TDMS Study 05040-01 Pathology Tables
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
Facility: American Biogenics Corp.
Chemical CAS #: 000123319
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 0| 0| 3| 3| 3| 0| 5| 3| 3| 2| 7| 7| 3| 3| 3| 5| 4| 3| 3| 3| 2| 5|
| 1| 9| 2| 1| 0| 1| 0| 0| 2| 8| 1| 1| 9| 5| 2| 0| 0| 0| 8| 6| 1| 0| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | + |
Pulp, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + M + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 0| 0| 3| 3| 3| 0| 5| 3| 3| 2| 7| 7| 3| 3| 3| 5| 4| 3| 3| 3| 2| 5|
| 1| 9| 2| 1| 0| 1| 0| 0| 2| 8| 1| 1| 9| 5| 2| 0| 0| 0| 8| 6| 1| 0| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenocarcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + M M + + + + + + + + + |
Adenoma | X X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + |
Granulosa Cell Tumor Malignant | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Polyp Stromal | X X X |
Endometrium, Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + |
Inguinal, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + M + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 0| 0| 3| 3| 3| 0| 5| 3| 3| 2| 7| 7| 3| 3| 3| 5| 4| 3| 3| 3| 2| 5|
| 1| 9| 2| 1| 0| 1| 0| 0| 2| 8| 1| 1| 9| 5| 2| 0| 0| 0| 8| 6| 1| 0| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Adenocarcinoma | X |
Adenocarcinoma, Multiple | |
Fibroadenoma | X X X X X X X X X X X X |
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Meninges, Leukemia Mononuclear | X |
Pons, Carcinoma, Metastatic | X |
__________________________________________________________________________|
Spinal Cord | + + + + |
Leukemia Mononuclear | |
Meninges, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 2| 2| 5| 5| 3| 3| 2| 5| 5| 3| 3| 3| 5| 5| 3| 2| 2| 4| 5| 3| 3| 2| 7| 5|
| 9| 9| 9| 3| 8| 1| 0| 9| 8| 8| 1| 1| 1| 8| 8| 1| 9| 9| 7| 8| 1| 1| 9| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | + + |
Pulp, Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 2| 2| 5| 5| 3| 3| 2| 5| 5| 3| 3| 3| 5| 5| 3| 2| 2| 4| 5| 3| 3| 2| 7| 5|
| 9| 9| 9| 3| 8| 1| 0| 9| 8| 8| 1| 1| 1| 8| 8| 1| 9| 9| 7| 8| 1| 1| 9| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenocarcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + |
Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + |
Granulosa Cell Tumor Malignant | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Polyp Stromal | X X X X |
Endometrium, Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Inguinal, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 2| 2| 5| 5| 3| 3| 2| 5| 5| 3| 3| 3| 5| 5| 3| 2| 2| 4| 5| 3| 3| 2| 7| 5|
| 9| 9| 9| 3| 8| 1| 0| 9| 8| 8| 1| 1| 1| 8| 8| 1| 9| 9| 7| 8| 1| 1| 9| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + |
Adenocarcinoma | |
Adenocarcinoma, Multiple | X |
Fibroadenoma | X X X X X X X X X |
Fibroadenoma, Multiple | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Meninges, Leukemia Mononuclear | X X |
Pons, Carcinoma, Metastatic | |
__________________________________________________________________________|
Spinal Cord | + + |
Leukemia Mononuclear | X |
Meninges, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 2| 1| 8| 3| 3| 3| 3| 2| 3| 2| 8| 7| 5| | |
| 1| 0| 9| 0| 6| 1| 0| 0| 0| 9| 1| 9| 5| 6| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + A + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + | 54 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + | 54 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Tooth | | 3 |
Pulp, Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 2| 1| 8| 3| 3| 3| 3| 2| 3| 2| 8| 7| 5| | |
| 1| 0| 9| 0| 6| 1| 0| 0| 0| 9| 1| 9| 5| 6| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + | 54 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + A + + + + | 54 |
Leukemia Mononuclear | | 4 |
Pars Distalis, Adenoma | X X X X X X X | 23 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 1 |
Bilateral, C-Cell, Adenoma | X | 1 |
C-Cell, Adenoma | X X X | 8 |
C-Cell, Carcinoma | X | 4 |
Follicular Cell, Adenocarcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + M + + + + | 51 |
Adenoma | X | 4 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + | 55 |
Granulosa Cell Tumor Malignant | | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 3 |
Polyp Stromal | X X X X X | 12 |
Endometrium, Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 8 |
Leukemia Mononuclear | X | 7 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 55 |
Inguinal, Leukemia Mononuclear | X | 2 |
Mediastinal, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 2| 1| 8| 3| 3| 3| 3| 2| 3| 2| 8| 7| 5| | |
| 1| 0| 9| 0| 6| 1| 0| 0| 0| 9| 1| 9| 5| 6| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + | 53 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + | 52 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + | 55 |
Adenocarcinoma | X | 2 |
Adenocarcinoma, Multiple | | 1 |
Fibroadenoma | X X X X X X X | 28 |
Fibroadenoma, Multiple | | 1 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 55 |
Subcutaneous Tissue, Leukemia | | |
Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 2 |
Meninges, Leukemia Mononuclear | | 3 |
Pons, Carcinoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 8 |
Leukemia Mononuclear | | 1 |
Meninges, Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 2| 1| 8| 3| 3| 3| 3| 2| 3| 2| 8| 7| 5| | |
| 1| 0| 9| 0| 6| 1| 0| 0| 0| 9| 1| 9| 5| 6| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 2| 7| 5| 5| 7| 3| 3| 3| 9| 8| 3| 2| 5| 5| 5| 3| 3| 3| 3| 7| 3| 2| 6| 5| 2|
| 1| 2| 8| 8| 3| 1| 0| 0| 5| 7| 1| 4| 8| 8| 8| 1| 1| 1| 0| 6| 0| 9| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + +|
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Tooth | + + |
Pulp, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Complex | |
Bilateral, Pheochromocytoma Benign | X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 2| 7| 5| 5| 7| 3| 3| 3| 9| 8| 3| 2| 5| 5| 5| 3| 3| 3| 3| 7| 3| 2| 6| 5| 2|
| 1| 2| 8| 8| 3| 1| 0| 0| 5| 7| 1| 4| 8| 8| 8| 1| 1| 1| 0| 6| 0| 9| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Adenocarcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + M M + + + + +|
Adenoma | X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
Leukemia Mononuclear | X |
Luteoma | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
Leukemia Mononuclear | X |
Polyp Stromal | X X|
Bilateral, Polyp Stromal | |
Endometrium, Adenocarcinoma | X |
Endometrium, Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 2| 7| 5| 5| 7| 3| 3| 3| 9| 8| 3| 2| 5| 5| 5| 3| 3| 3| 3| 7| 3| 2| 6| 5| 2|
| 1| 2| 8| 8| 3| 1| 0| 0| 5| 7| 1| 4| 8| 8| 8| 1| 1| 1| 0| 6| 0| 9| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + M + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Fibroadenoma | X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + +|
Basal Cell Adenoma | X |
Keratoacanthoma | |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + +|
Cartilage, Adenocarcinoma, Extension,| |
Metastatic, Thyroid Gland | |
__________________________________________________________________________|
Skeletal Muscle | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + +|
Astrocytoma Malignant | |
Leukemia Mononuclear | X X |
Meninges, Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | + + + |
Leukemia Mononuclear | |
Meninges, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | M |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 2| 7| 5| 5| 7| 3| 3| 3| 9| 8| 3| 2| 5| 5| 5| 3| 3| 3| 3| 7| 3| 2| 6| 5| 2|
| 1| 2| 8| 8| 3| 1| 0| 0| 5| 7| 1| 4| 8| 8| 8| 1| 1| 1| 0| 6| 0| 9| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 1| 0| 5| 3| 3| 2| 1| 4| 2| 2| 0| 5| 3| 2| 0| 0| 5| 5|
| 1| 1| 5| 4| 0| 1| 1| 9| 0| 8| 1| 0| 9| 0| 4| 9| 9| 8| 5| 3| 9| 0| 0| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + A + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + +|
__________________________________________________________________________|
Pharynx | M + |
