TDMS Study 05040-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
HYDROQUINONE
NTP Experiment-Test: 05040-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 10:19:30
Facility: American Biogenics Corp.
Chemical CAS #: 000123319
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 65 65 65
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 14 19 14
Dead 1 6 6
Gavage Death 3 3
Survivors
Terminal Sacrifice 39 27 31
Dead 1
Accident 1
Animals Examined Microscopically 55 55 55
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (55) (28) (55)
Erosion 1 (2%)
Inflammation, Suppurative 1 (2%)
Liver (55) (55) (55)
Basophilic Focus 30 (55%) 38 (69%) 30 (55%)
Clear Cell Focus 5 (9%) 6 (11%) 5 (9%)
Congestion 1 (2%) 1 (2%) 1 (2%)
Cytomegaly 1 (2%) 2 (4%) 2 (4%)
Degeneration, Cystic 1 (2%) 1 (2%)
Eosinophilic Focus 1 (2%) 2 (4%)
Fatty Change 9 (16%) 10 (18%) 9 (16%)
Fibrosis, Focal 2 (4%)
Focal Cellular Change 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 9 (16%) 10 (18%) 11 (20%)
Hyperplasia, Focal 1 (2%)
Inflammation, Chronic 39 (71%) 30 (55%) 31 (56%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Mineralization 3 (5%) 1 (2%)
Mixed Cell Focus 4 (7%) 1 (2%) 2 (4%)
Necrosis, Coagulative 4 (7%) 3 (5%) 4 (7%)
Arteriole, Inflammation, Proliferative 1 (2%)
Bile Duct, Hyperplasia 41 (75%) 36 (65%) 41 (75%)
Centrilobular, Atrophy 4 (7%) 3 (5%) 10 (18%)
Sinusoid, Dilatation 3 (5%) 1 (2%) 3 (5%)
Mesentery (7) (13) (16)
Pigmentation, Hemosiderin 1 (6%)
Arteriole, Degeneration, Hyaline 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Arteriole, Inflammation, Chronic 1 (14%) 1 (8%)
Fat, Hemorrhage 2 (13%)
Fat, Inflammation, Acute 1 (6%)
Fat, Inflammation, Chronic 6 (46%) 5 (31%)
Fat, Inflammation, Granulomatous 1 (8%)
Fat, Mineralization 1 (8%)
Fat, Necrosis 3 (43%) 5 (38%) 7 (44%)
Fat, Pigmentation, Hemosiderin 1 (6%)
Pancreas (55) (28) (55)
Atrophy 2 (4%) 1 (4%)
Focal Cellular Change 1 (2%)
Inflammation, Chronic 1 (2%)
Duct, Fibrosis 1 (2%)
Duct, Necrosis, Coagulative 1 (4%)
Pharynx (1)
Hyperkeratosis 1 (100%)
Inflammation, Chronic 1 (100%)
Salivary Glands (55) (26) (55)
Atrophy, Focal 1 (2%) 1 (4%) 3 (5%)
Cytoplasmic Alteration 3 (5%) 2 (4%)
Arteriole, Inflammation, Proliferative 1 (2%)
Duct, Ectasia 1 (4%)
Duct, Inflammation, Chronic 13 (24%) 1 (4%) 6 (11%)
Duct, Metaplasia, Squamous 5 (9%) 3 (12%) 12 (22%)
Stomach, Forestomach (55) (28) (54)
Acanthosis 1 (2%) 2 (7%) 2 (4%)
Hyperkeratosis 1 (2%) 2 (7%) 2 (4%)
Hyperplasia, Papillary 1 (2%)
Inflammation, Acute 1 (4%)
Inflammation, Chronic 1 (2%) 1 (2%)
Ulcer 3 (5%) 2 (7%)
Stomach, Glandular (55) (28) (54)
Inflammation, Acute 1 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (55) (28) (55)
Cardiomyopathy 46 (84%) 20 (71%) 42 (76%)
Atrium, Inflammation, Chronic 1 (2%)
