TDMS Study 05037-03 Pathology Tables
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
Facility: Southern Research Institute
Chemical CAS #: 1825-21-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 VEHICLE CONTROL
Include 004 VEHICLE CONTROL
Include 007 40 MG/KG
Include 010 40 MG/KG
Include 013 20 MG/KG
Include 016 20 MG/KG
Include 019 10 MG/KG
Page 1
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 2| 2| 2| 2| 9| 8| 0| 2| 2| 7| 8| 2| 2| 2| 7| 4| 2| 2| 2| 7| 8| 3| 3| 3|
| 0| 9| 9| 9| 9| 6| 3| 5| 9| 9| 9| 7| 9| 9| 9| 7| 4| 9| 9| 9| 9| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Eosinophilic Focus | X |
Granuloma | 2 1 3 1 1 2 1 2 2 1 3 3 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal | 2|
Inflammation, Chronic | 1 3 1 |
Inflammation, Chronic Active | 3 |
Bile Duct, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 3|
Centrilobular, Atrophy | 2 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 |
Kupffer Cell, Pigmentation | 1 |
Lobules, Necrosis | 2 |
Oval Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
Cyst | X |
Fat, Inflammation, Chronic Active | 3 3 |
Fat, Necrosis | 3 4 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 1 1 1 |
Cytoplasmic Alteration | 4 |
Hyperplasia, Focal | 2 1 2 |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 2| 2| 2| 2| 9| 8| 0| 2| 2| 7| 8| 2| 2| 2| 7| 4| 2| 2| 2| 7| 8| 3| 3| 3|
| 0| 9| 9| 9| 9| 6| 3| 5| 9| 9| 9| 7| 9| 9| 9| 7| 4| 9| 9| 9| 9| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Chronic Active | |
Ulcer | 3 |
Mucosa, Hyperplasia | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Mineralization | 2 1 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 1 2 1 1 2 2 2 3|
Myocardium, Inflammation, Chronic | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X|
Angiectasis | 1 1 2 2 2 1 1 1 1 2 1 1 2 |
Clear Cell Focus | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 3 1 3 3 1 1 2 2|
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X X X X X X X |
Pars Distalis, Hyperplasia | 1 3 2 2 |
Pars Distalis, Pigmentation | 2 2 2 2 3|
Pars Intermedia, Cyst | X |
Pars Nervosa, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia | 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 2| 2| 2| 2| 9| 8| 0| 2| 2| 7| 8| 2| 2| 2| 7| 4| 2| 2| 2| 7| 8| 3| 3| 3|
| 0| 9| 9| 9| 9| 6| 3| 5| 9| 9| 9| 7| 9| 9| 9| 7| 4| 9| 9| 9| 9| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 3 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 3 |
Cyst | |
Hydrometra | 2 2 |
Hyperplasia, Cystic | 1 1 1 2 1 2 2 1|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
Hyperplasia, Reticulum Cell | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Hemorrhage | 3 2 3 2 |
Mediastinal, Pigmentation | 3 3 3 4 3 |
Pancreatic, Hyperplasia, Plasma Cell | |
Pancreatic, Lymphatic, Dilatation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 2 3 2 2 3|
Infiltration Cellular, Mast Cell | |
Lymphatic, Dilatation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 |
Hyperplasia, Re Cell | 2 |
Necrosis | 2 |
Pigmentation, Hemosiderin | 3 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Cystic | 2 3 2 1 2 2 2 1 3 1 4 2 1 3 2 2 2 4 3|
Hyperplasia, Lobular | 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 4 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 2| 2| 2| 2| 9| 8| 0| 2| 2| 7| 8| 2| 2| 2| 7| 4| 2| 2| 2| 7| 8| 3| 3| 3|
| 0| 9| 9| 9| 9| 6| 3| 5| 9| 9| 9| 7| 9| 9| 9| 7| 4| 9| 9| 9| 9| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Osteopetrosis | 2 2|
Femur, Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X|
Degeneration, Focal | |
Hemorrhage | |
Hydrocephalus | 2 |
Pigmentation | |
Meninges, Fibrosis | 4 |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Edema | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic | 1 1 1 1 1 |
Pigmentation, Cholesterol | 1 |
Alveolar Epithelium, Hyperplasia | |
Smooth Muscle, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +|
Exudate | X |
Foreign Body | |
Fungus | |
Inflammation, Chronic | |
Glands, Hyperplasia | |
Glands, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 9| 2| 2| 2| 2| 9| 8| 0| 2| 2| 7| 8| 2| 2| 2| 7| 4| 2| 2| 2| 7| 8| 3| 3| 3|
| 0| 9| 9| 9| 9| 6| 3| 5| 9| 9| 9| 7| 9| 9| 9| 7| 4| 9| 9| 9| 9| 4| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
VEHICLE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 3 1 1 2 |
Inflammation, Suppurative | 2 |
Mineralization | 1 1 2 1 2 1 2 2 2 1 1 2|
Nephropathy | 1 1 1 1 1 1 2 1 1 2 1 1 1 2 1 1 1 2 1 2 1 1|
Renal Tubule, Degeneration | |
Renal Tubule, Dilatation | 3 |
Transitional Epithelium, Hyperplasia | 1 3 |
__________________________________________________________________________|
Urethra | + |
Inflammation, Chronic | 4 |
Necrosis | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 3| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 2| 6| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 5| 2| 0| 3| 3| |
| 2| 9| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 3| 6| 0| 0| 0| 3| 6| 5| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 2 2.0|
Parasite Metazoan | X X X| 7 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 42 |
Clear Cell Focus | X X | 5 |
Eosinophilic Focus | | 1 |
Granuloma | 1 2 1 1 2 3 2 2 3 3 2 3 1 2 1 2 | 29 1.9|
Hematopoietic Cell Proliferation | 3 | 2 2.0|
Hepatodiaphragmatic Nodule | X X X | 3 |
Hyperplasia, Focal | 3 2 1 | 4 2.0|
Inflammation, Chronic | 1 2 1 1 1 2 2 2 | 11 1.5|
Inflammation, Chronic Active | | 1 3.0|
Bile Duct, Hyperplasia | 1 1 2 1 1 2 1 1 2 1 1 1 1 1 1| 31 1.2|
Centrilobular, Atrophy | | 1 2.0|
Centrilobular, Necrosis | 2 | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 4 | 4 2.5|
Kupffer Cell, Pigmentation | 3 1 | 3 1.7|
Lobules, Necrosis | 2 | 2 2.0|
Oval Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + +| 13 |
Cyst | | 1 |
Fat, Inflammation, Chronic Active | | 2 3.0|
Fat, Necrosis | 3 3 3 3 1| 10 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 2 2 2 | 11 1.8|
Cytoplasmic Alteration | 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 3| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 2| 6| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 5| 2| 0| 3| 3| |
| 2| 9| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 3| 6| 0| 0| 0| 3| 6| 5| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Focal | | 3 1.7|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 1 2 | 3 1.7|
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | 2 | 2 2.5|
Mucosa, Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 2 1.5|
Mineralization | 2| 3 1.7|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1 2 1 1| 20 1.5|
Myocardium, Inflammation, Chronic | | 4 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X | 9 |
Angiectasis | 1 2 2 2 1 1 2 1 1 2 2| 24 1.5|
Clear Cell Focus | X X X X | 4 |
Hematopoietic Cell Proliferation | 2 1 | 2 1.5|
Hyperplasia, Focal | 1 1 3 2 | 12 1.9|
Hypertrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2| 1 2.0|
Hyperplasia | 2 1 2 1 1 2| 10 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 3| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 2| 6| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 5| 2| 0| 3| 3| |
| 2| 9| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 3| 6| 0| 0| 0| 3| 6| 5| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Angiectasis | 2 3 3 | 4 2.5|
Pars Distalis, Cyst | X X X X X X X X X X X X | 20 |
Pars Distalis, Hyperplasia | 1 2 1 1 2 | 9 1.7|
Pars Distalis, Pigmentation | 2 1 2 2| 9 2.0|
Pars Intermedia, Cyst | | 1 |
Pars Nervosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 3 |
C-Cell, Hyperplasia | 1 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 | 4 2.8|
Inflammation, Chronic | 1 2 | 3 2.0|
Inflammation, Suppurative | 3 | 3 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 2 3.0|
Cyst | X | 1 |
Hydrometra | 3 2 3 2 2 | 7 2.3|
Hyperplasia, Cystic | 2 2 1 1 2| 13 1.5|
__________________________________________________________________________|____________|
Vagina | M + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 4 | 1 4.0|
Hyperplasia, Reticulum Cell | 2 1 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Hemorrhage | 3 2 2 | 7 2.4|
Mediastinal, Pigmentation | 3 3 3 2 3 | 10 3.0|
Pancreatic, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Pancreatic, Lymphatic, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 3| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 2| 6| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 5| 2| 0| 3| 3| |
| 2| 9| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 3| 6| 0| 0| 0| 3| 6| 5| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Plasma Cell | 2 2 2 3 2 2 2 2 2| 14 2.2|
Infiltration Cellular, Mast Cell | 3 | 1 3.0|
Lymphatic, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Hemorrhage | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 2 3 2 3 2 2| 15 2.3|
Hyperplasia, Re Cell | | 1 2.0|
Necrosis | | 1 2.0|
Pigmentation, Hemosiderin | 3 2 | 5 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + I + + + + + + + + + +| 47 |
Cyst | X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Hyperplasia, Cystic | 2 2 1 1 3 4 2 3 2 2 1 4 1 1 1 2 2 2 2| 38 2.1|
Hyperplasia, Lobular | 1 | 4 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calvarium, Osteopetrosis | 3 3 3 | 5 2.6|
Femur, Osteopetrosis | 3 2 4 2 3 | 6 2.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X | 6 |
Degeneration, Focal | 2 | 1 2.0|
Hemorrhage | 4 | 1 4.0|
Hydrocephalus | 2 3 2 | 4 2.3|
Pigmentation | 1 | 1 1.0|
Meninges, Fibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 2 3.0|
Edema | 1 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 6| 7| 7| 7| 3| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 2| 6| 3| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 5| 2| 0| 3| 3| |
| 2| 9| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 3| 6| 0| 0| 0| 3| 6| 5| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
