https://ntp.niehs.nih.gov/go/3464

TDMS Study 05040-01 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: American Biogenics                                       HYDROQUINONE                                     DATE: 09/05/94       
EXPERIMENT: 05040 TEST: 01                                                                                     TIME: 10:31:31       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT:                       ROUTE: GAVAGE                                                                      NTP C#: 55834B       
PATHOLOGIST: K. SMITH                        S. EUSTIS                                                         CAS: 000123319       
------------------------------------------------------------------------------------------------------------------------------------
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: American Biogenics                                       HYDROQUINONE                                     DATE: 09/05/94      
EXPERIMENT: 05040 TEST: 01                                                                                     TIME: 10:31:31      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT:                       ROUTE: GAVAGE                                                                      NTP C#: 55834B      
PATHOLOGIST: K. SMITH                        S. EUSTIS                                                         CAS: 000123319      
                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                    ----------------
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: American Biogenics                                       HYDROQUINONE                                     DATE: 09/05/94       
EXPERIMENT: 05040 TEST: 01                                                                                     TIME: 10:31:31       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT:                       ROUTE: GAVAGE                                                                      NTP C#: 55834B       
PATHOLOGIST: K. SMITH                        S. EUSTIS                                                         CAS: 000123319       
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                          IN THE ANALYSIS OF THE STUDY OF HYDROQUINONE
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
                             Adrenal Medulla               Pheochromocytoma Benign
                                                           Pheochromocytoma: Benign, Complex, Malignant, NOS
                             Clitoral/Preputial Gland      Adenoma
                                                           Carcinoma or Adenoma
                             Kidney: Renal Tubule          Adenoma
                             Mammary Gland                 Fibroadenoma
                                                           Fibroma, Fibroadenoma or Adenoma
                                                           Fibroma, Fibroadenoma, Carcinoma, or Adenoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                                                           Carcinoma or Adenoma
                             Testes                        Adenoma
                             All Organs                    Benign Tumors
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
                             Thyroid Gland: C-Cell         Carcinoma or Adenoma
                             All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear,
                                                            or Undifferentiated
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
              ====================================================================================================
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE   1
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    13/55 (24%)     17/48 (35%)     19/55 (35%)     |     2/54 (4%)       1/55 (2%)       4/54 (7%)      |
|ADJUSTED (b)           |     39.4%           65.2%           64.7%          |      4.9%            2.1%           11.3%          |
|TERMINAL (d)           |     8/27 (30%)      6/12 (50%)      9/18 (50%)     |     1/40 (3%)       0/27 (0%)       3/32 (9%)      |
|FIRST INCIDENCE (DAYS) |      616             576             598           |      722             625             652           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.022 *       P=0.021 *       P=0.024 *      |     P=0.191         P=0.593N        P=0.256        |
|INCIDENTAL TUMOR       |     P=0.127         P=0.074         P=0.131        |     P=0.257         P=0.338N        P=0.335        |
|LOGISTIC REGRESSION    |     P=0.086         P=0.050         P=0.088        |     P=0.230         P=0.496N        P=0.310        |
|COCHRAN-ARMITAGE       |     P=0.128                                        |     P=0.238                                        |
|FISHER EXACT           |                     P=0.137         P=0.147        |                     P=0.493N        P=0.339        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/55 (2%)       2/48 (4%)       3/55 (5%)      |     1/54 (2%)       1/55 (2%)       1/54 (2%)      |
|ADJUSTED (b)           |      3.7%           12.3%           14.0%          |      2.5%            3.7%            2.9%          |
|TERMINAL (d)           |     1/27 (4%)       1/12 (8%)       2/18 (11%)     |     1/40 (3%)       1/27 (4%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      731 (T)         718             676           |      729 (T)         729 (T)         714           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.131         P=0.290         P=0.191        |     P=0.574         P=0.672         P=0.714        |
|INCIDENTAL TUMOR       |     P=0.180         P=0.354         P=0.235        |     P=0.629         P=0.672         P=0.739N       |
|LOGISTIC REGRESSION    |     P=0.163         P=0.306         P=0.241        |     P=0.599         P=0.672         P=0.741        |
|COCHRAN-ARMITAGE       |     P=0.227                                        |     P=0.640                                        |
