TDMS Study 05035-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 4-HYDROXYACETANILIDE DATE: 09/05/94
EXPERIMENT: 05035 TEST: 03 TIME: 00:30:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01CP9561902 ROUTE: DOSED FEED NTP C#: 55801
PATHOLOGIST: A. RUSSFIELD S. EUSTIS CAS: 103-90-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 4-HYDROXYACETANILIDE DATE: 09/05/94
EXPERIMENT: 05035 TEST: 03 TIME: 00:30:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561902 ROUTE: DOSED FEED NTP C#: 55801
PATHOLOGIST: A. RUSSFIELD S. EUSTIS CAS: 103-90-2
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 4-HYDROXYACETANILIDE DATE: 09/05/94
EXPERIMENT: 05035 TEST: 03 TIME: 00:30:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561902 ROUTE: DOSED FEED NTP C#: 55801
PATHOLOGIST: A. RUSSFIELD S. EUSTIS CAS: 103-90-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 4-HYDROXYACETANILIDE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pancreas Carcinoma or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Skin: Subcutaneous Tissue Fibroma
Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
Testes Adenoma
All Organs Mesothelioma Benign, Malignant, NOS
Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Skin: Subcutaneous Tissue Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
Thyroid Gland: Follicular Cell
Carcinoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Malignant Tumors
====================================================================================================
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/44 (36%) 20/49 (41%) 17/49 (35%) 19/46 (41%) | 3/39 (8%) 6/47 (13%) 6/44 (14%) 4/47 (9%) |
|ADJUSTED (b) | 51.4% 54.6% 57.0% 63.0% | 12.5% 17.8% 18.4% 16.0% |
|TERMINAL (d) | 10/24 (42%) 12/28 (43%) 10/22 (45%) 12/22 (55%) | 3/24 (13%) 5/32 (16%) 4/29 (14%) 4/25 (16%) |
|FIRST INCIDENCE (DAYS) | 635 549 642 586 | 729 (T) 689 644 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.230 P=0.444 P=0.401 P=0.250 | P=0.502 P=0.389 P=0.325 P=0.523 |
|INCIDENTAL TUMOR | P=0.300 P=0.524 P=0.533N P=0.321 | P=0.558 P=0.392 P=0.288 P=0.523 |
|LOGISTIC REGRESSION | P=0.277 P=0.490 P=0.497N P=0.296 | P=0.541 P=0.399 P=0.315 P=0.523 |
|COCHRAN-ARMITAGE | P=0.443 | P=0.485N |
|FISHER EXACT | P=0.411 P=0.519N P=0.396 | P=0.344 P=0.306 P=0.605 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/44 (2%) 2/49 (4%) 2/49 (4%) 2/46 (4%) | 0/39 (0%) 1/47 (2%) 0/44 (0%) 0/47 (0%) |
|ADJUSTED (b) | 4.2% 7.1% 9.1% 7.4% | 0.0% 2.4% 0.0% 0.0% |
|TERMINAL (d) | 1/24 (4%) 2/28 (7%) 2/22 (9%) 1/22 (5%) | 0/24 (0%) 0/32 (0%) 0/29 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) 669 | --- 644 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.372 P=0.554 P=0.469 P=0.476 | P=0.469N P=0.510 (e) (e) |
|INCIDENTAL TUMOR | P=0.379 P=0.554 P=0.469 P=0.493 | P=0.401N P=0.531 (e) (e) |
|LOGISTIC REGRESSION | P=0.384 P=0.554 P=0.469 P=0.492 | P=0.416N P=0.503 (e) (e) |
|COCHRAN-ARMITAGE | P=0.444 | P=0.433N |
|FISHER EXACT | P=0.541 P=0.541 P=0.517 | P=0.547 (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/44 (39%) 22/49 (45%) 19/49 (39%) 21/46 (46%) | 3/39 (8%) 7/47 (15%) 6/44 (14%) 4/47 (9%) |
|ADJUSTED (b) | 54.9% 60.3% 64.2% 67.7% | 12.5% 19.8% 18.4% 16.0% |
|TERMINAL (d) | 11/24 (46%) 14/28 (50%) 12/22 (55%) 13/22 (59%) | 3/24 (13%) 5/32 (16%) 4/29 (14%) 4/25 (16%) |
|FIRST INCIDENCE (DAYS) | 635 549 642 586 | 729 (T) 644 644 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.175 P=0.387 P=0.317 P=0.190 | P=0.553N P=0.277 P=0.325 P=0.523 |
|INCIDENTAL TUMOR | P=0.226 P=0.456 P=0.547 P=0.242 | P=0.479N P=0.285 P=0.288 P=0.523 |
|LOGISTIC REGRESSION | P=0.208 P=0.429 P=0.513 P=0.184 | P=0.497N P=0.287 P=0.315 P=0.523 |
|COCHRAN-ARMITAGE | P=0.386 | P=0.410N |
|FISHER EXACT | P=0.345 P=0.579 P=0.323 | P=0.245 P=0.306 P=0.605 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/48 (4%) 6/50 (12%) 2/49 (4%) 5/47 (11%) | 5/43 (12%) 1/47 (2%) 6/43 (14%) 5/40 (13%) |
|ADJUSTED (b) | 6.9% 19.6% 6.4% 17.8% | 17.2% 3.0% 19.9% 18.8% |
|TERMINAL (d) | 1/25 (4%) 5/28 (18%) 1/23 (4%) 3/24 (13%) | 5/29 (17%) 1/33 (3%) 5/28 (18%) 3/22 (14%) |