__________________________________________________________________________|
Salivary Glands | + + + M + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Tooth | + |
Pulp, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Complex | |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 1| 0| 5| 3| 3| 2| 1| 4| 2| 2| 0| 5| 3| 2| 0| 0| 5| 5|
| 1| 1| 5| 4| 0| 1| 1| 9| 0| 8| 1| 0| 9| 0| 4| 9| 9| 8| 5| 3| 9| 0| 0| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X|
Pars Distalis, Carcinoma | X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
Follicular Cell, Adenocarcinoma | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M M + M + M M + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
Leukemia Mononuclear | X X |
Luteoma | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
Leukemia Mononuclear | X |
Polyp Stromal | X X X |
Bilateral, Polyp Stromal | X |
Endometrium, Adenocarcinoma | |
Endometrium, Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 1| 0| 5| 3| 3| 2| 1| 4| 2| 2| 0| 5| 3| 2| 0| 0| 5| 5|
| 1| 1| 5| 4| 0| 1| 1| 9| 0| 8| 1| 0| 9| 0| 4| 9| 9| 8| 5| 3| 9| 0| 0| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + M M + M + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Fibroadenoma | X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Keratoacanthoma | |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + +|
Cartilage, Adenocarcinoma, Extension,| |
Metastatic, Thyroid Gland | |
__________________________________________________________________________|
Skeletal Muscle | + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Leukemia Mononuclear | X |
Meninges, Leukemia Mononuclear | X |
__________________________________________________________________________|
Spinal Cord | + + + |
Leukemia Mononuclear | X |
Meninges, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 1| 0| 5| 3| 3| 2| 1| 4| 2| 2| 0| 5| 3| 2| 0| 0| 5| 5|
| 1| 1| 5| 4| 0| 1| 1| 9| 0| 8| 1| 0| 9| 0| 4| 9| 9| 8| 5| 3| 9| 0| 0| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 2| 6| 5| 5| 3| 3| 0| 9| 5| 2| 2| 2| 7| 6| | |
| 0| 9| 8| 8| 8| 0| 0| 9| 2| 8| 9| 9| 9| 2| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + | 28 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 28 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 23 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X | 15 |
__________________________________________________________________________|____________|
Mesentery | + + + | 13 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 28 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 26 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 28 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 28 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 28 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Tooth | | 3 |
Pulp, Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 28 |
Leukemia Mononuclear | X | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X | 8 |
Pheochromocytoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 2| 6| 5| 5| 3| 3| 0| 9| 5| 2| 2| 2| 7| 6| | |
| 0| 9| 8| 8| 8| 0| 0| 9| 2| 8| 9| 9| 9| 2| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Complex | X | 1 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 28 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M M + | 22 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X X X X X X | 21 |
Pars Distalis, Carcinoma | | 1 |
Pars Distalis, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 54 |
C-Cell, Adenoma | | 3 |
C-Cell, Carcinoma | X | 1 |
Follicular Cell, Adenocarcinoma | X | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 24 |
Adenoma | X | 3 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + | 29 |
Granulosa Cell Tumor Malignant | X | 1 |
Leukemia Mononuclear | | 3 |
Luteoma | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + | 55 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear | | 2 |
Polyp Stromal | | 5 |
Bilateral, Polyp Stromal | | 1 |
Endometrium, Adenocarcinoma | | 1 |
Endometrium, Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 10 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 28 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 2| 6| 5| 5| 3| 3| 0| 9| 5| 2| 2| 2| 7| 6| | |
| 0| 9| 8| 8| 8| 0| 0| 9| 2| 8| 9| 9| 9| 2| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 28 |
Mediastinal, Leukemia Mononuclear | X | 3 |
Pancreatic, Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + | 26 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 28 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X | 15 |
__________________________________________________________________________|____________|
Thymus | + + + M M M + + | 27 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 55 |
Adenoma | | 2 |
Fibroadenoma | X X X X | 22 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 30 |
Basal Cell Adenoma | | 1 |
Keratoacanthoma | X | 1 |
Subcutaneous Tissue, Leukemia | | |
Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 28 |
Cartilage, Adenocarcinoma, Extension,| | |
Metastatic, Thyroid Gland | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 28 |
Astrocytoma Malignant | | 1 |
Leukemia Mononuclear | | 3 |
Meninges, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 7 |
Leukemia Mononuclear | | 1 |
Meninges, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 2| 6| 5| 5| 3| 3| 0| 9| 5| 2| 2| 2| 7| 6| | |
| 0| 9| 8| 8| 8| 0| 0| 9| 2| 8| 9| 9| 9| 2| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 29 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Nose | + + + + + | 28 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 28 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 27 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 3| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 9| 8| 5| 3| 3| 3| 5| 5| 1| 5| 3| 5| 4| 3| 3| 2| 5| 9| 3| 3| 2| 5| 5|
| 9| 9| 5| 7| 8| 1| 1| 0| 8| 8| 6| 8| 8| 8| 3| 0| 0| 9| 2| 8| 1| 0| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + M A M + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Sarcoma | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + A + + + + + + + + + + + + |
Cystadenocarcinoma | |
Leukemia Mononuclear | X |
Sarcoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + + |
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant, | |
Extension, Metastatic, Adrenal | |
Gland | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Tooth | |
Pulp, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 3| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 9| 8| 5| 3| 3| 3| 5| 5| 1| 5| 3| 5| 4| 3| 3| 2| 5| 9| 3| 3| 2| 5| 5|
| 9| 9| 5| 7| 8| 1| 1| 0| 8| 8| 6| 8| 8| 8| 3| 0| 0| 9| 2| 8| 1| 0| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Meningioma Malignant, Metastatic | X |
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + M + + + M + + + + + |
Adenoma | X X X X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Oviduct | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Polyp Stromal | X X X |
__________________________________________________________________________|
Vagina | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Axillary, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 3| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 9| 8| 5| 3| 3| 3| 5| 5| 1| 5| 3| 5| 4| 3| 3| 2| 5| 9| 3| 3| 2| 5| 5|
| 9| 9| 5| 7| 8| 1| 1| 0| 8| 8| 6| 8| 8| 8| 3| 0| 0| 9| 2| 8| 1| 0| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Deep Cervical, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + M + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + |
Adenocarcinoma | X |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Keratoacanthoma | X X |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Leukemia Mononuclear | |
Pheochromocytoma Malignant, | |
Extension, Metastatic, Adrenal | |
Gland | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Meninges, Leukemia Mononuclear | X |
Meninges, Meningioma Malignant | X |
__________________________________________________________________________|
Spinal Cord | + + + |
