TDMS Study 05040-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: American Biogenics HYDROQUINONE DATE: 09/05/94
EXPERIMENT: 05040 TEST: 02 TIME: 12:08:24
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: ROUTE: GAVAGE NTP C#: 55834B
PATHOLOGIST: S. WYAND S. EUSTIS CAS: 000123319
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: American Biogenics HYDROQUINONE DATE: 09/05/94
EXPERIMENT: 05040 TEST: 02 TIME: 12:08:24
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: ROUTE: GAVAGE NTP C#: 55834B
PATHOLOGIST: S. WYAND S. EUSTIS CAS: 000123319
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: American Biogenics HYDROQUINONE DATE: 09/05/94
EXPERIMENT: 05040 TEST: 02 TIME: 12:08:24
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: ROUTE: GAVAGE NTP C#: 55834B
PATHOLOGIST: S. WYAND S. EUSTIS CAS: 000123319
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF HYDROQUINONE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Lung Alveolar/Bronchiolar Adenoma
Skin: Subcutaneous Tissue Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
All Organs Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
====================================================================================================
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/55 (4%) 2/52 (4%) 0/54 (0%) | 0/55 (0%) 0/13 (0%) 0/55 (0%) |
|ADJUSTED (b) | 6.1% 5.6% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/33 (6%) 2/36 (6%) 0/35 (0%) | 0/37 (0%) 0/0 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.161N P=0.664N P=0.225N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.161N P=0.664N P=0.225N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.161N P=0.664N P=0.225N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.182N | (e) |
|FISHER EXACT | P=0.670 P=0.252N | (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/54 (2%) 3/52 (6%) 0/54 (0%) | 1/51 (2%) 0/11 (0%) 0/52 (0%) |
|ADJUSTED (b) | 2.6% 8.3% 0.0% | 2.5% 0.0% 0.0% |
|TERMINAL (d) | 0/32 (0%) 3/36 (8%) 0/35 (0%) | 0/34 (0%) 0/0 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 691 729 (T) --- | 691 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.359N P=0.341 P=0.505N | P=0.268N P=0.490N P=0.500N |
|INCIDENTAL TUMOR | P=0.373N P=0.312 P=0.536N | P=0.248N P=0.500N P=0.464N |
|LOGISTIC REGRESSION | P=0.366N P=0.311 P=0.498N | P=0.300N P=0.848N P=0.500N |
|COCHRAN-ARMITAGE | P=0.379N | P=0.295N |
|FISHER EXACT | P=0.295 P=0.500N | P=0.823N P=0.495N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/54 (2%) 3/52 (6%) 0/54 (0%) | 2/51 (4%) 0/11 (0%) 0/52 (0%) |
|ADJUSTED (b) | 2.6% 8.3% 0.0% | 5.4% 0.0% 0.0% |
|TERMINAL (d) | 0/32 (0%) 3/36 (8%) 0/35 (0%) | 1/34 (3%) 0/0 0/35 (0%) |
|FIRST INCIDENCE (DAYS) | 691 729 (T) --- | 691 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.359N P=0.341 P=0.505N | P=0.120N P=0.490N P=0.237N |
|INCIDENTAL TUMOR | P=0.373N P=0.312 P=0.536N | P=0.112N P=0.500N P=0.217N |
|LOGISTIC REGRESSION | P=0.366N P=0.311 P=0.498N | P=0.129N P=0.734N P=0.233N |
|COCHRAN-ARMITAGE | P=0.379N | P=0.127N |
|FISHER EXACT | P=0.295 P=0.500N | P=0.674N P=0.243N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/55 (9%) 2/54 (4%) 6/55 (11%) | 2/55 (4%) 2/55 (4%) 2/55 (4%) |