|FIRST INCIDENCE (DAYS) | 682 600 521 577 | 729 (T) 729 (T) 611 640 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.346 P=0.170 P=0.671 P=0.205 | P=0.114 P=0.074N P=0.477 P=0.475 |
|INCIDENTAL TUMOR | P=0.366 P=0.163 P=0.624N P=0.215 | P=0.142 P=0.074N P=0.489 P=0.518 |
|LOGISTIC REGRESSION | P=0.376 P=0.163 P=0.682N P=0.207 | P=0.125 P=0.074N P=0.463 P=0.493 |
|COCHRAN-ARMITAGE | P=0.382 | P=0.187 |
|FISHER EXACT | P=0.148 P=0.684N P=0.209 | P=0.082N P=0.500 P=0.583 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/48 (6%) 6/50 (12%) 3/49 (6%) 5/47 (11%) | 4/43 (9%) 5/47 (11%) 3/43 (7%) 2/40 (5%) |
|ADJUSTED (b) | 12.0% 16.6% 10.0% 16.1% | 12.3% 13.9% 10.7% 6.5% |
|TERMINAL (d) | 3/25 (12%) 2/28 (7%) 1/23 (4%) 3/24 (13%) | 2/29 (7%) 3/33 (9%) 3/28 (11%) 1/22 (5%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 549 642 533 | 679 670 729 (T) 308 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.429 P=0.296 P=0.631 P=0.338 | P=0.275N P=0.574 P=0.503N P=0.426N |
|INCIDENTAL TUMOR | P=0.456 P=0.296 P=0.641 P=0.300 | P=0.136N P=0.546 P=0.600N P=0.231N |
|LOGISTIC REGRESSION | P=0.463 P=0.271 P=0.661N P=0.344 | P=0.214N P=0.570 P=0.528N P=0.297N |
|COCHRAN-ARMITAGE | P=0.462 | P=0.212N |
|FISHER EXACT | P=0.264 P=0.651N P=0.345 | P=0.557 P=0.500N P=0.373N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/48 (10%) 12/50 (24%) 5/49 (10%) 10/47 (21%) | 9/43 (21%) 6/47 (13%) 8/43 (19%) 7/40 (18%) |
|ADJUSTED (b) | 18.5% 34.1% 16.0% 32.5% | 28.5% 16.8% 26.8% 24.6% |
|TERMINAL (d) | 4/25 (16%) 7/28 (25%) 2/23 (9%) 6/24 (25%) | 7/29 (24%) 4/33 (12%) 7/28 (25%) 4/22 (18%) |
|FIRST INCIDENCE (DAYS) | 682 549 521 533 | 679 670 611 308 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.298 P=0.090 P=0.588 P=0.119 | P=0.386 P=0.209N P=0.519N P=0.579N |
|INCIDENTAL TUMOR | P=0.325 P=0.083 P=0.599N P=0.107 | P=0.549N P=0.219N P=0.576N P=0.418N |
|LOGISTIC REGRESSION | P=0.337 P=0.074 P=0.623N P=0.121 | P=0.455 P=0.199N P=0.549N P=0.482N |
|COCHRAN-ARMITAGE | P=0.340 | P=0.527 |
|FISHER EXACT | P=0.065 P=0.617N P=0.121 | P=0.225N P=0.500N P=0.454N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 4/49 (8%) 2/46 (4%) 1/48 (2%) | 1/46 (2%) 2/49 (4%) 1/48 (2%) 1/47 (2%) |
|ADJUSTED (b) | 7.7% 13.1% 7.4% 4.2% | 3.4% 5.6% 3.1% 2.4% |
|TERMINAL (d) | 2/26 (8%) 3/27 (11%) 1/22 (5%) 1/24 (4%) | 1/29 (3%) 1/34 (3%) 1/32 (3%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 613 661 729 (T) | 729 (T) 694 729 (T) 611 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.249N P=0.353 P=0.643 P=0.528N | P=0.517N P=0.550 P=0.740N P=0.755 |
|INCIDENTAL TUMOR | P=0.242N P=0.335 P=0.649 P=0.528N | P=0.489N P=0.504 P=0.740N P=0.718N |
|LOGISTIC REGRESSION | P=0.237N P=0.357 P=0.652 P=0.528N | P=0.498N P=0.539 P=0.740N P=0.758N |
|COCHRAN-ARMITAGE | P=0.216N | P=0.478N |
|FISHER EXACT | P=0.339 P=0.667 P=0.508N | P=0.524 P=0.742N P=0.747N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 5/49 (10%) 3/46 (7%) 1/48 (2%) | 1/46 (2%) 2/49 (4%) 1/48 (2%) 1/47 (2%) |
|ADJUSTED (b) | 7.7% 15.7% 11.8% 4.2% | 3.4% 5.6% 3.1% 2.4% |
|TERMINAL (d) | 2/26 (8%) 3/27 (11%) 2/22 (9%) 1/24 (4%) | 1/29 (3%) 1/34 (3%) 1/32 (3%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 613 661 729 (T) | 729 (T) 694 729 (T) 611 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.226N P=0.234 P=0.434 P=0.528N | P=0.517N P=0.550 P=0.740N P=0.755 |
|INCIDENTAL TUMOR | P=0.221N P=0.228 P=0.439 P=0.528N | P=0.489N P=0.504 P=0.740N P=0.718N |
|LOGISTIC REGRESSION | P=0.215N P=0.232 P=0.443 P=0.528N | P=0.498N P=0.539 P=0.740N P=0.758N |
|COCHRAN-ARMITAGE | P=0.194N | P=0.478N |
|FISHER EXACT | P=0.218 P=0.470 P=0.508N | P=0.524 P=0.742N P=0.747N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 3/50 (6%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 11.1% 0.0% 13.0% 12.5% | 0.0% 0.0% 0.0% 2.9% |
|TERMINAL (d) | 3/27 (11%) 0/28 (0%) 3/23 (13%) 3/24 (13%) | 0/30 (0%) 0/34 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) 729 (T) | --- --- --- 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.220 P=0.113N P=0.589 P=0.610 | P=0.170 (e) (e) P=0.483 |
|INCIDENTAL TUMOR | P=0.220 P=0.113N P=0.589 P=0.610 | P=0.192 (e) (e) P=0.477 |
