TDMS Study 05033-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/04/94
EXP: 05033 QUERCETIN TIME: 20:46:15
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 60106
CONT: N01CP9561903 CAS: 117-39-5
PATHOLOGIST: R. FLEISCHMAN S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
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TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/04/94
EXP: 05033 QUERCETIN TIME: 20:46:15
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 60106
CONT: N01CP9561903 CAS: 117-39-5
PATHOLOGIST: R. FLEISCHMAN S. EUSTIS
QUERCETIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 724 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL UM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 24 CENSORED DEATHS 20 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 226 458 519 562 573 575 590 620 636 636 |
| 640 654 654 656 664 674 679 682 689 704 |
| 717 717 720 721 |
| CENSORED DEATHS |
| 189 189 189 189 189 189 189 191 191 191 |
| 463 463 465 465 465 465 465 465 465 465 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 22 CENSORED DEATHS 20 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 458 509 546 556 562 572 584 599 618 618 |
| 620 643 654 671 678 685 695 704 716 720 |
| 721 723 |
| CENSORED DEATHS |
| 189 189 189 189 189 191 191 191 191 191 |
| 463 463 463 463 463 465 465 465 465 465 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 25 CENSORED DEATHS 20 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 420 427 549 555 555 574 592 608 617 624 |
| 643 643 673 673 674 674 680 684 687 690 |
| 695 699 703 704 704 |
| CENSORED DEATHS |
| 189 189 189 189 189 191 191 191 191 191 |
| 463 463 463 463 463 465 465 465 465 465 |
| |
==================================================================================
QUERCETIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 724 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 4.0% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 27 CENSORED DEATHS 20 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 315 326 422 555 574 581 617 626 662 667 |
| 673 674 676 676 686 690 692 693 694 697 |
| 698 700 704 713 715 723 723 |
| CENSORED DEATHS |
| 189 189 189 189 189 191 191 191 191 191 |
| 463 463 463 463 463 463 463 465 465 465 |
| |
==================================================================================
QUERCETIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 724 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 724 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL UM | 100.0 100.0 98.3 98.3 98.3 96.7 94.7 86.6 70.5 52.4 |
| | |
| | |
|0.1% | 100.0 100.0 100.0 100.0 100.0 98.3 96.3 84.3 74.3 56.2 |
| | |
| | |
|1.0% | 100.0 100.0 100.0 100.0 98.3 96.7 96.7 86.6 76.5 50.3 |
| | |
| | |
|4.0% | 100.0 100.0 100.0 96.7 95.0 95.0 95.0 88.9 82.9 46.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL UM 0.1% 1.0% 4.0% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.4% 56.2% 50.3% 46.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.603 P=0.838N P=0.940 P=0.824 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 623.6 629.6 629.9 636.0 |
|NATURAL DEATHS (C) | (22.0) (16.0) (16.0) (21.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 576.2 580.9 577.0 576.6 |
|(STANDARD ERROR) | (22.8) (22.3) (22.2) (22.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
QUERCETIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 723 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL UF |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 20 CENSORED DEATHS 20 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 422 597 606 613 619 625 632 641 660 660 |
| 672 672 686 687 687 700 700 718 718 718 |
| CENSORED DEATHS |
| 191 191 191 191 191 193 193 193 193 193 |
| 464 464 464 464 464 466 466 466 466 466 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.1% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 22 CENSORED DEATHS 20 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 497 504 515 543 548 596 597 603 603 612 |
| 613 626 645 668 676 680 680 683 687 696 |
| 704 721 |
| CENSORED DEATHS |
| 191 191 191 191 191 193 193 193 193 193 |
| 464 464 464 464 464 464 466 466 466 466 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 15 CENSORED DEATHS 20 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 337 441 521 548 548 603 605 660 666 685 |
| 697 697 707 709 718 |
| CENSORED DEATHS |
| 191 191 191 191 191 193 193 193 193 193 |
| 464 464 464 464 464 466 466 466 466 466 |
| |
==================================================================================
QUERCETIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 723 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 4.0% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 22 CENSORED DEATHS 20 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 284 457 492 549 553 560 594 597 623 630 |
| 632 637 660 667 668 686 688 688 688 715 |
| 716 716 |
| CENSORED DEATHS |
| 191 191 191 191 191 193 193 193 193 193 |
| 464 464 464 466 466 466 466 466 466 466 |
| |
==================================================================================
QUERCETIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 723 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 723 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL UF | 100.0 100.0 100.0 100.0 98.3 98.3 98.3 96.3 80.3 60.2 |
| | |
| | |
|0.1% | 100.0 100.0 100.0 100.0 100.0 100.0 92.0 82.0 74.0 56.0 |
| | |
| | |
|1.0% | 100.0 100.0 100.0 98.3 98.3 96.7 94.7 86.6 84.6 70.5 |
| | |
| | |
|4.0% | 100.0 100.0 100.0 98.3 98.3 96.7 94.7 84.6 74.5 56.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL UF 0.1% 1.0% 4.0% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.2% 56.0% 70.5% 56.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.704 P=0.614 P=0.455N P=0.656 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 651.7 622.6 609.5 613.6 |
|NATURAL DEATHS (C) | (14.9) (14.5) (29.0) (21.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 589.9 578.7 586.0 576.0 |
|(STANDARD ERROR) | (22.4) (22.0) (22.9) (22.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
QUERCETIN
KAPLAN-MEIER SURVIVAL CURVES
CONTROL UM = 1
0.1% = 2
1.0% = 3
4.0% = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 4 3 2
| 1 4 4 33 1 2 1 23
| 4 1 2321
| 211
P 90 + 3211 4
E | 212 123 14
R | 23 141 4
C | 33 44
E 80 + 311 44
N | 2 1 1 3
T | 2 2
| 1 1224
S 70 + 1 124
U | 11 2
R | 1122 2
V | 1 1
I 60 + 331 1
V | 33 22
A | 44 2
L | 411
50 + 3 43
| 4
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 47 obs hidden.
QUERCETIN
KAPLAN-MEIER SURVIVAL CURVES
CONTROL UF = 1
0.1% = 2
1.0% = 3
4.0% = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 1 2
| 4 3 1 3 4 1
| 22
| 3 4 42 2 3 11
95 + 4 3 3
| 2 2 11
| 22 11
| 34 3
90 + 2 2 11
| 4 4 11
P |
E | 422 11 3
R 85 + 4 4 33
C | 1 1
E | 2244 3 3
N |
T 80 + 44 11 3 3
|
S | 2 2
U | 24 2 41 1 33
R 75 + 44 33
V | 2 2 11
I | 22 33
V |
A 70 + 42211 33
L | 44
|
| 1 1
65 +
| 22
| 22 4
|
60 + 22 11
|
| 2 2
| 22
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.