|ADJUSTED (b) | 12.6% 5.4% 15.8% | 5.2% 5.1% 5.6% |
|TERMINAL (d) | 2/33 (6%) 2/37 (5%) 5/36 (14%) | 1/37 (3%) 2/39 (5%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | 635 729 (T) 649 | 693 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.470 P=0.192N P=0.544 | P=0.594 P=0.672N P=0.688 |
|INCIDENTAL TUMOR | P=0.450 P=0.263N P=0.515 | P=0.592N P=0.653N P=0.675N |
|LOGISTIC REGRESSION | P=0.447 P=0.220N P=0.518 | P=0.596N P=0.664N P=0.692N |
|COCHRAN-ARMITAGE | P=0.430 | P=0.601 |
|FISHER EXACT | P=0.226N P=0.500 | P=0.691N P=0.691N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/55 (0%) 0/54 (0%) 0/55 (0%) | 0/55 (0%) 0/55 (0%) 2/55 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 4.9% |
|TERMINAL (d) | 0/33 (0%) 0/37 (0%) 0/36 (0%) | 0/37 (0%) 0/39 (0%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 641 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.097 (e) P=0.244 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.094 (e) P=0.237 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.093 (e) P=0.233 |
|COCHRAN-ARMITAGE | (e) | P=0.096 |
|FISHER EXACT | (e) (e) | (e) P=0.248 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/55 (9%) 2/54 (4%) 6/55 (11%) | 2/55 (4%) 2/55 (4%) 4/55 (7%) |
|ADJUSTED (b) | 12.6% 5.4% 15.8% | 5.2% 5.1% 10.3% |
|TERMINAL (d) | 2/33 (6%) 2/37 (5%) 5/36 (14%) | 1/37 (3%) 2/39 (5%) 3/36 (8%) |
|FIRST INCIDENCE (DAYS) | 635 729 (T) 649 | 693 735 (T) 641 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.470 P=0.192N P=0.544 | P=0.249 P=0.672N P=0.338 |
|INCIDENTAL TUMOR | P=0.450 P=0.263N P=0.515 | P=0.257 P=0.653N P=0.353 |
|LOGISTIC REGRESSION | P=0.447 P=0.220N P=0.518 | P=0.248 P=0.664N P=0.331 |
|COCHRAN-ARMITAGE | P=0.430 | P=0.253 |
|FISHER EXACT | P=0.226N P=0.500 | P=0.691N P=0.339 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/55 (2%) 1/54 (2%) 2/55 (4%) | 1/55 (2%) 0/55 (0%) 0/55 (0%) |
|ADJUSTED (b) | 3.0% 2.7% 4.9% | 2.7% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 1/37 (3%) 1/36 (3%) | 1/37 (3%) 0/39 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 655 | 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.402 P=0.736N P=0.525 | P=0.271N P=0.489N P=0.505N |
|INCIDENTAL TUMOR | P=0.383 P=0.736N P=0.499 | P=0.271N P=0.489N P=0.505N |
|LOGISTIC REGRESSION | P=0.388 P=0.736N P=0.509 | P=0.271N P=0.489N P=0.505N |
|COCHRAN-ARMITAGE | P=0.379 | P=0.270N |
|FISHER EXACT | P=0.748 P=0.500 | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/55 (16%) 21/54 (39%) 20/55 (36%) | 2/55 (4%) 15/55 (27%) 12/55 (22%) |
|ADJUSTED (b) | 25.5% 49.3% 51.1% | 5.4% 36.2% 30.3% |
|TERMINAL (d) | 7/33 (21%) 16/37 (43%) 17/36 (47%) | 2/37 (5%) 13/39 (33%) 9/36 (25%) |
|FIRST INCIDENCE (DAYS) | 694 441 661 | 735 (T) 534 656 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.025 * P=0.022 * P=0.025 * | P=0.007 ** P=0.001 ** P=0.005 ** |
|INCIDENTAL TUMOR | P=0.015 * P=0.016 * P=0.017 * | P=0.005 ** P<0.001 ** P=0.006 ** |
|LOGISTIC REGRESSION | P=0.018 * P=0.008 ** P=0.015 * | P=0.007 ** P=0.001 ** P=0.005 ** |
|COCHRAN-ARMITAGE | P=0.015 * | P=0.009 ** |
