TDMS Study 05040-02 Pathology Tables
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
Facility: American Biogenics Corp.
Chemical CAS #: 000123319
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|
| 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A A + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + A + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + A A + + + +|
Lymphoma Malignant Lymphocytic | X|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A A + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | X|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + + + +|
Lymphoma Malignant Lymphocytic | X|
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
Fat, Lymphoma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Glandular, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|
| 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
Epicardium, Lymphoma Malignant | |
Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Lymphoma Malignant | |
Lymphocytic | |
Capsule, Lymphoma Malignant | |
Capsule, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + + + + +|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + + + M + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + I + + + + + + +|
Pars Distalis, Adenoma | X X X |
Pars Distalis, Carcinoma | X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma, Poorly Differentiated | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|
| 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Teratoma | X |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | X X|
Periovarian Tissue, Lymphoma | |
Malignant | |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
Serosa, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Axillary, Lymphoma Malignant | X |
Bronchial, Lymphoma Malignant | |
Lymphocytic | X |
Bronchial, Lymphoma Malignant Mixed | |
Iliac, Lymphoma Malignant | X |
Iliac, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Inguinal, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | X X |
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X|
Mediastinal, Lymphoma Malignant | X |
Mediastinal, Lymphoma Malignant Mixed| X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X|
Pancreatic, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant | X |
Thoracic, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + M + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|
| 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X X X X|
Lymphoma Malignant | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X X X |
Lymphoma Malignant | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + M M + + + +|
Lymphoma Malignant Lymphocytic | X X X|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
Subcutaneous Tissue, Lymphoma | |
Malignant | X |
Tail, Neurofibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Extension, Metastatic, | |
Pituitary Gland | X |
Cerebrum, Oligodendroglioma Malignant| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Basal Cell Carcinoma, Metastatic | |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|
| 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant | X X |
Lymphoma Malignant Mixed | X |
Pleura, Lymphoma Malignant | |
Lymphocytic | X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Canal, External Ear, Squamous Cell | |
Carcinoma | |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X |
Capsule, Lymphoma Malignant | |
Lymphocytic | X|
Fat, Lymphoma Malignant Mixed | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X|
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
Lymphoma Malignant Lymphocytic | X X X X X X X X|
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|
| 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M + + + + + + + A + + + + A|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + A|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X|
Lymphoma Malignant Mixed | |
Fat, Lymphoma Malignant | X|
__________________________________________________________________________|
Pancreas | + + + + + + M + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Glandular, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|
| 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Epicardium, Lymphoma Malignant | |
Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
Capsule, Lymphoma Malignant | |
Lymphocytic | |
Capsule, Lymphoma Malignant | X|
Capsule, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + + + + + + M + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + M M + + M + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Carcinoma | |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma, Poorly Differentiated | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|
| 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Teratoma | |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | |
Periovarian Tissue, Lymphoma | |
Malignant | X|
Periovarian Tissue, Lymphoma | |
Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + M + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Serosa, Lymphoma Malignant | X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X|
Axillary, Lymphoma Malignant | |
Bronchial, Lymphoma Malignant | |
Lymphocytic | |
Bronchial, Lymphoma Malignant Mixed | X |
Iliac, Lymphoma Malignant | |
Iliac, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant Mixed| X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | |
Pancreatic, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant | |
Thoracic, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|
| 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | X|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | X|
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Thymus | + + + A M + M + + + + + + + + + + + + M|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
Subcutaneous Tissue, Lymphoma | |
Malignant | |
Tail, Neurofibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Extension, Metastatic, | |
Pituitary Gland | |
Cerebrum, Oligodendroglioma Malignant| |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X|
Alveolar/Bronchiolar Carcinoma | |
Basal Cell Carcinoma, Metastatic | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|
| 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant | X|
Lymphoma Malignant Mixed | |
Pleura, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Trachea | + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Canal, External Ear, Squamous Cell | |
Carcinoma | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X|
Lymphoma Malignant Mixed | |
Capsule, Lymphoma Malignant | |
Lymphocytic | |
Fat, Lymphoma Malignant Mixed | |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + M + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X|
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4| | |
DAY ON TEST | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5| | |
| 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + + + + | 50 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + | 52 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + M + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + | 52 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + | 52 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 55 |
