TDMS Study 05037-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst PENTACHLOROANISOLE DATE: 09/05/94
EXPERIMENT: 05037 TEST: 03 TIME: 04:41:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NOI-ES-28024 ROUTE: GAVAGE NTP C#: 56520
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 1825-21-4
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst PENTACHLOROANISOLE DATE: 09/05/94
EXPERIMENT: 05037 TEST: 03 TIME: 04:41:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NOI-ES-28024 ROUTE: GAVAGE NTP C#: 56520
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 1825-21-4
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst PENTACHLOROANISOLE DATE: 09/05/94
EXPERIMENT: 05037 TEST: 03 TIME: 04:41:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NOI-ES-28024 ROUTE: GAVAGE NTP C#: 56520
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 1825-21-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF PENTACHLOROANISOLE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Carcinoma
Carcinoma or Adenoma
Heart Schwannoma Benign
Islets, Pancreatic Carcinoma or Adenoma
Lung Alveolar/Bronchiolar Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pancreas Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma
Carcinoma or Adenoma
Testes Adenoma
Thyroid Gland: C-Cell Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst PENTACHLOROANISOLE DATE: 09/05/94
EXPERIMENT: 05037 TEST: 03 TIME: 04:41:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NOI-ES-28024 ROUTE: GAVAGE NTP C#: 56520
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 1825-21-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF PENTACHLOROANISOLE
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Mammary Gland Adenoma
Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Ovary Granulosa Cell Tumor Malignant
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
Uterus Polyp Stromal
Sarcoma Stromal or Polyp Stromal
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 17/50 (34%) 23/50 (46%) 15/48 (31%) | 3/50 (6%) 7/50 (14%) 9/50 (18%) |
|ADJUSTED (b) | 37.4% 61.9% 73.6% 70.8% | 10.0% 19.1% 19.5% |
|TERMINAL (d) | 6/24 (25%) 10/20 (50%) 16/24 (67%) 8/14 (57%) | 2/29 (7%) 6/35 (17%) 7/44 (16%) |
|FIRST INCIDENCE (DAYS) | 527 520 684 548 | 718 673 712 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.010 ** P=0.077 P=0.020 * P=0.015 * | P=0.193 P=0.247 P=0.219 |
|INCIDENTAL TUMOR | P<0.001 ** P=0.063 P=0.006 ** P=0.003 ** | P=0.091 P=0.251 P=0.080 |
|LOGISTIC REGRESSION | P=0.001 ** P=0.070 P=0.006 ** P=0.004 ** | P=0.135 P=0.232 P=0.170 |
|COCHRAN-ARMITAGE | P=0.256 | P=0.049 * |
|FISHER EXACT | P=0.189 P=0.018 * P=0.282 | P=0.159 P=0.061 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 4/50 (8%) 0/48 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.2% 7.8% 14.7% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 1/20 (5%) 2/24 (8%) 0/14 (0%) | 0/29 (0%) 0/35 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 624 626 704 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.282N P=0.603N P=0.491 P=0.260N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.352N P=0.476N P=0.386 P=0.294N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.292N P=0.509N P=0.457 P=0.218N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.147N | (e) |
|FISHER EXACT | P=0.500N P=0.500 P=0.129N | (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/50 (30%) 18/50 (36%) 25/50 (50%) 15/48 (31%) | 3/50 (6%) 7/50 (14%) 9/50 (18%) |
|ADJUSTED (b) | 42.6% 65.7% 77.7% 70.8% | 10.0% 19.1% 19.5% |
|TERMINAL (d) | 6/24 (25%) 11/20 (55%) 17/24 (71%) 8/14 (57%) | 2/29 (7%) 6/35 (17%) 7/44 (16%) |
|FIRST INCIDENCE (DAYS) | 527 520 684 548 | 718 673 712 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.033 * P=0.148 P=0.042 * P=0.054 | P=0.193 P=0.247 P=0.219 |
|INCIDENTAL TUMOR | P=0.003 ** P=0.140 P=0.010 ** P=0.013 * | P=0.091 P=0.251 P=0.080 |
|LOGISTIC REGRESSION | P=0.005 ** P=0.156 P=0.010 ** P=0.021 * | P=0.135 P=0.232 P=0.170 |
|COCHRAN-ARMITAGE | P=0.457 | P=0.049 * |
