TDMS Study 05037-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst PENTACHLOROANISOLE DATE: 09/05/94
EXPERIMENT: 05037 TEST: 04 TIME: 06:24:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NOI-ES-28024 ROUTE: GAVAGE NTP C#: 56520
PATHOLOGIST: T. MAKOVEC S. EUSTIS CAS: 1825-21-4
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst PENTACHLOROANISOLE DATE: 09/05/94
EXPERIMENT: 05037 TEST: 04 TIME: 06:24:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NOI-ES-28024 ROUTE: GAVAGE NTP C#: 56520
PATHOLOGIST: T. MAKOVEC S. EUSTIS CAS: 1825-21-4
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst PENTACHLOROANISOLE DATE: 09/05/94
EXPERIMENT: 05037 TEST: 04 TIME: 06:24:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NOI-ES-28024 ROUTE: GAVAGE NTP C#: 56520
PATHOLOGIST: T. MAKOVEC S. EUSTIS CAS: 1825-21-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF PENTACHLOROANISOLE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Liver Hemangiosarcoma
Lung Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Hemangiosarcoma
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
All Organs Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Malignant Tumors
====================================================================================================
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Adrenal Gland: Non-medullary, Non-cortical |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 0/50 (0%) 2/49 (4%) | 0/50 (0%) 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 11.5% 0.0% 6.9% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/30 (7%) 0/27 (0%) 1/27 (4%) | 0/24 (0%) 0/25 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | 589 --- 715 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.245N P=0.069N P=0.370N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.185N P=0.084N P=0.303N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.226N P=0.063N P=0.344N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.228N | (e) |
|FISHER EXACT | P=0.059N P=0.349N | (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 4/50 (8%) 7/48 (15%) | 0/50 (0%) 1/49 (2%) 0/48 (0%) |
|ADJUSTED (b) | 0.0% 11.4% 23.3% | 0.0% 2.9% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/27 (4%) 5/27 (19%) | 0/24 (0%) 0/25 (0%) 0/15 (0%) |
|FIRST INCIDENCE (DAYS) | --- 691 691 | --- 564 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005 ** P=0.067 P=0.007 ** | P=0.707 P=0.484 (e) |
|INCIDENTAL TUMOR | P=0.003 ** P=0.125 P=0.007 ** | P=0.726 P=0.473 (e) |
|LOGISTIC REGRESSION | P=0.004 ** P=0.069 P=0.007 ** | P=0.730 P=0.499 (e) |
|COCHRAN-ARMITAGE | P=0.005 ** | P=0.725 |
|FISHER EXACT | P=0.059 P=0.005 ** | P=0.495 (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Bone |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 6.6% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/27 (4%) 0/28 (0%) | 0/24 (0%) 0/25 (0%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | --- 715 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.657 P=0.235 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.668 P=0.292 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.662 P=0.253 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.669 | (e) |
|FISHER EXACT | P=0.247 (e) | (e) (e) |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/23 (0%) 1/50 (2%) | 2/50 (4%) 0/25 (0%) 1/50 (2%) |