VEHICLE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 3 | 24 1.1|
Inflammation, Chronic | 1 1 1 1 1 1 1| 12 1.0|
Pigmentation, Cholesterol | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 2 3 | 3 2.7|
Smooth Muscle, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Exudate | X X | 3 |
Foreign Body | 2 | 1 2.0|
Fungus | X | 1 |
Inflammation, Chronic | 2 2 2 2 2 | 5 2.0|
Glands, Hyperplasia | 3 | 1 3.0|
Glands, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 3 | 1 3.0|
Retina, Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X| 1 |
Hydronephrosis | | 1 3.0|
Inflammation, Chronic | 1 2 | 7 1.6|
Inflammation, Suppurative | | 1 2.0|
Mineralization | 1 2 1 1 2 1 1 2 2| 21 1.5|
Nephropathy | 1 1 1 1 2 1 1 2 1 1 1 1 2 1 1 1 1 1 1| 41 1.2|
Renal Tubule, Degeneration | 4 | 1 4.0|
Renal Tubule, Dilatation | | 1 3.0|
Transitional Epithelium, Hyperplasia | 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Chronic | | 1 4.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
40 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Necrosis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Developmental Malformation | X X X X |
Eosinophilic Focus | |
Granuloma | 2 1 3 1 2 1 1 1 1|
Hematopoietic Cell Proliferation | 3 1 |
Hepatodiaphragmatic Nodule | X X X X|
Hyperplasia, Focal | 3 3 4 3 |
Inflammation, Chronic | 1 1 1 1 |
Mixed Cell Focus | 3 X |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 |
Centrilobular, Necrosis | |
Hepatocyte, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Pigmentation | 1 |
Lobules, Necrosis | 1 |
Oval Cell, Hyperplasia | 2 |
Portal, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Necrosis | |
Fat, Necrosis | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
40 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic Active | |
Ulcer | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 1 2 2 2 2 1 1 2 2 2|
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X |
Angiectasis | 2 1 2 2 2 2 2 3 1 2 2 3 |
Clear Cell Focus | X X |
Cyst | |
Hyperplasia, Focal | 3 2 3 1 1 1 1 |
Hypertrophy, Focal | |
Vacuolization Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 1 1 1 2 1 1 1 1 1 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 4 1 2 2 |
Pars Distalis, Cyst | X X X X X X X X |
Pars Distalis, Hyperplasia | 1 1 3 3 2 2 |
Pars Distalis, Pigmentation | 2 1 1 2 2 2 |
Pars Intermedia, Angiectasis | 3 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 1 1 1 3 2 2 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
40 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia | 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X |
Hemorrhage | 3 |
Hydrometra | 2 |
Hyperplasia, Cystic | 1 1 1 1 1 2 1 3 1 |
Inflammation, Suppurative | 1 |
Myometrium, Hyperplasia | 3 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 4 |
Hyperplasia, Reticulum Cell | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hemorrhage | 2 |
Bronchial, Pigmentation | 3 |
Mediastinal, Hemorrhage | 4 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Mediastinal, Pigmentation | 3 3 3 3 3 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Renal, Hemorrhage | 3 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 2 2 3 3 2 3 2 2 2 3 |
Pigmentation | 3 |
Lymphatic, Dilatation | 3 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
40 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 3 3|
Lymphatic, Dilatation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 4 2 3 |
Pigmentation, Hemosiderin | 3 3 3 3 |
Lymphoid Follicle, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 1 1 1 1 2 2 3 1 1 2 2 2 2 |
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | |
Hydrocephalus | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1 1|
Inflammation, Suppurative | 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Exudate | X X |
Foreign Body | 2 |
Fungus | X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
40 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 2 2 2 2 3 |
Mucosa, Hyperplasia | 2 |
Olfactory Epithelium, Pigmentation | 1 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 1 3 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 2 2 |
Cornea, Inflammation, Chronic Active | |
Cornea, Mineralization | 1 |
Retina, Atrophy | 3 3 3 |
Sclera, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | 3 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 1 1 2 1 2 |
Inflammation, Suppurative | |
Mineralization | 2 1 1 1 1 |
Nephropathy | 1 1 2 2 1 1 1 1 1 1 1 2 1 2 3 2 1 1 1 1|
Renal Tubule, Atrophy | |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Pigmentation | 2 2 2 3 2 2 3 1 2 3 2 2 3 1 1 1 2 2 3 3 3 3|
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Subacute | 1 2 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 7| 8| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
40 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | | 1 2.0|
Parasite Metazoan | X X X X X | 9 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X | 45 |
Clear Cell Focus | | 2 |
Developmental Malformation | X | 5 |
Eosinophilic Focus | X X | 2 |
Granuloma | 2 1 1 1 1 2 2 3 1 1 2 2 2 1 2 | 24 1.5|
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Hepatodiaphragmatic Nodule | X | 5 |
Hyperplasia, Focal | 2 | 5 3.0|
Inflammation, Chronic | 1 2 1 1 1 1 1 2 | 12 1.2|
Mixed Cell Focus | X X | 4 3.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 2 1 1| 17 1.1|
Centrilobular, Necrosis | 1 | 1 1.0|
Hepatocyte, Pigmentation | 1 1 1 1 1 1 1 1 2 1 1| 24 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 3| 1 3.0|
Kupffer Cell, Pigmentation | | 1 1.0|
Lobules, Necrosis | | 1 1.0|
Oval Cell, Hyperplasia | | 1 2.0|
Portal, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + +| 7 |
Necrosis | 4| 1 4.0|
Fat, Necrosis | 3 3 3 2 | 6 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 7| 8| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
40 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy | 1 2 2 1 1 3| 10 1.4|
Inflammation, Chronic | 1 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 3 1.7|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3| 1 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | 2| 1 2.0|
Mucosa, Hyperplasia | 1 2| 3 1.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 1 1 1 1 1 1 2 1 3 1 2 1 2 2| 31 1.6|
Myocardium, Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X | 13 |
Angiectasis | 3 2 2 2 2 2 3 2 1 2 2 2 2 2 1 | 27 2.0|
Clear Cell Focus | X X | 4 |
Cyst | X | 1 |
Hyperplasia, Focal | 1 2 2 1 2 | 12 1.7|
Hypertrophy, Focal | 1 2 1 1 | 4 1.3|
Vacuolization Cytoplasmic, Diffuse | 3| 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Hyperplasia | 1 2 2 1 2 1 1 2 1 1 2 1 1| 25 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 7| 8| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
40 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Angiectasis | 3 3 2 | 8 2.3|
Pars Distalis, Cyst | X X X X X X X X X X X X| 20 |
Pars Distalis, Hyperplasia | 1 1 | 8 1.8|
Pars Distalis, Pigmentation | 1 2 1 | 9 1.6|
Pars Intermedia, Angiectasis | | 1 3.0|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 2 1 2 2 1 | 13 1.7|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2| 2 2.5|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 2 2 2 2| 5 2.0|
Inflammation, Suppurative | 3 2 3 1 | 4 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3 3 | 2 3.0|
Cyst | X | 2 |
Hemorrhage | | 1 3.0|
Hydrometra | 4 3 3 2 3 | 6 2.8|
Hyperplasia, Cystic | 2 1 1 1 1 1 2 1 2 1 2| 20 1.4|
Inflammation, Suppurative | 1 | 2 1.0|
Myometrium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | + + M| 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 3 | 2 3.5|
Hyperplasia, Reticulum Cell | 3 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchial, Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 7| 8| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
40 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Bronchial, Pigmentation | | 1 3.0|
Mediastinal, Hemorrhage | | 2 3.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| 2 | 2 2.5|
Mediastinal, Pigmentation | 2 3 | 7 2.9|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
Renal, Hemorrhage | | 1 3.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
Hyperplasia, Plasma Cell | 2 3 3 3 2 2 2 2 3 | 20 2.4|
Pigmentation | | 1 3.0|
Lymphatic, Dilatation | 2 | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 3 2.7|
Lymphatic, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 2 2.0|
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 2 4 2 | 6 2.8|
Pigmentation, Hemosiderin | 3 3 3 | 7 3.0|
Lymphoid Follicle, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 4 2 1 2 1 2 1 1 2 2 2 1 1 2 1 2 2 | 33 1.7|
Hyperplasia, Lobular | 1 3 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Osteopetrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 7| 8| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
40 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 4 |
Hemorrhage | 3| 1 3.0|
Hydrocephalus | 1 2 2 | 4 1.8|
Necrosis | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 31 1.0|
Inflammation, Chronic | 1 1 1 1 1 | 18 1.1|
Inflammation, Suppurative | | 1 1.0|
Thrombosis | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 1 |
Exudate | X X X X X| 7 |
Foreign Body | | 1 2.0|
Fungus | | 1 |
Inflammation, Chronic | 2 2 2 3 2| 11 2.2|
Mucosa, Hyperplasia | 2 | 2 2.0|
Olfactory Epithelium, Pigmentation | 2 3 2 2 2 1 2 3 3 3 2 3 2 2 2 2 2 2 1 2 1 1 3 2 2| 50 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + + +| 8 |
Cataract | 2 2 4 2 2| 8 2.4|
Cornea, Inflammation, Chronic Active | 1 | 1 1.0|
Cornea, Mineralization | | 1 1.0|
Retina, Atrophy | 3 3 4 3 3| 8 3.1|
Sclera, Mineralization | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Hydronephrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 7| 8| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