Meninges, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 3| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 9| 8| 5| 3| 3| 3| 5| 5| 1| 5| 3| 5| 4| 3| 3| 2| 5| 9| 3| 3| 2| 5| 5|
| 9| 9| 5| 7| 8| 1| 1| 0| 8| 8| 6| 8| 8| 8| 3| 0| 0| 9| 2| 8| 1| 0| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + + + + + + + M + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 5| 4| 4|
DAY ON TEST | 2| 1| 1| 9| 3| 2| 0| 5| 5| 5| 3| 3| 3| 3| 9| 3| 3| 2| 2| 5| 0| 6| 8| 5| 5|
| 9| 4| 1| 4| 4| 9| 7| 8| 8| 8| 1| 0| 0| 0| 7| 0| 0| 9| 9| 8| 3| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Sarcoma | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + |
Cystadenocarcinoma | X |
Leukemia Mononuclear | |
Sarcoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Mesentery | M + + + + + + + |
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant, | |
Extension, Metastatic, Adrenal | |
Gland | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Stomach | + + A + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Tooth | + + + + |
Pulp, Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 5| 4| 4|
DAY ON TEST | 2| 1| 1| 9| 3| 2| 0| 5| 5| 5| 3| 3| 3| 3| 9| 3| 3| 2| 2| 5| 0| 6| 8| 5| 5|
| 9| 4| 1| 4| 4| 9| 7| 8| 8| 8| 1| 0| 0| 0| 7| 0| 0| 9| 9| 8| 3| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Meningioma Malignant, Metastatic | |
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X X X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Oviduct | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Polyp Stromal | X X X X |
__________________________________________________________________________|
Vagina | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Axillary, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 5| 4| 4|
DAY ON TEST | 2| 1| 1| 9| 3| 2| 0| 5| 5| 5| 3| 3| 3| 3| 9| 3| 3| 2| 2| 5| 0| 6| 8| 5| 5|
| 9| 4| 1| 4| 4| 9| 7| 8| 8| 8| 1| 0| 0| 0| 7| 0| 0| 9| 9| 8| 3| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Deep Cervical, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X X |
Pancreatic, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + M M + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + |
Adenocarcinoma | |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Keratoacanthoma | |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant, | |
Extension, Metastatic, Adrenal | |
Gland | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Meninges, Leukemia Mononuclear | X X |
Meninges, Meningioma Malignant | |
__________________________________________________________________________|
Spinal Cord | + + + + + |
Meninges, Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 5| 4| 4|
DAY ON TEST | 2| 1| 1| 9| 3| 2| 0| 5| 5| 5| 3| 3| 3| 3| 9| 3| 3| 2| 2| 5| 0| 6| 8| 5| 5|
| 9| 4| 1| 4| 4| 9| 7| 8| 8| 8| 1| 0| 0| 0| 7| 0| 0| 9| 9| 8| 3| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 3| 2| 2| 2| 9| 3| 3| 3| 3| 9| | |
| 1| 0| 9| 6| 8| 0| 9| 9| 9| 0| 1| 1| 0| 0| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + | 51 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + | 53 |
Leukemia Mononuclear | X | 3 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + | 51 |
Cystadenocarcinoma | | 1 |
Leukemia Mononuclear | | 1 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X X X | 22 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 16 |
Leukemia Mononuclear | | 8 |
Pheochromocytoma Malignant, | | |
Extension, Metastatic, Adrenal | | |
Gland | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Tooth | + | 5 |
Pulp, Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 3| 2| 2| 2| 9| 3| 3| 3| 3| 9| | |
| 1| 0| 9| 6| 8| 0| 9| 9| 9| 0| 1| 1| 0| 0| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X X | 13 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 55 |
Adenoma | | 1 |
Leukemia Mononuclear | X X X X | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X X X X | 12 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X X X | 8 |
Meningioma Malignant, Metastatic | | 1 |
Pars Distalis, Adenoma | X X X X X X | 16 |
Pars Distalis, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | X X X | 5 |
C-Cell, Carcinoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + | 52 |
Adenoma | X | 9 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Oviduct | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 4 |
Polyp Stromal | X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 3| 2| 2| 2| 9| 3| 3| 3| 3| 9| | |
| 1| 0| 9| 6| 8| 0| 9| 9| 9| 0| 1| 1| 0| 0| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Vagina | + | 1 |
Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + | 18 |
Leukemia Mononuclear | X X X X | 15 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 55 |
Axillary, Leukemia Mononuclear | | 1 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Inguinal, Leukemia Mononuclear | | 3 |
Lumbar, Leukemia Mononuclear | | 2 |
Mediastinal, Leukemia Mononuclear | X | 6 |
Pancreatic, Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 52 |
Leukemia Mononuclear | X X X X | 13 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X X X X | 16 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X X X | 22 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + | 51 |
Leukemia Mononuclear | X X X X | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + | 54 |
Adenocarcinoma | | 1 |
Fibroadenoma | X X X X X X X | 21 |
Fibroadenoma, Multiple | | 1 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 55 |
Keratoacanthoma | | 2 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Leukemia | | |
Mononuclear | X | 4 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 3| 2| 2| 2| 9| 3| 3| 3| 3| 9| | |
| 1| 0| 9| 6| 8| 0| 9| 9| 9| 0| 1| 1| 0| 0| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Leukemia Mononuclear | | 1 |
Pheochromocytoma Malignant, | | |
Extension, Metastatic, Adrenal | | |
Gland | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 3 |
Meninges, Leukemia Mononuclear | X | 4 |
Meninges, Meningioma Malignant | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + | 12 |
Meninges, Leukemia Mononuclear | X X X | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 55 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X X X | 15 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 6 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X X | 16 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + M | 51 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 3| 2| 2| 2| 9| 3| 3| 3| 3| 9| | |
| 1| 0| 9| 6| 8| 0| 9| 9| 9| 0| 1| 1| 0| 0| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X X X X | 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 2| 7| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 7| 3| 3| 3| 4| 3| 3| 7| 3| 8| 3| 3| 6| 6| 5|
| 1| 1| 1| 7| 9| 2| 2| 2| 1| 9| 3| 2| 1| 1| 6| 2| 0| 6| 7| 3| 2| 1| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + A + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + |
Leukemia Mononuclear | X X |
Serosa, Histiocytic Sarcoma, | |
Metastatic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + |
Leukemia Mononuclear | X X |
Serosa, Ileum, Jejunum, Histiocytic | |
Sarcoma, Metastatic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + A + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + M + + A + + + + + + A + + + + A + |
Leiomyosarcoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | X |
Histiocytic Sarcoma, Metastatic | |
Leiomyosarcoma, Metastatic, | |
Intestine Small | X |
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Histiocytic Sarcoma, Metastatic | |
Leiomyosarcoma, Extension, | |
Metastatic, Intestine Small | X |
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Pharynx | |
Palate, Carcinoma, Extension, | |
Metastatic, Zymbal's Gland | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Serosa, Glandular, Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 2| 7| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 7| 3| 3| 3| 4| 3| 3| 7| 3| 8| 3| 3| 6| 6| 5|
| 1| 1| 1| 7| 9| 2| 2| 2| 1| 9| 3| 2| 1| 1| 6| 2| 0| 6| 7| 3| 2| 1| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Sarcoma, Metastatic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Tooth | + + + |