Hemangioma | | 1 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | | 2 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | | 2 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Mesentery | + + + + + | 19 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Fat, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + | 54 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + M + + + + + + + + | 54 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4| | |
DAY ON TEST | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5| | |
| 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 54 |
Glandular, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 53 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant | | 1 |
Epicardium, Lymphoma Malignant | | |
Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + | 55 |
Capsule, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Capsule, Lymphoma Malignant | | 1 |
Capsule, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + M + + + | 51 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + M + + + + | 51 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + M + + + + M | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + I + + + + | 52 |
Pars Distalis, Adenoma | X X X X | 11 |
Pars Distalis, Carcinoma | | 1 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | | 1 |
Follicular Cell, Adenoma | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4| | |
DAY ON TEST | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5| | |
| 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Sarcoma, Poorly Differentiated | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Teratoma | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 3 |
Periovarian Tissue, Lymphoma | | |
Malignant | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + | 54 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X | 1 |
Serosa, Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant | | 1 |
Axillary, Lymphoma Malignant | | 1 |
Bronchial, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Bronchial, Lymphoma Malignant Mixed | | 1 |
Iliac, Lymphoma Malignant | | 1 |
Iliac, Lymphoma Malignant Mixed | X | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4| | |
DAY ON TEST | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5| | |
| 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Lymphoma Malignant | | 2 |
Lumbar, Lymphoma Malignant Mixed | X | 3 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 3 |
Mediastinal, Lymphoma Malignant | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant Mixed | X X | 4 |
Renal, Lymphoma Malignant Lymphocytic| X | 2 |
Renal, Lymphoma Malignant | | 1 |
Thoracic, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + | 50 |
Lymphoma Malignant Lymphocytic | X X | 6 |
Lymphoma Malignant | | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + | 52 |
Lymphoma Malignant Lymphocytic | X X X | 11 |
Lymphoma Malignant | | 3 |
Lymphoma Malignant Mixed | X X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Lymphocytic | X X | 10 |
Lymphoma Malignant | | 3 |
Lymphoma Malignant Mixed | X X | 7 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + M + + M M | 44 |
Lymphoma Malignant Lymphocytic | | 4 |
Lymphoma Malignant Mixed | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + + + + | 52 |
Adenocarcinoma | | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + | 55 |
Basal Cell Carcinoma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4| | |
DAY ON TEST | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5| | |
| 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Lymphoma | | |
Malignant | | 1 |
Tail, Neurofibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 55 |
Carcinoma, Extension, Metastatic, | | |
Pituitary Gland | | 1 |
Cerebrum, Oligodendroglioma Malignant| X | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + + + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 55 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Basal Cell Carcinoma, Metastatic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 4 |
Lymphoma Malignant | | 3 |
Lymphoma Malignant Mixed | X | 2 |
Pleura, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + | 54 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Canal, External Ear, Squamous Cell | | |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
Adenoma | | 2 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4| | |
DAY ON TEST | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5| | |
| 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X X | 4 |
Lymphoma Malignant | | 2 |
Lymphoma Malignant Mixed | X | 2 |
Capsule, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Fat, Lymphoma Malignant Mixed | X | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + | 53 |
Lymphoma Malignant Lymphocytic | X X | 4 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + | 55 |
Lymphoma Malignant | | 3 |
Lymphoma Malignant Lymphocytic | X X X | 14 |
Lymphoma Malignant Mixed | X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|
| 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Gallbladder | + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + |
__________________________________________________________________________|
Intestine Small | + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
Serosa, Fibrosarcoma, Metastatic, | |
Mesentery | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
Lymphoma Malignant Lymphocytic | |
Jejunum, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Cholangiocarcinoma, Metastatic | |
Hemangioma | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + + + + |
Cholangiocarcinoma, Metastatic | |
Fibrosarcoma | X |
Fibrosarcoma, Multiple | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Pancreas | + + + + + |
Fibrosarcoma, Early Invasion, | |
Metastatic, Mesentery | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach | + + + + |
Serosa, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|
| 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
Capsule, Cholangiocarcinoma, | |
Metastatic | |
Capsule, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Carcinoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + |
Adenoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + |
Hemangioma | X |
Lymphoma Malignant Lymphocytic | |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|
| 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Bronchial, Lymphoma Malignant | |
Lymphocytic | |
Bronchial, Lymphoma Malignant Mixed | X |
Deep Cervical, Lymphoma Malignant | |
Mixed | |
Iliac, Lymphoma Malignant Lymphocytic| |
Iliac, Lymphoma Malignant | |
Iliac, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Lumbar, Lymphoma Malignant Mixed | X |
Lumbar, Osteosarcoma, Metastatic, | |
Bone | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant Mixed| X |
Popliteal, Lymphoma Malignant | |
Lymphocytic | |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