|LOGISTIC REGRESSION | P=0.220 P=0.113N P=0.589 P=0.610 | P=0.190 (e) (e) P=0.501 |
|COCHRAN-ARMITAGE | P=0.287 | P=0.186 |
|FISHER EXACT | P=0.121N P=0.661N P=0.661N | (e) (e) P=0.500 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 2/50 (4%) 3/50 (6%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 7.4% 5.9% 7.5% 8.7% | 2.4% 2.9% 0.0% 0.0% |
|TERMINAL (d) | 2/27 (7%) 1/28 (4%) 1/23 (4%) 1/24 (4%) | 0/30 (0%) 1/34 (3%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 635 703 585 | 607 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.324 P=0.682N P=0.644 P=0.457 | P=0.217N P=0.739N P=0.505N P=0.500N |
|INCIDENTAL TUMOR | P=0.368 P=0.686 P=0.675 P=0.484 | P=0.201N P=0.747N P=0.531N P=0.450N |
|LOGISTIC REGRESSION | P=0.373 P=0.683N P=0.673 P=0.503 | P=0.201N P=0.750 P=0.500N P=0.472N |
|COCHRAN-ARMITAGE | P=0.381 | P=0.208N |
|FISHER EXACT | P=0.691N P=0.691N P=0.500 | P=0.753N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 2/50 (4%) 4/50 (8%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 7.4% 9.4% 7.5% 12.7% | 2.4% 2.9% 0.0% 3.6% |
|TERMINAL (d) | 2/27 (7%) 2/28 (7%) 1/23 (4%) 2/24 (8%) | 0/30 (0%) 1/34 (3%) 0/34 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 635 703 585 | 607 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.245 P=0.516 P=0.644 P=0.295 | P=0.611N P=0.739N P=0.505N P=0.753 |
|INCIDENTAL TUMOR | P=0.281 P=0.495 P=0.675 P=0.315 | P=0.584N P=0.747N P=0.531N P=0.741N |
|LOGISTIC REGRESSION | P=0.285 P=0.520 P=0.673 P=0.331 | P=0.594N P=0.750 P=0.500N P=0.762N |
|COCHRAN-ARMITAGE | P=0.304 | P=0.588N |
|FISHER EXACT | P=0.500 P=0.691N P=0.339 | P=0.753N P=0.500N P=0.753N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 2.9% 2.9% 5.5% |
|TERMINAL (d) | 0/27 (0%) 0/28 (0%) 0/23 (0%) 0/24 (0%) | 0/30 (0%) 1/34 (3%) 1/34 (3%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 729 (T) 729 (T) 611 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.148 P=0.525 P=0.525 P=0.235 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.170 P=0.525 P=0.525 P=0.254 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.161 P=0.525 P=0.525 P=0.245 |
|COCHRAN-ARMITAGE | (e) | P=0.168 |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.500 P=0.247 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 5/50 (10%) 1/50 (2%) 1/50 (2%) | 19/50 (38%) 24/50 (48%) 20/50 (40%) 18/50 (36%) |
|ADJUSTED (b) | 14.8% 15.9% 3.8% 3.1% | 47.8% 61.0% 52.0% 52.9% |
|TERMINAL (d) | 4/27 (15%) 3/28 (11%) 0/23 (0%) 0/24 (0%) | 10/30 (33%) 19/34 (56%) 16/34 (47%) 13/28 (46%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 670 715 695 | 517 576 506 471 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.067N P=0.535 P=0.225N P=0.209N | P=0.426N P=0.384 P=0.514N P=0.555 |
|INCIDENTAL TUMOR | P=0.054N P=0.543 P=0.202N P=0.203N | P=0.372N P=0.239 P=0.420 P=0.524 |
|LOGISTIC REGRESSION | P=0.056N P=0.545 P=0.201N P=0.197N | P=0.338N P=0.261 P=0.507 P=0.540N |
|COCHRAN-ARMITAGE | P=0.045N* | P=0.261N |
|FISHER EXACT | P=0.500 P=0.181N P=0.181N | P=0.210 P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 5/50 (10%) 1/50 (2%) 1/50 (2%) | 19/50 (38%) 24/50 (48%) 20/50 (40%) 20/50 (40%) |
|ADJUSTED (b) | 14.8% 15.9% 3.8% 3.1% | 47.8% 61.0% 52.0% 55.5% |
|TERMINAL (d) | 4/27 (15%) 3/28 (11%) 0/23 (0%) 0/24 (0%) | 10/30 (33%) 19/34 (56%) 16/34 (47%) 13/28 (46%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 670 715 695 | 517 576 506 471 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.067N P=0.535 P=0.225N P=0.209N | P=0.473 P=0.384 P=0.514N P=0.407 |
|INCIDENTAL TUMOR | P=0.054N P=0.543 P=0.202N P=0.203N | P=0.529 P=0.239 P=0.420 P=0.368 |
|LOGISTIC REGRESSION | P=0.056N P=0.545 P=0.201N P=0.197N | P=0.509N P=0.261 P=0.507 P=0.463 |
|COCHRAN-ARMITAGE | P=0.045N* | P=0.421N |