|FISHER EXACT | P=0.335 P=0.033 * P=0.534 | P=0.159 P=0.061 |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) | 2/50 (4%) 0/4 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 3.3% 0.0% | 4.6% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/20 (0%) 0/24 (0%) 0/14 (0%) | 0/29 (0%) 0/1 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 704 --- | 444 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.628 (e) P=0.500 (e) | P=0.084N P=0.224N P=0.213N |
|INCIDENTAL TUMOR | P=0.584 (e) P=0.446 (e) | P=0.397N (e) P=0.570N |
|LOGISTIC REGRESSION | P=0.626 (e) P=0.484 (e) | P=0.244N P=0.739N P=0.458N |
|COCHRAN-ARMITAGE | P=0.688 | P=0.138N |
|FISHER EXACT | (e) P=0.500 (e) | P=0.856N P=0.247N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/48 (2%) 5/50 (10%) 0/50 (0%) | 5/50 (10%) 4/8 (50%) 3/50 (6%) |
|ADJUSTED (b) | 8.3% 2.6% 20.8% 0.0% | 15.8% 57.1% 6.8% |
|TERMINAL (d) | 2/24 (8%) 0/19 (0%) 5/24 (21%) 0/14 (0%) | 4/29 (14%) 4/7 (57%) 3/44 (7%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 578 729 (T) --- | 579 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.498N P=0.573N P=0.209 P=0.362N | P=0.119N P=0.101 P=0.177N |
|INCIDENTAL TUMOR | P=0.504N P=0.468N P=0.209 P=0.362N | P=0.166N P=0.026 * P=0.240N |
|LOGISTIC REGRESSION | P=0.536N P=0.532N P=0.209 P=0.362N | P=0.203N P=0.025 * P=0.276N |
|COCHRAN-ARMITAGE | P=0.312N | P=0.321N |
|FISHER EXACT | P=0.515N P=0.218 P=0.247N | P=0.015 * P=0.357N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 2/48 (4%) 1/50 (2%) 1/50 (2%) | 3/50 (6%) 1/8 (13%) 2/50 (4%) |
|ADJUSTED (b) | 17.2% 5.1% 4.2% 6.3% | 9.5% 2.6% 4.3% |
|TERMINAL (d) | 1/24 (4%) 0/19 (0%) 1/24 (4%) 0/14 (0%) | 1/29 (3%) 0/7 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 507 577 729 (T) 702 | 705 702 712 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.095N P=0.236N P=0.072N P=0.254N | P=0.251N P=0.372N P=0.320N |
|INCIDENTAL TUMOR | P=0.110N P=0.124N P=0.066N P=0.275N | P=0.471 P=0.544 P=0.633 |
|LOGISTIC REGRESSION | P=0.060N P=0.129N P=0.066N P=0.184N | P=0.484N P=0.841 P=0.593N |
|COCHRAN-ARMITAGE | P=0.030N* | P=0.416N |
|FISHER EXACT | P=0.148N P=0.056N P=0.056N | P=0.457 P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 3/48 (6%) 6/50 (12%) 1/50 (2%) | 8/50 (16%) 5/8 (63%) 5/50 (10%) |
|ADJUSTED (b) | 24.4% 7.5% 25.0% 6.3% | 24.2% 58.3% 10.8% |
|TERMINAL (d) | 3/24 (13%) 0/19 (0%) 6/24 (25%) 0/14 (0%) | 5/29 (17%) 4/7 (57%) 3/44 (7%) |
|FIRST INCIDENCE (DAYS) | 507 577 729 (T) 702 | 579 702 712 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120N P=0.204N P=0.406N P=0.133N | P=0.066N P=0.334 P=0.094N |
|INCIDENTAL TUMOR | P=0.138N P=0.087N P=0.408N P=0.140N | P=0.255N P=0.019 * P=0.322N |
|LOGISTIC REGRESSION | P=0.107N P=0.101N P=0.452N P=0.100N | P=0.137N P=0.022 * P=0.177N |
|COCHRAN-ARMITAGE | P=0.026N* | P=0.255N |
|FISHER EXACT | P=0.113N P=0.387N P=0.015N* | P=0.010 * P=0.277N |
|=================================================================================================================================|
| |
|Heart |
| Schwannoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 0/49 (0%) 0/50 (0%) | 0/50 (0%) 0/0 (0%) 0/50 (0%) |
|ADJUSTED (b) | 12.5% 5.0% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/24 (13%) 1/20 (5%) 0/23 (0%) 0/14 (0%) | 0/29 (0%) 0/0 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.066N P=0.370N P=0.126N P=0.228N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.066N P=0.370N P=0.126N P=0.228N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.066N P=0.370N P=0.126N P=0.228N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.043N* | (e) |
|FISHER EXACT | P=0.309N P=0.125N P=0.121N | (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/49 (16%) 2/49 (4%) 3/49 (6%) 6/50 (12%) | 0/50 (0%) 0/0 (0%) 0/50 (0%) |
|ADJUSTED (b) | 25.0% 7.3% 11.2% 32.5% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/24 (13%) 0/20 (0%) 2/24 (8%) 3/14 (21%) | 0/29 (0%) 0/0 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 594 604 701 514 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.316 P=0.105N P=0.122N P=0.375 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.239 P=0.069N P=0.147N P=0.320 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.299 P=0.059N P=0.122N P=0.385 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.464N | (e) |
