TDMS Study 05035-03 Pathology Tables
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
Facility: TSI Mason Research
Chemical CAS #: 103-90-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|
| 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + A + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + A + A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Mild | |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Mesentery | + |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + M + + + + + + + + + + |
Leukemia Mononuclear, Moderate | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M I + + + + + + + + + |
Leukemia Mononuclear, Marked | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M + M + + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|
| 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + |
Adenoma | |
Carcinoma | X |
Squamous Cell Papilloma | X |
Bilateral, Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + M + + + + + |
Granulosa Cell Tumor Benign | |
Luteoma | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + M + + + + + |
Leiomyosarcoma | |
Polyp Stromal | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Mild | |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear, | |
Marked | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Mild | |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + |
Leukemia Mononuclear, Marked | X |
Lymphoma Malignant Lymphocytic | |
Thymoma Benign | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + M + + + + + + + + |
Fibroadenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 4| 7| 6| 4| 7| 4| 4| 5| 6| 6| 5| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 6| 3| 5| 3| 3| 6| 3| 7| 6| 3| 6| 6| 1| 6| 6| 9| 0| 6|
| 6| 6| 6| 6| 7| 3| 7| 3| 0| 2| 7| 7| 3| 7| 9| 4| 7| 4| 4| 7| 8| 4| 6| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Basal Cell Carcinoma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Schwannoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + |
Carcinoma, Metastatic, Pituitary | |
Gland | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Carcinoma Adenosquamous | X |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + A + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + M A + A + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|
| 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + A + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Mesentery | + + + |
Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear, Moderate | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + M + I + + + I + + + A + + I + M I M +|
Leukemia Mononuclear, Marked | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M M + + + + + + + + + M + I + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + A + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X|
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|
| 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Sarcoma | X |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + M M + M + M + + + + + + + + +|
Adenoma | X X |
Carcinoma | X X |
Squamous Cell Papilloma | |
Bilateral, Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
Luteoma | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
Polyp Stromal | X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Mild | |
Leukemia Mononuclear, Moderate | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear, | |
Marked | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + M + + + + A + M M + M + + +|
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Thymus | + M + + M M M + + + M + + + + + M M + + + M M|
Leukemia Mononuclear, Marked | |
Lymphoma Malignant Lymphocytic | X |
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + +|
Fibroadenoma | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 3| 3| 7| 6| 6| 5| 5| 7| 7| 4| 4| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 2| 2| 8| 2| 9| 8| 3| 4| 0| 7| 7| 3| 3| 6| 6| 0| 3| 3| 3| 9| 6|
| 7| 7| 7| 7| 9| 4| 3| 5| 6| 0| 7| 4| 7| 8| 5| 7| 7| 3| 3| 4| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma Adenosquamous | |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + |
__________________________________________________________________________|
Harderian Gland | + + + + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Leukemia Mononuclear, Marked | | 2 |
Leukemia Mononuclear, Mild | X | 2 |
Leukemia Mononuclear, Moderate | | 5 |
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + M | 47 |
Leukemia Mononuclear, Moderate | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 39 |
Leukemia Mononuclear, Marked | | 1 |
Pheochromocytoma Benign | X X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + M | 46 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + + + | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + | 47 |
Pars Distalis, Adenoma | X X X X | 23 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 49 |
C-Cell, Adenoma | X | 9 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Sarcoma | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + | 43 |
Adenoma | X | 3 |
Carcinoma | X | 4 |
Squamous Cell Papilloma | | 1 |
Bilateral, Adenoma | | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 49 |
Granulosa Cell Tumor Benign | X | 1 |
Luteoma | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 49 |
Leiomyosarcoma | | 1 |
Polyp Stromal | X X X X | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 31 |
Leukemia Mononuclear, Marked | | 1 |
Leukemia Mononuclear, Mild | X | 1 |
Leukemia Mononuclear, Moderate | | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Mediastinal, Leukemia Mononuclear, | | |
Marked | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 43 |
Leukemia Mononuclear, Marked | | 1 |
Leukemia Mononuclear, Moderate | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M | 48 |
Leukemia Mononuclear, Marked | | 1 |
Leukemia Mononuclear, Moderate | | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Leukemia Mononuclear, Marked | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear, Mild | X | 2 |
Leukemia Mononuclear, Moderate | | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + | 39 |
Leukemia Mononuclear, Marked | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Thymoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + | 46 |
Fibroadenoma | X X X | 19 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Basal Cell Carcinoma | | 1 |
Subcutaneous Tissue, Fibroma | X | 2 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 49 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Carcinoma Adenosquamous | | 1 |
Leukemia Mononuclear, Marked | | 2 |
Leukemia Mononuclear, Moderate | | 3 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
__________________________________________________________________________|____________|
Eye | | 9 |
__________________________________________________________________________|____________|
Harderian Gland | | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 7| 6| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A | 44 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|
| 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X X|
Leukemia Mononuclear, Mild | |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Leukemia Mononuclear, Marked | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear, Marked | X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + I + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | |
Pars Distalis, Adenoma | X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|
| 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X X|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X |
Leiomyosarcoma | X |
Leukemia Mononuclear, Marked | X |