Renal, Cholangiocarcinoma, Metastatic| |
__________________________________________________________________________|
Spleen | + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
Capsule, Cholangiocarcinoma, | |
Metastatic | |
__________________________________________________________________________|
Thymus | + M + + M |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|
| 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
Adenocarcinoma | X X X |
Cholangiocarcinoma, Multiple, | |
Metastatic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Thoracic, Hepatocellular Carcinoma, | |
Metastatic, Liver | |
__________________________________________________________________________|
Skin | + + + + |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Hepatocellular | |
Carcinoma, Metastatic, Liver | |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
Lumbar, Vertebra, Osteosarcoma | X |
Vertebra, Cholangiocarcinoma, | |
Metastatic | |
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Fibrosarcoma, Early | |
Invasion, Metastatic, Mesentery | X |
Abdominal, Diaphragm, | |
Cholangiocarcinoma, Metastatic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Carcinoma, Extension, Metastatic, | |
Pituitary Gland | X |
Lymphoma Malignant Lymphocytic | |
Perivascular, Lymphoma Malignant | |
Lymphocytic | |
Perivascular, Lymphoma Malignant | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|
| 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant | |
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Nose | + + + + |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + |
Hepatocellular Carcinoma, Metastatic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
Osteosarcoma, Metastatic, Bone | X |
Capsule, Cholangiocarcinoma, | |
Metastatic | |
__________________________________________________________________________|
Urinary Bladder | + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | + A + M + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + M + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + |
Serosa, Fibrosarcoma, Metastatic, | |
Mesentery | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
Lymphoma Malignant Lymphocytic | X X |
Jejunum, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma, Metastatic | X |
Hemangioma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + + + + + |
Cholangiocarcinoma, Metastatic | X |
Fibrosarcoma | |
Fibrosarcoma, Multiple | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + |
Fibrosarcoma, Early Invasion, | |
Metastatic, Mesentery | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach | + + + + + + + |
Serosa, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + M |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + M + M |
Capsule, Cholangiocarcinoma, | |
Metastatic | X |
Capsule, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + |
__________________________________________________________________________|
Pituitary Gland | + + + + M + M + + + M +|
Pars Distalis, Adenoma | X X X X X|
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Follicular Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + |
Hemangioma | |
Lymphoma Malignant Lymphocytic | |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Bronchial, Lymphoma Malignant | |
Lymphocytic | |
Bronchial, Lymphoma Malignant Mixed | |
Deep Cervical, Lymphoma Malignant | |
Mixed | X |
Iliac, Lymphoma Malignant Lymphocytic| |
Iliac, Lymphoma Malignant | |
Iliac, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X X |
Lumbar, Lymphoma Malignant | |
Lumbar, Lymphoma Malignant Mixed | X |
Lumbar, Osteosarcoma, Metastatic, | |
Bone | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant Mixed| X |
Popliteal, Lymphoma Malignant | |
Lymphocytic | |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X |
Renal, Cholangiocarcinoma, Metastatic| X |
__________________________________________________________________________|
Spleen | + + + M + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X X X X X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X |
Capsule, Cholangiocarcinoma, | |
Metastatic | X |
__________________________________________________________________________|
Thymus | + + + + + + + |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + +|
Adenocarcinoma | X X|
Cholangiocarcinoma, Multiple, | |
Metastatic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Thoracic, Hepatocellular Carcinoma, | |
Metastatic, Liver | X |
__________________________________________________________________________|
Skin | + + + + + + + |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hepatocellular | |
Carcinoma, Metastatic, Liver | X |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
Lumbar, Vertebra, Osteosarcoma | |
Vertebra, Cholangiocarcinoma, | |
Metastatic | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Fibrosarcoma, Early | |
Invasion, Metastatic, Mesentery | |
Abdominal, Diaphragm, | |
Cholangiocarcinoma, Metastatic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Carcinoma, Extension, Metastatic, | |
Pituitary Gland | |
Lymphoma Malignant Lymphocytic | X |
Perivascular, Lymphoma Malignant | |
Lymphocytic | |
Perivascular, Lymphoma Malignant | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant | |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Hepatocellular Carcinoma, Metastatic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Bone | |
Capsule, Cholangiocarcinoma, | |
Metastatic | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X X X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4| | |
| 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 16 |
__________________________________________________________________________|____________|
Gallbladder | + + A M + | 12 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 14 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 15 |
Serosa, Fibrosarcoma, Metastatic, | | |
Mesentery | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + | 14 |
Lymphoma Malignant Lymphocytic | | 2 |
Jejunum, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + | 12 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 55 |
Cholangiocarcinoma, Metastatic | | 1 |
Hemangioma | | 1 |
Hepatocellular Carcinoma | | 2 |
Hepatocellular Adenoma | X | 11 |
Hepatocellular Adenoma, Multiple | X | 4 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Mesentery | + + + | 12 |
Cholangiocarcinoma, Metastatic | | 1 |
Fibrosarcoma | | 1 |
Fibrosarcoma, Multiple | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + A + + | 16 |
Fibrosarcoma, Early Invasion, | | |
Metastatic, Mesentery | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + M | 54 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4| | |
| 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + A + + + + | 17 |
Serosa, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 17 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 17 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + M + | 13 |
Capsule, Cholangiocarcinoma, | | |
Metastatic | | 1 |
