TDMS Study 05040-01 Pathology Tables
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
Facility: American Biogenics Corp.
Chemical CAS #: 000123319
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 0| 0| 3| 3| 3| 0| 5| 3| 3| 2| 7| 7| 3| 3| 3| 5| 4| 3| 3| 3| 2| 5|
| 1| 9| 2| 1| 0| 1| 0| 0| 2| 8| 1| 1| 9| 5| 2| 0| 0| 0| 8| 6| 1| 0| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | 2 2 2 2 2 2 3 1 3 2 2 3 |
Clear Cell Focus | 2 2 2 2 |
Congestion | |
Cytomegaly | |
Degeneration, Cystic | |
Eosinophilic Focus | |
Fatty Change | 3 1 3 |
Hematopoietic Cell Proliferation | 1 2 |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Chronic | 1 1 2 1 1 3 2 1 1 1 1 1 1 1 1 1 2 |
Inflammation, Granulomatous | 2 |
Mixed Cell Focus | 2 2 |
Necrosis, Coagulative | 3 |
Bile Duct, Hyperplasia | 2 2 2 1 1 2 1 3 2 2 1 1 2 2 1 2 2 |
Centrilobular, Atrophy | |
Sinusoid, Dilatation | 2 |
__________________________________________________________________________|
Mesentery | + |
Arteriole, Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 1 2 |
Inflammation, Chronic | 2 |
Duct, Fibrosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + |
Atrophy, Focal | |
Cytoplasmic Alteration | |
Duct, Inflammation, Chronic | 1 1 1 |
Duct, Metaplasia, Squamous | 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 2 |
Hyperkeratosis | 3 |
Hyperplasia, Papillary | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 0| 0| 3| 3| 3| 0| 5| 3| 3| 2| 7| 7| 3| 3| 3| 5| 4| 3| 3| 3| 2| 5|
| 1| 9| 2| 1| 0| 1| 0| 0| 2| 8| 1| 1| 9| 5| 2| 0| 0| 0| 8| 6| 1| 0| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 1 2 2 2 2 1 2 1 2 2 3 1 2 1 1 3 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | |
Angiectasis | 3 2 |
Degeneration, Fatty, Focal | 2 |
Degeneration, Focal | 1 |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia | 2 1 1 1 1 2 |
Hypertrophy, Focal | 1 |
Hypertrophy | |
Pigmentation, Hemosiderin | 3 |
Vacuolization Cytoplasmic | 3 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 3 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + M + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 1 3 2 1 3 3 3 2 2 3 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 3 2 3 3 4 2 2 3 3 4 3 2 2 3 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 2 2 2 1 2 4 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + M M + + + + + + + + + |
Abscess | 2 |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 0| 0| 3| 3| 3| 0| 5| 3| 3| 2| 7| 7| 3| 3| 3| 5| 4| 3| 3| 3| 2| 5|
| 1| 9| 2| 1| 0| 1| 0| 0| 2| 8| 1| 1| 9| 5| 2| 0| 0| 0| 8| 6| 1| 0| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation, Chronic | 2 2 2 1 2 |
Inflammation, Suppurative | 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 2 |
Follicle, Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + |
Cervix, Abscess | 3 3 |
Cervix, Prolapse | 3 |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 2 2 2 |
__________________________________________________________________________|
Vagina | + + |
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | |
Erythroid Cell, Hyperplasia | 3 |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + |
Pancreatic, Hematopoietic Cell | |
Proliferation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Plasma Cell | 4 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hyperplasia, Macrophage | 3 |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + M + + + + + + + + + |
Cyst | 2 |
Arteriole, Mediastinum, Inflammation,| |
Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Cyst | 4 4 3 3 2 |
Hyperplasia | 2 2 4 2 2 3 2 3 3 2 3 4 2 3 |
Duct, Fibrosis | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 0| 0| 3| 3| 3| 0| 5| 3| 3| 2| 7| 7| 3| 3| 3| 5| 4| 3| 3| 3| 2| 5|
| 1| 9| 2| 1| 0| 1| 0| 0| 2| 8| 1| 1| 9| 5| 2| 0| 0| 0| 8| 6| 1| 0| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Cyst Epithelial Inclusion | |