|FISHER EXACT | P=0.046N* P=0.100N P=0.371N | (e) (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/49 (18%) 2/49 (4%) 3/49 (6%) 6/50 (12%) | 0/50 (0%) 0/0 (0%) 0/50 (0%) |
|ADJUSTED (b) | 28.6% 7.3% 11.2% 32.5% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 4/24 (17%) 0/20 (0%) 2/24 (8%) 3/14 (21%) | 0/29 (0%) 0/0 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 594 604 701 514 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.416 P=0.069N P=0.077N P=0.459 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.337 P=0.043N* P=0.094N P=0.408 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.396 P=0.037N* P=0.078N P=0.466 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.356N | (e) |
|FISHER EXACT | P=0.025N* P=0.060N P=0.274N | (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 1/7 (14%) 1/50 (2%) |
|ADJUSTED (b) | 3.8% 19.5% 7.6% 12.0% | 0.0% 2.4% 2.3% |
|TERMINAL (d) | 0/24 (0%) 2/20 (10%) 1/24 (4%) 1/14 (7%) | 0/29 (0%) 0/2 (0%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | 718 649 705 696 | --- 673 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.395 P=0.059 P=0.500 P=0.305 | P=0.435 P=0.536 P=0.583 |
|INCIDENTAL TUMOR | P=0.298 P=0.033 * P=0.438 P=0.216 | P=0.315 P=0.331 P=0.583 |
|LOGISTIC REGRESSION | P=0.361 P=0.075 P=0.478 P=0.279 | P=0.372 P=0.119 P=0.583 |
|COCHRAN-ARMITAGE | P=0.544N | P=0.355 |
|FISHER EXACT | P=0.102 P=0.500 P=0.500 | P=0.123 P=0.500 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 1/7 (14%) 1/50 (2%) |
|ADJUSTED (b) | 7.9% 19.5% 7.6% 12.0% | 0.0% 2.4% 2.3% |
|TERMINAL (d) | 1/24 (4%) 2/20 (10%) 1/24 (4%) 1/14 (7%) | 0/29 (0%) 0/2 (0%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | 718 649 705 696 | --- 673 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.534 P=0.136 P=0.692N P=0.477 | P=0.435 P=0.536 P=0.583 |
|INCIDENTAL TUMOR | P=0.442 P=0.091 P=0.646 P=0.395 | P=0.315 P=0.331 P=0.583 |
|LOGISTIC REGRESSION | P=0.499 P=0.157 P=0.679 P=0.448 | P=0.372 P=0.119 P=0.583 |
|COCHRAN-ARMITAGE | P=0.396N | P=0.355 |
|FISHER EXACT | P=0.218 P=0.691N P=0.691N | P=0.123 P=0.500 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 8.9% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/20 (0%) 0/24 (0%) 0/14 (0%) | 1/29 (3%) 0/35 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 640 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.021N* P=0.092N P=0.072N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.065N P=0.145N P=0.220N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.035N* P=0.116N P=0.117N |
|COCHRAN-ARMITAGE | (e) | P=0.037N* |
|FISHER EXACT | (e) (e) (e) | P=0.121N P=0.121N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 4.2% 0.0% 0.0% 0.0% | 8.9% 0.0% 2.3% |
|TERMINAL (d) | 1/24 (4%) 0/20 (0%) 0/24 (0%) 0/14 (0%) | 1/29 (3%) 0/35 (0%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- --- | 640 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.348N P=0.536N P=0.500N P=0.607N | P=0.109N P=0.092N P=0.192N |
|INCIDENTAL TUMOR | P=0.348N P=0.536N P=0.500N P=0.607N | P=0.233N P=0.145N P=0.411N |
|LOGISTIC REGRESSION | P=0.348N P=0.536N P=0.500N P=0.607N | P=0.163N P=0.116N P=0.287N |
|COCHRAN-ARMITAGE | P=0.301N | P=0.174N |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | P=0.121N P=0.309N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 9/50 (18%) 2/50 (4%) 1/50 (2%) | 16/50 (32%) 10/50 (20%) 7/50 (14%) |
|ADJUSTED (b) | 19.5% 40.5% 6.7% 7.1% | 47.5% 26.1% 15.9% |
|TERMINAL (d) | 2/24 (8%) 7/20 (35%) 0/24 (0%) 1/14 (7%) | 12/29 (41%) 7/35 (20%) 7/44 (16%) |
|FIRST INCIDENCE (DAYS) | 683 689 703 729 (T) | 522 687 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.055N P=0.157 P=0.153N P=0.213N | P=0.001N** P=0.052N P=0.002N** |
|INCIDENTAL TUMOR | P=0.077N P=0.101 P=0.200N P=0.287N | P=0.006N** P=0.070N P=0.007N** |
|LOGISTIC REGRESSION | P=0.057N P=0.127 P=0.160N P=0.224N | P=0.005N** P=0.066N P=0.008N** |
|COCHRAN-ARMITAGE | P=0.012N* | P=0.020N* |
|FISHER EXACT | P=0.288 P=0.134N P=0.056N | P=0.127N P=0.028N* |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 9/50 (18%) 2/50 (4%) 1/50 (2%) | 19/50 (38%) 10/50 (20%) 7/50 (14%) |
