TDMS Study 05035-02 Pathology Tables
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
Facility: TSI Mason Research
Chemical CAS #: 103-90-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 0| 3| 3| 9| 3| 6| 4| 4| 5| 3| 3| 3| 3| 3| 3| 3| 1| 0| 5| 3| 3| 1| 5| 5|
| 2| 2| 4| 6| 1| 3| 0| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 9| 6| 7| 3| 3| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + M + + |
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + + + M + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis, Focal | |
Clear Cell Focus | |
Congestion | 3 |
Cytoplasmic Alteration, Focal | 3 |
Fatty Change | 3 2 2 2 2 |
Hematopoietic Cell Proliferation | 3 3 |
Inflammation, Acute | |
Necrosis, Focal | 4 3 1 2 1 |
Perivascular, Inflammation, Chronic | 2 1 1 2 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Acute | 3 |
Fat, Necrosis | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 1 2 2 2 2 2 2 1 2 |
Acinus, Atrophy | |
Acinus, Hyperplasia | 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + M + + + + M + + + + + + + + + + + M + + |
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 2 3 2 2 3 2 3 2 2 3 2 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 3 2 |
Hyperkeratosis | 3 3 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + M + + + + |
Inflammation, Chronic | 1 1 2 1 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 0| 3| 3| 9| 3| 6| 4| 4| 5| 3| 3| 3| 3| 3| 3| 3| 1| 0| 5| 3| 3| 1| 5| 5|
| 2| 2| 4| 6| 1| 3| 0| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 9| 6| 7| 3| 3| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Coronary Artery, Inflammation, Acute | |
Pericardium, Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
Capsule, Hyperplasia | 4 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | |
Cytoplasmic Alteration, Focal | |
Hematopoietic Cell Proliferation | 3 |
Vacuolization Cytoplasmic | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 3 1 |
__________________________________________________________________________|
Parathyroid Gland | + M M + M M M + M + M M + + + + M + I + + |
__________________________________________________________________________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hyperplasia, Focal | 2 3 4 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + M + + + + M + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 1 1 1 |
Follicular Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + M + + + + + |
Abscess | 4 |
Cyst | X X X X X X |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Corpus Luteum, Hypertrophy | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Abscess | 2 4 |
Dilatation | 4 3 |
Inflammation, Acute | 2 |
Endometrium, Angiectasis | |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 2 3 2 4 4 3 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 0| 3| 3| 9| 3| 6| 4| 4| 5| 3| 3| 3| 3| 3| 3| 3| 1| 0| 5| 3| 3| 1| 5| 5|
| 2| 2| 4| 6| 1| 3| 0| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 9| 6| 7| 3| 3| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | 2 2 2 |
Myelofibrosis | 2 1 3 2 2 2 2 2 2 3 2 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Lumbar, Congestion | 1 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 3 |
Lumbar, Inflammation, Acute | |
Mediastinal, Abscess | |
Mediastinal, Hyperplasia, Lymphoid | 4 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Renal, Angiectasis | 2 |
Renal, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + M + + M + M + M + + + + + + + M + |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 1 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + |
Congestion | 2 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 4 4 3 2 2 2 3 2 2 2 4 |
Hyperplasia, Lymphoid | 4 3 2 2 2 4 |
__________________________________________________________________________|
Thymus | M M + + M M M + + M M + M + M + + + M + M |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + M M + + M M + + M M M + M M M + |
__________________________________________________________________________|
Skin | M + + + + + + + + + + + + + + + + + M + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Hydrocephalus | |
Mineralization, Focal | 2 1 2 2 1 2 2 2 2 1 1 |
Artery, Inflammation, Chronic | |
Choroid Plexus, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 6| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 0| 3| 3| 9| 3| 6| 4| 4| 5| 3| 3| 3| 3| 3| 3| 3| 1| 0| 5| 3| 3| 1| 5| 5|
| 2| 2| 4| 6| 1| 3| 0| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 9| 6| 7| 3| 3| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hemorrhage, Focal | 2 |
Infiltration Cellular, Histiocyte | |
Perivascular, Inflammation, Chronic | 3 2 2 2 2 2 2 2 3 2 2 2 1 |
Pleura, Inflammation, Acute | 4 |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + M + M |
Inflammation, Chronic | 2 |
Metaplasia, Squamous | 3 2 2 2 2 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + M + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 2 1 |
Glomerulosclerosis | 3 4 3 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 2 2 2 3 2 2 2 3 2 1 |
Artery, Inflammation, Chronic | |
Cortex, Necrosis, Focal | 2 |
Renal Tubule, Regeneration | 3 2 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 3 2 1 2 2 2 2 2 2 2 1 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 5| 5| 4| 3| 7| 7| 7| 7| 5| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 5| 9| 3| 3| 3| 3| 6| 3| 8| 5| 5| 5| 3| 3| 3| 5| 5| 3| 3| 2| 0| 4|
| 3| 5| 4| 8| 7| 3| 3| 3| 3| 4| 3| 4| 3| 8| 7| 3| 3| 5| 8| 8| 3| 3| 6| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + M + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 2 |
Clear Cell Focus | |
Congestion | |
Cytoplasmic Alteration, Focal | |
Fatty Change | 1 2 1 3 |
Hematopoietic Cell Proliferation | 4 1 4 2 |
Inflammation, Acute | 2 |
Necrosis, Focal | 1 2 1 3 1 3 |
Perivascular, Inflammation, Chronic | 2 2 2 2|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Acute | |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 3 1 3 3 2 1 3|
Acinus, Atrophy | 2 4 3 |
Acinus, Hyperplasia | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic, Focal | 2 2 3 3 1 2 3 2 1 2 2 1 3 3|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Hyperkeratosis | 3 |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 |
Inflammation, Chronic, Focal | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 5| 5| 4| 3| 7| 7| 7| 7| 5| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 5| 9| 3| 3| 3| 3| 6| 3| 8| 5| 5| 5| 3| 3| 3| 5| 5| 3| 3| 2| 0| 4|
| 3| 5| 4| 8| 7| 3| 3| 3| 3| 4| 3| 4| 3| 8| 7| 3| 3| 5| 8| 8| 3| 3| 6| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Coronary Artery, Inflammation, Acute | 4 |
Pericardium, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 4 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Cytoplasmic Alteration, Focal | 1 |
Hematopoietic Cell Proliferation | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M M M + + + M + M M + M + + + M + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + I|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 3 2 1 1 4 3 |
Pars Distalis, Hyperplasia | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Follicular Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + I + + + +|
Abscess | 4 4 4 3 |
Cyst | X X X X X X |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 4 |
Corpus Luteum, Hypertrophy | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Dilatation | 4 |
Inflammation, Acute | |
Endometrium, Angiectasis | 3 4 |
Endometrium, Hyperplasia, Cystic | 2 1 3 3 1 2 2 2 3 2 4 4 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 5| 5| 4| 3| 7| 7| 7| 7| 5| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 5| 9| 3| 3| 3| 3| 6| 3| 8| 5| 5| 5| 3| 3| 3| 5| 5| 3| 3| 2| 0| 4|
| 3| 5| 4| 8| 7| 3| 3| 3| 3| 4| 3| 4| 3| 8| 7| 3| 3| 5| 8| 8| 3| 3| 6| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | 4 4 3 4 2 |
Myelofibrosis | 2 3 2 2 1 2 1 1 1 3 3 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Lumbar, Congestion | |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 4 2 3 |
Lumbar, Inflammation, Acute | 2 |
Mediastinal, Abscess | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 4 |
Renal, Angiectasis | |
Renal, Infiltration Cellular, Plasma | |
Cell | 4 4 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 3 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + M|
Congestion | 3 1 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Acute | 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 2 2 2 4 3 4 2 2 2 4 4 4|
Hyperplasia, Lymphoid | 1 2 |
__________________________________________________________________________|
Thymus | M + + M + M M + M + M M + + + + M M M M|
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, Plasma Cell | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + M + M + M M + M + M + + M + +|
__________________________________________________________________________|
Skin | M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 |
Mineralization, Focal | 2 2 1 1 2 2 |
Artery, Inflammation, Chronic | |
Choroid Plexus, Inflammation, | |
Chronic, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 5| 5| 4| 3| 7| 7| 7| 7| 5| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 5| 9| 3| 3| 3| 3| 6| 3| 8| 5| 5| 5| 3| 3| 3| 5| 5| 3| 3| 2| 0| 4|
| 3| 5| 4| 8| 7| 3| 3| 3| 3| 4| 3| 4| 3| 8| 7| 3| 3| 5| 8| 8| 3| 3| 6| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Focal | |
Infiltration Cellular, Histiocyte | 2 |
Perivascular, Inflammation, Chronic | 2 2 2 1 2 2 2 3 2 2 3 2 3 4|
Pleura, Inflammation, Acute | 3 |
Pleura, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Metaplasia, Squamous | 2 3 2 2 2 2 2 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 2 2 2 1 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Glomerulosclerosis | 4 3 3 3 4 3 3 |
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic, Focal | 3 2 2 1 2 2 2 1 4 3 2|
Artery, Inflammation, Chronic | |
Cortex, Necrosis, Focal | |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 3 3 2 2 2 2 2 2 2 2 2 2 2 3 3|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3| | |
| 3| 3| 3| 5| 7| 3| 3| 3| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + M M + + M + | 42 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + A + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M + + + A + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + A + | 49 |
Angiectasis, Focal | | 2 2.5|
Clear Cell Focus | 3 | 1 3.0|
Congestion | | 1 3.0|
Cytoplasmic Alteration, Focal | | 1 3.0|
Fatty Change | | 9 2.0|
Hematopoietic Cell Proliferation | | 6 2.8|
Inflammation, Acute | | 1 2.0|
Necrosis, Focal | 1 2 1 | 14 1.9|
Perivascular, Inflammation, Chronic | 4 | 9 2.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Acute | | 1 3.0|
Fat, Necrosis | | 3 3.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + M + | 49 |
Inflammation, Chronic, Focal | 1 2 2 2 | 21 2.0|
Acinus, Atrophy | 2 | 4 2.8|
Acinus, Hyperplasia | | 1 2.0|
Duct, Ectasia | 4 | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M | 46 |
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Chronic, Focal | 2 2 1 2 1 2 | 33 2.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + M M | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + M M | 48 |
Acanthosis | | 3 3.0|
Hyperkeratosis | | 4 2.8|
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + M M | 47 |
Inflammation, Chronic | 2 2 2 | 9 1.7|
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3| | |
| 3| 3| 3| 5| 7| 3| 3| 3| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Cardiomyopathy | | 1 3.0|
Inflammation, Chronic, Focal | | 3 1.0|
Coronary Artery, Inflammation, Acute | | 1 4.0|
Pericardium, Inflammation, Acute | | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + A + | 49 |
Capsule, Hyperplasia | | 2 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + A + | 49 |
Accessory Adrenal Cortical Nodule | | 1 |
Cytoplasmic Alteration, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Vacuolization Cytoplasmic | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + M + M A + | 46 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + M + | 48 |
Hyperplasia | 2 | 7 1.9|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M M + M M + | 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + | 46 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 2 2 2 4 | 13 2.5|
Pars Distalis, Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 48 |
Inflammation, Chronic, Focal | 1 | 4 1.0|
Follicular Cell, Hyperplasia, Focal | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + A + | 47 |
Abscess | | 5 3.8|
Cyst | X X X X X | 17 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 4.0|
Corpus Luteum, Hypertrophy | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3| | |
| 3| 3| 3| 5| 7| 3| 3| 3| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + A + | 49 |
Abscess | | 3 3.0|
Dilatation | | 3 3.7|
Inflammation, Acute | 3 | 2 2.5|
Endometrium, Angiectasis | | 2 3.5|
Endometrium, Hyperplasia, Cystic | 2 2 1 2 3 2 | 33 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + A + | 49 |
Hyperplasia, Neutrophil | | 8 2.9|
Myelofibrosis | 2 2 1 1 3 | 30 1.9|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + A + | 49 |
Lumbar, Congestion | | 1 1.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 4 3.0|
Lumbar, Inflammation, Acute | | 1 2.0|
Mediastinal, Abscess | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
Renal, Angiectasis | | 1 2.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 3 3.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + A + | 41 |
Hyperplasia, Lymphoid | 2 4 | 2 3.0|
Infiltration Cellular, Plasma Cell | 3 | 6 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + M + | 44 |
Congestion | | 4 2.0|
Hyperplasia, Lymphoid | 4 | 2 3.5|
Infiltration Cellular, Plasma Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Acute | | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + | 49 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 | 31 2.8|
Hyperplasia, Lymphoid | 3 4 3 | 11 2.7|
__________________________________________________________________________|____________|
Thymus | + + M M M + M M + | 23 |
Hyperplasia, Lymphoid | 3 | 2 2.0|
Infiltration Cellular, Plasma Cell | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3| | |
| 3| 3| 3| 5| 7| 3| 3| 3| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + + M M + | 25 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Hydrocephalus | | 1 3.0|
Mineralization, Focal | 2 2 2 2 2 1 2 | 24 1.7|
Artery, Inflammation, Chronic | 3 | 1 3.0|
Choroid Plexus, Inflammation, | | |
Chronic, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | | 1 2.0|
Hemorrhage, Focal | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Perivascular, Inflammation, Chronic | 2 1 2 2 1 3 | 33 2.1|
Pleura, Inflammation, Acute | | 2 3.5|
Pleura, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + A + | 47 |
Inflammation, Chronic | 2 2 | 4 1.8|
Metaplasia, Squamous | 2 2 2 | 18 2.1|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 2 2 | 28 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 1| 5| 3| 3| 3| 2| 3| | |
| 3| 3| 3| 5| 7| 3| 3| 3| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + A + | 49 |
