TDMS Study 05037-04 Pathology Tables
NTP Experiment-Test: 05037-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97 Route: GAVAGE Time: 12:43:25 Facility: Southern Research Institute Chemical CAS #: 1825-21-4 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include 001 VEHICLE CONTROL Include 004 VEHICLE CONTROL Include 007 40 MG/KG Include 010 40 MG/KG Include 013 20 MG/KG Include 016 20 MG/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05037-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97 Route: GAVAGE Time: 12:43:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 20 MG/KG 40 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Moribund Sacrifice 17 18 29 Natural Death 8 6 5 Accidently Killed 1 Dosing Accident 1 Survivors Terminal Sacrifice 24 25 16 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (46) (23) (49) Dilatation 1 (2%) Liver (50) (50) (50) Angiectasis 1 (2%) 1 (2%) 1 (2%) Basophilic Focus 2 (4%) 1 (2%) Cytologic Alterations 1 (2%) 34 (68%) 39 (78%) Eosinophilic Focus 5 (10%) 1 (2%) 1 (2%) Eosinophilic Focus, Multiple 3 (6%) Hematopoietic Cell Proliferation 9 (18%) 6 (12%) 9 (18%) Inflammation, Subacute 1 (2%) 28 (56%) 32 (64%) Mixed Cell Focus 2 (4%) 2 (4%) Mixed Cell Focus, Multiple 5 (10%) Necrosis 1 (2%) 2 (4%) 2 (4%) Vacuolization Cytoplasmic 1 (2%) Biliary Tract, Dilatation 1 (2%) Biliary Tract, Hyperplasia 1 (2%) 16 (32%) 30 (60%) Kupffer Cell, Pigmentation 37 (74%) 48 (96%) Mesentery (25) (18) (24) Hemorrhage 1 (6%) Inflammation, Suppurative 8 (32%) 7 (39%) 8 (33%) Fat, Necrosis 14 (56%) 8 (44%) 8 (33%) Pancreas (50) (28) (50) Acinar Cell, Atrophy 4 (8%) 3 (11%) 2 (4%) Duct, Dilatation 1 (2%) 1 (4%) 2 (4%) Salivary Glands (50) (25) (49) Atrophy 1 (2%) Foreign Body 1 (2%) Stomach, Forestomach (50) (45) (50) Cyst Epithelial Inclusion 1 (2%) Foreign Body 1 (2%) Hyperplasia 12 (24%) 7 (16%) 6 (12%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05037-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97 Route: GAVAGE Time: 12:43:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 20 MG/KG 40 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (25) (50) Inflammation, Subacute 1 (2%) Mineralization 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (50) (49) Capsule, Spindle Cell, Hyperplasia 1 (2%) Adrenal Gland, Cortex (50) (50) (49) Accessory Adrenal Cortical Nodule 2 (4%) 1 (2%) Hypertrophy, Focal 1 (2%) Necrosis 1 (2%) Parathyroid Gland (47) (25) (48) Cyst 1 (4%) Pituitary Gland (47) (49) (50) Pars Distalis, Cyst 1 (2%) Pars Distalis, Hyperplasia 12 (26%) 8 (16%) 4 (8%) Thyroid Gland (50) (50) (50) Inflammation, Subacute 1 (2%) Follicular Cell, Hyperplasia 5 (10%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (1) (1) Duct, Cyst 1 (100%) 1 (100%) Ovary (45) (36) (50) Abscess 12 (27%) 14 (39%) 18 (36%) Cyst 3 (7%) 8 (22%) 5 (10%) Hemorrhage 3 (8%) Uterus (46) (43) (50) Dilatation 9 (20%) 4 (8%) Hyperplasia, Cystic 42 (91%) 36 (84%) 46 (92%) Inflammation, Suppurative 5 (11%) 6 (14%) 10 (20%) Mucosa, Cyst 2 (4%) 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05037-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97 Route: GAVAGE Time: 12:43:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 20 MG/KG 40 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (25) (50) Myeloid Cell, Hypercellularity 17 (34%) 11 (44%) 21 (42%) Lymph Node (50) (50) (50) Iliac, Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (4%) Iliac, Inflammation, Suppurative 1 (2%) Mediastinal, Hyperplasia, Lymphoid 1 (2%) Mediastinal, Inflammation, Suppurative 2 (4%) 1 (2%) Renal, Hyperplasia, Lymphoid 1 (2%) 1 (2%) 4 (8%) Renal, Inflammation, Suppurative 1 (2%) Lymph Node, Mandibular (49) (47) (49) Hyperplasia, Lymphoid 1 (2%) Lymph Node, Mesenteric (50) (49) (50) Angiectasis 1 (2%) 1 (2%) Hematopoietic Cell Proliferation 2 (4%) Spleen (50) (50) (50) Hematopoietic Cell Proliferation 21 (42%) 18 (36%) 28 (56%) Hyperplasia, Lymphoid 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (49) (23) (50) Hyperplasia 1 (2%) Skin (50) (26) (50) Inflammation 1 (4%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (25) (50) Hypertrophy 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (26) (50) Hemorrhage 1 (2%) Inflammation, Subacute 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (27) (50) Abscess 1 (2%) Foreign Body 1 (2%) Infiltration Cellular, Histiocyte 1 (2%) 2 (7%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05037-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97 Route: GAVAGE Time: 12:43:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 20 MG/KG 40 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Inflammation, Suppurative 1 (4%) Alveolar Epithelium, Hyperplasia 1 (2%) 2 (7%) Mediastinum, Inflammation, Suppurative 5 (10%) 5 (19%) 3 (6%) Nose (50) (50) (50) Foreign Body 7 (14%) 15 (30%) 19 (38%) Fungus 1 (2%) Inflammation, Suppurative 5 (10%) 13 (26%) 21 (42%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (6) (2) (4) Hyperplasia 2 (33%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (25) (50) Amyloid Deposition 2 (4%) Hydronephrosis 1 (2%) 2 (8%) Nephropathy 12 (24%) 3 (12%) 8 (16%) Cortex, Cyst 1 (2%) Glomerulus, Inflammation 2 (8%) Transitional Epithelium, Hyperplasia 1 (4%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05037-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97 Route: GAVAGE Time: 12:43:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 20 MG/KG 40 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Natural Death 2 2 Moribund Sacrifice 17 20 22 Accidently Killed 1 Dosing Accident 1 Survivors Terminal Sacrifice 30 27 27 Natural Death 1 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (23) (50) Inflammation, Suppurative 1 (2%) Intestine Large, Rectum (50) (23) (50) Inflammation, Suppurative 1 (2%) Intestine Small, Ileum (50) (22) (49) Hyperplasia 1 (5%) Liver (50) (50) (50) Angiectasis 1 (2%) 3 (6%) Basophilic Focus 5 (10%) 1 (2%) 1 (2%) Basophilic Focus, Multiple 1 (2%) Clear Cell Focus 2 (4%) 1 (2%) 2 (4%) Clear Cell Focus, Multiple 3 (6%) 3 (6%) Cytologic Alterations 50 (100%) 50 (100%) Eosinophilic Focus 8 (16%) 1 (2%) Eosinophilic Focus, Multiple 2 (4%) Fibrosis 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 2 (4%) Inflammation, Subacute 49 (98%) 49 (98%) Mixed Cell Focus 7 (14%) 4 (8%) 5 (10%) Mixed Cell Focus, Multiple 2 (4%) 11 (22%) 22 (44%) Necrosis 2 (4%) 1 (2%) Biliary Tract, Dilatation 1 (2%) 2 (4%) Biliary Tract, Fibrosis 1 (2%) Biliary Tract, Hyperplasia 47 (94%) 48 (96%) Kupffer Cell, Pigmentation 1 (2%) 50 (100%) 50 (100%) Mesentery (2) (9) (4) Hemorrhage 2 (22%) Fat, Necrosis 2 (100%) 5 (56%) 2 (50%) Pancreas (50) (23) (50) Acinar Cell, Atrophy 