TDMS Study 05040-02 Pathology Tables
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
Facility: American Biogenics Corp.
Chemical CAS #: 000123319
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|
| 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + A A + + + +|
Amyloid Deposition | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A A + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Congestion | |
Eosinophilic Focus | X X |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Chronic | |
Inflammation, Focal, Granulomatous | |
Mixed Cell Focus | |
Necrosis | 2 |
Biliary Tract, Inflammation, Chronic | 2 |
Kupffer Cell, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + + +|
Inflammation, Chronic | 4 |
Inflammation, Suppurative | |
Fat, Hemorrhage, Focal | |
Fat, Necrosis, Focal | 4 2 4 4 4|
Fat, Lymphatic, Hemorrhage, Focal | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Subacute | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|
| 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic | |
Atrioventricular Valve, Inflammation,| |
Subacute | |
Atrium, Thrombosis | |
Epicardium, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 4 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + + + M + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + I + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 3 3 2 3 1 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicular Cell, Hyperplasia | 2 1 4 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Fibrosis | 4 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 4 |
Necrosis | |
Thrombosis | X |
Periovarian Tissue, Inflammation, | |
Chronic | 2 |
Periovarian Tissue, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Endometrium, Hemorrhage | |
Endometrium, Hyperplasia, Cystic | 2 4 3 3 2 2 3 4 3 2 2 2 3 3 2 4|
Endometrium, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|
| 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Deep Cervical, Hyperplasia, Plasma | |
Cell | 4 |
Inguinal, Hematopoietic Cell | |
Proliferation | 4 |
Mediastinal, Hematopoietic Cell | |
Proliferation | 4 |
Mediastinal, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + M + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Lymphoid, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid, Plasma Cell | |
Thrombosis | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 4|
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + M M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 |
Hyperplasia | 2 3 3 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 |
Joint, Tarsal, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 |
Cerebrum, Inflammation, Chronic, | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 6| 7| 4| 4| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 5| 3| 9| 3| 5| 0| 3| 3| 5| 8| 5| 3| 3| 3| 9| 6| 9| 3| 3| 3| 3|
| 5| 5| 6| 1| 7| 7| 3| 7| 7| 6| 6| 6| 2| 3| 7| 7| 5| 5| 1| 9| 5| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Focal | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage, Focal | |
Inflammation, Chronic | 3 |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Chronic | |
Nasolacrimal Duct, Foreign Body | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Glomerulosclerosis | |
Inflammation, Chronic | 1 1 2 2 1 2 1 1 2 1 1 2 2 1 |
Cortex, Metaplasia, Osseous | |
Cortex, Necrosis, Focal | |
Renal Tubule, Pigmentation, | |
Hemosiderin | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | |
Submucosa, Inflammation, Chronic | 1 1 1 2 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|
| 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M + + + + + + + A + + + + A|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + A|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X |
Congestion | 2 |
Eosinophilic Focus | X |
Fatty Change | 1 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 1 1 2 |
Inflammation, Focal, Granulomatous | |
Mixed Cell Focus | |
Necrosis | 1|
Biliary Tract, Inflammation, Chronic | |
Kupffer Cell, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
Fat, Hemorrhage, Focal | 3 |
Fat, Necrosis, Focal | 4 4 3 4 |
Fat, Lymphatic, Hemorrhage, Focal | |
Perivascular, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + M + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
Inflammation, Subacute | |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 1 2 2 1 3 1 1 2 1 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|
| 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Inflammation, Chronic | 3 |
Atrioventricular Valve, Inflammation,| |
Subacute | |
Atrium, Thrombosis | X |
Epicardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 |
Hyperplasia, Focal | 3 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + + + + + + M + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + M M + + M + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 3 2 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Follicular Cell, Hyperplasia | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X |
Fibrosis | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Necrosis | |
Thrombosis | |
Periovarian Tissue, Inflammation, | |
Chronic | 1 1 2 |
Periovarian Tissue, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Uterus | + + + + + + + M + + + + + + + + + + + +|
Hydrometra | 3 3 |
Endometrium, Hemorrhage | 3 |
Endometrium, Hyperplasia, Cystic | 2 3 2 2 4 1 4 2 4 3 4 2 |
Endometrium, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|
| 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Deep Cervical, Hyperplasia, Plasma | |
Cell | |
Inguinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Lymphoid, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + M + + + + + + + +|
Congestion | 4 |
Cyst | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid, Plasma Cell | |
Thrombosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 |
__________________________________________________________________________|
Thymus | + + + A M + M + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | |
Hyperplasia | 2 3 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 1 |
Joint, Tarsal, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 |
Cerebrum, Inflammation, Chronic, | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 2| 7| 6| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 5| 9| 3| 3| 5| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5|
| 7| 6| 5| 7| 3| 5| 7| 7| 7| 2| 6| 6| 5| 5| 7| 7| 6| 5| 7| 1| 6| 6| 5| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Focal | 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | |
Inflammation, Chronic | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + M|
Mucosa, Inflammation, Chronic | |
Nasolacrimal Duct, Foreign Body | |
__________________________________________________________________________|
Trachea | + + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 4 |
Glomerulosclerosis | 3 |
Inflammation, Chronic | 2 2 2 1 1 2 1 2 2 2 1 1 1 |
Cortex, Metaplasia, Osseous | |
Cortex, Necrosis, Focal | |
Renal Tubule, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + M + + + + + + + + + + + +|
Cytomegaly | 2 |
Submucosa, Inflammation, Chronic | 2 2 2 2 2 2 2 3 2 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4| | |
DAY ON TEST | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5| | |
| 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + + + + | 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + M + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + | 49 |
Amyloid Deposition | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + | 52 |
Peyer's Patch, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 55 |
Angiectasis | | 1 1.0|
Basophilic Focus | X | 2 |
Congestion | | 1 2.0|
Eosinophilic Focus | | 3 |
Fatty Change | 3 1 | 4 1.8|
Hematopoietic Cell Proliferation | 4 2 | 3 2.3|
Inflammation, Chronic | 2 1 | 5 1.4|
Inflammation, Focal, Granulomatous | 4 | 1 4.0|
Mixed Cell Focus | X | 1 |
Necrosis | 3 | 3 2.0|
Biliary Tract, Inflammation, Chronic | | 1 2.0|
Kupffer Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 19 |
Inflammation, Chronic | | 2 3.5|
Inflammation, Suppurative | 4 | 1 4.0|
Fat, Hemorrhage, Focal | | 1 3.0|
Fat, Necrosis, Focal | 4 3 | 11 3.6|
Fat, Lymphatic, Hemorrhage, Focal | 4 | 1 4.0|
Perivascular, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + | 54 |
Inflammation, Chronic | | 1 4.0|
Inflammation, Subacute | 4 | 1 4.0|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + M + + + + + + + + | 54 |
Inflammation, Chronic | 2 3 2 1 | 25 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4| | |
DAY ON TEST | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5| | |
| 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 53 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + | 55 |
Cardiomyopathy | | 1 1.0|
Inflammation, Chronic | | 1 3.0|
Atrioventricular Valve, Inflammation,| | |
Subacute | 4 | 1 4.0|
Atrium, Thrombosis | | 1 |
Epicardium, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + | 55 |
