TDMS Study 05040-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
HYDROQUINONE
NTP Experiment-Test: 05040-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 11:58:38
Facility: American Biogenics Corp.
Chemical CAS #: 000123319
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05040-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 11:58:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 65 65 65
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 7 11 6
Dead 11 5 9
Accident 4
Survivors
Terminal Sacrifice 37 39 36
Animals Examined Microscopically 55 55 55
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (50) (12) (48)
Inflammation, Chronic 1 (2%)
Mucosa, Hyperplasia, Focal 1 (2%)
Intestine Large, Cecum (52) (13) (53)
Colon, Serosa, Inflammation, Chronic 1 (8%)
Intestine Small, Duodenum (52) (15) (51)
Muscularis, Inflammation, Acute 1 (7%)
Serosa, Ileum, Jejunum, Inflammation, Chronic 1 (7%)
Intestine Small, Ileum (49) (14) (52)
Amyloid Deposition 1 (2%) 1 (2%)
Intestine Small, Jejunum (52) (12) (52)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (55) (55) (55)
Amyloid Deposition 1 (2%)
Angiectasis 1 (2%) 2 (4%)
Basophilic Focus 2 (4%) 6 (11%) 3 (5%)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 3 (5%) 3 (5%) 2 (4%)
Fatty Change 4 (7%) 2 (4%)
Focal Cellular Change 1 (2%)
Hematopoietic Cell Proliferation 3 (5%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 5 (9%) 4 (7%) 5 (9%)
Inflammation, Focal, Granulomatous 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis 3 (5%) 2 (4%) 2 (4%)
Biliary Tract, Inflammation, Chronic 1 (2%)
Kupffer Cell, Hyperplasia 1 (2%)
Mesentery (19) (12) (4)
Inflammation, Chronic 2 (11%) 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05040-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 11:58:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Suppurative 1 (5%) 1 (8%)
Necrosis, Focal 1 (8%)
Fat, Hemorrhage, Focal 1 (5%)
Fat, Necrosis, Focal 11 (58%) 6 (50%) 2 (50%)
Fat, Lymphatic, Hemorrhage, Focal 1 (5%)
Perivascular, Inflammation, Chronic 1 (5%)
Pancreas (54) (16) (53)
Inflammation, Chronic 1 (2%) 3 (19%) 1 (2%)
Inflammation, Subacute 1 (2%)
Duct, Ectasia 1 (2%) 1 (6%)
Salivary Glands (54) (54) (54)
Inflammation, Chronic 25 (46%) 34 (63%) 33 (61%)
Stomach, Glandular (53) (16) (55)
Erosion, Focal 1 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (55) (17) (55)
Cardiomyopathy 1 (2%)
Hemorrhage 1 (6%)
Inflammation, Chronic 1 (2%) 1 (2%)
Atrioventricular Valve, Inflammation,
Subacute 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (6%)
Coronary Artery, Inflammation, Chronic 1 (6%) 1 (2%)
Epicardium, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (55) (13) (55)
Degeneration, Diffuse 1 (2%)
Degeneration, Focal 2 (4%)
Hematopoietic Cell Proliferation 4 (7%)
Hyperplasia, Focal 3 (5%) 2 (4%)
Adrenal Gland, Medulla (51) (11) (52)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (52) (29) (52)
Pars Distalis, Angiectasis 1 (2%) 2 (7%) 4 (8%)
Pars Distalis, Hyperplasia, Focal 13 (25%) 4 (14%) 13 (25%)
Thyroid Gland (55) (55) (55)
Inflammation, Chronic 3 (5%) 4 (7%) 9 (16%)
Polyarteritis 1 (2%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 13 (24%) 47 (85%) 45 (82%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05040-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 11:58:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (55) (53) (54)
Angiectasis 1 (2%)
Cyst 12 (22%) 12 (23%) 14 (26%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Artery, Periovarian Tissue, Inflammation,
Chronic 1 (2%)
Periovarian Tissue, Inflammation, Chronic 5 (9%) 5 (9%) 4 (7%)
Periovarian Tissue, Inflammation, Subacute 1 (2%)
Periovarian Tissue, Necrosis 1 (2%)
Serosa, Hyperplasia, Papillary 1 (2%)
Uterus (54) (29) (55)
Hydrometra 2 (4%) 2 (4%)
Inflammation, Chronic 1 (3%)
Endometrium, Hemorrhage 1 (2%)
Endometrium, Hyperplasia, Cystic 37 (69%) 18 (62%) 31 (56%)
Endometrium, Inflammation, Suppurative 2 (4%)