|ADJUSTED (b) | 19.5% 40.5% 6.7% 7.1% | 53.4% 26.1% 15.9% |
|TERMINAL (d) | 2/24 (8%) 7/20 (35%) 0/24 (0%) 1/14 (7%) | 13/29 (45%) 7/35 (20%) 7/44 (16%) |
|FIRST INCIDENCE (DAYS) | 683 689 703 729 (T) | 522 687 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.055N P=0.157 P=0.153N P=0.213N | P<0.001N** P=0.013N* P<0.001N** |
|INCIDENTAL TUMOR | P=0.077N P=0.101 P=0.200N P=0.287N | P=0.001N** P=0.020N* P=0.002N** |
|LOGISTIC REGRESSION | P=0.057N P=0.127 P=0.160N P=0.224N | P<0.001N** P=0.017N* P=0.001N** |
|COCHRAN-ARMITAGE | P=0.012N* | P=0.004N** |
|FISHER EXACT | P=0.288 P=0.134N P=0.056N | P=0.038N* P=0.006N** |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 9/50 (18%) 2/50 (4%) 1/50 (2%) | 19/50 (38%) 10/50 (20%) 7/50 (14%) |
|ADJUSTED (b) | 23.2% 40.5% 6.7% 7.1% | 53.4% 26.1% 15.9% |
|TERMINAL (d) | 3/24 (13%) 7/20 (35%) 0/24 (0%) 1/14 (7%) | 13/29 (45%) 7/35 (20%) 7/44 (16%) |
|FIRST INCIDENCE (DAYS) | 683 689 703 729 (T) | 522 687 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.033N* P=0.230 P=0.096N P=0.152N | P<0.001N** P=0.013N* P<0.001N** |
|INCIDENTAL TUMOR | P=0.047N* P=0.162 P=0.125N P=0.205N | P=0.001N** P=0.020N* P=0.002N** |
|LOGISTIC REGRESSION | P=0.034N* P=0.192 P=0.099N P=0.161N | P<0.001N** P=0.017N* P=0.001N** |
|COCHRAN-ARMITAGE | P=0.006N** | P=0.004N** |
|FISHER EXACT | P=0.393 P=0.080N P=0.030N* | P=0.038N* P=0.006N** |
|=================================================================================================================================|
| |
|Nose |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/49 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.6% 6.2% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/20 (0%) 0/24 (0%) 0/14 (0%) | 0/28 (0%) 0/35 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 683 604 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.277N P=0.399 P=0.511N P=0.628N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.328N P=0.463 P=0.554N P=0.707N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.225N P=0.518 P=0.510N P=0.616N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.186N | (e) |
|FISHER EXACT | P=0.500 P=0.500N P=0.500N | (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.2% 4.3% 0.0% 14.3% | 3.4% 0.0% 0.0% |
|TERMINAL (d) | 1/24 (4%) 0/20 (0%) 0/24 (0%) 2/14 (14%) | 1/29 (3%) 0/35 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 709 --- 729 (T) | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.236 P=0.726 P=0.500N P=0.314 | P=0.216N P=0.462N P=0.417N |
|INCIDENTAL TUMOR | P=0.212 P=0.680 P=0.500N P=0.314 | P=0.216N P=0.462N P=0.417N |
|LOGISTIC REGRESSION | P=0.219 P=0.707 P=0.500N P=0.314 | P=0.216N P=0.462N P=0.417N |
|COCHRAN-ARMITAGE | P=0.368 | P=0.270N |
|FISHER EXACT | P=0.753N P=0.500N P=0.500 | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 5.3% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/20 (0%) 0/24 (0%) 0/14 (0%) | 0/29 (0%) 0/35 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 507 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.473 (e) P=0.222 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.455 (e) P=0.279 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.591 (e) P=0.265 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.587 | (e) |
|FISHER EXACT | (e) P=0.247 (e) | (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/50 (4%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.2% 4.3% 5.3% 14.3% | 3.4% 0.0% 0.0% |
|TERMINAL (d) | 1/24 (4%) 0/20 (0%) 0/24 (0%) 2/14 (14%) | 1/29 (3%) 0/35 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 709 507 729 (T) | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.177 P=0.726 P=0.482 P=0.314 | P=0.216N P=0.462N P=0.417N |
|INCIDENTAL TUMOR | P=0.148 P=0.680 P=0.547 P=0.314 | P=0.216N P=0.462N P=0.417N |
|LOGISTIC REGRESSION | P=0.168 P=0.707 P=0.515 P=0.314 | P=0.216N P=0.462N P=0.417N |
|COCHRAN-ARMITAGE | P=0.335 | P=0.270N |
|FISHER EXACT | P=0.753N P=0.500 P=0.500 | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 2/5 (40%) 0/50 (0%) |
|ADJUSTED (b) | | 0.0% 40.0% 0.0% |