Degeneration, Focal | | 2 3.0|
Hyperplasia, Focal | | 3 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + M + + + | 51 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + M + + + + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + M + + + + M | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + I + + + + | 52 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 3 | 13 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + | 55 |
Inflammation, Chronic | 2 2 | 3 1.7|
Follicular Cell, Hyperplasia | 2 1 3 1 3 | 13 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + | 55 |
Cyst | X X X X | 12 |
Fibrosis | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4| | |
DAY ON TEST | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5| | |
| 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Thrombosis | | 1 |
Periovarian Tissue, Inflammation, | | |
Chronic | 2 | 5 1.6|
Periovarian Tissue, Inflammation, | | |
Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + | 54 |
Hydrometra | | 2 3.0|
Endometrium, Hemorrhage | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 4 4 3 3 3 3 3 4 2 | 37 2.9|
Endometrium, Inflammation, | | |
Suppurative | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 55 |
Axillary, Hyperplasia, Lymphoid | 4 | 1 4.0|
Deep Cervical, Hyperplasia, Plasma | | |
Cell | | 1 4.0|
Inguinal, Hematopoietic Cell | | |
Proliferation | | 1 4.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 4.0|
Mediastinal, Inflammation, | | |
Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 4 | 2 4.0|
Hyperplasia, Lymphoid, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + | 52 |
Congestion | | 1 4.0|
Cyst | X | 1 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Lymphoid, Plasma Cell | 4 | 1 4.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 55 |
Hematopoietic Cell Proliferation | 4 4 | 7 3.9|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + M + + M M | 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + + + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4| | |
DAY ON TEST | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5| | |
| 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | | 1 2.0|
Hyperplasia | 4 3 2 | 9 2.7|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + | 55 |
Ulcer | | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + | 55 |
Fibrous Osteodystrophy | | 5 1.0|
Joint, Tarsal, Hyperostosis | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 55 |
Mineralization | | 5 1.0|
Cerebrum, Inflammation, Chronic, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 55 |
Congestion | | 1 3.0|
Hemorrhage, Focal | 4 | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Perivascular, Inflammation, Chronic | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 54 |
Mucosa, Inflammation, Chronic | 2 | 1 2.0|
Nasolacrimal Duct, Foreign Body | 4 | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 55 |
Amyloid Deposition | | 2 4.0|
Glomerulosclerosis | | 1 3.0|
Inflammation, Chronic | 2 2 1 2 1 2 1 3 | 35 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 5| 5| 4| | |
DAY ON TEST | 3| 3| 3| 7| 6| 3| 3| 3| 3| 5| 3| 3| 9| 4| 5| | |
| 6| 6| 5| 6| 4| 7| 7| 6| 5| 7| 7| 6| 6| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cortex, Metaplasia, Osseous | 3 | 1 3.0|
Cortex, Necrosis, Focal | 4 | 1 4.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + | 53 |
Cytomegaly | | 1 2.0|
Submucosa, Inflammation, Chronic | 1 2 1 1 2 2 2 | 28 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|
| 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Gallbladder | + + + + |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
Colon, Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + |
__________________________________________________________________________|
Intestine Small | + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
Muscularis, Inflammation, Acute | |
Serosa, Ileum, Jejunum, Inflammation,| |
Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Basophilic Focus | X X X |
Cyst | |
Eosinophilic Focus | |
Fatty Change | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Necrosis, Focal | |
Fat, Necrosis, Focal | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + |
Inflammation, Chronic | 3 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 3 2 1 1 2 2 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
Erosion, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
Hemorrhage | |
Atrium, Thrombosis | X |
Coronary Artery, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|
| 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 2 |
Polyarteritis | |
Follicular Cell, Hyperplasia | 2 1 2 4 2 4 2 2 2 1 1 4 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + |
Angiectasis | 4 |
Cyst | X X X X X X X |
Hemorrhage | |
Artery, Periovarian Tissue, | |
Inflammation, Chronic | 4 |
Periovarian Tissue, Inflammation, | |
Chronic | 3 3 |
Periovarian Tissue, Necrosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + |
Inflammation, Chronic | |
Endometrium, Hyperplasia, Cystic | 3 4 3 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Hyperplasia, Plasma Cell | |
Axillary, Hyperplasia, Plasma Cell | |
Iliac, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hyperplasia, Lymphoid | 4 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|
| 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Spleen | + + + + |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + M + + M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + |
Abdominal, Subcutaneous Tissue, | |
Abscess | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Cerebrum, Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hyperplasia, Macrophage | |
__________________________________________________________________________|
Nose | + + + + |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 4| 4| 4| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 5| 5| 5| 0| 3| 3| 3| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 8| 5| 3| 3| 3| 5| 5|
| 6| 7| 7| 7| 9| 7| 7| 6| 5| 7| 0| 7| 6| 5| 1| 7| 7| 6| 3| 7| 5| 5| 5| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + |
Submucosa, Inflammation, Chronic | 3 |
Subserosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | + A + M + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + M + + |
Colon, Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + |
Muscularis, Inflammation, Acute | 3 |
Serosa, Ileum, Jejunum, Inflammation,| |
Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Basophilic Focus | X X X |
Cyst | X |
Eosinophilic Focus | X |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | 4|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic | 1 |
Necrosis | 3 2|
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | |
Necrosis, Focal | 4 |
Fat, Necrosis, Focal | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + |
Inflammation, Chronic | 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 2 2 2 1 2 2 1 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + M |
Erosion, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Hemorrhage | |
Atrium, Thrombosis | |
Coronary Artery, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + M + M |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + |
__________________________________________________________________________|
Pituitary Gland | + + + + M + M + + + M +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 |
Polyarteritis | 2 |
Follicular Cell, Hyperplasia | 3 2 2 2 2 3 2 2 4 1 3 1 2 3 2 2 2 2 1 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X |
Hemorrhage | 4|
Artery, Periovarian Tissue, | |
Inflammation, Chronic | |
Periovarian Tissue, Inflammation, | |
Chronic | 2 2 |
Periovarian Tissue, Necrosis | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + |
Inflammation, Chronic | |
Endometrium, Hyperplasia, Cystic | 4 2 3 3 3 3 2 3 4 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Hyperplasia, Plasma Cell | |
Axillary, Hyperplasia, Plasma Cell | |
Iliac, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hyperplasia, Lymphoid | 4 |
Renal, Hemorrhage | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Spleen | + + + M + + + + + + + + + |
Fibrosis | 4 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | 3 |
Pigmentation, Hemosiderin | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + |
Abdominal, Subcutaneous Tissue, | |
Abscess | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Cerebrum, Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Hyperplasia, Macrophage | 3 |
__________________________________________________________________________|
Nose | + + + + + + + |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 3| 3| 5| 3| 3| 3| 1| 1| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|
| 5| 5| 9| 1| 8| 5| 5| 5| 4| 7| 6| 6| 5| 7| 6| 7| 7| 6| 5| 8| 7| 6| 6| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
Submucosa, Inflammation, Chronic | 1 2 |
Subserosa, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4| | |
| 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 16 |