|FISHER EXACT | P=0.007 ** P=0.015 * | P<0.001 ** P=0.004 ** |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/55 (24%) 11/54 (20%) 7/55 (13%) | 1/55 (2%) 2/55 (4%) 2/55 (4%) |
|ADJUSTED (b) | 29.6% 24.8% 16.8% | 2.7% 4.0% 5.6% |
|TERMINAL (d) | 5/33 (15%) 5/37 (14%) 4/36 (11%) | 1/37 (3%) 0/39 (0%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | 537 465 526 | 735 (T) 534 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.088N P=0.367N P=0.106N | P=0.386 P=0.528 P=0.490 |
|INCIDENTAL TUMOR | P=0.099N P=0.524N P=0.111N | P=0.294 P=0.461 P=0.490 |
|LOGISTIC REGRESSION | P=0.064N P=0.521N P=0.078N | P=0.387 P=0.449 P=0.490 |
|COCHRAN-ARMITAGE | P=0.090N | P=0.390 |
|FISHER EXACT | P=0.429N P=0.108N | P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/55 (36%) 29/54 (54%) 25/55 (45%) | 3/55 (5%) 16/55 (29%) 13/55 (24%) |
|ADJUSTED (b) | 46.2% 64.1% 59.0% | 8.1% 37.6% 32.9% |
|TERMINAL (d) | 11/33 (33%) 21/37 (57%) 19/36 (53%) | 3/37 (8%) 13/39 (33%) 10/36 (28%) |
|FIRST INCIDENCE (DAYS) | 537 441 526 | 735 (T) 534 656 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.299 P=0.151 P=0.317 | P=0.009 ** P=0.002 ** P=0.007 ** |
|INCIDENTAL TUMOR | P=0.213 P=0.061 P=0.247 | P=0.007 ** P=0.002 ** P=0.008 ** |
|LOGISTIC REGRESSION | P=0.222 P=0.053 P=0.249 | P=0.009 ** P=0.002 ** P=0.007 ** |
|COCHRAN-ARMITAGE | P=0.194 | P=0.011 * |
|FISHER EXACT | P=0.052 P=0.219 | P<0.001 ** P=0.006 ** |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/55 (36%) 29/54 (54%) 25/55 (45%) | 3/55 (5%) 16/55 (29%) 13/55 (24%) |
|ADJUSTED (b) | 46.2% 64.1% 59.0% | 8.1% 37.6% 32.9% |
|TERMINAL (d) | 11/33 (33%) 21/37 (57%) 19/36 (53%) | 3/37 (8%) 13/39 (33%) 10/36 (28%) |
|FIRST INCIDENCE (DAYS) | 537 441 526 | 735 (T) 534 656 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.299 P=0.151 P=0.317 | P=0.009 ** P=0.002 ** P=0.007 ** |
|INCIDENTAL TUMOR | P=0.213 P=0.061 P=0.247 | P=0.007 ** P=0.002 ** P=0.008 ** |
|LOGISTIC REGRESSION | P=0.222 P=0.053 P=0.249 | P=0.009 ** P=0.002 ** P=0.007 ** |
|COCHRAN-ARMITAGE | P=0.194 | P=0.011 * |
|FISHER EXACT | P=0.052 P=0.219 | P<0.001 ** P=0.006 ** |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/55 (11%) 9/31 (29%) 4/55 (7%) | 3/55 (5%) 6/55 (11%) 2/55 (4%) |
|ADJUSTED (b) | 18.2% 58.3% 11.1% | 7.1% 14.4% 5.6% |
|TERMINAL (d) | 6/33 (18%) 8/14 (57%) 4/36 (11%) | 1/37 (3%) 4/39 (10%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 701 729 (T) | 558 660 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.271N P=0.006 ** P=0.313N | P=0.434N P=0.283 P=0.507N |
|INCIDENTAL TUMOR | P=0.278N P=0.006 ** P=0.313N | P=0.392N P=0.308 P=0.482N |
|LOGISTIC REGRESSION | P=0.288N P=0.004 ** P=0.313N | P=0.435N P=0.256 P=0.510N |
|COCHRAN-ARMITAGE | P=0.338N | P=0.424N |
|FISHER EXACT | P=0.035 * P=0.371N | P=0.244 P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/55 (15%) 4/31 (13%) 6/55 (11%) | 1/55 (2%) 0/55 (0%) 2/55 (4%) |
|ADJUSTED (b) | 21.1% 23.3% 14.7% | 2.7% 0.0% 5.6% |
|TERMINAL (d) | 4/33 (12%) 3/14 (21%) 3/36 (8%) | 1/37 (3%) 0/39 (0%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | 649 662 563 | 735 (T) --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.297N P=0.467N P=0.354N | P=0.352 P=0.489N P=0.490 |
|INCIDENTAL TUMOR | P=0.333N P=0.538N P=0.403N | P=0.352 P=0.489N P=0.490 |