|FISHER EXACT           |                     P=0.449         P=0.309        |                     P=0.748N        P=0.752N       |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE   2
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    14/55 (25%)     19/48 (40%)     21/55 (38%)     |     3/54 (6%)       3/55 (5%)       5/54 (9%)      |
|ADJUSTED (b)           |     42.5%           72.3%           69.7%          |      7.3%            9.4%           14.0%          |
|TERMINAL (d)           |     9/27 (33%)      7/12 (58%)     10/18 (56%)     |     2/40 (5%)       2/27 (7%)       3/32 (9%)      |
|FIRST INCIDENCE (DAYS) |      616             576             598           |      722             625             652           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.012 *       P=0.009 **      P=0.014 *      |     P=0.207         P=0.502         P=0.259        |
|INCIDENTAL TUMOR       |     P=0.084         P=0.037 *       P=0.087        |     P=0.285         P=0.655N        P=0.369        |
|LOGISTIC REGRESSION    |     P=0.055         P=0.024 *       P=0.057        |     P=0.260         P=0.629         P=0.320        |
|COCHRAN-ARMITAGE       |     P=0.096                                        |     P=0.283                                        |
|FISHER EXACT           |                     P=0.093         P=0.110        |                     P=0.652N        P=0.358        |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/53 (21%)      8/34 (24%)      7/54 (13%)     |     4/51 (8%)       3/24 (13%)      9/52 (17%)     |
|ADJUSTED (b)           |     38.5%           72.5%           26.5%          |     10.1%          100.0%           26.8%          |
|TERMINAL (d)           |    10/27 (37%)      2/3 (67%)       3/18 (17%)     |     3/38 (8%)       1/1 (100%)      8/32 (25%)     |
|FIRST INCIDENCE (DAYS) |      616             536             606           |      710             672             669           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.483N        P=0.024 *       P=0.485N       |     P=0.054         P=0.111         P=0.066        |
|INCIDENTAL TUMOR       |     P=0.332N        P=0.052         P=0.341N       |     P=0.068         P=0.254         P=0.082        |
|LOGISTIC REGRESSION    |     P=0.226N        P=0.281         P=0.289N       |     P=0.072         P=0.061         P=0.089        |
|COCHRAN-ARMITAGE       |     P=0.179N                                       |     P=0.097                                        |
|FISHER EXACT           |                     P=0.480         P=0.207N       |                     P=0.397         P=0.125        |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE   3
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/53 (2%)       1/34 (3%)       3/54 (6%)      |     0/51 (0%)       0/24 (0%)       0/52 (0%)      |
|ADJUSTED (b)           |      3.7%            3.2%            9.2%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/27 (4%)       0/3 (0%)        1/18 (6%)      |     0/38 (0%)       0/1 (0%)        0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      731 (T)         662             501           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.170         P=0.534         P=0.246        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.186         P=0.613         P=0.233        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.219         P=0.608         P=0.306        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.222                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.632         P=0.316        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/53 (21%)      9/34 (26%)     10/54 (19%)     |     4/51 (8%)       3/24 (13%)      9/52 (17%)     |
|ADJUSTED (b)           |     38.5%           73.4%           34.1%          |     10.1%          100.0%           26.8%          |
|TERMINAL (d)           |    10/27 (37%)      2/3 (67%)       4/18 (22%)     |     3/38 (8%)       1/1 (100%)      8/32 (25%)     |
|FIRST INCIDENCE (DAYS) |      616             536             501           |      710             672             669           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.325         P=0.013 *       P=0.402        |     P=0.054         P=0.111         P=0.066        |
|INCIDENTAL TUMOR       |     P=0.472         P=0.032 *       P=0.530        |     P=0.068         P=0.254         P=0.082        |
|LOGISTIC REGRESSION    |     P=0.467N        P=0.185         P=0.524N       |     P=0.072         P=0.061         P=0.089        |
|COCHRAN-ARMITAGE       |     P=0.433N                                       |     P=0.097                                        |
|FISHER EXACT           |                     P=0.357         P=0.481N       |                     P=0.397         P=0.125        |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE   4
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Schwannoma NOS                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/55 (4%)       0/38 (0%)       1/55 (2%)      |     0/55 (0%)       0/28 (0%)       0/55 (0%)      |
|ADJUSTED (b)           |      6.1%            0.0%            5.6%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/27 (4%)       0/1 (0%)        1/18 (6%)      |     0/40 (0%)       0/0             0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      637             ---             731 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.475N        P=0.492N        P=0.596N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.431N        P=0.451N        P=0.538N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.398N        P=0.383N        P=0.520N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.368N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.347N        P=0.500N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/55 (0%)       4/55 (7%)       8/55 (15%)     |     0/55 (0%)       0/55 (0%)       0/55 (0%)      |