|FISHER EXACT | P=0.500 P=0.181N P=0.181N | P=0.210 P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Pancreas |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/49 (0%) 0/47 (0%) 2/47 (4%) | 0/47 (0%) 0/49 (0%) 0/49 (0%) 0/48 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 8.3% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/27 (0%) 0/22 (0%) 2/24 (8%) | 0/30 (0%) 0/34 (0%) 0/33 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 729 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.038 * (e) (e) P=0.220 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.038 * (e) (e) P=0.220 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.038 * (e) (e) P=0.220 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.040 * | (e) |
|FISHER EXACT | (e) (e) P=0.237 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/48 (33%) 27/49 (55%) 19/49 (39%) 19/48 (40%) | 23/47 (49%) 31/50 (62%) 27/50 (54%) 24/49 (49%) |
|ADJUSTED (b) | 45.0% 62.0% 56.7% 51.7% | 60.5% 71.3% 66.9% 68.9% |
|TERMINAL (d) | 9/27 (33%) 12/28 (43%) 10/23 (43%) 8/24 (33%) | 14/28 (50%) 22/34 (65%) 21/34 (62%) 17/27 (63%) |
|FIRST INCIDENCE (DAYS) | 568 549 582 564 | 517 501 456 471 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.479 P=0.068 P=0.227 P=0.262 | P=0.531 P=0.309 P=0.540 P=0.435 |
|INCIDENTAL TUMOR | P=0.443N P=0.026 * P=0.271 P=0.293 | P=0.445N P=0.185 P=0.379 P=0.436 |
|LOGISTIC REGRESSION | P=0.414N P=0.025 * P=0.337 P=0.314 | P=0.374N P=0.152 P=0.387 P=0.522 |
|COCHRAN-ARMITAGE | P=0.374N | P=0.296N |
|FISHER EXACT | P=0.025 * P=0.365 P=0.336 | P=0.138 P=0.384 P=0.579 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/48 (2%) 0/49 (0%) 0/49 (0%) 1/48 (2%) | 1/47 (2%) 0/50 (0%) 2/50 (4%) 1/49 (2%) |
|ADJUSTED (b) | 2.1% 0.0% 0.0% 4.2% | 3.6% 0.0% 5.9% 3.7% |
|TERMINAL (d) | 0/27 (0%) 0/28 (0%) 0/23 (0%) 1/24 (4%) | 1/28 (4%) 0/34 (0%) 2/34 (6%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | 568 --- --- 729 (T) | 729 (T) --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.512 P=0.500N P=0.517N P=0.743 | P=0.390 P=0.461N P=0.568 P=0.754 |
|INCIDENTAL TUMOR | P=0.535 P=0.540N P=0.540N P=0.757 | P=0.390 P=0.461N P=0.568 P=0.754 |
|LOGISTIC REGRESSION | P=0.577 P=0.486N P=0.366N P=0.740N | P=0.390 P=0.461N P=0.568 P=0.754 |
|COCHRAN-ARMITAGE | P=0.535 | P=0.430 |
|FISHER EXACT | P=0.495N P=0.495N P=0.753N | P=0.485N P=0.523 P=0.742N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/48 (35%) 27/49 (55%) 19/49 (39%) 20/48 (42%) | 24/47 (51%) 31/50 (62%) 29/50 (58%) 25/49 (51%) |
|ADJUSTED (b) | 46.2% 62.0% 56.7% 54.7% | 63.4% 71.3% 72.0% 72.0% |
|TERMINAL (d) | 9/27 (33%) 12/28 (43%) 10/23 (43%) 9/24 (38%) | 15/28 (54%) 22/34 (65%) 23/34 (68%) 18/27 (67%) |
|FIRST INCIDENCE (DAYS) | 568 549 582 564 | 517 501 456 471 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.450 P=0.096 P=0.288 P=0.262 | P=0.469 P=0.379 P=0.489 P=0.432 |
|INCIDENTAL TUMOR | P=0.473N P=0.039 * P=0.338 P=0.293 | P=0.514N P=0.250 P=0.323 P=0.433 |
|LOGISTIC REGRESSION | P=0.438N P=0.039 * P=0.429 P=0.323 | P=0.442N P=0.210 P=0.316 P=0.519 |
|COCHRAN-ARMITAGE | P=0.403N | P=0.346N |
|FISHER EXACT | P=0.040 * P=0.448 P=0.338 | P=0.189 P=0.315 P=0.579N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 7.2% 7.1% 6.6% 3.1% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 2/28 (7%) 1/23 (4%) 0/24 (0%) | 0/30 (0%) 0/34 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 631 729 (T) 620 695 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.291N P=0.493N P=0.530N P=0.333N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.240N P=0.549N P=0.591N P=0.271N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.238N P=0.517N P=0.468N P=0.275N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.246N | (e) |
|FISHER EXACT | P=0.500N P=0.500N P=0.309N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 6.4% 0.0% 0.0% 7.2% | 0.0% 2.9% 2.9% 3.6% |
|TERMINAL (d) | 1/27 (4%) 0/28 (0%) 0/23 (0%) 1/24 (4%) | 0/30 (0%) 1/34 (3%) 1/34 (3%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 661 --- --- 695 | --- 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.388 P=0.227N P=0.264N P=0.663 | P=0.381 P=0.525 P=0.525 P=0.486 |
|INCIDENTAL TUMOR | P=0.404 P=0.216N P=0.227N P=0.691 | P=0.381 P=0.525 P=0.525 P=0.486 |
|LOGISTIC REGRESSION | P=0.403 P=0.234N P=0.243N P=0.679 | P=0.381 P=0.525 P=0.525 P=0.486 |
|COCHRAN-ARMITAGE | P=0.424 | P=0.412 |
|FISHER EXACT | P=0.247N P=0.247N P=0.691N | P=0.500 P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 6.4% 0.0% 0.0% 4.2% | 0.0% 2.9% 2.9% 3.6% |