|ADJUSTED (b) | 3.0% 0.0% 3.6% | 8.3% 0.0% 6.3% |
|TERMINAL (d) | 0/30 (0%) 0/0 1/28 (4%) | 2/24 (8%) 0/0 1/16 (6%) |
|FIRST INCIDENCE (DAYS) | 710 --- 729 (T) | 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.633 P=0.494N P=0.742 | P=0.524N (e) P=0.642N |
|INCIDENTAL TUMOR | P=0.647 P=0.379N P=0.753 | P=0.524N (e) P=0.642N |
|LOGISTIC REGRESSION | P=0.640 P=0.669N P=0.755 | P=0.524N (e) P=0.642N |
|COCHRAN-ARMITAGE | P=0.654 | P=0.372N |
|FISHER EXACT | P=0.685N P=0.753N | P=0.441N P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 6/50 (12%) 4/50 (8%) | 3/50 (6%) 0/50 (0%) 4/50 (8%) |
|ADJUSTED (b) | 6.1% 19.4% 13.2% | 10.7% 0.0% 20.9% |
|TERMINAL (d) | 1/30 (3%) 4/27 (15%) 3/28 (11%) | 2/24 (8%) 0/25 (0%) 3/16 (19%) |
|FIRST INCIDENCE (DAYS) | 705 701 701 | 576 --- 499 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.264 P=0.126 P=0.312 | P=0.276 P=0.124N P=0.325 |
|INCIDENTAL TUMOR | P=0.261 P=0.188 P=0.317 | P=0.315 P=0.125N P=0.372 |
|LOGISTIC REGRESSION | P=0.264 P=0.160 P=0.318 | P=0.355 P=0.126N P=0.432 |
|COCHRAN-ARMITAGE | P=0.290 | P=0.406 |
|FISHER EXACT | P=0.134 P=0.339 | P=0.121N P=0.500 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 6.7% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/27 (0%) 0/28 (0%) | 0/24 (0%) 0/25 (0%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- 598 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.617 P=0.223 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.619N P=0.190 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.660 P=0.235 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.669 |
|FISHER EXACT | (e) (e) | P=0.247 (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 6/50 (12%) 4/50 (8%) | 3/50 (6%) 2/50 (4%) 4/50 (8%) |
|ADJUSTED (b) | 6.1% 19.4% 13.2% | 10.7% 6.7% 20.9% |
|TERMINAL (d) | 1/30 (3%) 4/27 (15%) 3/28 (11%) | 2/24 (8%) 0/25 (0%) 3/16 (19%) |
|FIRST INCIDENCE (DAYS) | 705 701 701 | 576 598 499 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.264 P=0.126 P=0.312 | P=0.279 P=0.516N P=0.325 |
|INCIDENTAL TUMOR | P=0.261 P=0.188 P=0.317 | P=0.360 P=0.547N P=0.372 |
|LOGISTIC REGRESSION | P=0.264 P=0.160 P=0.318 | P=0.366 P=0.512N P=0.432 |
|COCHRAN-ARMITAGE | P=0.290 | P=0.417 |
|FISHER EXACT | P=0.134 P=0.339 | P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 8/50 (16%) 10/50 (20%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.7% 20.0% 29.9% | 0.0% 0.0% 6.3% |
|TERMINAL (d) | 0/30 (0%) 1/27 (4%) 6/28 (21%) | 0/24 (0%) 0/25 (0%) 1/16 (6%) |
|FIRST INCIDENCE (DAYS) | 701 682 612 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.014 * P=0.069 P=0.015 * | P=0.211 (e) P=0.419 |
|INCIDENTAL TUMOR | P=0.010 * P=0.185 P=0.017 * | P=0.211 (e) P=0.419 |
|LOGISTIC REGRESSION | P=0.008 ** P=0.051 P=0.015 * | P=0.211 (e) P=0.419 |
|COCHRAN-ARMITAGE | P=0.014 * | P=0.269 |
|FISHER EXACT | P=0.046 * P=0.014 * | (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/50 (40%) 24/50 (48%) 14/50 (28%) | 8/50 (16%) 8/50 (16%) 12/50 (24%) |
|ADJUSTED (b) | 51.5% 65.6% 44.2% | 28.2% 29.7% 53.4% |
|TERMINAL (d) | 12/30 (40%) 15/27 (56%) 11/28 (39%) | 5/24 (21%) 7/25 (28%) 7/16 (44%) |
|FIRST INCIDENCE (DAYS) | 424 651 596 | 477 438 381 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.207N P=0.244 P=0.213N | P=0.046 * P=0.591N P=0.065 |