Pulp, Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Endocardium, Schwannoma NOS | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenocarcinoma | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + M + |
Histiocytic Sarcoma, Metastatic | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 2| 7| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 7| 3| 3| 3| 4| 3| 3| 7| 3| 8| 3| 3| 6| 6| 5|
| 1| 1| 1| 7| 9| 2| 2| 2| 1| 9| 3| 2| 1| 1| 6| 2| 0| 6| 7| 3| 2| 1| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Leukemia Mononuclear | X X |
Mesothelioma Malignant, Metastatic | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + M + + + + + + + + + + + + + |
Adenoma | X X X X X |
Carcinoma | X |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X |
Mesothelioma Malignant, Metastatic | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Serosa, Histiocytic Sarcoma, | |
Metastatic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Serosa, Histiocytic Sarcoma, | |
Metastatic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + M + |
Leukemia Mononuclear | X X X X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X |
Tunic, Histiocytic Sarcoma, | |
Metastatic | |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Axillary, Leukemia Mononuclear | X |
Bronchial, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | X X |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X X |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 2| 7| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 7| 3| 3| 3| 4| 3| 3| 7| 3| 8| 3| 3| 6| 6| 5|
| 1| 1| 1| 7| 9| 2| 2| 2| 1| 9| 3| 2| 1| 1| 6| 2| 0| 6| 7| 3| 2| 1| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X |
Inguinal, Lumbar, Mediastinal, | |
Histiocytic Sarcoma, Metastatic | |
Mediastinal, Mandibular, Histiocytic | |
Sarcoma, Metastatic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X X X X X X X X X |
Capsule, Histiocytic Sarcoma, | |
Metastatic | |
__________________________________________________________________________|
Thymus | M + + + + + M + + + + + + + M + + + + M + + |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + M + + + + + + + + + + + + + |
Adenocarcinoma | X |
Adenoma | X |
Fibroadenoma | X |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
Keratoacanthoma | X |
Hair Follicle, Leukemia Mononuclear | |
Posterior, Leukemia Mononuclear | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
Vertebra, Leukemia Mononuclear | |
__________________________________________________________________________|
Skeletal Muscle | + |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Meninges, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 2| 7| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 7| 3| 3| 3| 4| 3| 3| 7| 3| 8| 3| 3| 6| 6| 5|
| 1| 1| 1| 7| 9| 2| 2| 2| 1| 9| 3| 2| 1| 1| 6| 2| 0| 6| 7| 3| 2| 1| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Meninges, Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Canal, Carcinoma, Extension, | |
Metastatic, Zymbal's Gland | |
__________________________________________________________________________|
Eye | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Harderian Gland | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
Capsule, Histiocytic Sarcoma, | |
Metastatic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + |
Leukemia Mononuclear | X |
Serosa, Histiocytic Sarcoma, | |
Metastatic | |
Serosa, Mesothelioma Malignant, | |
Metastatic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 3| 7| 6| 6| 4| 4|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 9| 5| 5| 3| 3| 2| 1| 0| 3| 3| 1| 9| 8| 3| 8| 1| 5| 5|
| 7| 2| 1| 1| 2| 1| 1| 6| 9| 9| 1| 1| 9| 5| 2| 2| 2| 3| 3| 1| 1| 3| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + A + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + A + + + + + + + + + |
Leukemia Mononuclear | X |
Serosa, Histiocytic Sarcoma, | |
Metastatic | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Serosa, Ileum, Jejunum, Histiocytic | |
Sarcoma, Metastatic | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + A + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + M + + + A + + + + A + + + |
Leiomyosarcoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | X |
Histiocytic Sarcoma, Metastatic | X |
Leiomyosarcoma, Metastatic, | |
Intestine Small | |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Histiocytic Sarcoma, Metastatic | X |
Leiomyosarcoma, Extension, | |
Metastatic, Intestine Small | |
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pharynx | |
Palate, Carcinoma, Extension, | |
Metastatic, Zymbal's Gland | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Serosa, Glandular, Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 3| 7| 6| 6| 4| 4|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 9| 5| 5| 3| 3| 2| 1| 0| 3| 3| 1| 9| 8| 3| 8| 1| 5| 5|
| 7| 2| 1| 1| 2| 1| 1| 6| 9| 9| 1| 1| 9| 5| 2| 2| 2| 3| 3| 1| 1| 3| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Sarcoma, Metastatic | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Tooth | + + + |
Pulp, Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Endocardium, Schwannoma NOS | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Adenocarcinoma | X X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | X |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 3| 7| 6| 6| 4| 4|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 9| 5| 5| 3| 3| 2| 1| 0| 3| 3| 1| 9| 8| 3| 8| 1| 5| 5|
| 7| 2| 1| 1| 2| 1| 1| 6| 9| 9| 1| 1| 9| 5| 2| 2| 2| 3| 3| 1| 1| 3| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Preputial Gland | M + + + + + + + + + + + + + + + + + + + + |
Adenoma | X X X X X |
Carcinoma | |
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Prostate | + M + + + + + + M + + + + + + + + + + + + |
Leukemia Mononuclear | |
Serosa, Histiocytic Sarcoma, | |
Metastatic | X |
__________________________________________________________________________|
Seminal Vesicle | + M + + + + + + M + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Serosa, Histiocytic Sarcoma, | |
Metastatic | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X |
Tunic, Histiocytic Sarcoma, | |
Metastatic | X |
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Axillary, Leukemia Mononuclear | |
Bronchial, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 3| 7| 6| 6| 4| 4|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 9| 5| 5| 3| 3| 2| 1| 0| 3| 3| 1| 9| 8| 3| 8| 1| 5| 5|
| 7| 2| 1| 1| 2| 1| 1| 6| 9| 9| 1| 1| 9| 5| 2| 2| 2| 3| 3| 1| 1| 3| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X |
Inguinal, Lumbar, Mediastinal, | |
Histiocytic Sarcoma, Metastatic | X |
Mediastinal, Mandibular, Histiocytic | |
Sarcoma, Metastatic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X X X X X X |
Capsule, Histiocytic Sarcoma, | |
Metastatic | X |
__________________________________________________________________________|
Thymus | M + M M + + M + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M + + + M + + + + + + + + + + + M + |
Adenocarcinoma | |
Adenoma | |
Fibroadenoma | X X |
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Keratoacanthoma | X |
Hair Follicle, Leukemia Mononuclear | X |
Posterior, Leukemia Mononuclear | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
Vertebra, Leukemia Mononuclear | |
__________________________________________________________________________|
Skeletal Muscle | + + |
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Meninges, Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 3| 7| 6| 6| 4| 4|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 9| 5| 5| 3| 3| 2| 1| 0| 3| 3| 1| 9| 8| 3| 8| 1| 5| 5|
| 7| 2| 1| 1| 2| 1| 1| 6| 9| 9| 1| 1| 9| 5| 2| 2| 2| 3| 3| 1| 1| 3| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Leukemia Mononuclear | X X |
Meninges, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Canal, Carcinoma, Extension, | |
Metastatic, Zymbal's Gland | |