40 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 4 1 1 2 | 10 1.6|
Inflammation, Suppurative | 1 | 1 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 | 15 1.1|
Nephropathy | 1 1 1 1 1 4 1 1 1 1 1 1 2 1 1 1 2 1 1 1 2 2 | 42 1.3|
Renal Tubule, Atrophy | 4 | 1 4.0|
Renal Tubule, Dilatation | | 1 3.0|
Renal Tubule, Pigmentation | 2 3 2 2 2 4 2 2 3 2 2 2 2 2 2 2 2 3 2 2 3 2 2| 45 2.2|
Transitional Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Hemorrhage | | 1 1.0|
Inflammation, Subacute | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 3| 3| 6| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 4| 2| 6| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 7|
| 0| 5| 5| 7| 7| 6| 6| 6| 6| 6| 1| 2| 6| 6| 6| 7| 9| 6| 6| 6| 6| 6| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
20 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | + |
__________________________________________________________________________|
Intestine Large, Rectum | + |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Developmental Malformation | X|
Granuloma | 1 2 2 3 2 1 3 1 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X X X X |
Hyperplasia, Focal | 2 3 2 2 2 |
Inflammation, Chronic | 1 1 1 1 1 |
Mixed Cell Focus | 4 X |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Centrilobular, Atrophy | 2 |
Centrilobular, Necrosis | |
Hepatocyte, Pigmentation | 1 1 1 1 1 1 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
Kupffer Cell, Pigmentation | 2 |
Lobules, Necrosis | 1 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 4 |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
Foreign Body | |
Inflammation, Chronic Active | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X |
Angiectasis | 1 2 1 2 2 2 1 3 1 1 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 3| 3| 6| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 4| 2| 6| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 7|
| 0| 5| 5| 7| 7| 6| 6| 6| 6| 6| 1| 2| 6| 6| 6| 7| 9| 6| 6| 6| 6| 6| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
20 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Clear Cell Focus | X |
Degeneration, Fatty | 3 |
Hyperplasia, Focal | 2 2 2 1 2 2 1|
Hypertrophy, Focal | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 3 1 1 1 1 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 4 3 2 |
Pars Distalis, Cyst | X X X X X X X X X X X X X X |
Pars Distalis, Hyperplasia | 1 2 2 3 |
Pars Distalis, Pigmentation | 1 2 2 1 1 1 2 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | X |
Pars Intermedia, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + |
Ectasia | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Angiectasis | |
Hemorrhage | 3 3 |
Hydrometra | |
Hyperplasia, Cystic | 2 1 1 1 1 3 |
Necrosis | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Inguinal, Hyperplasia, Plasma Cell | |
Lumbar, Hyperplasia, Plasma Cell | |
Lumbar, Lymphatic, Dilatation | |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Mediastinal, Pigmentation | 4 |
Pancreatic, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 3| 3| 6| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 4| 2| 6| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 7|
| 0| 5| 5| 7| 7| 6| 6| 6| 6| 6| 1| 2| 6| 6| 6| 7| 9| 6| 6| 6| 6| 6| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
20 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Lymphatic, Dilatation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + |
Developmental Malformation | |
Hematopoietic Cell Proliferation | 2 3 |
Necrosis | 3 |
Pigmentation, Hemosiderin | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + +|
Hyperplasia, Cystic | 2 1 3 2 3 1|
Hyperplasia, Lobular | 2 |
__________________________________________________________________________|
Skin | + + + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
Calvarium, Osteopetrosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
Compression | X X |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + +|
Congestion | 4|
Infiltration Cellular, Histiocyte | 1 1 2 |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 3 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X|
Foreign Body | 2 2 |
Fungus | X X|
Inflammation, Chronic | 3 3 3 3 |
Mucosa, Hyperplasia | 2 2|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 3| 3| 6| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 4| 2| 6| 8| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 4| 8| 3| 3| 3| 3| 3| 3| 3| 7|
| 0| 5| 5| 7| 7| 6| 6| 6| 6| 6| 1| 2| 6| 6| 6| 7| 9| 6| 6| 6| 6| 6| 6| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
20 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Metaplasia, Squamous | 2 2 |
Olfactory Epithelium, Pigmentation | 1 2 1 1 2 2 2 1 1 2 2 1 1 2 2 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 3 |
Phthisis Bulbi | |
Retina, Atrophy | 4 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 2 2 2 3 3 2 |
Inflammation, Suppurative | 1 |
Mineralization | 1 2 1 1 1 1 1 2 1 2 1|
Nephropathy | 1 1 1 2 2 2 2 2 2 4 1 3 1 2 1 2 3 1 1 1 1 1 1|
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | 3 1 2 2 1 2 2 2 2 2 1 2 3 2 1 1 2 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 8| 6| 6| 6| 6| 6| 6| 6| 6| 1| 4| 6| 6| 6| 2| 5| 6| 6| 6| 6| 6| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
20 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 1 |
__________________________________________________________________________|____________|
Intestine Small | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 2| 4 2.3|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X| 44 |
Clear Cell Focus | X X X | 3 |
Developmental Malformation | | 1 |
Granuloma | 1 1 1 1 1 1 1 1 3 2 1 | 19 1.5|
Hematopoietic Cell Proliferation | 2 2 2| 4 2.0|
Hepatodiaphragmatic Nodule | X X | 7 |
Hyperplasia, Focal | 2 | 6 2.2|
Inflammation, Chronic | 1 1 1 1 3 | 10 1.2|
Mixed Cell Focus | X X | 4 4.0|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1 1 1 | 27 1.0|
Centrilobular, Atrophy | | 1 2.0|
Centrilobular, Necrosis | 1 | 1 1.0|
Hepatocyte, Pigmentation | 3 1 1 2 2 1 1 1 1 1| 18 1.3|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 3 2.0|
Kupffer Cell, Pigmentation | 2 | 2 2.0|
Lobules, Necrosis | 1 | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 2 | 3 2.7|
__________________________________________________________________________|____________|
Stomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
Foreign Body | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 8| 6| 6| 6| 6| 6| 6| 6| 6| 1| 4| 6| 6| 6| 2| 5| 6| 6| 6| 6| 6| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
20 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X X | 13 |
Angiectasis | 1 2 2 1 1 2 2 2 1 1 2 2 2 1 1| 30 1.6|
Clear Cell Focus | X X X | 4 |
Degeneration, Fatty | | 1 3.0|
Hyperplasia, Focal | 2 2 1 1 2 3 | 13 1.8|
Hypertrophy, Focal | 2 1 | 3 1.7|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | 1 2 1 2 3 2 1 1 1 2 1 2 | 18 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 1 | 7 2.6|
Pars Distalis, Cyst | X X X X X X X X X X X X X | 27 |
Pars Distalis, Hyperplasia | 1 1 1 1 | 8 1.5|
Pars Distalis, Pigmentation | 1 2 2 | 10 1.5|
Pars Intermedia, Angiectasis | | 1 2.0|
Pars Intermedia, Cyst | X | 2 |
Pars Intermedia, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + +| 8 |
Ectasia | 2 | 2 2.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + | 5 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3 | 1 3.0|
Angiectasis | 3 | 1 3.0|
Hemorrhage | 4 | 3 3.3|
Hydrometra | 2 3| 2 2.5|
Hyperplasia, Cystic | 1 3 1 1 2 1 2| 13 1.5|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 8| 6| 6| 6| 6| 6| 6| 6| 6| 1| 4| 6| 6| 6| 2| 5| 6| 6| 6| 6| 6| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
20 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + M + + + | 11 |
Inguinal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Lumbar, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Lumbar, Lymphatic, Dilatation | 4 | 1 4.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
Mediastinal, Pigmentation | | 1 4.0|
Pancreatic, Hemorrhage | 2 | 1 2.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 3 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Lymphatic, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 3 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + | 10 |
Developmental Malformation | X | 1 |
Hematopoietic Cell Proliferation | 4 4 | 4 3.3|
Necrosis | | 1 3.0|
Pigmentation, Hemosiderin | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + +| 21 |
Hyperplasia, Cystic | 3 4 3 2 2 2 2 3 1| 15 2.3|
Hyperplasia, Lobular | 3 | 2 2.5|
__________________________________________________________________________|____________|
Skin | | 3 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 6 |
Calvarium, Osteopetrosis | 3 2 3 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 4 |
Compression | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 9| 8| 6| 6| 6| 6| 6| 6| 6| 6| 1| 4| 6| 6| 6| 2| 5| 6| 6| 6| 6| 6| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
20 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 7 |
Congestion | | 1 4.0|
Infiltration Cellular, Histiocyte | 2 | 4 1.5|
Inflammation, Chronic | | 1 1.0|
Inflammation, Suppurative | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 4 | 2 3.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X | 8 |
Foreign Body | 2 | 3 2.0|
Fungus | X X X | 5 |
Inflammation, Chronic | 2 2 2 2 3 2 2 2 2| 13 2.4|
Mucosa, Hyperplasia | 2 2 2 | 5 2.0|
Mucosa, Metaplasia, Squamous | 2 2 | 4 2.0|
Olfactory Epithelium, Pigmentation | 1 2 2 1 1 1 1 1 1 1 2 2 1 1 1 1 2 1 1 2 1 2 2 2| 46 1.4|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Cataract | 3 | 3 3.3|
Phthisis Bulbi | 3 | 1 3.0|