|TERMINAL (d) | 1/27 (4%) 0/28 (0%) 0/23 (0%) 1/24 (4%) | 0/30 (0%) 1/34 (3%) 1/34 (3%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 661 --- --- 729 (T) | --- 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.570N P=0.227N P=0.264N P=0.537N | P=0.381 P=0.525 P=0.525 P=0.486 |
|INCIDENTAL TUMOR | P=0.555N P=0.216N P=0.227N P=0.516N | P=0.381 P=0.525 P=0.525 P=0.486 |
|LOGISTIC REGRESSION | P=0.550N P=0.234N P=0.243N P=0.517N | P=0.381 P=0.525 P=0.525 P=0.486 |
|COCHRAN-ARMITAGE | P=0.529N | P=0.412 |
|FISHER EXACT | P=0.247N P=0.247N P=0.500N | P=0.500 P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.1% 0.0% 0.0% 8.3% | 2.4% 2.9% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/28 (0%) 0/23 (0%) 2/24 (8%) | 0/30 (0%) 1/34 (3%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 703 --- --- 729 (T) | 607 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.180 P=0.494N P=0.513N P=0.461 | P=0.217N P=0.739N P=0.505N P=0.500N |
|INCIDENTAL TUMOR | P=0.189 P=0.464N P=0.448N P=0.484 | P=0.201N P=0.747N P=0.531N P=0.450N |
|LOGISTIC REGRESSION | P=0.186 P=0.494N P=0.508N P=0.478 | P=0.201N P=0.750 P=0.500N P=0.472N |
|COCHRAN-ARMITAGE | P=0.208 | P=0.208N |
|FISHER EXACT | P=0.500N P=0.500N P=0.500 | P=0.753N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 2/50 (4%) 2/50 (4%) 5/50 (10%) | 1/50 (2%) 2/50 (4%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 15.8% 7.1% 6.6% 18.0% | 2.4% 5.9% 2.9% 3.6% |
|TERMINAL (d) | 1/27 (4%) 2/28 (7%) 1/23 (4%) 3/24 (13%) | 0/30 (0%) 2/34 (6%) 1/34 (3%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 631 729 (T) 620 695 | 607 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.438 P=0.134N P=0.170N P=0.557N | P=0.509N P=0.537 P=0.749N P=0.753 |
|INCIDENTAL TUMOR | P=0.501 P=0.141N P=0.156N P=0.489N | P=0.489N P=0.529 P=0.758 P=0.741N |
|LOGISTIC REGRESSION | P=0.491 P=0.139N P=0.125N P=0.596N | P=0.499N P=0.500 P=0.762 P=0.762N |
|COCHRAN-ARMITAGE | P=0.514 | P=0.477N |
|FISHER EXACT | P=0.134N P=0.134N P=0.500N | P=0.500 P=0.753N P=0.753N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 4/50 (8%) 2/50 (4%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 15.1% 11.5% 5.8% 0.0% | 6.7% 5.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 2/28 (7%) 0/23 (0%) 0/24 (0%) | 2/30 (7%) 1/34 (3%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 514 613 655 --- | 729 (T) 562 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.015N* P=0.348N P=0.165N P=0.025N* | P=0.076N P=0.656N P=0.211N P=0.253N |
|INCIDENTAL TUMOR | P=0.006N** P=0.399N P=0.067N P=0.014N* | P=0.071N P=0.660N P=0.211N P=0.253N |
|LOGISTIC REGRESSION | P=0.005N** P=0.421N P=0.102N P=0.010N* | P=0.071N P=0.695 P=0.211N P=0.253N |
|COCHRAN-ARMITAGE | P=0.009N** | P=0.070N |
|FISHER EXACT | P=0.370N P=0.134N P=0.013N* | P=0.691N P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 4.0% 2.2% | 5.3% 0.0% 0.0% 6.6% |
|TERMINAL (d) | 0/27 (0%) 0/28 (0%) 0/23 (0%) 0/24 (0%) | 1/30 (3%) 0/34 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 719 577 | 396 --- --- 690 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.198 (e) P=0.485 P=0.500 | P=0.394 P=0.224N P=0.226N P=0.670 |
|INCIDENTAL TUMOR | P=0.228 (e) P=0.552 P=0.517 | P=0.383 P=0.298N P=0.183N P=0.605 |
|LOGISTIC REGRESSION | P=0.229 (e) P=0.488 P=0.576 | P=0.482 P=0.353N P=0.233N P=0.669N |
|COCHRAN-ARMITAGE | P=0.208 | P=0.424 |
|FISHER EXACT | (e) P=0.500 P=0.500 | P=0.247N P=0.247N P=0.691N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 5/50 (10%) 3/50 (6%) 1/50 (2%) | 4/50 (8%) 2/50 (4%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 15.1% 14.9% 9.6% 2.2% | 11.8% 5.0% 0.0% 6.6% |
|TERMINAL (d) | 0/27 (0%) 3/28 (11%) 0/23 (0%) 0/24 (0%) | 3/30 (10%) 1/34 (3%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 514 613 655 577 | 396 562 --- 690 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.049N* P=0.470N P=0.283N P=0.076N | P=0.278N P=0.297N P=0.053N P=0.369N |
|INCIDENTAL TUMOR | P=0.023N* P=0.527N P=0.132N P=0.046N* | P=0.273N P=0.350N P=0.042N* P=0.426N |
|LOGISTIC REGRESSION | P=0.021N* P=0.548N P=0.205N P=0.033N* | P=0.220N P=0.406N P=0.062N P=0.329N |