Atrium, Thrombosis 1 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (55) (55) (55)
Accessory Adrenal Cortical Nodule 1 (2%) 2 (4%)
Angiectasis 5 (9%) 6 (11%) 4 (7%)
Atrophy 1 (2%)
Cyst 1 (2%) 3 (5%)
Degeneration, Fatty, Focal 8 (15%) 8 (15%) 8 (15%)
Degeneration, Focal 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 2 (4%)
Hyperplasia 10 (18%) 11 (20%) 12 (22%)
Hypertrophy 1 (2%) 1 (2%)
Hypertrophy, Focal 1 (2%)
Necrosis, Coagulative 3 (5%)
Pigmentation, Hemosiderin 1 (2%)
Vacuolization Cytoplasmic 3 (5%) 1 (2%) 7 (13%)
Capsule, Hyperplasia 3 (5%) 1 (2%)
Adrenal Gland, Medulla (54) (55) (54)
Hyperplasia 13 (24%) 8 (15%) 11 (20%)
Islets, Pancreatic (53) (28) (55)
Hyperplasia 1 (2%)
Parathyroid Gland (54) (22) (54)
Hyperplasia 3 (6%) 2 (9%) 2 (4%)
Pituitary Gland (54) (54) (54)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 2 (4%)
Pars Distalis, Cyst 23 (43%) 18 (33%) 20 (37%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 28 (52%) 22 (41%) 26 (48%)
Pars Intermedia, Cyst 1 (2%)
Rathke's Cleft, Crystals 1 (2%)
Thyroid Gland (55) (54) (55)
Ultimobranchial Cyst 1 (2%) 1 (2%)
C-Cell, Hyperplasia 19 (35%) 15 (28%) 14 (25%)
Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (51) (24) (52)
Abscess 1 (2%)
Cyst 4 (8%) 1 (4%) 9 (17%)
Hyperplasia 2 (4%) 2 (8%)
Inflammation, Chronic 7 (14%) 2 (8%) 5 (10%)
Inflammation, Granulomatous 1 (4%) 1 (2%)
Inflammation, Suppurative 5 (10%) 1 (4%) 2 (4%)
Pigmentation, Hemosiderin 1 (4%)
Ovary (55) (29) (55)
Atrophy 2 (4%) 1 (3%)
Corpus Luteum, Cyst 1 (3%) 1 (2%)
Follicle, Cyst 2 (4%) 1 (3%)
Periovarian Tissue, Cyst 1 (2%) 1 (3%) 2 (4%)
Oviduct (2)
Inflammation, Chronic 1 (50%)
Uterus (55) (55) (55)
Inflammation, Suppurative 1 (2%) 2 (4%)
Cervix, Abscess 2 (4%) 6 (11%) 4 (7%)
Cervix, Inflammation, Proliferative 1 (2%) 1 (2%)
Cervix, Prolapse 2 (4%)
Cervix, Epithelium, Degeneration, Mucoid 1 (2%)
Endometrium, Hyperplasia, Cystic 17 (31%) 16 (29%) 15 (27%)
Vagina (2) (1) (1)
Dilatation 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (8) (10) (18)
Neutrophilia 2 (20%) 2 (11%)
Thrombocytopenia 1 (10%)
Erythrocyte, Poikilocytosis 1 (10%)
Bone Marrow (55) (28) (55)
Myelofibrosis 1 (2%) 1 (4%)
Erythroid Cell, Hyperplasia 1 (2%) 1 (2%)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (55) (28) (55)
Mediastinal, Hyperplasia, Macrophage 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (4%)
Mediastinal, Pigmentation, Hemosiderin 1 (2%)
Mediastinal, Sinus, Ectasia 1 (4%)
Pancreatic, Hematopoietic Cell Proliferation 1 (2%)
Pancreatic, Sinus, Ectasia 1 (4%)
Lymph Node, Mandibular (55) (26) (52)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Macrophage 1 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Plasma Cell 4 (7%) 1 (4%) 2 (4%)
Sinus, Ectasia 3 (5%) 2 (4%)