Capsule, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 13 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M M | 11 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 13 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M | 29 |
Pars Distalis, Adenoma | | 14 |
Pars Distalis, Carcinoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + | 55 |
Lymphoma Malignant | X | 1 |
Follicular Cell, Adenoma | X | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | |
__________________________________________________________________________|____________|
Ovary | + + + + + M + M + + + + + | 53 |
Adenoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4| | |
| 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Lymphoma Malignant | X | 1 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + | 29 |
Hemangioma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 16 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 22 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Bronchial, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Bronchial, Lymphoma Malignant Mixed | | 1 |
Deep Cervical, Lymphoma Malignant | | |
Mixed | | 1 |
Iliac, Lymphoma Malignant Lymphocytic| X | 1 |
Iliac, Lymphoma Malignant | X | 1 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 3 |
Lumbar, Lymphoma Malignant | X | 1 |
Lumbar, Lymphoma Malignant Mixed | | 2 |
Lumbar, Osteosarcoma, Metastatic, | | |
Bone | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Mediastinal, Lymphoma Malignant | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Popliteal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 16 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4| | |
| 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + | 17 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | | 3 |
Renal, Cholangiocarcinoma, Metastatic| | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 22 |
Lymphoma Malignant Lymphocytic | X | 7 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | X | 4 |
Capsule, Cholangiocarcinoma, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + M + | 13 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 20 |
Adenocarcinoma | | 5 |
Cholangiocarcinoma, Multiple, | | |
Metastatic | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant | X | 1 |
Thoracic, Hepatocellular Carcinoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + | 16 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Hepatocellular | | |
Carcinoma, Metastatic, Liver | | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 16 |
Lumbar, Vertebra, Osteosarcoma | | 1 |
Vertebra, Cholangiocarcinoma, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Abdominal, Fibrosarcoma, Early | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4| | |
| 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Invasion, Metastatic, Mesentery | | 1 |
Abdominal, Diaphragm, | | |
Cholangiocarcinoma, Metastatic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 16 |
Carcinoma, Extension, Metastatic, | | |
Pituitary Gland | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Perivascular, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Perivascular, Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 55 |
Alveolar/Bronchiolar Adenoma | X | 6 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant | X | 1 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + | 16 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 16 |
Hepatocellular Carcinoma, Metastatic | | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Osteosarcoma, Metastatic, Bone | | 1 |
Capsule, Cholangiocarcinoma, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4| | |
| 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + | 55 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 7 |
Lymphoma Malignant Mixed | X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|
| 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + A + M + + A + + + + M + + + M + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small | + + + A + + + + A + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + A + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + A + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + A + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + A + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|
| 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Pericardium, Lymphoma Malignant | |
Undifferentiated Cell Type | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + + M + + + M + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Follicular Cell, Adenoma | X X X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + A + + + + + + + + + + + + + + + + + |
Cystadenoma | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | |
Periovarian Tissue, Lymphoma | |
Malignant | X |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | |
Periovarian Tissue, Lymphoma | |
Malignant Undifferentiated Cell | |
Type | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + M + + |
Lymphoma Malignant | X |
Axillary, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|
| 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Histiocytic | X |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Axillary, Lymphoma Malignant | X X X |
Iliac, Lymphoma Malignant | X X |
Iliac, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Inguinal, Lymphoma Malignant | X |
Lumbar, Lymphoma Malignant | |
Histiocytic | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | X X |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | X |
Pancreatic, Histiocytic Sarcoma | X |
Pancreatic, Lymphoma Malignant | |
Histiocytic | X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Pancreatic, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant Mixed | |
Popliteal, Lymphoma Malignant | X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + M + + |
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + M + + |
Histiocytic Sarcoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | X X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|
| 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | X X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + + + + M + A + + + M + + + + A M + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + + + + + + |
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Lymphoma | |
Malignant | X |
Thoracic, Subcutaneous Tissue, | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | X X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|
| 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Cell Type | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | X X X |
Lymphoma Malignant Mixed | |
Capsule, Lymphoma Malignant | |
Lymphocytic | |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|
| 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M M M M + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|
| 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Pericardium, Lymphoma Malignant | |
Undifferentiated Cell Type | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M M M + + + + + + + + + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + M + + + + + + + + |