|COCHRAN-ARMITAGE | P=0.030N* | P=0.246N |
|FISHER EXACT | P=0.500N P=0.243N P=0.056N | P=0.339N P=0.059N P=0.339N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 1/50 (2%) 1/50 (2%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 3.6% 4.0% 2.2% | 5.3% 0.0% 0.0% 6.6% |
|TERMINAL (d) | 0/27 (0%) 1/28 (4%) 0/23 (0%) 0/24 (0%) | 1/30 (3%) 0/34 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 719 577 | 396 --- --- 690 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.386 P=0.507 P=0.485 P=0.500 | P=0.394 P=0.224N P=0.226N P=0.670 |
|INCIDENTAL TUMOR | P=0.417 P=0.507 P=0.552 P=0.517 | P=0.383 P=0.298N P=0.183N P=0.605 |
|LOGISTIC REGRESSION | P=0.418 P=0.507 P=0.488 P=0.576 | P=0.482 P=0.353N P=0.233N P=0.669N |
|COCHRAN-ARMITAGE | P=0.412 | P=0.424 |
|FISHER EXACT | P=0.500 P=0.500 P=0.500 | P=0.247N P=0.247N P=0.691N |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.3% 2.9% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/28 (0%) 0/23 (0%) 0/24 (0%) | 0/30 (0%) 0/34 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 612 692 --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.115N P=0.489N P=0.249N P=0.264N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.095N P=0.481N P=0.232N P=0.220N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.098N P=0.516N P=0.224N P=0.223N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.105N | (e) |
|FISHER EXACT | P=0.500N P=0.247N P=0.247N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 42/50 (84%) 45/50 (90%) 48/50 (96%) 42/50 (84%) | |
|ADJUSTED (b) | 97.6% 95.7% 100.0% 97.5% | |
|TERMINAL (d) | 26/27 (96%) 26/28 (93%) 23/23 (100%) 23/24 (96%) | |
|FIRST INCIDENCE (DAYS) | 514 506 441 442 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.200 P=0.509 P=0.063 P=0.314 | |
|INCIDENTAL TUMOR | P=0.426 P=0.373 P=0.039 * P=0.451 | |
|LOGISTIC REGRESSION | P=0.469 P=0.351 P=0.023 * P=0.493 | |
|COCHRAN-ARMITAGE | P=0.489N | |
|FISHER EXACT | P=0.277 P=0.046 * P=0.607N | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 8/50 (16%) 1/50 (2%) 6/50 (12%) | 9/49 (18%) 5/50 (10%) 6/50 (12%) 7/50 (14%) |
|ADJUSTED (b) | 13.3% 25.6% 4.3% 18.4% | 24.7% 12.7% 17.6% 23.7% |
|TERMINAL (d) | 2/27 (7%) 6/28 (21%) 1/23 (4%) 2/24 (8%) | 5/30 (17%) 2/34 (6%) 6/34 (18%) 6/28 (21%) |
|FIRST INCIDENCE (DAYS) | 682 619 729 (T) 533 | 578 618 729 (T) 662 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.538 P=0.210 P=0.219N P=0.332 | P=0.527 P=0.155N P=0.231N P=0.450N |
|INCIDENTAL TUMOR | P=0.519N P=0.206 P=0.177N P=0.370 | P=0.515N P=0.166N P=0.275N P=0.393N |
|LOGISTIC REGRESSION | P=0.527N P=0.200 P=0.194N P=0.361 | P=0.531N P=0.187N P=0.268N P=0.407N |
|COCHRAN-ARMITAGE | P=0.488N | P=0.478N |
|FISHER EXACT | P=0.178 P=0.181N P=0.370 | P=0.183N P=0.274N P=0.376N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 1/50 (2%) 2/50 (4%) | 1/49 (2%) 3/50 (6%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 11.1% 10.7% 4.3% 5.5% | 3.3% 8.0% 8.6% 2.9% |
|TERMINAL (d) | 3/27 (11%) 3/28 (11%) 1/23 (4%) 0/24 (0%) | 1/30 (3%) 2/34 (6%) 2/34 (6%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) 606 | 729 (T) 626 718 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.377N P=0.649N P=0.362N P=0.540N | P=0.490N P=0.349 P=0.352 P=0.743 |
|INCIDENTAL TUMOR | P=0.361N P=0.649N P=0.362N P=0.515N | P=0.463N P=0.340 P=0.278 P=0.753 |
|LOGISTIC REGRESSION | P=0.352N P=0.649N P=0.362N P=0.517N | P=0.470N P=0.326 P=0.336 P=0.759 |
|COCHRAN-ARMITAGE | P=0.317N | P=0.439N |
|FISHER EXACT | P=0.661N P=0.309N P=0.500N | P=0.316 P=0.316 P=0.747N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 11/50 (22%) 2/50 (4%) 8/50 (16%) | 10/49 (20%) 8/50 (16%) 9/50 (18%) 8/50 (16%) |
|ADJUSTED (b) | 23.7% 35.7% 8.7% 23.0% | 27.7% 20.0% 25.7% 25.9% |
|TERMINAL (d) | 5/27 (19%) 9/28 (32%) 2/23 (9%) 2/24 (8%) | 6/30 (20%) 4/34 (12%) 8/34 (24%) 6/28 (21%) |
|FIRST INCIDENCE (DAYS) | 682 619 729 (T) 533 | 578 618 718 662 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.445N P=0.252 P=0.117N P=0.438 | P=0.518N P=0.317N P=0.409N P=0.461N |
|INCIDENTAL TUMOR | P=0.381N P=0.248 P=0.095N P=0.490 | P=0.448N P=0.345N P=0.502N P=0.401N |