Lymph Node, Mesenteric (53) (28) (54)
Congestion 1 (2%) 1 (2%)
Hemorrhage 1 (4%)
Hyperplasia, Macrophage 2 (4%)
Hyperplasia, Plasma Cell 1 (2%)
Sinus, Ectasia 6 (11%) 2 (7%) 3 (6%)
Spleen (55) (55) (55)
Fibrosis 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 2 (4%) 5 (9%) 2 (4%)
Infarct 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 2 (4%)
Thymus (52) (27) (51)
Cyst 4 (8%) 1 (4%) 5 (10%)
Arteriole, Mediastinum, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (55) (55) (54)
Abscess 1 (2%)
Cyst 16 (29%) 12 (22%) 14 (26%)
Hyperplasia 36 (65%) 45 (82%) 30 (56%)
Mineralization 1 (2%)
Duct, Fibrosis 1 (2%)
Skin (55) (30) (55)
Abscess 1 (3%)
Cyst Epithelial Inclusion 1 (2%) 1 (3%) 1 (2%)
Inflammation, Chronic 2 (7%)
Ulcer 2 (4%) 2 (7%) 2 (4%)
Subcutaneous Tissue, Cyst 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (55) (28) (55)
Compression 7 (13%) 6 (21%) 2 (4%)
Cerebrum, Mineralization 1 (2%)
Meninges, Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Pons, Hematocyst 1 (2%)
Ventricle, Dilatation 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (55) (29) (55)
Congestion 2 (7%)
Edema 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Macrophage 1 (2%) 1 (3%) 1 (2%)
Hyperplasia, Adenomatous 1 (2%) 1 (3%) 2 (4%)
Pigmentation, Hemosiderin 1 (2%)
Interstitium, Inflammation, Chronic 3 (5%) 2 (7%) 1 (2%)
Interstitium, Inflammation, Granulomatous 1 (2%)
Pleura, Inflammation, Chronic 1 (2%) 3 (5%)
Nose (55) (28) (55)
Exudate 1 (4%)
Hemorrhage 1 (2%)
Inflammation, Chronic 7 (13%) 4 (14%) 4 (7%)
Inflammation, Suppurative 1 (2%)
Lumen, Foreign Body 1 (2%)
Nasolacrimal Duct, Cyst 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 39 (71%) 17 (61%) 28 (51%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Nasolacrimal Duct, Metaplasia, Squamous 52 (95%) 20 (71%) 40 (73%)
Trachea (55) (28) (55)
Inflammation, Chronic 3 (5%) 2 (7%)
Glands, Cyst 1 (2%) 1 (4%) 6 (11%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (6)
Hemorrhage 3 (50%)
Cornea, Proliferation 1 (17%)
Retina, Atrophy 2 (100%) 2 (33%)
Harderian Gland (2) (1) (1)
Inflammation, Chronic 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (55) (55) (55)
Cyst 1 (2%) 1 (2%)
Inflammation, Chronic 17 (31%) 14 (25%) 18 (33%)
Mineralization 3 (5%) 1 (2%) 4 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Necrosis, Coagulative 1 (2%)
Nephropathy 47 (85%) 47 (85%) 46 (84%)
Pelvis, Dilatation 1 (2%) 1 (2%)
Renal Tubule, Inflammation, Suppurative 2 (4%)
Transitional Epithelium, Hyperplasia,
Papillary 1 (2%)
Urinary Bladder (55) (27) (51)
Inflammation, Chronic 5 (9%) 4 (15%) 3 (6%)
Transitional Epithelium, Hyperplasia,
Papillary 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 65 65 65
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 13 25 22
Gavage Death 2 5 7
Dead 13 7 8
