TDMS Study 05037-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst PENTACHLOROANISOLE DATE: 06/23/97
EXPERIMENT: 05037 TEST: 03 TIME: 09:58:36
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NOI-ES-28024 ROUTE: GAVAGE NTP C#: 56520
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 1825-21-4
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL
INCLUDE 004 VEHICLE CONTROL
INCLUDE 007 40 MG/KG
INCLUDE 010 40 MG/KG
INCLUDE 013 20 MG/KG
INCLUDE 016 20 MG/KG
INCLUDE 019 10 MG/KG
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst PENTACHLOROANISOLE DATE: 06/23/97
EXPERIMENT: 05037 TEST: 03 TIME: 09:58:36
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NOI-ES-28024 ROUTE: GAVAGE NTP C#: 56520
PATHOLOGIST: J. HEATH S. EUSTIS CAS: 1825-21-4
PENTACHLOROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 213 507 527 568 594 605 611 617 624 649 |
| 651 653 683 683 684 689 701 702 703 703 |
| 704 705 705 705 718 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 4 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 435 437 488 520 521 529 535 568 570 577 |
| 578 598 604 613 626 627 634 649 649 667 |
| 684 687 689 709 724 726 |
| CENSORED DEATHS |
| 572 625 640 678 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 20 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 5 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 486 493 507 509 568 578 628 633 654 683 |
| 684 687 697 701 703 704 704 705 718 718 |
| 719 |
| CENSORED DEATHS |
| 185 185 185 185 185 |
| |
==================================================================================
PENTACHLOROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 40 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 32 CENSORED DEATHS 4 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 60 66 66 66 67 67 96 96 96 96 |
| 96 97 97 108 108 108 109 109 109 110 |
| 206 206 488 514 548 635 636 684 697 697 |
| 702 709 |
| CENSORED DEATHS |
| 185 185 592 696 |
| |
==================================================================================
PENTACHLOROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 98.0 98.0 98.0 98.0 94.0 88.0 76.0 48.0 |
|CONTROL | |
| | |
|10 MG/KG | 100.0 100.0 100.0 100.0 100.0 96.0 86.0 73.8 61.1 45.3 |
| | |
| | |
|20 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 91.1 86.7 80.0 53.3 |
| | |
| | |
|40 MG/KG | 88.0 60.0 55.7 55.7 55.7 55.7 51.4 49.3 44.8 33.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 10 MG/KG 20 MG/KG 40 MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 48.0% 45.3% 53.3% 33.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.006 P=0.549 P=0.709N P=0.009 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 639.6 601.7 641.9 267.2 |
|NATURAL DEATHS (C) | (20.6) (16.1) (18.1) (45.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 682.5 654.8 638.0 408.3 |
|(STANDARD ERROR) | (12.4) (12.1) (23.6) (42.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PENTACHLOROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 213 353 444 477 522 526 579 579 589 590 |
| 596 616 620 640 669 683 684 687 705 705 |
| 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 20 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 330 345 541 589 611 625 647 667 673 687 |
| 689 695 702 718 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 40 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 517 570 628 712 715 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PENTACHLOROANISOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 98.0 96.0 96.0 92.0 88.0 78.0 72.0 58.0 |
|CONTROL | |
| | |
|20 MG/KG | 100.0 100.0 100.0 96.0 96.0 96.0 94.0 92.0 86.0 70.0 |
| | |
| | |
|40 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 96.0 94.0 88.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 20 MG/KG 40 MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 58.0% 70.0% 88.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.219N P=0.001N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 580.7 616.2 644.2 |
|NATURAL DEATHS (C) | (27.6) (32.0) (35.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 666.7 695.2 718.8 |
|(STANDARD ERROR) | (15.5) (11.9) ( 5.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PENTACHLOROANISOLE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
10 MG/KG = 2
20 MG/KG = 3
40 MG/KG = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 2 3
| 44 1 33 1
| 2 23 1 21 1
| 1 1
90 + 3 22 33 1 1
| 4 4 22 3 11 3
P | 2 2 1113
E | 22 13 13
R 80 + 3 3
C | 2 2 11
E | 4 4 222 1 13
N | 2 2 33
T 70 + 1133
| 22 1 1
S | 2 2
U |
R 60 + 4 4 2 2 2 3 3
V | 22
I | 4 4
V | 4 4 4 2 121 3
A 50 + 4 4 211
L | 1 1
| 4 4 2 2
| 4 4
40 +
| 44
| 44
| 4 4
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.
PENTACHLOROANISOLE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
20 MG/KG = 2
40 MG/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
|
| 1 2 21 3 3
| 21 1 2 3 3
95 +
| 1 1 2 2 3 3
| 1 1 2 2 33
|
90 + 11 2 2 33
|
P | 1 1 2 2 3 3
E | 2 2
R 85 +
C | 1 1 22
E | 2 2
N |
T 80 + 11
|
S | 1 1 22
U | 11 22
R 75 +
V | 1 1 2 2
I | 1 1 22
V |
A 70 + 1 1 2 2
L |
|
| 11
65 +
| 1 1
|
|
60 + 1 1
|
| 1 1
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 2 obs hidden.