|TERMINAL (d) | | 0/29 (0%) 2/5 (40%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.543N P=0.007 ** (e) |
|INCIDENTAL TUMOR | | P=0.543N P=0.007 ** (e) |
|LOGISTIC REGRESSION | | P=0.543N P=0.007 ** (e) |
|COCHRAN-ARMITAGE | | P=0.638 |
|FISHER EXACT | | P=0.007 ** (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/49 (24%) 1/49 (2%) 1/49 (2%) 0/50 (0%) | 2/50 (4%) 0/0 (0%) 0/50 (0%) |
|ADJUSTED (b) | 45.9% 4.5% 4.2% 0.0% | 6.9% 0.0% 0.0% |
|TERMINAL (d) | 10/24 (42%) 0/20 (0%) 1/24 (4%) 0/14 (0%) | 2/29 (7%) 0/0 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 705 724 729 (T) --- | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P=0.004N** P=0.001N** P=0.005N** | P=0.083N (e) P=0.152N |
|INCIDENTAL TUMOR | P<0.001N** P=0.005N** P=0.001N** P=0.005N** | P=0.083N (e) P=0.152N |
|LOGISTIC REGRESSION | P<0.001N** P=0.003N** P<0.001N** P=0.004N** | P=0.083N (e) P=0.152N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.143N |
|FISHER EXACT | P<0.001N** P<0.001N** P<0.001N** | P=1.000N P=0.247N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/49 (33%) 22/50 (44%) 14/48 (29%) 10/50 (20%) | 18/49 (37%) 21/50 (42%) 20/50 (40%) |
|ADJUSTED (b) | 48.8% 60.8% 46.6% 48.8% | 53.5% 50.9% 43.3% |
|TERMINAL (d) | 9/24 (38%) 8/20 (40%) 9/24 (38%) 4/14 (29%) | 13/28 (46%) 15/35 (43%) 18/44 (41%) |
|FIRST INCIDENCE (DAYS) | 594 435 633 635 | 589 589 570 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.453N P=0.063 P=0.445N P=0.461 | P=0.135N P=0.496N P=0.166N |
|INCIDENTAL TUMOR | P=0.496 P=0.196 P=0.556N P=0.393 | P=0.468N P=0.564 P=0.475N |
|LOGISTIC REGRESSION | P=0.448N P=0.169 P=0.521N P=0.435 | P=0.410N P=0.559 P=0.468N |
|COCHRAN-ARMITAGE | P=0.032N* | P=0.410 |
|FISHER EXACT | P=0.170 P=0.440N P=0.115N | P=0.371 P=0.449 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 1/50 (2%) 1/48 (2%) 0/50 (0%) | 2/49 (4%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | 12.3% 5.0% 2.7% 0.0% | 5.4% 5.7% 6.8% |
|TERMINAL (d) | 1/24 (4%) 1/20 (5%) 0/24 (0%) 0/14 (0%) | 0/28 (0%) 2/35 (6%) 3/44 (7%) |
|FIRST INCIDENCE (DAYS) | 617 729 (T) 654 --- | 640 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.070N P=0.262N P=0.199N P=0.180N | P=0.580 P=0.622N P=0.663 |
|INCIDENTAL TUMOR | P=0.083N P=0.211N P=0.246N P=0.189N | P=0.420 P=0.678 P=0.436 |
|LOGISTIC REGRESSION | P=0.065N P=0.211N P=0.195N P=0.151N | P=0.466 P=0.676N P=0.534 |
|COCHRAN-ARMITAGE | P=0.033N* | P=0.417 |
|FISHER EXACT | P=0.175N P=0.187N P=0.056N | P=0.684N P=0.510 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/49 (41%) 23/50 (46%) 15/48 (31%) 10/50 (20%) | 20/49 (41%) 23/50 (46%) 23/50 (46%) |
|ADJUSTED (b) | 56.3% 64.0% 48.1% 48.8% | 56.0% 55.9% 49.9% |
|TERMINAL (d) | 10/24 (42%) 9/20 (45%) 9/24 (38%) 4/14 (29%) | 13/28 (46%) 17/35 (49%) 21/44 (48%) |
|FIRST INCIDENCE (DAYS) | 594 435 633 635 | 589 589 570 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.244N P=0.147 P=0.249N P=0.475N | P=0.146N P=0.468N P=0.181N |
|INCIDENTAL TUMOR | P=0.346N P=0.392 P=0.344N P=0.543N | P=0.539 P=0.554 P=0.582 |
|LOGISTIC REGRESSION | P=0.210N P=0.357 P=0.291N P=0.602 | P=0.471N P=0.564 P=0.543N |
|COCHRAN-ARMITAGE | P=0.005N** | P=0.338 |
|FISHER EXACT | P=0.376 P=0.221N P=0.021N* | P=0.376 P=0.376 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 0/48 (0%) 0/50 (0%) | 2/49 (4%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 7.1% 5.2% 2.3% |
|TERMINAL (d) | 0/24 (0%) 0/20 (0%) 0/24 (0%) 0/14 (0%) | 2/28 (7%) 1/35 (3%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 729 (T) 673 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.253N P=0.615N P=0.344N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.306N P=0.609N P=0.344N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.304N P=0.638N P=0.344N |
|COCHRAN-ARMITAGE | (e) | P=0.385N |
|FISHER EXACT | (e) (e) (e) | P=0.684N P=0.492N |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.3% 0.0% 0.0% 11.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/20 (0%) 0/24 (0%) 1/14 (7%) | 0/29 (0%) 0/35 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 703 --- --- 548 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.332 P=0.313N P=0.245N P=0.434 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.285 P=0.360N P=0.297N P=0.409 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.364 P=0.274N P=0.255N P=0.497 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.503 | (e) |