|LOGISTIC REGRESSION | P=0.314N P=0.615 P=0.371N | P=0.352 P=0.489N P=0.490 |
|COCHRAN-ARMITAGE | P=0.334N | P=0.361 |
|FISHER EXACT | P=0.554N P=0.388N | P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/55 (25%) 11/31 (35%) 10/55 (18%) | 4/55 (7%) 6/55 (11%) 4/55 (7%) |
|ADJUSTED (b) | 37.4% 66.1% 25.0% | 9.6% 14.4% 11.1% |
|TERMINAL (d) | 10/33 (30%) 9/14 (64%) 7/36 (19%) | 2/37 (5%) 4/39 (10%) 4/36 (11%) |
|FIRST INCIDENCE (DAYS) | 649 662 563 | 558 660 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.164N P=0.185 P=0.197N | P=0.556 P=0.414 P=0.631 |
|INCIDENTAL TUMOR | P=0.185N P=0.131 P=0.223N | P=0.544N P=0.445 P=0.634N |
|LOGISTIC REGRESSION | P=0.186N P=0.076 P=0.213N | P=0.560 P=0.393 P=0.633 |
|COCHRAN-ARMITAGE | P=0.220N | P=0.568 |
|FISHER EXACT | P=0.230 P=0.245N | P=0.371 P=0.642N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/55 (0%) 0/54 (0%) 0/55 (0%) | 3/55 (5%) 5/55 (9%) 2/55 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 7.2% 12.8% 5.0% |
|TERMINAL (d) | 0/33 (0%) 0/37 (0%) 0/36 (0%) | 2/37 (5%) 5/39 (13%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 372 735 (T) 656 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.434N P=0.384 P=0.512N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.497N P=0.336 P=0.615N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.430N P=0.355 P=0.491N |
|COCHRAN-ARMITAGE | (e) | P=0.421N |
|FISHER EXACT | (e) (e) | P=0.358 P=0.500N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/14 (0%) 0/50 (0%) | 11/52 (21%) 14/29 (48%) 11/52 (21%) |
|ADJUSTED (b) | 9.3% 0.0% 0.0% | 30.0% 76.0% 29.8% |
|TERMINAL (d) | 2/30 (7%) 0/0 0/31 (0%) | 9/34 (26%) 12/16 (75%) 8/33 (24%) |
|FIRST INCIDENCE (DAYS) | 701 --- --- | 664 616 644 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.058N P=0.484N P=0.117N | P=0.518 P=0.007 ** P=0.575 |
|INCIDENTAL TUMOR | P=0.065N P=0.590N P=0.124N | P=0.542N P=0.006 ** P=0.566N |
|LOGISTIC REGRESSION | P=0.067N P=0.786N P=0.120N | P=0.530N P=0.008 ** P=0.585N |
|COCHRAN-ARMITAGE | P=0.059N | P=0.544N |
|FISHER EXACT | P=0.470N P=0.121N | P=0.012 * P=0.595N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/14 (0%) 0/50 (0%) | 1/52 (2%) 2/29 (7%) 0/52 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 2.2% 8.4% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/0 0/31 (0%) | 0/34 (0%) 1/16 (6%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 631 683 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.365N P=0.432 P=0.496N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.346N P=0.408 P=0.500N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.376N P=0.302 P=0.492N |
|COCHRAN-ARMITAGE | (e) | P=0.371N |
|FISHER EXACT | (e) (e) | P=0.290 P=0.500N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/14 (0%) 0/50 (0%) | 12/52 (23%) 16/29 (55%) 11/52 (21%) |
|ADJUSTED (b) | 9.3% 0.0% 0.0% | 31.5% 82.4% 29.8% |
|TERMINAL (d) | 2/30 (7%) 0/0 0/31 (0%) | 9/34 (26%) 13/16 (81%) 8/33 (24%) |
|FIRST INCIDENCE (DAYS) | 701 --- --- | 631 616 644 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.058N P=0.484N P=0.117N | P=0.482N P=0.005 ** P=0.518N |
|INCIDENTAL TUMOR | P=0.065N P=0.590N P=0.124N | P=0.446N P=0.003 ** P=0.470N |