Pars Distalis, Adenoma | X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Follicular Cell, Adenoma | X X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + |
Cystadenoma | |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | X |
Periovarian Tissue, Lymphoma | |
Malignant | |
Periovarian Tissue, Lymphoma | |
Malignant Mixed | X |
Periovarian Tissue, Lymphoma | |
Malignant Undifferentiated Cell | |
Type | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant | |
Axillary, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|
| 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Histiocytic | |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Axillary, Lymphoma Malignant | |
Iliac, Lymphoma Malignant | |
Iliac, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Inguinal, Lymphoma Malignant | |
Lumbar, Lymphoma Malignant | |
Histiocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Histiocytic Sarcoma | |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Pancreatic, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant Mixed | X |
Popliteal, Lymphoma Malignant | |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + M + + + + + + + M + + + + + + + |
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + |
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|
| 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + M |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + |
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Lymphoma | |
Malignant | |
Thoracic, Subcutaneous Tissue, | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|
| 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Cell Type | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + + + + |
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X X |
Capsule, Lymphoma Malignant | |
Lymphocytic | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8| | |
| 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + | 53 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + | 51 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + | 52 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + | 52 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 55 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Adenoma | X X | 11 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant | | 3 |
Lymphoma Malignant Mixed | X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 53 |
Lymphoma Malignant Lymphocytic | X X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 54 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8| | |
| 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 55 |
Pericardium, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 55 |
Lymphoma Malignant | | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + M + + | 52 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + M + + + | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + | 52 |
Pars Distalis, Adenoma | X X | 11 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 55 |
Follicular Cell, Adenoma | X | 6 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + | 54 |
Cystadenoma | X | 1 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | X X | 3 |
Periovarian Tissue, Lymphoma | | |
Malignant | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8| | |
| 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Periovarian Tissue, Lymphoma | | |
Malignant Undifferentiated Cell | | |
Type | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 54 |
Lymphoma Malignant | | 1 |
Axillary, Lymphoma Malignant | | |
Histiocytic | | 1 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Axillary, Lymphoma Malignant | | 3 |
Iliac, Lymphoma Malignant | | 2 |
Iliac, Lymphoma Malignant Mixed | X | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Inguinal, Lymphoma Malignant | | 1 |
Lumbar, Lymphoma Malignant | | |
Histiocytic | | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Lymphoma Malignant | | 2 |
Lumbar, Lymphoma Malignant Mixed | X | 2 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | X X | 2 |
Mediastinal, Lymphoma Malignant | | 1 |
Pancreatic, Histiocytic Sarcoma | | 1 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | X | 3 |
Pancreatic, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
Popliteal, Lymphoma Malignant | | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + | 49 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8| | |
| 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 6 |
Lymphoma Malignant | | 2 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + | 52 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 7 |
Lymphoma Malignant | | 3 |
Lymphoma Malignant Mixed | X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 55 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 7 |
Lymphoma Malignant | | 3 |
Lymphoma Malignant Mixed | X | 4 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M | 47 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 4 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 53 |
Adenocarcinoma | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 55 |
Subcutaneous Tissue, Lymphoma | | |
Malignant | | 1 |
Thoracic, Subcutaneous Tissue, | | |
Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8| | |
| 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 55 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 55 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Carcinoma, Metastatic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant | | 3 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
__________________________________________________________________________|____________|
Harderian Gland | + | 7 |
Adenoma | | 2 |
Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 55 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant | | 3 |
Lymphoma Malignant Mixed | X | 3 |
Capsule, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8| | |
| 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + | 54 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + | 55 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 3 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X X | 9 |
Lymphoma Malignant Mixed | X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|
| 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + A + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + +|
Adenocarcinoma | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Hemangioma, Marked | |
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Mesentery | + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|
| 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M + + M + + + + + + M + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Lymphoma Malignant | |
Lymphocytic | |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | |
Iliac, Lymphoma Malignant Histiocytic| |
Iliac, Lymphoma Malignant Lymphocytic| |
Inguinal, Lymphoma Malignant | |
Histiocytic | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + M + M|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|