|FISHER EXACT | P=0.247N P=0.247N P=0.691N | (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 8.0% 0.0% | 0.0% 0.0% 2.3% |
|TERMINAL (d) | 0/24 (0%) 0/20 (0%) 1/24 (4%) 0/14 (0%) | 0/29 (0%) 0/35 (0%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | --- --- 719 --- | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.492 (e) P=0.240 (e) | P=0.332 (e) P=0.583 |
|INCIDENTAL TUMOR | P=0.453 (e) P=0.210 (e) | P=0.332 (e) P=0.583 |
|LOGISTIC REGRESSION | P=0.484 (e) P=0.230 (e) | P=0.332 (e) P=0.583 |
|COCHRAN-ARMITAGE | P=0.587 | P=0.273 |
|FISHER EXACT | (e) P=0.247 (e) | (e) P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 3/50 (6%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 4.2% 0.0% 12.0% 0.0% | 3.4% 0.0% 2.3% |
|TERMINAL (d) | 1/24 (4%) 0/20 (0%) 2/24 (8%) 0/14 (0%) | 1/29 (3%) 0/35 (0%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 719 --- | 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.642 P=0.536N P=0.306 P=0.607N | P=0.577N P=0.462N P=0.666N |
|INCIDENTAL TUMOR | P=0.617 P=0.536N P=0.282 P=0.607N | P=0.577N P=0.462N P=0.666N |
|LOGISTIC REGRESSION | P=0.633 P=0.536N P=0.297 P=0.607N | P=0.577N P=0.462N P=0.666N |
|COCHRAN-ARMITAGE | P=0.503N | P=0.668N |
|FISHER EXACT | P=0.500N P=0.309 P=0.500N | P=0.500N P=0.753N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.3% 2.8% 0.0% 11.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/20 (0%) 0/24 (0%) 1/14 (7%) | 0/29 (0%) 0/35 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 703 613 --- 548 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.405 P=0.596N P=0.245N P=0.434 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.349 P=0.537N P=0.297N P=0.409 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.466 P=0.506N P=0.255N P=0.497 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.593 | (e) |
|FISHER EXACT | P=0.500N P=0.247N P=0.691N | (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 3/50 (6%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 14.1% 7.6% 12.0% 11.0% | 3.4% 0.0% 2.3% |
|TERMINAL (d) | 2/24 (8%) 1/20 (5%) 2/24 (8%) 1/14 (7%) | 1/29 (3%) 0/35 (0%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | 703 613 719 548 | 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.561N P=0.448N P=0.505N P=0.643N | P=0.577N P=0.462N P=0.666N |
|INCIDENTAL TUMOR | P=0.567 P=0.403N P=0.562N P=0.663N | P=0.577N P=0.462N P=0.666N |
|LOGISTIC REGRESSION | P=0.584N P=0.412N P=0.527N P=0.630N | P=0.577N P=0.462N P=0.666N |
|COCHRAN-ARMITAGE | P=0.317N | P=0.668N |
|FISHER EXACT | P=0.339N P=0.500N P=0.339N | P=0.500N P=0.753N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 1/50 (2%) 0/50 (0%) 1/50 (2%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 14.8% 4.0% 0.0% 5.6% | 2.3% 2.9% 0.0% |
|TERMINAL (d) | 3/24 (13%) 0/20 (0%) 0/24 (0%) 0/14 (0%) | 0/29 (0%) 1/35 (3%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 683 687 --- 697 | 579 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.179N P=0.265N P=0.065N P=0.389N | P=0.283N P=0.732N P=0.483N |
|INCIDENTAL TUMOR | P=0.219N P=0.287N P=0.072N P=0.450N | P=0.440N P=0.684 P=0.773N |
|LOGISTIC REGRESSION | P=0.194N P=0.248N P=0.069N P=0.416N | P=0.383N P=0.749 P=0.650N |
|COCHRAN-ARMITAGE | P=0.101N | P=0.334N |
|FISHER EXACT | P=0.181N P=0.059N P=0.181N | P=0.753N P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 3/50 (6%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 7.1% 2.2% 9.6% 0.0% | 0.0% 2.0% 0.0% |
|TERMINAL (d) | 1/24 (4%) 0/20 (0%) 1/24 (4%) 0/14 (0%) | 0/29 (0%) 0/35 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 702 529 684 --- | --- 330 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.396N P=0.567N P=0.489 P=0.386N | P=0.732 P=0.504 (e) |
|INCIDENTAL TUMOR | P=0.442N P=0.449N P=0.427 P=0.421N | P=0.500 P=0.500 (e) |
|LOGISTIC REGRESSION | P=0.381N P=0.484N P=0.462 P=0.388N | P=0.386 P=0.322 (e) |
|COCHRAN-ARMITAGE | P=0.243N | P=0.730 |
