Epicardium, Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + |
Angiectasis | 1 1 1 2 2 1 2 1 1 |
Hyperplasia | 1 1 2 3 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M M M M + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Angiectasis | |
Hyperplasia | |
Pars Distalis, Angiectasis | 1 1 |
Pars Distalis, Cyst | 2 4 3 1 2 2 |
Pars Distalis, Cyst, Multiple | 3 |
Pars Distalis, Hyperplasia | 1 1 |
Pars Intermedia, Angiectasis | 3 3 |
Pars Intermedia, Cyst | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|
| 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 |
Follicle, Cyst | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + |
Abscess | 4 |
Inflammation, Chronic | 2 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + |
Cyst | 2 |
Periovarian Tissue, Cyst | 3 1 X 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Hydrometra | 3 2 2 3 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
Metaplasia, Squamous | |
Endometrium, Hyperplasia | 2 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + |
Lumbar, Infiltration Cellular, | |
Histiocyte | |
Lumbar, Pigmentation | |
Mediastinal, Depletion Lymphoid | |
Mediastinal, Hemorrhage | 2 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Necrosis, Coagulative | 4 |
Mediastinal, Pigmentation | 2 |
Pancreatic, Ectasia | |
Pancreatic, Hemorrhage | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation | |
Renal, Hemorrhage | |
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|
| 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Ectasia | |
Hemorrhage | 1 2 3 2 |
Infiltration Cellular, Histiocyte | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + |
Ectasia | |
Infiltration Cellular, Histiocyte | 2 1 1 1 |
Necrosis, Coagulative | |
Pigmentation | 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Depletion Lymphoid | 2 3 4 |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Chronic, Granulomatous | 2 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + M + + |
Depletion Lymphoid | 3 2 3 |
Necrosis, Coagulative | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
Galactocele | 3 |
Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + |
Subcutaneous Tissue, Edema | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
Hemorrhage | |
Hydrocephalus | 2 |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 |
Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 4| 1| 5| 4| 2| 1| 7| 7| 6| 1| 4| 7| 7| 7| 5| 4| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 2| 9| 2| 6| 9| 9| 6| 8| 9| 3| 2| 3| 9| 5| 2| 2| 1| 9| 6| 9| 2| 6| 2| 6|
| 1| 4| 1| 4| 6| 1| 7| 6| 4| 1| 1| 4| 0| 3| 7| 3| 3| 6| 4| 4| 3| 3| 7| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
4.0% HF | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + |
Capillary, Submucosa, Thrombosis | |
Glands, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Retina, Degeneration | 3 |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Congestion | 2 |
Nephropathy | 3 2 3 2 1 3 3 2 1 3 4 2 2 1 2 1 |
Renal Tubule, Hyperplasia | 1 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
Hemorrhage | 4 |
Inflammation, Acute | 3 |
Transitional Epithelium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4| | |
DAY ON TEST | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6| | |
| 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + | 48 |
Necrosis, Acute, Coagulative | 2 | 1 2.0|
Parasite Metazoan | 1 | 4 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 48 |
Parasite Metazoan | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + | 47 |
Parasite Metazoan | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 49 |
Epithelium, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + | 49 |
Epithelium, Pigmentation | 1 2 2 2 2 1 1 1 | 32 1.6|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + | 49 |
Epithelium, Pigmentation | 1 1 1 1 1 | 20 1.4|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 50 |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 | 39 1.0|
Clear Cell Focus | | 2 1.0|
Cyst | 4 | 2 3.0|
Cytoplasmic Alteration | | 1 3.0|
Developmental Malformation | | 2 |
Eosinophilic Focus | 1 4 | 3 2.3|
Fatty Change | 1 1 | 7 1.3|
Fibrosis, Focal | | 1 2.0|
Infarct | 4 | 1 4.0|
Inflammation, Chronic, Granulomatous | 2 1 | 8 1.1|
Inflammation, Chronic | 1 | 3 1.0|
Inflammation, Chronic Active | 1 1 1 | 7 1.0|
Mixed Cell Focus | | 1 1.0|
Necrosis, Coagulative | 1 1 3 1 | 8 1.3|
Bile Duct, Cyst Multilocular | | 1 |
Bile Duct, Hyperplasia | 1 2 2 | 15 1.2|
Centrilobular, Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 50 |
Atrophy | 3 1 1 1 1 | 15 1.3|
Cytoplasmic Alteration | | 2 1.5|
Ectopic Liver | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4| | |
DAY ON TEST | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6| | |
| 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 1 1 1 1 1 | 17 1.1|
__________________________________________________________________________|____________|
Salivary Glands | + + | 11 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 47 |
Acanthosis | 2 2 | 7 2.0|
Edema | 4 | 1 4.0|
Hyperkeratosis | 2 2 2 | 7 1.9|
Hyperplasia, Basal Cell | 1 | 5 1.6|
Inflammation, Chronic Active | 2 | 2 3.0|
Ulcer | 2 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 50 |
Cyst Epithelial Inclusion | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Epithelium, Pigmentation | 1 2 2 2 1 2 2 2 1 2 | 38 1.7|
Mucosa, Dilatation | | 4 1.3|
Muscularis, Mineralization | 1 | 4 1.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 39 |
Inflammation, Chronic | 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 50 |
Cardiomyopathy | 2 2 2 2 2 2 1 1 1 1 1 1 2 | 47 1.5|
Atrium Left, Thrombosis | | 1 4.0|
Coronary Artery, Inflammation, | | |
Chronic Active | | 1 4.0|
Coronary Artery, Necrosis, Fibrinoid | 2 | 1 2.0|
Epicardium, Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 50 |
Angiectasis | 2 2 1 1 1 2 | 26 1.3|
Hyperplasia | 2 1 1 2 | 15 1.4|
Necrosis, Coagulative | 2 | 1 2.0|
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 | 24 1.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 50 |
Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + | 43 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4| | |
DAY ON TEST | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6| | |
| 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + | 49 |
Angiectasis | | 1 1.0|
Hyperplasia | 1 1 | 2 1.0|
Pars Distalis, Angiectasis | 1 | 8 1.5|
Pars Distalis, Cyst | 1 2 2 2 1 1 1 2 | 28 1.9|
Pars Distalis, Cyst, Multiple | | 1 3.0|
Pars Distalis, Hyperplasia | 2 2 | 13 1.5|
Pars Intermedia, Angiectasis | | 6 2.2|
Pars Intermedia, Cyst | 2 1 1 | 6 1.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 50 |
Ultimobranchial Cyst | X | 3 1.0|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 | 37 1.0|
Follicle, Cyst | 1 | 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 12 |
Abscess | | 1 4.0|
Inflammation, Chronic | 1 | 4 1.3|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + M + | 48 |
Cyst | 2 | 2 2.0|
Periovarian Tissue, Cyst | 4 | 5 2.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 50 |
Hydrometra | 2 4 2 3 | 14 2.4|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Metaplasia, Squamous | 3 | 1 3.0|
Endometrium, Hyperplasia | 2 | 7 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 49 |
Lumbar, Infiltration Cellular, | | |
Histiocyte | 1 | 1 1.0|
Lumbar, Pigmentation | 1 | 1 1.0|
Mediastinal, Depletion Lymphoid | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4| | |
DAY ON TEST | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6| | |
| 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hemorrhage | 3 2 | 7 1.7|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
Mediastinal, Necrosis, Coagulative | | 1 4.0|
Mediastinal, Pigmentation | 2 | 2 2.0|
Pancreatic, Ectasia | 2 | 1 2.0|
Pancreatic, Hemorrhage | 2 | 2 1.5|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 2 | 2 2.0|
Pancreatic, Pigmentation | 2 2 | 3 2.0|
Renal, Hemorrhage | 2 3 1 | 3 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | 2 3 2 | 4 2.5|
Renal, Pigmentation | 2 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 46 |
Ectasia | 1 2 1 | 6 1.5|
Hemorrhage | 1 2 1 1 2 2 | 17 1.8|
Infiltration Cellular, Histiocyte | 1 | 2 1.0|
Pigmentation | 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 9 |
Ectasia | | 1 3.0|
Infiltration Cellular, Histiocyte | 1 | 7 1.3|
Necrosis, Coagulative | 4 | 1 4.0|
Pigmentation | 1 | 7 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 50 |
Depletion Lymphoid | | 9 2.6|
Hematopoietic Cell Proliferation | | 1 3.0|
Inflammation, Chronic, Granulomatous | | 1 2.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + | 9 |
Depletion Lymphoid | 4 3 | 7 3.0|
Necrosis, Coagulative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 22 |
Galactocele | | 1 3.0|
Hyperplasia | 2 1 2 | 13 1.8|
__________________________________________________________________________|____________|
Skin | + + | 11 |
Subcutaneous Tissue, Edema | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4| | |
DAY ON TEST | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6| | |
| 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 14 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 50 |
Hemorrhage | | 2 1.0|
Hydrocephalus | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 50 |
Hemorrhage | 1 1 | 4 1.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 18 1.1|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Pigmentation | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Artery, Mineralization | 1 1 | 14 1.0|
__________________________________________________________________________|____________|
Nose | + + | 10 |
Capillary, Submucosa, Thrombosis | 2 | 1 2.0|
Glands, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Cataract | | 1 2.0|
Retina, Degeneration | 3 | 2 3.0|
Sclera, Metaplasia, Osseous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 50 |
Congestion | | 1 2.0|
Nephropathy | 3 3 1 2 4 4 2 1 1 2 4 3 3 2 | 48 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 1| 7| 7| 6| 4| 7| 7| 6| 6| 1| 1| 6| 5| 6| 6| 7| 7| 7| 4| 4| | |
DAY ON TEST | 9| 2| 2| 8| 6| 3| 2| 8| 3| 9| 9| 3| 4| 6| 8| 2| 2| 3| 6| 6| | |
| 3| 3| 4| 8| 6| 1| 9| 6| 2| 3| 3| 7| 9| 0| 8| 3| 3| 1| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
4.0% HF | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Hyperplasia | | 1 1.0|
Transitional Epithelium, Hyperplasia | 1 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 50 |
Hemorrhage | | 1 4.0|
Inflammation, Acute | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|
| 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A +|
Parasite Metazoan | 1 1 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + M + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 1|
Clear Cell Focus | 1 1 2 1 |
Congestion | 2 |
Cytoplasmic Alteration | 2 2 |
Degeneration, Cystic | |
Degeneration | 1 |
Eosinophilic Focus | 1 2 1|
Fatty Change | 3 2 |
Fibrosis | |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal | 3 |
Inflammation, Chronic | 1 1 2 1 1|
Mixed Cell Focus | |
Necrosis, Coagulative | 3 2 |
Bile Duct, Hyperplasia | 2 2 1 1 1 2 2 3 2 1 3 1 1 2 2 1|
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | |
Necrosis, Coagulative | 3 |
Pigmentation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 1 1 1 1 1 3|
Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 1 1 2|
Pigmentation | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + M |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + M + + + + + + +|
Hyperplasia, Basal Cell | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|