|LOGISTIC REGRESSION | P=0.067N P=0.786N P=0.120N | P=0.448N P=0.003 ** P=0.497N |
|COCHRAN-ARMITAGE | P=0.059N | P=0.457N |
|FISHER EXACT | P=0.470N P=0.121N | P=0.004 ** P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/55 (4%) 1/54 (2%) 1/55 (2%) | 0/55 (0%) 0/55 (0%) 0/55 (0%) |
|ADJUSTED (b) | 4.8% 2.4% 2.3% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/37 (0%) 0/36 (0%) | 0/37 (0%) 0/39 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 648 662 661 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.382N P=0.495N P=0.501N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.437N P=0.566N P=0.566N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.386N P=0.507N P=0.511N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.379N | (e) |
|FISHER EXACT | P=0.507N P=0.500N | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/55 (2%) 2/54 (4%) 0/55 (0%) | 0/55 (0%) 0/55 (0%) 0/55 (0%) |
|ADJUSTED (b) | 3.0% 5.4% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 2/37 (5%) 0/36 (0%) | 0/37 (0%) 0/39 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.336N P=0.540 P=0.483N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.336N P=0.540 P=0.483N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.336N P=0.540 P=0.483N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.361N | (e) |
|FISHER EXACT | P=0.493 P=0.500N | (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/55 (9%) 8/54 (15%) 2/55 (4%) | 1/55 (2%) 1/55 (2%) 0/55 (0%) |
|ADJUSTED (b) | 12.1% 18.9% 5.6% | 2.4% 2.5% 0.0% |
|TERMINAL (d) | 1/33 (3%) 4/37 (11%) 2/36 (6%) | 0/37 (0%) 0/39 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 635 596 729 (T) | 676 729 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.189N P=0.326 P=0.209N | P=0.330N P=0.744N P=0.500N |
|INCIDENTAL TUMOR | P=0.208N P=0.169 P=0.224N | P=0.267N P=0.702N P=0.443N |
|LOGISTIC REGRESSION | P=0.197N P=0.268 P=0.211N | P=0.335N P=0.756N P=0.503N |
|COCHRAN-ARMITAGE | P=0.204N | P=0.332N |
|FISHER EXACT | P=0.266 P=0.219N | P=0.752N P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibroma or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/55 (4%) 2/54 (4%) 0/55 (0%) | 0/55 (0%) 0/55 (0%) 0/55 (0%) |
|ADJUSTED (b) | 6.1% 5.4% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/33 (6%) 2/37 (5%) 0/36 (0%) | 0/37 (0%) 0/39 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.155N P=0.654N P=0.219N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.155N P=0.654N P=0.219N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.154N P=0.654N P=0.219N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.177N | (e) |
|FISHER EXACT | P=0.684 P=0.248N | (e) (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 8/55 (15%) 12/54 (22%) 2/55 (4%) | 1/55 (2%) 1/55 (2%) 0/55 (0%) |
|ADJUSTED (b) | 19.7% 28.8% 5.6% | 2.4% 2.5% 0.0% |
|TERMINAL (d) | 3/33 (9%) 8/37 (22%) 2/36 (6%) | 0/37 (0%) 0/39 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 635 596 729 (T) | 676 729 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.054N P=0.300 P=0.048N* | P=0.330N P=0.744N P=0.500N |
|INCIDENTAL TUMOR | P=0.060N P=0.165 P=0.050N | P=0.267N P=0.702N P=0.443N |