Congestion | | 3 1.7|
Glomerulosclerosis | 3 4 3 | 13 3.3|
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Chronic, Focal | 2 3 3 3 | 25 2.2|
Artery, Inflammation, Chronic | 2 | 1 2.0|
Cortex, Necrosis, Focal | | 1 2.0|
Renal Tubule, Regeneration | | 6 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + | 49 |
Inflammation, Chronic, Focal | 1 2 2 2 2 2 | 37 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 4| 5| 3| 3| 5| 5| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 3| 1|
| 1| 1| 1| 7| 7| 1| 8| 1| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + M M M M + + M + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + +|
Artery, Inflammation | 4 |
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + M + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Fatty Change | 1 2|
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | 3 |
Mixed Cell Focus | |
Necrosis, Focal | 3 2 1 |
Artery, Mineralization | 4 |
Perivascular, Inflammation, Chronic | 3 3 |
__________________________________________________________________________|
Mesentery | +|
Hemorrhage | |
Inflammation, Acute | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 |
Acinus, Atrophy | 4 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic, Focal | 2 2 3 2 1 2 2 1 2 3 1 2 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 |
__________________________________________________________________________|
Tooth | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 4| 5| 3| 3| 5| 5| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 3| 1|
| 1| 1| 1| 7| 7| 1| 8| 1| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Acute | 4 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Congestion | 1|
Cyst | X |
Cytoplasmic Alteration, Focal | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + M M + + + + + + M M M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + M + + M + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 |
Inflammation, Chronic, Focal | 1 1 |
Inflammation, Chronic | |
Follicular Cell, Hyperplasia, Focal | 1 1 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 |
Congestion | |
Cyst | X X X X X X X X |
Follicle, Hemorrhage | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2|
Dilatation | |
Inflammation, Acute | 3 |
Endometrium, Hyperplasia, Cystic | 2 3 3 3 3 2 4 2 3 3 4 4 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 4 2 3|
Myelofibrosis | 2 3 2 2 3 2 2 3 3 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 4| 5| 3| 3| 5| 5| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 3| 1|
| 1| 1| 1| 7| 7| 1| 8| 1| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + M + + + + + + + + + + + + + + + + M + +|
Lumbar, Congestion | |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 4 |
Lumbar, Inflammation, Acute | |
Mediastinal, Congestion | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 4 4 |
Pancreatic, Infiltration Cellular, | |
Plasma Cell | |
Renal, Congestion | |
Renal, Infiltration Cellular, Plasma | |
Cell | 4 4 |
Renal, Necrosis | |
Renal, Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M A + + M M + + M + + + + M M M +|
Congestion | 2 |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Plasma Cell | 2 2 2 3|
Inflammation, Acute | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + A + + + + + + + + + + + + M + +|
Congestion | |
Hemorrhage | |
Infiltration Cellular, Plasma Cell | 4 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 4 4 3 4 2 3 2 2 4 1 2 3 2 4|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 3 4 3 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + M + A + M + M M + + M + + + + M I +|
Infiltration Cellular, Plasma Cell | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M + + M M M M M + M M M M M + +|
__________________________________________________________________________|
Skin | + + + M + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Sternum, Necrosis | |
Tarsal, Hyperostosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 4| 5| 3| 3| 5| 5| 4| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 3| 3| 3| 3| 1|
| 1| 1| 1| 7| 7| 1| 8| 1| 8| 9| 2| 2| 2| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage, Focal | 3 |
Hydrocephalus | |
Hyperplasia, Lymphoid | 3 |
Mineralization, Focal | 2 2 2 1 2 1 2 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Giant Cell | 2 |
Granuloma | 2 1 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute, Focal | |
Perivascular, Inflammation, Chronic | 3 2 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic | |
Metaplasia, Squamous | 2 2 2 4 2 2 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + A + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Glomerulosclerosis | 4 4 4 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Plasma Cell | 3 |
Inflammation, Chronic, Focal | 3 2 1 3 2 1 2 |
Cortex, Necrosis, Focal | |
Interstitial Tissue, Inflammation | |
Papilla, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 2 3 2 2 3 2 2 2 3 2 3 1 |
Transitional Epithelium, Hyperplasia,| |
Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 6| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 9| 9| 7| 6| 3| 3|
| 2| 2| 2| 4| 7| 2| 2| 1| 8| 6| 2| 2| 2| 2| 4| 2| 2| 2| 0| 9| 1| 8| 7| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
0.06% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + M + + + + + + M M M + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + A + + M A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + A + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + M A + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + A + + + M A + + + A +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + A + + + A +|
Artery, Inflammation | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + M + A + + + A + + M + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + M A A + + + A +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + M + + A + + + A A + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change | 2 |
Hematopoietic Cell Proliferation | 4 3|
Hyperplasia, Lymphoid | |
Mixed Cell Focus | |
Necrosis, Focal | |
Artery, Mineralization | |
Perivascular, Inflammation, Chronic | 2 1 2 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | 3 |
Inflammation, Acute | 4 |
Fat, Necrosis | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + M + + + + + + + + M +|
Inflammation, Chronic, Focal | 2 2 3 2 2 2 2 2|
Acinus, Atrophy | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 2 2 3 3 2 3 3 2 2 1 2 2 3 2 3|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + M +|
Hyperkeratosis | 2 3 |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + A + + + M +|
Inflammation, Chronic | 1 1 1 2 1 |
__________________________________________________________________________|
Tooth | + |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 6| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 9| 9| 7| 6| 3| 3|
| 2| 2| 2| 4| 7| 2| 2| 1| 8| 6| 2| 2| 2| 2| 4| 2| 2| 2| 0| 9| 1| 8| 7| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
0.06% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Acute | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + M + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + M + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | |
Cyst | |
Cytoplasmic Alteration, Focal | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + + I|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + M +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + M + M M + M M + M + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + M + + + M + I +|
Pars Distalis, Hyperplasia, Focal | 4 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 1 1 |
Inflammation, Chronic | 1 1 |
Follicular Cell, Hyperplasia, Focal | 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + + + + + + +|
Abscess | 4 4 4 4 4 4|
Congestion | 2 |
Cyst | X X X X X X X X X X X X |
Follicle, Hemorrhage | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Dilatation | |
Inflammation, Acute | 4 2 4 2 |
Endometrium, Hyperplasia, Cystic | 3 3 2 3 2 1 2 3 1 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia, Neutrophil | 4 3 2 2 1 3|
Myelofibrosis | 3 2 2 2 2 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 6| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 9| 9| 7| 6| 3| 3|
| 2| 2| 2| 4| 7| 2| 2| 1| 8| 6| 2| 2| 2| 2| 4| 2| 2| 2| 0| 9| 1| 8| 7| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
0.06% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + M + + + + + + + + + + + + + +|
Lumbar, Congestion | 4 4 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 4|
Lumbar, Inflammation, Acute | 3 |
Mediastinal, Congestion | 3 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 4 3 4|
Pancreatic, Infiltration Cellular, | |
Plasma Cell | 4 |
Renal, Congestion | 4 4 |
Renal, Infiltration Cellular, Plasma | |
Cell | 4|
Renal, Necrosis | 3 |
Renal, Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + M M + M M M M + M + + M + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 |
Infiltration Cellular, Plasma Cell | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M M + + + + + + + + + + + + + +|
Congestion | 4 |
Hemorrhage | 3 |
Infiltration Cellular, Plasma Cell | 4|
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 4 2 3 2 2 2 2 4 3 4 3 4 4|
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 3 2 3 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + M + + + M + M M M + + + + + M M + + M + M +|
Infiltration Cellular, Plasma Cell | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M + + + + M M M + M M M M + M + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Necrosis | 2 |
Tarsal, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 6| 5| 3| 3| 3| 3| 3| 1| 3| 3| 3| 8| 9| 9| 7| 6| 3| 3|
| 2| 2| 2| 4| 7| 2| 2| 1| 8| 6| 2| 2| 2| 2| 4| 2| 2| 2| 0| 9| 1| 8| 7| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
0.06% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage, Focal | |
Hydrocephalus | |
Hyperplasia, Lymphoid | |
Mineralization, Focal | 2 2 1 2 2 2 1 2 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Giant Cell | |
Granuloma | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Acute, Focal | 2 |
Perivascular, Inflammation, Chronic | 2 2 2 2 1 1 2 2 1 2 1 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + M M + + + + + + + M + +|
Inflammation, Chronic | 2 |
Metaplasia, Squamous | 2 3 3 2 2 3 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Glomerulosclerosis | 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | |
Inflammation, Chronic, Focal | 2 2 2 1 2 2 2 2 1 1 1 2 2|
Cortex, Necrosis, Focal | 3 1 |
Interstitial Tissue, Inflammation | 3 |
Papilla, Necrosis | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + M + + + + A + + + + A +|
Inflammation, Chronic, Focal | 2 1 3 1 3 2 3 3 2 2 1 2 2 |
Transitional Epithelium, Hyperplasia,| |
Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 6| 5| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5| | |
| 2| 2| 2| 8| 7| 2| 1| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 39 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 44 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 46 |
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 43 |
Amyloid Deposition | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + M M + | 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Fatty Change | 1 | 4 1.5|
Hematopoietic Cell Proliferation | | 3 3.7|
Hyperplasia, Lymphoid | | 1 3.0|
Mixed Cell Focus | 2 | 1 2.0|
Necrosis, Focal | | 3 2.0|
Artery, Mineralization | | 1 4.0|
Perivascular, Inflammation, Chronic | 3 | 9 1.9|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Hemorrhage | | 1 3.0|
Inflammation, Acute | | 1 4.0|
Fat, Necrosis | | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 48 |
Inflammation, Chronic, Focal | 2 2 | 17 2.1|
Acinus, Atrophy | | 1 4.0|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 49 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic, Focal | 3 2 2 | 32 2.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 49 |
Hyperkeratosis | | 2 2.5|
Hyperplasia, Squamous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 47 |
Inflammation, Chronic | 2 | 9 1.6|
__________________________________________________________________________|____________|
Tooth | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 6| 5| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5| | |
| 2| 2| 2| 8| 7| 2| 1| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Cardiomyopathy | | 1 2.0|
Inflammation, Acute | | 1 4.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 49 |
Capsule, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 49 |
Atrophy | | 2 2.0|
Congestion | | 1 1.0|
Cyst | | 1 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 46 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 47 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M | 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + | 43 |
Pars Distalis, Hyperplasia, Focal | 4 | 6 3.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
Inflammation, Acute, Focal | | 1 1.0|
Inflammation, Chronic, Focal | 2 | 5 1.2|
Inflammation, Chronic | | 2 1.0|
Follicular Cell, Hyperplasia, Focal | 4 | 8 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + | 49 |
Abscess | | 8 4.0|
Congestion | 1 | 2 1.5|
Cyst | | 20 |
Follicle, Hemorrhage | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 6| 5| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5| | |
| 2| 2| 2| 8| 7| 2| 1| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + | 50 |
Atrophy | | 1 2.0|
Dilatation | 3 | 1 3.0|
Inflammation, Acute | | 5 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 3 2 2 | 33 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 49 |
Hyperplasia, Neutrophil | 3 | 10 2.7|
Myelofibrosis | 3 3 3 | 27 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 47 |
Lumbar, Congestion | | 2 4.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 2 4.0|
Lumbar, Inflammation, Acute | | 1 3.0|
Mediastinal, Congestion | | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 5 3.8|
Pancreatic, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
Renal, Congestion | | 2 4.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 3 4.0|
Renal, Necrosis | | 1 3.0|
Renal, Lymphatic, Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + M + | 26 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Infiltration Cellular, Plasma Cell | 4 | 6 2.5|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 45 |
Congestion | 2 | 2 3.0|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Plasma Cell | | 2 4.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Hematopoietic Cell Proliferation | 3 1 2 2 | 37 2.7|
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | | 8 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 6| 5| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5| | |
| 2| 2| 2| 8| 7| 2| 1| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M M + M + | 30 |
Infiltration Cellular, Plasma Cell | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + + + | 20 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + M + | 49 |
Sternum, Necrosis | | 1 2.0|
Tarsal, Hyperostosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Hemorrhage, Focal | | 1 3.0|