|ADJUSTED (b)           |      0.0%           15.0%           35.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/27 (0%)       2/18 (11%)      5/18 (28%)     |     0/40 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             392             598           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.042 *       P=0.001 **     |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.002 **      P=0.048 *       P=0.003 **     |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.003 **      P=0.069         P=0.003 **     |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.003 **                                     |       (e)                                          |
|FISHER EXACT           |                     P=0.059         P=0.003 **     |                       (e)             (e)          |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE   5
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/55 (5%)       2/55 (4%)       2/55 (4%)      |     0/55 (0%)       0/55 (0%)       0/55 (0%)      |
|ADJUSTED (b)           |     10.2%           11.1%           10.1%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     2/27 (7%)       2/18 (11%)      1/18 (6%)      |     0/40 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      710             731 (T)         718           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.585N        P=0.673N        P=0.670N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.489N        P=0.618N        P=0.533N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.548N        P=0.626N        P=0.624N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.407N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/55 (2%)       0/55 (0%)       0/55 (0%)      |     0/55 (0%)       2/55 (4%)       0/55 (0%)      |
|ADJUSTED (b)           |      3.7%            0.0%            0.0%          |      0.0%            7.4%            0.0%          |
|TERMINAL (d)           |     1/27 (4%)       0/18 (0%)       0/18 (0%)      |     0/40 (0%)       2/27 (7%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      731 (T)         ---             ---           |      ---             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.334N        P=0.581N        P=0.581N       |     P=0.612         P=0.157           (e)          |
|INCIDENTAL TUMOR       |     P=0.334N        P=0.581N        P=0.581N       |     P=0.612         P=0.157           (e)          |
|LOGISTIC REGRESSION    |     P=0.334N        P=0.581N        P=0.581N       |     P=0.612         P=0.157           (e)          |
|COCHRAN-ARMITAGE       |     P=0.270N                                       |     P=0.668                                        |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                     P=0.248           (e)          |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE   6
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/55 (2%)       0/55 (0%)       0/55 (0%)      |     3/55 (5%)       0/55 (0%)       1/55 (2%)      |
|ADJUSTED (b)           |      3.7%            0.0%            0.0%          |      6.8%            0.0%            3.1%          |
|TERMINAL (d)           |     1/27 (4%)       0/18 (0%)       0/18 (0%)      |     1/40 (3%)       0/27 (0%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      731 (T)         ---             ---           |      646             ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.334N        P=0.581N        P=0.581N       |     P=0.228N        P=0.175N        P=0.371N       |
|INCIDENTAL TUMOR       |     P=0.334N        P=0.581N        P=0.581N       |     P=0.158N        P=0.070N        P=0.266N       |
|LOGISTIC REGRESSION    |     P=0.334N        P=0.581N        P=0.581N       |     P=0.183N        P=0.123N        P=0.312N       |
|COCHRAN-ARMITAGE       |     P=0.270N                                       |     P=0.176N                                       |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                     P=0.122N        P=0.309N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/55 (4%)       0/55 (0%)       0/55 (0%)      |     3/55 (5%)       2/55 (4%)       1/55 (2%)      |
|ADJUSTED (b)           |      7.4%            0.0%            0.0%          |      6.8%            7.4%            3.1%          |
|TERMINAL (d)           |     2/27 (7%)       0/18 (0%)       0/18 (0%)      |     1/40 (3%)       2/27 (7%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      731 (T)         ---             ---           |      646             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.149N        P=0.331N        P=0.331N       |     P=0.297N        P=0.641N        P=0.371N       |
|INCIDENTAL TUMOR       |     P=0.149N        P=0.331N        P=0.331N       |     P=0.235N        P=0.494N        P=0.266N       |
|LOGISTIC REGRESSION    |     P=0.149N        P=0.331N        P=0.331N       |     P=0.240N        P=0.534N        P=0.312N       |
|COCHRAN-ARMITAGE       |     P=0.096N                                       |     P=0.222N                                       |
|FISHER EXACT           |                     P=0.248N        P=0.248N       |                     P=0.500N        P=0.309N       |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE   7
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/55 (5%)       0/55 (0%)       0/55 (0%)      |    29/55 (53%)     22/55 (40%)     22/55 (40%)     |
|ADJUSTED (b)           |     11.1%            0.0%            0.0%          |     61.2%           54.9%           55.0%          |
|TERMINAL (d)           |     3/27 (11%)      0/18 (0%)       0/18 (0%)      |    22/40 (55%)     10/27 (37%)     15/32 (47%)     |
|FIRST INCIDENCE (DAYS) |      731 (T)         ---             ---           |      500             595             588           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.072N        P=0.199N        P=0.199N       |     P=0.377N        P=0.519         P=0.397N       |
|INCIDENTAL TUMOR       |     P=0.072N        P=0.199N        P=0.199N       |     P=0.116N        P=0.128N        P=0.167N       |
|LOGISTIC REGRESSION    |     P=0.072N        P=0.199N        P=0.199N       |     P=0.121N        P=0.161N        P=0.138N       |