Myometrium, Hyperplasia 1 (2%)
Submucosa, Angiectasis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (55) (16) (54)
Hyperplasia 1 (2%)
Lymph Node (55) (22) (54)
Hyperplasia, Plasma Cell 1 (5%) 1 (2%)
Axillary, Hyperplasia, Lymphoid 1 (2%)
Axillary, Hyperplasia, Plasma Cell 1 (5%) 1 (2%)
Deep Cervical, Hyperplasia, Plasma Cell 1 (2%)
Iliac, Hematopoietic Cell Proliferation 1 (5%)
Inguinal, Hematopoietic Cell Proliferation 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 2 (9%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Mediastinal, Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05040-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 11:58:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Renal, Hemorrhage 1 (5%)
Lymph Node, Mandibular (50) (16) (49)
Hyperplasia, Lymphoid 2 (4%) 1 (6%) 1 (2%)
Hyperplasia, Lymphoid, Plasma Cell 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (52) (17) (52)
Congestion 1 (2%) 2 (4%)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (6%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 2 (12%) 2 (4%)
Hyperplasia, Lymphoid, Plasma Cell 1 (2%)
Thrombosis 1 (2%)
Spleen (55) (22) (55)
Amyloid Deposition 1 (2%)
Fibrosis 1 (5%)
Hematopoietic Cell Proliferation 7 (13%) 2 (9%) 4 (7%)
Hyperplasia, Lymphoid 1 (5%) 1 (2%)
Pigmentation, Hemosiderin 1 (5%)
Thymus (44) (13) (47)
Ectopic Parathyroid Gland 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (52) (20) (53)
Hyperplasia 9 (17%) 1 (5%) 5 (9%)
Hyperplasia, Cystic 1 (2%)
Inflammation, Chronic 1 (2%)
Duct, Ectasia 1 (2%)
Skin (55) (16) (55)
Ulcer 2 (4%) 4 (7%)
Abdominal, Subcutaneous Tissue, Abscess 1 (6%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (55) (16) (55)
Fibrous Osteodystrophy 5 (9%) 3 (5%)
Joint, Tarsal, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05040-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 11:58:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (55) (16) (55)
Atrophy 1 (2%)
Hemorrhage, Focal 1 (2%)
Mineralization 5 (9%) 3 (5%)
Cerebrum, Hemorrhage 1 (6%)
Cerebrum, Inflammation, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (55) (55) (55)
Atelectasis 1 (2%)
Congestion 1 (2%) 3 (5%)
Hemorrhage, Focal 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 5 (9%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Alveolus, Hyperplasia, Macrophage 1 (2%) 2 (4%)
Artery, Hypertrophy 1 (2%)
Artery, Capillary, Vein, Leukocytosis 1 (2%)
Peribronchiolar, Inflammation, Chronic 1 (2%)
Perivascular, Inflammation, Chronic 2 (4%) 2 (4%)
Nose (54) (16) (55)
Inflammation, Acute 1 (2%)
Mucosa, Inflammation, Chronic 1 (2%)
Nasolacrimal Duct, Foreign Body 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 1 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (5)
Conjunctiva, Retrobulbar, Inflammation 1 (20%)
Lacrimal Gland (2)
Inflammation, Chronic 1 (50%)
Extraorbital, Inflammation, Chronic 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (55) (16) (55)
Amyloid Deposition 2 (4%) 2 (4%)
Glomerulosclerosis 1 (2%)
Inflammation, Chronic 35 (64%) 8 (50%) 34 (62%)
Metaplasia, Focal, Osseous 1 (2%)
Nephropathy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05040-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 11:58:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Cortex, Fibrosis, Focal 1 (2%)
Cortex, Metaplasia, Osseous 1 (2%)
Cortex, Necrosis, Focal 1 (2%)
Renal Tubule, Pigmentation, Hemosiderin 1 (2%)
Urinary Bladder (53) (15) (54)
Cytomegaly 1 (2%)
Muscularis, Submucosa, Inflammation 1 (2%)
Submucosa, Inflammation, Chronic 28 (53%) 4 (27%) 33 (61%)
Submucosa, Inflammation, Chronic, Hemorrhagic 1 (2%)
Subserosa, Inflammation, Chronic 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05040-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 11:58:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 65 65 65
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 12 10 5
Dead 10 7 14
Survivors
Terminal Sacrifice 33 37 36