Polyp Stromal | X X X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + I + + + + + + + + + + +|
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Lumbar, Leukemia Mononuclear, Marked | |
Mediastinal, Leukemia Mononuclear, | |
Marked | X X|
Mediastinal, Leukemia Mononuclear, | |
Moderate | |
Renal, Leukemia Mononuclear, Moderate| |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X X|
Leukemia Mononuclear, Moderate | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X X|
Leukemia Mononuclear, Mild | |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + M M M + A|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 6| 3| 6| 3| 3| 5| 6| 6| 3| 3| 3| 3| 9| 6| 6| 3| 3| 1| 3| 3| 3| 3| 7|
| 5| 5| 2| 5| 4| 6| 5| 5| 4| 3| 6| 6| 6| 5| 4| 3| 3| 6| 6| 0| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenocarcinoma | |
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + + + + M + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear, Marked | X X|
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + A|
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + A|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|
DAY ON TEST | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|
| 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
0.06% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Mild | X X |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + M + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
Leukemia Mononuclear, Marked | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + I + |
Leukemia Mononuclear, Marked | |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + I + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear, Marked | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|
DAY ON TEST | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|
| 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
0.06% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + M + + |
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Leiomyoma | |
Leiomyosarcoma | |
Leukemia Mononuclear, Marked | |
Polyp Stromal | X X X X X X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + + + + + + |
Lumbar, Leukemia Mononuclear, Marked | |
Mediastinal, Leukemia Mononuclear, | |
Marked | |
Mediastinal, Leukemia Mononuclear, | |
Moderate | |
Renal, Leukemia Mononuclear, Moderate| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + M + M |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Mild | X X |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + M + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + M + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 6| 5| 6| 7| 5| 4| 4|
DAY ON TEST | 3| 6| 3| 3| 8| 3| 3| 3| 3| 9| 3| 6| 3| 3| 1| 3| 3| 6| 8| 8| 2| 3| 0| 6| 6|
| 6| 4| 6| 6| 9| 6| 6| 6| 6| 9| 6| 3| 6| 6| 6| 6| 6| 3| 9| 1| 7| 6| 1| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
0.06% LF | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenocarcinoma | X |
Fibroadenoma | X X X X X X X X X X X X |
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + M + + M + + + + M + |
Basal Cell Adenoma | X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1| | |
| 6| 6| 6| 6| 6| 5| 6| 4| 6| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Leukemia Mononuclear, Marked | X | 3 |
Leukemia Mononuclear, Mild | | 2 |
Leukemia Mononuclear, Moderate | X X | 12 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Leukemia Mononuclear, Marked | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 47 |
Leukemia Mononuclear, Marked | X | 2 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 49 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Leukemia Mononuclear, Marked | X | 1 |
Pars Distalis, Adenoma | X X X X X X | 31 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1| | |
| 6| 6| 6| 6| 6| 5| 6| 4| 6| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Bilateral, C-Cell, Adenoma | X | 1 |
C-Cell, Adenoma | X X | 4 |
C-Cell, Carcinoma | X | 3 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + | 47 |
Adenoma | | 1 |
Carcinoma | X | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Leiomyoma | | 1 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear, Marked | | 1 |
Polyp Stromal | X X | 12 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 6 |
Leukemia Mononuclear, Marked | X | 1 |
Leukemia Mononuclear, Moderate | X | 5 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 49 |
Leukemia Mononuclear, Marked | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Lumbar, Leukemia Mononuclear, Marked | X | 1 |
Mediastinal, Leukemia Mononuclear, | | |
Marked | X | 3 |
Mediastinal, Leukemia Mononuclear, | | |
Moderate | X | 1 |
Renal, Leukemia Mononuclear, Moderate| X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 46 |
Leukemia Mononuclear, Marked | X | 3 |
Leukemia Mononuclear, Moderate | X X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1| | |
| 6| 6| 6| 6| 6| 5| 6| 4| 6| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear, Marked | X | 2 |
Leukemia Mononuclear, Moderate | X X | 12 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Leukemia Mononuclear, Marked | X | 3 |
Leukemia Mononuclear, Mild | | 2 |
Leukemia Mononuclear, Moderate | X X | 12 |
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + | 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 47 |
Adenocarcinoma | | 1 |
Fibroadenoma | X X X X X | 23 |
Fibroadenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 46 |
Basal Cell Adenoma | | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear, Marked | X | 3 |
Leukemia Mononuclear, Moderate | X X | 12 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 11 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 8 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 2| 1| | |
| 6| 6| 6| 6| 6| 5| 6| 4| 6| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.06% LF | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
Urinary Bladder | + + + + + M + + A + | 45 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + M M + M + + + M + M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M M M + + + + + M + + + + + M M +|
Adenoma | X X |
Carcinoma | X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | |
Polyp Stromal | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + I + + + + + + +|
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X|
Mediastinal, Leukemia Mononuclear, | |
Marked | X |
Pancreatic, Leukemia Mononuclear, | |
Marked | |
Pancreatic, Leukemia Mononuclear, | |
Moderate | |
Renal, Leukemia Mononuclear | X|
Renal, Leukemia Mononuclear, Marked | |
Renal, Leukemia Mononuclear, Moderate| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + M + M + +|
Leukemia Mononuclear | X|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Thymus | + + M + M + + + + + M M M + + + M M +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + M +|
Adenocarcinoma | X |
Fibroadenoma | X X X X X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 4| 7| 5| 4| 7| 7| 7| 4| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 6| 6| 3| 3| 6| 3| 1| 3| 6| 3| 0| 6| 3| 3| 3| 6| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 2| 2| 3| 2| 5| 5| 3| 5| 6| 4| 5| 5| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Sarcoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|
| 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.3% MF | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X|
Leukemia Mononuclear, Mild | X X |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Mesentery | + + + |
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + M + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + M + + M M + + + + + + I + M + +|
Leukemia Mononuclear, Marked | X|
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + I + + + + + + + + + + + + M + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|