|COCHRAN-ARMITAGE       |     P=0.037N*                                      |     P=0.106N                                       |
|FISHER EXACT           |                     P=0.122N        P=0.122N       |                     P=0.126N        P=0.126N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/55 (7%)       0/55 (0%)       0/55 (0%)      |    29/55 (53%)     23/55 (42%)     22/55 (40%)     |
|ADJUSTED (b)           |     14.8%            0.0%            0.0%          |     61.2%           57.5%           55.0%          |
|TERMINAL (d)           |     4/27 (15%)      0/18 (0%)       0/18 (0%)      |    22/40 (55%)     11/27 (41%)     15/32 (47%)     |
|FIRST INCIDENCE (DAYS) |      731 (T)         ---             ---           |      500             595             588           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.036N*       P=0.122N        P=0.122N       |     P=0.382N        P=0.439         P=0.397N       |
|INCIDENTAL TUMOR       |     P=0.036N*       P=0.122N        P=0.122N       |     P=0.119N        P=0.184N        P=0.167N       |
|LOGISTIC REGRESSION    |     P=0.036N*       P=0.122N        P=0.122N       |     P=0.122N        P=0.217N        P=0.138N       |
|COCHRAN-ARMITAGE       |     P=0.015N*                                      |     P=0.106N                                       |
|FISHER EXACT           |                     P=0.059N        P=0.059N       |                     P=0.170N        P=0.126N       |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE   8
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/55 (9%)       0/55 (0%)       0/55 (0%)      |    30/55 (55%)     23/55 (42%)     22/55 (40%)     |
|ADJUSTED (b)           |     18.5%            0.0%            0.0%          |     62.1%           57.5%           55.0%          |
|TERMINAL (d)           |     5/27 (19%)      0/18 (0%)       0/18 (0%)      |    22/40 (55%)     11/27 (41%)     15/32 (47%)     |
|FIRST INCIDENCE (DAYS) |      731 (T)         ---             ---           |      500             595             588           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.018N*       P=0.075N        P=0.075N       |     P=0.326N        P=0.496         P=0.339N       |
|INCIDENTAL TUMOR       |     P=0.018N*       P=0.075N        P=0.075N       |     P=0.081N        P=0.123N        P=0.115N       |
|LOGISTIC REGRESSION    |     P=0.018N*       P=0.075N        P=0.075N       |     P=0.087N        P=0.165N        P=0.100N       |
|COCHRAN-ARMITAGE       |     P=0.006N**                                     |     P=0.075N                                       |
|FISHER EXACT           |                     P=0.028N*       P=0.028N*      |                     P=0.126N        P=0.091N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    13/54 (24%)      9/54 (17%)      5/54 (9%)      |    23/54 (43%)     21/54 (39%)     16/54 (30%)     |
|ADJUSTED (b)           |     35.5%           35.2%           18.7%          |     50.4%           54.7%           44.5%          |
|TERMINAL (d)           |     6/27 (22%)      3/17 (18%)      1/18 (6%)      |    17/39 (44%)     11/27 (41%)     13/32 (41%)     |
|FIRST INCIDENCE (DAYS) |      459             466             598           |      476             492             492           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.125N        P=0.538N        P=0.127N       |     P=0.295N        P=0.272         P=0.300N       |
|INCIDENTAL TUMOR       |     P=0.022N*       P=0.258N        P=0.028N*      |     P=0.182N        P=0.492N        P=0.259N       |
|LOGISTIC REGRESSION    |     P=0.031N*       P=0.303N        P=0.038N*      |     P=0.108N        P=0.456N        P=0.126N       |
|COCHRAN-ARMITAGE       |     P=0.026N*                                      |     P=0.098N                                       |
|FISHER EXACT           |                     P=0.237N        P=0.034N*      |                     P=0.422N        P=0.115N       |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE   9
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    13/54 (24%)     10/54 (19%)      5/54 (9%)      |    24/54 (44%)     22/54 (41%)     16/54 (30%)     |
|ADJUSTED (b)           |     35.5%           37.0%           18.7%          |     52.6%           56.2%           44.5%          |
|TERMINAL (d)           |     6/27 (22%)      3/17 (18%)      1/18 (6%)      |    18/39 (46%)     11/27 (41%)     13/32 (41%)     |
|FIRST INCIDENCE (DAYS) |      459             466             598           |      476             492             492           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.130N        P=0.548         P=0.127N       |     P=0.247N        P=0.256         P=0.242N       |
|INCIDENTAL TUMOR       |     P=0.022N*       P=0.340N        P=0.028N*      |     P=0.133N        P=0.482N        P=0.203N       |
|LOGISTIC REGRESSION    |     P=0.033N*       P=0.392N        P=0.038N*      |     P=0.077N        P=0.463N        P=0.090N       |
|COCHRAN-ARMITAGE       |     P=0.028N*                                      |     P=0.069N                                       |
|FISHER EXACT           |                     P=0.319N        P=0.034N*      |                     P=0.423N        P=0.081N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma                                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/55 (0%)       0/55 (0%)       2/55 (4%)      |     0/55 (0%)       1/55 (2%)       0/55 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%           10.1%          |      0.0%            1.8%            0.0%          |
|TERMINAL (d)           |     0/27 (0%)       0/18 (0%)       1/18 (6%)      |     0/40 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             718           |      ---             373             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.066           (e)           P=0.161        |     P=0.730         P=0.504           (e)          |
|INCIDENTAL TUMOR       |     P=0.095           (e)           P=0.238        |     P=0.656         P=0.500           (e)          |