Wrong Sex 1
Animals Examined Microscopically 55 54 55
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (44) (11) (48)
Inflammation, Chronic 1 (2%)
Intestine Small, Ileum (48) (10) (47)
Amyloid Deposition 1 (2%)
Mucosa, Necrosis 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Jejunum (50) (13) (45)
Diverticulum 1 (8%)
Hyperplasia, Lymphoid 1 (2%)
Mucosa, Inflammation, Suppurative 1 (8%)
Liver (55) (54) (55)
Amyloid Deposition 1 (2%)
Anisokaryosis 2 (4%) 12 (22%)
Autolysis 1 (2%)
Basophilic Focus 2 (4%) 5 (9%) 11 (20%)
Clear Cell Focus 2 (4%)
Cyst 1 (2%) 1 (2%) 1 (2%)
Cytomegaly 3 (5%)
Eosinophilic Focus 2 (4%) 3 (6%) 4 (7%)
Fatty Change 3 (5%)
Focal Cellular Change 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Re Cell 1 (2%)
Infarct 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Mixed Cell Focus 2 (4%) 1 (2%)
Necrosis 4 (7%) 2 (4%) 2 (4%)
Necrosis, Focal 1 (2%)
Syncytial Alteration 5 (9%) 3 (6%) 25 (45%)
Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05040-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 11:58:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Degeneration, Ballooning 1 (2%)
Sinusoid, Dilatation, Focal 1 (2%)
Mesentery (6) (4) (5)
Hemorrhage 1 (17%)
Inflammation, Acute 1 (17%) 1 (20%)
Inflammation, Chronic 1 (25%) 1 (20%)
Inflammation, Suppurative 1 (25%)
Fat, Inflammation, Chronic 1 (20%)
Fat, Necrosis, Focal 3 (50%) 1 (20%)
Pancreas (54) (15) (53)
Fibrosis, Focal 1 (2%)
Hemorrhage, Focal 1 (2%)
Inflammation, Chronic 2 (4%)
Acinus, Vacuolization Cytoplasmic 1 (2%)
Serosa, Inflammation, Acute 1 (2%)
Salivary Glands (55) (16) (55)
Concretion, Chronic 1 (2%)
Degeneration, Chronic 1 (2%)
Inflammation, Chronic 30 (55%) 8 (50%) 31 (56%)
Stomach, Forestomach (55) (15) (53)
Acanthosis 1 (2%)
Ulcer 1 (2%)
Stomach, Glandular (55) (15) (55)
Ulcer 1 (2%) 1 (2%)
Tooth (6) (1) (2)
Peridontal Tissue, Inflammation, Suppurative 2 (33%) 1 (50%)
Peridontal Tissue, Pulp, Abscess 1 (17%)
Pulp, Abscess 2 (33%) 1 (50%)
Pulp, Necrosis 1 (17%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (55) (17) (55)
Cardiomyopathy 1 (2%)
Inflammation, Acute 1 (2%) 1 (6%)
Inflammation, Chronic 1 (2%)
Atrium Left, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (55) (53) (54)
Subcapsular, Hyperplasia 1 (2%)
Adrenal Gland, Cortex (55) (52) (54)
Degeneration, Focal 5 (9%) 1 (2%)
Ectopic Tissue 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05040-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 11:58:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia, Focal 9 (16%) 2 (4%) 6 (11%)
Hypertrophy, Focal 1 (2%) 1 (2%)
Spindle Cell, Subcapsular, Proliferation 1 (2%)
Adrenal Gland, Medulla (54) (52) (54)
Hyperplasia, Focal 1 (2%) 3 (6%) 1 (2%)
Pituitary Gland (50) (14) (50)
Pars Distalis, Hyperplasia, Focal 3 (6%) 1 (7%) 5 (10%)
Thyroid Gland (55) (53) (54)
Inflammation, Chronic 1 (2%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Follicle, Cyst, Multiple 1 (2%)
Follicle, Inflammation, Acute 1 (2%)
Follicular Cell, Hyperplasia 5 (9%) 15 (28%) 19 (35%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (54) (17) (54)
Inflammation, Chronic 1 (2%) 3 (6%)
Preputial Gland (11) (9) (7)
Inflammation, Chronic 5 (45%) 3 (33%) 2 (29%)
Inflammation, Suppurative 5 (45%) 6 (67%) 4 (57%)
Duct, Ectasia 1 (9%) 1 (11%) 1 (14%)
Prostate (55) (17) (55)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 6 (11%) 1 (6%) 9 (16%)
Inflammation, Chronic Active 3 (5%)
Inflammation, Suppurative 1 (2%) 1 (6%)
Serosa, Inflammation, Acute 1 (2%)
Seminal Vesicle (55) (17) (55)
Dilatation 1 (2%)
Inflammation, Chronic 2 (4%)
Inflammation, Suppurative 1 (2%)
Serosa, Inflammation, Acute 1 (2%)
Testes (55) (18) (55)
Atrophy 2 (4%) 1 (2%)
Germinal Epithelium, Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05040-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 11:58:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (55) (29) (55)