__________________________________________________________________________|____________|
Gallbladder | + + A M + | 12 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 13 |
Colon, Serosa, Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 15 |
Muscularis, Inflammation, Acute | | 1 3.0|
Serosa, Ileum, Jejunum, Inflammation,| | |
Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + | 14 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + | 55 |
Angiectasis | | 2 2.5|
Basophilic Focus | | 6 |
Cyst | | 1 |
Eosinophilic Focus | X X | 3 |
Fatty Change | | 2 2.5|
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic | 1 1 2 | 4 1.3|
Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + + + | 12 |
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
Necrosis, Focal | | 1 4.0|
Fat, Necrosis, Focal | 4 | 6 3.8|
__________________________________________________________________________|____________|
Pancreas | + + A + + | 16 |
Inflammation, Chronic | 3 | 3 2.7|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + M | 54 |
Inflammation, Chronic | 2 2 2 2 2 1 2 | 34 1.8|
__________________________________________________________________________|____________|
Stomach | + + A + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 16 |
Erosion, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4| | |
| 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 17 |
Hemorrhage | 3 | 1 3.0|
Atrium, Thrombosis | | 1 |
Coronary Artery, Inflammation, | | |
Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + M + | 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 13 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M M | 11 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 13 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M | 29 |
Pars Distalis, Angiectasis | | 2 2.0|
Pars Distalis, Hyperplasia, Focal | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + | 55 |
Inflammation, Chronic | | 4 2.3|
Polyarteritis | | 1 2.0|
Follicular Cell, Hyperplasia | 2 3 1 3 1 3 1 2 1 2 1 | 47 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | |
__________________________________________________________________________|____________|
Ovary | + + + + + M + M + + + + + | 53 |
Angiectasis | | 1 4.0|
Cyst | X X | 12 |
Hemorrhage | | 1 4.0|
Artery, Periovarian Tissue, | | |
Inflammation, Chronic | | 1 4.0|
Periovarian Tissue, Inflammation, | | |
Chronic | 2 | 5 2.4|
Periovarian Tissue, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + | 29 |
Inflammation, Chronic | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3 4 | 18 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4| | |
| 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 16 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 22 |
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Axillary, Hyperplasia, Plasma Cell | 4 | 1 4.0|
Iliac, Hematopoietic Cell | | |
Proliferation | 4 | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 4.0|
Renal, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 16 |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + | 17 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 2 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 22 |
Fibrosis | | 1 4.0|
Hematopoietic Cell Proliferation | 4 | 2 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation, Hemosiderin | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + M + M + | 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 20 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + | 16 |
Abdominal, Subcutaneous Tissue, | | |
Abscess | 4 | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 16 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 16 |
Cerebrum, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 8| 5| 4| 3| 3| 6| 0| 5| 3| 3| 3| 3| 4| | |
| 7| 7| 0| 7| 0| 7| 6| 0| 6| 7| 7| 6| 5| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 55 |
Inflammation, Chronic | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolus, Hyperplasia, Macrophage | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 16 |
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 16 |
Inflammation, Chronic | 2 2 | 8 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + | 15 |
Submucosa, Inflammation, Chronic | 2 | 4 2.0|
Subserosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|
| 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + A + M + + A + + + + M + + + M + + + |
Mucosa, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small | + + + A + + + + A + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + A + + + |
Amyloid Deposition | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + A + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Basophilic Focus | X |
Cyst | |
Eosinophilic Focus | X |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 1 1 |
Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + A + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + |
Inflammation, Chronic | 2 1 1 2 2 1 1 3 1 1 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Coronary Artery, Inflammation, | |
Chronic | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Diffuse | |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|
| 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + M + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + + M + + + M + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 2 4 2 3 2 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 3 2 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 2 3 1 3 2 1 3 3 1 2 3 4 3 1 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + A + + + + + + + + + + + + + + + + + |
Cyst | X X X X |
Periovarian Tissue, Inflammation, | |
Chronic | 2 2 2 |
Serosa, Hyperplasia, Papillary | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Hydrometra | 3 |
Endometrium, Hyperplasia, Cystic | 2 2 3 2 4 2 2 1 2 4 3 4 |
Myometrium, Hyperplasia | |
Submucosa, Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + M + + |
Hyperplasia, Plasma Cell | |
Axillary, Hyperplasia, Plasma Cell | 4 |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + M + + |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + M + + |
Congestion | |
Hyperplasia, Lymphoid | 4 |
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Hematopoietic Cell Proliferation | 4 4 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|
| 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + A + + + M + + + + A M + + |
Ectopic Parathyroid Gland | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + + + + + + |
Hyperplasia | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Ulcer | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
Fibrous Osteodystrophy | 1 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Atrophy | |
Hemorrhage, Focal | 2 |
Mineralization | 1 1 1 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Atelectasis | |
Congestion | 3 |
Inflammation, Chronic | 1 2 1 1 |
Metaplasia, Osseous | 2 |
Alveolus, Hyperplasia, Macrophage | 3 |
Artery, Hypertrophy | |
Artery, Capillary, Vein, Leukocytosis| |
Peribronchiolar, Inflammation, | |
Chronic | |
Perivascular, Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Conjunctiva, Retrobulbar, | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 1| 7| 5| 4| 4|
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 4| 2| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 4| 5| 5|
| 6| 6| 6| 0| 1| 7| 6| 4| 2| 7| 6| 6| 5| 5| 5| 7| 7| 5| 1| 7| 6| 6| 8| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | |
Inflammation, Chronic | |
Extraorbital, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | 4 |
Inflammation, Chronic | 1 2 2 3 1 2 2 2 4 2 2 1 2 3 |
Metaplasia, Focal, Osseous | 3 |
Nephropathy | |
Cortex, Fibrosis, Focal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + |
Muscularis, Submucosa, Inflammation | |
Submucosa, Inflammation, Chronic, | |
Hemorrhagic | |
Submucosa, Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 1 1 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|
| 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + |
Mucosa, Hyperplasia, Focal | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M M M M + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Basophilic Focus | X |
Cyst | X |
Eosinophilic Focus | |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 1 1 2 |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 2 1 3 1 2 3 2 2 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Coronary Artery, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Diffuse | 4 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal | 2 3 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|
| 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M M M + + + + + + + + + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + M + + + + + + + + |
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia, Focal | 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 4 2 3 2 3 4 4 3 3 1 1 3 3 3 2 3 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + |
Cyst | X X X X X X X X |
Periovarian Tissue, Inflammation, | |
Chronic | 3 |
Serosa, Hyperplasia, Papillary | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + |
Hydrometra | 4 |
Endometrium, Hyperplasia, Cystic | 3 3 3 2 3 4 3 2 4 2 3 2 2 3 |
Myometrium, Hyperplasia | |
Submucosa, Angiectasis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Plasma Cell | 4 |
Axillary, Hyperplasia, Plasma Cell | |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + M + + + + + + + M + + + + + + + |
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + |
Congestion | 3 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Hematopoietic Cell Proliferation | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|
| 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + M |
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + |
Hyperplasia | 1 1 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
Fibrous Osteodystrophy | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 3 |
Hemorrhage, Focal | |
Mineralization | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Atelectasis | |
Congestion | 3 3 |
Inflammation, Chronic | 2 |
Metaplasia, Osseous | |
Alveolus, Hyperplasia, Macrophage | 3 |
Artery, Hypertrophy | 3 |
Artery, Capillary, Vein, Leukocytosis| |
Peribronchiolar, Inflammation, | |
Chronic | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Conjunctiva, Retrobulbar, | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 0| 0| 0| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 5|
| 7| 7| 6| 6| 5| 5| 5| 5| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation | |
__________________________________________________________________________|
Harderian Gland | + + + + + |
__________________________________________________________________________|
Lacrimal Gland | + |
Inflammation, Chronic | 2 |
Extraorbital, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Inflammation, Chronic | 3 2 1 1 2 1 2 2 1 1 1 |
Metaplasia, Focal, Osseous | |
Nephropathy | 3 |
Cortex, Fibrosis, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + |
Muscularis, Submucosa, Inflammation | |
Submucosa, Inflammation, Chronic, | |
Hemorrhagic | 3 |
Submucosa, Inflammation, Chronic | 3 2 2 2 2 2 2 2 2 1 2 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8| | |
| 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + + + + + | 48 |
Mucosa, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + | 52 |
Amyloid Deposition | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 55 |
Amyloid Deposition | 4 | 1 4.0|
Basophilic Focus | X | 3 |
Cyst | | 1 |
Eosinophilic Focus | X | 2 |
Focal Cellular Change | X | 1 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Inflammation, Chronic | | 5 1.2|
Necrosis | 3 | 2 3.5|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 53 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 54 |
Inflammation, Chronic | 1 2 2 2 2 2 1 2 | 33 1.7|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 55 |
Inflammation, Chronic | 3 | 1 3.0|
Coronary Artery, Inflammation, | | |
Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8| | |
| 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 55 |
Degeneration, Diffuse | | 1 4.0|
Hematopoietic Cell Proliferation | 4 | 4 3.3|
Hyperplasia, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + M + + | 52 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + M + + + | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + | 52 |
Pars Distalis, Angiectasis | 2 4 4 | 4 2.8|
Pars Distalis, Hyperplasia, Focal | 2 2 | 13 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 55 |
Inflammation, Chronic | 2 2 2 | 9 2.1|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 3 2 3 3 3 3 1 4 2 2 | 45 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + | 54 |
Cyst | X X | 14 |
Periovarian Tissue, Inflammation, | | |
Chronic | | 4 2.3|
Serosa, Hyperplasia, Papillary | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + | 55 |
Hydrometra | | 2 3.5|
Endometrium, Hyperplasia, Cystic | 4 2 2 3 2 | 31 2.7|
Myometrium, Hyperplasia | 2 | 1 2.0|
Submucosa, Angiectasis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 54 |
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 54 |
Hyperplasia, Plasma Cell | | 1 4.0|
Axillary, Hyperplasia, Plasma Cell | | 1 4.0|
Mediastinal, Hyperplasia, Plasma Cell| 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8| | |
| 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + | 49 |
Hyperplasia, Lymphoid | | 1 4.0|
Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + | 52 |
Congestion | 4 | 2 3.5|
Hyperplasia, Lymphoid | | 2 3.5|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 55 |
Amyloid Deposition | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 4 4 | 4 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M | 47 |
Ectopic Parathyroid Gland | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 53 |
Hyperplasia | 2 | 5 1.6|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 55 |
Ulcer | 3 4 | 4 3.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 55 |
Fibrous Osteodystrophy | | 3 1.3|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 55 |
Atrophy | | 1 3.0|
Hemorrhage, Focal | | 1 2.0|
Mineralization | | 3 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 55 |
Atelectasis | 3 | 1 3.0|
Congestion | | 3 3.0|
Inflammation, Chronic | | 5 1.4|
Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 4| 3| | |
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 8| 5| 2| 0| 4| 5| 8| | |
| 7| 6| 6| 2| 7| 7| 7| 5| 6| 7| 9| 2| 1| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Hyperplasia, Macrophage | | 2 3.0|
Artery, Hypertrophy | | 1 3.0|
Artery, Capillary, Vein, Leukocytosis| X | 1 |
Peribronchiolar, Inflammation, | | |
Chronic | 2 | 1 2.0|
Perivascular, Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 55 |
Inflammation, Acute | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Conjunctiva, Retrobulbar, | | |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 7 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 2 |
Inflammation, Chronic | | 1 2.0|
Extraorbital, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 55 |
Amyloid Deposition | 4 | 2 4.0|
Inflammation, Chronic | 2 1 2 1 2 2 1 2 2 | 34 1.8|
Metaplasia, Focal, Osseous | | 1 3.0|
Nephropathy | | 1 3.0|
Cortex, Fibrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + | 54 |
Muscularis, Submucosa, Inflammation | 2 | 1 2.0|
Submucosa, Inflammation, Chronic, | | |
Hemorrhagic | | 1 3.0|
Submucosa, Inflammation, Chronic | 1 1 2 2 2 | 33 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|
| 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Cyst | X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | |
Infarct | |
Mixed Cell Focus | X X |
Necrosis, Focal | 2 |
Necrosis | |
Syncytial Alteration | 1 1 1 1|
Thrombosis | |
__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | |
Inflammation, Acute | |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hemorrhage, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 |
Inflammation, Chronic | 2 1 1 2 1 1 2 2 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Tooth | + + + |
Peridontal Tissue, Inflammation, | |
Suppurative | |
Peridontal Tissue, Pulp, Abscess | 4 |
Pulp, Abscess | 4 |
Pulp, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|
| 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 4 3 |
Ectopic Tissue | X |
Hyperplasia, Focal | 3 3 2 2 1 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M + + M + + + + + + M + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst, Multiple | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 4 4|
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 4 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|
| 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
Axillary, Hyperplasia, Lymphoid | 4 |
Axillary, Hyperplasia, Plasma Cell | |
Iliac, Hyperplasia, Lymphoid | 4 |
Iliac, Hyperplasia, Plasma Cell | |
Inguinal, Cyst | |
Lumbar, Congestion | 3 |
Lumbar, Hyperplasia, Lymphoid | 4 |
Mediastinal, Hyperplasia | 3 |
Pancreatic, Congestion | |
Popliteal, Hyperplasia, Lymphoid | 4 |
Popliteal, Hyperplasia, Plasma Cell | |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + M + M|
Congestion | 2 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 3 4 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 4 4 |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 4 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + M + M + M + M M + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Atrophy | |
Inflammation, Chronic | 3 |
Ulcer | 4 1 4 |
Artery, Subcutaneous Tissue, | |
Inflammation, Chronic | 4 |
Dermis, Fibrosis | 4 |
Dermis, Inflammation, Chronic | 2 |
Prepuce, Inflammation, Chronic | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|
| 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Inflammation, | |
Subacute | 3 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | 4|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | X X X |