| 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Muscularis, Mineralization | 2 |
Submucosa, Fibrosis | |
__________________________________________________________________________|
Tongue | + + M + + + + + + + + + + M + + +|
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 1 3 2 3 3 1 2 2 1 2 2 2 2 3|
Thrombosis | 3 |
Coronary Artery, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Atrophy | |
Congestion | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 1 1 2 |
Vacuolization Cytoplasmic | 2 1 2 1 1 2 1 2 3 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Hyperplasia | 3 2 1 3 1 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + M +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + A M + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 2 1 1 |
Pars Distalis, Hyperplasia | 1 2 2 2 1 1 2 |
Pars Intermedia, Cyst | 1 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 2 1 2 1 2 1 1 |
Follicle, Pigmentation | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|
| 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Adventitia, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + M + + + |
Cyst | |
Inflammation, Chronic | 2 2 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + M + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 4 2 1 2 3|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 3 3 3 2 2 2 2 2 3 2|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | 3 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 3 4 4 4 4 4 2 4 4 4 4 4 4 3 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Lumbar, Ectasia | |
Lumbar, Hemorrhage | |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Pigmentation | 2 |
Pancreatic, Ectasia | |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia, Plasma Cell | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 |
Pancreatic, Pigmentation | 2 1 |
Renal, Ectasia | 4 |
Renal, Hemorrhage | |
Renal, Hyperplasia, Plasma Cell | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + + + + + + + + + M + + + + +|
Angiectasis | 3 |
Ectasia | |
Hemorrhage | 3 2 4 3|
Hyperplasia, Plasma Cell | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + M + M + M + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|
| 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | 2 2 2 1 |
Pigmentation | 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 3 4 3 2 3 |
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | |
Infarct | 2 2 |
Necrosis, Coagulative | |
Pigmentation | |
__________________________________________________________________________|
Thymus | + M + + M + + + M + M |
Depletion Lymphoid | 2 3 3 3 |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + M + +|
Galactocele | |
Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + +|
Acanthosis | 2 |
Cyst Epithelial Inclusion | X X|
Hyperkeratosis | 4 |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Cerebellum, Infarct | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 |
Necrosis, Coagulative | |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 6| 7| 2| 5| 7| 4| 5| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 1| 7| 7| 6| 4| 7|
DAY ON TEST | 8| 3| 2| 2| 7| 2| 6| 6| 8| 8| 2| 2| 0| 7| 5| 2| 2| 2| 2| 8| 2| 2| 8| 6| 2|
| 9| 6| 9| 6| 3| 9| 5| 2| 9| 9| 9| 8| 4| 9| 8| 9| 9| 4| 4| 9| 4| 1| 2| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Glands, Inflammation, Acute | 1 1 1 |
Lumen, Inflammation, Acute | 1 2 |
Nasopharyngeal Duct, Inflammation, | |
Chronic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M |
Cornea, Fibrosis | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Nephropathy | 2 4 2 4 3 4 4 2 3 1 2 3 3 3 2 2 2 3|
Proximal Convoluted Renal Tubule, | |
Epithelium, Pigmentation | 3 |
Renal Tubule, Hyperplasia | 2|
Transitional Epithelium, Hyperplasia | 2 1 2 1 1 2|
Transitional Epithelium, | |
Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|
DAY ON TEST | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|
| 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Basophilic Focus | 1 1 1 1 |
Clear Cell Focus | 1 1 1 |
Congestion | |
Cytoplasmic Alteration | |
Degeneration, Cystic | 1 1 1 1 1 1 |
Degeneration | 1 1 |
Eosinophilic Focus | 2 1 1 1 |
Fatty Change | 1 |
Fibrosis | 1 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | X |
Necrosis, Coagulative | 2 2 1 |
Bile Duct, Hyperplasia | 1 2 1 3 1 1 1 3 1 2 1 1 2 2 1 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 3 |
Necrosis, Coagulative | |
Pigmentation | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Atrophy | 1 1 1 2 4 3 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1 |
Pigmentation | 3 |
Duct, Dilatation | 1 |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
Hyperplasia, Basal Cell | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|
DAY ON TEST | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|
| 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 |
Muscularis, Mineralization | |
Submucosa, Fibrosis | 3 |
__________________________________________________________________________|
Tongue | + + + + + + + + M + + + + + + + |
Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 3 2 2 2 2 3 3 2 3 |
Thrombosis | 3 3 |
Coronary Artery, Inflammation, | |
Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + |
Angiectasis | 1 1 2 2 1 |
Atrophy | 3 |
Congestion | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + |
Angiectasis | 2 1 |
Atrophy | 3 |
Hyperplasia | 1 1 2 1 2 2 2 2 2 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M |
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Cyst | 2 1 |
Pars Distalis, Hyperplasia | 2 1 1 1 2 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 1 1 1 1 1 |
Follicle, Pigmentation | 1 |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|
DAY ON TEST | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|
| 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Adventitia, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + |
Cyst | 4 |
Inflammation, Chronic | 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 2 2 2 1 2 1 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + |
Atrophy | 2 2 2 2 2 2 3 2 2 3 2 2 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + |
Necrosis, Coagulative | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 4 2 3 3 4 4 4 3 4 4 4 4 4 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + + + + + + + + |
Lumbar, Ectasia | 2 |
Lumbar, Hemorrhage | |
Mediastinal, Hemorrhage | 2 2 2 |
Mediastinal, Pigmentation | |
Pancreatic, Ectasia | |
Pancreatic, Hemorrhage | 4 1 |
Pancreatic, Hyperplasia, Plasma Cell | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Pigmentation | 2 |
Renal, Ectasia | |
Renal, Hemorrhage | 3 |
Renal, Hyperplasia, Plasma Cell | 2 |
Renal, Pigmentation | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + |
Angiectasis | |
Ectasia | 2 2 |
Hemorrhage | 3 2 3 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|
DAY ON TEST | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|
| 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Histiocyte | 2 1 2 2 |
Pigmentation | 2 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Congestion | |
Depletion Lymphoid | 3 3 |
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 3 |
Infarct | |
Necrosis, Coagulative | 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + |
Depletion Lymphoid | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + |
Galactocele | 2 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + |
Acanthosis | |
Cyst Epithelial Inclusion | |
Hyperkeratosis | |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
Hemorrhage | |
Cerebellum, Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 2 1 |
Necrosis, Coagulative | 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 1| 7| 7| 4| 1| 7| 6| 4| 1| 4| 7| 7| 7| 7| 6| 1| 7| 6| 6| 4|
DAY ON TEST | 2| 2| 1| 9| 6| 8| 2| 2| 6| 9| 2| 5| 6| 9| 6| 2| 2| 2| 2| 5| 9| 2| 7| 6| 6|
| 7| 7| 7| 0| 5| 9| 7| 4| 5| 1| 9| 6| 5| 1| 3| 9| 9| 4| 4| 4| 1| 7| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Glands, Inflammation, Acute | 1 1 2 1 1 1 |
Lumen, Inflammation, Acute | |
Nasopharyngeal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Fibrosis | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Congestion | |
Cyst | 2 3 |
Nephropathy | 2 3 4 2 4 4 4 3 3 3 2 2 2 3 3 2 |
Proximal Convoluted Renal Tubule, | |
Epithelium, Pigmentation | 3 2 3 |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | 2 1 2 1 1 1 |
Transitional Epithelium, | |
Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4| | |
DAY ON TEST | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6| | |
| 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 49 |
Parasite Metazoan | 1 | 4 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 49 |
Parasite Metazoan | 1 2 2 1 | 9 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 49 |
Parasite Metazoan | 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 50 |
Basophilic Focus | 1 X 1 1 1 1 1 1 | 16 1.0|
Clear Cell Focus | | 7 1.1|
Congestion | | 1 2.0|
Cytoplasmic Alteration | | 2 2.0|
Degeneration, Cystic | | 6 1.0|
Degeneration | 1 | 4 1.0|
Eosinophilic Focus | 2 3 | 9 1.6|
Fatty Change | 3 3 | 5 2.4|
Fibrosis | | 2 1.5|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 2 |
Hyperplasia, Focal | | 1 3.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 | 24 1.0|
Mixed Cell Focus | 2 2 | 3 2.0|
Necrosis, Coagulative | 1 1 | 7 1.7|
Bile Duct, Hyperplasia | 1 2 1 3 2 2 2 2 1 2 2 1 2 1 | 46 1.7|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Inflammation, Chronic | 1 | 2 2.0|
Necrosis, Coagulative | | 1 3.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 50 |
Atrophy | 2 1 2 2 1 2 1 2 | 23 1.7|
Inflammation, Chronic | 1 1 1 1 2 1 1 2 | 32 1.2|
Pigmentation | | 1 3.0|
Duct, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4| | |
DAY ON TEST | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6| | |
| 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 49 |
Hyperplasia, Basal Cell | 1 | 3 1.3|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 3.0|
Muscularis, Mineralization | | 1 2.0|
Submucosa, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 45 |
Metaplasia, Osseous | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 50 |
Cardiomyopathy | 2 2 2 2 2 3 2 2 3 2 3 3 2 2 | 48 2.1|
Thrombosis | 4 4 4 | 6 3.5|
Coronary Artery, Inflammation, | | |
Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 50 |
Angiectasis | | 6 1.3|
Atrophy | | 1 3.0|
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 1 1 1 1 1 | 10 1.2|
Vacuolization Cytoplasmic | 1 1 2 1 1 1 2 1 1 2 1 1 | 26 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 50 |
Angiectasis | | 2 1.5|
Atrophy | | 1 3.0|
Hyperplasia | 1 2 2 1 2 1 1 | 22 1.7|
Necrosis, Coagulative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + | 47 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M + + + + + + M M + + | 43 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4| | |
DAY ON TEST | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6| | |
| 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Angiectasis | | 2 1.5|
Pars Distalis, Cyst | X X | 7 1.4|
Pars Distalis, Hyperplasia | 2 1 1 1 1 | 18 1.4|
Pars Intermedia, Cyst | 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 50 |
Inflammation, Acute | 3 | 1 3.0|
Ultimobranchial Cyst | | 2 1.0|
C-Cell, Hyperplasia | 1 1 1 1 | 17 1.2|
Follicle, Pigmentation | | 1 1.0|
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
Adventitia, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 13 |
Cyst | | 1 4.0|