|INCIDENTAL TUMOR | P=0.154N P=0.368 P=0.170N | P=0.100 P=0.600 P=0.140 |
|LOGISTIC REGRESSION | P=0.126N P=0.356 P=0.142N | P=0.097 P=0.569 P=0.124 |
|COCHRAN-ARMITAGE | P=0.129N | P=0.185 |
|FISHER EXACT | P=0.273 P=0.146N | P=0.607N P=0.227 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 16/50 (32%) 12/50 (24%) | 4/50 (8%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 23.1% 38.8% 29.2% | 13.5% 7.7% 12.5% |
|TERMINAL (d) | 2/30 (7%) 5/27 (19%) 2/28 (7%) | 2/24 (8%) 1/25 (4%) 2/16 (13%) |
|FIRST INCIDENCE (DAYS) | 599 676 596 | 410 704 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.262 P=0.125 P=0.294 | P=0.378N P=0.335N P=0.498N |
|INCIDENTAL TUMOR | P=0.366 P=0.305 P=0.433 | P=0.281N P=0.380N P=0.406N |
|LOGISTIC REGRESSION | P=0.291 P=0.222 P=0.345 | P=0.303N P=0.349N P=0.387N |
|COCHRAN-ARMITAGE | P=0.281 | P=0.252N |
|FISHER EXACT | P=0.083 P=0.312 | P=0.339N P=0.339N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 16/50 (32%) 12/50 (24%) | 4/50 (8%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 23.1% 38.8% 29.2% | 13.5% 7.7% 16.7% |
|TERMINAL (d) | 2/30 (7%) 5/27 (19%) 2/28 (7%) | 2/24 (8%) 1/25 (4%) 2/16 (13%) |
|FIRST INCIDENCE (DAYS) | 599 676 596 | 410 704 702 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.262 P=0.125 P=0.294 | P=0.569N P=0.335N P=0.636 |
|INCIDENTAL TUMOR | P=0.366 P=0.305 P=0.433 | P=0.429N P=0.380N P=0.542N |
|LOGISTIC REGRESSION | P=0.291 P=0.222 P=0.345 | P=0.487N P=0.349N P=0.567N |
|COCHRAN-ARMITAGE | P=0.281 | P=0.417N |
|FISHER EXACT | P=0.083 P=0.312 | P=0.339N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 26/50 (52%) 34/50 (68%) 24/50 (48%) | 11/50 (22%) 10/50 (20%) 14/50 (28%) |
|ADJUSTED (b) | 60.1% 78.4% 58.8% | 37.1% 36.1% 63.8% |
|TERMINAL (d) | 13/30 (43%) 18/27 (67%) 12/28 (43%) | 7/24 (29%) 8/25 (32%) 9/16 (56%) |
|FIRST INCIDENCE (DAYS) | 424 651 596 | 410 438 381 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.508N P=0.122 P=0.523N | P=0.067 P=0.479N P=0.082 |
|INCIDENTAL TUMOR | P=0.329N P=0.244 P=0.342N | P=0.151 P=0.520N P=0.178 |
|LOGISTIC REGRESSION | P=0.360N P=0.115 P=0.403N | P=0.151 P=0.544N P=0.187 |
|COCHRAN-ARMITAGE | P=0.381N | P=0.277 |
|FISHER EXACT | P=0.076 P=0.421N | P=0.500N P=0.322 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 26/50 (52%) 34/50 (68%) 24/50 (48%) | 11/50 (22%) 10/50 (20%) 15/50 (30%) |
|ADJUSTED (b) | 60.1% 78.4% 58.8% | 37.1% 36.1% 65.5% |
|TERMINAL (d) | 13/30 (43%) 18/27 (67%) 12/28 (43%) | 7/24 (29%) 8/25 (32%) 9/16 (56%) |
|FIRST INCIDENCE (DAYS) | 424 651 596 | 410 438 381 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.508N P=0.122 P=0.523N | P=0.042 * P=0.479N P=0.053 |
|INCIDENTAL TUMOR | P=0.329N P=0.244 P=0.342N | P=0.108 P=0.520N P=0.133 |
|LOGISTIC REGRESSION | P=0.360N P=0.115 P=0.403N | P=0.099 P=0.544N P=0.126 |
|COCHRAN-ARMITAGE | P=0.381N | P=0.206 |
|FISHER EXACT | P=0.076 P=0.421N | P=0.500N P=0.247 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 7/32 (22%) 4/50 (8%) | 2/50 (4%) 1/27 (4%) 1/50 (2%) |
|ADJUSTED (b) | 22.0% 40.2% 13.4% | 7.9% 50.0% 6.3% |
|TERMINAL (d) | 6/30 (20%) 3/9 (33%) 3/28 (11%) | 1/24 (4%) 1/2 (50%) 1/16 (6%) |
|FIRST INCIDENCE (DAYS) | 691 682 705 | 704 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.282N P=0.125 P=0.300N | P=0.534N P=0.598 P=0.623N |