| 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + M + M + M + M M + M + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Fibrosarcoma | X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | X |
Subcutaneous Tissue, Neurofibroma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Intercostal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|
| 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Urethra | +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|
| 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + A + + A + + + + + + + + + + M |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + A + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
Adenocarcinoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Skin | |
Hemangioma, Marked | |
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Mesentery | + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|
| 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M M + + + + M M |
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + |
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Bronchial, Lymphoma Malignant | |
Lymphocytic | X |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | X |
Iliac, Lymphoma Malignant Histiocytic| X |
Iliac, Lymphoma Malignant Lymphocytic| X |
Inguinal, Lymphoma Malignant | |
Histiocytic | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Pancreatic, Lymphoma Malignant | |
Histiocytic | X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Histiocytic| |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|
| 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | + + + M + + M M + M + + + + + M + M |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M + M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Fibroma | |
Fibrosarcoma | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X X X |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
Subcutaneous Tissue, Neurofibroma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
Intercostal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|
| 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3| | |
DAY ON TEST | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3| | |
| 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Gallbladder | + + A + M + + + M + + + A A | 44 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + A A + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + A + | 48 |
Adenocarcinoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 55 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Hemangioma, Marked | X | 1 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X X X X | 12 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X X | 9 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + + + + + | 54 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 55 |
Squamous Cell Papilloma | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Tooth | | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 55 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3| | |
DAY ON TEST | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3| | |
| 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 55 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 54 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + + + M + + + | 53 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + M + + + M + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M | 50 |
Pars Distalis, Adenoma | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 55 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + M + + + + + + + | 54 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 11 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + | 55 |
Interstitial Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 55 |
Bronchial, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Deep Cervical, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Iliac, Lymphoma Malignant Histiocytic| | 1 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Inguinal, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3| | |
DAY ON TEST | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3| | |
| 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocytic | X | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | X | 2 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 52 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + | 54 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + M + + + M + | 39 |
Lymphoma Malignant Lymphocytic | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 55 |
Fibroma | | 1 |
Fibrosarcoma | X | 2 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 5 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
Subcutaneous Tissue, Neurofibroma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 54 |
Osteosarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Intercostal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3| | |
DAY ON TEST | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3| | |
| 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Spinal Cord | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 55 |
Alveolar/Bronchiolar Adenoma | X X | 5 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X X X X | 8 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 5 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
Adenoma | X X | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Urethra | + | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 54 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 4| 4| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 5| 5| 6| 3| 3| 3| 3| 5| 3| 3| 5| 5| 1| 3| 2| 8| 4| 6| 3| 3| 3| 3| 2|
| 2| 1| 8| 8| 8| 1| 1| 0| 0| 8| 1| 0| 8| 8| 8| 1| 9| 8| 8| 5| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X|
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Lymphocytic | X |
Sinusoid, Sarcoma | |
__________________________________________________________________________|
Mesentery | + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pancreas | + + + A + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + A + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
Capsule, Lymphoma Malignant | |
Lymphocytic | X X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 4| 4| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 5| 5| 6| 3| 3| 3| 3| 5| 3| 3| 5| 5| 1| 3| 2| 8| 4| 6| 3| 3| 3| 3| 2|
| 2| 1| 8| 8| 8| 1| 1| 0| 0| 8| 1| 0| 8| 8| 8| 1| 9| 8| 8| 5| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Preputial Gland | + +|
__________________________________________________________________________|
Prostate | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Testes | + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Axillary, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X X |
Mediastinal, Lymphoma Malignant Mixed| |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | |
Thoracic, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + M + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 4| 4| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 5| 5| 6| 3| 3| 3| 3| 5| 3| 3| 5| 5| 1| 3| 2| 8| 4| 6| 3| 3| 3| 3| 2|