__________________________________________________________________________|
Eye | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Harderian Gland | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Zymbal's Gland | + + |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Capsule, Histiocytic Sarcoma, | |
Metastatic | X |
__________________________________________________________________________|
Urinary Bladder | + M + + A + + + M + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Serosa, Histiocytic Sarcoma, | |
Metastatic | X |
Serosa, Mesothelioma Malignant, | |
Metastatic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4| | |
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 1| 0| 5| 3| 4| 1| 5| 5| | |
| 2| 2| 1| 4| 9| 1| 0| 0| 2| 9| 2| 6| 5| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + | 50 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + | 51 |
Leukemia Mononuclear | X X | 5 |
Serosa, Histiocytic Sarcoma, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + | 53 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + | 52 |
Leukemia Mononuclear | X X | 5 |
Serosa, Ileum, Jejunum, Histiocytic | | |
Sarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A A + + + + + | 48 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + M A + + + + + | 44 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 55 |
Hepatocellular Adenoma | X | 3 |
Histiocytic Sarcoma, Metastatic | X | 2 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small | | 1 |
Leukemia Mononuclear | X X X X X X | 27 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 12 |
Histiocytic Sarcoma, Metastatic | X | 2 |
Leiomyosarcoma, Extension, | | |
Metastatic, Intestine Small | | 1 |
Leukemia Mononuclear | X X X | 3 |
Mesothelioma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 53 |
Histiocytic Sarcoma, Metastatic | X | 2 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Palate, Carcinoma, Extension, | | |
Metastatic, Zymbal's Gland | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4| | |
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 1| 0| 5| 3| 4| 1| 5| 5| | |
| 2| 2| 1| 4| 9| 1| 0| 0| 2| 9| 2| 6| 5| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X | 4 |
Serosa, Glandular, Histiocytic | | |
Sarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Tongue | | 2 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 8 |
Pulp, Leukemia Mononuclear | X X | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X | 13 |
Endocardium, Schwannoma NOS | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 54 |
Histiocytic Sarcoma, Metastatic | | 1 |
Leukemia Mononuclear | X X X X | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X X | 14 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X X | 9 |
Bilateral, Pheochromocytoma Benign | X X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + | 54 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + | 54 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X X X | 6 |
Pars Distalis, Adenoma | X X X X | 13 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 55 |
Histiocytic Sarcoma, Metastatic | X | 1 |
Leukemia Mononuclear | X X | 4 |
C-Cell, Adenoma | X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4| | |
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 1| 0| 5| 3| 4| 1| 5| 5| | |
| 2| 2| 1| 4| 9| 1| 0| 0| 2| 9| 2| 6| 5| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Carcinoma | | 2 |
Follicular Cell, Adenocarcinoma | | 2 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + M + + + + + + + + + | 53 |
Histiocytic Sarcoma, Metastatic | | 1 |
Leukemia Mononuclear | | 2 |
Mesothelioma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + | 53 |
Adenoma | X | 11 |
Carcinoma | | 1 |
Histiocytic Sarcoma, Metastatic | | 1 |
Leukemia Mononuclear | X X | 5 |
Mesothelioma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + | 53 |
Leukemia Mononuclear | X X | 4 |
Serosa, Histiocytic Sarcoma, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + | 53 |
Leukemia Mononuclear | X | 5 |
Serosa, Histiocytic Sarcoma, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X X | 8 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X | 37 |
Interstitial Cell, Adenoma | X X | 9 |
Tunic, Histiocytic Sarcoma, | | |
Metastatic | | 1 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + | 22 |
Histiocytic Sarcoma, Metastatic | | 1 |
Leukemia Mononuclear | X X X X X | 17 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4| | |
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 1| 0| 5| 3| 4| 1| 5| 5| | |
| 2| 2| 1| 4| 9| 1| 0| 0| 2| 9| 2| 6| 5| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocytic Sarcoma, Metastatic | X | 1 |
Leukemia Mononuclear | X X X X | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 55 |
Axillary, Leukemia Mononuclear | | 1 |
Bronchial, Leukemia Mononuclear | | 1 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | X | 1 |
Inguinal, Leukemia Mononuclear | X | 3 |
Lumbar, Leukemia Mononuclear | X X | 4 |
Mediastinal, Leukemia Mononuclear | X X | 6 |
Pancreatic, Leukemia Mononuclear | X X X | 9 |
Renal, Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + | 52 |
Leukemia Mononuclear | X X X X | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + | 53 |
Leukemia Mononuclear | X X X X X | 18 |
Inguinal, Lumbar, Mediastinal, | | |
Histiocytic Sarcoma, Metastatic | | 1 |
Mediastinal, Mandibular, Histiocytic | | |
Sarcoma, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 55 |
Histiocytic Sarcoma, Metastatic | X | 1 |
Leukemia Mononuclear | X X X X X X X | 28 |
Capsule, Histiocytic Sarcoma, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + | 46 |
Histiocytic Sarcoma, Metastatic | X | 1 |
Leukemia Mononuclear | X X X | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 49 |
Adenocarcinoma | | 1 |
Adenoma | | 1 |
Fibroadenoma | | 3 |
Histiocytic Sarcoma, Metastatic | | 1 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 55 |
Keratoacanthoma | | 2 |
Hair Follicle, Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4| | |
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 1| 0| 5| 3| 4| 1| 5| 5| | |
| 2| 2| 1| 4| 9| 1| 0| 0| 2| 9| 2| 6| 5| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Posterior, Leukemia Mononuclear | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | X | 2 |
Subcutaneous Tissue, Leukemia | | |
Mononuclear | X X | 6 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 55 |
Vertebra, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 4 |
Histiocytic Sarcoma, Metastatic | | 1 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X | 5 |
Meninges, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + M | 13 |
Leukemia Mononuclear | | 2 |
Meninges, Leukemia Mononuclear | X X X | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 55 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Histiocytic Sarcoma, Metastatic | X | 2 |
Leukemia Mononuclear | X X X X | 21 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 53 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
Canal, Carcinoma, Extension, | | |
Metastatic, Zymbal's Gland | X | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4| | |
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 1| 0| 5| 3| 4| 1| 5| 5| | |
| 2| 2| 1| 4| 9| 1| 0| 0| 2| 9| 2| 6| 5| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X X X | 16 |
Capsule, Histiocytic Sarcoma, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + | 51 |
Leukemia Mononuclear | X X X | 5 |
Serosa, Histiocytic Sarcoma, | | |
Metastatic | | 1 |
Serosa, Mesothelioma Malignant, | | |
Metastatic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + | 55 |
Histiocytic Sarcoma | X | 2 |
Leukemia Mononuclear | X X X X X X X | 28 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 6| 4| 2| 7| 6| 5| 5| 4| 0| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 1| 5| 8| 4| 5| 2| 1| 1| 5| 6| 3| 3| 9| 3| 5| 8| 3| 3| 8| 3| 3| 3| 3| 5| 5|
| 8| 1| 3| 0| 9| 5| 7| 0| 9| 3| 2| 2| 9| 6| 9| 6| 2| 1| 9| 1| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Colon, Serosa, Rectum, Mesothelioma | |