Inflammation, Chronic | 2 3 2 3 3 | 12 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic Active | 2 1 2 1 1 2 1 3 2 2 | 25 1.7|
Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 50 |
Atrophy | 2 3 3 3 2 2 2 2 3 3 | 36 2.4|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 50 |
Necrosis, Coagulative | | 1 3.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 | 34 1.0|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 3 3 4 4 4 3 4 3 | 44 3.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 49 |
Lumbar, Ectasia | | 1 2.0|
Lumbar, Hemorrhage | 3 | 1 3.0|
Mediastinal, Hemorrhage | 2 3 | 6 2.2|
Mediastinal, Pigmentation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4| | |
DAY ON TEST | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6| | |
| 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Ectasia | 2 | 1 2.0|
Pancreatic, Hemorrhage | 3 | 3 2.7|
Pancreatic, Hyperplasia, Plasma Cell | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 3 2.0|
Pancreatic, Pigmentation | | 3 1.7|
Renal, Ectasia | | 1 4.0|
Renal, Hemorrhage | 1 2 1 1 | 5 1.6|
Renal, Hyperplasia, Plasma Cell | | 1 2.0|
Renal, Pigmentation | 2 1 2 | 6 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 46 |
Angiectasis | | 1 3.0|
Ectasia | 2 | 3 2.0|
Hemorrhage | 2 3 1 3 | 12 2.7|
Hyperplasia, Plasma Cell | 4 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + | 22 |
Hemorrhage | 3 1 | 3 1.7|
Hyperplasia, Plasma Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 2 | 11 1.8|
Pigmentation | 1 1 | 9 1.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 50 |
Congestion | 4 | 1 4.0|
Depletion Lymphoid | 3 3 | 9 3.0|
Fibrosis | 4 3 | 6 2.7|
Hematopoietic Cell Proliferation | | 1 3.0|
Infarct | | 2 2.0|
Necrosis, Coagulative | | 1 2.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M | 14 |
Depletion Lymphoid | 3 3 3 | 7 2.9|
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + | 13 |
Galactocele | | 1 2.0|
Hyperplasia | 2 2 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 20 |
Acanthosis | | 1 2.0|
Cyst Epithelial Inclusion | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4| | |
DAY ON TEST | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6| | |
| 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | | 1 4.0|
Subcutaneous Tissue, Abscess | 4 | 1 4.0|
Subcutaneous Tissue, Edema | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 10 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 50 |
Hemorrhage | 1 | 2 2.5|
Cerebellum, Infarct | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 50 |
Hemorrhage | 1 | 4 1.3|
Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 1 1 1 1 1 1 1 | 31 1.1|
Necrosis, Coagulative | | 1 1.0|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 | 34 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 44 |
Glands, Inflammation, Acute | 1 1 | 11 1.1|
Lumen, Inflammation, Acute | | 2 1.5|
Nasopharyngeal Duct, Inflammation, | | |
Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | I + + I | 2 |
Cornea, Fibrosis | 3 | 1 3.0|
Retina, Degeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 50 |
Congestion | 2 1 | 2 1.5|
Cyst | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 7| 6| 5| 4| 7| 7| 7| 7| 5| 1| 1| 7| 6| 4| | |
DAY ON TEST | 1| 8| 5| 4| 6| 2| 2| 3| 7| 6| 2| 2| 2| 2| 1| 8| 8| 2| 2| 6| | |
| 7| 9| 4| 0| 5| 9| 9| 6| 5| 5| 9| 9| 9| 0| 9| 9| 9| 4| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 3 3 2 3 4 2 2 3 3 3 3 2 4 2 | 48 2.8|
Proximal Convoluted Renal Tubule, | | |
Epithelium, Pigmentation | 2 | 5 2.6|
Renal Tubule, Hyperplasia | | 1 2.0|
Transitional Epithelium, Hyperplasia | 1 2 | 14 1.4|
Transitional Epithelium, | | |
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 50 |
Calculus Micro Observation Only | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|
DAY ON TEST | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|
| 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + M + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + M + |
Necrosis, Coagulative | |
Epithelium, Pigmentation | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + M + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + |
Angiectasis | |
Basophilic Focus | 1 1 1 1 1 1 |
Clear Cell Focus | 1 1 2 1 |
Cytoplasmic Alteration | 1 |
Degeneration, Cystic | 1 1 |
Degeneration | 1 1 |
Eosinophilic Focus | |
Fatty Change | 1 2 3 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 2 1 3 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 1 1 1 1 1 1 1 2 3 2 1 2 1 |
Centrilobular, Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + |
Fibrosis | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + |
Atrophy | 1 1 1 1 1 1 1 1 |
Cytoplasmic Alteration | 2 |
Ectopic Liver | |
Hyperplasia | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 |
Artery, Fibrosis | |
Artery, Inflammation, Chronic Active,| |
Necrotizing | |
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|
DAY ON TEST | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|
| 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + |
Acanthosis | 1 |
Hyperkeratosis | 1 |
Hyperplasia, Basal Cell | 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + M + + |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Cardiomyopathy | 2 2 2 3 1 3 |
Cytomegaly | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
Angiectasis | |
Congestion | |
Hyperplasia | |
Necrosis, Coagulative | 1 |
Vacuolization Cytoplasmic | 1 1 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + M + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + |
Autolysis | 2 |
Pars Distalis, Angiectasis | |
Pars Distalis, Autolysis | |
Pars Distalis, Cyst | 1 2 |
Pars Distalis, Hyperplasia | 3 2 1 2 1 1 |
Pars Distalis, Necrosis | 4 |
Pars Distalis, Pigmentation | 2 1 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|
DAY ON TEST | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|
| 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Angiectasis | 4 3 |
Pars Intermedia, Cyst | 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
Congestion | 1 |
C-Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Abscess | 4 |
Inflammation, Chronic | 2 2 2 3 2 2 2 3 3 |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + |
Hemorrhage | 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 4 3 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + |
Atrophy | 3 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + |
Infarct | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 3 2 2 4 4 4 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Angiectasis | |
Inguinal, Ectasia | 4 |
Lumbar, Ectasia | 2 4 |
Lumbar, Hemorrhage | |
Lumbar, Infiltration Cellular, | |
Histiocyte | |
Lumbar, Inflammation, Acute | 2 |
Lumbar, Pigmentation | |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Pigmentation | 3 |
Pancreatic, Hemorrhage | 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|
DAY ON TEST | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|
| 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Pigmentation | 1 |
Renal, Ectasia | 3 4 |
Renal, Fibrosis | 2 |
Renal, Hemorrhage | 1 |
Renal, Infiltration Cellular, | |
Histiocyte | 2 1 |
Renal, Pigmentation | 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
Congestion | 1 |
Ectasia | |
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 2 1 1 |
Pigmentation | 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + |
Congestion | |
Depletion Lymphoid | 2 3 4 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 |
__________________________________________________________________________|
Thymus | + + M + M + |
Depletion Lymphoid | 3 1 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + |
Abscess | |
Galactocele | 2 |
Hyperplasia | 2 2 2 2 1 |
Pigmentation | 1 2 |
__________________________________________________________________________|
Skin | + + + + + + |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Hindlimb, Mineralization | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|
DAY ON TEST | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|
| 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Congestion | |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + |
Foreign Body | |
Metaplasia, Squamous | |
Glands, Inflammation, Acute | 1 1 1 2 |
Lumen, Hemorrhage | |
Lumen, Inflammation, Acute | |
Nasopharyngeal Duct, Inflammation, | |
Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Fibrosis | |
Cornea, Inflammation, Chronic | |
Sclera, Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + |
Autolysis | |
Cyst | 1 |
Hemorrhage | |
Hydronephrosis | |
Nephropathy | 3 3 2 3 2 3 4 2 2 2 2 3 3 4 2 |
Artery, Inflammation, Chronic Active,| |
Necrotizing | 3 |
Interstitial Tissue, Proximal | |
Convoluted Renal Tubule, | |
Inflammation, Acute | |
Proximal Convoluted Renal Tubule, | |
Mineralization | |
Proximal Convoluted Renal Tubule, | |
Necrosis | |
Proximal Convoluted Renal Tubule, | |
Epithelium, Pigmentation | 2 |
Renal Tubule, Hyperplasia, Cystic | |
Renal Tubule, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 4| 4| 1| 1| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 6| 5| 5| 4| 1| 7| 6| 5| 1| 1|
DAY ON TEST | 2| 6| 6| 8| 8| 3| 2| 2| 5| 6| 3| 9| 8| 4| 6| 1| 9| 5| 6| 8| 2| 1| 6| 8| 8|
| 7| 5| 3| 9| 9| 0| 9| 7| 4| 5| 0| 5| 5| 3| 5| 8| 9| 6| 5| 9| 9| 8| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, Hyperplasia | 1 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Submucosa, Hemorrhage | |
Subserosa, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|
DAY ON TEST | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|
| 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% LM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + A + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + |
Necrosis, Coagulative | 2 |
Epithelium, Pigmentation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + A + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Basophilic Focus | 1 1 1 1 1 1 1 |
Clear Cell Focus | 2 2 3 |
Cytoplasmic Alteration | |
Degeneration, Cystic | 2 2 1 |
Degeneration | |
Eosinophilic Focus | 1 1 1 2 |
Fatty Change | 2 2 2 |
Hemorrhage | 1 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | 2 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | 2 2 |
Necrosis, Coagulative | 1 2 1 |
Thrombosis | 3 |
Bile Duct, Hyperplasia | 2 1 1 1 1 2 1 2 1 3 1 2 1 1 3 2 2 1 3 |
Centrilobular, Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Atrophy | 1 1 2 1 2 1 1 1 1 1 1 2 |
Cytoplasmic Alteration | |
Ectopic Liver | |
Hyperplasia | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 |
Artery, Fibrosis | 3 4 |
Artery, Inflammation, Chronic Active,| |
Necrotizing | 4 |
Duct, Dilatation | 1 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|
DAY ON TEST | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|
| 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% LM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Perivascular, Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + M + + + + + + + + + + + + + + + |
Acanthosis | 2 2 1 |
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 2 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + M |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 1 1 |
Cytomegaly | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
Angiectasis | |
Congestion | 2 1 |
Hyperplasia | |
Necrosis, Coagulative | 1 |
Vacuolization Cytoplasmic | 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + M + + + |
Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Pituitary Gland | + I + + + + + + + + + + + + + + + + + |
Autolysis | |
Pars Distalis, Angiectasis | |
Pars Distalis, Autolysis | 3 |
