TDMS Study 05040-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
HYDROQUINONE
NTP Experiment-Test: 05040-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 10:19:35
Facility: American Biogenics Corp.
Chemical CAS #: 000123319
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 65 65 65
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 14 19 14
Dead 1 6 6
Gavage Death 3 3
Survivors
Terminal Sacrifice 39 27 31
Dead 1
Accident 1
Animals Examined Microscopically 55 55 55
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (53) (24) (53)
Intestine Large, Colon (55) (26) (54)
Intestine Large, Rectum (55) (28) (51)
Intestine Small, Duodenum (55) (28) (55)
Intestine Small, Ileum (54) (24) (53)
Sarcoma 1 (2%)
Intestine Small, Jejunum (54) (23) (51)
Cystadenocarcinoma 1 (2%)
Sarcoma 1 (2%)
Liver (55) (55) (55)
Mesentery (7) (13) (16)
Pheochromocytoma Malignant, Extension,
Metastatic, Adrenal Gland 1 (6%)
Pancreas (55) (28) (55)
Salivary Glands (55) (26) (55)
Stomach, Forestomach (55) (28) (54)
Stomach, Glandular (55) (28) (54)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
Tooth (3) (3) (5)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (55) (28) (55)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (55) (55) (55)
Adenoma 1 (2%)
Adrenal Gland, Medulla (54) (55) (54)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 2 (4%) 4 (7%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (53) (28) (55)
Parathyroid Gland (54) (22) (54)
Pituitary Gland (54) (54) (54)
Meningioma Malignant, Metastatic 1 (2%)
Pars Distalis, Adenoma 23 (43%) 21 (39%) 16 (30%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (55) (54) (55)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 8 (15%) 3 (6%) 5 (9%)
C-Cell, Carcinoma 4 (7%) 1 (2%) 3 (5%)
Follicular Cell, Adenocarcinoma 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (51) (24) (52)
Adenoma 4 (8%) 3 (13%) 9 (17%)
Ovary (55) (29) (55)
Granulosa Cell Tumor Malignant 1 (2%) 1 (3%)
Luteoma 1 (3%)
Oviduct (2)
Uterus (55) (55) (55)
Leiomyosarcoma 1 (2%)
Polyp Stromal 12 (22%) 5 (9%) 9 (16%)
Bilateral, Polyp Stromal 1 (2%)
Endometrium, Adenocarcinoma 1 (2%)
Endometrium, Sarcoma Stromal 1 (2%) 1 (2%)
Vagina (2) (1) (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (8) (10) (18)
Bone Marrow (55) (28) (55)
Lymph Node (55) (28) (55)
Lymph Node, Mandibular (55) (26) (52)
Lymph Node, Mesenteric (53) (28) (54)
Spleen (55) (55) (55)
Thymus (52) (27) (51)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (55) (55) (54)
Adenocarcinoma 2 (4%) 1 (2%)
Adenocarcinoma, Multiple 1 (2%)
Adenoma 2 (4%)
Fibroadenoma 28 (51%) 22 (40%) 21 (39%)
Fibroadenoma, Multiple 1 (2%) 1 (2%)
Skin (55) (30) (55)
Basal Cell Adenoma 1 (3%)
Keratoacanthoma 1 (3%) 2 (4%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (54) (28) (55)
Cartilage, Adenocarcinoma, Extension,
Metastatic, Thyroid Gland 1 (4%)
Skeletal Muscle (1) (2) (2)
Pheochromocytoma Malignant, Extension,
Metastatic, Adrenal Gland 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (55) (28) (55)
Astrocytoma Malignant 1 (4%)
Meninges, Meningioma Malignant 1 (2%)
Pons, Carcinoma, Metastatic 1 (2%)
Spinal Cord (8) (7) (12)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (55) (29) (55)
Alveolar/Bronchiolar Carcinoma 1 (3%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Nose (55) (28) (55)
Trachea (55) (28) (55)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (55) (55) (55)
