TDMS Study 05040-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: American Biogenics DATE: 09/05/94
EXP: 05040 HYDROQUINONE TIME: 12:08:41
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55834B
CONT: CAS: 000123319
PATHOLOGIST: S. WYAND S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: American Biogenics DATE: 09/05/94
EXP: 05040 HYDROQUINONE TIME: 12:08:41
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55834B
CONT: CAS: 000123319
PATHOLOGIST: S. WYAND S. EUSTIS
HYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 65 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 330 347 408 421 537 555 604 605 630 635 |
| 648 649 662 681 682 683 684 691 694 698 |
| 701 709 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 64 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 218 368 441 465 479 547 596 648 652 654 |
| 654 656 662 684 688 691 701 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100MG/KG |
| --------------------- |
| |
| TOTAL 65 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 330 481 526 563 575 625 634 635 642 649 |
| 655 657 661 663 680 681 682 690 697 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
==================================================================================
HYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 96.9 93.8 93.8 92.0 86.5 77.3 60.7 |
|CONTROL | |
| | |
|50 MG/KG | 100.0 100.0 98.4 98.4 96.9 91.6 91.6 87.8 76.6 69.1 |
| | |
| | |
|100MG/KG | 100.0 100.0 100.0 98.5 98.5 96.6 94.8 91.2 74.8 65.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 50 MG/KG 100MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.7% 69.1% 65.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.649N P=0.494N P=0.719N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 602.5 576.7 617.2 |
|NATURAL DEATHS (C) | (25.4) (33.4) (20.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 644.5 646.2 654.6 |
|(STANDARD ERROR) | (14.9) (15.7) (13.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
HYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 65 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 293 372 406 431 469 495 540 558 583 596 |
| 631 637 652 664 676 691 693 696 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 65 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 409 440 534 561 606 616 630 640 660 668 |
| 668 680 683 717 721 729 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100MG/KG |
| --------------------- |
| |
| TOTAL 65 UNCENSORED DEATHS 15 CENSORED DEATHS 14 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 136 389 548 561 622 641 644 652 656 672 |
| 686 700 702 721 729 |
| CENSORED DEATHS |
| 14 15 15 15 457 457 457 457 457 457 |
| 457 457 457 457 |
| |
==================================================================================
HYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 98.5 95.4 92.0 88.3 82.8 75.4 68.1 |
|CONTROL | |
| | |
|50 MG/KG | 100.0 100.0 100.0 100.0 98.5 96.9 95.1 93.3 84.1 71.3 |
| | |
| | |
|100MG/KG | 100.0 98.4 98.4 98.4 96.7 96.7 96.7 92.8 82.9 71.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 50 MG/KG 100MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.1% 71.3% 71.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.638N P=0.690N P=0.714N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 560.2 622.6 603.9 |
|NATURAL DEATHS (C) | (29.1) (23.6) (40.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 643.8 664.6 617.7 |
|(STANDARD ERROR) | (15.8) (13.7) (24.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
HYDROQUINONE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
50 MG/KG = 2
100MG/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1
| 2 1 1 2 3
| 1 2 1 2
| 3 3
95 + 1 1 2 2 3 3
| 1 2 2 1
| 1 13 3
| 2 2 3 3
P 90 + 21 21
E | 33
R | 2 2
C | 1 13322
E 85 + 11
N | 33
T | 1 13
|
S 80 +
U | 12 1
R | 1 1
V | 2 2
I 75 + 3 22
V |
A |
L | 2 2
70 + 11
| 33 2 2
| 11
| 3 3
65 + 11
|
| 11
| 1 1
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 11 obs hidden.
HYDROQUINONE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
50 MG/KG = 2
100MG/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2
| 3 1 1 3 2 2
| 1 1 2 2
| 3 3
95 + 1 1 2 3 2
| 1 1 2 2
P | 1 1 3 3
E | 223 3
R 90 + 1 1 2 2
C | 1 1
E | 2 2
N | 1 1 2 3 2
T 85 + 1 1
| 22
S | 1 1 3 3
U | 3 3
R 80 + 2 2
V | 1 1 3 3
I | 1 1 33
V | 2 2
A 75 + 1 1 3 3
L | 1 1 2 2
| 3 3
| 2
70 + 11
|
| 1 1
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
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