TDMS Study 05037-03 Pathology Tables
NTP Experiment-Test: 05037-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 11:57:11
Facility: Southern Research Institute
Chemical CAS #: 1825-21-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 VEHICLE CONTROL
Include 004 VEHICLE CONTROL
Include 007 40 MG/KG
Include 010 40 MG/KG
Include 013 20 MG/KG
Include 016 20 MG/KG
Include 019 10 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05037-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 11:57:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 20 MG/KG 40 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund Sacrifice 17 13 4
Natural Death 4 2 2
Survivors
Terminal Sacrifice 29 35 44
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (1) (49)
Intestine Small, Ileum (50) (1) (50)
Liver (50) (50) (50)
Hepatocellular Adenoma 1 (2%)
Pancreas (50) (50)
Acinar Cell, Adenoma 2 (4%)
Pharynx (2) (1)
Squamous Cell Papilloma 1 (50%)
Stomach, Forestomach (50) (1) (50)
Sarcoma Stromal, Metastatic, Uterus 1 (100%)
Stomach, Glandular (50) (1) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (50) (50) (50)
Pheochromocytoma Benign 3 (6%) 5 (10%) 9 (18%)
Pheochromocytoma Benign, Multiple 2 (4%)
Pituitary Gland (49) (50) (50)
Pars Distalis, Adenoma 18 (37%) 21 (42%) 20 (40%)
Pars Distalis, Carcinoma 2 (4%) 2 (4%) 3 (6%)
Pars Distalis, Hamartoma 1 (2%)
Pars Intermedia, Adenoma 2 (4%) 2 (4%) 1 (2%)
Thyroid Gland (50) (2) (50)
C-Cell, Adenoma 7 (14%) 9 (18%)
C-Cell, Carcinoma 1 (2%)
Page 2
NTP Experiment-Test: 05037-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 11:57:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 20 MG/KG 40 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (8) (50)
Adenoma 5 (10%) 4 (50%) 3 (6%)
Carcinoma 3 (6%) 1 (13%) 2 (4%)
Ovary (50) (5) (50)
Granulosa Cell Tumor Malignant 2 (40%)
Uterus (50) (50) (50)
Adenoma 1 (2%)
Carcinoma In Situ 1 (2%)
Hemangioma 1 (2%)
Polyp Stromal 13 (26%) 13 (26%) 7 (14%)
Sarcoma Stromal 2 (4%) 1 (2%)
Vagina (2) (1) (3)
Carcinoma 1 (33%)
Leiomyoma 1 (50%)
Polyp 1 (33%)
Sarcoma Stromal, Metastatic, Uterus 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Lymph Node (50) (11) (50)
Renal, Fibrosarcoma, Metastatic, Skin 1 (9%)
Lymph Node, Mandibular (50) (3) (50)
Lymph Node, Mesenteric (49) (3) (50)
Spleen (50) (10) (50)
Thymus (47) (48)
Thymoma Benign 1 (2%)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05037-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 11:57:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 20 MG/KG 40 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (21) (50)
Adenoma 3 (6%)
Carcinoma 1 (2%)
Fibroadenoma 16 (33%) 10 (48%) 7 (14%)
Skin (50) (3) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (33%)
Subcutaneous Tissue, Fibrosarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Sarcoma Stromal, Metastatic, Uterus 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (4) (50)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (7) (50)
Alveolar/Bronchiolar Adenoma 1 (14%) 1 (2%)
Nose (49) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 11 (22%) 14 (28%) 9 (18%)
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05037-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 11:57:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 20 MG/KG 40 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Lymphocytic 1 (2%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05037-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 11:57:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 20 MG/KG 40 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 41 41
Total Primary Neoplasms 98 82 80
Total Animals with Benign Neoplasms 40 35 35
Total Benign Neoplasms 75 60 62
Total Animals with Malignant Neoplasms 22 20 18
Total Malignant Neoplasms 23 22 18
Total Animals with Metastatic Neoplasms 1 2
Total Metastatic Neoplasm 1 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05037-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 11:57:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 10 MG/KG 20 MG/KG 40 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 23 21 14 5
Natural Death 3 5 7 27
Dosing Accident 4 2
Accidently Killed 5 2
Survivors
Terminal Sacrifice 24 20 24 14
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (49) (48) (50)
Intestine Large, Colon (50) (50) (49) (49)
Intestine Large, Rectum (50) (50) (49) (47)
Intestine Small, Duodenum (50) (50) (49) (49)
Intestine Small, Ileum (50) (50) (47) (50)
Intestine Small, Jejunum (50) (50) (47) (50)