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Alveolus, Hyperplasia, Macrophage | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Turbinate, Inflammation, | |
Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X|
Cyst, Multiple | |
Glomerulosclerosis | 3 3 4 |
Inflammation, Chronic | 1 1 2 3 2 1 2 2 2 3 3 2 2 1 3 2 1 2 1 |
Inflammation, Suppurative | |
Nephropathy | |
Cortex, Infarct | 4 |
__________________________________________________________________________|
Urethra | +|
Distal, Inflammation, Chronic | |
Proximal, Inflammation, Suppurative | 4|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 4| 3| 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 2| 9| 8| 2| 3| 3| 2| 5| 4| 3| 3| 9| 9| 0| 3| 2| 2| 8| 5| 3| 2| 2| 5| 0|
| 0| 9| 1| 3| 1| 0| 0| 9| 8| 7| 1| 0| 8| 4| 5| 0| 9| 9| 2| 5| 1| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + +|
Perivascular, Inflammation, Chronic | 2 |
Submucosa, Inflammation, Chronic | 1 2 2 2 3 1 |
Wall, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|
| 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + A + + A + + + + + + + + + + M |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + A + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Basophilic Focus | |
Cyst | |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | |
Infarct | |
Mixed Cell Focus | |
Necrosis, Focal | |
Necrosis | 4 |
Syncytial Alteration | 1 |
Thrombosis | |
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | 3 |
Inflammation, Acute | 4 |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Fibrosis, Focal | 3 |
Hemorrhage, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Degeneration, Chronic | |
Inflammation, Chronic | 1 2 2 2 2 2 1 2 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
Ulcer | |
__________________________________________________________________________|
Tooth | + + + |
Peridontal Tissue, Inflammation, | |
Suppurative | 4 3 |
Peridontal Tissue, Pulp, Abscess | |
Pulp, Abscess | 3 |
Pulp, Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|
| 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
Subcapsular, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Degeneration, Focal | 2 |
Ectopic Tissue | |
Hyperplasia, Focal | 4 2 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M M + + + + M M |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
Follicle, Cyst, Multiple | X |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Inflammation, Chronic | 3 4 3 4 |
Inflammation, Suppurative | 4 4 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 2 2 4 |
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + |
Dilatation | |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + |
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|
| 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Plasma Cell | |
Axillary, Hyperplasia, Lymphoid | |
Axillary, Hyperplasia, Plasma Cell | |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | |
Inguinal, Cyst | X |
Lumbar, Congestion | |
Lumbar, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | |
Pancreatic, Congestion | 4 |
Popliteal, Hyperplasia, Lymphoid | |
Popliteal, Hyperplasia, Plasma Cell | |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + |
Congestion | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + |
Congestion | 4 4 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 4 4 4 4 |
__________________________________________________________________________|
Thymus | + + + M + + M M + M + + + + + M + M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M + M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Acanthosis | 3 |
Atrophy | 3 |
Inflammation, Chronic | |
Ulcer | 2 4 |
Artery, Subcutaneous Tissue, | |
Inflammation, Chronic | |
Dermis, Fibrosis | |
Dermis, Inflammation, Chronic | |
Prepuce, Inflammation, Chronic | 4 |
Subcutaneous Tissue, Edema | 4 |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|
| 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Inflammation, | |
Subacute | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
Joint, Tarsal, Hyperostosis | X X X X X X |
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
Mineralization | 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Alveolus, Hyperplasia, Macrophage | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Lumen, Turbinate, Inflammation, | |
Suppurative | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Calculus Micro Observation Only | X |
Cyst, Multiple | |
Glomerulosclerosis | |
Inflammation, Chronic | 1 2 1 1 1 1 2 1 2 2 2 2 |
Inflammation, Suppurative | 4 |
Nephropathy | 4 |
Cortex, Infarct | |
__________________________________________________________________________|
Urethra | + |
Distal, Inflammation, Chronic | 3 |
Proximal, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 8| 5| 5| 2| 2| 2| 5| 5| 3| 2| 0| 3| 5| 3| 3| 2| 8| 5|
| 1| 0| 9| 0| 8| 1| 0| 4| 8| 8| 9| 9| 9| 8| 8| 1| 9| 1| 5| 8| 1| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
Perivascular, Inflammation, Chronic | |
Submucosa, Inflammation, Chronic | 1 1 1 1 1 4 |
Wall, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3| | |
DAY ON TEST | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3| | |
| 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Gallbladder | + + A + M + + + M + + + A A | 44 |
__________________________________________________________________________|____________|
Intestine Large | + + A A + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + A + | 48 |
Amyloid Deposition | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 55 |
Basophilic Focus | | 2 |
Cyst | | 1 |
Eosinophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Infarct | 4 | 1 4.0|
Mixed Cell Focus | | 2 |
Necrosis, Focal | | 1 2.0|
Necrosis | 4 4 4 | 4 4.0|
Syncytial Alteration | | 5 1.0|
Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Hemorrhage | | 1 3.0|
Inflammation, Acute | | 1 4.0|
Fat, Necrosis, Focal | 4 | 3 4.0|
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + + + + + | 54 |
Fibrosis, Focal | | 1 3.0|
Hemorrhage, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 55 |
Degeneration, Chronic | | 1 2.0|
Inflammation, Chronic | 1 2 1 1 1 2 2 | 30 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 55 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 6 |
Peridontal Tissue, Inflammation, | | |
Suppurative | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3| | |
DAY ON TEST | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3| | |
| 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Peridontal Tissue, Pulp, Abscess | | 1 4.0|
Pulp, Abscess | | 2 3.5|
Pulp, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 55 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 55 |
Subcapsular, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 55 |
Degeneration, Focal | 2 3 | 5 2.8|
Ectopic Tissue | | 1 |
Hyperplasia, Focal | 3 3 | 9 2.6|
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 54 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + + + M + + + | 53 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + M + + + M + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M | 50 |
Pars Distalis, Hyperplasia, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 55 |
Follicle, Cyst, Multiple | | 1 |
Follicular Cell, Hyperplasia | 1 2 | 5 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + M + + + + + + + | 54 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 11 |
Inflammation, Chronic | | 5 3.2|
Inflammation, Suppurative | 4 | 5 4.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3| | |
DAY ON TEST | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3| | |
| 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + | 55 |
Inflammation, Chronic | 4 | 6 2.5|
Inflammation, Chronic Active | 3 | 3 3.3|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + | 55 |
Dilatation | | 1 4.0|
Inflammation, Chronic | 4 | 2 3.5|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + | 55 |
Atrophy | | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 55 |
Hyperplasia, Plasma Cell | 4 | 1 4.0|
Axillary, Hyperplasia, Lymphoid | | 1 4.0|
Axillary, Hyperplasia, Plasma Cell | 4 | 1 4.0|
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Iliac, Hyperplasia, Plasma Cell | 4 | 1 4.0|
Inguinal, Cyst | | 1 |
Lumbar, Congestion | | 1 3.0|
Lumbar, Hyperplasia, Lymphoid | | 1 4.0|
Mediastinal, Hyperplasia | | 1 3.0|
Pancreatic, Congestion | | 1 4.0|
Popliteal, Hyperplasia, Lymphoid | | 1 4.0|
Popliteal, Hyperplasia, Plasma Cell | 4 | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 52 |
Congestion | 3 | 2 2.5|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + | 54 |
Congestion | 4 4 4 3 3 | 11 3.6|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hyperplasia, Lymphoid | 4 | 3 4.0|
Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 55 |
Hematopoietic Cell Proliferation | 4 4 4 | 10 4.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + M + + + M + | 39 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3| | |