Pars Distalis, Cyst | 1 1 2 |
Pars Distalis, Hyperplasia | 2 1 2 1 2 1 1 2 2 |
Pars Distalis, Necrosis | |
Pars Distalis, Pigmentation | 2 1 |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|
DAY ON TEST | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|
| 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% LM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | 1 1 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
Congestion | |
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + |
Abscess | 4 2 4 |
Inflammation, Chronic | 2 2 2 2 2 2 2 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Prostate | + + + + + + |
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Chronic Active | 4 3 3 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
Atrophy | 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + |
Infarct | 4 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 2 1 4 4 1 3 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Angiectasis | |
Inguinal, Ectasia | |
Lumbar, Ectasia | 2 |
Lumbar, Hemorrhage | |
Lumbar, Infiltration Cellular, | |
Histiocyte | 1 |
Lumbar, Inflammation, Acute | |
Lumbar, Pigmentation | |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | 4 |
Mediastinal, Pigmentation | 1 1 1 |
Pancreatic, Hemorrhage | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|
DAY ON TEST | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|
| 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% LM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Pigmentation | |
Renal, Ectasia | |
Renal, Fibrosis | |
Renal, Hemorrhage | 1 |
Renal, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Pigmentation | 2 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Congestion | |
Ectasia | 4 |
Hemorrhage | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 2 1 1 |
Pigmentation | 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + |
Congestion | 3 3 |
Depletion Lymphoid | 3 3 3 3 2 2 |
Fibrosis | 4 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + |
Depletion Lymphoid | 4 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M M |
Abscess | 4 |
Galactocele | |
Hyperplasia | 3 2 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Hindlimb, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Hemorrhage | 1 2 |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|
DAY ON TEST | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|
| 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% LM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Congestion | 3 |
Hemorrhage | 1 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Mineralization | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Foreign Body | |
Metaplasia, Squamous | 3 |
Glands, Inflammation, Acute | 1 1 1 |
Lumen, Hemorrhage | 3 |
Lumen, Inflammation, Acute | 2 |
Nasopharyngeal Duct, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + |
Cornea, Fibrosis | 3 |
Cornea, Inflammation, Chronic | |
Sclera, Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Cyst | 1 1 2 1 |
Hemorrhage | 2 |
Hydronephrosis | |
Nephropathy | 4 3 4 3 2 2 2 3 4 2 1 2 2 3 3 1 4 4 2 |
Artery, Inflammation, Chronic Active,| |
Necrotizing | |
Interstitial Tissue, Proximal | |
Convoluted Renal Tubule, | |
Inflammation, Acute | 2 |
Proximal Convoluted Renal Tubule, | |
Mineralization | |
Proximal Convoluted Renal Tubule, | |
Necrosis | |
Proximal Convoluted Renal Tubule, | |
Epithelium, Pigmentation | 2 |
Renal Tubule, Hyperplasia, Cystic | 2 |
Renal Tubule, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 1| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 4| 7| 7| 1| 5| 1| 7| 7| 1| 5| 4|
DAY ON TEST | 3| 9| 3| 2| 6| 2| 2| 2| 2| 2| 2| 0| 2| 4| 5| 3| 2| 9| 0| 9| 3| 3| 9| 8| 6|
| 0| 1| 0| 9| 3| 9| 9| 7| 7| 4| 8| 4| 0| 6| 8| 0| 3| 1| 9| 1| 0| 0| 1| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.1% LM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 |
Submucosa, Hemorrhage | 1 |
Subserosa, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6| | |
| 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 12 |
__________________________________________________________________________|____________|
Intestine Large | + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 11 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 12 |
Parasite Metazoan | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + | 47 |
Necrosis, Coagulative | | 1 2.0|
Epithelium, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + | 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | 1 1 1 1 | 17 1.0|
Clear Cell Focus | 1 3 X | 10 1.8|
Cytoplasmic Alteration | 2 2 | 3 1.7|
Degeneration, Cystic | | 5 1.4|
Degeneration | | 2 1.0|
Eosinophilic Focus | 2 | 5 1.4|
Fatty Change | 1 1 3 3 2 | 12 1.9|
Hemorrhage | 1 2 | 4 1.5|
Hepatodiaphragmatic Nodule | | 1 |
Hyperplasia, Focal | 3 | 2 2.5|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 30 1.0|
Mixed Cell Focus | 2 1 | 4 1.8|
Necrosis, Coagulative | 2 | 8 1.6|
Thrombosis | | 1 3.0|
Bile Duct, Hyperplasia | 1 1 1 2 1 1 2 1 1 2 1 1 1 1 | 48 1.5|
Centrilobular, Necrosis, Coagulative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Fibrosis | 4 | 1 4.0|
Necrosis, Coagulative | 4 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + | 50 |
Atrophy | 1 1 2 1 1 1 | 26 1.2|
Cytoplasmic Alteration | 1 | 2 1.5|
Ectopic Liver | X | 1 |
Hyperplasia | 2 2 1 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6| | |
| 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 28 1.0|
Artery, Fibrosis | 3 | 3 3.3|
Artery, Inflammation, Chronic Active,| | |
Necrotizing | | 1 4.0|
Duct, Dilatation | | 1 1.0|
Perivascular, Inflammation, Chronic | 2 | 3 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 14 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + | 49 |
Acanthosis | 1 1 | 6 1.3|
Hyperkeratosis | 2 | 3 1.7|
Hyperplasia, Basal Cell | 1 1 1 1 1 1 | 9 1.1|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 1.0|
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + + | 48 |
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 18 |
Cardiomyopathy | 3 | 14 2.0|
Cytomegaly | 4 | 1 4.0|
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 18 |
Angiectasis | 2 | 1 2.0|
Congestion | 2 | 3 1.7|
Hyperplasia | 2 2 | 2 2.0|
Necrosis, Coagulative | | 2 1.0|
Vacuolization Cytoplasmic | 2 3 1 2 | 12 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 18 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 15 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6| | |
| 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + | 45 |
Hyperplasia | 2 2 | 6 1.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + | 49 |
Autolysis | | 1 2.0|
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Autolysis | | 1 3.0|
Pars Distalis, Cyst | 1 | 6 1.3|
Pars Distalis, Hyperplasia | 2 2 1 4 2 1 2 2 1 | 24 1.7|
Pars Distalis, Necrosis | | 1 4.0|
Pars Distalis, Pigmentation | 1 | 5 1.4|
Pars Intermedia, Angiectasis | | 2 3.5|
Pars Intermedia, Cyst | 1 1 | 10 1.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 17 |
Congestion | | 1 1.0|
C-Cell, Hyperplasia | | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + | 13 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 22 |
Abscess | 3 | 5 3.4|
Inflammation, Chronic | 3 2 3 | 19 2.3|
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + | 14 |
Hemorrhage | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 1 | 9 2.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 22 |
Atrophy | 3 3 3 2 | 9 2.9|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + | 46 |
Infarct | | 1 4.0|
Interstitial Cell, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 | 35 1.1|
Seminiferous Tubule, Atrophy | 4 4 4 2 4 3 3 4 3 4 3 3 4 4 4 4 | 44 3.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6| | |
| 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 29 |
Angiectasis | 1 | 1 1.0|
Inguinal, Ectasia | | 1 4.0|
Lumbar, Ectasia | | 3 2.7|
Lumbar, Hemorrhage | 3 | 1 3.0|
Lumbar, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Lumbar, Inflammation, Acute | | 1 2.0|
Lumbar, Pigmentation | 2 | 1 2.0|
Mediastinal, Ectasia | 1 3 | 2 2.0|
Mediastinal, Hemorrhage | 1 2 | 4 2.3|
Mediastinal, Pigmentation | 1 | 5 1.4|
Pancreatic, Hemorrhage | 2 | 2 1.5|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 2 | 5 2.0|
Pancreatic, Pigmentation | 1 | 2 1.0|
Renal, Ectasia | | 2 3.5|
Renal, Fibrosis | | 1 2.0|
Renal, Hemorrhage | 3 2 | 4 1.8|
Renal, Infiltration Cellular, | | |
Histiocyte | 2 | 4 1.8|
Renal, Pigmentation | 2 2 | 6 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 18 |
Congestion | | 1 1.0|
Ectasia | | 1 4.0|
Hemorrhage | 1 3 | 4 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 14 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 1 | 10 1.2|
Pigmentation | 1 | 9 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 25 |
Congestion | | 2 3.0|
Depletion Lymphoid | 4 3 1 3 4 | 14 2.9|
Fibrosis | 3 2 1 | 5 2.4|
Hematopoietic Cell Proliferation | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | M + | 11 |
Depletion Lymphoid | | 5 2.6|
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6| | |
| 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 10 |
Abscess | | 1 4.0|
Galactocele | | 1 2.0|
Hyperplasia | 1 | 9 1.8|
Pigmentation | | 3 1.3|
__________________________________________________________________________|____________|
Skin | + + + + | 18 |
Cyst Epithelial Inclusion | X | 3 |
Hyperkeratosis | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 12 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Hindlimb, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 15 |
Hemorrhage | | 2 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 28 |
Congestion | | 1 3.0|
Hemorrhage | 2 1 1 | 6 1.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | 18 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 1 | 4 1.3|
Artery, Mineralization | 1 1 1 1 1 1 | 13 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 48 |
Foreign Body | 1 | 1 1.0|
Metaplasia, Squamous | | 1 3.0|
Glands, Inflammation, Acute | 1 1 1 1 | 11 1.1|
Lumen, Hemorrhage | | 1 3.0|
Lumen, Inflammation, Acute | 1 1 | 3 1.3|
Nasopharyngeal Duct, Inflammation, | | |
Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 1| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 2| 7| 6| 2| 9| 3| 2| 2| 2| 2| 7| 7| 6| 3| 2| 2| 1| 6| | |
| 0| 9| 0| 2| 3| 1| 1| 0| 7| 4| 9| 7| 8| 1| 3| 0| 9| 9| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.1% LM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + I | 9 |
Cornea, Fibrosis | | 1 3.0|
Cornea, Inflammation, Chronic | 2 | 1 2.0|
Sclera, Metaplasia, Osseous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + | 50 |
Autolysis | 2 | 2 2.0|
Cyst | 2 | 6 1.3|
Hemorrhage | | 1 2.0|
Hydronephrosis | 2 | 1 2.0|
Nephropathy | 4 3 3 2 3 3 4 2 3 2 3 2 2 3 3 3 | 50 2.7|
Artery, Inflammation, Chronic Active,| | |
Necrotizing | | 1 3.0|
Interstitial Tissue, Proximal | | |
Convoluted Renal Tubule, | | |
Inflammation, Acute | | 1 2.0|
Proximal Convoluted Renal Tubule, | | |
Mineralization | 1 | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Necrosis | 2 | 1 2.0|
Proximal Convoluted Renal Tubule, | | |
Epithelium, Pigmentation | | 2 2.0|
Renal Tubule, Hyperplasia, Cystic | | 1 2.0|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | 1 1 2 | 9 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic | 1 | 2 1.0|
Submucosa, Hemorrhage | | 1 1.0|
Subserosa, Mineralization | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|
DAY ON TEST | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|
| 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M |