|LOGISTIC REGRESSION    |     P=0.070           (e)           P=0.175        |     P=0.679N        P=0.493           (e)          |
|COCHRAN-ARMITAGE       |     P=0.096                                        |     P=0.730                                        |
|FISHER EXACT           |                       (e)           P=0.248        |                     P=0.500           (e)          |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE  10
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/55 (4%)       0/55 (0%)       2/55 (4%)      |     0/55 (0%)       1/55 (2%)       2/55 (4%)      |
|ADJUSTED (b)           |      5.8%            0.0%            7.7%          |      0.0%            3.7%            6.3%          |
|TERMINAL (d)           |     1/27 (4%)       0/18 (0%)       1/18 (6%)      |     0/40 (0%)       1/27 (4%)       2/32 (6%)      |
|FIRST INCIDENCE (DAYS) |      567             ---             606           |      ---             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.559         P=0.289N        P=0.628        |     P=0.116         P=0.422         P=0.191        |
|INCIDENTAL TUMOR       |     P=0.609N        P=0.270N        P=0.685N       |     P=0.116         P=0.422         P=0.191        |
|LOGISTIC REGRESSION    |     P=0.621         P=0.236N        P=0.695        |     P=0.116         P=0.422         P=0.189        |
|COCHRAN-ARMITAGE       |     P=0.622N                                       |     P=0.142                                        |
|FISHER EXACT           |                     P=0.248N        P=0.691N       |                     P=0.500         P=0.248        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/55 (4%)       0/55 (0%)       4/55 (7%)      |     0/55 (0%)       2/55 (4%)       2/55 (4%)      |
|ADJUSTED (b)           |      5.8%            0.0%           17.2%          |      0.0%            5.5%            6.3%          |
|TERMINAL (d)           |     1/27 (4%)       0/18 (0%)       2/18 (11%)     |     0/40 (0%)       1/27 (4%)       2/32 (6%)      |
|FIRST INCIDENCE (DAYS) |      567             ---             606           |      ---             373             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.158         P=0.289N        P=0.234        |     P=0.148         P=0.199         P=0.191        |
|INCIDENTAL TUMOR       |     P=0.231         P=0.270N        P=0.349        |     P=0.118         P=0.197         P=0.191        |
|LOGISTIC REGRESSION    |     P=0.219         P=0.236N        P=0.332        |     P=0.180         P=0.262         P=0.189        |
|COCHRAN-ARMITAGE       |     P=0.222                                        |     P=0.176                                        |
|FISHER EXACT           |                     P=0.248N        P=0.339        |                     P=0.248         P=0.248        |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE  11
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/55 (4%)       2/55 (4%)       0/55 (0%)      |     0/55 (0%)       0/55 (0%)       1/55 (2%)      |
|ADJUSTED (b)           |      4.4%            8.0%            0.0%          |      0.0%            0.0%            2.9%          |
|TERMINAL (d)           |     0/27 (0%)       1/18 (6%)       0/18 (0%)      |     0/40 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      596             625             ---           |      ---             ---             711           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.202N        P=0.643         P=0.233N       |     P=0.255           (e)           P=0.468        |
|INCIDENTAL TUMOR       |     P=0.123N        P=0.697         P=0.135N       |     P=0.308           (e)           P=0.588        |
|LOGISTIC REGRESSION    |     P=0.175N        P=0.689N        P=0.250N       |     P=0.265           (e)           P=0.492        |
|COCHRAN-ARMITAGE       |     P=0.176N                                       |     P=0.270                                        |
|FISHER EXACT           |                     P=0.691N        P=0.248N       |                       (e)           P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    46/54 (85%)     49/54 (91%)     49/55 (89%)     |                                                    |
|ADJUSTED (b)           |     97.8%          100.0%          100.0%          |                                                    |
|TERMINAL (d)           |    26/27 (96%)     17/17 (100%)    18/18 (100%)    |                                                    |
|FIRST INCIDENCE (DAYS) |      483             392             522           |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.025 *       P=0.015 *       P=0.028 *      |                                                    |
|INCIDENTAL TUMOR       |     P=0.301         P=0.048 *       P=0.418        |                                                    |
|LOGISTIC REGRESSION    |     P=0.422         P=0.061         P=0.489        |                                                    |
|COCHRAN-ARMITAGE       |     P=0.315                                        |                                                    |
|FISHER EXACT           |                     P=0.278         P=0.374        |                                                    |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE  12
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/55 (9%)       2/38 (5%)       3/55 (5%)      |     9/55 (16%)      3/54 (6%)       5/55 (9%)      |
|ADJUSTED (b)           |     16.9%          100.0%           10.6%          |     21.2%           10.0%           13.9%          |
|TERMINAL (d)           |     4/27 (15%)      1/1 (100%)      1/18 (6%)      |     7/40 (18%)      2/27 (7%)       3/32 (9%)      |
|FIRST INCIDENCE (DAYS) |      637             540             581           |      674             700             676           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.458N        P=0.326         P=0.510N       |     P=0.245N        P=0.187N        P=0.322N       |
|INCIDENTAL TUMOR       |     P=0.412N        P=0.376         P=0.398N       |     P=0.161N        P=0.099N        P=0.212N       |