Hydrocephalus | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Mineralization, Focal | 2 2 2 2 2 | 31 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Congestion | | 1 2.0|
Giant Cell | | 1 2.0|
Granuloma | | 2 1.5|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Acute, Focal | | 1 2.0|
Perivascular, Inflammation, Chronic | 2 3 | 27 1.9|
__________________________________________________________________________|____________|
Nose | M + + + M + | 44 |
Inflammation, Chronic | | 1 2.0|
Metaplasia, Squamous | 2 3 | 15 2.4|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 | 30 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 6| 5| 4| 4| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 6| 4| 5| 5| | |
| 2| 2| 2| 8| 7| 2| 1| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Degeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 49 |
Atrophy, Focal | | 1 2.0|
Glomerulosclerosis | 4 | 5 3.8|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Plasma Cell | | 1 3.0|
Inflammation, Chronic, Focal | 3 2 | 22 1.9|
Cortex, Necrosis, Focal | | 2 2.0|
Interstitial Tissue, Inflammation | | 1 3.0|
Papilla, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + | 46 |
Inflammation, Chronic, Focal | 3 2 2 1 | 30 2.2|
Transitional Epithelium, Hyperplasia,| | |
Focal | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 4| 7| 6| 6| 4| 4| 5| 5| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 5| 4| 3| 3| 1| 8| 5| 2| 8| 3| 5| 5| 4| 3| 1| 5| 5|
| 1| 1| 1| 1| 0| 1| 2| 1| 7| 2| 1| 1| 6| 8| 8| 6| 4| 9| 8| 7| 9| 4| 6| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + M + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + M + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Cytoplasmic Alteration, Focal | 3 |
Fatty Change | 3 |
Hematopoietic Cell Proliferation | 2 4 2 |
Hyperplasia, Lymphoid | |
Necrosis, Focal | 1 |
Centrilobular, Necrosis | 4 |
Periductular, Fibrosis | 1 |
Perivascular, Inflammation, Chronic | 2 2 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Acute | 3 2 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + M + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
Hypoplasia | |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 3 2 2 2 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | X |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 2 |
Mineralization, Focal | 1 |
Artery, Inflammation | |
__________________________________________________________________________|
Tooth | + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 4| 7| 6| 6| 4| 4| 5| 5| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 5| 4| 3| 3| 1| 8| 5| 2| 8| 3| 5| 5| 4| 3| 1| 5| 5|
| 1| 1| 1| 1| 0| 1| 2| 1| 7| 2| 1| 1| 6| 8| 8| 6| 4| 9| 8| 7| 9| 4| 6| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + M + M + + + + + + M + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + M + M + + + + + + M + + + + |
Congestion | |
Hematopoietic Cell Proliferation | 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + M + + + + + + M I + + + |
Congestion | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + M M M M M + + M M M + M + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 4 2 1 2 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | |
Follicular Cell, Hyperplasia, Focal | 2 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | I + + + + + + + + + + + + + + + + + + |
Abscess | 4 4 4 4 4 |
Cyst | X X X X X |
Inflammation, Acute | 4 |
Inflammation, Chronic | 3 |
Thrombosis | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Abscess | |
Dilatation | |
Inflammation, Acute | 3 3 |
Thrombosis | |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 2 4 3 3 2 1 3 3 4 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + M + + |
Angiectasis | |
Hyperplasia, Neutrophil | 2 2 4 3 2 4 |
Myelofibrosis | 2 3 1 3 2 3 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Axillary, Hyperplasia, Lymphoid | 2 |
Lumbar, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 4| 7| 6| 6| 4| 4| 5| 5| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 5| 4| 3| 3| 1| 8| 5| 2| 8| 3| 5| 5| 4| 3| 1| 5| 5|
| 1| 1| 1| 1| 0| 1| 2| 1| 7| 2| 1| 1| 6| 8| 8| 6| 4| 9| 8| 7| 9| 4| 6| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Plasma Cell | 4 |
Lymphatic, Angiectasis | |
Mediastinal, Abscess | 4 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 4 4 |
Renal, Infiltration Cellular, Plasma | |
Cell | 4 4 |
Renal, Lymphatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + + + + M + M M + + M + M + + |
Infiltration Cellular, Plasma Cell | 2 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + |
Congestion | 4 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 2 4 1 2 3 2 4 4 3 4 4 4 3 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Acute | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + M + M M + + + + + M M + M M + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M + + + M + + M M + M M + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hydrocephalus | 2 |
Mineralization, Focal | 2 1 1 1 2 2 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Hemorrhage, Focal | |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Metaplasia | |
Perivascular, Inflammation, Chronic | 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 4| 7| 6| 6| 4| 4| 5| 5| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 5| 4| 3| 3| 1| 8| 5| 2| 8| 3| 5| 5| 4| 3| 1| 5| 5|
| 1| 1| 1| 1| 0| 1| 2| 1| 7| 2| 1| 1| 6| 8| 8| 6| 4| 9| 8| 7| 9| 4| 6| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + M + + + M + + M + + + + + + + |
Inflammation, Chronic | 2 2 2 |
Metaplasia, Squamous | 3 3 2 3 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation, Chronic | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Atrophy, Focal | |
Glomerulosclerosis | 4 4 4 2 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 1 2 1 2 2 3 2 2 |
Mineralization | |
Cortex, Necrosis, Focal | 4 |
Renal Tubule, Pigmentation | 3 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + M + + + + + + |
Inflammation, Chronic, Focal | 2 2 2 2 2 1 1 2 3 3 1 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 0| 5| 3| 5| 0| 4| 5| 3| 3| 3| 5| 1| 3| 3| 3| 8| 5| 3| 3| 0| 8| 5|
| 1| 1| 1| 5| 1| 1| 9| 7| 0| 7| 1| 1| 1| 9| 4| 1| 1| 1| 0| 8| 1| 1| 1| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.3% MF | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + M + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + M + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M + + + |
Amyloid Deposition | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Cytoplasmic Alteration, Focal | |
Fatty Change | 2 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
Necrosis, Focal | 1 1 1 2 |
Centrilobular, Necrosis | |
Periductular, Fibrosis | |
Perivascular, Inflammation, Chronic | 1 2 2 3 1 2 1 2 2 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Acute | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 2 2 2 1 2 1 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + |
Hypoplasia | 2 |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + + + |
Cyst Epithelial Inclusion | |
Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 2 |
Mineralization, Focal | 2 |
Artery, Inflammation | 2 |
__________________________________________________________________________|
Tooth | |
Abscess | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 0| 5| 3| 5| 0| 4| 5| 3| 3| 3| 5| 1| 3| 3| 3| 8| 5| 3| 3| 0| 8| 5|
| 1| 1| 1| 5| 1| 1| 9| 7| 0| 7| 1| 1| 1| 9| 4| 1| 1| 1| 0| 8| 1| 1| 1| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.3% MF | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + M + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + M + + + + + + + |
Congestion | |
Hematopoietic Cell Proliferation | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + + + + + + |
Congestion | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + M + + + + + + + + M + M + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M M + + M M + M + + M M M + + M M + + + M M |
__________________________________________________________________________|
Pituitary Gland | + M + M + M M + + + + + + + M + M + + + + + |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 4 3 3 3 |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 1 2 |
Follicular Cell, Hyperplasia, Focal | 2 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 |
Cyst | X X X X X X |
Inflammation, Acute | |
Inflammation, Chronic | |
Thrombosis | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + |
Abscess | |
Dilatation | 4 |
Inflammation, Acute | |
Thrombosis | |
Endometrium, Cyst | X |
Endometrium, Hyperplasia, Cystic | 3 3 3 2 3 2 4 3 3 3 3 2 1 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Hyperplasia, Neutrophil | 2 2 3 |
Myelofibrosis | 2 2 3 1 1 2 2 2 3 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Axillary, Hyperplasia, Lymphoid | |
Lumbar, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 0| 5| 3| 5| 0| 4| 5| 3| 3| 3| 5| 1| 3| 3| 3| 8| 5| 3| 3| 0| 8| 5|
| 1| 1| 1| 5| 1| 1| 9| 7| 0| 7| 1| 1| 1| 9| 4| 1| 1| 1| 0| 8| 1| 1| 1| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.3% MF | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Plasma Cell | |
Lymphatic, Angiectasis | |
Mediastinal, Abscess | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Renal, Infiltration Cellular, Plasma | |
Cell | |
Renal, Lymphatic, Angiectasis | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + + M M M M M M M + + + + + + + |
Infiltration Cellular, Plasma Cell | 2 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 4 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 3 3 |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 4 2 2 2 2 3 2 2 2 4 |
Hyperplasia, Lymphoid | 3 4 4 4 |
Inflammation, Acute | |
Pigmentation, Hemosiderin | 3 2 |
__________________________________________________________________________|
Thymus | M + M + + M + M + + M + + M + + + + + + M M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M + M M + + M M + + M M + + M M + M + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + M + + + + + + + + |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hydrocephalus | |
Mineralization, Focal | 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hemorrhage, Focal | 2 |
Infiltration Cellular, Histiocyte | 3 |
Alveolar Epithelium, Metaplasia | |
Perivascular, Inflammation, Chronic | 2 1 2 2 2 2 2 2 2 3 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 6| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 0| 5| 3| 5| 0| 4| 5| 3| 3| 3| 5| 1| 3| 3| 3| 8| 5| 3| 3| 0| 8| 5|
| 1| 1| 1| 5| 1| 1| 9| 7| 0| 7| 1| 1| 1| 9| 4| 1| 1| 1| 0| 8| 1| 1| 1| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.3% MF | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + M + + + M + + + |
Inflammation, Chronic | 3 |
Metaplasia, Squamous | 2 2 2 4 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + + + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Atrophy, Focal | 1 |
Glomerulosclerosis | 2 3 3 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic, Focal | 1 1 2 1 2 2 2 2 2 2 2 2 3 2 2 |
Mineralization | 2 |
Cortex, Necrosis, Focal | |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 2 2 1 1 1 2 1 2 2 2 2 2 2 1 2 2 4 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 0| 0| 0| 0| | |
DAY ON TEST | 3| 3| 3| 3| 5| 5| 0| 0| 0| 0| | |
| 1| 1| 1| 1| 7| 1| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A A A M | 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + M + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + + A + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + M | 48 |
Amyloid Deposition | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A A A + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Cytoplasmic Alteration, Focal | | 1 3.0|
Fatty Change | 1 | 4 2.0|
Hematopoietic Cell Proliferation | 2 3 | 5 2.6|
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis, Focal | 2 | 6 1.3|
Centrilobular, Necrosis | | 1 4.0|
Periductular, Fibrosis | | 1 1.0|
Perivascular, Inflammation, Chronic | 2 | 13 1.8|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Inflammation, Acute | | 2 2.5|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + M M + + + + + | 47 |
Inflammation, Chronic, Focal | 2 2 | 14 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Hypoplasia | | 1 2.0|
Inflammation, Chronic, Focal | 2 2 2 2 | 29 2.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 49 |
Cyst Epithelial Inclusion | | 1 |
Hyperplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 2 | 6 1.8|
Mineralization, Focal | | 2 1.5|
Artery, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Abscess | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 0| 0| 0| 0| | |
DAY ON TEST | 3| 3| 3| 3| 5| 5| 0| 0| 0| 0| | |
| 1| 1| 1| 1| 7| 1| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 46 |
Congestion | 3 3 | 2 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 45 |
Congestion | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + M M + + + + + | 43 |
Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + + | 26 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + | 42 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | 2 3 2 | 13 2.5|
Pars Distalis, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Inflammation, Chronic, Focal | | 2 1.5|
Follicular Cell, Hyperplasia, Focal | 2 | 11 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 49 |
Abscess | 4 3 | 8 3.9|
Cyst | X | 12 |
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Thrombosis | | 2 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Abscess | 3 3 | 2 3.0|
Dilatation | | 1 4.0|
Inflammation, Acute | 2 | 3 2.7|
Thrombosis | X | 1 |
Endometrium, Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 0| 0| 0| 0| | |
DAY ON TEST | 3| 3| 3| 3| 5| 5| 0| 0| 0| 0| | |
| 1| 1| 1| 1| 7| 1| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic | 1 3 2 3 3 | 35 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 49 |
Angiectasis | 3 | 1 3.0|
Hyperplasia, Neutrophil | 3 2 3 2 | 13 2.6|
Myelofibrosis | 2 | 21 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + M | 49 |
Axillary, Hyperplasia, Lymphoid | | 1 2.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
Lymphatic, Angiectasis | 4 | 1 4.0|
Mediastinal, Abscess | | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 2 4.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | 4 | 3 4.0|
Renal, Lymphatic, Angiectasis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + M M + + M M | 29 |
Infiltration Cellular, Plasma Cell | 2 | 7 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + A M + M | 45 |
Congestion | | 3 3.3|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 3 2.7|
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 3 2 3 3 | 32 2.7|
Hyperplasia, Lymphoid | | 5 3.6|
Inflammation, Acute | 4 | 1 4.0|
Pigmentation, Hemosiderin | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Thymus | + + M M + M + M M | 30 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + M + + M + + | 28 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 49 |
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 5| 0| 0| 0| 0| | |
DAY ON TEST | 3| 3| 3| 3| 5| 5| 0| 0| 0| 0| | |