__________________________________________________________________________|
Intestine Large | + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + |
__________________________________________________________________________|
Intestine Large, Colon | + + |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + +|
Epithelium, Pigmentation | 1 1 2 1 2 1 1 |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + +|
Autolysis | 3 |
Epithelium, Pigmentation | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 2 1 1 1 1 1|
Clear Cell Focus | 1 1 1 1 |
Cytoplasmic Alteration | |
Degeneration, Cystic | 2 1 |
Degeneration | |
Eosinophilic Focus | 2 1 3 |
Fatty Change | |
Hemorrhage | |
Inflammation, Chronic | 1 1 1 1 1 1 1 |
Mixed Cell Focus | 2 |
Mixed Cell Focus, Multiple | |
Necrosis, Coagulative | 1 1 1 1 |
Thrombosis | X |
Bile Duct, Hyperplasia | 1 1 1 3 1 2 1 3 1 1 2 1 2 1|
Centrilobular, Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | |
Mineralization | |
Necrosis, Coagulative | |
Pigmentation | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + +|
Atrophy | 2 1 1 1 2 1|
Cyst | 4 |
Fibrosis | 2 2 |
Hyperplasia | 1 2|
Inflammation, Chronic | 2 1 2 1 1 3 2|
Necrosis, Coagulative | 3 |
Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|
DAY ON TEST | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|
| 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Thrombosis | 2 |
Artery, Inflammation, Chronic Active,| |
Necrotizing | 4 |
Serosa, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + |
Parotid Gland, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + +|
Acanthosis | 2|
Hyperkeratosis | 2|
Hyperplasia, Basal Cell | 1 1 2|
Mineralization | 1 |
Ulcer | |
Muscularis, Pigmentation | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis, Coagulative | |
Epithelium, Pigmentation | |
Mucosa, Mineralization | 3 4 |
Muscularis, Mineralization | 3 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + +|
Artery, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + +|
Cardiomyopathy | 2 2 3|
Metaplasia, Osseous | 1|
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + |
Angiectasis | |
Hemorrhage | |
Hyperplasia | |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + |
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|
DAY ON TEST | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|
| 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 3 1 1 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Autolysis | |
Pars Distalis, Congestion | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 1 2 1 1 1 1 3|
Pars Distalis, Pigmentation | |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Crystals | |
Pars Intermedia, Cyst | 1 1 1 |
Pars Intermedia, Ectopic Tissue | |
Pars Intermedia, Hyperplasia | |
Pars Nervosa, Ectopic Tissue | |
Pars Nervosa, Hyperplasia | |
Rathke's Cleft, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + |
C-Cell, Hyperplasia | 1 1 |
Follicle, Pigmentation | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + |
__________________________________________________________________________|
Preputial Gland | + + + + |
Abscess | 3 |
Inflammation, Chronic | 3 2 2 |
__________________________________________________________________________|
Prostate | + + |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + |
Atrophy | 3 2 1 2 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 2 2 2 1 1 1 2 1 1 1|
Seminiferous Tubule, Atrophy | 2 3 2 4 4 3 4 4 4 4 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Artery, Pancreatic, Thrombosis | |
Lumbar, Hemorrhage | |
Lumbar, Hyperplasia, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|
DAY ON TEST | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|
| 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Ectasia | 2 |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 |
Mediastinal, Pigmentation | 1 |
Pancreatic, Hemorrhage | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 |
Pancreatic, Pigmentation | 2 |
Renal, Ectasia | 3 |
Renal, Hemorrhage | 3 4 |
Renal, Hyperplasia, Lymphoid | |
Renal, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + |
Ectasia | 2 |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Ectasia | 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 1 1 1 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + |
Congestion | 4 |
Depletion Lymphoid | 2 2 2 3 |
Fibrosis | 3 3 3 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 1 |
Pigmentation | |
Thrombosis | 4 |
__________________________________________________________________________|
Thymus | + + |
Congestion | |
Depletion Lymphoid | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + |
Hyperplasia | 1 2 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Skin | + + + + +|
Acanthosis | |
Fibrosis | 2 |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|
DAY ON TEST | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|
| 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
Cerebrum, Degeneration, Focal | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Congestion | |
Edema | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Mineralization | 1 1 |
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + |
Metaplasia, Squamous | |
Glands, Inflammation, Acute | 1 1 |
Lumen, Inflammation, Acute | 1 |
Mucosa, Congestion | |
__________________________________________________________________________|
Trachea | + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + I |
Artery, Mineralization | 1 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | |
Hydronephrosis | |
Nephropathy | 3 4 2 3 3 4 2 3 2 2 2 4 2 4|
Collecting Tubule, Mineralization | 3 |
Proximal Convoluted Renal Tubule, | |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 6| 5| 1| 1| 5| 4| 4| 1| 1| 7| 7| 6| 4| 1| 7| 7| 7| 6| 4| 1| 7| 1| 6| 7|
DAY ON TEST | 2| 8| 5| 8| 8| 5| 6| 6| 8| 8| 2| 2| 8| 6| 8| 2| 2| 2| 7| 6| 9| 2| 9| 7| 2|
| 7| 7| 5| 9| 9| 5| 3| 3| 9| 9| 8| 7| 0| 3| 9| 9| 4| 4| 4| 5| 1| 8| 1| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 3 3 |
Proximal Convoluted Renal Tubule, | |
Epithelium, Pigmentation | |
Renal Tubule, Hyperplasia, Cystic | |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | 2 1 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Artery, Mineralization | |
Subserosa, Mineralization | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|
| 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Intestine Large | + + A + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + |
__________________________________________________________________________|
Intestine Large, Colon | + A + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + |
Epithelium, Pigmentation | 2 2 1 1 |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | M + + M + + M + + + A M + + + + + + + + |
Autolysis | |
Epithelium, Pigmentation | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Basophilic Focus | 2 1 1 1 1 1 |
Clear Cell Focus | |
Cytoplasmic Alteration | |
Degeneration, Cystic | 1 1 1 1 1 |
Degeneration | 1 |
Eosinophilic Focus | 1 1 1 |
Fatty Change | 1 3 3 |
Hemorrhage | 3 3 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | 1 3 |
Mixed Cell Focus, Multiple | |
Necrosis, Coagulative | 2 2 2 3 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 2 1 1 3 1 2 1 1 |
Centrilobular, Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + |
Fibrosis | 2 |
Mineralization | 1 |
Necrosis, Coagulative | 3 |
Pigmentation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Atrophy | 2 1 1 2 1 2 1 1 1 1 1 |
Cyst | |
Fibrosis | |
Hyperplasia | 2 |
Inflammation, Chronic | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Necrosis, Coagulative | |
Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|
| 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Thrombosis | |
Artery, Inflammation, Chronic Active,| |
Necrotizing | 4 |
Serosa, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + |
Parotid Gland, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | 2 1 1 1 |
Mineralization | 2 |
Ulcer | |
Muscularis, Pigmentation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 1 |
Necrosis, Coagulative | 1 |
Epithelium, Pigmentation | 1 |
Mucosa, Mineralization | |
Muscularis, Mineralization | |
__________________________________________________________________________|
Tongue | + M + + + + + + + + + + + + + + + + + + |
Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + |
Cardiomyopathy | 3 2 3 3 2 2 |
Metaplasia, Osseous | |
Thrombosis | 4 4 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
Angiectasis | 2 2 |
Hemorrhage | |
Hyperplasia | |
Necrosis, Coagulative | 1 |
Vacuolization Cytoplasmic | 2 1 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M + + + + + + + + + + + + I |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|
| 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Autolysis | 3 |
Pars Distalis, Congestion | 2 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 3 1 |
Pars Distalis, Pigmentation | |
Pars Intermedia, Angiectasis | 3 3 |
Pars Intermedia, Crystals | 4 |
Pars Intermedia, Cyst | 1 1 3 1 3 3 1 |
Pars Intermedia, Ectopic Tissue | |
Pars Intermedia, Hyperplasia | |
Pars Nervosa, Ectopic Tissue | |
Pars Nervosa, Hyperplasia | 2 |
Rathke's Cleft, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
C-Cell, Hyperplasia | 1 |
Follicle, Pigmentation | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Abscess | 4 |
Inflammation, Chronic | 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + |
Inflammation, Chronic Active | 4 1 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + |
Atrophy | 2 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + |
Interstitial Cell, Hyperplasia | 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 3 3 4 4 4 4 4 4 2 4 4 4 3 4 4 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Artery, Pancreatic, Thrombosis | 2 |
Lumbar, Hemorrhage | 1 |
Lumbar, Hyperplasia, Plasma Cell | 4 |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|
| 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Ectasia | 2 |
Mediastinal, Hemorrhage | 2 3 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage | 2 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Pigmentation | 1 1 |
Renal, Ectasia | |
Renal, Hemorrhage | 2 2 |
Renal, Hyperplasia, Lymphoid | |
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Ectasia | 4 |
Hemorrhage | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
Ectasia | |
Hemorrhage | 1 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 |
Pigmentation | 1 1 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + |
Congestion | |
Depletion Lymphoid | 3 2 3 2 3 |
Fibrosis | 4 1 3 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Pigmentation | 3 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + |
Congestion | 3 |
Depletion Lymphoid | 3 3 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
Hyperplasia | 2 2 1 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Skin | + + + + + + + |
Acanthosis | 3 |
Fibrosis | |
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|
| 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Cerebrum, Degeneration, Focal | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + |
Congestion | 4 |
Edema | |
Hemorrhage | 1 2 1 1 |
Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Mineralization | 1 1 1 1 1 1 |
Bronchiole, Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Metaplasia, Squamous | 1 2 |
Glands, Inflammation, Acute | 1 |
Lumen, Inflammation, Acute | 1 2 2 4 1 |
Mucosa, Congestion | 4 |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | I I |