|LOGISTIC REGRESSION | P=0.383N P=0.256 P=0.092N P=0.482 | P=0.464N P=0.378N P=0.471N P=0.413N |
|COCHRAN-ARMITAGE | P=0.330N | P=0.403N |
|FISHER EXACT | P=0.218 P=0.080N P=0.500 | P=0.379N P=0.480N P=0.379N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 2.5% 0.0% 0.0% 4.2% | 0.0% 0.0% 0.0% 6.0% |
|TERMINAL (d) | 0/27 (0%) 0/28 (0%) 0/23 (0%) 1/24 (4%) | 0/30 (0%) 0/34 (0%) 0/34 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 635 --- --- 729 (T) | --- --- --- 639 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.508 P=0.495N P=0.505N P=0.739 | P=0.037 * (e) (e) P=0.229 |
|INCIDENTAL TUMOR | P=0.535 P=0.540N P=0.540N P=0.757 | P=0.050 * (e) (e) P=0.259 |
|LOGISTIC REGRESSION | P=0.536 P=0.529N P=0.476N P=0.762 | P=0.042 * (e) (e) P=0.238 |
|COCHRAN-ARMITAGE | P=0.536 | P=0.044 * |
|FISHER EXACT | P=0.500N P=0.500N P=0.753N | (e) (e) P=0.253 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 1/50 (2%) | 0/49 (0%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 2.5% 3.4% 0.0% 4.2% | 0.0% 2.9% 0.0% 6.0% |
|TERMINAL (d) | 0/27 (0%) 0/28 (0%) 0/23 (0%) 1/24 (4%) | 0/30 (0%) 1/34 (3%) 0/34 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 635 725 --- 729 (T) | --- 729 (T) --- 639 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.625N P=0.750N P=0.505N P=0.739 | P=0.149 P=0.525 (e) P=0.229 |
|INCIDENTAL TUMOR | P=0.583N P=0.759 P=0.540N P=0.757 | P=0.171 P=0.525 (e) P=0.259 |
|LOGISTIC REGRESSION | P=0.601N P=0.759 P=0.476N P=0.762 | P=0.160 P=0.525 (e) P=0.238 |
|COCHRAN-ARMITAGE | P=0.588N | P=0.171 |
|FISHER EXACT | P=0.753N P=0.500N P=0.753N | P=0.505 (e) P=0.253 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 15/50 (30%) 12/50 (24%) 14/50 (28%) 10/50 (20%) |
|ADJUSTED (b) | | 41.9% 31.9% 34.9% 27.6% |
|TERMINAL (d) | | 10/30 (33%) 9/34 (26%) 9/34 (26%) 5/28 (18%) |
|FIRST INCIDENCE (DAYS) | | 574 627 372 554 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.313N P=0.224N P=0.394N P=0.241N |
|INCIDENTAL TUMOR | | P=0.247N P=0.282N P=0.547N P=0.176N |
|LOGISTIC REGRESSION | | P=0.239N P=0.263N P=0.497N P=0.197N |
|COCHRAN-ARMITAGE | | P=0.211N |
|FISHER EXACT | | P=0.326N P=0.500N P=0.178N |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 4/50 (8%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 10.4% 6.4% | 0.0% 0.0% 0.0% 2.1% |
|TERMINAL (d) | 0/27 (0%) 0/28 (0%) 1/23 (4%) 1/24 (4%) | 0/30 (0%) 0/34 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 471 586 | --- --- --- 354 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.066 (e) P=0.060 P=0.222 | P=0.181 (e) (e) P=0.492 |
|INCIDENTAL TUMOR | P=0.089 (e) P=0.102 P=0.236 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.137 (e) P=0.096 P=0.247 | P=0.492 (e) (e) P=0.774 |
|COCHRAN-ARMITAGE | P=0.078 | P=0.186 |
|FISHER EXACT | (e) P=0.059 P=0.247 | (e) (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.3% 6.4% 0.0% 4.2% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 1/28 (4%) 0/23 (0%) 1/24 (4%) | 0/30 (0%) 0/34 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 612 692 --- 729 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.299N P=0.680N P=0.249N P=0.539N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.269N P=0.676N P=0.232N P=0.493N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.273N P=0.692 P=0.224N P=0.502N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.263N | (e) |
|FISHER EXACT | P=0.691N P=0.247N P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.3% 6.4% 0.0% 4.2% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/27 (0%) 1/28 (4%) 0/23 (0%) 1/24 (4%) | 0/30 (0%) 0/34 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 612 692 --- 729 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.299N P=0.680N P=0.249N P=0.539N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.269N P=0.676N P=0.232N P=0.493N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.273N P=0.692 P=0.224N P=0.502N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.263N | (e) |
|FISHER EXACT | P=0.691N P=0.247N P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 27/50 (54%) 26/50 (52%) 24/50 (48%) 20/50 (40%) | 9/50 (18%) 17/50 (34%) 15/50 (30%) 24/50 (48%) |