Retina, Atrophy | 3 | 3 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Inflammation, Chronic | 2 3 4 2 2 | 11 2.5|
Inflammation, Suppurative | | 1 1.0|
Mineralization | 2 1 1 1 1 2 1 2 1 1 1 2 1| 24 1.3|
Nephropathy | 1 3 3 2 2 4 1 1 1 3 1 1 1 1 1 2 1 1 2 1 1 1 1 3 1| 48 1.6|
Renal Tubule, Dilatation | 3 | 1 3.0|
Renal Tubule, Pigmentation | 2 2 1 2 2 2 2 3 3 1 2 3 1 2 3 2 2 1 2 2 2 2 2| 43 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 8| 0| 2| 2| 2| 2| 1| 0| 8| 2| 9| 1| 1| 2| 2| 5| 0| 2| 2| 2| 0| 5| 2| 2| 2|
| 4| 4| 9| 9| 9| 7| 7| 2| 9| 9| 4| 1| 8| 9| 9| 1| 5| 9| 9| 9| 7| 3| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | X |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X|
Degeneration, Cystic | |
Eosinophilic Focus | X|
Granuloma | 1 2 1 1 2 1 1 1|
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 2 3 2 2 2 |
Inflammation, Chronic | 2 1 |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 3 3 2 2 2 1 2 3 2 2 2 1 2 3 1 2 1 1 2 2 2 2|
Centrilobular, Atrophy | 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 2 |
Kupffer Cell, Hyperplasia | 3 |
Lobules, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Accessory Spleen | |
Fat, Inflammation, Pyogranulomatous | |
Fat, Necrosis | 2 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 4 1 1 1 1 |
Fibrosis | 3 |
Focal Cellular Change | 1 |
Hyperplasia, Focal | 2 3 2 3 2 3 3 3 3 2 1 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 8| 0| 2| 2| 2| 2| 1| 0| 8| 2| 9| 1| 1| 2| 2| 5| 0| 2| 2| 2| 0| 5| 2| 2| 2|
| 4| 4| 9| 9| 9| 7| 7| 2| 9| 9| 4| 1| 8| 9| 9| 1| 5| 9| 9| 9| 7| 3| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | 4 |
Erosion | 2 |
Inflammation, Chronic | 3 |
Ulcer | 2 4 3 |
Mucosa, Hyperplasia | 2 2 3 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Mineralization | 1 |
Ulcer | 2 2 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Polyarteritis | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 2 1 2 2 2 2 2 1 2 2 1 2|
Thrombosis | |
Epicardium, Inflammation, Chronic | |
Myocardium, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + A + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X|
Angiectasis | |
Clear Cell Focus | X |
Cyst | X |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal | 1 2 1 |
Vacuolization Cytoplasmic, Diffuse | 3 1 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 2 2 1 2 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | 3 |
Hyperplasia | 3 3 2 3 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 1 3 |
Pars Distalis, Pigmentation | 2 2 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 8| 0| 2| 2| 2| 2| 1| 0| 8| 2| 9| 1| 1| 2| 2| 5| 0| 2| 2| 2| 0| 5| 2| 2| 2|
| 4| 4| 9| 9| 9| 7| 7| 2| 9| 9| 4| 1| 8| 9| 9| 1| 5| 9| 9| 9| 7| 3| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 1 |
Follicle, Cyst | X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 |
Foreign Body | 2 |
Inflammation, Chronic | 2 2 3 1 2 2 3 2 2 3 2 3 2 2 2 2|
Inflammation, Suppurative | 2 2 1 1 3 1 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X|
Edema | |
Fibrosis | 3 |
Inflammation, Chronic | 1 1 1 2 |
Inflammation, Suppurative | 1 1 2 2 1 3 1 1 3 3 2 2 2 3 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 1 1 2 2 1 1 1 1 2 3|
Interstitial Cell, Hyperplasia | 3 2 |
Seminiferous Tubule, Atrophy | 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 4 |
Hyperplasia, Reticulum Cell | |
Hypocellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Lymphatic, Dilatation | 3|
Mediastinal, Hemorrhage | 4 3 3 |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage | 3 |
Pancreatic, Hyperplasia, Lymphoid | 2 2 |
Renal, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 8| 0| 2| 2| 2| 2| 1| 0| 8| 2| 9| 1| 1| 2| 2| 5| 0| 2| 2| 2| 0| 5| 2| 2| 2|
| 4| 4| 9| 9| 9| 7| 7| 2| 9| 9| 4| 1| 8| 9| 9| 1| 5| 9| 9| 9| 7| 3| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Lymphatic, Dilatation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 2 2 2 3 2 3 3 2 3 |
Lymphatic, Dilatation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Developmental Malformation | |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 4 4 |
Necrosis | 4 |
Pigmentation, Hemosiderin | 3 3 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + M + + + + + + + +|
Congestion | 3 |
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 3 3 2 4 1 2 3 3 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Cyst Epithelial Inclusion | |
Exudate | X |
Fibrosis | 3 |
Foreign Body | |
Hyperkeratosis | |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hemorrhage | 2 |
Hydrocephalus | 2 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 8| 0| 2| 2| 2| 2| 1| 0| 8| 2| 9| 1| 1| 2| 2| 5| 0| 2| 2| 2| 0| 5| 2| 2| 2|
| 4| 4| 9| 9| 9| 7| 7| 2| 9| 9| 4| 1| 8| 9| 9| 1| 5| 9| 9| 9| 7| 3| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Atelectasis | |
Congestion | 3 3 |
Edema | 2 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 1 1 4 1 1 1 1 1 2 1|
Inflammation, Chronic | 1 1 3 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 3 2 1 |
Mediastinum, Inflammation, | |
Granulomatous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X |
Foreign Body | 2 2 3 |
Fungus | X X X X X |
Inflammation, Chronic | |
Mucosa, Hyperplasia | 3 2 2 |
Mucosa, Metaplasia, Squamous | 3 |
Nerve, Hypertrophy | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Atrophy | 3 |
Sclera, Mineralization | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Inflammation, Chronic | 1 2 2 3 2 2 3 3 3 2 3 3 4 3 4 4 4|
Inflammation, Suppurative | 1 1 1|
Mineralization | 1 2 3 1 1 1 1 1 1 1 1 1 1|
Nephropathy | 1 2 2 3 3 2 3 3 3 2 2 2 4 4 3 3 4 2 3 4 3 2 4 4 4|
Renal Tubule, Pigmentation | |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Ectasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 1| 6| 0| 0| 2| 0| 0| 0| 2| 2| 4| 8| 2| 2| 2| 8| 0| 2| 2| 2| |
| 4| 9| 9| 9| 9| 3| 8| 5| 5| 9| 5| 1| 3| 9| 9| 9| 3| 6| 9| 9| 3| 3| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Parasite Metazoan | X | 2 |
Ulcer | 4 | 2 3.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X | 27 |
Clear Cell Focus | X X X X X | 14 |
Degeneration, Cystic | 3 2 | 2 2.5|
Eosinophilic Focus | X X| 3 |
Granuloma | 2 3 2 1 1 1 3 1 3 2 1 | 19 1.6|
Hematopoietic Cell Proliferation | 3 1 1 2 | 4 1.8|
Hyperplasia, Focal | 2 2 | 7 2.1|
Inflammation, Chronic | 2 3 1 2 | 6 1.8|
Mixed Cell Focus | X | 1 |
Bile Duct, Hyperplasia | 2 2 3 1 2 1 2 2 2 1 1 1 2 2 1 3 2 2 1 2 2 3 1| 45 1.9|
Centrilobular, Atrophy | | 2 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 3 | 8 2.4|
Kupffer Cell, Hyperplasia | 2 2 | 3 2.3|
Lobules, Necrosis | 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 11 |
Accessory Spleen | X | 1 |
Fat, Inflammation, Pyogranulomatous | 3 | 1 3.0|
Fat, Necrosis | 3 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Atrophy | 1 2 3 1 2 3 3 | 14 1.9|
Fibrosis | | 1 3.0|
Focal Cellular Change | | 1 1.0|
Hyperplasia, Focal | 2 4 3 4 2 1 2 3| 19 2.5|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 1| 6| 0| 0| 2| 0| 0| 0| 2| 2| 4| 8| 2| 2| 2| 8| 0| 2| 2| 2| |
| 4| 9| 9| 9| 9| 3| 8| 5| 5| 9| 5| 1| 3| 9| 9| 9| 3| 6| 9| 9| 3| 3| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 4.0|
Erosion | 2 | 2 2.0|
Inflammation, Chronic | | 1 3.0|
Ulcer | | 3 3.0|
Mucosa, Hyperplasia | 3 | 6 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 1 | 3 1.3|
Mineralization | 1 2 1 | 4 1.3|
Ulcer | | 3 2.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 4 |
Polyarteritis | 3 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 2 3 3 3 1 3 2 2 2 2 2 2 3 2 3 2 | 33 2.2|
Thrombosis | X | 1 |
Epicardium, Inflammation, Chronic | 2 | 1 2.0|
Myocardium, Inflammation, Chronic | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | X X X X X X| 14 |
Angiectasis | 2 2 2 2 | 4 2.0|
Clear Cell Focus | X X X | 4 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Hyperplasia, Focal | 2 1 1 2 | 7 1.4|
Vacuolization Cytoplasmic, Diffuse | | 3 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 1 1 2 1 3 1 1| 23 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 1| 6| 0| 0| 2| 0| 0| 0| 2| 2| 4| 8| 2| 2| 2| 8| 0| 2| 2| 2| |
| 4| 9| 9| 9| 9| 3| 8| 5| 5| 9| 5| 1| 3| 9| 9| 9| 3| 6| 9| 9| 3| 3| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Cyst | | 1 |
Hemorrhage | | 1 3.0|
Hyperplasia | 3 3 1 | 8 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Cyst | X X X X| 5 |
Pars Distalis, Hyperplasia | 2 1 1 2 1| 9 1.7|
Pars Distalis, Pigmentation | | 2 2.0|
Pars Intermedia, Angiectasis | | 1 2.0|
Pars Intermedia, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 2 3 2| 9 1.9|
Follicle, Cyst | | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 3 | 4 2.8|
Foreign Body | | 1 2.0|
Inflammation, Chronic | 3 2 3 2 2 2 3 2 2 2 2 2| 28 2.2|
Inflammation, Suppurative | 2 3 4 1 | 11 2.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 2 |
Edema | 4 | 1 4.0|
Fibrosis | 3 | 2 3.0|
Inflammation, Chronic | 3 2 1 | 7 1.6|
Inflammation, Suppurative | 2 2 2 1 3 1 1 4 1 1| 25 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 4 | 1 4.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 2 1 1 2 1 1 1 1 1 1 3 2 | 26 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 1| 6| 0| 0| 2| 0| 0| 0| 2| 2| 4| 8| 2| 2| 2| 8| 0| 2| 2| 2| |
| 4| 9| 9| 9| 9| 3| 8| 5| 5| 9| 5| 1| 3| 9| 9| 9| 3| 6| 9| 9| 3| 3| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | | 2 2.5|
Seminiferous Tubule, Atrophy | 1 4 4 | 5 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 3| 2 3.5|
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
Hypocellularity | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Lymphatic, Dilatation | | 1 3.0|
Mediastinal, Hemorrhage | 3 3 3 2 3| 8 3.0|
Mediastinal, Pigmentation | 3 2 3 2 | 4 2.5|
Pancreatic, Hemorrhage | | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 2 2.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Lymphatic, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 2 2.5|