Ulcer | 3 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + |
Compression | X X X |
Meninges, Hemorrhage | |
Pons, Hematocyst | |
Ventricle, Dilatation | 3 |
__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Hyperplasia, Macrophage | |
Hyperplasia, Adenomatous | |
Pigmentation, Hemosiderin | |
Interstitium, Inflammation, Chronic | 1 2 |
Pleura, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 3 |
Lumen, Foreign Body | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 1 1 1 2 1 2 2 1 3 1 2 1 2 3 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 2 2 1 1 1 3 2 2 2 2 3 1 2 3 1 2 3 2 2 3 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 2 |
Glands, Cyst | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 7| 7| 7| 7| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 2| 2| 0| 0| 3| 3| 3| 0| 5| 3| 3| 2| 7| 7| 3| 3| 3| 5| 4| 3| 3| 3| 2| 5|
| 1| 9| 2| 1| 0| 1| 0| 0| 2| 8| 1| 1| 9| 5| 2| 0| 0| 0| 8| 6| 1| 0| 0| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 1 1 1 2 1 1 |
Mineralization | |
Nephropathy | 3 1 2 2 1 2 2 1 2 2 1 2 1 2 2 3 2 4 2 2 |
Pelvis, Dilatation | 2 |
Renal Tubule, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 2 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 2| 2| 5| 5| 3| 3| 2| 5| 5| 3| 3| 3| 5| 5| 3| 2| 2| 4| 5| 3| 3| 2| 7| 5|
| 9| 9| 9| 3| 8| 1| 0| 9| 8| 8| 1| 1| 1| 8| 8| 1| 9| 9| 7| 8| 1| 1| 9| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Basophilic Focus | 2 2 2 2 2 2 4 1 1 2 2 1 |
Clear Cell Focus | |
Congestion | |
Cytomegaly | |
Degeneration, Cystic | 1 |
Eosinophilic Focus | 1 |
Fatty Change | 2 2 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 1 1 1 2 1 1 2 1 1 1 1 |
Inflammation, Granulomatous | |
Mixed Cell Focus | 2 3 |
Necrosis, Coagulative | 1 |
Bile Duct, Hyperplasia | 1 2 2 1 2 2 2 1 2 2 2 1 2 2 |
Centrilobular, Atrophy | 2 1 |
Sinusoid, Dilatation | 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Arteriole, Inflammation, Chronic | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Atrophy | |
Inflammation, Chronic | |
Duct, Fibrosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Atrophy, Focal | 1 |
Cytoplasmic Alteration | 1 |
Duct, Inflammation, Chronic | 2 1 1 1 1 1 |
Duct, Metaplasia, Squamous | 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Hyperkeratosis | |
Hyperplasia, Papillary | |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 2| 2| 5| 5| 3| 3| 2| 5| 5| 3| 3| 3| 5| 5| 3| 2| 2| 4| 5| 3| 3| 2| 7| 5|
| 9| 9| 9| 3| 8| 1| 0| 9| 8| 8| 1| 1| 1| 8| 8| 1| 9| 9| 7| 8| 1| 1| 9| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 3 2 1 2 1 2 2 2 1 1 1 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | X |
Angiectasis | 4 4 3 |
Degeneration, Fatty, Focal | 2 4 2 1 |
Degeneration, Focal | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 3 |
Hypertrophy, Focal | |
Hypertrophy | 2 |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 1 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 4 2 2 2 2 1 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 1 3 3 2 2 |
Pars Intermedia, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 3 4 1 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + |
Abscess | |
Cyst | 2 3 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 2| 2| 5| 5| 3| 3| 2| 5| 5| 3| 3| 3| 5| 5| 3| 2| 2| 4| 5| 3| 3| 2| 7| 5|
| 9| 9| 9| 3| 8| 1| 0| 9| 8| 8| 1| 1| 1| 8| 8| 1| 9| 9| 7| 8| 1| 1| 9| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 3 |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + |
Atrophy | 3 |
Follicle, Cyst | 2 3 |
Periovarian Tissue, Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + |
Cervix, Abscess | |
Cervix, Prolapse | 4 |
Endometrium, Hyperplasia, Cystic | 2 2 3 |
__________________________________________________________________________|
Vagina | |
Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
Myelofibrosis | 2 |
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Pancreatic, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Plasma Cell | 3 3 3 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + |
Congestion | |
Hyperplasia, Macrophage | 2 |
Sinus, Ectasia | 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + |
Cyst | 2 3 |
Arteriole, Mediastinum, Inflammation,| |
Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + |
Cyst | 3 3 4 2 3 |
Hyperplasia | 3 2 3 2 2 2 3 2 2 1 1 1 |
Duct, Fibrosis | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 2| 2| 5| 5| 3| 3| 2| 5| 5| 3| 3| 3| 5| 5| 3| 2| 2| 4| 5| 3| 3| 2| 7| 5|
| 9| 9| 9| 3| 8| 1| 0| 9| 8| 8| 1| 1| 1| 8| 8| 1| 9| 9| 7| 8| 1| 1| 9| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Cyst Epithelial Inclusion | X |
Ulcer | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
Compression | X X |
Meninges, Hemorrhage | |
Pons, Hematocyst | 3 |
Ventricle, Dilatation | |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Hemorrhage | 2 |
Hyperplasia, Macrophage | 3 |
Hyperplasia, Adenomatous | 1 |
Pigmentation, Hemosiderin | |
Interstitium, Inflammation, Chronic | |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 2 1 |
Inflammation, Suppurative | |
Lumen, Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 2 1 2 1 1 2 1 2 2 1 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 1 2 2 2 3 1 2 2 3 1 2 2 1 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Glands, Cyst | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 2| 2| 5| 5| 3| 3| 2| 5| 5| 3| 3| 3| 5| 5| 3| 2| 2| 4| 5| 3| 3| 2| 7| 5|
| 9| 9| 9| 3| 8| 1| 0| 9| 8| 8| 1| 1| 1| 8| 8| 1| 9| 9| 7| 8| 1| 1| 9| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 1 2 |
Mineralization | 1 1 |
Nephropathy | 4 2 2 2 3 2 3 1 3 3 3 2 3 1 |
Pelvis, Dilatation | |
Renal Tubule, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 2| 1| 8| 3| 3| 3| 3| 2| 3| 2| 8| 7| 5| | |
| 1| 0| 9| 0| 6| 1| 0| 0| 0| 9| 1| 9| 5| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + A + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + | 54 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 55 |
Basophilic Focus | 3 1 3 2 2 3 | 30 2.1|
Clear Cell Focus | 1 | 5 1.8|
Congestion | 4 | 1 4.0|
Cytomegaly | 3 | 1 3.0|
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | | 1 1.0|
Fatty Change | 2 2 2 | 9 2.1|
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | X | 9 |
Inflammation, Chronic | 2 1 1 1 1 1 1 1 1 2 | 39 1.2|
Inflammation, Granulomatous | | 1 2.0|
Mixed Cell Focus | | 4 2.3|
Necrosis, Coagulative | 2 3 | 4 2.3|
Bile Duct, Hyperplasia | 1 1 2 2 1 3 2 2 2 1 | 41 1.7|
Centrilobular, Atrophy | 2 4 | 4 2.3|
Sinusoid, Dilatation | | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Arteriole, Inflammation, Chronic | 4 | 1 4.0|
Fat, Necrosis | 2 4 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 55 |
Atrophy | | 2 1.5|
Inflammation, Chronic | | 1 2.0|
Duct, Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 55 |
Atrophy, Focal | | 1 1.0|
Cytoplasmic Alteration | 1 2 | 3 1.3|
Duct, Inflammation, Chronic | 1 1 1 1 | 13 1.1|
Duct, Metaplasia, Squamous | | 5 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 2| 1| 8| 3| 3| 3| 3| 2| 3| 2| 8| 7| 5| | |
| 1| 0| 9| 0| 6| 1| 0| 0| 0| 9| 1| 9| 5| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 55 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 3.0|
Hyperplasia, Papillary | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Ulcer | 3 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Tooth | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 55 |
Cardiomyopathy | 2 1 1 1 1 2 2 2 2 2 2 1 | 46 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 55 |
Accessory Adrenal Cortical Nodule | | 1 |