| 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.3% MF | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + I M + + + + + + + M + M + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
Polyp Stromal | X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear, | |
Marked | X |
Pancreatic, Leukemia Mononuclear, | |
Marked | X X|
Pancreatic, Leukemia Mononuclear, | |
Moderate | X |
Renal, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear, Marked | |
Renal, Leukemia Mononuclear, Moderate| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X|
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|
| 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.3% MF | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X|
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X|
Leukemia Mononuclear, Mild | X X |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Thymus | + M + M + + + + + M + M + M + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X X X X X X X X|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + I|
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X|
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 7| 1| 5| 3| 3| 3| 1| 9| 3| 3| 3| 7| 6| 3| 3| 3| 4| 6| 3| 3| 3| 1| 9|
| 5| 5| 6| 1| 6| 5| 5| 5| 3| 1| 5| 5| 5| 0| 4| 5| 2| 2| 4| 3| 5| 5| 5| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.3% MF | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Sarcoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 4| 7| 4| 5| 4| | |
DAY ON TEST | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8| | |
| 5| 5| 5| 9| 2| 4| 5| 3| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 49 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Leukemia Mononuclear, Marked | X X | 5 |
Leukemia Mononuclear, Mild | | 3 |
Leukemia Mononuclear, Moderate | | 5 |
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 4| 7| 4| 5| 4| | |
DAY ON TEST | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8| | |
| 5| 5| 5| 9| 2| 4| 5| 3| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 44 |
Leukemia Mononuclear, Marked | | 2 |
Pheochromocytoma Benign | X | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 48 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + | 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X X | 27 |
Pars Distalis, Carcinoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
C-Cell, Adenoma | X X X | 6 |
C-Cell, Carcinoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + | 43 |
Adenoma | | 6 |
Carcinoma | | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | | 1 |
Polyp Stromal | X X | 14 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 4 |
Leukemia Mononuclear, Marked | | 1 |
Leukemia Mononuclear, Moderate | | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 49 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Mediastinal, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear, | | |
Marked | | 2 |
Pancreatic, Leukemia Mononuclear, | | |
Marked | X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 4| 7| 4| 5| 4| | |
DAY ON TEST | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8| | |
| 5| 5| 5| 9| 2| 4| 5| 3| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Leukemia Mononuclear, | | |
Moderate | | 1 |
Renal, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear, Marked | X | 1 |
Renal, Leukemia Mononuclear, Moderate| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + I + + + + + + | 45 |
Leukemia Mononuclear | | 2 |
Leukemia Mononuclear, Marked | X X | 5 |
Leukemia Mononuclear, Moderate | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
Leukemia Mononuclear, Marked | X X | 4 |
Leukemia Mononuclear, Moderate | | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Leukemia Mononuclear, Marked | X X | 5 |
Leukemia Mononuclear, Mild | | 3 |
Leukemia Mononuclear, Moderate | | 5 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + M | 36 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 48 |
Adenocarcinoma | | 1 |
Fibroadenoma | X X X X | 20 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + M + + + + + + | 48 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 4| 7| 4| 5| 4| | |
DAY ON TEST | 3| 3| 3| 8| 7| 6| 3| 6| 1| 8| | |
| 5| 5| 5| 9| 2| 4| 5| 3| 9| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
0.3% MF | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Leukemia Mononuclear, Marked | X X | 5 |
Leukemia Mononuclear, Moderate | | 5 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 7 |
__________________________________________________________________________|____________|
Harderian Gland | | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|
| 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X X X X |
Leukemia Mononuclear, Moderate | X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pharynx | + |
Palate, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Moderate | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|
| 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + M + + + M + + + + M + M M + + +|
Adenoma | X X X |
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X |
Polyp Stromal | X X X X|
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear, | |
Marked | |
Mediastinal, Leukemia Mononuclear, | |
Moderate | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + I + + + M + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X X X X |
Leukemia Mononuclear, Moderate | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X X X X |
Leukemia Mononuclear, Moderate | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|
| 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X X X X |
Leukemia Mononuclear, Moderate | X X X X X X X |
Sarcoma | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + M M + + + + + + M + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X X X X X X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + M + + + + + + + +|
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X X X X |
Leukemia Mononuclear, Moderate | X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + |
__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 4| 7| 4| 7| 2| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 4| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 6| 1| 6| 2| 6| 2| 4| 3| 7| 0| 9| 4| 3| 3| 4| 8| 1| 6| 3| 3| 3| 5|
| 9| 9| 9| 2| 4| 3| 9| 4| 9| 5| 1| 8| 8| 3| 0| 1| 0| 0| 5| 9| 4| 2| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|
| 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% HF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | X X X X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + M + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pharynx | |
Palate, Squamous Cell Papilloma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Moderate | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + M + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + M + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + M + M + + + |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M M + + + + + + + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|
| 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% HF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + M + M + |
Adenoma | X X |
Carcinoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | |
Polyp Stromal | X X X X |
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear, | |
Marked | X |
Mediastinal, Leukemia Mononuclear, | |
Moderate | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M M + + M + + + |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | X X X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|
| 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% HF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | X X X X |