Hyperplasia, Plasma Cell | 2 3 2 3 2 3 1 2 2| 19 2.4|
Lymphatic, Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erythrophagocytosis | 3 | 1 3.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 1 | 2 2.0|
Developmental Malformation | X | 1 |
Fibrosis | 2 | 2 2.5|
Hematopoietic Cell Proliferation | 2 4 2 2 2 2 | 9 2.7|
Necrosis | | 1 4.0|
Pigmentation, Hemosiderin | 3 | 5 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + I + + + + + +| 46 |
Congestion | | 1 3.0|
Cyst | X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + M + +| 48 |
Hyperplasia, Cystic | 1 2 2 2 1 1 1| 17 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 1| 6| 0| 0| 2| 0| 0| 0| 2| 2| 4| 8| 2| 2| 2| 8| 0| 2| 2| 2| |
| 4| 9| 9| 9| 9| 3| 8| 5| 5| 9| 5| 1| 3| 9| 9| 9| 3| 6| 9| 9| 3| 3| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Acanthosis | 4 | 2 4.0|
Cyst Epithelial Inclusion | X | 1 |
Exudate | | 1 |
Fibrosis | | 1 3.0|
Foreign Body | 4 | 1 4.0|
Hyperkeratosis | 4 | 1 4.0|
Inflammation, Granulomatous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 6 |
Hemorrhage | | 1 2.0|
Hydrocephalus | | 1 2.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atelectasis | 3 | 1 3.0|
Congestion | | 2 3.0|
Edema | 3 | 3 2.3|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 2 1 1 2 1 1 3 1 1 1 3 1 1 1 3 1| 33 1.4|
Inflammation, Chronic | 1 2 3 1 | 7 1.7|
Inflammation, Suppurative | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 3 | 6 2.2|
Mediastinum, Inflammation, | | |
Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X X X X X X X| 17 |
Foreign Body | 3 2 1 3 2| 8 2.3|
Fungus | X X 4 X X X X X X | 14 4.0|
Inflammation, Chronic | 2 3 | 2 2.5|
Mucosa, Hyperplasia | 3 3 2 3 2| 8 2.5|
Mucosa, Metaplasia, Squamous | 3 2 3 2 | 5 2.6|
Nerve, Hypertrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 1| 6| 0| 0| 2| 0| 0| 0| 2| 2| 4| 8| 2| 2| 2| 8| 0| 2| 2| 2| |
| 4| 9| 9| 9| 9| 3| 8| 5| 5| 9| 5| 1| 3| 9| 9| 9| 3| 6| 9| 9| 3| 3| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | | 1 3.0|
Retina, Atrophy | 3 | 2 3.0|
Sclera, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 2 |
Infarct | 2 | 1 2.0|
Inflammation, Chronic | 3 2 2 4 2 3 1 4 2 2 1 2 3 2 3 4 1 2 3 3 4| 38 2.7|
Inflammation, Suppurative | 3 2 2 1 1 1 1| 10 1.4|
Mineralization | 1 1 1 2 1 1 1| 20 1.2|
Nephropathy | 3 3 2 4 2 3 3 4 3 1 2 1 2 4 3 3 4 2 4 1 2 3 3 3| 49 2.8|
Renal Tubule, Pigmentation | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urethra | + + | 2 |
Bulbourethral Gland, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 7| 0| 0| 0| 0| 0| 0| 6| 6| 6| 7| 0| 0| 0| 0| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 6| 1| 8| 9| 3| 6| 6| 6| 6| 6| 9| 3| 3| 9| 3| 9| 9| 9| 9| 3| 8| 8| 0| 3| 3|
| 0| 4| 4| 7| 0| 6| 6| 6| 7| 7| 7| 5| 6| 6| 0| 6| 6| 6| 6| 0| 5| 5| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
40 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | X |
Lymphatic, Dilatation | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X |
Clear Cell Focus | X X|
Congestion | 3 2 3 2 2 3 2 2 2 |
Degeneration, Cystic | 2 2 1 |
Eosinophilic Focus | |
Granuloma | 1 1|
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal | 2 3 |
Inflammation, Chronic | 2 2|
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 2 3 2 4 2 1 2 3 1 1 2 1|
Centrilobular, Necrosis | 1 1 1 2 2 2 1 1 1 1 1 |
Hepatocyte, Pigmentation | 1 1 1|
Hepatocyte, Vacuolization Cytoplasmic| |
Lobules, Necrosis | |
Periportal, Inflammation, Chronic | |
Active | 1 |
Portal, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Fat, Necrosis | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 2 |
Cytoplasmic Alteration | |
Edema | 3 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 7| 0| 0| 0| 0| 0| 0| 6| 6| 6| 7| 0| 0| 0| 0| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 6| 1| 8| 9| 3| 6| 6| 6| 6| 6| 9| 3| 3| 9| 3| 9| 9| 9| 9| 3| 8| 8| 0| 3| 3|
| 0| 4| 4| 7| 0| 6| 6| 6| 7| 7| 7| 5| 6| 6| 0| 6| 6| 6| 6| 0| 5| 5| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
40 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Ulcer | 3 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + +|
Polyarteritis | 2 2|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cardiomyopathy | 1 2 1 2 1 2 3 1 1 |
Myocardium, Inflammation, Chronic | 1 2 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X|
Angiectasis | 2 3 |
Clear Cell Focus | X |
Congestion | 3 3 |
Hemorrhage | 3 3 |
Hyperplasia, Focal | 2 |
Vacuolization Cytoplasmic, Diffuse | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia | 2 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 7| 0| 0| 0| 0| 0| 0| 6| 6| 6| 7| 0| 0| 0| 0| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 6| 1| 8| 9| 3| 6| 6| 6| 6| 6| 9| 3| 3| 9| 3| 9| 9| 9| 9| 3| 8| 8| 0| 3| 3|
| 0| 4| 4| 7| 0| 6| 6| 6| 7| 7| 7| 5| 6| 6| 0| 6| 6| 6| 6| 0| 5| 5| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
40 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2|
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 1 3 1 2 2 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 1 1 1 2|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 4 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 3 |
Hyperplasia, Reticulum Cell | 2 |
Lymphatic, Dilatation | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 |
Necrosis | 1 |
Lymphatic, Dilatation | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + I + + + + +|
Congestion | 3 2 3 3 3 4 3 3 |
Cyst | |
Ectopic Parathyroid Gland | X |
Hemorrhage | 3 3 2 3 3 3 4 3 4 2 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 7| 0| 0| 0| 0| 0| 0| 6| 6| 6| 7| 0| 0| 0| 0| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 6| 1| 8| 9| 3| 6| 6| 6| 6| 6| 9| 3| 3| 9| 3| 9| 9| 9| 9| 3| 8| 8| 0| 3| 3|
| 0| 4| 4| 7| 0| 6| 6| 6| 7| 7| 7| 5| 6| 6| 0| 6| 6| 6| 6| 0| 5| 5| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
40 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Cystic | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | X |
Exudate | |
Inflammation, Chronic | |
Scrotum, Congestion | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Congestion | 3 2 2 3 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 3 3 3 3 3 3 4 3 4 3 3 3 2 2 3 3 |
Edema | 2 2 2 |
Foreign Body | 3 |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 2 2 1|
Inflammation, Chronic | 1 2 1 2 |
Inflammation, Subacute | |
Inflammation, Suppurative | 1 |
Metaplasia, Osseous | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Exudate | X X X|
Foreign Body | 2 2 |
Fungus | X X X|
Inflammation, Chronic | 2 3 |
Mucosa, Erosion | |
Mucosa, Hyperplasia | 2 2 |
Mucosa, Metaplasia, Squamous | 3 3|
Olfactory Epithelium, Pigmentation | 2 2 2 3 2 1 1 2 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 0| 5| 6| 6| 7| 0| 0| 0| 0| 0| 0| 6| 6| 6| 7| 0| 0| 0| 0| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 6| 1| 8| 9| 3| 6| 6| 6| 6| 6| 9| 3| 3| 9| 3| 9| 9| 9| 9| 3| 8| 8| 0| 3| 3|
| 0| 4| 4| 7| 0| 6| 6| 6| 7| 7| 7| 5| 6| 6| 0| 6| 6| 6| 6| 0| 5| 5| 2| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
40 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Phthisis Bulbi | |
Retina, Atrophy | |
Sclera, Mineralization | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Inflammation, Chronic | 2 3 2 3 2 2 3 3 4 2|
Inflammation, Suppurative | 1 1 1 2 2 1|
Mineralization | 1 1 |
Nephropathy | 2 3 2 3 2 2 2 2 4 1 3 4 2|
Artery, Hypertrophy | 4 |
Renal Tubule, Pigmentation | 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 1| 1| 1| 1| 1| 0| 6| 4| 7| 7| 2| 2| 5| 7| 7| 1| 1| 5| 7| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 0| 0| 0| 0| 1| 9| 9| 8| 3| 3| 0| 0| 9| 3| 3| 0| 0| 4| 0| 3| |
| 7| 0| 0| 0| 0| 8| 8| 8| 9| 0| 6| 7| 8| 0| 0| 6| 6| 2| 0| 0| 9| 9| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
40 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M M + M + + + + + + + + + + + + + +| 47 |
Edema | 3 | 1 3.0|
Parasite Metazoan | X X | 3 |
Lymphatic, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 1.5|
Basophilic Focus | X X X X X| 8 |
Clear Cell Focus | X X | 4 |
Congestion | 2 3 2 2 | 13 2.3|
Degeneration, Cystic | 1 2 1| 6 1.5|
Eosinophilic Focus | X | 1 |
Granuloma | 1 1 1 1 1 1| 8 1.0|
Hepatodiaphragmatic Nodule | X | 1 |
Hyperplasia, Focal | | 2 2.5|
Inflammation, Chronic | 1 2 | 4 1.8|
Mixed Cell Focus | X | 1 |
Bile Duct, Hyperplasia | 3 2 1 3 3 1 1 2 3 1 1 3 1 1| 26 1.9|
Centrilobular, Necrosis | 1 2 2 3 2 3 | 17 1.6|
Hepatocyte, Pigmentation | 1 | 4 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 | 2 1.5|
Lobules, Necrosis | 1 | 1 1.0|
Periportal, Inflammation, Chronic | | |
Active | | 1 1.0|
Portal, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 9 |
Fat, Necrosis | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 1 3 1| 9 1.8|
Cytoplasmic Alteration | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 1| 1| 1| 1| 1| 0| 6| 4| 7| 7| 2| 2| 5| 7| 7| 1| 1| 5| 7| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 0| 0| 0| 0| 1| 9| 9| 8| 3| 3| 0| 0| 9| 3| 3| 0| 0| 4| 0| 3| |
| 7| 0| 0| 0| 0| 8| 8| 8| 9| 0| 6| 7| 8| 0| 0| 6| 6| 2| 0| 0| 9| 9| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
40 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | | 1 3.0|
Hyperplasia, Focal | 3| 1 3.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
Ulcer | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Tongue | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 5 |
Polyarteritis | 3 3 2 | 5 2.4|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Cardiomyopathy | 2 1 2 1 3 2 2 2 2 3 1 3| 21 1.8|
Myocardium, Inflammation, Chronic | 2 2 2 | 7 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X | 6 |
Angiectasis | 2 2 | 4 2.3|
Clear Cell Focus | X X | 3 |
Congestion | | 2 3.0|
Hemorrhage | 2 4 3 | 5 3.0|
Hyperplasia, Focal | 3 | 2 2.5|
Vacuolization Cytoplasmic, Diffuse | 3 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 3.0|