| 1| 1| 1| 1| 7| 1| 9| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Congestion | 3 3 | 2 3.0|
Hydrocephalus | | 1 2.0|
Mineralization, Focal | 1 2 1 | 28 1.8|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | 4 4 4 4 | 5 3.6|
Hemorrhage, Focal | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 2 2.5|
Alveolar Epithelium, Metaplasia | 2 | 1 2.0|
Perivascular, Inflammation, Chronic | 3 2 | 22 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 45 |
Inflammation, Chronic | 2 | 5 2.2|
Metaplasia, Squamous | 2 2 | 10 2.5|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 2 | 27 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 6 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Atrophy, Focal | | 1 1.0|
Glomerulosclerosis | 3 | 8 3.1|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic, Focal | 3 3 2 | 26 2.0|
Mineralization | | 1 2.0|
Cortex, Necrosis, Focal | | 1 4.0|
Renal Tubule, Pigmentation | | 1 3.0|
Renal Tubule, Regeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A A A A | 44 |
Inflammation, Chronic, Focal | 2 2 2 1 | 35 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 5| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3|
| 0| 0| 0| 8| 8| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 1| 1| 2| 0| 0| 1| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + M + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + A M + + + + + + + + + M|
Degeneration, Hyaline | |
Inflammation, Chronic, Focal | 2 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + A + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + M + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + A + + + + + + + + + +|
Eosinophilic Focus | 3 |
Fatty Change | |
Hematopoietic Cell Proliferation | 3 4 |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Inflammation, Focal, Granulomatous | 3 |
Mixed Cell Focus | |
Necrosis, Focal | 1 1 1 1 1 |
Hepatocyte, Hyperplasia, Focal | |
Perivascular, Inflammation, Chronic | 2 1 1 1 2 2 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 1 1 2 2 3 2 1 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 1 2 2 2 1 2 1 1 2 2 3 3 |
__________________________________________________________________________|
Stomach | + M + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + M + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + M + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tooth | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 5| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3|
| 0| 0| 0| 8| 8| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 1| 1| 2| 0| 0| 1| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization, Focal | |
Coronary Artery, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + A + + + + + + + + + +|
Capsule, Hyperplasia | |
Subcapsular, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + A + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Angiectasis | 3 |
Congestion | 2 |
Cytoplasmic Alteration, Focal | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + A + + + + + + M + + M|
Congestion | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + M + + + M + + M + M M M + + +|
__________________________________________________________________________|
Pituitary Gland | M + + M + + + + + + + + + + + + + + M + + + +|
Congestion | 1 |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 1 4 2 4 3 3 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1|
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia, Focal | 2 2 2 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 |
Congestion | |
Cyst | X X X X X|
Hemorrhage | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Dilatation | 4 4 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 5| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3|
| 0| 0| 0| 8| 8| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 1| 1| 2| 0| 0| 1| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 3 4 1 1 4 3 4 2 3 3 3 2 2 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Neutrophil | 3 |
Myelofibrosis | 2 2 2 1 2 2 2 2 3 2 2 2 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + M + + + + + + + + + + + + +|
Mediastinal, Abscess | |
Renal, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + I + + + + + M + M + M + + + + + + + M +|
Congestion | 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + M M + + + + + + M + + +|
Amyloid Deposition | |
Congestion | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + A + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 3 2 4 2 2 3 |
Hyperplasia, Lymphoid | 2 4 2 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + M + M + + + M + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + M + M M M + + M M + + + + M M M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 1 2 1 1 2 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Alveolar Epithelium, Metaplasia | |
Perivascular, Inflammation, Chronic | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1|
Pleura, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 2| 2| 5| 3| 3| 3| 3| 3| 3| 3| 6| 4| 3|
| 0| 0| 0| 8| 8| 0| 0| 0| 0| 0| 0| 0| 0| 2| 1| 0| 0| 1| 1| 2| 0| 0| 1| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | M + + + + + + + M + M + + + + + + + + + + + +|
Metaplasia, Squamous | 2 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + + + + + +|
Congestion | |
Glomerulosclerosis | 3 3 2 3 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 2 2 2 2|
Cortex, Degeneration | |
Cortex, Necrosis, Focal | |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A A + + + A + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3|
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 6| 8| 7| 0| 0| 0| 0| 6| 1| 1| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% HF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + + + + +|
Degeneration, Hyaline | 2 |
Inflammation, Chronic, Focal | |
Serosa, Inflammation, Chronic | 2|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | |
Fatty Change | 2 1 2 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Acute | 4|
Inflammation, Focal, Granulomatous | |
Mixed Cell Focus | 2 |
Necrosis, Focal | 1 1 1 |
Hepatocyte, Hyperplasia, Focal | |
Perivascular, Inflammation, Chronic | 2 1 2 2 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 1 2 |
Artery, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
Inflammation, Chronic, Focal | 2 2 2 1 2 3 2 2 1 1 3 2 3 1 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 2 |
__________________________________________________________________________|
Tooth | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 6| 8| 7| 0| 0| 0| 0| 6| 1| 1| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% HF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization, Focal | 1 |
Coronary Artery, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 4 |
Subcapsular, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | |
Congestion | |
Cytoplasmic Alteration, Focal | 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M I M + + M M + + + M M + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + I + + + + M + + + + + + + + + + + +|
Congestion | |
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Hyperplasia, Focal | 2 2 3 4 3 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + I + + + + + + + +|
Inflammation, Chronic, Focal | 3 2 1 3 2 |
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia, Focal | 4 2 1 3 1 2 2 4 3 4 3 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4|
Congestion | |
Cyst | X X X X X |
Hemorrhage | 3 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Dilatation | 3 4 4 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 6| 8| 7| 0| 0| 0| 0| 6| 1| 1| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% HF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 3 4 3 3 3 2 2 3 3 4 4 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Neutrophil | 2|
Myelofibrosis | 2 1 3 2 2 2 3 2 3 2 3 2 1 3 1 3 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Abscess | 3|
Renal, Infiltration Cellular, Plasma | |
Cell | 4|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Plasma Cell | 2 2 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M + + + + + + + + + + + + + + + + + + + M|
Amyloid Deposition | 3 |
Congestion | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 1 2 2 2 2 2 2 4 2 2 2 2 4|
Hyperplasia, Lymphoid | 3 2 2 4 |
__________________________________________________________________________|
Thymus | M M + M M M M + + + M + + M + + M + M M + +|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M + M M M + + M M M M +|
__________________________________________________________________________|
Skin | + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 2 1 2 2 2 2 2 2 1 2 2 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Alveolar Epithelium, Metaplasia | 2 |
Perivascular, Inflammation, Chronic | 3 2 2 3 2 2 2 2 2 2 2 2 2 2 1 1 |
Pleura, Inflammation, Acute | 2|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 9| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0| 6| 8| 7| 0| 0| 0| 0| 6| 1| 1| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% HF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + M + + M + + M M M + + + + M + + + + + M M|
Metaplasia, Squamous | 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 2 2 1 2 2 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Glomerulosclerosis | 3 3 3|
Hyperplasia, Lymphoid | 3 3 |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 1 2 3 2 2 2 |
Cortex, Degeneration | 4 |
Cortex, Necrosis, Focal | 3 |
Renal Tubule, Regeneration | 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Chronic, Focal | 3 2 2 1 2 2 2 2 1 2 3 3 2 2 2 2 2 2 |
Artery, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 4| 4| 4| | |
DAY ON TEST | 3| 3| 9| 5| 5| 3| 3| 5| 5| 5| | |
| 2| 1| 3| 8| 8| 1| 1| 8| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M M + | 45 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 46 |
Degeneration, Hyaline | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
Serosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 48 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 48 |
Amyloid Deposition | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + | 49 |
Eosinophilic Focus | | 1 3.0|
Fatty Change | | 3 1.7|
Hematopoietic Cell Proliferation | 3 2 | 5 3.2|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Acute | | 1 4.0|
Inflammation, Focal, Granulomatous | | 1 3.0|
Mixed Cell Focus | | 1 2.0|
Necrosis, Focal | 1 | 9 1.0|
Hepatocyte, Hyperplasia, Focal | 3 | 1 3.0|
Perivascular, Inflammation, Chronic | | 12 1.6|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 49 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic, Focal | 1 2 2 | 19 1.8|
Artery, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 50 |
Hyperplasia, Lymphoid | | 2 3.0|
Inflammation, Chronic, Focal | 2 2 2 | 31 1.9|
__________________________________________________________________________|____________|
Stomach | + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 48 |
Inflammation, Chronic | | 5 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 4| 4| 4| | |
DAY ON TEST | 3| 3| 9| 5| 5| 3| 3| 5| 5| 5| | |
| 2| 1| 3| 8| 8| 1| 1| 8| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Acute | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 50 |
Mineralization, Focal | | 1 1.0|
Coronary Artery, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 49 |
Capsule, Hyperplasia | | 1 4.0|
Subcapsular, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 49 |
Accessory Adrenal Cortical Nodule | | 1 |
Angiectasis | | 1 3.0|
Congestion | | 1 2.0|
Cytoplasmic Alteration, Focal | | 1 3.0|
Vacuolization Cytoplasmic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 47 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 49 |
Hyperplasia | | 6 1.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M M | 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 45 |
Congestion | | 1 1.0|
Pars Distalis, Angiectasis | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | | 13 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
Inflammation, Chronic, Focal | 2 1 2 1 1 | 11 1.7|
Follicular Cell, Cyst | X | 1 |
Follicular Cell, Hyperplasia, Focal | 4 4 4 | 25 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 4| 4| 4| | |
DAY ON TEST | 3| 3| 9| 5| 5| 3| 3| 5| 5| 5| | |
| 2| 1| 3| 8| 8| 1| 1| 8| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + | 50 |
Abscess | | 3 4.0|
Congestion | 1 | 1 1.0|
Cyst | | 10 |
Hemorrhage | | 1 3.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + M | 49 |
Angiectasis | | 1 4.0|
Dilatation | | 5 3.8|
Inflammation, Acute | | 1 3.0|
Thrombosis | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 3 | 31 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 49 |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Neutrophil | | 2 2.5|
Myelofibrosis | 2 3 2 2 | 35 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 49 |
Mediastinal, Abscess | | 1 3.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 44 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Plasma Cell | 3 | 9 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 43 |
Amyloid Deposition | | 1 3.0|
Congestion | 4 | 2 3.5|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 49 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | 2 3 2 2 2 | 36 2.2|
Hyperplasia, Lymphoid | 3 | 8 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + M | 34 |
Congestion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 4| 4| 4| | |
DAY ON TEST | 3| 3| 9| 5| 5| 3| 3| 5| 5| 5| | |
| 2| 1| 3| 8| 8| 1| 1| 8| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 50 |
Mineralization, Focal | 1 2 | 31 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 50 |
Congestion | | 1 2.0|
Alveolar Epithelium, Metaplasia | | 1 2.0|
Perivascular, Inflammation, Chronic | 2 | 32 1.9|
Pleura, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + M | 38 |
Metaplasia, Squamous | 2 | 6 2.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 | 22 2.0|
__________________________________________________________________________|____________|
Trachea | + + + M + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 49 |
Congestion | | 1 2.0|
Glomerulosclerosis | 3 | 8 2.9|
Hyperplasia, Lymphoid | | 2 3.0|
Inflammation, Chronic, Focal | 2 3 1 | 26 2.0|
Cortex, Degeneration | | 1 4.0|
Cortex, Necrosis, Focal | | 1 3.0|
Renal Tubule, Regeneration | | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 46 |
Inflammation, Chronic, Focal | 2 2 2 | 36 2.1|
Artery, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|
| 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + A + M|
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Abscess, Multiple | 4 |
Fatty Change | 3 |
Hematopoietic Cell Proliferation | 4 |
Hepatodiaphragmatic Nodule | X |
Mineralization, Focal | |
Necrosis, Focal | 1 |
Hepatocyte, Hyperplasia, Focal | 2 |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 2 |
Acinus, Atrophy | 1 |
Acinus, Hyperplasia | |
Periductular, Inflammation, Acute | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Inflammation, Chronic, Focal | 2 2 2 1 2 2 2 2 1 2 2 1 3 2 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst | |
Hyperkeratosis | 3 |