Urinary Bladder (55) (27) (51)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(55) *(55) *(55)
Leukemia Mononuclear 9 (16%) 15 (27%) 22 (40%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 49 50
Total Primary Neoplasms 100 89 104
Total Animals with Benign Neoplasms 44 41 42
Total Benign Neoplasms 79 63 69
Total Animals with Malignant Neoplasms 18 24 32
Total Malignant Neoplasms 21 26 35
Total Animals with Metastatic Neoplasms 1 1 3
Total Metastatic Neoplasm 1 1 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 65 65 65
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 13 25 22
Gavage Death 2 5 7
Dead 13 7 8
Survivors
Terminal Sacrifice 27 18 18
Animals Examined Microscopically 55 55 55
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (34) (50)
Intestine Large, Colon (51) (35) (53)
Serosa, Histiocytic Sarcoma, Metastatic 1 (2%)
Intestine Large, Rectum (53) (32) (52)
Intestine Small, Duodenum (52) (35) (55)
Serosa, Ileum, Jejunum, Histiocytic Sarcoma,
Metastatic 1 (2%)
Intestine Small, Ileum (48) (33) (49)
Intestine Small, Jejunum (44) (30) (48)
Leiomyosarcoma 1 (2%) 1 (3%)
Liver (55) (55) (55)
Hepatocellular Adenoma 3 (5%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic 2 (4%) 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small 1 (2%)
Neoplastic Nodule 2 (4%) 1 (2%)
Bile Duct, Leiomyosarcoma, Extension,
Metastatic, Intestine Small 1 (2%)
Mesentery (12) (16) (9)
Histiocytic Sarcoma, Metastatic 2 (17%)
Leiomyosarcoma, Extension, Metastatic,
Intestine Small 1 (8%) 1 (6%)
Pancreas (53) (36) (54)
Histiocytic Sarcoma, Metastatic 2 (4%)
Pharynx (1)
Palate, Carcinoma, Extension, Metastatic,
Zymbal's Gland 1 (100%)
Salivary Glands (54) (37) (55)
Stomach, Forestomach (55) (36) (55)
Serosa, Glandular, Histiocytic Sarcoma,
Page 7
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Metastatic 1 (2%)
Stomach, Glandular (54) (34) (55)
Tongue (2)
Squamous Cell Papilloma 1 (50%)
Tooth (8) (9) (10)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (55) (38) (55)
Schwannoma NOS 1 (2%)
Atrium, Histiocytic Sarcoma, Metastatic 1 (3%)
Atrium Right, Liposarcoma, Metastatic, Skin 1 (3%)
Endocardium, Schwannoma NOS 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (54) (37) (54)
Histiocytic Sarcoma, Metastatic 1 (2%)
Adrenal Gland, Medulla (55) (48) (55)
Pheochromocytoma Malignant 1 (2%) 2 (4%) 3 (5%)
Pheochromocytoma Benign 9 (16%) 14 (29%) 13 (24%)
Bilateral, Pheochromocytoma Benign 4 (7%) 3 (6%) 6 (11%)
Islets, Pancreatic (54) (36) (54)
Adenoma 1 (2%) 1 (3%)
Parathyroid Gland (54) (36) (54)
Pituitary Gland (54) (54) (54)
Pars Distalis, Adenoma 13 (24%) 9 (17%) 5 (9%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (55) (38) (55)
Histiocytic Sarcoma, Metastatic 1 (2%)
C-Cell, Adenoma 5 (9%) 2 (5%) 3 (5%)
C-Cell, Carcinoma 2 (4%) 2 (5%) 3 (5%)
Follicular Cell, Adenocarcinoma 2 (4%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (2)
Epididymis (53) (37) (55)
Histiocytic Sarcoma, Metastatic 1 (2%)
Penis (1)
Preputial Gland (53) (34) (54)
Adenoma 11 (21%) 8 (24%) 7 (13%)
Carcinoma 1 (2%) 1 (3%) 3 (6%)
Histiocytic Sarcoma, Metastatic 1 (2%)
Prostate (53) (41) (55)
Adenoma 1 (2%)
Serosa, Histiocytic Sarcoma, Metastatic 1 (2%)
Seminal Vesicle (53) (36) (55)
Serosa, Histiocytic Sarcoma, Metastatic 1 (2%)
Testes (54) (54) (55)
Bilateral, Interstitial Cell, Adenoma 37 (69%) 36 (67%) 43 (78%)
Interstitial Cell, Adenoma 9 (17%) 13 (24%) 6 (11%)
Tunic, Histiocytic Sarcoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (22) (25) (29)