Survivors
Terminal Sacrifice 27 18 18
Animals Examined Microscopically 55 55 55
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (34) (50)
Ulcer 1 (3%)
Venule, Thrombosis 1 (3%)
Intestine Large, Colon (51) (35) (53)
Mineralization 1 (2%)
Muscularis, Inflammation, Chronic 1 (2%)
Muscularis, Mineralization 2 (4%)
Serosa, Inflammation, Chronic 1 (3%)
Intestine Large, Rectum (53) (32) (52)
Edema 1 (3%)
Hemorrhage 1 (3%)
Muscularis, Mineralization 1 (2%)
Intestine Small (52) (36) (55)
Capillary, Degeneration, Hyaline 1 (2%)
Intestine Small, Duodenum (52) (35) (55)
Muscularis, Inflammation, Chronic 1 (2%)
Intestine Small, Ileum (48) (33) (49)
Capillary, Degeneration, Hyaline 1 (2%)
Muscularis, Inflammation, Chronic 1 (2%)
Muscularis, Mineralization 1 (2%)
Liver (55) (55) (55)
Basophilic Focus 11 (20%) 11 (20%) 6 (11%)
Clear Cell Focus 1 (2%) 7 (13%) 4 (7%)
Concretion 1 (2%)
Cytomegaly 2 (4%) 1 (2%) 3 (5%)
Degeneration, Cystic 26 (47%) 23 (42%) 18 (33%)
Eosinophilic Focus 4 (7%) 2 (4%) 1 (2%)
Fatty Change 5 (9%) 4 (7%) 4 (7%)
Focal Cellular Change 1 (2%)
Hematocyst 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 3 (5%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatodiaphragmatic Nodule 6 (11%) 10 (18%) 9 (16%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Hyperplasia, Multifocal 1 (2%) 1 (2%)
Inflammation, Chronic 18 (33%) 19 (35%) 19 (35%)
Mixed Cell Focus 6 (11%) 2 (4%)
Necrosis, Coagulative 7 (13%) 4 (7%) 7 (13%)
Necrosis, Coagulative, Multifocal 1 (2%)
Arteriole, Inflammation, Proliferative 3 (5%)
Arteriole, Thrombosis 2 (4%)
Bile Duct, Dilatation 1 (2%)
Bile Duct, Hyperplasia 54 (98%) 52 (95%) 54 (98%)
Centrilobular, Atrophy 5 (9%) 8 (15%) 10 (18%)
Serosa, Fibrosis, Focal 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
Sinusoid, Dilatation 2 (4%) 7 (13%) 4 (7%)
Vein, Dilatation 1 (2%)
Mesentery (12) (16) (9)
Accessory Spleen 3 (19%)
Fat, Inflammation, Chronic 4 (33%) 3 (19%)
Fat, Inflammation, Granulomatous 1 (8%)
Fat, Mineralization 1 (8%)
Fat, Necrosis 3 (25%) 1 (6%) 2 (22%)
Lymphatic, Ectasia 1 (8%)
Pancreas (53) (36) (54)
Atrophy 6 (11%) 6 (17%) 5 (9%)
Hyperplasia, Nodular 1 (2%) 1 (3%)
Inflammation, Chronic 1 (2%)
Acinus, Hyperplasia 1 (2%)
Arteriole, Inflammation, Chronic 1 (2%)
Duct, Inflammation, Chronic 1 (2%) 1 (2%)
Pharynx (1)
Abscess 1 (100%)
Salivary Glands (54) (37) (55)
Atrophy, Focal 1 (2%)
Cytoplasmic Alteration 2 (4%) 1 (3%)
Hyperplasia 1 (3%)
Duct, Hyperplasia 1 (2%)
Duct, Inflammation, Chronic 15 (28%) 3 (8%) 5 (9%)
Duct, Metaplasia, Squamous 12 (22%) 2 (5%) 6 (11%)
Stomach, Forestomach (55) (36) (55)
Abscess 1 (3%)
Acanthosis 3 (5%) 2 (4%)
Edema 1 (2%)
Hemorrhage 1 (3%)
Hyperkeratosis 2 (4%) 2 (4%)
Hyperplasia, Papillary 3 (5%) 2 (6%) 1 (2%)