|FISHER EXACT | P=0.500N P=0.500 P=0.247N | P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 2/50 (4%) 3/50 (6%) 1/50 (2%) | 1/50 (2%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 21.3% 6.1% 9.6% 5.6% | 2.3% 4.8% 0.0% |
|TERMINAL (d) | 4/24 (17%) 0/20 (0%) 1/24 (4%) 0/14 (0%) | 0/29 (0%) 1/35 (3%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 683 529 684 697 | 579 330 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.146N P=0.225N P=0.257N P=0.211N | P=0.320N P=0.532 P=0.483N |
|INCIDENTAL TUMOR | P=0.185N P=0.180N P=0.303N P=0.260N | P=0.610N P=0.414 P=0.773N |
|LOGISTIC REGRESSION | P=0.152N P=0.163N P=0.280N P=0.223N | P=0.617N P=0.389 P=0.650N |
|COCHRAN-ARMITAGE | P=0.053N | P=0.365N |
|FISHER EXACT | P=0.134N P=0.243N P=0.056N | P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 46/50 (92%) 45/50 (90%) 42/50 (84%) 24/50 (48%) | |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 95.9% | |
|TERMINAL (d) | 24/24 (100%) 20/20 (100%) 24/24 (100%) 13/14 (93%) | |
|FIRST INCIDENCE (DAYS) | 507 520 486 488 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.272N P=0.141 P=0.390N P=0.452N | |
|INCIDENTAL TUMOR | P=0.509N P=0.623 P=0.512N P=0.520N | |
|LOGISTIC REGRESSION | P=0.479N P=0.492 P=0.631N P=0.555N | |
|COCHRAN-ARMITAGE | P<0.001N** | |
|FISHER EXACT | P=0.500N P=0.178N P<0.001N** | |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 6/50 (12%) 7/49 (14%) 5/50 (10%) | 7/50 (14%) 0/2 (0%) 9/50 (18%) |
|ADJUSTED (b) | 40.9% 21.7% 25.9% 24.5% | 19.7% 0.0% 19.8% |
|TERMINAL (d) | 8/24 (33%) 2/20 (10%) 5/24 (21%) 1/14 (7%) | 3/29 (10%) 0/2 (0%) 8/44 (18%) |
|FIRST INCIDENCE (DAYS) | 649 520 687 548 | 444 --- 517 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.300N P=0.226N P=0.164N P=0.391N | P=0.493N P=0.046N* P=0.524N |
|INCIDENTAL TUMOR | P=0.390N P=0.221N P=0.201N P=0.458N | P=0.292 P=0.772N P=0.350 |
|LOGISTIC REGRESSION | P=0.338N P=0.159N P=0.192N P=0.399N | P=0.290 P=0.700N P=0.346 |
|COCHRAN-ARMITAGE | P=0.062N | P=0.341 |
|FISHER EXACT | P=0.096N P=0.166N P=0.054N | P=0.747N P=0.393 |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/50 (26%) 7/50 (14%) 7/49 (14%) 5/50 (10%) | 8/50 (16%) 0/2 (0%) 9/50 (18%) |
|ADJUSTED (b) | 42.7% 24.4% 25.9% 24.5% | 22.8% 0.0% 19.8% |
|TERMINAL (d) | 8/24 (33%) 2/20 (10%) 5/24 (21%) 1/14 (7%) | 4/29 (14%) 0/2 (0%) 8/44 (18%) |
|FIRST INCIDENCE (DAYS) | 649 520 687 548 | 444 --- 517 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.222N P=0.263N P=0.117N P=0.331N | P=0.362N P=0.044N* P=0.399N |
|INCIDENTAL TUMOR | P=0.304N P=0.271N P=0.148N P=0.400N | P=0.423 P=0.698N P=0.485 |
|LOGISTIC REGRESSION | P=0.243N P=0.170N P=0.136N P=0.327N | P=0.412 P=0.650N P=0.471 |
|COCHRAN-ARMITAGE | P=0.034N* | P=0.448 |
|FISHER EXACT | P=0.105N P=0.115N P=0.033N* | P=0.713N P=0.500 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 13/50 (26%) 13/50 (26%) 7/50 (14%) |
|ADJUSTED (b) | | 39.7% 32.9% 15.4% |
|TERMINAL (d) | | 10/29 (34%) 9/35 (26%) 6/44 (14%) |
|FIRST INCIDENCE (DAYS) | | 526 667 517 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.011N* P=0.381N P=0.015N* |
|INCIDENTAL TUMOR | | P=0.046N* P=0.413N P=0.050N* |
|LOGISTIC REGRESSION | | P=0.044N* P=0.453N P=0.063N |
|COCHRAN-ARMITAGE | | P=0.093N |
|FISHER EXACT | | P=0.590N P=0.105N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | | 5.0% 2.2% 0.0% |
|TERMINAL (d) | | 0/29 (0%) 0/35 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | | 590 611 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.113N P=0.448N P=0.198N |
|INCIDENTAL TUMOR | | P=0.464N P=0.678 P=0.574N |
|LOGISTIC REGRESSION | | P=0.221N P=0.565N P=0.343N |
|COCHRAN-ARMITAGE | | P=0.143N |
|FISHER EXACT | | P=0.500N P=0.247N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 15/50 (30%) 14/50 (28%) 7/50 (14%) |
|ADJUSTED (b) | | 42.7% 34.3% 15.4% |
|TERMINAL (d) | | 10/29 (34%) 9/35 (26%) 6/44 (14%) |
|FIRST INCIDENCE (DAYS) | | 526 611 517 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.004N** P=0.296N P=0.005N** |
|INCIDENTAL TUMOR | | P=0.039N* P=0.449N P=0.037N* |
|LOGISTIC REGRESSION | | P=0.025N* P=0.413N P=0.035N* |
|COCHRAN-ARMITAGE | | P=0.040N* |