Angiectasis | | 5 3.2|
Degeneration, Fatty, Focal | 2 1 1 | 8 1.9|
Degeneration, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia | 1 | 10 1.6|
Hypertrophy, Focal | | 1 1.0|
Hypertrophy | | 1 2.0|
Pigmentation, Hemosiderin | | 1 3.0|
Vacuolization Cytoplasmic | | 3 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 54 |
Hyperplasia | 2 2 | 13 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 53 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + | 54 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + A + + + + | 54 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | 1 2 2 1 1 3 | 23 2.1|
Pars Distalis, Hemorrhage | 4 | 1 4.0|
Pars Distalis, Hyperplasia | 1 3 2 2 1 2 | 28 2.4|
Pars Intermedia, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 2| 1| 8| 3| 3| 3| 3| 2| 3| 2| 8| 7| 5| | |
| 1| 0| 9| 0| 6| 1| 0| 0| 0| 9| 1| 9| 5| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia | 3 3 | 19 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + M + + + + | 51 |
Abscess | | 1 2.0|
Cyst | 2 | 4 2.3|
Hyperplasia | 3 | 2 3.0|
Inflammation, Chronic | 2 | 7 1.7|
Inflammation, Suppurative | 2 2 | 5 1.4|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + | 55 |
Atrophy | | 2 2.5|
Follicle, Cyst | | 2 2.5|
Periovarian Tissue, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 55 |
Cervix, Abscess | | 2 3.0|
Cervix, Prolapse | | 2 3.5|
Endometrium, Hyperplasia, Cystic | 2 2 2 4 2 4 | 17 2.4|
__________________________________________________________________________|____________|
Vagina | | 2 |
Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + | 8 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 55 |
Myelofibrosis | | 1 2.0|
Erythroid Cell, Hyperplasia | | 1 3.0|
Myeloid Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 55 |
Pancreatic, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 55 |
Hyperplasia, Plasma Cell | | 4 3.3|
Sinus, Ectasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + | 53 |
Congestion | 4 | 1 4.0|
Hyperplasia, Macrophage | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 2| 1| 8| 3| 3| 3| 3| 2| 3| 2| 8| 7| 5| | |
| 1| 0| 9| 0| 6| 1| 0| 0| 0| 9| 1| 9| 5| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Sinus, Ectasia | 3 2 1 2 | 6 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 55 |
Hematopoietic Cell Proliferation | | 2 3.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + | 52 |
Cyst | 2 | 4 2.3|
Arteriole, Mediastinum, Inflammation,| | |
Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + | 55 |
Cyst | 3 4 3 4 3 4 | 16 3.3|
Hyperplasia | 3 2 2 3 3 3 3 2 1 2 | 36 2.4|
Duct, Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 55 |
Cyst Epithelial Inclusion | | 1 |
Ulcer | | 2 2.5|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 55 |
Compression | X X | 7 |
Meninges, Hemorrhage | 1 | 1 1.0|
Pons, Hematocyst | | 1 3.0|
Ventricle, Dilatation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 55 |
Hemorrhage | | 1 2.0|
Hyperplasia, Macrophage | | 1 3.0|
Hyperplasia, Adenomatous | | 1 1.0|
Pigmentation, Hemosiderin | 1 | 1 1.0|
Interstitium, Inflammation, Chronic | 1 | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 4| | |
DAY ON TEST | 3| 3| 2| 1| 8| 3| 3| 3| 3| 2| 3| 2| 8| 7| 5| | |
| 1| 0| 9| 0| 6| 1| 0| 0| 0| 9| 1| 9| 5| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
VEHICLE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Pleura, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 55 |
Inflammation, Chronic | 3 2 2 | 7 2.0|
Inflammation, Suppurative | | 1 3.0|
Lumen, Foreign Body | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 1 2 3 2 2 2 2 | 39 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | 3 2 3 2 2 3 3 3 2 2 3 3 2 2 | 52 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 55 |
Inflammation, Chronic | | 3 1.3|