Inflammation, Chronic 4 (7%) 1 (3%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Ulcer 1 (2%) 3 (8%) 1 (2%)
Ulcer, Chronic 1 (3%)
Epithelium, Degeneration, Ballooning 1 (2%)
Muscularis, Mineralization 4 (7%)
Stomach, Glandular (54) (34) (55)
Erosion 1 (3%)
Inflammation, Acute 1 (3%)
Inflammation, Chronic 1 (3%) 1 (2%)
Mineralization 5 (9%)
Ulcer 1 (3%) 1 (2%)
Tooth (8) (9) (10)
Pulp, Proliferation Connective Tissue, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (55) (38) (55)
Cardiomyopathy 46 (84%) 28 (74%) 47 (85%)
Mineralization 1 (2%) 7 (13%)
Thrombosis 1 (3%)
Atrium, Dilatation 1 (2%)
Atrium, Thrombosis 4 (7%) 5 (13%) 4 (7%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (54) (37) (54)
Accessory Adrenal Cortical Nodule 1 (2%)
Angiectasis 1 (2%) 1 (2%)
Cyst 1 (2%)
Degeneration, Fatty, Focal 6 (11%) 4 (11%) 6 (11%)
Hyperplasia 7 (13%) 4 (11%) 11 (20%)
Necrosis, Coagulative 1 (3%)
Vacuolization Cytoplasmic 5 (9%) 7 (19%) 7 (13%)
Capsule, Hyperplasia 1 (3%) 1 (2%)
Adrenal Gland, Medulla (55) (48) (55)
Atrophy 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 19 (35%) 19 (40%) 22 (40%)
Mineralization 1 (2%)
Islets, Pancreatic (54) (36) (54)
Hyperplasia 3 (6%) 2 (6%)
Parathyroid Gland (54) (36) (54)
Cyst 1 (2%)
Hyperplasia 13 (24%) 6 (17%) 19 (35%)
Pituitary Gland (54) (54) (54)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cyst 7 (13%) 8 (15%) 7 (13%)
Pars Distalis, Fibrosis 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 12 (22%) 14 (26%) 11 (20%)
Pars Distalis, Necrosis 1 (2%) 1 (2%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (55) (38) (55)
Ultimobranchial Cyst 2 (4%) 1 (2%)
C-Cell, Hyperplasia 4 (7%) 5 (13%) 7 (13%)
Follicle, Cyst 1 (3%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (2)
Inflammation, Chronic 1 (50%)
Inflammation, Suppurative 1 (100%)
Epididymis (53) (37) (55)
Degeneration, Mucoid 1 (2%) 4 (7%)
Inflammation, Chronic 1 (2%)
Preputial Gland (53) (34) (54)
Abscess 1 (2%) 1 (3%) 1 (2%)
Cyst 5 (9%) 2 (6%) 7 (13%)
Hyperplasia 2 (4%) 1 (3%) 1 (2%)
Inflammation, Chronic 12 (23%) 13 (38%) 13 (24%)
Inflammation, Suppurative 5 (9%) 2 (6%) 1 (2%)
Necrosis, Coagulative 1 (2%)
Pigmentation, Hemosiderin 2 (4%)
Prostate (53) (41) (55)
Abscess 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 3 (6%) 4 (10%) 4 (7%)
Hyperplasia, Focal 1 (2%)
Inflammation, Chronic 7 (13%) 1 (2%) 5 (9%)
Inflammation, Suppurative 9 (17%) 8 (20%) 13 (24%)
Seminal Vesicle (53) (36) (55)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Testes (54) (54) (55)
Atrophy 39 (72%) 31 (57%) 35 (64%)
Cyst 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Bilateral, Interstitial Cell, Hyperplasia 1 (2%)
Interstitial Cell, Hyperplasia 11 (20%) 7 (13%) 7 (13%)
Seminiferous Tubule, Degeneration, Cystic 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (22) (25) (29)