Malignant, Metastatic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + M + + + M + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Ileum, Mesothelioma Malignant, | |
Metastatic | |
Serosa, Mesothelioma Malignant, | |
Metastatic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + |
Leiomyosarcoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | X X X X X X X X X X |
Mesothelioma Malignant | |
Mesothelioma Malignant, Metastatic | |
Neoplastic Nodule | X X |
Bile Duct, Leiomyosarcoma, Extension,| |
Metastatic, Intestine Small | |
__________________________________________________________________________|
Mesentery | + + + + |
Leiomyosarcoma, Extension, | |
Metastatic, Intestine Small | |
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 6| 4| 2| 7| 6| 5| 5| 4| 0| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 1| 5| 8| 4| 5| 2| 1| 1| 5| 6| 3| 3| 9| 3| 5| 8| 3| 3| 8| 3| 3| 3| 3| 5| 5|
| 8| 1| 3| 0| 9| 5| 7| 0| 9| 3| 2| 2| 9| 6| 9| 6| 2| 1| 9| 1| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Serosa, Glandular, Mesothelioma | |
Malignant, Metastatic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Tooth | + + + |
Pulp, Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
Atrium, Histiocytic Sarcoma, | |
Metastatic | X |
Atrium Right, Liposarcoma, | |
Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
Capsule, Mesothelioma Malignant, | |
Metastatic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
Pars Distalis, Adenoma | X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 6| 4| 2| 7| 6| 5| 5| 4| 0| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 1| 5| 8| 4| 5| 2| 1| 1| 5| 6| 3| 3| 9| 3| 5| 8| 3| 3| 8| 3| 3| 3| 3| 5| 5|
| 8| 1| 3| 0| 9| 5| 7| 0| 9| 3| 2| 2| 9| 6| 9| 6| 2| 1| 9| 1| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Penis | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + M + + + + M + + |
Adenoma | X X |
Carcinoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + |
Adenoma | |
Leukemia Mononuclear | X X |
Serosa, Mesothelioma Malignant, | |
Metastatic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Serosa, Mesothelioma Malignant, | |
Metastatic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X |
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Bronchial, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | |
Lumbar, Leukemia Mononuclear | X X X |
Mediastinal, Histiocytic Sarcoma, | |
Metastatic | X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
Mesothelioma Malignant, Metastatic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 6| 4| 2| 7| 6| 5| 5| 4| 0| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 1| 5| 8| 4| 5| 2| 1| 1| 5| 6| 3| 3| 9| 3| 5| 8| 3| 3| 8| 3| 3| 3| 3| 5| 5|
| 8| 1| 3| 0| 9| 5| 7| 0| 9| 3| 2| 2| 9| 6| 9| 6| 2| 1| 9| 1| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leiomyosarcoma, Metastatic, | |
Intestine Small | |
Leukemia Mononuclear | X X X X X X X X X X |
Capsule, Mesothelioma Malignant | |
Capsule, Mesothelioma Malignant, | |
Metastatic | |
__________________________________________________________________________|
Thymus | M + + + + + + + M + + + + + M |
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + M + M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
Basosquamous Tumor Malignant | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X X |
Subcutaneous Tissue, Lipoma | X |
Subcutaneous Tissue, Liposarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + |
Leiomyosarcoma, Metastatic, | |
Intestine Small | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Meninges, Leukemia Mononuclear | |
Meninges, Cerebrum, Histiocytic | |
Sarcoma, Metastatic | X |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + + + + + + |
Leukemia Mononuclear | X |
Meninges, Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + |
Carcinoma, Metastatic, Zymbal's Gland| X |
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 6| 4| 2| 7| 6| 5| 5| 4| 0| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 1| 5| 8| 4| 5| 2| 1| 1| 5| 6| 3| 3| 9| 3| 5| 8| 3| 3| 8| 3| 3| 3| 3| 5| 5|
| 8| 1| 3| 0| 9| 5| 7| 0| 9| 3| 2| 2| 9| 6| 9| 6| 2| 1| 9| 1| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Liposarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Adenoma | |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X |
Capsule, Mesothelioma Malignant, | |
Metastatic | |
Renal Tubule, Adenoma | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Serosa, Mesothelioma Malignant, | |
Metastatic | |
Transitional Epithelium, Carcinoma, | |
Papillary | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 6| 6| 4| 7| 7| 6| 4| 4| 7| 6| 6| 6| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 2| 0| 7| 9| 6| 3| 3| 6| 5| 5| 3| 3| 3| 5| 5| 2| 6| 5| 5| 5| 9| 3| 1| 0| 5|
| 3| 9| 6| 0| 6| 1| 1| 2| 5| 9| 2| 1| 8| 9| 9| 8| 8| 6| 3| 9| 2| 1| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + + + + + + + + + A +|
Leukemia Mononuclear | |
Colon, Serosa, Rectum, Mesothelioma | |
Malignant, Metastatic | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Ileum, Mesothelioma Malignant, | |
Metastatic | X |
Serosa, Mesothelioma Malignant, | |
Metastatic | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + + + + + + A +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A A + + + + A + + + + A +|
Leiomyosarcoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X X X X X X|
Mesothelioma Malignant | |
Mesothelioma Malignant, Metastatic | X X |
Neoplastic Nodule | |
Bile Duct, Leiomyosarcoma, Extension,| |
Metastatic, Intestine Small | X |
__________________________________________________________________________|
Mesentery | + + + + + + + + + +|
Leiomyosarcoma, Extension, | |
Metastatic, Intestine Small | X |
Leukemia Mononuclear | X X X|
Mesothelioma Malignant | |
Mesothelioma Malignant, Metastatic | X X |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 6| 6| 4| 7| 7| 6| 4| 4| 7| 6| 6| 6| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 2| 0| 7| 9| 6| 3| 3| 6| 5| 5| 3| 3| 3| 5| 5| 2| 6| 5| 5| 5| 9| 3| 1| 0| 5|
| 3| 9| 6| 0| 6| 1| 1| 2| 5| 9| 2| 1| 8| 9| 9| 8| 8| 6| 3| 9| 2| 1| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Serosa, Glandular, Mesothelioma | |
Malignant, Metastatic | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Tooth | + + + +|
Pulp, Leukemia Mononuclear | X X X X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
Atrium, Histiocytic Sarcoma, | |
Metastatic | |
Atrium Right, Liposarcoma, | |
Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
Capsule, Mesothelioma Malignant, | |
Metastatic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X X|
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Pars Distalis, Adenoma | X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 6| 6| 4| 7| 7| 6| 4| 4| 7| 6| 6| 6| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 2| 0| 7| 9| 6| 3| 3| 6| 5| 5| 3| 3| 3| 5| 5| 2| 6| 5| 5| 5| 9| 3| 1| 0| 5|
| 3| 9| 6| 0| 6| 1| 1| 2| 5| 9| 2| 1| 8| 9| 9| 8| 8| 6| 3| 9| 2| 1| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Leukemia Mononuclear | |
Mesothelioma Malignant, Metastatic | X |
__________________________________________________________________________|
Penis | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + M + M + + +|
Adenoma | X X X X X|
Carcinoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X|
Serosa, Mesothelioma Malignant, | |
Metastatic | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X X|
Serosa, Mesothelioma Malignant, | |
Metastatic | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X X|
Tunic, Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Bronchial, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X|
Lumbar, Leukemia Mononuclear | X |
Mediastinal, Histiocytic Sarcoma, | |
Metastatic | |
Mediastinal, Leukemia Mononuclear | X X X|
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Mesothelioma Malignant, Metastatic | X X |