Sarcoma | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + M + M + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + M M + M + + |
Adenocarcinoma | X |
Fibroadenoma | X X X X X X X X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Skin | + + + + M + + + + + + + + + + + + + + |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Astrocytoma Malignant | |
Carcinoma, Metastatic, Pituitary | |
Gland | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 7| 6| 4| 7| 7| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 3| 2| 6| 3| 3| 3| 1| 7| 6| 3| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 7| 6|
| 2| 3| 2| 8| 3| 2| 1| 9| 1| 1| 3| 2| 4| 2| 2| 0| 0| 3| 0| 0| 0| 0| 0| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.6% HF | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 5| 5| 3| 3| | |
DAY ON TEST | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0| | |
| 0| 0| 4| 9| 8| 0| 5| 4| 4| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
Leukemia Mononuclear, Marked | X | 7 |
Leukemia Mononuclear, Moderate | X X X | 14 |
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Leukemia Mononuclear, Moderate | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
Leukemia Mononuclear, Marked | | 3 |
Leukemia Mononuclear, Moderate | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 5| 5| 3| 3| | |
DAY ON TEST | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0| | |
| 0| 0| 4| 9| 8| 0| 5| 4| 4| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 47 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M M | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 3 |
Pars Distalis, Adenoma | | 24 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | X X | 7 |
C-Cell, Carcinoma | X | 1 |
Follicular Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + | 40 |
Adenoma | | 5 |
Carcinoma | X X | 2 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + M | 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
Leukemia Mononuclear, Marked | | 1 |
Polyp Stromal | X X | 10 |
__________________________________________________________________________|____________|
Vagina | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 29 |
Leukemia Mononuclear, Marked | | 1 |
Leukemia Mononuclear, Moderate | X | 8 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Mediastinal, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear, | | |
Marked | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 5| 5| 3| 3| | |
DAY ON TEST | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0| | |
| 0| 0| 4| 9| 8| 0| 5| 4| 4| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Leukemia Mononuclear, | | |
Moderate | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M | 44 |
Leukemia Mononuclear | X | 3 |
Leukemia Mononuclear, Marked | X | 6 |
Leukemia Mononuclear, Moderate | X | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
Leukemia Mononuclear, Marked | X | 7 |
Leukemia Mononuclear, Moderate | X | 11 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
Leukemia Mononuclear, Marked | X | 7 |
Leukemia Mononuclear, Moderate | X X X | 14 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M | 42 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + M M | 43 |
Adenocarcinoma | X | 2 |
Fibroadenoma | X | 18 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 48 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Astrocytoma Malignant | | 1 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 6| 5| 5| 3| 3| | |
DAY ON TEST | 3| 3| 6| 2| 6| 9| 8| 5| 5| 0| | |
| 0| 0| 4| 9| 8| 0| 5| 4| 4| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
0.6% HF | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear | X | 3 |
Leukemia Mononuclear, Marked | X | 7 |
Leukemia Mononuclear, Moderate | X X | 12 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 9 |
__________________________________________________________________________|____________|
Harderian Gland | | 5 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
Renal Tubule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|
| 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X X X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + + + I +|
Leukemia Mononuclear, Marked | |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X|
Bilateral, Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M I|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|
| 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X |
Bilateral, Interstitial Cell, | |
Carcinoma | |
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + I + + + |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mediastinal, Leukemia Mononuclear | X X |
Mediastinal, Leukemia Mononuclear, | |
Marked | X X |
Mediastinal, Leukemia Mononuclear, | |
Moderate | |
Pancreatic, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear, | |
Marked | X X |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|
| 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X X X |
Leukemia Mononuclear, Moderate | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X X X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X X X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X X X |
__________________________________________________________________________|
Thymus | + + + + M + + + M + + M + + + + + M + + +|
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + M + M M M M + + + + M +|
Fibroadenoma | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Keratoacanthoma | X |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X X |
Subcutaneous Tissue, Fibroma | X X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Thyroid Gland | X |
Hemangiosarcoma, Metastatic, Spleen | |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 5| 7| 7| 6| 6| 4| 7| 4| 4| 7| 6| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 6| 6| 7| 6| 3| 3| 6| 5| 6| 3| 6| 6| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 1| 0|
| 8| 4| 1| 9| 8| 6| 6| 1| 2| 4| 8| 4| 5| 8| 5| 8| 8| 6| 0| 2| 8| 8| 6| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Leukemia Mononuclear, Marked | X X X X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|
| 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Mild | X X X |
Leukemia Mononuclear, Moderate | X X X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + I + + M M I + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
Pheochromocytoma Malignant | X|
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + I + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|
| 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + +|
Adenoma | |
Carcinoma | X X|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + M + + + M + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X|
Bilateral, Interstitial Cell, | |
Carcinoma | X |
Interstitial Cell, Adenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Mild | X X X |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear, | |
Marked | X X |
Mediastinal, Leukemia Mononuclear, | |
Moderate | |
Pancreatic, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear, | |
Marked | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|
| 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Mild | X X X |
Leukemia Mononuclear, Moderate | X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + M M + + + + M + M + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + M + + + + + + M + + M + M M|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Keratoacanthoma | X X |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Carcinoma, Metastatic, Thyroid Gland | |
Hemangiosarcoma, Metastatic, Spleen | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 4| 6| 3| 3| 3| 3| 1| 3| 3| 1| 4| 6| 3| 3| 6| 3| 3|