Hyperplasia, Squamous | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|
| 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | |
Abscess | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + I + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 4 4 |
__________________________________________________________________________|
Parathyroid Gland | M + M + M + + + + + + + + M M M + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 1 |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | |
Necrosis | 3 |
__________________________________________________________________________|
Preputial Gland | + + M + + + + + +|
Abscess | 4 |
Ectasia | 4 3 3|
Inflammation, Chronic | 3 2 3 2 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + M + + M + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
Dilatation | 3 3 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|
| 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia, Focal | |
Seminiferous Tubule, Atrophy | 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Hypochromasia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 4 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Infiltration Cellular, | |
Plasma Cell | 4 |
Lumbar, Hyperplasia, Lymphoid | 3 4 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 3 |
Renal, Hyperplasia, Lymphoid | 3 2 |
Renal, Infiltration Cellular, Plasma | |
Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + + + M + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Plasma Cell | 3 2 3 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + M + + + + + + + + M + + + + +|
Congestion | 3 3 2 3 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 3 4 3 4 3 2 2 4 4 |
Hyperplasia, Lymphoid | 4 2 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Thymus | M M M M M M M M M M M M M M M M + M M M M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M + M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + M + + + + + + + +|
Fibrosis | |
Ulcer | 4 2 2 |
Dermis, Inflammation, Chronic | |
Epidermis, Inflammation, Acute | |
Subcutaneous Tissue, Hyperplasia, | |
Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|
| 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
Cranium, Fibrous Osteodystrophy | |
Tarsal, Hyperostosis | 4 4 4 4 4 3 4 4 3 4 3 4 3 3 4 4 3 4 4 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia | 2 |
Perivascular, Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + M + + + + M + + + + + + + + + + + + + M + +|
Inflammation, Chronic | |
Metaplasia, Squamous | 2 2 2 3 2 1 2 3 2 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 3 3 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Glomerulosclerosis | 2 3 |
Hydronephrosis | |
Hyperplasia, Lymphoid | 3 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 2 1 2 2 2 1 1 1 2 2 1 2 |
Mineralization | 1 |
Capsule, Fibrosis | |
Pelvis, Inflammation, Acute | |
Renal Tubule, Regeneration | 1 1 1 3 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + A|
Calculus Gross Observation | |
Concretion | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 6| 6| 7| 7| 5| 4| 2|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 0| 3| 3| 3| 6| 5| 3| 3| 7| 5| 5| 3| 3| 7| 7| 6|
| 6| 6| 6| 6| 9| 6| 6| 7| 7| 3| 6| 6| 6| 3| 7| 6| 7| 1| 4| 4| 6| 6| 8| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 2 3 1 1 1 1 1 2 2 2 1 1 1 2 2 |
Inflammation, Chronic Active | |
Artery, Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|
| 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + M + + M + + M + + + + + M |
Inflammation, Chronic, Focal | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Abscess | |
Abscess, Multiple | |
Fatty Change | 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Mineralization, Focal | 2 |
Necrosis, Focal | 2 3 |
Hepatocyte, Hyperplasia, Focal | |
Perivascular, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + M M + + + + + + |
Inflammation, Chronic, Focal | |
Acinus, Atrophy | 2 1 |
Acinus, Hyperplasia | |
Periductular, Inflammation, Acute | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic, Focal | 1 2 2 1 2 2 1 2 3 2 2 2 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Cyst | X |
Hyperkeratosis | |
Hyperplasia, Squamous | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|
| 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + |
Abscess | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Coronary Artery, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Cytoplasmic Alteration, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M M + + + + + + |
Hyperplasia | 2 3 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M M + + M + + + + M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 1 1 1 |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | 4 |
Necrosis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + |
Abscess | 4 3 4 |
Ectasia | |
Inflammation, Chronic | 4 3 3 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
Inflammation, Acute | 4 |
Inflammation, Chronic | 2 1 1 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + + + + + + + + + |
Atrophy | 1 |
Dilatation | 2 3 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|
| 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + |
Hypospermia, Focal | 3 |
Seminiferous Tubule, Atrophy | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Hypochromasia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Infiltration Cellular, | |
Plasma Cell | |
Lumbar, Hyperplasia, Lymphoid | |
Lumbar, Infiltration Cellular, | |
Plasma Cell | |
Renal, Hyperplasia, Lymphoid | |
Renal, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 2 2 2 2 2 2 2 1 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + |
Congestion | 2 2 2 3 4 2 4 4 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Atrophy | |
Hematopoietic Cell Proliferation | 3 4 4 2 2 3 4 2 |
Hyperplasia, Lymphoid | 3 2 |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Thymus | + M M M + M M M + M + M M M + + M M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + M + |
Fibrosis | |
Ulcer | 3 2 |
Dermis, Inflammation, Chronic | 3 2 |
Epidermis, Inflammation, Acute | 3 |
Subcutaneous Tissue, Hyperplasia, | |
Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|
| 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
Hyperostosis | |
Cranium, Fibrous Osteodystrophy | X |
Tarsal, Hyperostosis | 3 4 4 4 X 4 4 4 4 4 4 4 3 3 4 4 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
Mineralization, Focal | 2 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Congestion | |
Infiltration Cellular, Histiocyte | 4 |
Alveolar Epithelium, Hyperplasia | |
Perivascular, Inflammation, Chronic | 2 2 2 3 2 2 2 2 2 2 2 |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 3 |
Metaplasia, Squamous | 2 4 2 2 3 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 3 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Glomerulosclerosis | 3 3 |
Hydronephrosis | |
Hyperplasia, Lymphoid | 3 |
Inflammation, Acute, Focal | 4 |
Inflammation, Chronic, Focal | 1 1 2 3 2 2 2 2 2 2 1 1 1 |
Mineralization | |
Capsule, Fibrosis | |
Pelvis, Inflammation, Acute | |
Renal Tubule, Regeneration | 1 2 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
Calculus Gross Observation | |
Concretion | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 6| 5| 4| 2| 4| 7| 7| 7| 7| 4| 7| 7| 4| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 6| 5| 5| 6| 5| 9| 5| 3| 3| 3| 3| 5| 3| 3| 5| 5| 5|
| 7| 7| 7| 7| 8| 7| 7| 7| 3| 7| 1| 1| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 3 2 2 1 1 1 2 |
Inflammation, Chronic Active | 4 |
Artery, Inflammation, Chronic | 3 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 1| 7| 7| 7| 4| 4| | |
DAY ON TEST | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5| | |
| 7| 8| 1| 9| 6| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + M + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M M + + | 41 |
Inflammation, Chronic, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 49 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + | 48 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + + + | 49 |
Artery, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + M + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + | 48 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + M + M + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Abscess | 3 | 1 3.0|
Abscess, Multiple | | 1 4.0|
Fatty Change | | 2 2.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Hepatodiaphragmatic Nodule | | 2 |
Mineralization, Focal | | 1 2.0|
Necrosis, Focal | | 3 2.0|
Hepatocyte, Hyperplasia, Focal | | 1 2.0|
Perivascular, Inflammation, Chronic | 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | 3 | 4 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + M + + + | 47 |
Inflammation, Chronic, Focal | 2 2 | 4 1.8|
Acinus, Atrophy | | 3 1.3|
Acinus, Hyperplasia | 3 | 1 3.0|
Periductular, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
Hyperplasia, Lymphoid | | 2 3.0|
Inflammation, Chronic, Focal | 2 2 2 1 | 38 1.9|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 49 |
Cyst | | 1 |
Hyperkeratosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 1| 7| 7| 7| 4| 4| | |
DAY ON TEST | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5| | |
| 7| 8| 1| 9| 6| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Abscess | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
Capsule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Cytoplasmic Alteration, Focal | | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + M + | 47 |
Hyperplasia | 2 4 | 8 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + | 47 |
Hyperplasia | 2 2 2 | 11 2.6|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + M M | 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 48 |
Pars Distalis, Cyst | 2 X | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + M + + + | 49 |
Inflammation, Chronic, Focal | | 5 1.0|
C-Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Penis | | 2 |
Inflammation, Acute | | 1 4.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 1| 7| 7| 7| 4| 4| | |
DAY ON TEST | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5| | |
| 7| 8| 1| 9| 6| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Abscess | | 4 3.8|
Ectasia | 3 | 4 3.3|
Inflammation, Chronic | | 11 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 48 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Acute | 3 | 2 3.5|
Inflammation, Chronic | 2 2 | 9 1.4|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 49 |
Atrophy | | 3 1.3|
Dilatation | | 4 2.8|
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Hypospermia, Focal | | 1 3.0|
Seminiferous Tubule, Atrophy | | 5 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Hypochromasia | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Hyperplasia, Neutrophil | | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + + | 49 |
Inguinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
Inguinal, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
Lumbar, Hyperplasia, Lymphoid | | 2 3.5|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 2 2.5|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + M + + + | 43 |
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Plasma Cell | 4 2 3 | 19 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + M + M + | 43 |
Congestion | 4 | 14 2.9|
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 1| 7| 7| 7| 4| 4| | |
DAY ON TEST | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5| | |
| 7| 8| 1| 9| 6| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atrophy | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 2 | 19 3.0|
Hyperplasia, Lymphoid | 4 | 6 2.8|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M M + M M M M M | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 48 |
Fibrosis | 3 | 1 3.0|
Ulcer | 4 | 6 2.8|
Dermis, Inflammation, Chronic | | 2 2.5|
Epidermis, Inflammation, Acute | | 1 3.0|
Subcutaneous Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
Hyperostosis | | 1 3.0|
Cranium, Fibrous Osteodystrophy | | 1 |
Tarsal, Hyperostosis | 4 3 4 4 4 3 3 | 44 3.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Mineralization, Focal | 2 | 19 1.9|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 4.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Perivascular, Inflammation, Chronic | 2 | 22 2.0|
Pleura, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 47 |
Inflammation, Chronic | | 1 3.0|
Metaplasia, Squamous | 3 3 | 17 2.3|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 | 21 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 1| 7| 7| 7| 4| 4| | |
DAY ON TEST | 3| 1| 4| 1| 7| 3| 3| 3| 5| 5| | |
| 7| 8| 1| 9| 6| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + M + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Congestion | | 2 1.5|
Glomerulosclerosis | 4 3 3 | 7 3.0|
Hydronephrosis | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 2 3.0|
Inflammation, Acute, Focal | | 1 4.0|
Inflammation, Chronic, Focal | 1 | 26 1.6|
Mineralization | | 1 1.0|
Capsule, Fibrosis | 2 | 1 2.0|
Pelvis, Inflammation, Acute | 3 | 1 3.0|
Renal Tubule, Regeneration | 1 1 4 1 | 25 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + | 47 |
Calculus Gross Observation | X | 1 |
Concretion | | 1 2.0|
Inflammation, Chronic, Focal | 2 | 23 1.6|
Inflammation, Chronic Active | 3 | 2 3.5|
Artery, Inflammation, Chronic | | 1 3.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 5| 4| 4| 4| 7| 7| 4| 1| 0| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 7| 5| 3| 3| 3| 3| 7| 3| 0| 5| 5| 5| 3| 3| 5| 1| 8| 3| 3| 3| 3| 5|
| 5| 5| 5| 1| 7| 5| 5| 5| 5| 1| 5| 2| 6| 7| 6| 5| 5| 6| 1| 7| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + + A M + + M + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + M M + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A M + A + + + + + |
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + A A + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | |
Cytoplasmic Alteration, Focal | |
Fatty Change | 1 |
Hematopoietic Cell Proliferation | |
Necrosis, Focal | 4 |
Hepatocyte, Hyperplasia, Focal | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | |
Hemorrhage | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + |
Inflammation, Chronic, Focal | 2 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + |
Inflammation, Chronic, Focal | 1 2 2 2 1 2 2 2 1 3 2 1 2 3 2 2 |
Karyomegaly | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Acanthosis | 4 |
Cyst Epithelial Inclusion | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + M + + + + + |
Inflammation, Acute | |
Inflammation, Chronic | |
Mineralization, Focal | |
Mineralization | 1 |
__________________________________________________________________________|
Tooth | |
Abscess | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 5| 4| 4| 4| 7| 7| 4| 1| 0| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 7| 5| 3| 3| 3| 3| 7| 3| 0| 5| 5| 5| 3| 3| 5| 1| 8| 3| 3| 3| 3| 5|
| 5| 5| 5| 1| 7| 5| 5| 5| 5| 1| 5| 2| 6| 7| 6| 5| 5| 6| 1| 7| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Cytoplasmic Alteration, Focal | 2 2 2 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + M + + |
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + + + M + + + + M M M + |