__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 6| 6| 4| 7| 7| 6| 4| 4| 7| 6| 6| 6| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 2| 0| 7| 9| 6| 3| 3| 6| 5| 5| 3| 3| 3| 5| 5| 2| 6| 5| 5| 5| 9| 3| 1| 0| 5|
| 3| 9| 6| 0| 6| 1| 1| 2| 5| 9| 2| 1| 8| 9| 9| 8| 8| 6| 3| 9| 2| 1| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leiomyosarcoma, Metastatic, | |
Intestine Small | X |
Leukemia Mononuclear | X X X X X X X X X|
Capsule, Mesothelioma Malignant | |
Capsule, Mesothelioma Malignant, | |
Metastatic | X X |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + M + + + + +|
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + M + + + + + + + + + + + +|
Basosquamous Tumor Malignant | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X |
Subcutaneous Tissue, Lipoma | |
Subcutaneous Tissue, Liposarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Leiomyosarcoma, Metastatic, | |
Intestine Small | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Meninges, Leukemia Mononuclear | X |
Meninges, Cerebrum, Histiocytic | |
Sarcoma, Metastatic | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | + + + + |
Leukemia Mononuclear | |
Meninges, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Zymbal's Gland| |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 6| 6| 4| 7| 7| 6| 4| 4| 7| 6| 6| 6| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 2| 0| 7| 9| 6| 3| 3| 6| 5| 5| 3| 3| 3| 5| 5| 2| 6| 5| 5| 5| 9| 3| 1| 0| 5|
| 3| 9| 6| 0| 6| 1| 1| 2| 5| 9| 2| 1| 8| 9| 9| 8| 8| 6| 3| 9| 2| 1| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Liposarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + + |
Adenoma | X |
Carcinoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
Capsule, Mesothelioma Malignant, | |
Metastatic | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Serosa, Mesothelioma Malignant, | |
Metastatic | X X |
Transitional Epithelium, Carcinoma, | |
Papillary | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X|
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 37 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 37 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 34 |
Leukemia Mononuclear | | 2 |
Colon, Serosa, Rectum, Mesothelioma | | |
Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 35 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 32 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 36 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 35 |
Leukemia Mononuclear | | 2 |
Ileum, Mesothelioma Malignant, | | |
Metastatic | | 1 |
Serosa, Mesothelioma Malignant, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 33 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M M + + + + + | 30 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 55 |
Histiocytic Sarcoma, Metastatic | | 1 |
Leukemia Mononuclear | X X X X X X X | 26 |
Mesothelioma Malignant | X | 1 |
Mesothelioma Malignant, Metastatic | | 2 |
Neoplastic Nodule | | 2 |
Bile Duct, Leiomyosarcoma, Extension,| | |
Metastatic, Intestine Small | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 16 |
Leiomyosarcoma, Extension, | | |
Metastatic, Intestine Small | | 1 |
Leukemia Mononuclear | | 4 |
Mesothelioma Malignant | X | 1 |
Mesothelioma Malignant, Metastatic | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 36 |
Leukemia Mononuclear | | 4 |
Mesothelioma Malignant, Metastatic | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 37 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 36 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 36 |
Leukemia Mononuclear | X | 2 |
Serosa, Glandular, Mesothelioma | | |
Malignant, Metastatic | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 34 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Tooth | + + | 9 |
Pulp, Leukemia Mononuclear | X X | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 38 |
Leukemia Mononuclear | X X X X X | 17 |
Atrium, Histiocytic Sarcoma, | | |
Metastatic | | 1 |
Atrium Right, Liposarcoma, | | |
Metastatic, Skin | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 37 |
Leukemia Mononuclear | X X X | 14 |
Capsule, Mesothelioma Malignant, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X | 13 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | X X X | 14 |
Bilateral, Pheochromocytoma Benign | X X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 36 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + | 54 |
Leukemia Mononuclear | X | 9 |
Pars Distalis, Adenoma | X X X X X | 9 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 38 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 3 |
C-Cell, Adenoma | | 2 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 37 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | M + + + + + + + | 34 |
Adenoma | X | 8 |
Carcinoma | | 1 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 41 |
Adenoma | | 1 |
Leukemia Mononuclear | | 4 |
Serosa, Mesothelioma Malignant, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 36 |
Leukemia Mononuclear | X | 6 |
Serosa, Mesothelioma Malignant, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | | 9 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X | 36 |
Interstitial Cell, Adenoma | X X | 13 |
Tunic, Mesothelioma Malignant | X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + | 25 |
Leukemia Mononuclear | X X X X X | 20 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 37 |
Leukemia Mononuclear | X X | 14 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 41 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 65
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Bronchial, Leukemia Mononuclear | | 1 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Inguinal, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 4 |
Mediastinal, Histiocytic Sarcoma, | | |
Metastatic | | 1 |
Mediastinal, Leukemia Mononuclear | X X X | 7 |
Pancreatic, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 38 |
Leukemia Mononuclear | X X X X | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 38 |
Leukemia Mononuclear | X X X | 15 |
Mesothelioma Malignant, Metastatic | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 52 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small | | 1 |
Leukemia Mononuclear | X X X X X X X | 26 |
Capsule, Mesothelioma Malignant | X | 1 |
Capsule, Mesothelioma Malignant, | | |
Metastatic | | 2 |
__________________________________________________________________________|____________|
Thymus | + + M + M M + + + M + + | 35 |
Leukemia Mononuclear | X X X | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + + + | 29 |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 37 |
Basosquamous Tumor Malignant | X | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
Subcutaneous Tissue, Leukemia | | |
Mononuclear | X | 4 |
Subcutaneous Tissue, Lipoma | | 1 |
Subcutaneous Tissue, Liposarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 37 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Leiomyosarcoma, Metastatic, | | |
Intestine Small | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 37 |
Leukemia Mononuclear | X | 5 |
Meninges, Leukemia Mononuclear | | 1 |
Meninges, Cerebrum, Histiocytic | | |
Sarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + + + | 13 |
Leukemia Mononuclear | | 1 |
Meninges, Leukemia Mononuclear | X | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 38 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
Histiocytic Sarcoma, Metastatic | | 1 |
Leukemia Mononuclear | X X X | 17 |
Liposarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + | 37 |
Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 37 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 4 |
Adenoma | | 1 |
Carcinoma | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X X X X | 22 |
Capsule, Mesothelioma Malignant, | | |
Metastatic | | 1 |
Renal Tubule, Adenoma | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 37 |
Leukemia Mononuclear | | 4 |
Serosa, Mesothelioma Malignant, | | |
Metastatic | | 2 |
Transitional Epithelium, Carcinoma, | | |
Papillary | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + | 55 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X | 26 |