| 2| 1| 8| 8| 8| 1| 1| 0| 0| 8| 1| 0| 8| 8| 8| 1| 9| 8| 8| 5| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + M + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + |
Fibroma | X |
Fibrosarcoma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibroma, | |
Multiple | |
Subcutaneous Tissue, Fibrosarcoma | X X X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X X |
__________________________________________________________________________|
Nose | + + + + + + + |
Mucosa, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Trachea | + + + A + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Histiocytic Sarcoma | X |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 4| 4| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 5| 5| 6| 3| 3| 3| 3| 5| 3| 3| 5| 5| 1| 3| 2| 8| 4| 6| 3| 3| 3| 3| 2|
| 2| 1| 8| 8| 8| 1| 1| 0| 0| 8| 1| 0| 8| 8| 8| 1| 9| 8| 8| 5| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 0| 4|
DAY ON TEST | 3| 2| 2| 9| 5| 2| 2| 8| 5| 7| 2| 2| 2| 2| 5| 3| 3| 3| 3| 2| 3| 5| 4| 1| 5|
| 1| 9| 9| 1| 6| 9| 9| 4| 8| 9| 9| 9| 9| 9| 4| 1| 1| 1| 0| 9| 0| 2| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | M A + + A + M A |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + A + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + A |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X X X X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X |
Lymphoma Malignant Lymphocytic | |
Sinusoid, Sarcoma | |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + M |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + M + + + + + + + + + + + + + + + + + |
Capsule, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 0| 4|
DAY ON TEST | 3| 2| 2| 9| 5| 2| 2| 8| 5| 7| 2| 2| 2| 2| 5| 3| 3| 3| 3| 2| 3| 5| 4| 1| 5|
| 1| 9| 9| 1| 6| 9| 9| 4| 8| 9| 9| 9| 9| 9| 4| 1| 1| 1| 0| 9| 0| 2| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Preputial Gland | + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Testes | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Axillary, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | X |
Thoracic, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + A |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 0| 4|
DAY ON TEST | 3| 2| 2| 9| 5| 2| 2| 8| 5| 7| 2| 2| 2| 2| 5| 3| 3| 3| 3| 2| 3| 5| 4| 1| 5|
| 1| 9| 9| 1| 6| 9| 9| 4| 8| 9| 9| 9| 9| 9| 4| 1| 1| 1| 0| 9| 0| 2| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | M + M M + M M M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + |
Fibroma | |
Fibrosarcoma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibroma, | |
Multiple | X |
Subcutaneous Tissue, Fibrosarcoma | X X X |
Subcutaneous Tissue, Sarcoma | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Carcinoma | X |
__________________________________________________________________________|
Nose | + + + + + + + |
Mucosa, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Histiocytic Sarcoma | |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 0| 4|
DAY ON TEST | 3| 2| 2| 9| 5| 2| 2| 8| 5| 7| 2| 2| 2| 2| 5| 3| 3| 3| 3| 2| 3| 5| 4| 1| 5|
| 1| 9| 9| 1| 6| 9| 9| 4| 8| 9| 9| 9| 9| 9| 4| 1| 1| 1| 0| 9| 0| 2| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| | |
DAY ON TEST | 3| 2| 5| 5| 5| 3| 3| 3| 2| 5| 3| 3| 4| 3| 9| | |
| 0| 9| 4| 8| 8| 1| 0| 0| 9| 8| 1| 0| 1| 0| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 17 |
__________________________________________________________________________|____________|
Gallbladder | + A | 11 |
__________________________________________________________________________|____________|
Intestine Large | + A + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 14 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 15 |
__________________________________________________________________________|____________|
Intestine Small | + + A + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M | 10 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 13 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 54 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | | 11 |
Hepatocellular Adenoma | X X X X | 15 |
Hepatocellular Adenoma, Multiple | X X X | 6 |
Lymphoma Malignant Lymphocytic | | 1 |
Sinusoid, Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 15 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 16 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach | + A + | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 15 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 15 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 17 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 53 |
Capsule, Lymphoma Malignant | | |
Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| | |
DAY ON TEST | 3| 2| 5| 5| 5| 3| 3| 3| 2| 5| 3| 3| 4| 3| 9| | |
| 0| 9| 4| 8| 8| 1| 0| 0| 9| 8| 1| 0| 1| 0| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 52 |
Pheochromocytoma Benign | | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 15 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + | 14 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 53 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + | 17 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 9 |
__________________________________________________________________________|____________|
Prostate | + + + | 17 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 17 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Testes | + + + | 18 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 17 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 29 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | | 2 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| | |
DAY ON TEST | 3| 2| 5| 5| 5| 3| 3| 3| 2| 5| 3| 3| 4| 3| 9| | |
| 0| 9| 4| 8| 8| 1| 0| 0| 9| 8| 1| 0| 1| 0| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Thoracic, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 17 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 23 |
Lymphoma Malignant Lymphocytic | X | 6 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 52 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Thymus | + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + | 33 |
Fibroma | | 1 |
Fibrosarcoma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibroma, | | |
Multiple | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X X | 8 |
Subcutaneous Tissue, Sarcoma | | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 17 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 31 |
Alveolar/Bronchiolar Adenoma | X X | 9 |
Alveolar/Bronchiolar Carcinoma | | 4 |
__________________________________________________________________________|____________|
Nose | + + + | 17 |
Mucosa, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 72
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| | |
DAY ON TEST | 3| 2| 5| 5| 5| 3| 3| 3| 2| 5| 3| 3| 4| 3| 9| | |
| 0| 9| 4| 8| 8| 1| 0| 0| 9| 8| 1| 0| 1| 0| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 17 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + | 54 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X X | 9 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 73