|INCIDENTAL TUMOR | P=0.263N P=0.215 P=0.293N | P=0.486N P=0.546 P=0.553N |
|LOGISTIC REGRESSION | P=0.257N P=0.231 P=0.287N | P=0.513N P=0.387 P=0.599N |
|COCHRAN-ARMITAGE | P=0.233N | P=0.387N |
|FISHER EXACT | P=0.264 P=0.262N | P=0.720N P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 5/32 (16%) 5/50 (10%) | 0/50 (0%) 1/27 (4%) 1/50 (2%) |
|ADJUSTED (b) | 18.7% 45.7% 17.9% | 0.0% 3.6% 4.2% |
|TERMINAL (d) | 5/30 (17%) 4/9 (44%) 5/28 (18%) | 0/24 (0%) 0/2 (0%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | 691 691 729 (T) | --- 661 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.494N P=0.149 P=0.548N | P=0.294 P=0.480 P=0.469 |
|INCIDENTAL TUMOR | P=0.490N P=0.194 P=0.545N | P=0.425 P=0.433 P=0.571 |
|LOGISTIC REGRESSION | P=0.483N P=0.324 P=0.541N | P=0.314 P=0.273 P=0.474 |
|COCHRAN-ARMITAGE | P=0.439N | P=0.344 |
|FISHER EXACT | P=0.438 P=0.500N | P=0.351 P=0.500 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/50 (22%) 12/32 (38%) 8/50 (16%) | 2/50 (4%) 2/27 (7%) 2/50 (4%) |
|ADJUSTED (b) | 33.4% 80.5% 27.3% | 7.9% 51.8% 10.2% |
|TERMINAL (d) | 9/30 (30%) 7/9 (78%) 7/28 (25%) | 1/24 (4%) 1/2 (50%) 1/16 (6%) |
|FIRST INCIDENCE (DAYS) | 691 682 705 | 704 661 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.348N P=0.013 * P=0.361N | P=0.448 P=0.321 P=0.579 |
|INCIDENTAL TUMOR | P=0.329N P=0.030 * P=0.352N | P=0.562 P=0.250 P=0.690 |
|LOGISTIC REGRESSION | P=0.318N P=0.066 P=0.344N | P=0.479 P=0.102 P=0.611 |
|COCHRAN-ARMITAGE | P=0.278N | P=0.593N |
|FISHER EXACT | P=0.102 P=0.306N | P=0.439 P=0.691N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Mesentery |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 4.2% 0.0% 12.5% |
|TERMINAL (d) | 0/30 (0%) 0/27 (0%) 0/28 (0%) | 1/24 (4%) 0/25 (0%) 2/16 (13%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.255 P=0.492N P=0.358 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.255 P=0.492N P=0.358 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.255 P=0.492N P=0.358 |
|COCHRAN-ARMITAGE | (e) | P=0.360 |
|FISHER EXACT | (e) (e) | P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|Mesentery |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 3.4% 6.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/27 (0%) 0/28 (0%) | 0/24 (0%) 0/25 (0%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 675 583 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.420N P=0.468 P=0.538N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.330N P=0.429 P=0.429N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.362N P=0.501 P=0.526N |
|COCHRAN-ARMITAGE | (e) | P=0.360N |
|FISHER EXACT | (e) (e) | P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 1/45 (2%) 0/36 (0%) 2/50 (4%) |
|ADJUSTED (b) | | 5.0% 0.0% 12.5% |
|TERMINAL (d) | | 1/20 (5%) 0/11 (0%) 2/16 (13%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.304 P=0.619N P=0.421 |
|INCIDENTAL TUMOR | | P=0.304 P=0.619N P=0.421 |
|LOGISTIC REGRESSION | | P=0.304 P=0.619N P=0.421 |
|COCHRAN-ARMITAGE | | P=0.396 |
|FISHER EXACT | | P=0.556N P=0.540 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/44 (0%) 0/50 (0%) 0/47 (0%) | 7/47 (15%) 5/49 (10%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 26.5% 20.0% 18.8% |