Congestion 1 (3%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Lymphoid, Plasma Cell 1 (3%)
Hyperplasia, Plasma Cell 1 (2%) 1 (3%)
Inflammation, Acute 1 (2%)
Axillary, Hyperplasia, Lymphoid 1 (2%)
Axillary, Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Iliac, Hematopoietic Cell Proliferation 1 (3%)
Iliac, Hyperplasia 1 (3%)
Iliac, Hyperplasia, Lymphoid 1 (2%)
Iliac, Hyperplasia, Plasma Cell 1 (2%) 1 (3%)
Inguinal, Cyst 1 (2%)
Inguinal, Hyperplasia, Lymphoid 1 (3%)
Lumbar, Congestion 1 (2%)
Lumbar, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hyperplasia 1 (2%)
Pancreatic, Congestion 1 (2%)
Popliteal, Hyperplasia, Lymphoid 1 (2%)
Popliteal, Hyperplasia, Plasma Cell 1 (2%)
Renal, Hyperplasia, Lymphoid 1 (2%)
Renal, Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mandibular (52) (17) (51)
Congestion 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Plasma Cell 5 (10%)
Lymph Node, Mesenteric (54) (23) (50)
Congestion 11 (20%) 6 (26%) 10 (20%)
Hematopoietic Cell Proliferation 1 (2%) 1 (4%) 1 (2%)
Hyperplasia, Lymphoid 3 (6%)
Inflammation, Acute 1 (2%)
Spleen (55) (52) (54)
Amyloid Deposition 1 (2%)
Hematopoietic Cell Proliferation 10 (18%) 14 (27%) 6 (11%)
Hyperplasia, Lymphoid 2 (4%)
Thymus (39) (10) (42)
Amyloid Deposition 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (55) (33) (55)
Acanthosis 2 (4%) 3 (9%) 2 (4%)
Alopecia 1 (2%)
Atrophy 2 (4%) 3 (9%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (3%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05040-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 11:58:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Ulcer 5 (9%) 6 (18%) 14 (25%)
Artery, Subcutaneous Tissue, Inflammation,
Chronic 1 (2%)
Dermis, Fibrosis 1 (2%)
Dermis, Inflammation, Chronic 1 (2%) 1 (3%) 2 (4%)
Dermis, Dorsal, Atrophy 1 (2%)
Prepuce, Inflammation, Chronic 2 (4%)
Prepuce, Inflammation, Suppurative 1 (3%)
Subcutaneous Tissue, Edema 2 (4%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Subacute 1 (2%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (2%) 1 (3%)
Tail, Dermis, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (54) (32) (55)
Hyperostosis 5 (16%)
Joint, Tarsal, Hyperostosis 10 (19%) 10 (31%) 7 (13%)
Skeletal Muscle (3)
Abdominal, Fibrosis 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (55) (17) (55)
Cyst Epithelial Inclusion 1 (6%)
Mineralization 2 (4%) 3 (5%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (55) (31) (55)
Congestion 4 (13%)
Hemorrhage 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (3%) 1 (2%)
Alveolar Epithelium, Hyperplasia, Atypical 1 (3%)
Alveolus, Hyperplasia, Macrophage 1 (2%) 1 (3%) 2 (4%)
Vein, Leukocytosis 1 (3%)
Nose (55) (17) (55)
Lumen, Turbinate, Inflammation, Suppurative 2 (4%) 1 (2%)
Mucosa, Inflammation, Chronic 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 2 (4%) 3 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05040-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 11:58:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50 MG/KG 100MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Lacrimal Gland (1) (1)
Extraorbital, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (55) (17) (55)
Amyloid Deposition 1 (2%)
Calculus Micro Observation Only 2 (4%)
Cyst, Multiple 1 (2%)
Cytoplasmic Alteration 1 (6%)
Glomerulosclerosis 3 (5%) 1 (2%)
Inflammation, Chronic 45 (82%) 11 (65%) 44 (80%)
Inflammation, Suppurative 1 (2%) 1 (6%)
Nephropathy 1 (2%) 1 (6%) 1 (2%)
Cortex, Infarct 1 (2%)
Renal Tubule, Mineralization 2 (4%)
Urethra (3) (2)
Distal, Concretion 1 (50%)
Distal, Inflammation, Chronic 1 (33%)
Distal, Inflammation, Suppurative 1 (50%)
Proximal, Inflammation, Suppurative 2 (67%) 1 (50%)
Urinary Bladder (54) (15) (55)
Muscularis, Hemorrhage 1 (2%)
Perivascular, Inflammation, Chronic 2 (4%)
Submucosa, Inflammation, Chronic 15 (28%) 2 (13%) 13 (24%)
Wall, Inflammation, Subacute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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