Glands, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Retina, Atrophy | | 2 3.5|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Chronic | | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 55 |
Inflammation, Chronic | 1 1 1 1 | 17 1.2|
Mineralization | 1 | 3 1.0|
Nephropathy | 2 2 2 2 1 2 2 2 1 2 1 2 1 | 47 2.0|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Inflammation, | | |
Suppurative | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 55 |
Inflammation, Chronic | | 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 2| 7| 5| 5| 7| 3| 3| 3| 9| 8| 3| 2| 5| 5| 5| 3| 3| 3| 3| 7| 3| 2| 6| 5| 2|
| 1| 2| 8| 8| 3| 1| 0| 0| 5| 7| 1| 4| 8| 8| 8| 1| 1| 1| 0| 6| 0| 9| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 1 2 1 1 2 2 2 4 4 2 2 3 |
Clear Cell Focus | 2 2 |
Congestion | 2 |
Cytomegaly | |
Degeneration, Cystic | |
Eosinophilic Focus | |
Fatty Change | 2 3 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X X|
Inflammation, Chronic | 1 2 2 1 1 1 1 2 2 2 1 1 1|
Mineralization | |
Mixed Cell Focus | |
Necrosis, Coagulative | 3 |
Bile Duct, Hyperplasia | 1 2 2 1 1 2 1 2 3 3 1 1 2 2|
Centrilobular, Atrophy | 4 3 |
Sinusoid, Dilatation | 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Arteriole, Degeneration, Hyaline | |
Arteriole, Inflammation, Chronic | |
Fat, Inflammation, Chronic | 1 2 |
Fat, Inflammation, Granulomatous | 2 |
Fat, Mineralization | |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + +|
Atrophy | |
Duct, Necrosis, Coagulative | |
__________________________________________________________________________|
Pharynx | |
Hyperkeratosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + +|
Atrophy, Focal | |
Duct, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 2| 7| 5| 5| 7| 3| 3| 3| 9| 8| 3| 2| 5| 5| 5| 3| 3| 3| 3| 7| 3| 2| 6| 5| 2|
| 1| 2| 8| 8| 3| 1| 0| 0| 5| 7| 1| 4| 8| 8| 8| 1| 1| 1| 0| 6| 0| 9| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Duct, Inflammation, Chronic | |
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 3 |
Inflammation, Acute | 4 |
Ulcer | 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + +|
Inflammation, Acute | 4 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 2 1 2 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Cyst | |
Degeneration, Fatty, Focal | 1 4 1|
Hematopoietic Cell Proliferation | 2 1 |
Hyperplasia | 1 4 3 1|
Hypertrophy | |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 2 |
Capsule, Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Cyst | 2|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 1 3 2 2 3 |
Pars Distalis, Hyperplasia | 3 3 3 1 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 4 3 3 3|
Follicle, Cyst | 1 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 2| 7| 5| 5| 7| 3| 3| 3| 9| 8| 3| 2| 5| 5| 5| 3| 3| 3| 3| 7| 3| 2| 6| 5| 2|
| 1| 2| 8| 8| 3| 1| 0| 0| 5| 7| 1| 4| 8| 8| 8| 1| 1| 1| 0| 6| 0| 9| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + M M + + + + +|
Cyst | |
Hyperplasia | |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + +|
Atrophy | |
Corpus Luteum, Cyst | |
Follicle, Cyst | |
Periovarian Tissue, Cyst | 4|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Cervix, Abscess | 3 3|
Cervix, Inflammation, Proliferative | |
Endometrium, Hyperplasia, Cystic | 2 2 |
__________________________________________________________________________|
Vagina | +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Neutrophilia | |
Thrombocytopenia | |
Erythrocyte, Poikilocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + +|
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Sinus, Ectasia | |
Pancreatic, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + +|
Hyperplasia, Macrophage | 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + +|
Hemorrhage | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 3|