Artery, Mineralization | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Hemorrhage | |
Hydronephrosis | |
Nephropathy | 4 4 3 4 4 2 3 3 3 3 2 3 3 4 3 3 3 2 3 2 |
Collecting Tubule, Mineralization | |
Proximal Convoluted Renal Tubule, | |
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 1| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 6| 7| 7| 5| 7| 7| 6| 6| 4|
DAY ON TEST | 9| 2| 2| 2| 6| 2| 2| 2| 6| 6| 0| 0| 9| 4| 0| 2| 7| 2| 0| 7| 2| 2| 9| 2| 6|
| 1| 9| 8| 4| 5| 9| 7| 4| 5| 3| 4| 4| 0| 3| 8| 9| 3| 9| 3| 4| 9| 9| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.0% MM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | |
Proximal Convoluted Renal Tubule, | |
Epithelium, Pigmentation | |
Renal Tubule, Hyperplasia, Cystic | 1 |
Renal Tubule, Hyperplasia | 1 |
Transitional Epithelium, Hyperplasia | 1 1 2 2 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 |
Artery, Mineralization | |
Subserosa, Mineralization | 1 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1| | |
DAY ON TEST | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9| | |
| 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 11 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + M + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + | 48 |
Epithelium, Pigmentation | 2 1 2 2 | 15 1.5|
Peyer's Patch, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M + M + + + + + + + + + + + + + | 43 |
Autolysis | | 1 3.0|
Epithelium, Pigmentation | | 2 1.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 50 |
Angiectasis | | 2 1.5|
Basophilic Focus | 1 1 1 1 1 1 | 18 1.1|
Clear Cell Focus | 1 | 5 1.0|
Cytoplasmic Alteration | 2 | 1 2.0|
Degeneration, Cystic | 1 1 | 9 1.1|
Degeneration | | 1 1.0|
Eosinophilic Focus | 1 | 7 1.4|
Fatty Change | 1 1 | 5 1.8|
Hemorrhage | 2 | 3 2.7|
Inflammation, Chronic | 1 1 1 1 2 1 1 1 1 | 26 1.0|
Mixed Cell Focus | 1 | 4 1.8|
Mixed Cell Focus, Multiple | 3 | 1 3.0|
Necrosis, Coagulative | 1 | 9 1.6|
Thrombosis | | 1 |
Bile Duct, Hyperplasia | 2 1 1 1 2 1 1 1 1 1 2 2 2 1 2 | 47 1.4|
Centrilobular, Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fibrosis | | 1 2.0|
Mineralization | | 1 1.0|
Necrosis, Coagulative | | 1 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + | 50 |
Atrophy | 1 1 2 2 1 2 | 23 1.3|
Cyst | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1| | |
DAY ON TEST | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9| | |
| 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fibrosis | | 2 2.0|
Hyperplasia | | 3 1.7|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 | 30 1.2|
Necrosis, Coagulative | | 1 3.0|
Pigmentation | | 2 1.0|
Thrombosis | | 1 2.0|
Artery, Inflammation, Chronic Active,| | |
Necrotizing | | 2 4.0|
Serosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 12 |
Parotid Gland, Vacuolization | | |
Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 49 |
Acanthosis | 3 | 2 2.5|
Hyperkeratosis | 3 | 2 2.5|
Hyperplasia, Basal Cell | 2 | 8 1.4|
Mineralization | 1 | 3 1.3|
Ulcer | 4 | 1 4.0|
Muscularis, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 49 |
Hemorrhage | | 1 1.0|
Necrosis, Coagulative | | 1 1.0|
Epithelium, Pigmentation | 1 1 | 3 1.0|
Mucosa, Mineralization | 2 | 3 3.0|
Muscularis, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + M + M + + + + | 47 |
Artery, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 18 |
Cardiomyopathy | 2 2 2 2 2 3 | 15 2.3|
Metaplasia, Osseous | 2 | 2 1.5|
Thrombosis | 2 | 5 3.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1| | |
DAY ON TEST | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9| | |
| 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 21 |
Angiectasis | | 2 2.0|
Hemorrhage | 4 | 1 4.0|
Hyperplasia | 1 | 1 1.0|
Necrosis, Coagulative | | 1 1.0|
Vacuolization Cytoplasmic | 1 2 2 | 8 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 21 |
Hyperplasia | | 3 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 13 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + I + + + + M + + + + + + + | 43 |
Hyperplasia | 2 3 | 6 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + | 50 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Autolysis | 2 | 2 2.5|
Pars Distalis, Congestion | | 1 2.0|
Pars Distalis, Cyst | 2 2 | 4 2.0|
Pars Distalis, Hyperplasia | 1 2 2 2 | 17 1.7|
Pars Distalis, Pigmentation | 1 | 1 1.0|
Pars Intermedia, Angiectasis | 2 | 3 2.7|
Pars Intermedia, Crystals | | 1 4.0|
Pars Intermedia, Cyst | 2 2 1 1 | 14 1.6|
Pars Intermedia, Ectopic Tissue | 2 | 1 2.0|
Pars Intermedia, Hyperplasia | 1 | 1 1.0|
Pars Nervosa, Ectopic Tissue | 2 | 1 2.0|
Pars Nervosa, Hyperplasia | | 1 2.0|
Rathke's Cleft, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 22 |
C-Cell, Hyperplasia | 2 1 2 | 6 1.3|
Follicle, Pigmentation | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 13 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 19 |
Abscess | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1| | |
DAY ON TEST | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9| | |
| 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 1 1 2 2 2 | 13 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 12 |
Inflammation, Chronic Active | 1 2 3 3 1 | 10 1.9|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 23 |
Atrophy | 3 3 | 9 2.4|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 48 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 41 1.1|
Seminiferous Tubule, Atrophy | 4 4 3 4 4 3 4 4 4 2 3 4 3 1 | 43 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 26 |
Artery, Pancreatic, Thrombosis | | 1 2.0|
Lumbar, Hemorrhage | | 1 1.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 4.0|
Mediastinal, Ectasia | 2 | 3 2.0|
Mediastinal, Hemorrhage | 2 | 3 2.3|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Mediastinal, Pigmentation | 1 | 2 1.0|
Pancreatic, Hemorrhage | | 2 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 2 1.5|
Pancreatic, Pigmentation | | 3 1.3|
Renal, Ectasia | 2 | 2 2.5|
Renal, Hemorrhage | 2 | 5 2.6|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Infiltration Cellular, | | |
Histiocyte | 1 | 2 1.5|
Renal, Pigmentation | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 15 |
Ectasia | 4 | 3 3.3|
Hemorrhage | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 17 |
Ectasia | | 1 2.0|
Hemorrhage | 2 | 4 1.8|
Infiltration Cellular, Histiocyte | 2 1 1 1 | 14 1.3|
Pigmentation | 1 1 1 1 | 10 1.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 38 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1| | |
DAY ON TEST | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9| | |
| 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | | 1 4.0|
Depletion Lymphoid | 2 4 3 3 | 13 2.6|
Fibrosis | | 8 2.6|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 1.0|
Pigmentation | | 1 3.0|
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 13 |
Congestion | | 1 3.0|
Depletion Lymphoid | 4 2 | 5 3.0|
Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + M M | 14 |
Hyperplasia | 1 2 2 | 9 1.7|
Pigmentation | | 3 1.0|
__________________________________________________________________________|____________|
Skin | + M + + + + + + M | 19 |
Acanthosis | | 1 3.0|
Fibrosis | | 1 2.0|
Hyperkeratosis | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | M + M + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 12 |
Cerebrum, Degeneration, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 31 |
Congestion | | 1 4.0|
Edema | 2 2 | 2 2.0|
Hemorrhage | 1 | 5 1.2|
Infiltration Cellular, Histiocyte | 1 4 1 1 1 | 18 1.2|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 6| 1| 6| 6| 6| 5| 5| 4| 1| | |
DAY ON TEST | 2| 2| 8| 6| 2| 2| 2| 2| 2| 2| 2| 9| 9| 1| 4| 7| 9| 4| 6| 9| | |
| 9| 7| 4| 5| 7| 9| 9| 8| 7| 0| 4| 5| 1| 7| 3| 3| 2| 9| 5| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.0% MM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 | 17 1.0|
Bronchiole, Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 49 |
Metaplasia, Squamous | | 2 1.5|
Glands, Inflammation, Acute | 1 | 4 1.0|
Lumen, Inflammation, Acute | 2 3 1 | 9 1.9|
Mucosa, Congestion | | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + + I I + | 6 |
Artery, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + | 50 |
Cyst | 1 | 1 1.0|
Hemorrhage | 4 | 1 4.0|
Hydronephrosis | 2 | 1 2.0|
Nephropathy | 3 3 4 1 3 4 4 3 2 3 3 2 3 4 3 2 | 50 3.0|
Collecting Tubule, Mineralization | | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Mineralization | | 2 3.0|
Proximal Convoluted Renal Tubule, | | |
Epithelium, Pigmentation | 1 2 2 | 3 1.7|
Renal Tubule, Hyperplasia, Cystic | | 1 1.0|
Renal Tubule, Hyperplasia | 1 | 2 1.0|
Transitional Epithelium, Hyperplasia | 2 2 1 2 2 | 16 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + M + + | 49 |
Inflammation, Chronic | | 1 1.0|
Artery, Mineralization | 2 | 1 2.0|
Subserosa, Mineralization | | 1 1.0|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 1| 7| 7| 6| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 6| 4| 3| 1|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 2| 7| 8| 8| 2| 2| 2| 8| 6| 2| 2| 2| 2| 6| 0| 2| 6| 2| 8|
| 7| 5| 0| 0| 9| 7| 9| 3| 9| 9| 9| 7| 7| 6| 5| 8| 8| 8| 9| 3| 4| 6| 3| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + A + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + M + A + + + + + + M + + + + + + + |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + A + + + + + + + |
Parasite Metazoan | |
Epithelium, Pigmentation | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + A + A + + + + + + A + + + + + + + |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small | + A + A + + + + + + A + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + A + + + + + + A + + + + + + + |
Epithelium, Pigmentation | |
__________________________________________________________________________|
Intestine Small, Ileum | + A + A + + + + + + A + + + + + + A |
Epithelium, Pigmentation | 3 2 1 2 2 2 1 2 2 2 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + A + + + + + + A + + + + + + A |
Epithelium, Pigmentation | 2 2 1 1 2 2 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 1 |
Clear Cell Focus | 1 1 1 1 1 |
Cyst | 2 |
Cyst Multilocular | |
Degeneration, Cystic | 1 2 |
Eosinophilic Focus | 2 1 |
Fatty Change | 1 1 1 1 1 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 1 1 1 1 1 1 |
Mixed Cell Focus | 4 |
Necrosis, Coagulative | 1 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 |
Centrilobular, Necrosis, Coagulative | 3 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic, Granulomatous | |
Inflammation, Chronic | 3 |
Mineralization | |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Pancreas | + M + + + + + + + + A + + + + + + A |
Atrophy | 1 1 1 1 1 2 2 3 |
Cyst | 1 |
Cytoplasmic Alteration | 1 1 |
Ectopic Liver | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 117
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 1| 7| 7| 6| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 6| 4| 3| 1|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 2| 7| 8| 8| 2| 2| 2| 8| 6| 2| 2| 2| 2| 6| 0| 2| 6| 2| 8|
| 7| 5| 0| 0| 9| 7| 9| 3| 9| 9| 9| 7| 7| 6| 5| 8| 8| 8| 9| 3| 4| 6| 3| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 1 1 1 1 2 1 |
Artery, Mineralization | |
__________________________________________________________________________|
Salivary Glands | + + M + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + |
Acanthosis | 1 |
Edema | |
Fibrosis | |
Hyperkeratosis | 1 |
Hyperplasia, Basal Cell | 1 |
Hyperplasia, Pseudoepitheliomatous | |
Inflammation, Chronic Active | |
Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
Edema | |
Inflammation, Chronic Active | |