|FISHER EXACT | | P=0.500N P=0.045N* |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 23/50 (46%) 22/50 (44%) 15/50 (30%) 8/50 (16%) | 11/50 (22%) 14/50 (28%) 9/50 (18%) |
|ADJUSTED (b) | 72.0% 63.3% 43.0% 40.0% | 32.8% 32.8% 20.5% |
|TERMINAL (d) | 16/24 (67%) 9/20 (45%) 7/24 (29%) 3/14 (21%) | 8/29 (28%) 8/35 (23%) 9/44 (20%) |
|FIRST INCIDENCE (DAYS) | 611 488 486 548 | 526 345 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.051N P=0.341 P=0.108N P=0.122N | P=0.098N P=0.513 P=0.115N |
|INCIDENTAL TUMOR | P=0.060N P=0.393N P=0.097N P=0.136N | P=0.337N P=0.325 P=0.226N |
|LOGISTIC REGRESSION | P=0.031N* P=0.560 P=0.113N P=0.130N | P=0.347N P=0.327 P=0.277N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.363N |
|FISHER EXACT | P=0.500N P=0.074N P=0.001N** | P=0.322 P=0.402N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 4/50 (8%) 1/50 (2%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.4% 11.2% 4.0% 7.1% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/24 (0%) 0/20 (0%) 0/24 (0%) 1/14 (7%) | 0/29 (0%) 0/35 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 624 520 719 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.296N P=0.385 P=0.320N P=0.556N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.354N P=0.646 P=0.418N P=0.591N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.214N P=0.547 P=0.326N P=0.533N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.136N | (e) |
|FISHER EXACT | P=0.500 P=0.309N P=0.309N | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 49/50 (98%) 45/50 (90%) 26/50 (52%) | 40/50 (80%) 35/50 (70%) 35/50 (70%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 90.8% 79.5% 71.4% |
|TERMINAL (d) | 24/24 (100%) 20/20 (100%) 24/24 (100%) 14/14 (100%)| 25/29 (86%) 26/35 (74%) 30/44 (68%) |
|FIRST INCIDENCE (DAYS) | 507 435 486 488 | 444 589 517 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.299N P=0.115 P=0.407N P=0.491N | P<0.001N** P=0.036N* P=0.001N** |
|INCIDENTAL TUMOR | P=0.654 P=0.748N (e) (e) | P=0.067N P=0.079N P=0.113N |
|LOGISTIC REGRESSION | P=0.654 P=0.748N (e) (e) | P=0.037N* P=0.064N P=0.077N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.154N |
|FISHER EXACT | P=0.753N P=0.102N P<0.001N** | P=0.178N P=0.178N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 10.MG/KG 20.MG/KG 40.MG/KG | VEHICLE 20.MG/KG 40.MG/KG |
| | 15 SSAC 15 SSAC 15 SSAC 15 SSAC | 15 SSAC 15 SSAC 15 SSAC |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 39/50 (78%) 33/50 (66%) 28/50 (56%) 11/50 (22%) | 22/50 (44%) 20/50 (40%) 18/50 (36%) |
|ADJUSTED (b) | 88.2% 76.8% 68.4% 54.2% | 52.2% 45.4% 37.4% |
|TERMINAL (d) | 19/24 (79%) 11/20 (55%) 12/24 (50%) 5/14 (36%) | 10/29 (34%) 12/35 (34%) 14/44 (32%) |
|FIRST INCIDENCE (DAYS) | 507 437 486 548 | 353 330 517 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007N** P=0.482 P=0.097N P=0.014N* | P=0.034N* P=0.231N P=0.042N* |
|INCIDENTAL TUMOR | P=0.001N** P=0.088N P=0.039N* P=0.003N** | P=0.526N P=0.527N P=0.576N |
|LOGISTIC REGRESSION | P<0.001N** P=0.151N P=0.037N* P=0.001N** | P=0.423N P=0.514N P=0.415N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.238N |
|FISHER EXACT | P=0.133N P=0.016N* P<0.001N** | P=0.420N P=0.270N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 50/50 (100%) 45/50 (90%) 26/50 (52%) | 45/50 (90%) 41/50 (82%) 41/50 (82%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 93.7% 83.7% 83.6% |
|TERMINAL (d) | 24/24 (100%) 20/20 (100%) 24/24 (100%) 14/14 (100%)| 26/29 (90%) 27/35 (77%) 36/44 (82%) |
|FIRST INCIDENCE (DAYS) | 507 435 486 488 | 353 330 517 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.288N P=0.093 P=0.407N P=0.491N | P<0.001N** P=0.057N P<0.001N** |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.228N P=0.171N P=0.200N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.133N P=0.160N P=0.113N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.165N |
|FISHER EXACT | P=0.500 P=0.102N P<0.001N** | P=0.194N P=0.194N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05037 TEST: 03 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTACHLOROANISOLE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).