Infarct | |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 2| 7| 5| 5| 7| 3| 3| 3| 9| 8| 3| 2| 5| 5| 5| 3| 3| 3| 3| 7| 3| 2| 6| 5| 2|
| 1| 2| 8| 8| 3| 1| 0| 0| 5| 7| 1| 4| 8| 8| 8| 1| 1| 1| 0| 6| 0| 9| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + +|
Cyst | 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 4 3 4|
Hyperplasia | 2 3 1 2 3 2 2 2 3 2 1 2 3 2 3 |
Mineralization | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + +|
Abscess | 3 |
Cyst Epithelial Inclusion | |
Inflammation, Chronic | 2 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + +|
Compression | X X X |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Macrophage | 3 |
Hyperplasia, Adenomatous | |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + +|
Exudate | |
Inflammation, Chronic | 3 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 2 2 1|
Nasolacrimal Duct, Metaplasia, | |
Squamous | 3 1 2 1 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + +|
Inflammation, Chronic | |
Glands, Cyst | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6|
DAY ON TEST | 2| 7| 5| 5| 7| 3| 3| 3| 9| 8| 3| 2| 5| 5| 5| 3| 3| 3| 3| 7| 3| 2| 6| 5| 2|
| 1| 2| 8| 8| 3| 1| 0| 0| 5| 7| 1| 4| 8| 8| 8| 1| 1| 1| 0| 6| 0| 9| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation, Chronic | |
__________________________________________________________________________|
Zymbal's Gland | M |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 2 1 1|
Mineralization | |
Nephropathy | 4 2 1 2 1 3 2 2 1 2 1 2 3 1 2|
Pelvis, Dilatation | |
Transitional Epithelium, Hyperplasia,| |
Papillary | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 1| 0| 5| 3| 3| 2| 1| 4| 2| 2| 0| 5| 3| 2| 0| 0| 5| 5|
| 1| 1| 5| 4| 0| 1| 1| 9| 0| 8| 1| 0| 9| 0| 4| 9| 9| 8| 5| 3| 9| 0| 0| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + A + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 4 3 3 3 3 2 3 3 4 2 4 1 3 3 3 2 3|
Clear Cell Focus | 3 X 3 |
Congestion | |
Cytomegaly | 1 |
Degeneration, Cystic | 2 |
Eosinophilic Focus | 3 2 |
Fatty Change | 2 2 2 2 2 2 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | 2 1 2 2 1 1 2 1 1|
Mineralization | 1 1 3 |
Mixed Cell Focus | 4 |
Necrosis, Coagulative | 1 2 |
Bile Duct, Hyperplasia | 2 3 3 2 1 1 2 2 2 1 1 1|
Centrilobular, Atrophy | |
Sinusoid, Dilatation | |
__________________________________________________________________________|
Mesentery | + + + + + +|
Arteriole, Degeneration, Hyaline | |
Arteriole, Inflammation, Chronic | |
Fat, Inflammation, Chronic | 1 3 4 |
Fat, Inflammation, Granulomatous | |
Fat, Mineralization | 1|
Fat, Necrosis | 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + +|
Atrophy | 1 |
Duct, Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Pharynx | M + |
Hyperkeratosis | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + M + + + + + + + + +|
Atrophy, Focal | |
Duct, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 1| 0| 5| 3| 3| 2| 1| 4| 2| 2| 0| 5| 3| 2| 0| 0| 5| 5|
| 1| 1| 5| 4| 0| 1| 1| 9| 0| 8| 1| 0| 9| 0| 4| 9| 9| 8| 5| 3| 9| 0| 0| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Duct, Inflammation, Chronic | |
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Acute | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 1 1 2 2 1|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | |
Degeneration, Fatty, Focal | 4 3 2 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 1 2 3 2|
Hypertrophy | |
Necrosis, Coagulative | 2 3 |
Vacuolization Cytoplasmic | |
Capsule, Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + M + + M + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Cyst | 2 2 2 1 2 3 2 3 2 2 3|
Pars Distalis, Hyperplasia | 4 4 2 3 3 3 3 4 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 3 3 2 2 3 1 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 1| 0| 5| 3| 3| 2| 1| 4| 2| 2| 0| 5| 3| 2| 0| 0| 5| 5|
