TDMS Study 05035-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/04/94
EXP: 05035 4-HYDROXYACETANILIDE TIME: 22:38:36
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55801
CONT: N01CP9561902 CAS: 103-90-2
PATHOLOGIST: A. RUSSFIELD S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/04/94
EXP: 05035 4-HYDROXYACETANILIDE TIME: 22:38:36
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55801
CONT: N01CP9561902 CAS: 103-90-2
PATHOLOGIST: A. RUSSFIELD S. EUSTIS
4-HYDROXYACETANILIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL UM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 176 267 293 419 463 479 541 561 563 578 |
| 618 651 654 654 671 689 703 718 |
| CENSORED DEATHS |
| 456 456 456 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.06% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 78 87 111 122 424 442 502 651 671 671 |
| CENSORED DEATHS |
| 456 456 456 456 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 461 510 512 563 608 644 647 650 654 655 |
| 657 657 661 666 680 687 695 709 715 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
4-HYDROXYACETANILIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.6% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 7 84 169 301 398 414 512 523 563 570 |
| 605 632 637 650 654 676 715 715 717 |
| CENSORED DEATHS |
| 456 456 456 456 456 457 457 457 457 457 |
| |
==================================================================================
4-HYDROXYACETANILIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL UM | 100.0 98.3 96.7 95.0 93.3 89.3 87.2 81.2 73.0 64.9 |
| | |
| | |
|0.06% | 96.7 93.3 93.3 93.3 91.7 90.0 88.0 88.0 85.9 81.8 |
| | |
| | |
|0.3% | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 92.0 74.0 62.0 |
| | |
| | |
|0.6% | 96.7 95.0 95.0 93.3 90.0 90.0 85.9 79.8 71.6 63.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL UM 0.06% 0.3% 0.6% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.9% 81.8% 62.0% 63.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.292 P=0.152N P=1.000N P=0.942 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 538.8 375.9 633.2 502.2 |
|NATURAL DEATHS (C) | (37.8) (80.2) (16.3) (50.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 626.6 624.8 653.2 611.8 |
|(STANDARD ERROR) | (18.4) (23.3) (13.7) (22.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4-HYDROXYACETANILIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL UF |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 23 CENSORED DEATHS 10 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 397 491 506 534 534 536 555 564 611 634 |
| 635 642 642 647 653 660 684 701 702 715 |
| 719 722 726 |
| CENSORED DEATHS |
| 457 457 457 457 457 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.06% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 436 449 516 547 549 551 599 614 633 634 |
| 638 638 661 661 667 678 680 691 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 14 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 414 480 488 516 534 540 549 551 551 607 |
| 610 639 642 659 659 684 684 701 705 716 |
| 726 |
| CENSORED DEATHS |
| 8 8 8 9 457 457 457 457 457 457 |
| 458 458 458 458 |
| |
==================================================================================
4-HYDROXYACETANILIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.6% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 12 CENSORED DEATHS 10 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 251 522 536 579 593 596 620 631 632 635 |
| 642 661 |
| CENSORED DEATHS |
| 457 457 457 458 458 458 458 458 458 458 |
| |
==================================================================================
4-HYDROXYACETANILIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL UF | 100.0 100.0 100.0 100.0 98.3 98.3 88.3 84.3 68.2 54.2 |
| | |
| | |
|0.06% | 100.0 100.0 100.0 100.0 100.0 96.7 94.7 86.6 72.5 64.4 |
| | |
| | |
|0.3% | 100.0 100.0 100.0 100.0 98.2 96.0 87.3 80.8 67.7 54.6 |
| | |
| | |
|0.6% | 100.0 100.0 98.3 98.3 98.3 98.3 94.3 88.3 76.3 76.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL UF 0.06% 0.3% 0.6% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 54.2% 64.4% 54.6% 76.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.105N P=0.477N P=1.000 P=0.053N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 617.8 602.3 602.6 574.8 |
|NATURAL DEATHS (C) | (18.4) (18.3) (19.4) (31.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 641.6 646.3 591.9 653.6 |
|(STANDARD ERROR) | (14.4) (14.2) (24.8) (15.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4-HYDROXYACETANILIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL UM = 1
0.06% = 2
0.3% = 3
0.6% = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 14 2 1 3
| 4 22 1 1
| 3 3
| 42 2 4 1 1 33
95 + 2 2 4 14 1
| 2 4 4 12 1 3 3
| 3 3
| 4 42 2 1 1
P 90 + 4 2 2 4 3 3
E | 1 1
R | 2 4 4 1 1 32
C | 4 4 2 2
E 85 +
N | 141 33
T |
| 41 4 1 2 2
S 80 + 4 4
U | 1 1
R | 11
V | 4 43 3
I 75 +
V | 44 33
A | 1 1 3
L | 4 14 1
70 + 433 4
| 1 1
| 331 1
| 3 3
65 + 1 1
| 33 4
| 3 3
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
4-HYDROXYACETANILIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL UF = 1
0.06% = 2
0.3% = 3
0.6% = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 1 3 2
| 4 1 3 2 2 3 1 4
|
| 2 331 12 4 4
95 + 2 2
| 3 13 1 4
| 4 4
| 3 3
90 + 33 44
| 1 21 2 4
| 33
| 11 2 24 4
P 85 + 2 2
E | 1 1
R | 1 1
C | 3 3
E 80 + 22
N | 33 11 4
T |
| 3 2 2 4
S 75 +
U | 11
R | 311 22
V |
I 70 + 1 122
V | 1 21
A | 3 3
L | 12 1
65 + 2 2
| 3 3
| 1 1
|
60 +
| 3 11
|
| 33
55 + 3 3
| 1 1
|
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
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