Hyperplasia | 1 2 1 2 2 1| 9 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 3 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 4 1 | 2 2.5|
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 1| 1| 1| 1| 1| 0| 6| 4| 7| 7| 2| 2| 5| 7| 7| 1| 1| 5| 7| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 0| 0| 0| 0| 1| 9| 9| 8| 3| 3| 0| 0| 9| 3| 3| 0| 0| 4| 0| 3| |
| 7| 0| 0| 0| 0| 8| 8| 8| 9| 0| 6| 7| 8| 0| 0| 6| 6| 2| 0| 0| 9| 9| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
40 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Intermedia, Angiectasis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 2 1| 4 1.5|
Follicle, Cyst | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 2 2 2 3| 15 2.1|
Inflammation, Suppurative | 1 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 1 | 4 1.8|
Inflammation, Suppurative | 2 1 2 2 3 3 2 3 1 | 15 1.9|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 1 1 3 1 1 1| 14 1.5|
Interstitial Cell, Hyperplasia | 1 2 | 2 1.5|
Seminiferous Tubule, Atrophy | 4 3 | 5 3.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Congestion | 2 | 1 2.0|
Mediastinal, Hemorrhage | 4 | 1 4.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 3 2 2 | 5 2.4|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 3 3 3 | 3 3.0|
Hyperplasia, Plasma Cell | 2 4 2 | 5 2.6|
Hyperplasia, Reticulum Cell | | 1 2.0|
Lymphatic, Dilatation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Congestion | | 1 2.0|
Hemorrhage | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 1| 1| 1| 1| 1| 0| 6| 4| 7| 7| 2| 2| 5| 7| 7| 1| 1| 5| 7| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 0| 0| 0| 0| 1| 9| 9| 8| 3| 3| 0| 0| 9| 3| 3| 0| 0| 4| 0| 3| |
| 7| 0| 0| 0| 0| 8| 8| 8| 9| 0| 6| 7| 8| 0| 0| 6| 6| 2| 0| 0| 9| 9| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
40 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Necrosis | 1 | 2 1.0|
Lymphatic, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Congestion | 3 4 3 3 3 | 13 3.1|
Cyst | X | 1 |
Ectopic Parathyroid Gland | | 1 |
Hemorrhage | 2 3 2 3 3 4 3 3 3 | 21 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Cystic | 2 3 1 | 4 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 | 1 2.0|
Cyst Epithelial Inclusion | | 1 |
Exudate | X | 1 |
Inflammation, Chronic | 2 | 1 2.0|
Scrotum, Congestion | 2 2 2 2 2 3 3 2 2 | 13 2.2|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 2 |
Congestion | 2 2 3 2 2 3 2 3 3 2 2 2 | 21 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 3 3 3 3 3 4 3 3 3 3 3 | 30 3.1|
Edema | 2 2 | 5 2.0|
Foreign Body | 2 | 2 2.5|
Hemorrhage | 2 | 2 2.5|
Infiltration Cellular, Histiocyte | 1 1 1 1 2 3 2 1 1 1 1 1 2 2 2| 23 1.4|
Inflammation, Chronic | 1 1 | 6 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 1| 1| 1| 1| 1| 0| 6| 4| 7| 7| 2| 2| 5| 7| 7| 1| 1| 5| 7| 7| |
DAY ON TEST | 9| 3| 3| 3| 3| 0| 0| 0| 0| 1| 9| 9| 8| 3| 3| 0| 0| 9| 3| 3| 0| 0| 4| 0| 3| |
| 7| 0| 0| 0| 0| 8| 8| 8| 9| 0| 6| 7| 8| 0| 0| 6| 6| 2| 0| 0| 9| 9| 8| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
40 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Subacute | 3 | 1 3.0|
Inflammation, Suppurative | | 1 1.0|
Metaplasia, Osseous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 4 | 3 3.7|
Exudate | X X X X X X| 9 |
Foreign Body | | 2 2.0|
Fungus | X X X | 6 |
Inflammation, Chronic | 2 3 2 | 5 2.4|
Mucosa, Erosion | 2 | 1 2.0|
Mucosa, Hyperplasia | 3 | 3 2.3|
Mucosa, Metaplasia, Squamous | 2 3 3 | 5 2.8|
Olfactory Epithelium, Pigmentation | 2 2 1 2 2 1 1 1 1 2 2 2 2| 25 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Cataract | 3 | 1 3.0|
Phthisis Bulbi | 3 | 1 3.0|
Retina, Atrophy | 4 | 1 4.0|
Sclera, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Cyst | X | 1 |
Inflammation, Chronic | 3 2 2 2 2 2 3 2 4 3| 20 2.6|
Inflammation, Suppurative | 3 3 2 1 1 1 2 2| 14 1.6|
Mineralization | 2 1 1 1 1 1| 8 1.1|
Nephropathy | 3 3 3 2 3 1 3 3 1 3 4 1 1 4| 27 2.5|
Artery, Hypertrophy | | 1 4.0|
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2| 16 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 1| 1| 1| 1| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 8| 8| 8| 0| 9| 6| 2| 1| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 8| 5| 8| 1| 3|
| 5| 5| 5| 5| 5| 3| 8| 8| 8| 2| 3| 2| 2| 2| 2| 9| 4| 2| 2| 2| 7| 4| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
20 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + + + + A + +|
Edema | |
Parasite Metazoan | X X |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + A + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Congestion | |
Degeneration, Cystic | 2 1 1 1 1 |
Eosinophilic Focus | X X |
Granuloma | 1 2 3 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 1 1 2 2 |
Inflammation, Chronic Active | |
Bile Duct, Hyperplasia | 2 1 1 3 1 3 3 2 2 1 2 1 2 2 3 2 1 2 3 1 3|
Centrilobular, Atrophy | 3 2 |
Centrilobular, Necrosis | 1 1 1 |
Hepatocyte, Pigmentation | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Kupffer Cell, Hyperplasia | 2 2 |
Lobules, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 1 1 1 3 1 3 1 |
Cytoplasmic Alteration | 3 |
Focal Cellular Change | X |
Hyperplasia, Focal | 2 3 3 3|
Inflammation, Chronic | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 1| 1| 1| 1| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 8| 8| 8| 0| 9| 6| 2| 1| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 8| 5| 8| 1| 3|
| 5| 5| 5| 5| 5| 3| 8| 8| 8| 2| 3| 2| 2| 2| 2| 9| 4| 2| 2| 2| 7| 4| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
20 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 3 |
Edema | 2 |
Erosion | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 |
Ulcer | 4 |
Mucosa, Hyperplasia | 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 |
Erosion | 2 |
Hemorrhage | 1 |
Mineralization | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Polyarteritis | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 1 2 2 1 2 2 1 1 3 3 3 3|
Thrombosis | X |
Myocardium, Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X|
Angiectasis | |
Clear Cell Focus | X |
Congestion | 2 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 3 2 |
Necrosis | 3 |
Vacuolization Cytoplasmic, Diffuse | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 1 2 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 1| 1| 1| 1| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 8| 8| 8| 0| 9| 6| 2| 1| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 8| 5| 8| 1| 3|
| 5| 5| 5| 5| 5| 3| 8| 8| 8| 2| 3| 2| 2| 2| 2| 9| 4| 2| 2| 2| 7| 4| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
20 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 1 |
Pars Distalis, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Foreign Body | 2 |
Inflammation, Chronic | 2 2 2 2 2 3 2 2 2 1|
Inflammation, Suppurative | 2 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Chronic | 1 1 1|
Inflammation, Suppurative | 2 1 1 3 2 1 1 3 3 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 3 2 1 1 2 2 2 2 1 2 2 2|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 4 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 4 |
Hypocellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | 2 2 2 3 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 4 3 |
Hyperplasia, Plasma Cell | 4 4 2 2 4 3 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 1| 1| 1| 1| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 8| 8| 8| 0| 9| 6| 2| 1| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 8| 5| 8| 1| 3|
| 5| 5| 5| 5| 5| 3| 8| 8| 8| 2| 3| 2| 2| 2| 2| 9| 4| 2| 2| 2| 7| 4| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
20 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, | |
Polymorphonuclear | 3 |
Lymphatic, Dilatation | 3 3 2 2 3 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 3 |
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Reticulum Cell | 2 |
Necrosis | 1 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Degeneration, Fatty | |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 3 3 3 |
Hemorrhage | 4 |
Hyperplasia, Mononuclear Cell | 3 |
Hyperplasia, Re Cell | |
Necrosis | 3 |
Pigmentation, Hemosiderin | 3 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + M + M +|
Congestion | 2 3 3 2 |
Cyst | |
Hemorrhage | 3 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 1 1 2 |
Hyperplasia, Lobular | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Angiectasis | |
Cyst Epithelial Inclusion | |
Hyperkeratosis | 4 |
Inflammation, Chronic | 1 |
Ulcer | |
Lip, Hemorrhage | 2 |
Scrotum, Congestion | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 1| 1| 1| 1| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 8| 8| 8| 8| 0| 9| 6| 2| 1| 3| 0| 3| 3| 3| 3| 0| 0| 3| 3| 3| 8| 5| 8| 1| 3|
| 5| 5| 5| 5| 5| 3| 8| 8| 8| 2| 3| 2| 2| 2| 2| 9| 4| 2| 2| 2| 7| 4| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
20 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Congestion | 2 2 2 2 |
Degeneration, Focal | |
Hemorrhage | 4 3 |
Hydrocephalus | |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 3 |
Edema | 2 |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Inflammation, Chronic | 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X |
Foreign Body | 2 2 2 2 |
Fungus | X X X X X X X |
Inflammation, Chronic | 4 3 2 2 3 2 3 |
Mucosa, Hyperplasia | 3 3 2 2 3 |
Mucosa, Metaplasia, Squamous | 3 2 2 2 4 |
Olfactory Epithelium, Pigmentation | 1 1 1 1 1 2 1 2 1 1 2 2 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hydronephrosis | |
Infarct | |
Inflammation, Chronic | 3 2 3 3 2 2 3 3 3 2 4 3 2 2 2 2|
Inflammation, Suppurative | 1 2 2 1 2 2 1 1 2 1|
Mineralization | 1 1 1 1 1 1 1|
Nephropathy | 1 1 3 1 1 2 4 3 2 2 2 3 4 1 3 3 3 3 2 3 2 3 3|
Renal Tubule, Pigmentation | 2 1 2 1 2 2 2|
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 5| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 8| 7| 3| 3| 3| 8| 0| 3| 3| 3| 9| 3| 3| 3| 3| 8| 0| 1| 3| 3| |