__________________________________________________________________________|
Pituitary Gland | I M + M + + + + + + + M + M + M + + + |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
Follicular Cell, Hyperplasia, Focal | 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Spermatocele | |
Duct, Dilatation | |
__________________________________________________________________________|
Penis | |
Abscess | |
Inflammation, Subacute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Abscess | 4 4 |
Ectasia | 4 |
Inflammation, Chronic | 2 4 3 4 3 2 2 2 |
__________________________________________________________________________|
Prostate | + M + + + + + + + + + + + + M + + + + |
Inflammation, Chronic | 2 2 2 2 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + M + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + |
Mineralization | |
Capsule, Inflammation, Chronic | 2 |
Seminiferous Tubule, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 5| 4| 4| 4| 7| 7| 4| 1| 0| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 7| 5| 3| 3| 3| 3| 7| 3| 0| 5| 5| 5| 3| 3| 5| 1| 8| 3| 3| 3| 3| 5|
| 5| 5| 5| 1| 7| 5| 5| 5| 5| 1| 5| 2| 6| 7| 6| 5| 5| 6| 1| 7| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | 2 3 4 |
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + M + + + M + + + + |
Inguinal, Congestion | |
Inguinal, Infiltration Cellular, | |
Plasma Cell | 4 |
Lumbar, Hyperplasia, Lymphoid | |
Lumbar, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Congestion | |
Renal, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M M M M M + M + M + M M M M M |
Infiltration Cellular, Plasma Cell | 2 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + M + + + M + + + + |
Congestion | 4 2 2 2 2 1 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 2 1 4 2 3 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | M M M M M + M + M M M + + + M + + M + |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M + M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
Tarsal, Hyperostosis | 4 4 4 4 4 4 4 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Hemorrhage, Focal | 1 |
Mineralization, Focal | 2 2 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Congestion | 2 4 |
Granuloma | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 5| 4| 4| 4| 7| 7| 4| 1| 0| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 7| 5| 3| 3| 3| 3| 7| 3| 0| 5| 5| 5| 3| 3| 5| 1| 8| 3| 3| 3| 3| 5|
| 5| 5| 5| 1| 7| 5| 5| 5| 5| 1| 5| 2| 6| 7| 6| 5| 5| 6| 1| 7| 5| 5| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 4 4 4 |
Bronchiole, Epithelium, Hyperplasia | 4 |
Bronchus, Foreign Body | 3 |
Perivascular, Inflammation, Chronic | 1 2 2 1 2 2 2 2 1 |
__________________________________________________________________________|
Nose | M + + + + + M + + M + + + + + + + + M |
Inflammation, Chronic | 3 2 |
Metaplasia, Squamous | 3 2 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Degeneration | |
Cornea, Inflammation, Acute | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + A + + + + + |
Abscess | 4 |
Congestion | 1 1 |
Fibrosis, Focal | 2 |
Glomerulosclerosis | 3 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 1 1 1 2 |
Inflammation, Subacute | |
Mineralization | 1 |
Papilla, Necrosis | 4 |
Renal Tubule, Casts | |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + A + + A + + + + + |
Calculus Gross Observation | |
Calculus Micro Observation Only | |
Concretion | 3 |
Inflammation, Chronic, Focal | 2 1 3 1 2 2 2 2 1 1 |
Inflammation, Subacute | |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5|
| 6| 6| 5| 5| 8| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.06% LM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + A + + + + A + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + M + + + + M + + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + M + + + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + M + + + + A + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + A + + + |
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + A + + + + + + + + + A + + + |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X |
Cytoplasmic Alteration, Focal | 2 4 4 |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Focal | 1 |
Hepatocyte, Hyperplasia, Focal | 3 |
Perivascular, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | 2 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 2 2 3 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 2 2 1 2 2 2 2 3 1 2 2 2 3 2 |
Karyomegaly | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + |
Acanthosis | |
Cyst Epithelial Inclusion | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + M + + + + + + + + + A + + + |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 2 |
Mineralization, Focal | 2 |
Mineralization | |
__________________________________________________________________________|
Tooth | |
Abscess | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 1 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5|
| 6| 6| 5| 5| 8| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.06% LM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + M + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + M + + + + + + + |
Cytoplasmic Alteration, Focal | 2 2 2 2 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + + + |
Hyperplasia | 1 2 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + M + M + + + + + + + M + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + M M + + + M + + + + + + + + + + + + + |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + |
Follicular Cell, Hyperplasia, Focal | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 1 |
Spermatocele | X |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Penis | + |
Abscess | 4 |
Inflammation, Subacute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + |
Abscess | 4 4 3 4 4 |
Ectasia | |
Inflammation, Chronic | 4 2 |
__________________________________________________________________________|
Prostate | M + + + M + + + M + + + + + + + + + + + + + M |
Inflammation, Chronic | 1 2 2 2 |
Inflammation, Subacute | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + |
Mineralization | 3 2 2 2 |
Capsule, Inflammation, Chronic | |
Seminiferous Tubule, Atrophy | 1 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5|
| 6| 6| 5| 5| 8| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.06% LM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Neutrophil | 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + |
Inguinal, Congestion | 3 |
Inguinal, Infiltration Cellular, | |
Plasma Cell | 3 |
Lumbar, Hyperplasia, Lymphoid | |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 4 |
Mediastinal, Hyperplasia, Lymphoid | 4 |
Renal, Congestion | |
Renal, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + M + M + + + M M + + + M M M + M M M M |
Infiltration Cellular, Plasma Cell | 1 2 2 2 2 4 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + M + + + + + + + + + + + + + + + + + + |
Congestion | 3 3 2 2 3 3 4 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 3 3 4 3 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Thymus | M M + + M M + + M M + + M M M M + M M M M + + |
Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M M M M M M M M M M M + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + M + + + + + + + + + + + |
Inflammation, Chronic, Focal | 3 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + |
Tarsal, Hyperostosis | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage, Focal | |
Mineralization, Focal | 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 4 |
Granuloma | 2 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5|
| 6| 6| 5| 5| 8| 6| 6| 6| 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 2| 6| 6| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.06% LM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 4 |
Bronchiole, Epithelium, Hyperplasia | |
Bronchus, Foreign Body | |
Perivascular, Inflammation, Chronic | 3 2 2 2 1 2 3 2 1 2 2 2 |
__________________________________________________________________________|
Nose | + + + M + + + + M + + + M + + + + + + M + + + |
Inflammation, Chronic | 3 2 3 2 3 |
Metaplasia, Squamous | 3 3 3 2 3 3 2 4 3 2 3 3 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + M + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cornea, Degeneration | 3 |
Cornea, Inflammation, Acute | 3 |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + |
Abscess | |
Congestion | 1 |
Fibrosis, Focal | 2 |
Glomerulosclerosis | |
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic, Focal | 2 2 2 2 3 2 2 2 2 |
Inflammation, Subacute | |
Mineralization | 2 |
Papilla, Necrosis | |
Renal Tubule, Casts | |
Renal Tubule, Hyperplasia, Focal | 3 |
Renal Tubule, Regeneration | 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + M + + + + + + + + + + + + + |
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
Concretion | |
Inflammation, Chronic, Focal | 2 1 2 2 2 2 2 1 1 1 1 2 |
Inflammation, Subacute | 3 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2| | |
| 6| 6| 7| 1| 6| 6| 6| 6| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 50 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A | 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 45 |
Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A | 43 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Basophilic Focus | | 1 |
Cytoplasmic Alteration, Focal | 4 | 4 3.5|
Fatty Change | | 2 1.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis, Focal | 1 | 3 2.0|
Hepatocyte, Hyperplasia, Focal | | 1 3.0|
Perivascular, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Hemorrhage | | 1 2.0|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 49 |
Inflammation, Chronic, Focal | 2 | 10 1.9|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 49 |
Inflammation, Chronic, Focal | 2 3 2 1 2 2 | 36 1.9|
Karyomegaly | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 49 |
Acanthosis | | 1 4.0|
Cyst Epithelial Inclusion | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 47 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 2 1.5|
Mineralization, Focal | | 1 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2| | |
| 6| 6| 7| 1| 6| 6| 6| 6| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Abscess | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Cardiomyopathy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + M + + + + + | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + M + + + + + | 48 |
Cytoplasmic Alteration, Focal | 2 | 10 2.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + + + + + | 48 |
Hyperplasia | 2 | 7 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 48 |
Hyperplasia | 1 | 4 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + | 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + I + + + M | 39 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 49 |
Follicular Cell, Hyperplasia, Focal | 2 | 6 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
Inflammation, Chronic | 2 | 3 1.7|
Spermatocele | | 1 |
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Penis | + | 2 |
Abscess | | 1 4.0|
Inflammation, Subacute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 22 |
Abscess | 4 | 8 3.9|
Ectasia | 4 3 | 3 3.7|
Inflammation, Chronic | 2 1 2 | 13 2.5|
__________________________________________________________________________|____________|
Prostate | + + M + M + + + | 42 |
Inflammation, Chronic | 3 | 10 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2| | |
| 6| 6| 7| 1| 6| 6| 6| 6| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Subacute | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 49 |
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Mineralization | | 4 2.3|
Capsule, Inflammation, Chronic | | 1 2.0|
Seminiferous Tubule, Atrophy | 2 | 6 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + M | 49 |
Hyperplasia, Neutrophil | 3 2 | 7 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 47 |
Inguinal, Congestion | | 1 3.0|
Inguinal, Infiltration Cellular, | | |
Plasma Cell | | 2 3.5|
Lumbar, Hyperplasia, Lymphoid | 2 | 1 2.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 4.0|
Renal, Congestion | 4 | 1 4.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M M M + M | 20 |
Infiltration Cellular, Plasma Cell | 2 2 | 15 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 45 |
Congestion | 3 1 4 2 4 | 18 2.6|
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Lymphoid | 4 | 1 4.0|
Infiltration Cellular, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 3 4 3 2 3 4 | 18 3.0|
Hyperplasia, Lymphoid | | 2 3.5|
__________________________________________________________________________|____________|
Thymus | M + M M M M M M | 18 |
Hyperplasia, Lymphoid | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 49 |
Inflammation, Chronic, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2| | |
| 6| 6| 7| 1| 6| 6| 6| 6| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Ulcer | 4 2 | 3 2.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + M | 49 |
Tarsal, Hyperostosis | 4 4 4 4 4 4 | 35 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Hemorrhage, Focal | | 1 1.0|
Mineralization, Focal | 2 2 2 2 1 | 23 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | | 3 3.3|
Granuloma | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 | 6 3.3|
Bronchiole, Epithelium, Hyperplasia | | 1 4.0|
Bronchus, Foreign Body | | 1 3.0|
Perivascular, Inflammation, Chronic | 2 2 2 | 24 1.9|
__________________________________________________________________________|____________|
Nose | + + + + M + + M | 40 |
Inflammation, Chronic | | 7 2.6|
Metaplasia, Squamous | 2 2 3 3 | 20 2.7|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 | 25 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Cornea, Degeneration | | 1 3.0|
Cornea, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 49 |
Abscess | | 1 4.0|
Congestion | | 3 1.0|
Fibrosis, Focal | | 2 2.0|
Glomerulosclerosis | | 1 3.0|
Inflammation, Acute, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 5| 5| 5| 3| 3| 3| 3| 2| | |
| 6| 6| 7| 1| 6| 6| 6| 6| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | 2 2 1 2 2 | 18 1.8|
Inflammation, Subacute | 4 | 1 4.0|
Mineralization | 4 | 3 2.3|
Papilla, Necrosis | 4 | 2 4.0|
Renal Tubule, Casts | 4 | 1 4.0|
Renal Tubule, Hyperplasia, Focal | | 1 3.0|
Renal Tubule, Regeneration | 1 1 1 | 15 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 46 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 1 |
Concretion | | 1 3.0|
Inflammation, Chronic, Focal | 2 2 3 | 25 1.7|
Inflammation, Subacute | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 1| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 9| 6|
| 1| 1| 1| 1| 6| 1| 1| 7| 8| 6| 4| 4| 2| 6| 6| 4| 4| 4| 9| 6| 4| 4| 4| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + M + + M + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Focal | 3 |
Thrombosis | |
Hepatocyte, Hyperplasia, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic, Focal | 2 |
Acinus, Atrophy | |
Acinus, Vacuolization Cytoplasmic | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 2 3 1 2 2 2 1 2 2 2 2 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 2 |