|LOGISTIC REGRESSION    |     P=0.303N        P=0.559N        P=0.377N       |     P=0.172N        P=0.110N        P=0.230N       |
|COCHRAN-ARMITAGE       |     P=0.284N                                       |     P=0.137N                                       |
|FISHER EXACT           |                     P=0.396N        P=0.358N       |                     P=0.066N        P=0.196N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/55 (4%)       2/38 (5%)       3/55 (5%)      |     4/55 (7%)       1/54 (2%)       3/55 (5%)      |
|ADJUSTED (b)           |      6.3%            5.5%           14.4%          |      9.4%            3.1%            9.4%          |
|TERMINAL (d)           |     1/27 (4%)       0/1 (0%)        2/18 (11%)     |     3/40 (8%)       0/27 (0%)       3/32 (9%)      |
|FIRST INCIDENCE (DAYS) |      676             610             700           |      647             709             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.296         P=0.462         P=0.356        |     P=0.511N        P=0.285N        P=0.606N       |
|INCIDENTAL TUMOR       |     P=0.412         P=0.603         P=0.467        |     P=0.453N        P=0.177N        P=0.570N       |
|LOGISTIC REGRESSION    |     P=0.388         P=0.486         P=0.434        |     P=0.448N        P=0.207N        P=0.536N       |
|COCHRAN-ARMITAGE       |     P=0.411                                        |     P=0.412N                                       |
|FISHER EXACT           |                     P=0.542         P=0.500        |                     P=0.187N        P=0.500N       |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE  13
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/55 (13%)      4/38 (11%)      6/55 (11%)     |    13/55 (24%)      4/54 (7%)       8/55 (15%)     |
|ADJUSTED (b)           |     22.7%          100.0%           24.0%          |     29.9%           12.8%           22.8%          |
|TERMINAL (d)           |     5/27 (19%)      1/1 (100%)      3/18 (17%)     |    10/40 (25%)      2/27 (7%)       6/32 (19%)     |
|FIRST INCIDENCE (DAYS) |      637             540             581           |      647             700             676           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.448         P=0.213         P=0.515        |     P=0.244N        P=0.089N        P=0.320N       |
|INCIDENTAL TUMOR       |     P=0.546N        P=0.325         P=0.559N       |     P=0.147N        P=0.027N*       P=0.207N       |
|LOGISTIC REGRESSION    |     P=0.470N        P=0.590         P=0.550N       |     P=0.153N        P=0.034N*       P=0.205N       |
|COCHRAN-ARMITAGE       |     P=0.441N                                       |     P=0.116N                                       |
|FISHER EXACT           |                     P=0.508N        P=0.500N       |                     P=0.018N*       P=0.166N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/55 (4%)       0/38 (0%)       0/55 (0%)      |     1/55 (2%)       1/54 (2%)       0/55 (0%)      |
|ADJUSTED (b)           |      6.8%            0.0%            0.0%          |      2.2%            2.6%            0.0%          |
|TERMINAL (d)           |     1/27 (4%)       0/1 (0%)        0/18 (0%)      |     0/40 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      715             ---             ---           |      685             668             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.178N        P=0.529N        P=0.331N       |     P=0.359N        P=0.717         P=0.523N       |
|INCIDENTAL TUMOR       |     P=0.125N        P=0.413N        P=0.232N       |     P=0.237N        P=0.630N        P=0.412N       |
|LOGISTIC REGRESSION    |     P=0.163N        P=0.561N        P=0.291N       |     P=0.329N        P=0.762N        P=0.498N       |
|COCHRAN-ARMITAGE       |     P=0.108N                                       |     P=0.332N                                       |
|FISHER EXACT           |                     P=0.347N        P=0.248N       |                     P=0.748         P=0.500N       |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE  14
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/55 (5%)       0/38 (0%)       1/55 (2%)      |     1/55 (2%)       2/54 (4%)       0/55 (0%)      |
|ADJUSTED (b)           |     10.4%            0.0%            3.2%          |      2.2%            6.2%            0.0%          |
|TERMINAL (d)           |     2/27 (7%)       0/1 (0%)        0/18 (0%)      |     0/40 (0%)       1/27 (4%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      715             ---             676           |      685             668             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.305N        P=0.502N        P=0.435N       |     P=0.406N        P=0.411         P=0.523N       |
|INCIDENTAL TUMOR       |     P=0.215N        P=0.392N        P=0.298N       |     P=0.309N        P=0.588         P=0.412N       |
|LOGISTIC REGRESSION    |     P=0.247N        P=0.458N        P=0.353N       |     P=0.363N        P=0.487         P=0.498N       |
|COCHRAN-ARMITAGE       |     P=0.189N                                       |     P=0.361N                                       |
|FISHER EXACT           |                     P=0.202N        P=0.309N       |                     P=0.493         P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |    12/55 (22%)      6/55 (11%)      9/55 (16%)     |
|ADJUSTED (b)           |                                                    |     27.4%           15.9%           23.3%          |
|TERMINAL (d)           |                                                    |     9/40 (23%)      2/27 (7%)       5/32 (16%)     |
|FIRST INCIDENCE (DAYS) |                                                    |      647             625             597           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.407N        P=0.270N        P=0.479N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.204N        P=0.070N        P=0.266N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.271N        P=0.114N        P=0.331N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.260N                                       |