|LOGISTIC REGRESSION | P=0.055N P=0.222 P=0.045N* | P=0.335N P=0.756N P=0.503N |
|COCHRAN-ARMITAGE | P=0.062N | P=0.332N |
|FISHER EXACT | P=0.216 P=0.047N* | P=0.752N P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/55 (11%) 11/54 (20%) 2/55 (4%) | 1/55 (2%) 1/55 (2%) 0/55 (0%) |
|ADJUSTED (b) | 14.3% 26.3% 5.6% | 2.4% 2.5% 0.0% |
|TERMINAL (d) | 1/33 (3%) 7/37 (19%) 2/36 (6%) | 0/37 (0%) 0/39 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 635 596 729 (T) | 676 729 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.135N P=0.197 P=0.135N | P=0.330N P=0.744N P=0.500N |
|INCIDENTAL TUMOR | P=0.149N P=0.085 P=0.145N | P=0.267N P=0.702N P=0.443N |
|LOGISTIC REGRESSION | P=0.139N P=0.139 P=0.130N | P=0.335N P=0.756N P=0.503N |
|COCHRAN-ARMITAGE | P=0.149N | P=0.332N |
|FISHER EXACT | P=0.136 P=0.135N | P=0.752N P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/55 (2%) 3/54 (6%) 0/55 (0%) | 0/55 (0%) 0/55 (0%) 0/55 (0%) |
|ADJUSTED (b) | 2.5% 8.1% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 3/37 (8%) 0/36 (0%) | 0/37 (0%) 0/39 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 683 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.361N P=0.340 P=0.510N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.373N P=0.321 P=0.536N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.367N P=0.312 P=0.500N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.379N | (e) |
|FISHER EXACT | P=0.302 P=0.500N | (e) (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/55 (4%) 0/54 (0%) 0/55 (0%) | 0/55 (0%) 1/55 (2%) 0/55 (0%) |
|ADJUSTED (b) | 5.1% 0.0% 0.0% | 0.0% 2.6% 0.0% |
|TERMINAL (d) | 1/33 (3%) 0/37 (0%) 0/36 (0%) | 0/37 (0%) 1/39 (3%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 635 --- --- | --- 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.089N P=0.225N P=0.226N | P=0.729 P=0.511 (e) |
|INCIDENTAL TUMOR | P=0.094N P=0.320N P=0.211N | P=0.729 P=0.511 (e) |
|LOGISTIC REGRESSION | P=0.096N P=0.242N P=0.238N | P=0.729 P=0.511 (e) |
|COCHRAN-ARMITAGE | P=0.096N | P=0.730 |
|FISHER EXACT | P=0.252N P=0.248N | P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/55 (2%) 0/18 (0%) 3/55 (5%) | |
|ADJUSTED (b) | 2.6% 0.0% 8.3% | |
|TERMINAL (d) | 0/33 (0%) 0/1 (0%) 3/36 (8%) | |
|FIRST INCIDENCE (DAYS) | 691 --- 729 (T) | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.231 P=0.495N P=0.328 | |
|INCIDENTAL TUMOR | P=0.223 P=0.536N P=0.313 | |
|LOGISTIC REGRESSION | P=0.226 P=0.802N P=0.318 | |
|COCHRAN-ARMITAGE | P=0.206 | |
|FISHER EXACT | P=0.753N P=0.309 | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/55 (4%) 1/53 (2%) 2/54 (4%) | 3/55 (5%) 5/55 (9%) 6/55 (11%) |
|ADJUSTED (b) | 5.7% 2.8% 5.2% | 7.7% 12.2% 15.3% |
|TERMINAL (d) | 1/33 (3%) 1/36 (3%) 1/35 (3%) | 2/37 (5%) 4/39 (10%) 4/36 (11%) |
|FIRST INCIDENCE (DAYS) | 694 729 (T) 663 | 664 668 548 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.597N P=0.477N P=0.682N | P=0.190 P=0.394 P=0.240 |
|INCIDENTAL TUMOR | P=0.595 P=0.501N P=0.672 | P=0.212 P=0.419 P=0.268 |
|LOGISTIC REGRESSION | P=0.606N P=0.501N P=0.693N | P=0.186 P=0.397 P=0.233 |
|COCHRAN-ARMITAGE | P=0.602 | P=0.196 |
|FISHER EXACT | P=0.514N P=0.684 | P=0.358 P=0.244 |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/55 (4%) 1/53 (2%) 2/54 (4%) | 3/55 (5%) 5/55 (9%) 7/55 (13%) |