|TERMINAL (d) | 0/27 (0%) 0/27 (0%) 0/25 (0%) | 4/22 (18%) 5/25 (20%) 3/16 (19%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 674 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.224N P=0.324N P=0.300N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.163N P=0.366N P=0.200N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.178N P=0.358N P=0.232N |
|COCHRAN-ARMITAGE | (e) | P=0.101N |
|FISHER EXACT | (e) (e) | P=0.350N P=0.134N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 7.4% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 2/27 (7%) 0/28 (0%) | 0/24 (0%) 0/25 (0%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.652 P=0.215 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.652 P=0.215 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.652 P=0.215 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.669 | (e) |
|FISHER EXACT | P=0.247 (e) | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 6.0% 2.7% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/27 (0%) 0/28 (0%) | 0/24 (0%) 0/25 (0%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 410 549 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.176N P=0.509N P=0.298N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.114N P=0.554N P=0.164N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.134N P=0.492N P=0.227N |
|COCHRAN-ARMITAGE | (e) | P=0.142N |
|FISHER EXACT | (e) (e) | P=0.500N P=0.247N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 5/50 (10%) | 2/50 (4%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 9.2% 3.1% 14.9% | 8.0% 10.5% 0.0% |
|TERMINAL (d) | 1/30 (3%) 0/27 (0%) 2/28 (7%) | 1/24 (4%) 2/25 (8%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | 710 716 612 | 705 549 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.240 P=0.310N P=0.324 | P=0.289N P=0.506 P=0.330N |
|INCIDENTAL TUMOR | P=0.297 P=0.166N P=0.395 | P=0.239N P=0.469 P=0.241N |
|LOGISTIC REGRESSION | P=0.265 P=0.276N P=0.357 | P=0.241N P=0.480 P=0.295N |
|COCHRAN-ARMITAGE | P=0.264 | P=0.202N |
|FISHER EXACT | P=0.309N P=0.357 | P=0.500 P=0.247N |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 3.7% 2.1% | 0.0% 8.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/27 (4%) 0/28 (0%) | 0/24 (0%) 2/25 (8%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 596 | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.330 P=0.479 P=0.509 | P=0.592 P=0.246 (e) |
|INCIDENTAL TUMOR | P=0.446 P=0.479 P=0.662 | P=0.592 P=0.246 (e) |
|LOGISTIC REGRESSION | P=0.311 P=0.479 P=0.456 | P=0.592 P=0.246 (e) |
|COCHRAN-ARMITAGE | P=0.331 | P=0.669 |
|FISHER EXACT | P=0.500 P=0.500 | P=0.247 (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 3.7% 0.0% | 0.0% 8.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/27 (4%) 0/28 (0%) | 0/24 (0%) 2/25 (8%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.718 P=0.479 (e) | P=0.592 P=0.246 (e) |
|INCIDENTAL TUMOR | P=0.718 P=0.479 (e) | P=0.592 P=0.246 (e) |
|LOGISTIC REGRESSION | P=0.718 P=0.479 (e) | P=0.592 P=0.246 (e) |
|COCHRAN-ARMITAGE | P=0.731 | P=0.669 |
|FISHER EXACT | P=0.500 (e) | P=0.247 (e) |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | | 0.0% 6.0% 3.6% |
|TERMINAL (d) | | 0/24 (0%) 0/25 (0%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 583 612 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.305 P=0.218 P=0.461 |
|INCIDENTAL TUMOR | | P=0.358 P=0.202 P=0.500 |