Anemia 2 (8%)
Hypersegmentation 1 (4%)
Left Shift 1 (5%)
Neutrophilia 2 (9%) 3 (12%) 1 (3%)
Thrombocytopenia 1 (5%) 2 (8%)
Bone Marrow (55) (37) (55)
Depletion Cellular 1 (3%)
Myelofibrosis 2 (5%) 3 (5%)
Erythroid Cell, Hyperplasia 2 (4%)
Myeloid Cell, Hyperplasia 1 (2%) 3 (8%) 3 (5%)
Lymph Node (55) (41) (55)
Bronchial, Pigmentation, Hemosiderin 1 (2%)
Bronchial, Sinus, Ectasia 1 (2%) 1 (2%)
Cortex, Mediastinal, Atrophy 1 (2%)
Iliac, Hyperplasia, Plasma Cell 1 (2%)
Iliac, Sinus, Ectasia 1 (2%) 1 (2%)
Inguinal, Hyperplasia, Lymphoid 1 (2%)
Inguinal, Hyperplasia, Plasma Cell 1 (2%) 1 (2%) 2 (4%)
Inguinal, Sinus, Ectasia 1 (2%) 1 (2%)
Lumbar, Hyperplasia, Macrophage 1 (2%)
Lumbar, Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Lumbar, Pigmentation, Hemosiderin 1 (2%)
Lumbar, Sinus, Ectasia 2 (5%)
Mediastinal, Hyperplasia, Macrophage 2 (4%) 1 (2%) 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Mediastinal, Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Mediastinal, Sinus, Ectasia 1 (2%) 2 (5%) 3 (5%)
Pancreatic, Hyperplasia, Macrophage 1 (2%)
Pancreatic, Sinus, Ectasia 2 (4%) 1 (2%)
Renal, Pigmentation, Hemosiderin 1 (2%)
Renal, Sinus, Ectasia 1 (2%) 1 (2%)
Lymph Node, Mandibular (52) (38) (54)
Congestion 1 (2%)
Hyperplasia, Lymphoid 1 (3%)
Hyperplasia, Plasma Cell 2 (4%) 4 (11%) 3 (6%)
Sinus, Ectasia 7 (13%) 3 (8%) 4 (7%)
Lymph Node, Mesenteric (53) (38) (54)
Congestion 1 (2%)
Depletion Lymphoid 2 (5%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Macrophage 2 (4%) 3 (8%) 1 (2%)
Hyperplasia, Plasma Cell 3 (6%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Sinus, Ectasia 9 (17%) 5 (13%) 3 (6%)
Spleen (55) (52) (55)
Fibrosis 7 (13%) 5 (10%) 8 (15%)
Hematopoietic Cell Proliferation 3 (5%) 5 (10%) 3 (5%)
Hemorrhage 1 (2%)
Hyperplasia, Macrophage 1 (2%) 1 (2%)
Capsule, Infarct 1 (2%)
Capsule, Inflammation, Chronic 1 (2%)
Red Pulp, Depletion Cellular 1 (2%)
Thymus (46) (35) (46)
Congestion 1 (2%)
Cyst 1 (2%) 1 (3%) 2 (4%)
Inflammation 1 (3%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (29) (53)
Cyst 1 (2%)
Hyperplasia 14 (29%) 8 (28%) 10 (19%)
Mineralization 1 (2%)
Skin (55) (37) (54)
Abscess 1 (2%)
Cyst Epithelial Inclusion 1 (3%)
Inflammation, Chronic 4 (7%) 2 (5%) 5 (9%)
Inflammation, Granulomatous 1 (3%)
Inflammation, Suppurative 1 (2%)
Inflammation, Proliferative 1 (2%)
Ulcer 1 (2%) 6 (16%) 4 (7%)
Hindlimb, Subcutaneous Tissue, Right,
Inflammation, Acute 1 (3%)
Hindlimb, Right, Epidermis, Abscess, Multiple 1 (3%)
Hindlimb, Right, Epidermis, Degeneration,
Ballooning 1 (3%)
Scrotal, Inflammation, Suppurative 1 (2%)
Sebaceous Gland, Hyperplasia 1 (3%)
Subcutaneous Tissue, Abscess 2 (4%)
Subcutaneous Tissue, Cyst 1 (3%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 2 (4%) 1 (3%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (55) (37) (55)