DAY ON TEST | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3| | |
| 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 55 |
Acanthosis | | 2 3.0|
Atrophy | 2 | 2 2.5|
Inflammation, Chronic | | 1 3.0|
Ulcer | | 5 3.0|
Artery, Subcutaneous Tissue, | | |
Inflammation, Chronic | | 1 4.0|
Dermis, Fibrosis | | 1 4.0|
Dermis, Inflammation, Chronic | | 1 2.0|
Prepuce, Inflammation, Chronic | 2 | 2 3.0|
Subcutaneous Tissue, Edema | 4 | 2 4.0|
Subcutaneous Tissue, Hemorrhage | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Subacute | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 54 |
Joint, Tarsal, Hyperostosis | X | 10 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Abdominal, Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 55 |
Mineralization | | 2 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 55 |
Alveolus, Hyperplasia, Macrophage | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 55 |
Lumen, Turbinate, Inflammation, | | |
Suppurative | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 6| 3| | |
DAY ON TEST | 3| 0| 4| 4| 5| 3| 3| 2| 6| 3| 3| 3| 2| 0| 3| | |
| 0| 9| 9| 8| 8| 1| 0| 9| 2| 7| 1| 0| 9| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 55 |
Calculus Micro Observation Only | | 2 |
Cyst, Multiple | X | 1 |
Glomerulosclerosis | | 3 3.3|
Inflammation, Chronic | 2 2 2 1 3 2 2 4 3 2 2 2 1 1 | 45 1.8|
Inflammation, Suppurative | | 1 4.0|
Nephropathy | | 1 4.0|
Cortex, Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Urethra | + | 3 |
Distal, Inflammation, Chronic | | 1 3.0|
Proximal, Inflammation, Suppurative | 4 | 2 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 54 |
Perivascular, Inflammation, Chronic | 3 | 2 2.5|
Submucosa, Inflammation, Chronic | 2 1 1 | 15 1.6|
Wall, Inflammation, Subacute | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 4| 4| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 5| 5| 6| 3| 3| 3| 3| 5| 3| 3| 5| 5| 1| 3| 2| 8| 4| 6| 3| 3| 3| 3| 2|
| 2| 1| 8| 8| 8| 1| 1| 0| 0| 8| 1| 0| 8| 8| 8| 1| 9| 8| 8| 5| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
Diverticulum | |
Mucosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Anisokaryosis | 2 |
Autolysis | |
Basophilic Focus | X |
Clear Cell Focus | |
Cyst | 4 |
Eosinophilic Focus | X X |
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic | |
Necrosis | |
Syncytial Alteration | 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Pancreas | + + + A + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
Inflammation, Chronic | 1 2 |
__________________________________________________________________________|
Stomach | + + + A + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
__________________________________________________________________________|
Tooth | + |
Pulp, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 4| 4| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 5| 5| 6| 3| 3| 3| 3| 5| 3| 3| 5| 5| 1| 3| 2| 8| 4| 6| 3| 3| 3| 3| 2|
| 2| 1| 8| 8| 8| 1| 1| 0| 0| 8| 1| 0| 8| 8| 8| 1| 9| 8| 8| 5| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Focal | 3 |
Hyperplasia, Focal | |
Spindle Cell, Subcapsular, | |
Proliferation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + |
Pars Distalis, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
Follicular Cell, Hyperplasia | 2 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 4|
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + |
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid, Plasma Cell | 4 |
Hyperplasia, Plasma Cell | |
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hyperplasia | |
Iliac, Hyperplasia, Plasma Cell | 4 |
Inguinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 4| 4| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 5| 5| 6| 3| 3| 3| 3| 5| 3| 3| 5| 5| 1| 3| 2| 8| 4| 6| 3| 3| 3| 3| 2|
| 2| 1| 8| 8| 8| 1| 1| 0| 0| 8| 1| 0| 8| 8| 8| 1| 9| 8| 8| 5| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 4 4 3|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 3 4 4 3|
__________________________________________________________________________|
Thymus | + M + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + |
Acanthosis | 3 3 |
Atrophy | 3 |
Inflammation, Chronic | |
Ulcer | 4 4 |
Dermis, Inflammation, Chronic | 3 |
Prepuce, Inflammation, Suppurative | 3 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + +|
Hyperostosis | |
Joint, Tarsal, Hyperostosis | X X X X|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + |
Congestion | 4 3 3 |
Alveolar Epithelium, Hyperplasia, | |
Atypical | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Hyperplasia, Macrophage | |
Vein, Leukocytosis | |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + A + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 3| 7| 7| 7| 7| 4| 7| 7| 4| 4| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 0| 5| 5| 6| 3| 3| 3| 3| 5| 3| 3| 5| 5| 1| 3| 2| 8| 4| 6| 3| 3| 3| 3| 2|
| 2| 1| 8| 8| 8| 1| 1| 0| 0| 8| 1| 0| 8| 8| 8| 1| 9| 8| 8| 5| 0| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Cytoplasmic Alteration | |
Inflammation, Chronic | 1 1 1 1 2 |
Inflammation, Suppurative | |
Nephropathy | |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + |
Submucosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 0| 4|
DAY ON TEST | 3| 2| 2| 9| 5| 2| 2| 8| 5| 7| 2| 2| 2| 2| 5| 3| 3| 3| 3| 2| 3| 5| 4| 1| 5|
| 1| 9| 9| 1| 6| 9| 9| 4| 8| 9| 9| 9| 9| 9| 4| 1| 1| 1| 0| 9| 0| 2| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | M A + + A + M A |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + A + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + A |
Diverticulum | |
Mucosa, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Anisokaryosis | 1 |
Autolysis | 4 |
Basophilic Focus | X X X |
Clear Cell Focus | |
Cyst | |
Eosinophilic Focus | X |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 2 |
Necrosis | |
Syncytial Alteration | 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + M |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
Inflammation, Chronic | 2 2 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
__________________________________________________________________________|
Tooth | |
Pulp, Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + M + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 0| 4|
DAY ON TEST | 3| 2| 2| 9| 5| 2| 2| 8| 5| 7| 2| 2| 2| 2| 5| 3| 3| 3| 3| 2| 3| 5| 4| 1| 5|
| 1| 9| 9| 1| 6| 9| 9| 4| 8| 9| 9| 9| 9| 9| 4| 1| 1| 1| 0| 9| 0| 2| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Degeneration, Focal | |
Hyperplasia, Focal | 1 |
Spindle Cell, Subcapsular, | |
Proliferation | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 4 4 4 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Congestion | |
Hyperplasia, Lymphoid, Plasma Cell | |
Hyperplasia, Plasma Cell | 3 |
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hyperplasia | 3 |
Iliac, Hyperplasia, Plasma Cell | |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + A |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 0| 4|
DAY ON TEST | 3| 2| 2| 9| 5| 2| 2| 8| 5| 7| 2| 2| 2| 2| 5| 3| 3| 3| 3| 2| 3| 5| 4| 1| 5|
| 1| 9| 9| 1| 6| 9| 9| 4| 8| 9| 9| 9| 9| 9| 4| 1| 1| 1| 0| 9| 0| 2| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 4 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A |
Hematopoietic Cell Proliferation | 4 3 4 4 4 4 |
__________________________________________________________________________|
Thymus | M + M M + M M M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + |
Acanthosis | 4 |
Atrophy | 3 3 |
Inflammation, Chronic | |
Ulcer | 4 4 4 |
Dermis, Inflammation, Chronic | |
Prepuce, Inflammation, Suppurative | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
Hyperostosis | X X X X |
Joint, Tarsal, Hyperostosis | X X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + |
Congestion | |
Alveolar Epithelium, Hyperplasia, | |
Atypical | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hyperplasia, Macrophage | 4 |
Vein, Leukocytosis | |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 0| 4|
DAY ON TEST | 3| 2| 2| 9| 5| 2| 2| 8| 5| 7| 2| 2| 2| 2| 5| 3| 3| 3| 3| 2| 3| 5| 4| 1| 5|
| 1| 9| 9| 1| 6| 9| 9| 4| 8| 9| 9| 9| 9| 9| 4| 1| 1| 1| 0| 9| 0| 2| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Cytoplasmic Alteration | |
Inflammation, Chronic | 3 1 1 1 |
Inflammation, Suppurative | 4 |
Nephropathy | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
Submucosa, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| | |
DAY ON TEST | 3| 2| 5| 5| 5| 3| 3| 3| 2| 5| 3| 3| 4| 3| 9| | |
| 0| 9| 4| 8| 8| 1| 0| 0| 9| 8| 1| 0| 1| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 17 |
__________________________________________________________________________|____________|
Gallbladder | + A | 11 |
__________________________________________________________________________|____________|
Intestine Large | + A + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 15 |
__________________________________________________________________________|____________|
Intestine Small | + + A + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 13 |