| 1| 1| 5| 4| 0| 1| 1| 9| 0| 8| 1| 0| 9| 0| 4| 9| 9| 8| 5| 3| 9| 0| 0| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M M + M + M M + + + + +|
Cyst | 2 |
Hyperplasia | 3 2 |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + +|
Atrophy | |
Corpus Luteum, Cyst | 1 |
Follicle, Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Cervix, Abscess | 3 3 |
Cervix, Inflammation, Proliferative | |
Endometrium, Hyperplasia, Cystic | 2 2 3 2 3 3 2 2 2 2 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + |
Neutrophilia | 2 |
Thrombocytopenia | 3 |
Erythrocyte, Poikilocytosis | 3 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Plasma Cell| 2 |
Mediastinal, Sinus, Ectasia | 1 |
Pancreatic, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + +|
Hyperplasia, Macrophage | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + +|
Hemorrhage | 3|
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3|
Infarct | 4 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 1| 0| 5| 3| 3| 2| 1| 4| 2| 2| 0| 5| 3| 2| 0| 0| 5| 5|
| 1| 1| 5| 4| 0| 1| 1| 9| 0| 8| 1| 0| 9| 0| 4| 9| 9| 8| 5| 3| 9| 0| 0| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Hemosiderin | 4 2 |
__________________________________________________________________________|
Thymus | + + + + + M M + M + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 |
Hyperplasia | 3 3 2 3 2 2 3 2 3 4 2 2 2 3 3 2 1 3 2 2|
Mineralization | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + +|
Abscess | |
Cyst Epithelial Inclusion | X |
Inflammation, Chronic | |
Ulcer | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + +|
Compression | X X |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + +|
Congestion | 4 |
Hyperplasia, Macrophage | |
Hyperplasia, Adenomatous | |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + +|
Exudate | X |
Inflammation, Chronic | 2 2|
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 1 1 1 1 1 2 2 1 2 1|
Nasolacrimal Duct, Metaplasia, | |
Squamous | 2 2 2 2 2 2 2 2 2 1 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
Glands, Cyst | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6|
DAY ON TEST | 3| 3| 2| 2| 6| 3| 3| 1| 0| 5| 3| 3| 2| 1| 4| 2| 2| 0| 5| 3| 2| 0| 0| 5| 5|
| 1| 1| 5| 4| 0| 1| 1| 9| 0| 8| 1| 0| 9| 0| 4| 9| 9| 8| 5| 3| 9| 0| 0| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 1 1 1 1 1 1 2 |
Mineralization | 1 |
Nephropathy | 2 2 2 2 3 2 1 1 1 2 3 2 3 1 3 1 3 2 2 3 1|
Pelvis, Dilatation | 3 |
Transitional Epithelium, Hyperplasia,| |
Papillary | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 2| 6| 5| 5| 3| 3| 0| 9| 5| 2| 2| 2| 7| 6| | |
| 0| 9| 8| 8| 8| 0| 0| 9| 2| 8| 9| 9| 9| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + | 28 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 23 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 55 |
Basophilic Focus | 2 3 2 3 2 3 1 1 | 38 2.5|
Clear Cell Focus | 2 | 6 2.4|
Congestion | | 1 2.0|
Cytomegaly | 2 | 2 1.5|
Degeneration, Cystic | | 1 2.0|
Eosinophilic Focus | | 2 2.5|
Fatty Change | 4 2 | 10 2.3|
Focal Cellular Change | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Hemorrhage | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 10 |
Inflammation, Chronic | 2 1 1 2 1 1 2 1 | 30 1.4|
Mineralization | | 3 1.7|
Mixed Cell Focus | | 1 4.0|
Necrosis, Coagulative | | 3 2.0|
Bile Duct, Hyperplasia | 3 2 2 2 1 1 2 3 2 2 | 36 1.8|
Centrilobular, Atrophy | 2 | 3 3.0|
Sinusoid, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 13 |
Arteriole, Degeneration, Hyaline | 2 | 1 2.0|
Arteriole, Inflammation, Chronic | 2 | 1 2.0|
Fat, Inflammation, Chronic | 2 | 6 2.2|
Fat, Inflammation, Granulomatous | | 1 2.0|
Fat, Mineralization | | 1 1.0|
Fat, Necrosis | 2 | 5 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 28 |