| 6| 6| 6| 1| 4| 8| 8| 8| 0| 4| 6| 6| 2| 2| 2| 8| 7| 8| 1| 8| 8| 8| 4| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Moderate | X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Renal Tubule, Adenoma | X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 4| 7| 6| 4| 4| | |
DAY ON TEST | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6| | |
| 4| 6| 6| 5| 3| 4| 4| 2| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + + + + | 49 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
Leukemia Mononuclear, Marked | X | 8 |
Leukemia Mononuclear, Mild | X | 5 |
Leukemia Mononuclear, Moderate | X | 11 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
__________________________________________________________________________|____________|
Pancreas | + M + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Leukemia Mononuclear, Marked | | 2 |
Leukemia Mononuclear, Moderate | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 44 |
Leukemia Mononuclear, Marked | | 1 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X | 11 |
Bilateral, Pheochromocytoma Benign | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 4| 7| 6| 4| 4| | |
DAY ON TEST | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6| | |
| 4| 6| 6| 5| 3| 4| 4| 2| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + | 49 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | I + + + M + | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + I + + M | 48 |
Pars Distalis, Adenoma | X | 16 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
C-Cell, Adenoma | X X | 4 |
C-Cell, Carcinoma | | 3 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + M + + + + | 48 |
Adenoma | X | 2 |
Carcinoma | | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + | 47 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
Mesothelioma Malignant | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X | 29 |
Bilateral, Interstitial Cell, | | |
Carcinoma | | 1 |
Interstitial Cell, Adenoma | X X | 13 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 25 |
Leukemia Mononuclear, Marked | | 1 |
Leukemia Mononuclear, Mild | X | 5 |
Leukemia Mononuclear, Moderate | | 5 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Leukemia Mononuclear, Marked | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 4| 7| 6| 4| 4| | |
DAY ON TEST | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6| | |
| 4| 6| 6| 5| 3| 4| 4| 2| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Mediastinal, Leukemia Mononuclear | | 2 |
Mediastinal, Leukemia Mononuclear, | | |
Marked | | 4 |
Mediastinal, Leukemia Mononuclear, | | |
Moderate | X | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear, | | |
Marked | X | 3 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 47 |
Leukemia Mononuclear | | 3 |
Leukemia Mononuclear, Marked | X | 8 |
Leukemia Mononuclear, Moderate | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + | 49 |
Leukemia Mononuclear | | 3 |
Leukemia Mononuclear, Marked | | 6 |
Leukemia Mononuclear, Moderate | X | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Hemangiosarcoma | X | 2 |
Leukemia Mononuclear | | 3 |
Leukemia Mononuclear, Marked | X | 8 |
Leukemia Mononuclear, Mild | X | 5 |
Leukemia Mononuclear, Moderate | X | 11 |
__________________________________________________________________________|____________|
Thymus | + + + M + + | 40 |
Leukemia Mononuclear | | 3 |
Leukemia Mononuclear, Marked | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + | 36 |
Fibroadenoma | | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 50 |
Basal Cell Adenoma | X | 1 |
Keratoacanthoma | | 3 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 2 |
Subcutaneous Tissue, Fibroma | | 6 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 4| 7| 6| 4| 4| | |
DAY ON TEST | 6| 3| 3| 6| 0| 6| 1| 8| 6| 6| | |
| 4| 6| 6| 5| 3| 4| 4| 2| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 49 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Hemangiosarcoma, Metastatic, Spleen | X | 1 |
Leukemia Mononuclear | | 3 |
Leukemia Mononuclear, Marked | X | 8 |
Leukemia Mononuclear, Moderate | X | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 49 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Renal Tubule, Adenoma | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|
| 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + +|
Mesothelioma Benign | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + +|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X X X |
__________________________________________________________________________|
Mesentery | + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X X |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|
| 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X |
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Mediastinal, Leukemia Mononuclear, | |
Marked | X X X |
Mediastinal, Leukemia Mononuclear, | |
Moderate | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|
| 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Leukemia Mononuclear, | |
Marked | |
Pancreatic, Leukemia Mononuclear, | |
Moderate | X |
Renal, Leukemia Mononuclear, Moderate| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X X X |
Sarcoma | X |
__________________________________________________________________________|
Thymus | + + + + M + + M M M + + + + + + + + M +|
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + M + M + M M +|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Leukemia Mononuclear, Marked | X |
Subcutaneous Tissue, Fibroma | X X X |
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X|
Alveolar/Bronchiolar Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 6| 4| 4| 7| 7| 6| 6| 6| 7| 7| 4| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 6| 2| 3| 3| 8| 6| 6| 3| 3| 1| 1| 0| 3| 2| 6| 5| 8| 3| 3| 3| 3| 3|
| 5| 2| 2| 5| 5| 5| 3| 7| 4| 5| 5| 5| 9| 3| 3| 5| 3| 5| 2| 5| 7| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Moderate | X X X X |
Pheochromocytoma Malignant, | |
Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Carcinoma, Metastatic, Harderian | |
Gland | |
__________________________________________________________________________|
Harderian Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + +|
Leukemia Mononuclear, Marked | X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|
| 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.06% LM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + |
Mesothelioma Malignant | X X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear, Marked | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | X |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + I + + + + +|
Leukemia Mononuclear, Marked | X X |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|
| 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.06% LM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X X X|
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + +|
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + I + + + + + M + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X X X X|
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Prostate | + + + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + M + + + + + + + + + + + +|
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Mediastinal, Leukemia Mononuclear, | |
Marked | X X |
Mediastinal, Leukemia Mononuclear, | |
Moderate | X X|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|
| 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.06% LM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Leukemia Mononuclear, | |
Marked | |
Pancreatic, Leukemia Mononuclear, | |
Moderate | |
Renal, Leukemia Mononuclear, Moderate| X|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + M + +|