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 4| 3|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 2| 2| 5| 3| 3| 3| 2| 2| 3| 3| 2| 2| 5| 8| 3| 8| 5| 3|
| 0| 0| 4| 3| 8| 1| 0| 9| 5| 8| 1| 0| 0| 6| 9| 1| 0| 9| 9| 8| 1| 1| 0| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + A +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + A + + + + + + + A +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + A + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + +|
Serosa, Carcinoid Tumor Benign | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + A + + + + + + + A +|
Lymphoma Malignant Lymphocytic | |
Jejunum, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + A + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + +|
Lymphoma Malignant Histiocytic | X|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Pericardium, Lymphoma Malignant | |
Histiocytic | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 4| 3|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 2| 2| 5| 3| 3| 3| 2| 2| 3| 3| 2| 2| 5| 8| 3| 8| 5| 3|
| 0| 0| 4| 3| 8| 1| 0| 9| 5| 8| 1| 0| 0| 6| 9| 1| 0| 9| 9| 8| 1| 1| 0| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Iliac, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Lymphocytic| X |
Thoracic, Lymphoma Malignant | |
Histiocytic | X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + M + M + + + M + + + + +|
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + A + + + + + + + + +|
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + M M|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 4| 3|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 2| 2| 5| 3| 3| 3| 2| 2| 3| 3| 2| 2| 5| 8| 3| 8| 5| 3|
| 0| 0| 4| 3| 8| 1| 0| 9| 5| 8| 1| 0| 0| 6| 9| 1| 0| 9| 9| 8| 1| 1| 0| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibrosarcoma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 4| 3|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 2| 2| 5| 3| 3| 3| 2| 2| 3| 3| 2| 2| 5| 8| 3| 8| 5| 3|
| 0| 0| 4| 3| 8| 1| 0| 9| 5| 8| 1| 0| 0| 6| 9| 1| 0| 9| 9| 8| 1| 1| 0| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 5| 4| 5| 5| 3| 3| 3| 9| 5| 3| 3| 2| 5| 3| 3| 2| 4| 5| 5|
| 1| 0| 9| 9| 3| 0| 7| 2| 8| 8| 1| 1| 0| 7| 8| 1| 0| 9| 5| 5| 0| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + A + M + + + + + + + + M M + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + A + + + + + + + A + + + + |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A A + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + |
Serosa, Carcinoid Tumor Benign | |
__________________________________________________________________________|
Intestine Small | + + + + A + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + A + + + + + + + A + + + + |
Lymphoma Malignant Lymphocytic | X |
Jejunum, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + A + + + + + + + A + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Hemangioma | X |
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Pericardium, Lymphoma Malignant | |
Histiocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 5| 4| 5| 5| 3| 3| 3| 9| 5| 3| 3| 2| 5| 3| 3| 2| 4| 5| 5|
| 1| 0| 9| 9| 3| 0| 7| 2| 8| 8| 1| 1| 0| 7| 8| 1| 0| 9| 5| 5| 0| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + M + + + M + + M + |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + |
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Iliac, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Lymphocytic| |
Thoracic, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + M + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | + + + + M + M M + + + M + + + + + + M + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M + M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 5| 4| 5| 5| 3| 3| 3| 9| 5| 3| 3| 2| 5| 3| 3| 2| 4| 5| 5|
| 1| 0| 9| 9| 3| 0| 7| 2| 8| 8| 1| 1| 0| 7| 8| 1| 0| 9| 5| 5| 0| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibrosarcoma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Hemangiosarcoma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X X |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 5| 4| 5| 5| 3| 3| 3| 9| 5| 3| 3| 2| 5| 3| 3| 2| 4| 5| 5|
| 1| 0| 9| 9| 3| 0| 7| 2| 8| 8| 1| 1| 0| 7| 8| 1| 0| 9| 5| 5| 0| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8| | |
| 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + + + M + | 48 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + | 52 |
Serosa, Carcinoid Tumor Benign | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + M | 47 |
Lymphoma Malignant Lymphocytic | | 1 |
Jejunum, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + M + + + + + A | 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 55 |
Hemangioma | | 1 |
Hemangiosarcoma | X | 2 |
Hepatocellular Carcinoma | X | 7 |
Hepatocellular Adenoma | X X X X X X X | 15 |
Hepatocellular Adenoma, Multiple | X X | 5 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 5 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + | 53 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + M + + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 55 |
Pericardium, Lymphoma Malignant | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8| | |
| 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Histiocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + M + + + + | 54 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + + + M + + M + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + M + + + + | 50 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 54 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Preputial Gland | + | 7 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + | 55 |
Interstitial Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 55 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Thoracic, Lymphoma Malignant | | |
Histiocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 51 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + | 50 |
Lymphoma Malignant Histiocytic | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 83
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8| | |
| 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 54 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + + M M M | 42 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 55 |
Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X X | 2 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 55 |
Alveolar/Bronchiolar Adenoma | | 3 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X | 6 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 3 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 84
NTP Experiment-Test: 05040-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:15:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8| | |
| 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 7 |
Adenoma | X X | 6 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urethra | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + | 55 |
Lymphoma Malignant Histiocytic | X | 2 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
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