Epithelium, Pigmentation | 2 2 1 2 1 2 2 2 1 2 |
Mucosa, Mineralization | 1 2 3 |
__________________________________________________________________________|
Tongue | M M + + + + + + + M + + + + + + + M |
Inflammation, Acute, Necrotizing | |
Artery, Mineralization | 1 |
Artery, Endothelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 3 2 2 2 1 3 2 3 2 3 2 2 2 1 2 |
Edema | |
Inflammation, Chronic | 1 |
Metaplasia, Osseous | |
Mineralization | 2 |
Thrombosis | 4 |
Artery, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 1 2 |
Congestion | 3 2 |
Hyperplasia | 2 1 1 1 1 1 1 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 1 2 1 1 1 1 2 1 1 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 118
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 1| 7| 7| 6| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 6| 4| 3| 1|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 2| 7| 8| 8| 2| 2| 2| 8| 6| 2| 2| 2| 2| 6| 0| 2| 6| 2| 8|
| 7| 5| 0| 0| 9| 7| 9| 3| 9| 9| 9| 7| 7| 6| 5| 8| 8| 8| 9| 3| 4| 6| 3| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | 1 |
Congestion | 3 2 |
Hyperplasia | 2 2 1 2 2 2 3 1 2 1 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + M + + + A |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + I + + + + + + + + M |
Hyperplasia | 4 2 3 4 3 2 |
__________________________________________________________________________|
Pituitary Gland | + A + + + + + + + + + + + + + + + + |
Autolysis | 2 2 |
Hemorrhage | |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 1 1 2 |
Pars Distalis, Hyperplasia | 1 2 2 1 1 2 1 |
Pars Intermedia, Cyst | 1 1 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 |
Follicle, Pigmentation | 1 1 1 |
Follicular Cell, Cyst | 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Hyperplasia | |
Inflammation, Chronic | 2 3 1 4 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + M + + + M + + + + + + + |
Fibrosis | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 4 3 2 3 3 1 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + M + + + + + + + |
Atrophy | 3 3 4 3 3 3 2 3 3 3 3 3 3 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + |
Necrosis, Coagulative | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
_____________________________________________________________________________________________________________________|
Page 119
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 1| 7| 7| 6| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 6| 4| 3| 1|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 2| 7| 8| 8| 2| 2| 2| 8| 6| 2| 2| 2| 2| 6| 0| 2| 6| 2| 8|
| 7| 5| 0| 0| 9| 7| 9| 3| 9| 9| 9| 7| 7| 6| 5| 8| 8| 8| 9| 3| 4| 6| 3| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Mediastinal, Depletion Lymphoid | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage | 1 |
Renal, Ectasia | |
Renal, Hemorrhage | 4 3 3 |
Renal, Hyperplasia, Plasma Cell | |
Renal, Infiltration Cellular, | |
Histiocyte | 2 2 |
Renal, Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + |
Congestion | 2 |
Depletion Lymphoid | 2 |
Ectasia | 2 2 2 4 |
Hemorrhage | 2 2 1 |
Hyperplasia, Plasma Cell | 3 |
Infiltration Cellular, Histiocyte | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + |
Ectasia | 4 4 4 4 |
Hemorrhage | 2 2 |
Infiltration Cellular, Histiocyte | 2 1 2 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | 3 2 2 1 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | M M |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + M |
Galactocele | |
Hyperplasia | 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Skin | + + + + + + + |
Acanthosis | 3 |
Hyperkeratosis | 4 |
Hyperplasia, Basal Cell | 2 |
Inflammation, Acute, Necrotizing | |
Subcutaneous Tissue, Abscess | 4 |
Subcutaneous Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 120
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 1| 7| 7| 6| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 6| 4| 3| 1|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 2| 7| 8| 8| 2| 2| 2| 8| 6| 2| 2| 2| 2| 6| 0| 2| 6| 2| 8|
| 7| 5| 0| 0| 9| 7| 9| 3| 9| 9| 9| 7| 7| 6| 5| 8| 8| 8| 9| 3| 4| 6| 3| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Granulomatous | |
Subcutaneous Tissue, Necrosis, | |
Coagulative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
Hemorrhage | 1 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Congestion | 4 |
Edema | 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 |
Metaplasia, Osseous | 1 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Metaplasia, Squamous | 2 |
Glands, Inflammation, Acute | 1 1 |
Lumen, Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Atrophy | |
Synechia | 4 |
Cornea, Fibrosis | |
Posterior Chamber, Inflammation, | |
Chronic | |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Congestion | 1 1 |
Cyst | 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 121
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 3| 7| 6| 1| 7| 7| 6| 1| 1| 7| 7| 7| 6| 4| 7| 7| 7| 7| 4| 7| 6| 4| 3| 1|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 2| 7| 8| 8| 2| 2| 2| 8| 6| 2| 2| 2| 2| 6| 0| 2| 6| 2| 8|
| 7| 5| 0| 0| 9| 7| 9| 3| 9| 9| 9| 7| 7| 6| 5| 8| 8| 8| 9| 3| 4| 6| 3| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 4 4 4 4 4 4 3 3 3 4 3 3 3 4 4 3 1 |
Interstitial Tissue, Inflammation, | |
Acute | 3 |
Proximal Convoluted Renal Tubule, | |
Mineralization | 2 |
Proximal Convoluted Renal Tubule, | |
Necrosis | |
Renal Tubule, Hyperplasia | 3 1 1 |
Transitional Epithelium, Hyperplasia | 2 2 2 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + + + + + M |
Calculus Micro Observation Only | |
Serosa, Mineralization | 1 |
Wall, Mucosa, Muscularis, | |
Inflammation, Acute, Diffuse, | |
Necrotizing | 4 |
_____________________________________________________________________________________________________________________|
Page 122
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 6| 1| 4| 1| 6| 5| 4| 4| 1| 7| 7| 6| 4| 4| 6| 6| 1| 5| 4|
DAY ON TEST | 2| 2| 2| 9| 7| 6| 1| 8| 6| 9| 9| 8| 6| 6| 9| 2| 2| 9| 6| 6| 7| 7| 9| 5| 6|
| 8| 9| 4| 7| 6| 7| 7| 9| 5| 1| 4| 1| 5| 3| 1| 3| 7| 3| 3| 3| 6| 4| 1| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4.0% HM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + |
Parasite Metazoan | 1 |
Epithelium, Pigmentation | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + |
Epithelium, Pigmentation | 1 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + |
Epithelium, Pigmentation | 1 2 1 2 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + |
Epithelium, Pigmentation | 2 1 2 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + |
Angiectasis | 1 |
Basophilic Focus | 1 1 1 |
Clear Cell Focus | |
Cyst | |
Cyst Multilocular | |
Degeneration, Cystic | |
Eosinophilic Focus | 1 |
Fatty Change | 1 |
Hemorrhage | 1 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 1 2 |
Thrombosis | 4 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 |
Centrilobular, Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic, Granulomatous | 4 |
Inflammation, Chronic | |
Mineralization | 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + |
Atrophy | 2 1 1 1 1 1 |
Cyst | |
Cytoplasmic Alteration | |
Ectopic Liver | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 123
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 6| 1| 4| 1| 6| 5| 4| 4| 1| 7| 7| 6| 4| 4| 6| 6| 1| 5| 4|
DAY ON TEST | 2| 2| 2| 9| 7| 6| 1| 8| 6| 9| 9| 8| 6| 6| 9| 2| 2| 9| 6| 6| 7| 7| 9| 5| 6|
| 8| 9| 4| 7| 6| 7| 7| 9| 5| 1| 4| 1| 5| 3| 1| 3| 7| 3| 3| 3| 6| 4| 1| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4.0% HM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 |
Artery, Mineralization | 3 |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + |
Acanthosis | 2 2 |
Edema | 4 |
Fibrosis | |
Hyperkeratosis | 2 2 |
Hyperplasia, Basal Cell | 2 |
Hyperplasia, Pseudoepitheliomatous | 2 |
Inflammation, Chronic Active | 2 2 |
Mineralization | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + |
Edema | 3 |
Inflammation, Chronic Active | 2 |
Epithelium, Pigmentation | 2 2 1 2 1 2 2 2 2 3 2 |
Mucosa, Mineralization | 4 4 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + M + + + + |
Inflammation, Acute, Necrotizing | 2 |
Artery, Mineralization | 2 2 |
Artery, Endothelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 3 2 2 2 3 3 1 2 1 2 2 2 1 |
Edema | 2 |
Inflammation, Chronic | |
Metaplasia, Osseous | |
Mineralization | 2 |
Thrombosis | |
Artery, Mineralization | 4 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + M + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + M + + + + + + + + + |
Angiectasis | 1 |
Congestion | |
Hyperplasia | 1 1 1 1 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 1 1 3 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 124
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 6| 1| 4| 1| 6| 5| 4| 4| 1| 7| 7| 6| 4| 4| 6| 6| 1| 5| 4|
DAY ON TEST | 2| 2| 2| 9| 7| 6| 1| 8| 6| 9| 9| 8| 6| 6| 9| 2| 2| 9| 6| 6| 7| 7| 9| 5| 6|
| 8| 9| 4| 7| 6| 7| 7| 9| 5| 1| 4| 1| 5| 3| 1| 3| 7| 3| 3| 3| 6| 4| 1| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4.0% HM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | |
Congestion | |
Hyperplasia | 2 2 2 2 1 2 2 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M |
Hyperplasia | 3 3 3 3 3 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + |
Autolysis | 2 |
Hemorrhage | 3 |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 2 |
Pars Intermedia, Cyst | 1 1 1 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 1 |
Follicle, Pigmentation | 1 |
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Hyperplasia | 2 |
Inflammation, Chronic | 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + |
Fibrosis | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 2 3 2 1 3 1 4 1 |
Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + |
Atrophy | 3 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + |
Necrosis, Coagulative | 4 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 3 4 4 3 4 4 3 4 1 3 4 4 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
_____________________________________________________________________________________________________________________|
Page 125
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 6| 1| 4| 1| 6| 5| 4| 4| 1| 7| 7| 6| 4| 4| 6| 6| 1| 5| 4|
DAY ON TEST | 2| 2| 2| 9| 7| 6| 1| 8| 6| 9| 9| 8| 6| 6| 9| 2| 2| 9| 6| 6| 7| 7| 9| 5| 6|
| 8| 9| 4| 7| 6| 7| 7| 9| 5| 1| 4| 1| 5| 3| 1| 3| 7| 3| 3| 3| 6| 4| 1| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4.0% HM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Mediastinal, Depletion Lymphoid | |
Mediastinal, Hemorrhage | 1 1 |
Mediastinal, Pigmentation | 1 |
Pancreatic, Hemorrhage | 2 |
Renal, Ectasia | 4 |
Renal, Hemorrhage | |
Renal, Hyperplasia, Plasma Cell | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M |
Congestion | |
Depletion Lymphoid | |
Ectasia | 2 2 2 |
Hemorrhage | 3 3 4 1 1 |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Histiocyte | 1 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
Ectasia | 4 4 4 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 2 1 2 2 |
Pigmentation | 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Depletion Lymphoid | 2 4 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + |
Depletion Lymphoid | 3 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + |
Galactocele | 2 |
Hyperplasia | 2 2 2 2 |
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + |
Acanthosis | 2 |
Hyperkeratosis | 4 |
Hyperplasia, Basal Cell | |
Inflammation, Acute, Necrotizing | |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 126