|FISHER EXACT           |                                                    |                     P=0.098N        P=0.314N       |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE  15
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |    13/55 (24%)      7/55 (13%)      9/55 (16%)     |
|ADJUSTED (b)           |                                                    |     28.8%           17.4%           23.3%          |
|TERMINAL (d)           |                                                    |     9/40 (23%)      2/27 (7%)       5/32 (16%)     |
|FIRST INCIDENCE (DAYS) |                                                    |      501             487             597           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.324N        P=0.283N        P=0.390N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.171N        P=0.082N        P=0.221N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.187N        P=0.099N        P=0.240N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.190N                                       |
|FISHER EXACT           |                                                    |                     P=0.108N        P=0.238N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/55 (2%)       3/55 (5%)       1/55 (2%)      |     0/55 (0%)       0/55 (0%)       1/55 (2%)      |
|ADJUSTED (b)           |      2.6%           12.2%            1.9%          |      0.0%            0.0%            2.0%          |
|TERMINAL (d)           |     0/27 (0%)       1/18 (6%)       0/18 (0%)      |     0/40 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      654             653             473           |      ---             ---             590           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.543         P=0.232         P=0.758        |     P=0.276           (e)           P=0.508        |
|INCIDENTAL TUMOR       |     P=0.595N        P=0.355         P=0.741        |     P=0.366           (e)           P=0.718        |
|LOGISTIC REGRESSION    |     P=0.610         P=0.276         P=0.736        |     P=0.274           (e)           P=0.514        |
|COCHRAN-ARMITAGE       |     P=0.610                                        |     P=0.270                                        |
|FISHER EXACT           |                     P=0.309         P=0.752N       |                       (e)           P=0.500        |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE  16
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/55 (2%)       4/55 (7%)       1/55 (2%)      |     0/55 (0%)       0/55 (0%)       1/55 (2%)      |
|ADJUSTED (b)           |      2.6%           16.4%            1.9%          |      0.0%            0.0%            2.0%          |
|TERMINAL (d)           |     0/27 (0%)       1/18 (6%)       0/18 (0%)      |     0/40 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      654             653             473           |      ---             ---             590           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.505         P=0.117         P=0.758        |     P=0.276           (e)           P=0.508        |
|INCIDENTAL TUMOR       |     P=0.559N        P=0.231         P=0.741        |     P=0.366           (e)           P=0.718        |
|LOGISTIC REGRESSION    |     P=0.600         P=0.149         P=0.736        |     P=0.274           (e)           P=0.514        |
|COCHRAN-ARMITAGE       |     P=0.601                                        |     P=0.270                                        |
|FISHER EXACT           |                     P=0.182         P=0.752N       |                       (e)           P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/55 (4%)       1/55 (2%)       1/55 (2%)      |     0/55 (0%)       0/55 (0%)       0/55 (0%)      |
|ADJUSTED (b)           |      4.2%            2.4%            2.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/27 (0%)       0/18 (0%)       0/18 (0%)      |     0/40 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      459             610             554           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.370N        P=0.512N        P=0.486N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.300N        P=0.454N        P=0.465N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.388N        P=0.430N        P=0.571N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.378N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                       (e)             (e)          |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE  17
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear,                                                                              |
|     or Undifferentiated                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    28/55 (51%)     26/55 (47%)     31/55 (56%)     |     9/55 (16%)     15/55 (27%)     22/55 (40%)     |
|ADJUSTED (b)           |     71.6%           67.3%           79.9%          |     19.4%           37.9%           49.6%          |
|TERMINAL (d)           |    17/27 (63%)      7/18 (39%)     12/18 (67%)     |     4/40 (10%)      6/27 (22%)     11/32 (34%)     |
|FIRST INCIDENCE (DAYS) |      367             263             522           |      553             576             492           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.083         P=0.263         P=0.086        |     P=0.003 **      P=0.048 *       P=0.003 **     |
|INCIDENTAL TUMOR       |     P=0.317         P=0.497N        P=0.221        |     P=0.010 *       P=0.362         P=0.016 *      |
|LOGISTIC REGRESSION    |     P=0.314         P=0.488N        P=0.350        |     P=0.009 **      P=0.293         P=0.006 **     |
|COCHRAN-ARMITAGE       |     P=0.317                                        |     P=0.004 **                                     |
|FISHER EXACT           |                     P=0.424N        P=0.351        |                     P=0.124         P=0.005 **     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/55 (4%)       1/55 (2%)       1/55 (2%)      |     0/55 (0%)       0/55 (0%)       0/55 (0%)      |