5 (10%) 4 (17%) 3 (6%) Duct, Dilatation 3 (6%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05037-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97 Route: GAVAGE Time: 12:43:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 20 MG/KG 40 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Stomach, Forestomach (50) (50) (50) Hyperplasia 19 (38%) 23 (46%) 24 (48%) Stomach, Glandular (50) (48) (49) Hyperplasia 1 (2%) Tooth (36) (10) (24) Dysplasia 35 (97%) 10 (100%) 23 (96%) Foreign Body 1 (3%) Inflammation, Chronic 1 (4%) Inflammation, Subacute 1 (3%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (23) (50) Inflammation, Subacute 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (50) (49) Capsule, Spindle Cell, Hyperplasia 4 (8%) 2 (4%) 3 (6%) Adrenal Gland, Cortex (50) (50) (49) Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%) Hypertrophy, Focal 9 (18%) 4 (8%) 7 (14%) Adrenal Gland, Medulla (50) (50) (48) Hyperplasia 13 (26%) 29 (60%) Hypertrophy 3 (6%) 36 (75%) Parathyroid Gland (49) (22) (50) Cyst 2 (4%) Pituitary Gland (44) (50) (47) Pars Distalis, Cyst 3 (7%) 1 (2%) 4 (9%) Pars Distalis, Hyperplasia 1 (2%) 1 (2%) Thyroid Gland (50) (49) (50) Follicular Cell, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (24) (50) Granuloma Sperm 1 (2%) Preputial Gland (22) (32) (26) Inflammation, Subacute 3 (14%) 5 (16%) 2 (8%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05037-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97 Route: GAVAGE Time: 12:43:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 20 MG/KG 40 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Duct, Cyst 20 (91%) 26 (81%) 26 (100%) Seminal Vesicle (50) (24) (50) Inflammation, Subacute 1 (4%) Testes (50) (23) (50) Atrophy 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (23) (50) Myeloid Cell, Hypercellularity 2 (4%) Lymph Node (50) (50) (50) Inguinal, Hyperplasia, Lymphoid 1 (2%) Mediastinal, Hyperplasia, Lymphoid 1 (2%) Lymph Node, Mesenteric (50) (49) (50) Angiectasis 1 (2%) Congestion 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia, Lymphoid 1 (2%) 2 (4%) 1 (2%) Thrombosis 1 (2%) Spleen (50) (50) (50) Hematopoietic Cell Proliferation 7 (14%) 8 (16%) 10 (20%) Hemorrhage 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (29) (50) Inflammation, Suppurative 1 (3%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (24) (50) Hypertrophy 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (23) (50) Hemorrhage 1 (2%) Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05037-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97 Route: GAVAGE Time: 12:43:25 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 20 MG/KG 40 MG/KG CONTROL ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (32) (50) Foreign Body 1 (3%) Hemorrhage 1 (3%) 1 (2%) Infiltration Cellular, Histiocyte 7 (14%) 3 (9%) 5 (10%) Thrombosis 1 (2%) Alveolar Epithelium, Hyperplasia 7 (14%) 4 (13%) 2 (4%) Nose (50) (50) (50) Exudate, Serous 1 (2%) Foreign Body 2 (4%) 14 (28%) 10 (20%) Inflammation, Suppurative 5 (10%) 12 (24%) 10 (20%) Mucosa, Atrophy 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (25) (50) Inflammation, Subacute 1 (4%) Nephropathy 21 (42%) 12 (48%) 17 (34%) Cortex, Cyst 4 (8%) 3 (12%) 4 (8%) Renal Tubule, Hyperplasia 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------