Inflammation, Chronic | 1 2 1 |
Mineralization | 2 |
__________________________________________________________________________|
Tooth | + |
Abscess | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 1| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 9| 6|
| 1| 1| 1| 1| 6| 1| 1| 7| 8| 6| 4| 4| 2| 6| 6| 4| 4| 4| 9| 6| 4| 4| 4| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cytoplasmic Alteration, Focal | 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M M + M + + + M + M M M M M M M + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + I + + M + + + M + I M + M +|
Pars Distalis, Congestion | |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic, Focal | 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia, Focal | 2 3 2 1 2 1 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Abscess | |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Abscess | 4 |
Ectasia | 3 3 4 |
Inflammation, Chronic | 3 3 1 |
__________________________________________________________________________|
Prostate | + M + + + + + + + + + M + + + + + M + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + M + + + + + + + +|
Atrophy | |
Dilatation | |
Hemorrhage | |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hypospermia, Focal | |
Capsule, Fibrosis | |
Seminiferous Tubule, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + M M +|
Inguinal, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 1| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 9| 6|
| 1| 1| 1| 1| 6| 1| 1| 7| 8| 6| 4| 4| 2| 6| 6| 4| 4| 4| 9| 6| 4| 4| 4| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Plasma Cell | 4 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 4|
Renal, Congestion | |
Renal, Infiltration Cellular, Plasma | |
Cell | 4|
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + M + M M M + M M M + M + M M M +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 2 1 2 2 2 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M M +|
Congestion | 2 2 4 1 2 3 2 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 2 4 4 2 2 2 |
Hyperplasia, Lymphoid | 4 4 3|
Infiltration Cellular, Plasma Cell | 2|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Thymus | + + + + M + M I + + + M + + M + M M M +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Scrotal, Subcutaneous Tissue, | |
Thrombosis | |
Subcutaneous Tissue, Mineralization, | |
Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Tarsal, Fibrosis | 4|
Tarsal, Hyperostosis | 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 X|
Tarsal, Inflammation, Acute | 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 5| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 5| 0| 5| 3| 3| 1| 5| 5| 3| 3| 3| 0| 5| 3| 3| 3| 9| 6|
| 1| 1| 1| 1| 6| 1| 1| 7| 8| 6| 4| 4| 2| 6| 6| 4| 4| 4| 9| 6| 4| 4| 4| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 4 |
Alveolar Epithelium, Metaplasia | |
Bronchiole, Epithelium, Hyperplasia | 3 |
Perivascular, Inflammation, Chronic | 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Metaplasia, Squamous | 2 2 2 2 2 2 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 3 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | |
Glomerulosclerosis | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Acute, Focal | 3 |
Inflammation, Chronic, Focal | 2 1 1 2 2 2 2 1|
Mineralization | 2 |
Necrosis, Focal | 2 |
Renal Tubule, Atrophy, Focal | |
Renal Tubule, Degeneration | |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Necrosis | |
Renal Tubule, Regeneration | 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 2 2 1 2 2 2 2 1|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 5| 3| 3| 5| 5| 3| 3| 3| 8| 5| 3| 5| 5| 5| 5| 3| 3| 8| 6| 4| 3| 3| 3| 6| 1|
| 4| 4| 4| 7| 6| 4| 4| 4| 7| 6| 4| 5| 0| 6| 6| 5| 5| 0| 1| 4| 5| 5| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% MM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + M + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Fatty Change | |
Hematopoietic Cell Proliferation | |
Necrosis, Focal | 3 4 4 |
Thrombosis | X |
Hepatocyte, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Inflammation, Chronic, Focal | 2 2 |
Acinus, Atrophy | |
Acinus, Vacuolization Cytoplasmic | 3 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 1 1 2 2 1 1 2 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 1 1 |
Mineralization | |
__________________________________________________________________________|
Tooth | |
Abscess | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 5| 3| 3| 5| 5| 3| 3| 3| 8| 5| 3| 5| 5| 5| 5| 3| 3| 8| 6| 4| 3| 3| 3| 6| 1|
| 4| 4| 4| 7| 6| 4| 4| 4| 7| 6| 4| 5| 0| 6| 6| 5| 5| 0| 1| 4| 5| 5| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% MM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cytoplasmic Alteration, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + + M + +|
Hyperplasia | 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 2 2 2 2 1 2|
__________________________________________________________________________|
Parathyroid Gland | + M + M M M + M + + + + + + M + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M M + M + + + + + + M + + + +|
Pars Distalis, Congestion | 3 |
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic, Focal | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia, Focal | 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
Abscess | 4 |
__________________________________________________________________________|
Preputial Gland | + + + |
Abscess | 4 4 |
Ectasia | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Dilatation | 2|
Hemorrhage | 4|
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hypospermia, Focal | |
Capsule, Fibrosis | 3 |
Seminiferous Tubule, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 5| 3| 3| 5| 5| 3| 3| 3| 8| 5| 3| 5| 5| 5| 5| 3| 3| 8| 6| 4| 3| 3| 3| 6| 1|
| 4| 4| 4| 7| 6| 4| 4| 4| 7| 6| 4| 5| 0| 6| 6| 5| 5| 0| 1| 4| 5| 5| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% MM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Plasma Cell | |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 4 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Renal, Congestion | 4 |
Renal, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + M + M + M + M M M M M M M M M + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 4 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + M + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hematopoietic Cell Proliferation | 4 2 4 4 4 2 3|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | |
Inflammation, Acute | |
__________________________________________________________________________|
Thymus | + + + M + + + M M M M M + M M + + + + + M|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Scrotal, Subcutaneous Tissue, | |
Thrombosis | X|
Subcutaneous Tissue, Mineralization, | |
Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Fibrosis | |
Tarsal, Hyperostosis | 4 4 4 4 4 4 4 4 4 4 4 X 4 4 4 4|
Tarsal, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 2 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 5| 3| 3| 5| 5| 3| 3| 3| 8| 5| 3| 5| 5| 5| 5| 3| 3| 8| 6| 4| 3| 3| 3| 6| 1|
| 4| 4| 4| 7| 6| 4| 4| 4| 7| 6| 4| 5| 0| 6| 6| 5| 5| 0| 1| 4| 5| 5| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% MM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Metaplasia | 2 |
Bronchiole, Epithelium, Hyperplasia | |
Perivascular, Inflammation, Chronic | 2 1 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + M + + M + +|
Inflammation, Chronic | 2 3 3 3 |
Metaplasia, Squamous | 2 2 4 3 3 3 2 3 3 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Cyst | X |
Glomerulosclerosis | 4 4|
Hyperplasia, Lymphoid | |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 1 2 2 2 2 2 2 2 2 1 1 |
Mineralization | 3|
Necrosis, Focal | |
Renal Tubule, Atrophy, Focal | |
Renal Tubule, Degeneration | 4 |
Renal Tubule, Dilatation | |
Renal Tubule, Necrosis | 2|
Renal Tubule, Regeneration | 1 1 1 2 1 2 1 3 1|
__________________________________________________________________________|
Urinary Bladder | + M + + + + + A + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | 2 2 2 3 2 2|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5| | |
| 5| 5| 5| 5| 5| 5| 5| 7| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A | 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + M + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Basophilic Focus | X | 2 |
Fatty Change | 2 | 2 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis, Focal | 1 1 | 6 2.7|
Thrombosis | | 1 |
Hepatocyte, Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Congestion | | 2 2.5|
Inflammation, Chronic, Focal | 2 1 | 5 1.8|
Acinus, Atrophy | 4 | 1 4.0|
Acinus, Vacuolization Cytoplasmic | | 1 3.0|
Duct, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Congestion | | 1 1.0|
Hyperplasia, Lymphoid | 1 | 1 1.0|
Inflammation, Chronic, Focal | 1 2 1 2 2 1 | 35 1.7|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Acanthosis | | 2 3.0|
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 49 |
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic | | 5 1.2|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Abscess | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5| | |
| 5| 5| 5| 5| 5| 5| 5| 7| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 49 |
Cytoplasmic Alteration, Focal | | 5 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 48 |
Hyperplasia | 1 | 5 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 48 |
Hyperplasia | 1 2 | 9 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M + + + + | 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + | 39 |
Pars Distalis, Congestion | 4 | 2 3.5|
Pars Distalis, Cyst | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Congestion | 1 | 1 1.0|
Inflammation, Chronic, Focal | 1 | 2 1.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia, Focal | 1 | 12 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Penis | | 1 |
Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + | 12 |
Abscess | 4 4 4 | 6 4.0|
Ectasia | | 3 3.3|
Inflammation, Chronic | | 4 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 47 |
Inflammation, Chronic | 2 | 5 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 49 |
Atrophy | | 1 3.0|
Dilatation | | 1 2.0|
Hemorrhage | | 1 4.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5| | |
| 5| 5| 5| 5| 5| 5| 5| 7| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hemorrhage | | 1 2.0|
Hypospermia, Focal | 1 | 1 1.0|
Capsule, Fibrosis | | 1 3.0|
Seminiferous Tubule, Atrophy | | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Hyperplasia, Neutrophil | 3 3 2 3 | 6 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + M + | 47 |
Inguinal, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | 4 | 2 4.0|
Mediastinal, Hyperplasia, Lymphoid | 1 | 1 1.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
Renal, Congestion | | 1 4.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + M M + M + | 17 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
Infiltration Cellular, Plasma Cell | | 11 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + | 47 |
Congestion | 2 2 | 13 2.6|
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 49 |
Congestion | | 2 2.0|
Hematopoietic Cell Proliferation | 3 4 | 16 3.1|
Hyperplasia, Lymphoid | 1 2 | 5 2.8|
Infiltration Cellular, Plasma Cell | | 1 2.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M M + + + + M M M | 28 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Inflammation, Chronic | | 1 1.0|
Scrotal, Subcutaneous Tissue, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5| | |
| 5| 5| 5| 5| 5| 5| 5| 7| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Thrombosis | | 1 |
Subcutaneous Tissue, Mineralization, | | |
Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
Tarsal, Fibrosis | | 1 4.0|
Tarsal, Hyperostosis | 4 4 4 4 4 4 4 4 | 41 4.0|
Tarsal, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Mineralization, Focal | 2 | 19 1.9|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Hemorrhage, Focal | 3 | 1 3.0|
Hyperplasia, Lymphoid | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | | 1 4.0|
Alveolar Epithelium, Metaplasia | | 1 2.0|
Bronchiole, Epithelium, Hyperplasia | | 1 3.0|
Perivascular, Inflammation, Chronic | | 9 1.9|
__________________________________________________________________________|____________|
Nose | + + + M + + + M + | 46 |
Inflammation, Chronic | 2 | 5 2.6|
Metaplasia, Squamous | 2 2 | 19 2.4|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 2 | 30 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Congestion | 1 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 4| 6| 5| | |
| 5| 5| 5| 5| 5| 5| 5| 7| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cyst | | 1 |
Glomerulosclerosis | | 3 3.3|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation, Acute, Focal | | 1 3.0|
Inflammation, Chronic, Focal | 2 2 2 | 22 1.7|
Mineralization | | 2 2.5|
Necrosis, Focal | | 1 2.0|
Renal Tubule, Atrophy, Focal | 2 | 1 2.0|
Renal Tubule, Degeneration | | 1 4.0|
Renal Tubule, Dilatation | | 1 3.0|
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Regeneration | 1 1 1 | 16 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A | 46 |
Ectasia | 3 | 1 3.0|
Hyperplasia, Lymphoid | 1 | 1 1.0|
Inflammation, Chronic, Focal | 2 1 2 2 | 18 1.9|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|
| 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M |
Acanthosis | |
Cyst | |
Hyperkeratosis | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + + A A A + M + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + A + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + A + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + M + + M + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M A + + A + + |
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + M + + + + + + + + + + + + A + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Abscess | |
Fatty Change | |
Infarct | |
Necrosis, Focal | |
Perivascular, Inflammation, Chronic | 1 1 1 2 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Edema | |
Inflammation, Chronic, Focal | 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + + |
Inflammation, Chronic, Focal | 2 2 1 2 2 2 2 2 1 1 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + |
Inflammation, Acute | |
Inflammation, Chronic | |
Mineralization | |
__________________________________________________________________________|
Tooth | + + |
Abscess | 3 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | |
Inflammation, Chronic, Focal | |
Karyomegaly | |
Atrium, Thrombosis | |
Coronary Artery, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|
| 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Coronary Artery, Inflammation, | |
Chronic | 3 |
Myocardium, Inflammation, Acute, | |
Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + M + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + M + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | 2 |
Cytoplasmic Alteration, Focal | |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + I + + M + + + + + + + + + + |
Congestion | |