Histiocytic Sarcoma, Metastatic 1 (5%)
Bone Marrow (55) (37) (55)
Histiocytic Sarcoma, Metastatic 1 (2%)
Lymph Node (55) (41) (55)
Mediastinal, Histiocytic Sarcoma, Metastatic 1 (2%)
Lymph Node, Mandibular (52) (38) (54)
Lymph Node, Mesenteric (53) (38) (54)
Inguinal, Lumbar, Mediastinal, Histiocytic
Sarcoma, Metastatic 1 (2%)
Mediastinal, Mandibular, Histiocytic Sarcoma,
Metastatic 1 (2%)
Spleen (55) (52) (55)
Histiocytic Sarcoma, Metastatic 1 (2%)
Leiomyosarcoma, Metastatic, Intestine Small 1 (2%)
Capsule, Histiocytic Sarcoma, Metastatic 1 (2%)
Thymus (46) (35) (46)
Histiocytic Sarcoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (29) (53)
Adenocarcinoma 1 (2%)
Adenoma 1 (2%)
Fibroadenoma 3 (6%)
Histiocytic Sarcoma, Metastatic 1 (2%)
Skin (55) (37) (54)
Basal Cell Adenoma 2 (4%)
Basosquamous Tumor Malignant 1 (3%)
Keratoacanthoma 2 (4%) 2 (4%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (3%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (3%)
Subcutaneous Tissue, Histiocytic Sarcoma 2 (4%) 1 (3%)
Subcutaneous Tissue, Lipoma 1 (3%)
Subcutaneous Tissue, Liposarcoma 1 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (55) (37) (55)
Rib, Osteosarcoma 1 (2%)
Skeletal Muscle (4) (3) (6)
Histiocytic Sarcoma, Metastatic 1 (25%)
Leiomyosarcoma, Metastatic, Intestine Small 1 (33%)
Osteosarcoma, Extension, Metastatic, Bone 1 (17%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (55) (37) (55)
Meninges, Cerebrum, Histiocytic Sarcoma,
Metastatic 1 (3%)
Spinal Cord (13) (13) (9)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (55) (38) (55)
Alveolar/Bronchiolar Adenoma 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (3%)
Histiocytic Sarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic 2 (4%) 1 (3%)
Liposarcoma, Metastatic, Skin 1 (3%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Nose (55) (37) (55)
Page 10
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Trachea (53) (37) (55)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (2)
Canal, Carcinoma, Extension, Metastatic,
Zymbal's Gland 1 (50%)
Eye (2) (3) (4)
Harderian Gland (2) (2) (3)
Zymbal's Gland (3) (4) (1)
Adenoma 1 (25%)
Carcinoma 1 (33%) 3 (75%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (55) (55) (55)
Histiocytic Sarcoma 1 (2%)
Capsule, Histiocytic Sarcoma, Metastatic 1 (2%)
Renal Tubule, Adenoma 4 (7%) 8 (15%)
Urinary Bladder (51) (37) (55)
Serosa, Histiocytic Sarcoma, Metastatic 1 (2%)
Transitional Epithelium, Carcinoma, Papillary 1 (3%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(55) *(55) *(55)
Histiocytic Sarcoma 2 (4%) 1 (2%) 1 (2%)
Leukemia Mononuclear 28 (51%) 26 (47%) 31 (56%)
Mesothelioma Malignant 1 (2%) 3 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05040-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HYDROQUINONE Date: 09/05/94
Route: GAVAGE Time: 10:19:35
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 25 MG/KG 50 MG/KG
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 53 53 54
Total Primary Neoplasms 145 140 143
Total Animals with Benign Neoplasms 50 50 52
Total Benign Neoplasms 102 96 98
Total Animals with Malignant Neoplasms 35 37 38
Total Malignant Neoplasms 41 44 44
Total Animals with Metastatic Neoplasms 5 6 2
Total Metastatic Neoplasm 37 34 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 2 1
Total Uncertain Neoplasms 2 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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