|ADJUSTED (b)           |      4.2%            2.4%            2.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/27 (0%)       0/18 (0%)       0/18 (0%)      |     0/40 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      459             610             554           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.370N        P=0.512N        P=0.486N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.300N        P=0.454N        P=0.465N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.388N        P=0.430N        P=0.571N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.378N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                       (e)             (e)          |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE  18
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma Benign, Malignant, NOS                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/55 (2%)       3/55 (5%)       1/55 (2%)      |     0/55 (0%)       0/55 (0%)       0/55 (0%)      |
|ADJUSTED (b)           |      3.7%           10.2%            5.6%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/27 (4%)       1/18 (6%)       1/18 (6%)      |     0/40 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      731 (T)         392             731 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.514         P=0.227         P=0.669        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.505         P=0.277         P=0.669        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.610         P=0.319         P=0.669        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.610                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.309         P=0.752N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    50/55 (91%)     50/55 (91%)     52/55 (95%)     |    44/55 (80%)     41/55 (75%)     42/55 (76%)     |
|ADJUSTED (b)           |    100.0%           98.0%          100.0%          |     83.0%           86.8%           89.1%          |
|TERMINAL (d)           |    27/27 (100%)    17/18 (94%)     18/18 (100%)    |    31/40 (78%)     21/27 (78%)     27/32 (84%)     |
|FIRST INCIDENCE (DAYS) |      459             392             522           |      476             373             492           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.037 *       P=0.054         P=0.039 *      |     P=0.214         P=0.098         P=0.239        |
|INCIDENTAL TUMOR       |     P=0.362         P=0.279         P=0.482        |     P=0.459N        P=0.338N        P=0.514N       |
|LOGISTIC REGRESSION    |     P=0.443         P=0.338         P=0.598        |     P=0.394N        P=0.377N        P=0.438N       |
|COCHRAN-ARMITAGE       |     P=0.298                                        |     P=0.367N                                       |
|FISHER EXACT           |                     P=0.629N        P=0.358        |                     P=0.325N        P=0.409N       |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE  19
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         25 MG/KG        50 MG/KG      |      VEHICLE         25 MG/KG        50 MG/KG      |
|                       |      CONTROL                                       |      CONTROL                                       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    35/55 (64%)     37/55 (67%)     38/55 (69%)     |    18/55 (33%)     24/55 (44%)     32/55 (58%)     |
|ADJUSTED (b)           |     78.0%           82.7%           88.3%          |     36.9%           55.9%           67.1%          |
|TERMINAL (d)           |    18/27 (67%)     11/18 (61%)     14/18 (78%)     |    10/40 (25%)     10/27 (37%)     17/32 (53%)     |
|FIRST INCIDENCE (DAYS) |      367             207             473           |      501             444             458           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.077         P=0.090         P=0.087        |     P=0.004 **      P=0.041 *       P=0.004 **     |
|INCIDENTAL TUMOR       |     P=0.272         P=0.407         P=0.181        |     P=0.008 **      P=0.356         P=0.015 *      |
|LOGISTIC REGRESSION    |     P=0.307         P=0.412         P=0.346        |     P=0.008 **      P=0.183         P=0.012 *      |
|COCHRAN-ARMITAGE       |     P=0.307                                        |     P=0.005 **                                     |
|FISHER EXACT           |                     P=0.421         P=0.343        |                     P=0.163         P=0.006 **     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    53/55 (96%)     53/55 (96%)     54/55 (98%)     |    47/55 (85%)     49/55 (89%)     50/55 (91%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |     87.0%           90.7%           96.1%          |
|TERMINAL (d)           |    27/27 (100%)    18/18 (100%)    18/18 (100%)    |    33/40 (83%)     22/27 (81%)     30/32 (94%)     |
|FIRST INCIDENCE (DAYS) |      367             207             473           |      476             373             458           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.051         P=0.053         P=0.056        |     P=0.061         P=0.021 *       P=0.058        |
|INCIDENTAL TUMOR       |     P=0.367         P=0.445         P=0.414        |     P=0.208         P=0.591         P=0.259        |
|LOGISTIC REGRESSION    |     P=0.485         P=0.431         P=0.713        |     P=0.255         P=0.394         P=0.315        |
|COCHRAN-ARMITAGE       |     P=0.390                                        |     P=0.228                                        |
|FISHER EXACT           |                     P=0.691N        P=0.500        |                     P=0.388         P=0.278        |
|=================================================================================================================================|
         DATE: 09/05/94                     EXPERIMENT: 05040 TEST: 01                                                 PAGE  20
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HYDROQUINONE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
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