|LOGISTIC REGRESSION | | P=0.365 P=0.240 P=0.500 |
|COCHRAN-ARMITAGE | | P=0.360 |
|FISHER EXACT | | P=0.247 P=0.500 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 3.3% 7.4% 0.0% | 3.2% 4.0% 3.2% |
|TERMINAL (d) | 1/30 (3%) 2/27 (7%) 0/28 (0%) | 0/24 (0%) 1/25 (4%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | 674 729 (T) 576 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.381N P=0.463 P=0.514N | P=0.564 P=0.750 P=0.709 |
|INCIDENTAL TUMOR | P=0.381N P=0.463 P=0.514N | P=0.633N P=0.728 P=0.721N |
|LOGISTIC REGRESSION | P=0.381N P=0.463 P=0.514N | P=0.618 P=0.752 P=0.760 |
|COCHRAN-ARMITAGE | P=0.360N | P=0.640 |
|FISHER EXACT | P=0.500 P=0.500N | P=0.753N P=0.753N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 8/50 (16%) 10/50 (20%) | 5/50 (10%) 3/50 (6%) 3/50 (6%) |
|ADJUSTED (b) | 11.6% 20.0% 29.9% | 17.8% 10.5% 18.8% |
|TERMINAL (d) | 1/30 (3%) 1/27 (4%) 6/28 (21%) | 3/24 (13%) 2/25 (8%) 3/16 (19%) |
|FIRST INCIDENCE (DAYS) | 701 682 612 | 410 549 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.056 P=0.215 P=0.068 | P=0.451N P=0.349N P=0.569N |
|INCIDENTAL TUMOR | P=0.052 P=0.478 P=0.079 | P=0.379N P=0.376N P=0.476N |
|LOGISTIC REGRESSION | P=0.043 * P=0.416 P=0.071 | P=0.348N P=0.370N P=0.443N |
|COCHRAN-ARMITAGE | P=0.060 | P=0.283N |
|FISHER EXACT | P=0.178 P=0.074 | P=0.357N P=0.357N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 10/50 (20%) 10/50 (20%) | 6/50 (12%) 4/50 (8%) 4/50 (8%) |
|ADJUSTED (b) | 14.7% 26.2% 29.9% | 20.4% 14.4% 21.4% |
|TERMINAL (d) | 2/30 (7%) 3/27 (11%) 6/28 (21%) | 3/24 (13%) 3/25 (12%) 3/16 (19%) |
|FIRST INCIDENCE (DAYS) | 701 682 612 | 410 549 576 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.103 P=0.155 P=0.116 | P=0.496N P=0.370N P=0.591N |
|INCIDENTAL TUMOR | P=0.105 P=0.347 P=0.136 | P=0.391N P=0.406N P=0.455N |
|LOGISTIC REGRESSION | P=0.091 P=0.159 P=0.124 | P=0.374N P=0.389N P=0.447N |
|COCHRAN-ARMITAGE | P=0.114 | P=0.303N |
|FISHER EXACT | P=0.131 P=0.131 | P=0.370N P=0.370N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 6/50 (12%) 9/50 (18%) | 8/50 (16%) 9/50 (18%) 12/50 (24%) |
|ADJUSTED (b) | 11.1% 16.8% 22.7% | 27.9% 27.8% 52.3% |
|TERMINAL (d) | 2/30 (7%) 2/27 (7%) 3/28 (11%) | 5/24 (21%) 4/25 (16%) 6/16 (38%) |
|FIRST INCIDENCE (DAYS) | 491 592 467 | 477 472 583 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.088 P=0.374 P=0.118 | P=0.060 P=0.490 P=0.065 |
|INCIDENTAL TUMOR | P=0.097 P=0.278 P=0.108 | P=0.155 P=0.435 P=0.157 |
|LOGISTIC REGRESSION | P=0.067 P=0.325 P=0.092 | P=0.105 P=0.475 P=0.103 |
|COCHRAN-ARMITAGE | P=0.088 | P=0.188 |
|FISHER EXACT | P=0.370 P=0.117 | P=0.500 P=0.227 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 6/50 (12%) 8/50 (16%) | 7/50 (14%) 9/50 (18%) 12/50 (24%) |
|ADJUSTED (b) | 11.1% 16.8% 20.9% | 26.2% 27.8% 52.3% |
|TERMINAL (d) | 2/30 (7%) 2/27 (7%) 3/28 (11%) | 5/24 (21%) 4/25 (16%) 6/16 (38%) |
|FIRST INCIDENCE (DAYS) | 491 592 467 | 674 472 583 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.137 P=0.374 P=0.175 | P=0.033 * P=0.391 P=0.036 * |
|INCIDENTAL TUMOR | P=0.131 P=0.278 P=0.140 | P=0.090 P=0.328 P=0.085 |
|LOGISTIC REGRESSION | P=0.114 P=0.325 P=0.149 | P=0.057 P=0.360 P=0.049 * |
|COCHRAN-ARMITAGE | P=0.141 | P=0.124 |