|ADJUSTED (b) | 5.7% 2.8% 5.2% | 7.7% 12.2% 17.9% |
|TERMINAL (d) | 1/33 (3%) 1/36 (3%) 1/35 (3%) | 2/37 (5%) 4/39 (10%) 5/36 (14%) |
|FIRST INCIDENCE (DAYS) | 694 729 (T) 663 | 664 668 548 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.597N P=0.477N P=0.682N | P=0.118 P=0.394 P=0.157 |
|INCIDENTAL TUMOR | P=0.595 P=0.501N P=0.672 | P=0.132 P=0.419 P=0.177 |
|LOGISTIC REGRESSION | P=0.606N P=0.501N P=0.693N | P=0.115 P=0.397 P=0.152 |
|COCHRAN-ARMITAGE | P=0.602 | P=0.123 |
|FISHER EXACT | P=0.514N P=0.684 | P=0.358 P=0.160 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/55 (2%) 0/54 (0%) 1/55 (2%) | 1/55 (2%) 2/55 (4%) 0/55 (0%) |
|ADJUSTED (b) | 2.0% 0.0% 2.4% | 2.7% 5.1% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/37 (0%) 0/36 (0%) | 1/37 (3%) 2/39 (5%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 604 --- 663 | 735 (T) 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.664N P=0.508N P=0.758N | P=0.366N P=0.518 P=0.505N |
|INCIDENTAL TUMOR | P=0.653N P=0.682N P=0.761 | P=0.366N P=0.518 P=0.505N |
|LOGISTIC REGRESSION | P=0.654 P=0.500N P=0.743 | P=0.366N P=0.518 P=0.505N |
|COCHRAN-ARMITAGE | P=0.668 | P=0.361N |
|FISHER EXACT | P=0.505N P=0.752N | P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/55 (2%) 1/54 (2%) 3/55 (5%) | 1/55 (2%) 0/55 (0%) 1/55 (2%) |
|ADJUSTED (b) | 3.0% 2.7% 7.7% | 2.7% 0.0% 2.8% |
|TERMINAL (d) | 1/33 (3%) 1/37 (3%) 2/36 (6%) | 1/37 (3%) 0/39 (0%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 655 | 735 (T) --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.222 P=0.736N P=0.334 | P=0.664 P=0.489N P=0.756 |
|INCIDENTAL TUMOR | P=0.209 P=0.736N P=0.313 | P=0.664 P=0.489N P=0.756 |
|LOGISTIC REGRESSION | P=0.211 P=0.736N P=0.316 | P=0.664 P=0.489N P=0.756 |
|COCHRAN-ARMITAGE | P=0.203 | P=0.668N |
|FISHER EXACT | P=0.748 P=0.309 | P=0.500N P=0.752N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/55 (4%) 1/54 (2%) 4/55 (7%) | 2/55 (4%) 2/55 (4%) 1/55 (2%) |
|ADJUSTED (b) | 5.0% 2.7% 9.9% | 5.4% 5.1% 2.8% |
|TERMINAL (d) | 1/33 (3%) 1/37 (3%) 2/36 (6%) | 2/37 (5%) 2/39 (5%) 1/36 (3%) |
|FIRST INCIDENCE (DAYS) | 604 729 (T) 655 | 735 (T) 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.261 P=0.478N P=0.365 | P=0.399N P=0.676N P=0.510N |
|INCIDENTAL TUMOR | P=0.254 P=0.575N P=0.345 | P=0.399N P=0.676N P=0.510N |
|LOGISTIC REGRESSION | P=0.243 P=0.506N P=0.337 | P=0.399N P=0.677N P=0.510N |
|COCHRAN-ARMITAGE | P=0.240 | P=0.390N |
|FISHER EXACT | P=0.507N P=0.339 | P=0.691N P=0.500N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/55 (11%) 12/54 (22%) 7/55 (13%) | 23/55 (42%) 12/55 (22%) 20/55 (36%) |
|ADJUSTED (b) | 15.2% 28.7% 17.1% | 52.8% 25.4% 43.4% |
|TERMINAL (d) | 3/33 (9%) 8/37 (22%) 5/36 (14%) | 17/37 (46%) 6/39 (15%) 10/36 (28%) |
|FIRST INCIDENCE (DAYS) | 330 648 330 | 469 409 622 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.502 P=0.147 P=0.548 | P=0.331N P=0.018N* P=0.375N |
|INCIDENTAL TUMOR | P=0.426 P=0.075 P=0.472 | P=0.353N P=0.018N* P=0.381N |
|LOGISTIC REGRESSION | P=0.439 P=0.092 P=0.447 | P=0.403N P=0.021N* P=0.388N |
|COCHRAN-ARMITAGE | P=0.447 | P=0.307N |