Fibrous Osteodystrophy 1 (2%)
Inflammation, Chronic Active 1 (3%)
Skeletal Muscle (4) (3) (6)
Degeneration 1 (17%)
Inflammation, Chronic 1 (25%)
Mineralization 1 (17%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (55) (37) (55)
Compression 4 (7%) 2 (5%) 3 (5%)
Cerebellum, Embolus Tumor 1 (3%)
Cerebellum, Infarct 1 (3%)
Choroid Plexus, Inflammation, Chronic 1 (3%)
Ventricle, Dilatation 1 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (1) (1)
Hemorrhage 1 (100%)
Inflammation, Chronic 1 (100%)
Lung (55) (38) (55)
Atelectasis 1 (2%)
Congestion 2 (4%) 1 (3%)
Crystals 1 (2%)
Hemorrhage 1 (3%) 3 (5%)
Hyperplasia, Macrophage 7 (13%) 2 (5%) 6 (11%)
Hyperplasia, Adenomatous 3 (5%) 2 (5%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 2 (4%)
Necrosis, Coagulative 1 (2%)
Necrosis, Liquifactive 1 (2%)
Proliferation Connective Tissue 1 (2%)
Arteriole, Thrombosis 2 (4%)
Arteriole, Media, Hyperplasia 1 (3%)
Bronchiole, Foreign Body 1 (2%)
Interstitium, Fibrosis 1 (2%)
Interstitium, Inflammation, Chronic 4 (7%) 2 (5%) 1 (2%)
Pleura, Inflammation, Chronic 4 (7%) 2 (4%)
Nose (55) (37) (55)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Chronic 8 (15%) 7 (19%) 6 (11%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Metaplasia, Squamous 1 (3%)
Nasolacrimal Duct, Inflammation, Chronic 27 (49%) 21 (57%) 34 (62%)
Nasolacrimal Duct, Inflammation, Suppurative 3 (5%) 2 (5%) 2 (4%)
Nasolacrimal Duct, Metaplasia, Squamous 45 (82%) 24 (65%) 47 (85%)
Respiratory Epithelium, Cyst 1 (3%)
Trachea (53) (37) (55)
Exudate 1 (2%)
Inflammation, Chronic 3 (6%) 1 (3%) 1 (2%)
Glands, Cyst 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (2)
Exudate 1 (50%)
Middle Ear, Inflammation, Suppurative 1 (50%)
Eye (2) (3) (4)
Hemorrhage 1 (33%)
Synechia 2 (67%)
Cornea, Inflammation, Subacute 1 (25%)
Cornea, Necrosis 1 (25%)
Cornea, Proliferation 1 (33%)
Retina, Atrophy 3 (100%) 2 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (55) (55) (55)
Cyst 2 (4%) 6 (11%)
Hemorrhage 1 (2%)
Infarct 1 (2%) 1 (2%)
Inflammation, Chronic 27 (49%) 30 (55%) 27 (49%)
Mineralization 1 (2%)
Necrosis, Coagulative 1 (2%)
Nephropathy 53 (96%) 52 (95%) 55 (100%)
Pelvis, Hematopoietic Cell Proliferation 1 (2%)
Pelvis, Inflammation, Suppurative 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Hyperplasia, Focal 1 (2%)
Renal Tubule, Inflammation, Suppurative 4 (7%) 7 (13%)
Transitional Epithelium, Hyperplasia,
Papillary 1 (2%) 6 (11%) 5 (9%)
Urinary Bladder (51) (37) (55)
Hyperplasia, Papillary 1 (3%)
Inflammation, Chronic 7 (14%) 1 (3%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%)
Submucosa, Edema 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
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