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Moderate | X X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X X X X X X X X|
Sarcoma | |
__________________________________________________________________________|
Thymus | M + M M + + + + + M + M + + + + + M + + +|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M M M + M + + + + + + + + + + M + +|
Fibroadenoma | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Leukemia Mononuclear, Marked | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 4| 6| 6| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 6| 9| 7| 6| 3| 3| 8| 6| 0| 3| 3| 1| 1| 7| 3| 3| 7| 6| 6| 3| 3| 3| 0| 4|
| 7| 5| 2| 1| 4| 7| 7| 7| 9| 6| 8| 8| 8| 5| 9| 5| 5| 0| 4| 4| 2| 2| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.06% LM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Moderate | X X X X X X X X X|
Pheochromocytoma Malignant, | |
Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Carcinoma, Metastatic, Harderian | |
Gland | X |
__________________________________________________________________________|
Harderian Gland | + + + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | X |
Mesothelioma Malignant | X X X |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3| | |
| 8| 4| 3| 8| 4| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 49 |
Mesothelioma Benign | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + M + + + + + | 47 |
Mesothelioma Benign | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 48 |
Leukemia Mononuclear, Marked | | 1 |
Leukemia Mononuclear, Moderate | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear, Marked | X | 7 |
Leukemia Mononuclear, Mild | | 2 |
Leukemia Mononuclear, Moderate | X X X | 16 |
__________________________________________________________________________|____________|
Mesentery | + + + | 9 |
Mesothelioma Malignant | X | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 49 |
Leukemia Mononuclear, Marked | | 2 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Leukemia Mononuclear, Marked | | 1 |
Leukemia Mononuclear, Moderate | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3| | |
| 8| 4| 3| 8| 4| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Adenoma | X | 1 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Leukemia Mononuclear, Marked | | 4 |
Pheochromocytoma Malignant | X X | 2 |
Pheochromocytoma Benign | X X | 17 |
Bilateral, Pheochromocytoma Benign | X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 49 |
Adenoma | X X | 4 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 49 |
Pars Distalis, Adenoma | X X X X X | 27 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
C-Cell, Adenoma | X X X | 8 |
C-Cell, Carcinoma | X | 3 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 50 |
Mesothelioma Malignant | X | 5 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 50 |
Adenoma | X X | 6 |
Carcinoma | | 6 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 49 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 49 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 50 |
Mesothelioma Malignant | | 4 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X | 36 |
Interstitial Cell, Adenoma | | 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3| | |
| 8| 4| 3| 8| 4| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 8 |
Leukemia Mononuclear, Marked | | 1 |
Leukemia Mononuclear, Moderate | X X | 7 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Mediastinal, Leukemia Mononuclear, | | |
Marked | X | 6 |
Mediastinal, Leukemia Mononuclear, | | |
Moderate | X | 3 |
Pancreatic, Leukemia Mononuclear, | | |
Marked | X | 1 |
Pancreatic, Leukemia Mononuclear, | | |
Moderate | | 1 |
Renal, Leukemia Mononuclear, Moderate| | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + I | 45 |
Leukemia Mononuclear, Marked | X | 5 |
Leukemia Mononuclear, Moderate | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 50 |
Leukemia Mononuclear, Marked | X | 7 |
Leukemia Mononuclear, Moderate | X X X | 15 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Hemangiosarcoma | | 1 |
Leukemia Mononuclear, Marked | X | 7 |
Leukemia Mononuclear, Mild | X | 3 |
Leukemia Mononuclear, Moderate | X X X | 16 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + + + M + + | 37 |
Leukemia Mononuclear, Marked | | 1 |
Leukemia Mononuclear, Moderate | | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M + M M M | 34 |
Fibroadenoma | X X | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Keratoacanthoma | | 2 |
Leukemia Mononuclear, Marked | | 1 |
Subcutaneous Tissue, Fibroma | | 4 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3| | |
| 8| 4| 3| 8| 4| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear, Marked | X | 7 |
Leukemia Mononuclear, Moderate | X X X | 16 |
Pheochromocytoma Malignant, | | |
Metastatic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 48 |
Leukemia Mononuclear, Marked | | 1 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 6| 2| 3| 2| 3| 3| 3| 3| 3| | |
| 8| 4| 3| 8| 4| 2| 2| 2| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.06% LM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Mesothelioma Benign | | 1 |
Mesothelioma Malignant | X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|
DAY ON TEST | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|
| 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear, Marked | X |
Liposarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Pharynx | + |
Palate, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear, Moderate | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Carcinoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + I + + + + + + |
Ganglioneuroma | X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + M + + + + + |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|
DAY ON TEST | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|
| 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + M + + + |
Adenoma | X X |
Carcinoma | X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Liposarcoma, Metastatic | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
Leukemia Mononuclear, Moderate | X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Axillary, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear, | |
Marked | X |
Pancreatic, Leukemia Mononuclear, | |
Marked | X |
Pancreatic, Leukemia Mononuclear, | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|
DAY ON TEST | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|
| 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Moderate | |
Renal, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | X X X X X X X |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + M + + + |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + M + M M + + M |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + M + + + + |
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Astrocytoma Malignant | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Adrenal Gland | |
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | X X |
Leukemia Mononuclear, Marked | X X |
Leukemia Mononuclear, Moderate | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 4| 4| 7| 7| 4| 6| 4| 7| 6| 4| 6| 4|
DAY ON TEST | 6| 3| 1| 1| 2| 3| 3| 2| 0| 6| 3| 9| 3| 8| 6| 3| 3| 6| 4| 4| 1| 3| 6| 2| 6|
| 5| 1| 5| 0| 1| 1| 1| 5| 3| 1| 1| 2| 1| 4| 5| 1| 1| 5| 2| 1| 4| 8| 5| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + M + |
Leukemia Mononuclear | X |
Leukemia Mononuclear, Moderate | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|
DAY ON TEST | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|
| 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% MM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear, Marked | |