| 1| 2| 3| 3| 3| 6| 8| 3| 3| 3| 4| 4| 3| 3| 3| 7| 3| 3| 3| 3| 5| 7| 9| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
20 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Edema | 3 | 1 3.0|
Parasite Metazoan | X | 3 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + I + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | X X X X X X X X X X X X X| 26 |
Clear Cell Focus | X X X | 6 |
Congestion | 3 3 | 2 3.0|
Degeneration, Cystic | 1 3 2 2 | 9 1.6|
Eosinophilic Focus | X X X X X X X | 9 |
Granuloma | 2 1 2 | 6 1.8|
Hematopoietic Cell Proliferation | 2 1 | 2 1.5|
Hepatodiaphragmatic Nodule | X X | 2 |
Inflammation, Chronic | 1 1 2 2 2| 9 1.6|
Inflammation, Chronic Active | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 3 1 2 1 3 2 2 1 1 2 2 2 2 2 2 3 3 2 1 3 4 3| 44 2.0|
Centrilobular, Atrophy | 2 2 2 | 5 2.2|
Centrilobular, Necrosis | 2 3 1 | 6 1.5|
Hepatocyte, Pigmentation | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| | 1 3.0|
Kupffer Cell, Hyperplasia | 2 2 | 4 2.0|
Lobules, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 5 |
Fat, Necrosis | 2 4 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 1 3 1 2 1 1 2 1 2 | 19 1.7|
Cytoplasmic Alteration | 3 | 2 3.0|
Focal Cellular Change | 1 X | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 5| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 8| 7| 3| 3| 3| 8| 0| 3| 3| 3| 9| 3| 3| 3| 3| 8| 0| 1| 3| 3| |
| 1| 2| 3| 3| 3| 6| 8| 3| 3| 3| 4| 4| 3| 3| 3| 7| 3| 3| 3| 3| 5| 7| 9| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
20 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Focal | 2 1 2 1| 8 2.1|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia | | 1 3.0|
Edema | 3 2 2 | 4 2.3|
Erosion | 3 2 | 2 2.5|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | 3 | 2 3.5|
Mucosa, Hyperplasia | 3 3 1 | 5 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 1.0|
Erosion | 2 | 2 2.0|
Hemorrhage | | 1 1.0|
Mineralization | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + M + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 5 |
Polyarteritis | 2 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 3 3 2 3 2 3 3 3 2 2 2 3 2 2 3 2 3 2 3 3 | 36 2.3|
Thrombosis | | 1 |
Myocardium, Inflammation, Chronic | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X | 8 |
Angiectasis | 2 3 | 2 2.5|
Clear Cell Focus | X X X X | 5 |
Congestion | | 2 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Diffuse | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 5| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 8| 7| 3| 3| 3| 8| 0| 3| 3| 3| 9| 3| 3| 3| 3| 8| 0| 1| 3| 3| |
| 1| 2| 3| 3| 3| 6| 8| 3| 3| 3| 4| 4| 3| 3| 3| 7| 3| 3| 3| 3| 5| 7| 9| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
20 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia, Focal | 2 3 2 2 1 | 7 2.1|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 3 2 1 2 2 2 1| 16 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 1 |
Hyperplasia | 2 2 2 | 8 1.6|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | X X | 4 |
Pars Distalis, Hyperplasia | 2 1 2 | 5 1.6|
Pars Distalis, Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 3 3 | 5 2.4|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 2.0|
Foreign Body | | 1 2.0|
Inflammation, Chronic | 3 2 3 2 2 2 2 3 2 3 2 3 3 2 2 2 2 2 2| 29 2.2|
Inflammation, Suppurative | 3 2 3 2 2 | 7 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Inflammation, Chronic | 1 1 | 5 1.0|
Inflammation, Suppurative | 3 1 3 1 2 1 1 1 1 3 | 20 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 1 1 1 2 3 2 1 1 3 2 2 1 2 2| 29 1.7|
Interstitial Cell, Hyperplasia | 1 1 | 2 1.0|
Seminiferous Tubule, Atrophy | 4 4 4 4 | 7 3.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 5| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 8| 7| 3| 3| 3| 8| 0| 3| 3| 3| 9| 3| 3| 3| 3| 8| 0| 1| 3| 3| |
| 1| 2| 3| 3| 3| 6| 8| 3| 3| 3| 4| 4| 3| 3| 3| 7| 3| 3| 3| 3| 5| 7| 9| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
20 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 3 4 2 3 | 6 3.2|
Hypocellularity | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Mediastinal, Hemorrhage | 4 3 2 3 3 | 10 2.7|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 2 | 1 2.0|
Mediastinal, Pigmentation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 2 2.0|
Hemorrhage | 3 | 2 2.5|
Hyperplasia, Lymphoid | | 2 3.5|
Hyperplasia, Plasma Cell | 3 2 3 3 4 3 3 | 17 2.9|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Lymphatic, Dilatation | 3 3 3 3 | 10 2.9|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 3 2 1 | 6 2.5|
Hyperplasia, Lymphoid | | 1 4.0|
Hyperplasia, Reticulum Cell | | 1 2.0|
Necrosis | | 1 1.0|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Degeneration, Fatty | 4 | 1 4.0|
Fibrosis | 2 3 | 3 2.7|
Hematopoietic Cell Proliferation | 3 2 3 | 7 2.9|
Hemorrhage | | 1 4.0|
Hyperplasia, Mononuclear Cell | | 1 3.0|
Hyperplasia, Re Cell | 4 3 | 2 3.5|
Necrosis | 2 1 | 3 2.0|
Pigmentation, Hemosiderin | 3 3 3 2 3 | 8 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Congestion | 2 | 5 2.4|
Cyst | X | 1 |
Hemorrhage | 2 | 5 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 5| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 8| 7| 3| 3| 3| 8| 0| 3| 3| 3| 9| 3| 3| 3| 3| 8| 0| 1| 3| 3| |
| 1| 2| 3| 3| 3| 6| 8| 3| 3| 3| 4| 4| 3| 3| 3| 7| 3| 3| 3| 3| 5| 7| 9| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
20 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 3 1 2 3 4 2 | 11 2.1|
Hyperplasia, Lobular | | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 4.0|
Angiectasis | 2 | 1 2.0|
Cyst Epithelial Inclusion | X X | 2 |
Hyperkeratosis | | 1 4.0|
Inflammation, Chronic | | 1 1.0|
Ulcer | 3 | 1 3.0|
Lip, Hemorrhage | | 1 2.0|
Scrotum, Congestion | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X | 3 |
Congestion | | 4 2.0|
Degeneration, Focal | 2 | 1 2.0|
Hemorrhage | 4 2 | 4 3.3|
Hydrocephalus | 2 | 1 2.0|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 6 2.7|
Edema | | 1 2.0|
Hemorrhage | | 2 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 3 1 1 1 1 1 2 1 1 1 1| 28 1.1|
Inflammation, Chronic | 1 1 2 1 | 10 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X | 12 |
Foreign Body | 2 | 5 2.0|
Fungus | X X X X | 11 |
Inflammation, Chronic | 3 3 3 3 | 11 2.8|
Mucosa, Hyperplasia | 3 3 | 7 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 5| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 8| 7| 3| 3| 3| 8| 0| 3| 3| 3| 9| 3| 3| 3| 3| 8| 0| 1| 3| 3| |
| 1| 2| 3| 3| 3| 6| 8| 3| 3| 3| 4| 4| 3| 3| 3| 7| 3| 3| 3| 3| 5| 7| 9| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
20 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Metaplasia, Squamous | 3 3 2 3 | 9 2.7|
Olfactory Epithelium, Pigmentation | 1 1 1 1 1 1 1 1 2 1 2 2 1 1 2 1 1 2 1 1 1 1| 40 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 3.0|
Retina, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 3 |
Hydronephrosis | 4 | 1 4.0|
Infarct | 4 | 1 4.0|
Inflammation, Chronic | 3 3 2 2 2 3 2 4 3 4 1 3 3 3| 30 2.6|
Inflammation, Suppurative | 2 2 1 1 2 1 1 1 1 2 | 20 1.5|
Mineralization | 1 1 1 1 1 1 1 1 | 15 1.0|
Nephropathy | 3 3 2 3 3 1 3 2 3 3 4 4 2 4 2 2 2 2 3 2 3 2 2| 46 2.5|
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2| 22 1.8|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 4| 6| 6| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 8| 3| 3| 3| 8| 0| 2| 2| 2| 2| 3| 3| 3|
| 0| 7| 7| 7| 7| 7| 3| 7| 7| 7| 8| 8| 4| 7| 7| 5| 8| 4| 7| 4| 1| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X|
Congestion | 2 |
Degeneration, Cystic | 1 1 2 2 1 |
Eosinophilic Focus | X X X X X |
Granuloma | 2 3 1 1 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | 3 2 2 3 |
Inflammation, Chronic | 1 2 2 |
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 1 3 3 2 2 3 3 3 2 3 2 2 1 2 3 2 1 3 2 3 2 2 2 2|
Centrilobular, Necrosis | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation | |
Lobules, Necrosis | 1 3 1 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | |
Fat, Necrosis | 4 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 3 2 1 2|
Cytoplasmic Alteration | 2 4 |
Hyperplasia, Focal | 2 3 2 2 3 1 1 3|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Chronic | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 4| 6| 6| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 8| 3| 3| 3| 8| 0| 2| 2| 2| 2| 3| 3| 3|
| 0| 7| 7| 7| 7| 7| 3| 7| 7| 7| 8| 8| 4| 7| 7| 5| 8| 4| 7| 4| 1| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 1 |
Mucosa, Hyperplasia | 2 2 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 3 |
Inflammation, Chronic Active | |
Mineralization | 1 1 |
Ulcer | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Polyarteritis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 3 3 2 2 1 2 2 3 2 3 1 1 1|
Myocardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X |
Angiectasis | 2 3 |
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Focal | 3 1 1 1 1 3 |
Necrosis | |
Vacuolization Cytoplasmic, Diffuse | 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X |
Hyperplasia | 1 3 1 1 1 2 1 2 3 1 1 1 3 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2|
Pars Distalis, Cyst | X X|
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 1 1 1 2|
Pars Distalis, Necrosis | |
Pars Intermedia, Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 4| 6| 6| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 8| 3| 3| 3| 8| 0| 2| 2| 2| 2| 3| 3| 3|
| 0| 7| 7| 7| 7| 7| 3| 7| 7| 7| 8| 8| 4| 7| 7| 5| 8| 4| 7| 4| 1| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Nervosa, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 2 1 1 2 1 1 |
Follicle, Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Ectasia | 2 |
Inflammation, Chronic | 3 2 2 4 2 2 2 2 3 2 3 3 2 3|