|ADJUSTED (b) | 63.4% 64.9% 62.4% 54.5% | 26.4% 42.8% 35.1% 56.3% |
|TERMINAL (d) | 12/27 (44%) 15/28 (54%) 10/23 (43%) 9/24 (38%) | 6/30 (20%) 12/34 (35%) 8/34 (24%) 10/28 (36%) |
|FIRST INCIDENCE (DAYS) | 568 549 484 442 | 575 581 485 554 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.270N P=0.419N P=0.531N P=0.262N | P=0.003 ** P=0.116 P=0.188 P=0.003 ** |
|INCIDENTAL TUMOR | P=0.091N P=0.454N P=0.353N P=0.116N | P=0.002 ** P=0.069 P=0.123 P=0.001 ** |
|LOGISTIC REGRESSION | P=0.084N P=0.499N P=0.410N P=0.122N | P=0.003 ** P=0.070 P=0.120 P=0.001 ** |
|COCHRAN-ARMITAGE | P=0.078N | P=0.004 ** |
|FISHER EXACT | P=0.500N P=0.345N P=0.115N | P=0.055 P=0.121 P=0.001 ** |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 7.4% 13.9% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/27 (7%) 2/28 (7%) 0/23 (0%) 0/24 (0%) | 0/30 (0%) 0/34 (0%) 0/34 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 506 --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.031N* P=0.244 P=0.274N P=0.264N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.021N* P=0.208 P=0.274N P=0.264N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.022N* P=0.210 P=0.274N P=0.264N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.023N* | (e) |
|FISHER EXACT | P=0.218 P=0.247N P=0.247N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 47/50 (94%) 50/50 (100%) 50/50 (100%) 49/50 (98%) | 41/50 (82%) 44/50 (88%) 45/50 (90%) 40/50 (80%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 91.1% 91.6% 97.8% 90.7% |
|TERMINAL (d) | 27/27 (100%) 28/28 (100%) 23/23 (100%) 24/24 (100%)| 26/30 (87%) 30/34 (88%) 33/34 (97%) 24/28 (86%) |
|FIRST INCIDENCE (DAYS) | 514 506 441 442 | 517 501 372 471 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.133 P=0.517 P=0.147 P=0.214 | P=0.359 P=0.456N P=0.569 P=0.463 |
|INCIDENTAL TUMOR | P=0.056 P=0.189 P=0.087 P=0.110 | P=0.453 P=0.379 P=0.152 P=0.502 |
|LOGISTIC REGRESSION | P=0.053 P=0.171 P=0.045 * P=0.086 | P=0.522N P=0.420 P=0.174 P=0.591 |
|COCHRAN-ARMITAGE | P=0.327 | P=0.334N |
|FISHER EXACT | P=0.121 P=0.121 P=0.309 | P=0.288 P=0.194 P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 34/50 (68%) 34/50 (68%) 34/50 (68%) 35/50 (70%) | 21/50 (42%) 23/50 (46%) 21/50 (42%) 33/50 (66%) |
|ADJUSTED (b) | 78.5% 80.0% 77.6% 80.0% | 51.1% 53.1% 49.1% 69.9% |
|TERMINAL (d) | 18/27 (67%) 20/28 (71%) 14/23 (61%) 16/24 (67%) | 11/30 (37%) 14/34 (41%) 13/34 (38%) 14/28 (50%) |
|FIRST INCIDENCE (DAYS) | 568 506 471 305 | 380 581 485 245 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.217 P=0.463N P=0.362 P=0.330 | P=0.011 * P=0.543N P=0.455N P=0.028 * |
|INCIDENTAL TUMOR | P=0.490 P=0.541N P=0.555 P=0.539 | P=0.027 * P=0.392 P=0.528 P=0.034 * |
|LOGISTIC REGRESSION | P=0.491 P=0.575N P=0.580N P=0.523 | P=0.016 * P=0.401 P=0.578 P=0.017 * |
|COCHRAN-ARMITAGE | P=0.446 | P=0.011 * |
|FISHER EXACT | P=0.585N P=0.585N P=0.500 | P=0.420 P=0.580N P=0.013 * |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05035 TEST: 03 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 4-HYDROXYACETANILIDE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.06% LM 0.3% MM 0.6% HM | CONTROL 0.06% LF 0.3% MF 0.6% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 50/50 (100%) 50/50 (100%) 50/50 (100%)| 47/50 (94%) 46/50 (92%) 49/50 (98%) 46/50 (92%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 95.9% 93.9% 100.0% 92.0% |
|TERMINAL (d) | 27/27 (100%) 28/28 (100%) 23/23 (100%) 24/24 (100%)| 28/30 (93%) 31/34 (91%) 34/34 (100%) 24/28 (86%) |
|FIRST INCIDENCE (DAYS) | 514 506 441 305 | 380 501 372 245 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.148 P=0.482N P=0.227 P=0.265 | P=0.247 P=0.210N P=0.425N P=0.453 |
|INCIDENTAL TUMOR | P=0.267 P=0.638 P=0.318 P=0.500 | P=0.496N P=0.443N P=0.264 P=0.415N |
|LOGISTIC REGRESSION | P=0.095 P=0.638 P=0.247 P=0.276 | P=0.545N P=0.454N P=0.305 P=0.482N |
|COCHRAN-ARMITAGE | P=0.351 | P=0.545N |
|FISHER EXACT | P=0.500 P=0.500 P=0.500 | P=0.500N P=0.309 P=0.500N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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