Diverticulum | 3 | 1 3.0|
Mucosa, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 54 |
Anisokaryosis | | 2 1.5|
Autolysis | | 1 4.0|
Basophilic Focus | X | 5 |
Clear Cell Focus | X X | 2 |
Cyst | | 1 4.0|
Eosinophilic Focus | | 3 |
Focal Cellular Change | | 1 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Necrosis | 3 3 | 2 3.0|
Syncytial Alteration | | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + | 15 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 16 |
Inflammation, Chronic | 2 | 8 1.6|
__________________________________________________________________________|____________|
Stomach | + A + | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 15 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 15 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Pulp, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| | |
DAY ON TEST | 3| 2| 5| 5| 5| 3| 3| 3| 2| 5| 3| 3| 4| 3| 9| | |
| 0| 9| 4| 8| 8| 1| 0| 0| 9| 8| 1| 0| 1| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 52 |
Degeneration, Focal | | 1 3.0|
Hyperplasia, Focal | 3 | 2 2.0|
Spindle Cell, Subcapsular, | | |
Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 52 |
Hyperplasia, Focal | | 3 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 15 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + | 14 |
Pars Distalis, Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 53 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Follicular Cell, Hyperplasia | 1 | 15 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + | 17 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 9 |
Inflammation, Chronic | 3 | 3 3.3|
Inflammation, Suppurative | 4 4 | 6 4.0|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + | 17 |
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 17 |
__________________________________________________________________________|____________|
Testes | + + + | 18 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 17 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 29 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| | |
DAY ON TEST | 3| 2| 5| 5| 5| 3| 3| 3| 2| 5| 3| 3| 4| 3| 9| | |
| 0| 9| 4| 8| 8| 1| 0| 0| 9| 8| 1| 0| 1| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | 4 | 1 4.0|
Hyperplasia, Lymphoid, Plasma Cell | | 1 4.0|
Hyperplasia, Plasma Cell | | 1 3.0|
Iliac, Hematopoietic Cell | | |
Proliferation | 4 | 1 4.0|
Iliac, Hyperplasia | | 1 3.0|
Iliac, Hyperplasia, Plasma Cell | | 1 4.0|
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 17 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 23 |
Congestion | 3 4 | 6 3.7|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 52 |
Hematopoietic Cell Proliferation | 4 4 | 14 3.7|
__________________________________________________________________________|____________|
Thymus | + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + | 33 |
Acanthosis | | 3 3.3|
Atrophy | | 3 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Ulcer | 4 | 6 4.0|
Dermis, Inflammation, Chronic | | 1 3.0|
Prepuce, Inflammation, Suppurative | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 32 |
Hyperostosis | X | 5 |
Joint, Tarsal, Hyperostosis | X | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 17 |
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 31 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| | |
DAY ON TEST | 3| 2| 5| 5| 5| 3| 3| 3| 2| 5| 3| 3| 4| 3| 9| | |
| 0| 9| 4| 8| 8| 1| 0| 0| 9| 8| 1| 0| 1| 0| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Congestion | 3 | 4 3.3|
Alveolar Epithelium, Hyperplasia, | | |
Atypical | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Hyperplasia, Macrophage | | 1 4.0|
Vein, Leukocytosis | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + | 17 |
__________________________________________________________________________|____________|
Trachea | + + + | 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 17 |
Cytoplasmic Alteration | 2 | 1 2.0|
Inflammation, Chronic | 2 1 | 11 1.4|
Inflammation, Suppurative | | 1 4.0|
Nephropathy | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 15 |
Submucosa, Inflammation, Chronic | 1 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 4| 3|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 2| 2| 5| 3| 3| 3| 2| 2| 3| 3| 2| 2| 5| 8| 3| 8| 5| 3|
| 0| 0| 4| 3| 8| 1| 0| 9| 5| 8| 1| 0| 0| 6| 9| 1| 0| 9| 9| 8| 1| 1| 0| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + A + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + A + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + A + + + + + + + A +|
Mucosa, Necrosis | 4 |
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + A + + + + + + A +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Anisokaryosis | 1 1 1 |
Basophilic Focus | X X X X |
Cyst | |
Cytomegaly | 1 2 1 |
Eosinophilic Focus | X X |
Fatty Change | 2 |
Hyperplasia, Re Cell | |
Infarct | 4 |
Inflammation, Chronic | 3 |
Mixed Cell Focus | X |
Necrosis | |
Syncytial Alteration | 1 2 2 3 1 2 1 1 1 1 1 |
Centrilobular, Degeneration, | |
Ballooning | 3 |
Sinusoid, Dilatation, Focal | |
__________________________________________________________________________|
Mesentery | + + + +|
Inflammation, Acute | 4 |
Inflammation, Chronic | |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Chronic | 1 |
Acinus, Vacuolization Cytoplasmic | |
Serosa, Inflammation, Acute | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Concretion, Chronic | 2 |
Inflammation, Chronic | 2 1 2 1 1 2 2 1 2 1 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 4| 3|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 2| 2| 5| 3| 3| 3| 2| 2| 3| 3| 2| 2| 5| 8| 3| 8| 5| 3|
| 0| 0| 4| 3| 8| 1| 0| 9| 5| 8| 1| 0| 0| 6| 9| 1| 0| 9| 9| 8| 1| 1| 0| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation, | |
Suppurative | 2 |
Pulp, Abscess | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Atrium Left, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 1 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Follicle, Inflammation, Acute | 2 |
Follicular Cell, Hyperplasia | 1 2 2 3 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 3 |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 4| 3|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 2| 2| 5| 3| 3| 3| 2| 2| 3| 3| 2| 2| 5| 8| 3| 8| 5| 3|
| 0| 0| 4| 3| 8| 1| 0| 9| 5| 8| 1| 0| 0| 6| 9| 1| 0| 9| 9| 8| 1| 1| 0| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 1 |
Serosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Germinal Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Acute | 4 |
Axillary, Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 4 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + M + M + + + M + + + + +|
Congestion | 3 4 4 4 3 4 4 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + A + + + + + + + + +|
Amyloid Deposition | |
Hematopoietic Cell Proliferation | 4 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + M M|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Alopecia | X |
Atrophy | 3 |
Inflammation, Chronic | 4 |
Ulcer | 4 4 2 4 4 4 |
Dermis, Inflammation, Chronic | 3 |
Dermis, Dorsal, Atrophy | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Tail, Dermis, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 4| 3|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 2| 2| 5| 3| 3| 3| 2| 2| 3| 3| 2| 2| 5| 8| 3| 8| 5| 3|
| 0| 0| 4| 3| 8| 1| 0| 9| 5| 8| 1| 0| 0| 6| 9| 1| 0| 9| 9| 8| 1| 1| 0| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 |
__________________________________________________________________________|
Spinal Cord | + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hyperplasia, Macrophage | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Lumen, Turbinate, Inflammation, | |
Suppurative | |
Mucosa, Inflammation, Chronic | |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Lacrimal Gland | |
Extraorbital, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Glomerulosclerosis | 4 |
Inflammation, Chronic | 2 2 2 2 1 2 3 2 1 2 1 3 2 2 |
Nephropathy | 4 |
Renal Tubule, Mineralization | |
__________________________________________________________________________|
Urethra | |
Distal, Concretion | |
Distal, Inflammation, Suppurative | |
Proximal, Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Hemorrhage | |
Submucosa, Inflammation, Chronic | 1 1 3 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 5| 4| 5| 5| 3| 3| 3| 9| 5| 3| 3| 2| 5| 3| 3| 2| 4| 5| 5|
| 1| 0| 9| 9| 3| 0| 7| 2| 8| 8| 1| 1| 0| 7| 8| 1| 0| 9| 5| 5| 0| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + A + M + + + + + + + + M M + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + A + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A A + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + A + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + A + + + + + + + A + + + + |
Mucosa, Necrosis | |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + A + + + + + + + A + + + + |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Anisokaryosis | 1 1 1 1 |