|FISHER EXACT | P=0.370 P=0.178 | P=0.393 P=0.154 |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 6.6% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/27 (4%) 0/28 (0%) | 0/24 (0%) 0/25 (0%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | --- 715 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.657 P=0.235 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.668 P=0.292 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.662 P=0.253 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.669 | (e) |
|FISHER EXACT | P=0.247 (e) | (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma or Osteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 6.6% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/27 (4%) 0/28 (0%) | 0/24 (0%) 0/25 (0%) 0/16 (0%) |
|FIRST INCIDENCE (DAYS) | --- 715 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.657 P=0.235 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.668 P=0.292 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.662 P=0.253 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.669 | (e) |
|FISHER EXACT | P=0.247 (e) | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 29/50 (58%) 36/50 (72%) 25/50 (50%) | 21/50 (42%) 19/50 (38%) 18/50 (36%) |
|ADJUSTED (b) | 70.2% 85.2% 70.9% | 62.7% 67.1% 72.2% |
|TERMINAL (d) | 18/30 (60%) 21/27 (78%) 18/28 (64%) | 12/24 (50%) 16/25 (64%) 10/16 (63%) |
|FIRST INCIDENCE (DAYS) | 424 651 596 | 477 438 381 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.388N P=0.124 P=0.402N | P=0.304 P=0.407N P=0.344 |
|INCIDENTAL TUMOR | P=0.278N P=0.220 P=0.307N | P=0.515N P=0.482N P=0.508N |
|LOGISTIC REGRESSION | P=0.236N P=0.185 P=0.272N | P=0.544N P=0.511N P=0.568N |
|COCHRAN-ARMITAGE | P=0.237N | P=0.304N |
|FISHER EXACT | P=0.104 P=0.274N | P=0.419N P=0.341N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 20 MG/KG 40 MG/KG | VEHICLE 20 MG/KG 40 MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 21/50 (42%) 30/50 (60%) 35/50 (70%) | 19/50 (38%) 20/50 (40%) 23/50 (46%) |
|ADJUSTED (b) | 50.3% 64.2% 74.2% | 57.8% 58.3% 81.3% |
|TERMINAL (d) | 10/30 (33%) 11/27 (41%) 16/28 (57%) | 11/24 (46%) 11/25 (44%) 11/16 (69%) |
|FIRST INCIDENCE (DAYS) | 491 592 467 | 81 472 571 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.013 * P=0.112 P=0.015 * | P=0.038 * P=0.498 P=0.040 * |
|INCIDENTAL TUMOR | P=0.005 ** P=0.224 P=0.006 ** | P=0.140 P=0.405 P=0.145 |
|LOGISTIC REGRESSION | P=0.007 ** P=0.067 P=0.005 ** | P=0.099 P=0.453 P=0.068 |
|COCHRAN-ARMITAGE | P=0.003 ** | P=0.239 |
|FISHER EXACT | P=0.055 P=0.004 ** | P=0.500 P=0.272 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 38/50 (76%) 47/50 (94%) 46/50 (92%) | 32/50 (64%) 31/50 (62%) 30/50 (60%) |
|ADJUSTED (b) | 80.8% 94.0% 95.8% | 86.0% 83.5% 93.6% |
|TERMINAL (d) | 21/30 (70%) 24/27 (89%) 26/28 (93%) | 19/24 (79%) 19/25 (76%) 14/16 (88%) |
|FIRST INCIDENCE (DAYS) | 424 592 467 | 81 438 381 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.071 P=0.102 P=0.085 | P=0.128 P=0.498N P=0.132 |
|INCIDENTAL TUMOR | P=0.020 * P=0.068 P=0.035 * | P=0.511 P=0.567 P=0.533 |
|LOGISTIC REGRESSION | P=0.018 * P=0.023 * P=0.035 * | P=0.374 P=0.587N P=0.339 |
|COCHRAN-ARMITAGE | P=0.012 * | P=0.379N |
|FISHER EXACT | P=0.011 * P=0.027 * | P=0.500N P=0.418N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 04 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).