Liposarcoma | X |
__________________________________________________________________________|
Pancreas | + M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pharynx | |
Palate, Squamous Cell Papilloma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + M + +|
Leukemia Mononuclear, Moderate | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Ganglioneuroma | |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|
DAY ON TEST | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|
| 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% MM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Liposarcoma, Metastatic | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear, | |
Marked | X |
Pancreatic, Leukemia Mononuclear, | |
Marked | |
Pancreatic, Leukemia Mononuclear, | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|
DAY ON TEST | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|
| 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% MM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Moderate | |
Renal, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X X X X X |
__________________________________________________________________________|
Thymus | + M M + + + + + + + + M + M + M + M + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Moderate | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M + + + M M + M + + + M + + +|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + M + + + + + + +|
Keratoacanthoma | |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Adrenal Gland | X |
Carcinoma, Metastatic, Zymbal's Gland| X |
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 4| 7| 4| 6| 6| 6| 4| 6| 5|
DAY ON TEST | 3| 0| 5| 6| 7| 6| 3| 3| 3| 2| 3| 3| 3| 1| 2| 3| 6| 3| 6| 4| 9| 7| 6| 2| 8|
| 1| 3| 5| 5| 8| 4| 2| 2| 2| 4| 3| 3| 3| 9| 7| 2| 5| 2| 5| 8| 8| 0| 5| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% MM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + +|
__________________________________________________________________________|
Harderian Gland | + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + + + |
Carcinoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Moderate | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6| | |
| 2| 2| 2| 2| 1| 2| 2| 2| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | | 3 |
Leukemia Mononuclear, Marked | | 3 |
Leukemia Mononuclear, Moderate | X X X X | 18 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
Leukemia Mononuclear, Marked | | 1 |
Liposarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 47 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + M M + + + + + + | 46 |
Leukemia Mononuclear, Moderate | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6| | |
| 2| 2| 2| 2| 1| 2| 2| 2| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Ganglioneuroma | | 1 |
Pheochromocytoma Malignant | X X | 2 |
Pheochromocytoma Benign | X X X X | 13 |
Bilateral, Pheochromocytoma Benign | | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 46 |
Adenoma | X | 2 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X | 19 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
C-Cell, Adenoma | X | 1 |
C-Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 49 |
Adenoma | | 2 |
Carcinoma | | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Liposarcoma, Metastatic | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X | 35 |
Interstitial Cell, Adenoma | X | 13 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 10 |
Leukemia Mononuclear, Moderate | X | 10 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6| | |
| 2| 2| 2| 2| 1| 2| 2| 2| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Axillary, Leukemia Mononuclear | | 1 |
Inguinal, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 2 |
Mediastinal, Leukemia Mononuclear, | | |
Marked | | 2 |
Pancreatic, Leukemia Mononuclear, | | |
Marked | | 1 |
Pancreatic, Leukemia Mononuclear, | | |
Moderate | X | 1 |
Renal, Leukemia Mononuclear | | 2 |
Renal, Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 3 |
Leukemia Mononuclear, Marked | | 3 |
Leukemia Mononuclear, Moderate | X X X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
Leukemia Mononuclear, Marked | | 3 |
Leukemia Mononuclear, Moderate | X X X X | 17 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
Leukemia Mononuclear, Marked | | 3 |
Leukemia Mononuclear, Moderate | X X X X | 18 |
__________________________________________________________________________|____________|
Thymus | + + M + + M + + + + | 40 |
Leukemia Mononuclear | | 3 |
Leukemia Mononuclear, Marked | | 1 |
Leukemia Mononuclear, Moderate | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + M + M + + + M | 35 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 48 |
Keratoacanthoma | X | 2 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 6| | |
| 2| 2| 2| 2| 1| 2| 2| 2| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% MM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Astrocytoma Malignant | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Carcinoma, Metastatic, Adrenal Gland | | 1 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
Leukemia Mononuclear | | 2 |
Leukemia Mononuclear, Marked | | 3 |
Leukemia Mononuclear, Moderate | X X X X | 18 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 11 |
__________________________________________________________________________|____________|
Harderian Gland | I + | 9 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 4 |
Carcinoma | X | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
Renal Tubule, Adenoma | X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + M | 47 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Moderate | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|
DAY ON TEST | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|
| 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + +|
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X |
Acinus, Adenoma | X |
Acinus, Carcinoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|
DAY ON TEST | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|
| 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M M + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X X X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + I + + + + + I + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X|
Pars Distalis, Carcinoma | X |
Pars Nervosa, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, C-Cell, Carcinoma | |
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + M + + +|
Adenoma | X |
Carcinoma | X |
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + |
Leukemia Mononuclear, Marked | |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X |
__________________________________________________________________________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|
DAY ON TEST | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|
| 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear, | |
Marked | |
Mediastinal, Leukemia Mononuclear, | |
Moderate | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + M M + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + M +|
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Thymus | + + M + + + M + + + + + + + M + + M + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M + + + M M M M M + + + + + M + +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Basal Cell Carcinoma | |
Keratoacanthoma | X |
Leukemia Mononuclear | |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibrosarcoma | X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Osteoma | X |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 4| 7| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 4| 6| 5|