Inflammation, Suppurative | 1 2 2 1 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic | |
Inflammation, Suppurative | 1 3 1 1 2 3 1 3 4 1 2 2 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 1 1 2 3 1 1 1 3 2 |
Interstitial Cell, Hyperplasia | 1 |
Seminiferous Tubule, Atrophy | 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
Hyperplasia, Reticulum Cell | 3 |
Hypocellularity | |
Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Hemorrhage | 3 2 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 2 |
Mediastinal, Pigmentation | 3 3 3 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 4 2 2 3 3 3 3|
Lymphatic, Dilatation | 3 3 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 4| 6| 6| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 8| 3| 3| 3| 8| 0| 2| 2| 2| 2| 3| 3| 3|
| 0| 7| 7| 7| 7| 7| 3| 7| 7| 7| 8| 8| 4| 7| 7| 5| 8| 4| 7| 4| 1| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphatic, Dilatation | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Re Cell | |
Necrosis | |
Pigmentation, Hemosiderin | 3 2 2 |
Lymphoid Follicle, Atrophy | |
Red Pulp, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Cystic | 2 1 1 2 1 2 |
Hyperplasia, Lobular | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia, Basal Cell | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Congestion | 2 |
Hemorrhage | 3 |
Hydrocephalus | |
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Edema | 3 2 |
Foreign Body | 3 |
Hemorrhage | 1 2 |
Infiltration Cellular, Histiocyte | 1 2 2 1 1 3 1 1 1 1 2 1 |
Inflammation, Chronic | 1 1 2 1 1 1 |
Inflammation, Suppurative | |
Leukocytosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 5| 6| 7| 7| 4| 4| 6| 6| 7| 5| 6| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 9| 8| 3| 3| 3| 8| 0| 2| 2| 2| 2| 3| 3| 3|
| 0| 7| 7| 7| 7| 7| 3| 7| 7| 7| 8| 8| 4| 7| 7| 5| 8| 4| 7| 4| 1| 5| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X |
Foreign Body | 3 2 4 2 |
Fungus | X X X X X X |
Inflammation, Chronic | 3 2 3 4 |
Pigmentation | 1 |
Mucosa, Hyperplasia | 3 3 3 |
Mucosa, Metaplasia, Squamous | 3 3 2 4 |
Nerve, Hypertrophy | |
Olfactory Epithelium, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 3 3 3 |
Cornea, Hyperplasia | 1 |
Retina, Atrophy | 4 4 4 |
Sclera, Mineralization | 3 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 2 3 4 3 2 2 2 2 2 3 4 3 1 2 3 3 2 2|
Inflammation, Suppurative | 2 2 1 2 2 2 2 1 1|
Mineralization | 1 1 1 1 1 |
Nephropathy | 2 3 3 4 3 2 2 3 2 3 1 2 4 4 3 2 2 2 3 1 3 3 3 2|
Renal Tubule, Pigmentation | 1 1 1 1 2 1 1 1 1 1 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 2| 7| 1| 3| 7| 3| 7| 8| 3| 3| 7| 2| 4| 0| 3| 3| 6| 4| 2| 3| 2| 8| 3| 3| 3| |
| 9| 2| 3| 4| 8| 7| 7| 7| 6| 6| 0| 6| 9| 9| 6| 5| 8| 9| 6| 6| 0| 9| 3| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X| 6 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 | 4 2.3|
Basophilic Focus | X X X X X X X X X X| 27 |
Clear Cell Focus | X X | 7 |
Congestion | 3 | 2 2.5|
Degeneration, Cystic | | 5 1.4|
Eosinophilic Focus | X X X X | 9 |
Granuloma | 1 1 1 1 1 3 | 10 1.5|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hepatodiaphragmatic Nodule | X | 2 |
Hyperplasia, Focal | 2 | 5 2.4|
Inflammation, Chronic | 1 1 1 1 1| 8 1.3|
Mixed Cell Focus | | 3 |
Bile Duct, Hyperplasia | 1 2 3 3 2 3 3 1 3 2 2 2 1 2 1 2 1 3 3 2 1| 45 2.2|
Centrilobular, Necrosis | 3 3 4 1 4 | 6 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 4 | 2 3.0|
Kupffer Cell, Hyperplasia | 3 | 1 3.0|
Kupffer Cell, Pigmentation | 3 | 1 3.0|
Lobules, Necrosis | | 4 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 11 |
Accessory Spleen | X | 1 |
Fat, Necrosis | 3 4| 5 3.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 1 1 3 3 1 1 1 3 2| 17 1.7|
Cytoplasmic Alteration | 3 | 3 3.0|
Hyperplasia, Focal | 2 2 3 2 3 2 1 3 3| 17 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 2| 7| 1| 3| 7| 3| 7| 8| 3| 3| 7| 2| 4| 0| 3| 3| 6| 4| 2| 3| 2| 8| 3| 3| 3| |
| 9| 2| 3| 4| 8| 7| 7| 7| 6| 6| 0| 6| 9| 9| 6| 5| 8| 9| 6| 6| 0| 9| 3| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 2 2.5|
Inflammation, Chronic | 3 | 1 3.0|
Mineralization | | 1 1.0|
Ulcer | 4 1 4 | 4 2.5|
Mucosa, Hyperplasia | 3 3 4 | 7 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Erosion | | 1 3.0|
Inflammation, Chronic Active | 3 3 | 2 3.0|
Mineralization | 2 | 3 1.3|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + + | 2 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + +| 4 |
Polyarteritis | 2 3 3 2| 4 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 1 3 2 2 1 3 2 2 2 1 2 3 2 3 1 2 3| 37 2.0|
Myocardium, Inflammation, Chronic | 3 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X | 11 |
Angiectasis | | 2 2.5|
Clear Cell Focus | X X X X | 5 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Focal | 1 2 2 2| 10 1.7|
Necrosis | 3 4 | 2 3.5|
Vacuolization Cytoplasmic, Diffuse | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Cyst | | 1 |
Hyperplasia | 1 1 2 1 1 3 1 2 2 1 1 2 1| 26 1.5|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 2| 7| 1| 3| 7| 3| 7| 8| 3| 3| 7| 2| 4| 0| 3| 3| 6| 4| 2| 3| 2| 8| 3| 3| 3| |
| 9| 2| 3| 4| 8| 7| 7| 7| 6| 6| 0| 6| 9| 9| 6| 5| 8| 9| 6| 6| 0| 9| 3| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 4 1 | 7 1.6|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 2 3 1 1| 9 1.6|
Pars Distalis, Necrosis | 4 | 1 4.0|
Pars Intermedia, Angiectasis | 3 | 1 3.0|
Pars Nervosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X X | 3 |
C-Cell, Hyperplasia | 2 1 1 3 2| 12 1.5|
Follicle, Cyst | X X X X| 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Ectasia | | 1 2.0|
Inflammation, Chronic | 2 2 3 2 2 2 3 2 2 | 23 2.4|
Inflammation, Suppurative | 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Inflammation, Chronic | 1 1| 2 1.0|
Inflammation, Suppurative | 1 2 1 1 2 2 2 2 3 3 3 1 1 | 26 1.9|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 1 3 1 1 1 1 2 2 3| 21 1.8|
Interstitial Cell, Hyperplasia | 3 | 2 2.0|
Seminiferous Tubule, Atrophy | 4 4 | 4 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 2 3 | 3 2.7|
Hyperplasia, Reticulum Cell | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 2| 7| 1| 3| 7| 3| 7| 8| 3| 3| 7| 2| 4| 0| 3| 3| 6| 4| 2| 3| 2| 8| 3| 3| 3| |
| 9| 2| 3| 4| 8| 7| 7| 7| 6| 6| 0| 6| 9| 9| 6| 5| 8| 9| 6| 6| 0| 9| 3| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hypocellularity | 3 | 1 3.0|
Myelofibrosis | 4 | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Inguinal, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Hemorrhage | 2 4 2 | 6 2.7|
Mediastinal, Hyperplasia, Plasma Cell| 2 2 3 | 5 2.4|
Mediastinal, Pigmentation | 3 3 2 | 8 2.9|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 3 3 3| 4 3.0|
Hyperplasia, Plasma Cell | 2 3 4 2 2 3 2 3 3 3 2| 18 2.7|
Lymphatic, Dilatation | 2 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erythrophagocytosis | 2 | 2 2.5|
Hemorrhage | 4 | 1 4.0|
Lymphatic, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 1| 2 2.0|
Hematopoietic Cell Proliferation | 3 4 3 2 2 | 6 2.8|
Hyperplasia, Re Cell | 3 3 | 2 3.0|
Necrosis | 4 | 1 4.0|
Pigmentation, Hemosiderin | 4 3 2 2 | 7 2.6|
Lymphoid Follicle, Atrophy | 3 | 1 3.0|
Red Pulp, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + M + + + + + + + M + + + + + + + +| 47 |
Cyst | X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Cystic | 3 2 2 4 1 2 1| 13 1.8|
Hyperplasia, Lobular | 1 | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst Epithelial Inclusion | X | 1 |
Hyperplasia, Basal Cell | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Osteopetrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 2| 7| 1| 3| 7| 3| 7| 8| 3| 3| 7| 2| 4| 0| 3| 3| 6| 4| 2| 3| 2| 8| 3| 3| 3| |
| 9| 2| 3| 4| 8| 7| 7| 7| 6| 6| 0| 6| 9| 9| 6| 5| 8| 9| 6| 6| 0| 9| 3| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X | 4 |
Congestion | | 1 2.0|
Hemorrhage | 2 | 2 2.5|
Hydrocephalus | 2 2 2 2 | 4 2.0|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 3 2.3|
Edema | | 2 2.5|
Foreign Body | 3 2 | 3 2.7|
Hemorrhage | 2 | 3 1.7|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 2 1 1 3 3 1 1 1 1 1 | 30 1.3|
Inflammation, Chronic | 1 1 1 1 1 4 1 1 | 14 1.3|
Inflammation, Suppurative | 3 3 | 2 3.0|
Leukocytosis | 3 3 3 | 4 2.8|
Alveolar Epithelium, Hyperplasia | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X X X X X| 17 |
Foreign Body | 2 2 | 6 2.5|
Fungus | X X X X X X X X X| 15 |
Inflammation, Chronic | 2 3 2 | 7 2.7|
Pigmentation | | 1 1.0|
Mucosa, Hyperplasia | 2 2 3 2 | 7 2.6|
Mucosa, Metaplasia, Squamous | 3 2 3 3| 8 2.9|
Nerve, Hypertrophy | 4 | 1 4.0|
Olfactory Epithelium, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mucosa, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
Cataract | 2 3 2 | 6 2.7|
Cornea, Hyperplasia | | 1 1.0|
Retina, Atrophy | 4 4 3 | 6 3.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05037-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTACHLOROANISOLE Date: 06/23/97
Route: GAVAGE Time: 12:05:45
__________________________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 4| 5| 6| 7| 7| 5| 6| 6| 7| 7| 5| 5| 6| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 2| 7| 1| 3| 7| 3| 7| 8| 3| 3| 7| 2| 4| 0| 3| 3| 6| 4| 2| 3| 2| 8| 3| 3| 3| |
| 9| 2| 3| 4| 8| 7| 7| 7| 6| 6| 0| 6| 9| 9| 6| 5| 8| 9| 6| 6| 0| 9| 3| 3| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Sclera, Mineralization | 1 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Inflammation, Chronic | 2 3 3 2 2 2 4 3 2 3 3 3 3 2 3 1 2| 35 2.5|
Inflammation, Suppurative | 3 1 1 1 1 2| 15 1.6|
Mineralization | 1 1 1 1 1 3 1 1 | 13 1.2|
Nephropathy | 2 3 1 1 3 1 2 2 2 3 2 4 3 3 3 1 1 3 4 3 1 2 3 1 3| 49 2.4|
Renal Tubule, Pigmentation | 1 1 2 2 1 2 1 1 2 2 2 1 1| 23 1.3|
Transitional Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
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