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 6| 1| 4| 1| 6| 5| 4| 4| 1| 7| 7| 6| 4| 4| 6| 6| 1| 5| 4|
DAY ON TEST | 2| 2| 2| 9| 7| 6| 1| 8| 6| 9| 9| 8| 6| 6| 9| 2| 2| 9| 6| 6| 7| 7| 9| 5| 6|
| 8| 9| 4| 7| 6| 7| 7| 9| 5| 1| 4| 1| 5| 3| 1| 3| 7| 3| 3| 3| 6| 4| 1| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4.0% HM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Granulomatous | 3 |
Subcutaneous Tissue, Necrosis, | |
Coagulative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + |
Hemorrhage | 1 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + |
Congestion | |
Edema | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Bronchiole, Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + |
Metaplasia, Squamous | |
Glands, Inflammation, Acute | 2 1 |
Lumen, Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Atrophy | 4 |
Synechia | |
Cornea, Fibrosis | 3 |
Posterior Chamber, Inflammation, | |
Chronic | 4 |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + |
Congestion | |
Cyst | |
_____________________________________________________________________________________________________________________|
Page 127
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 6| 6| 1| 4| 1| 6| 5| 4| 4| 1| 7| 7| 6| 4| 4| 6| 6| 1| 5| 4|
DAY ON TEST | 2| 2| 2| 9| 7| 6| 1| 8| 6| 9| 9| 8| 6| 6| 9| 2| 2| 9| 6| 6| 7| 7| 9| 5| 6|
| 8| 9| 4| 7| 6| 7| 7| 9| 5| 1| 4| 1| 5| 3| 1| 3| 7| 3| 3| 3| 6| 4| 1| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
4.0% HM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 3 3 3 1 4 4 4 4 4 2 4 4 4 3 2 |
Interstitial Tissue, Inflammation, | |
Acute | |
Proximal Convoluted Renal Tubule, | |
Mineralization | 3 2 |
Proximal Convoluted Renal Tubule, | |
Necrosis | |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | 1 2 2 2 1 2 1 2 2 |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + |
Calculus Micro Observation Only | X |
Serosa, Mineralization | |
Wall, Mucosa, Muscularis, | |
Inflammation, Acute, Diffuse, | |
Necrotizing | |
_____________________________________________________________________________________________________________________|
Page 128
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 1| 6| 4| | |
DAY ON TEST | 2| 2| 2| 6| 7| 2| 2| 1| 1| 9| 2| 2| 2| 2| 2| 2| 9| 9| 9| 6| | |
| 8| 2| 4| 2| 4| 4| 3| 5| 3| 8| 8| 8| 9| 9| 4| 8| 1| 1| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + I + + + + + I | 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 46 |
Parasite Metazoan | 1 X | 4 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 47 |
Parasite Metazoan | 1 1 | 3 1.0|
Epithelium, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + | 46 |
Parasite Metazoan | | 4 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + | 46 |
Epithelium, Pigmentation | 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + | 45 |
Epithelium, Pigmentation | 2 2 2 2 1 1 2 2 2 2 2 | 28 1.8|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + M + + + + + + + + + + + + + | 44 |
Epithelium, Pigmentation | 1 1 2 1 1 2 | 19 1.6|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 50 |
Angiectasis | | 2 1.0|
Basophilic Focus | 1 1 1 1 1 | 20 1.0|
Clear Cell Focus | 1 1 1 | 8 1.0|
Cyst | | 1 2.0|
Cyst Multilocular | 1 | 1 1.0|
Degeneration, Cystic | | 2 1.5|
Eosinophilic Focus | | 3 1.3|
Fatty Change | 1 2 | 8 1.1|
Hemorrhage | | 3 1.3|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic | 2 1 1 1 1 1 1 1 | 23 1.1|
Mixed Cell Focus | 3 1 | 3 2.7|
Necrosis, Coagulative | 1 1 | 7 1.3|
Thrombosis | | 1 4.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 | 30 1.0|
Centrilobular, Necrosis, Coagulative | | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Inflammation, Chronic, Granulomatous | 4 | 2 4.0|
Inflammation, Chronic | | 1 3.0|
Mineralization | | 1 2.0|
Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 129
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 1| 6| 4| | |
DAY ON TEST | 2| 2| 2| 6| 7| 2| 2| 1| 1| 9| 2| 2| 2| 2| 2| 2| 9| 9| 9| 6| | |
| 8| 2| 4| 2| 4| 4| 3| 5| 3| 8| 8| 8| 9| 9| 4| 8| 1| 1| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy | 1 1 1 2 2 2 1 2 2 3 | 24 1.5|
Cyst | | 1 1.0|
Cytoplasmic Alteration | 1 | 3 1.0|
Ectopic Liver | X | 1 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 | 34 1.1|
Artery, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 46 |
Acanthosis | 2 1 | 5 1.6|
Edema | | 1 4.0|
Fibrosis | 1 | 1 1.0|
Hyperkeratosis | 2 1 | 5 1.6|
Hyperplasia, Basal Cell | | 2 1.5|
Hyperplasia, Pseudoepitheliomatous | | 1 2.0|
Inflammation, Chronic Active | 2 | 3 2.0|
Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + I + + + + + + + | 48 |
Edema | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Epithelium, Pigmentation | 2 2 2 2 2 2 1 2 2 1 2 1 1 | 34 1.8|
Mucosa, Mineralization | 4 2 | 7 2.9|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + M + + + | 44 |
Inflammation, Acute, Necrotizing | | 1 2.0|
Artery, Mineralization | 2 | 4 1.8|
Artery, Endothelium, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Aorta, Mineralization | 4 | 2 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 50 |
Cardiomyopathy | 2 1 3 2 2 1 1 1 2 1 1 2 1 3 3 4 1 | 49 2.0|
Edema | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | | 2 2.0|
Thrombosis | | 1 4.0|
Artery, Mineralization | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 130
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 1| 6| 4| | |
DAY ON TEST | 2| 2| 2| 6| 7| 2| 2| 1| 1| 9| 2| 2| 2| 2| 2| 2| 9| 9| 9| 6| | |
| 8| 2| 4| 2| 4| 4| 3| 5| 3| 8| 8| 8| 9| 9| 4| 8| 1| 1| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | 1 1 1 1 | 8 1.1|
Congestion | | 2 2.5|
Hyperplasia | 1 1 1 | 14 1.1|
Necrosis, Coagulative | 4 | 1 4.0|
Vacuolization Cytoplasmic | 1 3 1 1 1 1 2 1 1 1 | 27 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + | 49 |
Angiectasis | | 1 1.0|
Congestion | | 2 2.5|
Hyperplasia | 1 1 1 | 21 1.7|
Necrosis, Coagulative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 41 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + I + I + + + + + M + + + + + + + | 43 |
Hyperplasia | 2 2 4 | 17 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 48 |
Autolysis | | 3 2.0|
Hemorrhage | | 1 3.0|
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | 2 3 1 | 7 1.6|
Pars Distalis, Hyperplasia | 2 1 2 2 2 1 1 1 2 1 1 1 | 20 1.5|
Pars Intermedia, Cyst | 1 1 | 7 1.0|
Pars Nervosa, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 49 |
C-Cell, Hyperplasia | 1 1 1 1 1 2 | 16 1.1|
Follicle, Pigmentation | 1 1 | 6 1.0|
Follicular Cell, Cyst | 3 | 3 2.0|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 15 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 131
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 1| 6| 4| | |
DAY ON TEST | 2| 2| 2| 6| 7| 2| 2| 1| 1| 9| 2| 2| 2| 2| 2| 2| 9| 9| 9| 6| | |
| 8| 2| 4| 2| 4| 4| 3| 5| 3| 8| 8| 8| 9| 9| 4| 8| 1| 1| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 3 4 3 | 13 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + | 48 |
Fibrosis | 1 | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 2 2 3 2 2 4 1 1 1 1 1 1 4 | 30 2.2|
Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + | 49 |
Atrophy | 3 2 3 3 2 3 2 3 3 2 3 3 3 3 | 39 2.9|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + | 50 |
Necrosis, Coagulative | | 1 4.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 44 1.0|
Seminiferous Tubule, Atrophy | 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4 4 | 46 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 9 |
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + | 50 |
Mediastinal, Depletion Lymphoid | | 1 3.0|
Mediastinal, Hemorrhage | 1 1 1 4 | 6 1.5|
Mediastinal, Pigmentation | | 1 1.0|
Pancreatic, Hemorrhage | | 2 1.5|
Renal, Ectasia | | 1 4.0|
Renal, Hemorrhage | 2 1 | 5 2.6|
Renal, Hyperplasia, Plasma Cell | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
Renal, Pigmentation | 1 2 | 5 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + | 47 |
Congestion | | 1 2.0|
Depletion Lymphoid | | 1 2.0|
Ectasia | 2 1 2 | 10 2.1|
Hemorrhage | 3 2 3 1 | 12 2.2|
Hyperplasia, Plasma Cell | | 1 3.0|
Infiltration Cellular, Histiocyte | 1 1 | 3 1.0|
Pigmentation | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 19 |
Ectasia | 4 3 2 4 | 12 3.6|
Hemorrhage | | 3 2.0|
Infiltration Cellular, Histiocyte | 2 | 9 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 132
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 1| 6| 4| | |
DAY ON TEST | 2| 2| 2| 6| 7| 2| 2| 1| 1| 9| 2| 2| 2| 2| 2| 2| 9| 9| 9| 6| | |
| 8| 2| 4| 2| 4| 4| 3| 5| 3| 8| 8| 8| 9| 9| 4| 8| 1| 1| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation | 1 | 8 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 50 |
Depletion Lymphoid | 2 4 | 9 2.4|
Fibrosis | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | M + | 5 |
Depletion Lymphoid | 2 | 5 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 9 |
Galactocele | | 1 2.0|
Hyperplasia | 1 | 6 1.8|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + | 18 |
Acanthosis | 2 | 3 2.3|
Hyperkeratosis | 4 | 3 4.0|
Hyperplasia, Basal Cell | | 1 2.0|
Inflammation, Acute, Necrotizing | 4 | 1 4.0|
Subcutaneous Tissue, Abscess | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | | 1 3.0|
Subcutaneous Tissue, Necrosis, | | |
Coagulative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 23 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 50 |
Hemorrhage | | 2 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 50 |
Congestion | | 1 4.0|
Edema | | 1 2.0|
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 | 43 1.1|
Metaplasia, Osseous | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 133
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 1| 6| 4| | |
DAY ON TEST | 2| 2| 2| 6| 7| 2| 2| 1| 1| 9| 2| 2| 2| 2| 2| 2| 9| 9| 9| 6| | |
| 8| 2| 4| 2| 4| 4| 3| 5| 3| 8| 8| 8| 9| 9| 4| 8| 1| 1| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 1 | 3 1.0|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 43 1.0|
Bronchiole, Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 49 |
Metaplasia, Squamous | | 1 2.0|
Glands, Inflammation, Acute | 1 | 5 1.2|
Lumen, Inflammation, Acute | 2 | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 3 |
Atrophy | | 1 4.0|
Synechia | | 1 4.0|
Cornea, Fibrosis | | 1 3.0|
Posterior Chamber, Inflammation, | | |
Chronic | | 1 4.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 50 |
Congestion | | 2 1.0|
Cyst | 1 1 | 7 1.6|
Nephropathy | 4 2 3 4 2 2 4 4 2 3 3 2 3 3 4 4 4 | 49 3.3|
Interstitial Tissue, Inflammation, | | |
Acute | | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Mineralization | 2 2 | 5 2.2|
Proximal Convoluted Renal Tubule, | | |
Necrosis | 3 | 1 3.0|
Renal Tubule, Hyperplasia | 4 | 4 2.3|
Transitional Epithelium, Hyperplasia | 1 2 2 1 1 2 2 2 | 27 1.7|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 48 |
Calculus Micro Observation Only | | 1 |
Serosa, Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 134
NTP Experiment-Test: 05033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC QUERCETIN Date: 04/28/97
Route: DOSED FEED Time: 14:51:15
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 1| 6| 4| | |
DAY ON TEST | 2| 2| 2| 6| 7| 2| 2| 1| 1| 9| 2| 2| 2| 2| 2| 2| 9| 9| 9| 6| | |
| 8| 2| 4| 2| 4| 4| 3| 5| 3| 8| 8| 8| 9| 9| 4| 8| 1| 1| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
4.0% HM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Wall, Mucosa, Muscularis, | | |
Inflammation, Acute, Diffuse, | | |
Necrotizing | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 135
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------