Hyperplasia | 2 2 1 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + M M + + M + + M + M M + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Congestion | 1 |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 1 2 |
Follicle, Inflammation, Acute, Focal | |
Follicular Cell, Hyperplasia, Focal | 2 3 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
Ectopic Tissue | |
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
Necrosis | |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + |
Abscess | 4 4 |
Ectasia | |
Inflammation, Chronic | 4 1 2 4 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + M + + + |
Inflammation, Chronic | 3 2 1 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
Abscess | 3 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|
| 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Mineralization | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + |
Hyperplasia, Neutrophil | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + M + + + + + |
Axillary, Hyperplasia, Lymphoid | 2 |
Axillary, Infiltration Cellular, | |
Plasma Cell | 4 4 |
Inguinal, Infiltration Cellular, | |
Plasma Cell | 4 |
Lumbar, Inflammation, Acute | 4 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 |
Pancreatic, Congestion | 3 |
Renal, Infiltration Cellular, Plasma | |
Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + M + + + + + |
Infiltration Cellular, Plasma Cell | 2 3 3 2 2 3 1 3 4 2 4 2 2 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + M + + + + + |
Congestion | 2 4 2 4 2 2 3 4 2 |
Hyperplasia, Lymphoid | 2 |
Lymphatic, Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + M + + + + + |
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 3 4 2 4 2 2 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + M + + M M M M + M M + M + M M M M + |
Infiltration Cellular, Plasma Cell | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Alopecia | 3 |
Fibrosis | |
Ulcer | 2 |
Dermis, Inflammation, Chronic | 4 |
Perivascular, Inflammation | |
Scrotal, Subcutaneous Tissue, | |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|
| 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Lymphatic, Dilatation | 4 |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Hyperplasia, | |
Lymphoid | |
Subcutaneous Tissue, Infiltration | |
Cellular, Plasma Cell | |
Subcutaneous Tissue, Inflammation, | |
Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Tarsal, Hyperostosis | 4 4 4 4 4 4 4 3 3 3 3 3 4 4 4 |
Tarsal, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Mineralization, Focal | 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Metaplasia | |
Perivascular, Inflammation, Chronic | 2 2 2 1 1 1 2 2 1 2 2 |
Pleura, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + M + + + + + + + + + + + |
Inflammation, Chronic | |
Metaplasia, Squamous | 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Cyst | X 2 |
Glomerulosclerosis | 3 3 |
Inflammation, Acute, Focal | 4 |
Inflammation, Chronic, Focal | 3 3 2 4 2 2 3 2 2 1 2 2 1 4 2 1 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 4| 4| 4| 4| 7| 7| 6| 3| 1| 7| 3| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 1| 5| 3| 3| 3| 5| 3| 2| 5| 5| 5| 1| 3| 3| 7| 9| 6| 3| 0| 3| 3| 5|
| 0| 9| 9| 5| 6| 1| 0| 0| 4| 0| 9| 7| 7| 6| 4| 1| 1| 6| 8| 9| 1| 1| 1| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Necrosis, Focal | 3 |
Nephropathy, Focal | |
Papilla, Necrosis | |
Renal Tubule, Casts | 3 |
Renal Tubule, Degeneration | |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Regeneration | 2 1 1 1 2 2 1 2 2 |
__________________________________________________________________________|
Urethra | + + |
Hemorrhage | 3 |
Inflammation, Acute | 3 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + A + + |
Concretion | 2 |
Ectasia | 4 |
Inflammation, Chronic, Focal | 2 2 1 4 2 2 1 1 4 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|
| 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Cyst | X |
Hyperkeratosis | 4 |
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + + + + + A + + + M|
__________________________________________________________________________|
Intestine Large | + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + A + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Fatty Change | |
Infarct | 4 |
Necrosis, Focal | 2 4 |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | M |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + M + + + +|
Edema | 3 |
Inflammation, Chronic, Focal | 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 1 2 2 2 2 1 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + +|
Inflammation, Acute | 2|
Inflammation, Chronic | 2 1 |
Mineralization | 3 |
__________________________________________________________________________|
Tooth | |
Abscess | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Inflammation, Chronic, Focal | |
Karyomegaly | 3 |
Atrium, Thrombosis | X |
Coronary Artery, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|
| 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Coronary Artery, Inflammation, | |
Chronic | |
Myocardium, Inflammation, Acute, | |
Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cytoplasmic Alteration, Focal | 2 3 2 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia | 1 |
Inflammation, Acute | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + M + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M M + + M + + M M M + M M +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + M + + + + M + + + + + + M +|
Pars Distalis, Congestion | |
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Follicle, Inflammation, Acute, Focal | |
Follicular Cell, Hyperplasia, Focal | 3 2 3 3 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
Necrosis | |
__________________________________________________________________________|
Preputial Gland | + + +|
Abscess | 4|
Ectasia | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Abscess | |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|
| 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Mineralization | 3 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + A + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Axillary, Infiltration Cellular, | |
Plasma Cell | |
Inguinal, Infiltration Cellular, | |
Plasma Cell | |
Lumbar, Inflammation, Acute | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Pancreatic, Congestion | |
Renal, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M A + + M + + + + + M + M + + + +|
Infiltration Cellular, Plasma Cell | 2 2 4 2 2 3 2 4 4 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + A + + + + + M + + + + + + + + M|
Congestion | 3 2 4 2 |
Hyperplasia, Lymphoid | |
Lymphatic, Angiectasis | 2 |
__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 4 4 3 3 3|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M M + + M M M + M + + M M + + + M M + M|
Infiltration Cellular, Plasma Cell | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M + M M M M M M + M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Fibrosis | |
Ulcer | 4 4 |
Dermis, Inflammation, Chronic | |
Perivascular, Inflammation | |
Scrotal, Subcutaneous Tissue, | |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|
| 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Lymphatic, Dilatation | |
Subcutaneous Tissue, Abscess | 3 |
Subcutaneous Tissue, Hyperplasia, | |
Lymphoid | 3 |
Subcutaneous Tissue, Infiltration | |
Cellular, Plasma Cell | 4 |
Subcutaneous Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | 4 4 4 4 3 3 4 3 4 4 4 4 X X 4 3 4 4|
Tarsal, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 2 2 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | 4 |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Metaplasia | 2 |
Perivascular, Inflammation, Chronic | 2 2 2 2 2 2 2 3|
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + M + + + + + +|
Inflammation, Chronic | 3 |
Metaplasia, Squamous | 2 3 2 3 3 2 2 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 1 |
Cyst | |
Glomerulosclerosis | 3 3 3|
Inflammation, Acute, Focal | 4 |
Inflammation, Chronic, Focal | 2 2 1 2 2 2 2 3|
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 6| 6| 5| 4| 0| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 5| 5| 3| 3| 1| 5| 3| 3| 1| 5| 5| 3| 3| 3| 7| 5| 8| 3| 3| 3| 1|
| 1| 1| 1| 1| 6| 0| 1| 1| 2| 6| 1| 1| 5| 7| 7| 1| 7| 2| 0| 7| 4| 1| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Necrosis, Focal | |
Nephropathy, Focal | 1 |
Papilla, Necrosis | |
Renal Tubule, Casts | |
Renal Tubule, Degeneration | |
Renal Tubule, Hyperplasia, Focal | 2 1 |
Renal Tubule, Regeneration | 2 1 2 1 1 1 1 2 2 3|
__________________________________________________________________________|
Urethra | |
Hemorrhage | |
Inflammation, Acute | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + A + + + +|
Concretion | 3 |
Ectasia | |
Inflammation, Chronic, Focal | 2 2 2 1 3 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 5| 0| | |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0| | |
| 1| 1| 1| 1| 5| 1| 1| 3| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 49 |
Acanthosis | | 1 4.0|
Cyst | | 1 |
Hyperkeratosis | | 1 4.0|
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + A | 40 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A | 44 |
Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A | 45 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Abscess | | 1 3.0|
Fatty Change | 2 | 1 2.0|
Infarct | | 1 4.0|
Necrosis, Focal | 1 | 3 2.3|
Perivascular, Inflammation, Chronic | | 5 1.4|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 48 |
Edema | | 1 3.0|
Inflammation, Chronic, Focal | 1 2 1 2 | 9 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 49 |
Inflammation, Chronic, Focal | 1 1 1 2 2 1 2 | 31 1.7|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 48 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 1 1 | 4 1.3|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Abscess | | 1 3.0|
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 5| 0| | |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0| | |
| 1| 1| 1| 1| 5| 1| 1| 3| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 | 2 2.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
Karyomegaly | | 1 3.0|
Atrium, Thrombosis | | 1 |
Coronary Artery, Inflammation, Acute | | 1 2.0|
Coronary Artery, Inflammation, | | |
Chronic | 1 | 2 2.0|
Myocardium, Inflammation, Acute, | | |
Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 49 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Cytoplasmic Alteration, Focal | 2 1 | 6 2.0|
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 48 |
Congestion | | 1 2.0|
Hyperplasia | 2 | 5 1.6|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 48 |
Hyperplasia | 1 1 2 | 7 1.4|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M M + + + + | 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 46 |
Pars Distalis, Congestion | | 1 1.0|
Pars Distalis, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Inflammation, Chronic, Focal | | 3 1.7|
Follicle, Inflammation, Acute, Focal | 2 | 1 2.0|
Follicular Cell, Hyperplasia, Focal | 1 4 2 2 | 15 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
Ectopic Tissue | X | 1 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 5| 0| | |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0| | |
| 1| 1| 1| 1| 5| 1| 1| 3| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 11 |
Abscess | | 3 4.0|
Ectasia | 3 | 1 3.0|
Inflammation, Chronic | | 6 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 48 |
Inflammation, Chronic | 1 | 7 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 50 |
Abscess | | 1 3.0|
Atrophy | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Congestion | | 1 2.0|
Mineralization | 4 | 2 3.5|
Seminiferous Tubule, Atrophy | 3 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 49 |
Hyperplasia, Neutrophil | 2 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + M | 47 |
Axillary, Hyperplasia, Lymphoid | | 1 2.0|
Axillary, Infiltration Cellular, | | |
Plasma Cell | | 2 4.0|
Inguinal, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
Lumbar, Inflammation, Acute | | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Pancreatic, Congestion | | 1 3.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + M + M | 40 |
Infiltration Cellular, Plasma Cell | 2 2 2 3 2 | 31 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M M | 42 |
Congestion | 4 2 4 2 | 17 2.8|
Hyperplasia, Lymphoid | | 1 2.0|
Lymphatic, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 5| 0| | |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0| | |
| 1| 1| 1| 1| 5| 1| 1| 3| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | | 1 3.0|
Hematopoietic Cell Proliferation | 2 3 3 4 3 | 17 3.1|
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | M + M + M + + + M + | 22 |
Infiltration Cellular, Plasma Cell | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M M | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Alopecia | | 1 3.0|
Fibrosis | 3 | 1 3.0|
Ulcer | | 3 3.3|
Dermis, Inflammation, Chronic | | 1 4.0|
Perivascular, Inflammation | 2 | 1 2.0|
Scrotal, Subcutaneous Tissue, | | |
Lymphatic, Dilatation | | 1 4.0|
Subcutaneous Tissue, Abscess | | 1 3.0|
Subcutaneous Tissue, Hyperplasia, | | |
Lymphoid | | 1 3.0|
Subcutaneous Tissue, Infiltration | | |
Cellular, Plasma Cell | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Tarsal, Hyperostosis | 4 4 4 4 4 4 | 39 3.8|
Tarsal, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Mineralization, Focal | 2 2 2 2 2 | 18 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | 3 | 2 2.5|
Infiltration Cellular, Histiocyte | | 1 4.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Alveolar Epithelium, Metaplasia | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05035-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/29/97
Route: DOSED FEED Time: 16:11:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 5| 5| 0| | |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 6| 2| 0| | |
| 1| 1| 1| 1| 5| 1| 1| 3| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Perivascular, Inflammation, Chronic | 1 2 | 21 1.8|
Pleura, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + M M M + M + + + + | 44 |
Inflammation, Chronic | 2 | 2 2.5|
Metaplasia, Squamous | 2 2 2 | 13 2.2|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 | 19 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Congestion | 2 | 4 1.5|
Cyst | | 2 2.0|
Glomerulosclerosis | 3 | 6 3.0|
Inflammation, Acute, Focal | | 2 4.0|
Inflammation, Chronic, Focal | 2 3 3 2 | 28 2.2|
Mineralization | 3 | 2 2.5|
Necrosis, Focal | 2 1 2 | 4 2.0|
Nephropathy, Focal | | 1 1.0|
Papilla, Necrosis | 4 | 1 4.0|
Renal Tubule, Casts | | 1 3.0|
Renal Tubule, Degeneration | 1 | 1 1.0|
Renal Tubule, Hyperplasia, Focal | | 2 1.5|
Renal Tubule, Regeneration | 1 2 2 2 1 2 | 25 1.6|
__________________________________________________________________________|____________|
Urethra | | 2 |
Hemorrhage | | 1 3.0|
Inflammation, Acute | | 2 3.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A | 45 |
Concretion | | 2 2.5|
Ectasia | | 1 4.0|
Inflammation, Chronic, Focal | 2 2 2 1 2 | 19 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
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