Mesothelioma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 6| 6| 6| 6| 5| 7| 7| 6| 6| 4| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 7| 5| 5| 1| 8| 8| 7| 3| 2| 3| 2| 1| 0| 5| 0| 8| 1| 6| 5| 3| 3| 3| 0| 4|
| 8| 2| 9| 9| 8| 9| 6| 2| 1| 2| 1| 0| 2| 6| 9| 0| 2| 2| 2| 4| 2| 1| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + M + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + + + + |
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tooth | + + + |
Pulp, Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Schwannoma NOS | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
Pheochromocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 6| 6| 6| 6| 5| 7| 7| 6| 6| 4| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 7| 5| 5| 1| 8| 8| 7| 3| 2| 3| 2| 1| 0| 5| 0| 8| 1| 6| 5| 3| 3| 3| 0| 4|
| 8| 2| 9| 9| 8| 9| 6| 2| 1| 2| 1| 0| 2| 6| 9| 0| 2| 2| 2| 4| 2| 1| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X |
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 6| 6| 6| 6| 5| 7| 7| 6| 6| 4| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 7| 5| 5| 1| 8| 8| 7| 3| 2| 3| 2| 1| 0| 5| 0| 8| 1| 6| 5| 3| 3| 3| 0| 4|
| 8| 2| 9| 9| 8| 9| 6| 2| 1| 2| 1| 0| 2| 6| 9| 0| 2| 2| 2| 4| 2| 1| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X X X X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + M + + + + + + + + +|
Basal Cell Adenoma | X X |
Keratoacanthoma | X |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Rib, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + + |
Leukemia Mononuclear | X |
Osteosarcoma, Extension, Metastatic, | |
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Meninges, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spinal Cord | + |
Meninges, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X |
Osteosarcoma, Metastatic, Bone | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 6| 6| 6| 6| 5| 7| 7| 6| 6| 4| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 7| 5| 5| 1| 8| 8| 7| 3| 2| 3| 2| 1| 0| 5| 0| 8| 1| 6| 5| 3| 3| 3| 0| 4|
| 8| 2| 9| 9| 8| 9| 6| 2| 1| 2| 1| 0| 2| 6| 9| 0| 2| 2| 2| 4| 2| 1| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X|
Renal Tubule, Adenoma | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 0| 3| 0| 3| 1| 9| 8| 5| 3| 3| 3| 5| 0|
| 2| 1| 9| 9| 9| 2| 2| 2| 2| 9| 1| 0| 0| 7| 6| 1| 1| 7| 1| 9| 1| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + A + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | + + + + + + |
Pulp, Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Schwannoma NOS | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Pheochromocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 0| 3| 0| 3| 1| 9| 8| 5| 3| 3| 3| 5| 0|
| 2| 1| 9| 9| 9| 2| 2| 2| 2| 9| 1| 0| 0| 7| 6| 1| 1| 7| 1| 9| 1| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X X X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 0| 3| 0| 3| 1| 9| 8| 5| 3| 3| 3| 5| 0|
| 2| 1| 9| 9| 9| 2| 2| 2| 2| 9| 1| 0| 0| 7| 6| 1| 1| 7| 1| 9| 1| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Leukemia Mononuclear | X X |
Mediastinal, Leukemia Mononuclear | X X X X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | M M + M + M M + + M + + + + M + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Keratoacanthoma | |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Rib, Osteosarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Leukemia Mononuclear | X |
Osteosarcoma, Extension, Metastatic, | |
Bone | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Meninges, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spinal Cord | + + + + + +|
Meninges, Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X |
Osteosarcoma, Metastatic, Bone | X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | X |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 0| 3| 0| 3| 1| 9| 8| 5| 3| 3| 3| 5| 0|
| 2| 1| 9| 9| 9| 2| 2| 2| 2| 9| 1| 0| 0| 7| 6| 1| 1| 7| 1| 9| 1| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X |
Renal Tubule, Adenoma | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 0| 3| 7| 7| 5| 3| 7| 3| 9| 5| 3| 1| 5| 5| 5| | |
| 2| 1| 2| 3| 9| 2| 6| 8| 8| 9| 2| 8| 1| 6| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + A + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 55 |
Hepatocellular Adenoma | | 1 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X | 30 |
Neoplastic Nodule | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 9 |
Leukemia Mononuclear | X | 6 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + | 54 |
Leukemia Mononuclear | | 5 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 55 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 10 |
Pulp, Leukemia Mononuclear | X | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X X | 20 |
Schwannoma NOS | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 0| 3| 7| 7| 5| 3| 7| 3| 9| 5| 3| 1| 5| 5| 5| | |
| 2| 1| 2| 3| 9| 2| 6| 8| 8| 9| 2| 8| 1| 6| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X X X | 19 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X | 18 |
Pheochromocytoma Malignant | X | 3 |
Pheochromocytoma Benign | X X X | 13 |
Bilateral, Pheochromocytoma Benign | X X X | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | | 8 |
Pars Distalis, Adenoma | X X X | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X | 3 |
C-Cell, Adenoma | | 3 |
C-Cell, Carcinoma | | 3 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 3 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + | 54 |
Adenoma | X X | 7 |
Carcinoma | X X | 3 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 6 |
Bilateral, Interstitial Cell, Adenoma| X X X X X | 43 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 78
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 0| 3| 7| 7| 5| 3| 7| 3| 9| 5| 3| 1| 5| 5| 5| | |
| 2| 1| 2| 3| 9| 2| 6| 8| 8| 9| 2| 8| 1| 6| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Adenoma | X X X | 6 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + | 29 |
Leukemia Mononuclear | X X X | 21 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X | 18 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 55 |
Inguinal, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | | 2 |
Mediastinal, Leukemia Mononuclear | X X | 9 |
Pancreatic, Leukemia Mononuclear | | 4 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X X | 16 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + | 54 |
Leukemia Mononuclear | X X X | 20 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X X X X X | 31 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + M | 46 |
Leukemia Mononuclear | X | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 54 |
Basal Cell Adenoma | | 2 |
Keratoacanthoma | X | 2 |
Subcutaneous Tissue, Leukemia | | |
Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 55 |
Rib, Osteosarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 6 |
Leukemia Mononuclear | | 2 |
Osteosarcoma, Extension, Metastatic, | | |
Bone | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 05040-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 08:40:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 0| 3| 7| 7| 5| 3| 7| 3| 9| 5| 3| 1| 5| 5| 5| | |
| 2| 1| 2| 3| 9| 2| 6| 8| 8| 9| 2| 8| 1| 6| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 3 |
Meninges, Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 9 |
Meninges, Leukemia Mononuclear | X | 7 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 55 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X | 26 |
Osteosarcoma, Metastatic, Bone | | 1 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | X X | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 55 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X | 25 |
Renal Tubule, Adenoma | X X | 8 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + | 55 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + | 55 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X | 31 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
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