Basophilic Focus | X X X X |
Cyst | |
Cytomegaly | |
Eosinophilic Focus | X |
Fatty Change | 2 |
Hyperplasia, Re Cell | |
Infarct | |
Inflammation, Chronic | |
Mixed Cell Focus | |
Necrosis | 4 4 |
Syncytial Alteration | 1 2 2 1 2 1 2 2 |
Centrilobular, Degeneration, | |
Ballooning | |
Sinusoid, Dilatation, Focal | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Fat, Inflammation, Chronic | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 |
Acinus, Vacuolization Cytoplasmic | 3 |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Concretion, Chronic | |
Inflammation, Chronic | 1 2 2 2 1 2 2 2 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 5| 4| 5| 5| 3| 3| 3| 9| 5| 3| 3| 2| 5| 3| 3| 2| 4| 5| 5|
| 1| 0| 9| 9| 3| 0| 7| 2| 8| 8| 1| 1| 0| 7| 8| 1| 0| 9| 5| 5| 0| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + |
Acanthosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Ulcer | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Suppurative | |
Pulp, Abscess | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | |
Atrium Left, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 1 2 2 1 |
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + M + + + M + + M + |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Hyperplasia, Focal | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + |
Inflammation, Chronic | 1 |
Follicle, Inflammation, Acute | |
Follicular Cell, Hyperplasia | 2 1 1 3 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 4 4 4 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 5| 4| 5| 5| 3| 3| 3| 9| 5| 3| 3| 2| 5| 3| 3| 2| 4| 5| 5|
| 1| 0| 9| 9| 3| 0| 7| 2| 8| 8| 1| 1| 0| 7| 8| 1| 0| 9| 5| 5| 0| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 1 2 1 1 |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Atrophy | |
Germinal Epithelium, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Axillary, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + M + + + + + + + + + + + |
Hyperplasia, Plasma Cell | 4 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Congestion | 4 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Thymus | + + + + M + M M + + + M + + + + + + M + |
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M + M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Alopecia | |
Atrophy | |
Inflammation, Chronic | |
Ulcer | 4 3 3 |
Dermis, Inflammation, Chronic | 2 |
Dermis, Dorsal, Atrophy | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Tail, Dermis, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Joint, Tarsal, Hyperostosis | X X X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 6| 6| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 5| 4| 5| 5| 3| 3| 3| 9| 5| 3| 3| 2| 5| 3| 3| 2| 4| 5| 5|
| 1| 0| 9| 9| 3| 0| 7| 2| 8| 8| 1| 1| 0| 7| 8| 1| 0| 9| 5| 5| 0| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Mineralization | 1 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hyperplasia, Macrophage | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Lumen, Turbinate, Inflammation, | |
Suppurative | 3 |
Mucosa, Inflammation, Chronic | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Lacrimal Gland | + |
Extraorbital, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Glomerulosclerosis | |
Inflammation, Chronic | 2 2 1 2 2 3 2 1 2 2 1 2 2 3 1 2 2 1 2 |
Nephropathy | |
Renal Tubule, Mineralization | 2 |
__________________________________________________________________________|
Urethra | + + |
Distal, Concretion | 4 |
Distal, Inflammation, Suppurative | 2 |
Proximal, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Muscularis, Hemorrhage | |
Submucosa, Inflammation, Chronic | 2 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8| | |
| 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + + + M + | 48 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + M | 47 |
Mucosa, Necrosis | | 1 4.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + M + + + + + A | 45 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 55 |
Amyloid Deposition | 4 | 1 4.0|
Anisokaryosis | 1 1 2 2 1 | 12 1.2|
Basophilic Focus | X X X | 11 |
Cyst | X | 1 |
Cytomegaly | | 3 1.3|
Eosinophilic Focus | X | 4 |
Fatty Change | 1 | 3 1.7|
Hyperplasia, Re Cell | 2 | 1 2.0|
Infarct | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Mixed Cell Focus | | 1 |
Necrosis | | 2 4.0|
Syncytial Alteration | 1 1 3 1 2 1 | 25 1.5|
Centrilobular, Degeneration, | | |
Ballooning | | 1 3.0|
Sinusoid, Dilatation, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
Fat, Inflammation, Chronic | | 1 3.0|
Fat, Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + | 53 |
Inflammation, Chronic | | 2 1.0|
Acinus, Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8| | |
| 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Serosa, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 55 |
Concretion, Chronic | | 1 2.0|
Inflammation, Chronic | 1 2 1 2 2 2 2 2 | 31 1.6|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + M + + + + | 53 |
Acanthosis | | 1 4.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 55 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 2.0|
Pulp, Abscess | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 55 |
Cardiomyopathy | 2 | 1 2.0|
Atrium Left, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + M + + + + | 54 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + | 54 |
Hyperplasia, Focal | 2 | 6 1.8|
Hypertrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + | 54 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + + + M + + M + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + M + + + + | 50 |
Pars Distalis, Hyperplasia, Focal | | 5 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 54 |
Inflammation, Chronic | | 2 1.5|
Follicle, Inflammation, Acute | | 1 2.0|
Follicular Cell, Hyperplasia | 1 1 3 2 | 19 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8| | |
| 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + | 54 |
Inflammation, Chronic | 2 | 3 2.7|
__________________________________________________________________________|____________|
Preputial Gland | + | 7 |
Inflammation, Chronic | | 2 2.5|
Inflammation, Suppurative | 4 | 4 4.0|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + | 55 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 2 2 1 1 | 9 1.3|
Serosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + | 55 |
Serosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + | 55 |
Atrophy | | 1 4.0|
Germinal Epithelium, Degeneration | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 55 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Acute | | 1 4.0|
Axillary, Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 51 |
Hyperplasia, Plasma Cell | 4 | 5 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + | 50 |
Congestion | 3 4 | 10 3.7|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 54 |
Amyloid Deposition | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 4 3 4 4 | 6 3.8|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + + M M M | 42 |
Amyloid Deposition | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8| | |
| 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Acanthosis | 3 | 2 3.0|
Alopecia | | 1 |
Atrophy | | 1 3.0|
Inflammation, Chronic | 3 | 2 3.5|
Ulcer | 4 4 4 4 4 | 15 3.7|
Dermis, Inflammation, Chronic | | 2 2.5|
Dermis, Dorsal, Atrophy | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 4 | 1 4.0|
Tail, Dermis, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 55 |
Joint, Tarsal, Hyperostosis | X X | 7 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 55 |
Mineralization | | 3 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 55 |
Hemorrhage | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Alveolus, Hyperplasia, Macrophage | 3 | 2 3.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 55 |
Lumen, Turbinate, Inflammation, | | |
Suppurative | | 1 3.0|
Mucosa, Inflammation, Chronic | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 7 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Extraorbital, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05040-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 10:16:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 9| 8| 6| 7| 3| 3| 3| 5| 3| 3| 3| 3| 8| | |
| 1| 9| 0| 2| 1| 5| 1| 1| 0| 8| 1| 1| 1| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 55 |
Amyloid Deposition | 3 | 1 3.0|
Glomerulosclerosis | | 1 4.0|
Inflammation, Chronic | 2 1 2 2 2 2 2 2 1 3 2 | 44 1.9|
Nephropathy | | 1 4.0|
Renal Tubule, Mineralization | 3 | 2 2.5|
__________________________________________________________________________|____________|
Urethra | | 2 |
Distal, Concretion | | 1 4.0|
Distal, Inflammation, Suppurative | | 1 2.0|
Proximal, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 55 |
Muscularis, Hemorrhage | 3 | 1 3.0|
Submucosa, Inflammation, Chronic | 1 1 2 1 2 2 | 13 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 730386-730386/730386
--multipart-boundary--