|FISHER EXACT | P=0.091 P=0.500 | P=0.020N* P=0.348N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/55 (11%) 11/54 (20%) 7/55 (13%) | 23/55 (42%) 12/55 (22%) 19/55 (35%) |
|ADJUSTED (b) | 15.2% 26.3% 17.1% | 52.8% 25.4% 41.2% |
|TERMINAL (d) | 3/33 (9%) 7/37 (19%) 5/36 (14%) | 17/37 (46%) 6/39 (15%) 9/36 (25%) |
|FIRST INCIDENCE (DAYS) | 330 648 330 | 469 409 622 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.499 P=0.203 P=0.548 | P=0.266N P=0.018N* P=0.309N |
|INCIDENTAL TUMOR | P=0.422 P=0.110 P=0.472 | P=0.276N P=0.018N* P=0.305N |
|LOGISTIC REGRESSION | P=0.436 P=0.137 P=0.447 | P=0.324N P=0.021N* P=0.313N |
|COCHRAN-ARMITAGE | P=0.446 | P=0.238N |
|FISHER EXACT | P=0.136 P=0.500 | P=0.020N* P=0.278N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 23/55 (42%) 31/54 (57%) 29/55 (53%) | 21/55 (38%) 33/55 (60%) 27/55 (49%) |
|ADJUSTED (b) | 56.8% 71.8% 70.5% | 48.3% 71.4% 62.4% |
|TERMINAL (d) | 16/33 (48%) 25/37 (68%) 24/36 (67%) | 15/37 (41%) 26/39 (67%) 20/36 (56%) |
|FIRST INCIDENCE (DAYS) | 604 441 649 | 406 534 548 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.250 P=0.208 P=0.276 | P=0.144 P=0.049 * P=0.168 |
|INCIDENTAL TUMOR | P=0.176 P=0.116 P=0.210 | P=0.118 P=0.034 * P=0.157 |
|LOGISTIC REGRESSION | P=0.179 P=0.078 P=0.198 | P=0.115 P=0.032 * P=0.136 |
|COCHRAN-ARMITAGE | P=0.147 | P=0.147 |
|FISHER EXACT | P=0.075 P=0.170 | P=0.018 * P=0.168 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 30/55 (55%) 34/54 (63%) 23/55 (42%) | 31/55 (56%) 21/55 (38%) 27/55 (49%) |
|ADJUSTED (b) | 59.7% 69.4% 48.8% | 65.4% 41.1% 57.4% |
|TERMINAL (d) | 13/33 (39%) 22/37 (59%) 13/36 (36%) | 21/37 (57%) 10/39 (26%) 16/36 (44%) |
|FIRST INCIDENCE (DAYS) | 330 465 330 | 372 409 622 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.111N P=0.459 P=0.134N | P=0.300N P=0.045N* P=0.334N |
|INCIDENTAL TUMOR | P=0.117N P=0.142 P=0.152N | P=0.378N P=0.041N* P=0.404N |
|LOGISTIC REGRESSION | P=0.083N P=0.199 P=0.140N | P=0.417N P=0.040N* P=0.338N |
|COCHRAN-ARMITAGE | P=0.107N | P=0.252N |
|FISHER EXACT | P=0.243 P=0.126N | P=0.043N* P=0.283N |
|=================================================================================================================================|
DATE: 09/05/94 EXPERIMENT: 05040 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- HYDROQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 50 MG/KG 100MG/KG | VEHICLE 50 MG/KG 100MG/KG |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 39/55 (71%) 46/54 (85%) 44/55 (80%) | 43/55 (78%) 42/55 (76%) 39/55 (71%) |
|ADJUSTED (b) | 77.8% 92.0% 87.9% | 85.9% 82.2% 81.2% |
|TERMINAL (d) | 22/33 (67%) 33/37 (89%) 30/36 (83%) | 30/37 (81%) 30/39 (77%) 27/36 (75%) |
|FIRST INCIDENCE (DAYS) | 330 441 330 | 372 409 548 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.382 P=0.346 P=0.405 | P=0.317N P=0.338N P=0.349N |
|INCIDENTAL TUMOR | P=0.152 P=0.050 * P=0.186 | P=0.410N P=0.426N P=0.451N |
|LOGISTIC REGRESSION | P=0.186 P=0.053 P=0.218 | P=0.325N P=0.438N P=0.368N |
|COCHRAN-ARMITAGE | P=0.148 | P=0.220N |
|FISHER EXACT | P=0.058 P=0.188 | P=0.500N P=0.256N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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