Adenoma 1 (2%)
Liver (50) (50) (50) (50)
Carcinoma, Metastatic, Stomach 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Mesentery (11) (11) (5) (9)
Leiomyosarcoma, Metastatic, Spleen 1 (9%)
Liposarcoma 1 (9%)
Pancreas (49) (49) (49) (50)
Carcinoma, Metastatic, Stomach 1 (2%)
Acinar Cell, Adenoma 12 (24%) 1 (2%) 1 (2%)
Pharynx (1) (2) (1)
Squamous Cell Carcinoma 1 (50%)
Squamous Cell Papilloma 1 (100%) 1 (100%)
Salivary Glands (50) (50) (48) (50)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50) (50) (50)
Carcinoma 1 (2%) 1 (2%)
Tongue (1) (2) (4) (2)
Squamous Cell Carcinoma 1 (25%)
Squamous Cell Papilloma 1 (50%) 1 (50%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05037-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 11:57:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 10 MG/KG 20 MG/KG 40 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49) (50)
Schwannoma Benign 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50) (50) (50)
Adrenal Gland, Medulla (50) (50) (50) (48)
Pheochromocytoma Malignant 3 (6%) 2 (4%) 3 (6%)
Pheochromocytoma Malignant, Multiple 1 (2%)
Pheochromocytoma Benign 11 (22%) 12 (24%) 13 (26%) 6 (13%)
Pheochromocytoma Benign, Multiple 1 (2%) 5 (10%) 10 (20%) 9 (19%)
Islets, Pancreatic (49) (49) (49) (50)
Adenoma 8 (16%) 2 (4%) 3 (6%) 6 (12%)
Carcinoma 1 (2%)
Parathyroid Gland (49) (50) (49) (50)
Adenoma 1 (2%)
Pituitary Gland (49) (50) (48) (50)
Pars Distalis, Adenoma 16 (33%) 22 (44%) 14 (29%) 10 (20%)
Pars Distalis, Carcinoma 4 (8%) 1 (2%) 1 (2%)
Pars Nervosa, Neoplasm NOS 1 (2%)
Thyroid Gland (50) (50) (49) (50)
C-Cell, Adenoma 12 (24%) 6 (12%) 7 (14%) 5 (10%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (3)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (50) (48) (50) (50)
Adenoma 2 (4%) 1 (2%) 5 (10%)
Carcinoma 6 (12%) 2 (4%) 1 (2%) 1 (2%)
Prostate (50) (50) (50) (50)
Carcinoma, Metastatic, Stomach 1 (2%)
Seminal Vesicle (50) (50) (49) (50)
Testes (50) (50) (50) (50)
Interstitial Cell, Adenoma 46 (92%) 45 (90%) 42 (84%) 24 (48%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05037-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 11:57:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 10 MG/KG 20 MG/KG 40 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Lymph Node (50) (50) (50) (50)
Bronchial, Carcinoma, Metastatic, Stomach 1 (2%)
Mediastinal, Carcinoma, Metastatic, Stomach 1 (2%)
Lymph Node, Mandibular (50) (49) (49) (49)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lymph Node, Mesenteric (50) (50) (49) (48)
Spleen (50) (49) (50) (50)
Carcinoma, Metastatic, Stomach 1 (2%)
Leiomyosarcoma 1 (2%)
Thymus (46) (47) (47) (47)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (49) (50) (47)
Carcinoma 1 (2%)
Fibroadenoma 6 (13%) 9 (18%) 2 (4%) 1 (2%)
Skin (50) (49) (50) (50)
Basal Cell Carcinoma 2 (4%) 2 (4%)
Carcinosarcoma 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%)
Squamous Cell Carcinoma 2 (4%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Trichoepithelioma 1 (2%)
Sebaceous Gland, Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%) 3 (6%)
Subcutaneous Tissue, Myxosarcoma 1 (2%)
Subcutaneous Tissue, Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Squamous Cell Carcinoma, Metastatic, Pharynx 1 (2%)
Skeletal Muscle (1)
Fibroma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05037-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 11:57:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 10 MG/KG 20 MG/KG 40 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 5 (10%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Stomach 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Mediastinum, Hemangiosarcoma 1 (2%)
Nose (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Urinary Bladder (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 23 (46%) 22 (44%) 15 (30%) 8 (16%)
Mesothelioma Benign 1 (2%)
Mesothelioma Malignant 3 (6%) 4 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05037-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 11:57:11
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 10 MG/KG 20 MG/KG 40 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 45 26
Total Primary Neoplasms 182 154 136 79
Total Animals with Benign Neoplasms 49 49 45 26
Total Benign Neoplasms 127 117 104 66
Total Animals with Malignant Neoplasms 39 33 28 11
Total Malignant Neoplasms 55 36 32 13
Total Animals with Metastatic Neoplasms 4 1 3
Total Metastatic Neoplasm 5 1 8
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------