DAY ON TEST | 6| 2| 2| 0| 6| 6| 2| 5| 9| 8| 2| 2| 2| 1| 9| 2| 2| 1| 0| 9| 6| 2| 6| 4| 7|
| 4| 9| 9| 4| 4| 5| 9| 7| 1| 5| 9| 9| 9| 9| 5| 9| 9| 8| 1| 5| 5| 9| 5| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Glioma Malignant | |
Granular Cell Tumor NOS | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | |
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Moderate | X X X X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Eye | + +|
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Hamartoma | X |
Leukemia Mononuclear | |
Lipoma | X |
Renal Tubule, Adenoma | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + A + + + + + + + + +|
Leukemia Mononuclear, Moderate | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|
| 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + +|
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Mild | |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
Acinus, Adenoma | |
Acinus, Carcinoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|
| 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X|
Pars Distalis, Carcinoma | |
Pars Nervosa, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bilateral, C-Cell, Carcinoma | |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + M + + + + M + + + +|
Adenoma | X X X X |
Carcinoma | X X X X |
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + I + + +|
Leukemia Mononuclear, Marked | X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|
| 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear, | |
Marked | X |
Mediastinal, Leukemia Mononuclear, | |
Moderate | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + M + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Moderate | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Mild | X |
Leukemia Mononuclear, Moderate | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + M + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + M + + + + + + + + + + M + + + + +|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Basal Cell Carcinoma | |
Keratoacanthoma | |
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Osteoma | |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 7| 6| 5| 5| 3| 7| 7| 5| 5| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 6| 7| 3| 3| 5| 2| 4| 3| 1| 7| 6| 0| 3| 3| 8| 3| 4| 3| 6| 3| 3| 3|
| 1| 1| 4| 9| 9| 1| 0| 4| 3| 4| 1| 3| 7| 4| 5| 0| 0| 6| 3| 2| 0| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% HM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + M + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
Glioma Malignant | X |
Granular Cell Tumor NOS | X|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
Leukemia Mononuclear, Marked | X X X |
Leukemia Mononuclear, Moderate | X X X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | X |
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + + + + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Hamartoma | |
Leukemia Mononuclear | X |
Lipoma | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + A + + + +|
Leukemia Mononuclear, Moderate | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 6| 4| 6| | |
DAY ON TEST | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0| | |
| 5| 4| 0| 4| 0| 0| 0| 9| 4| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 48 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 50 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 49 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | | 4 |
Leukemia Mononuclear, Mild | | 1 |
Leukemia Mononuclear, Moderate | X X | 13 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + M + | 47 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | | 2 |
Acinus, Adenoma | | 1 |
Acinus, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 50 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 6| 4| 6| | |
DAY ON TEST | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0| | |
| 5| 4| 0| 4| 0| 0| 0| 9| 4| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 46 |
Leukemia Mononuclear | | 1 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | X X | 16 |
Bilateral, Pheochromocytoma Benign | | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + | 48 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 48 |
Pars Distalis, Adenoma | | 19 |
Pars Distalis, Carcinoma | | 1 |
Pars Nervosa, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Bilateral, C-Cell, Carcinoma | X | 1 |
C-Cell, Adenoma | | 6 |
C-Cell, Carcinoma | X | 2 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 47 |
Adenoma | | 5 |
Carcinoma | | 5 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + | 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 92
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 6| 4| 6| | |
DAY ON TEST | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0| | |
| 5| 4| 0| 4| 0| 0| 0| 9| 4| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X | 33 |
Interstitial Cell, Adenoma | X | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + | 23 |
Leukemia Mononuclear, Marked | | 1 |
Leukemia Mononuclear, Mild | | 2 |
Leukemia Mononuclear, Moderate | X X | 5 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 49 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 49 |
Axillary, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Mediastinal, Histiocytic Sarcoma | X | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear, | | |
Marked | | 1 |
Mediastinal, Leukemia Mononuclear, | | |
Moderate | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 45 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | | 4 |
Leukemia Mononuclear, Moderate | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | | 4 |
Leukemia Mononuclear, Moderate | X X | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 2 |
Leukemia Mononuclear, Marked | | 4 |
Leukemia Mononuclear, Mild | | 2 |
Leukemia Mononuclear, Moderate | X X | 12 |
__________________________________________________________________________|____________|
Thymus | + M M + + + | 42 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 93
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 6| 4| 6| | |
DAY ON TEST | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0| | |
| 5| 4| 0| 4| 0| 0| 0| 9| 4| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M M | 36 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + M | 49 |
Basal Cell Adenoma | | 1 |
Basal Cell Carcinoma | X | 1 |
Keratoacanthoma | | 1 |
Leukemia Mononuclear | | 1 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
Osteoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 49 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Glioma Malignant | | 1 |
Granular Cell Tumor NOS | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 1 |
Leukemia Mononuclear, Marked | | 4 |
Leukemia Mononuclear, Moderate | X X | 13 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 94
NTP Experiment-Test: 05035-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4-HYDROXYACETANILIDE Date: 04/10/97
Route: DOSED FEED Time: 12:32:01
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 4| 7| 7| 7| 6| 4| 6| | |
DAY ON TEST | 6| 6| 3| 6| 3| 3| 3| 1| 6| 0| | |
| 5| 4| 0| 4| 0| 0| 0| 9| 4| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% HM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Eye | + + | 8 |
__________________________________________________________________________|____________|
Harderian Gland | + | 6 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Hamartoma | | 1 |
Leukemia Mononuclear | | 1 |
Lipoma | | 1 |
Renal Tubule, Adenoma | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 46 |
Leukemia Mononuclear, Moderate | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + | 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
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