Atrophy | | 1 1.0|
Duct, Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 2| 6| 5| 5| 3| 3| 0| 9| 5| 2| 2| 2| 7| 6| | |
| 0| 9| 8| 8| 8| 0| 0| 9| 2| 8| 9| 9| 9| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 26 |
Atrophy, Focal | 2 | 1 2.0|
Duct, Ectasia | 2 | 1 2.0|
Duct, Inflammation, Chronic | 1 | 1 1.0|
Duct, Metaplasia, Squamous | 1 | 3 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + | 28 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 28 |
Acanthosis | 2 | 2 2.5|
Hyperkeratosis | 2 | 2 2.5|
Inflammation, Acute | | 1 4.0|
Ulcer | | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 28 |
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 28 |
Cardiomyopathy | 1 2 | 20 1.6|
Atrium, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 55 |
Angiectasis | 3 3 3 | 6 3.0|
Cyst | 2 | 1 2.0|
Degeneration, Fatty, Focal | 2 | 8 2.3|
Hematopoietic Cell Proliferation | | 2 1.5|
Hyperplasia | 1 3 | 11 2.1|
Hypertrophy | 2 | 1 2.0|
Necrosis, Coagulative | 3 | 3 2.7|
Vacuolization Cytoplasmic | | 1 2.0|
Capsule, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 55 |
Hyperplasia | 1 1 3 1 | 8 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 28 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M M + | 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 2| 6| 5| 5| 3| 3| 0| 9| 5| 2| 2| 2| 7| 6| | |
| 0| 9| 8| 8| 8| 0| 0| 9| 2| 8| 9| 9| 9| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 54 |
Cyst | | 1 2.0|
Pars Distalis, Angiectasis | | 2 3.5|
Pars Distalis, Cyst | 4 3 | 18 2.3|
Pars Distalis, Hyperplasia | 2 2 2 2 | 22 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 54 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 1 4 2 2 | 15 2.5|
Follicle, Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 24 |
Cyst | | 1 2.0|
Hyperplasia | | 2 2.5|
Inflammation, Chronic | | 2 1.0|
Inflammation, Granulomatous | 3 | 1 3.0|
Inflammation, Suppurative | 1 | 1 1.0|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + | 29 |
Atrophy | 3 | 1 3.0|
Corpus Luteum, Cyst | | 1 1.0|
Follicle, Cyst | 4 | 1 4.0|
Periovarian Tissue, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + | 55 |
Inflammation, Suppurative | | 1 2.0|
Cervix, Abscess | 4 3 | 6 3.2|
Cervix, Inflammation, Proliferative | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3 3 4 | 16 2.4|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 10 |
Neutrophilia | X | 2 2.0|
Thrombocytopenia | | 1 3.0|
Erythrocyte, Poikilocytosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 2| 6| 5| 5| 3| 3| 0| 9| 5| 2| 2| 2| 7| 6| | |
| 0| 9| 8| 8| 8| 0| 0| 9| 2| 8| 9| 9| 9| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 28 |
Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 28 |
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Mediastinal, Sinus, Ectasia | | 1 1.0|
Pancreatic, Sinus, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + | 26 |
Hyperplasia, Macrophage | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 28 |
Hemorrhage | | 1 3.0|
Sinus, Ectasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 55 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 5 2.6|
Infarct | | 1 4.0|
Inflammation, Chronic | | 1 1.0|
Pigmentation, Hemosiderin | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M M M + + | 27 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 55 |
Cyst | 2 4 | 12 3.1|
Hyperplasia | 2 2 2 4 3 3 2 3 2 3 | 45 2.4|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 30 |
Abscess | | 1 3.0|
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic | | 2 2.0|
Ulcer | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 28 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 28 |
Compression | X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 2| 6| 5| 5| 3| 3| 0| 9| 5| 2| 2| 2| 7| 6| | |
| 0| 9| 8| 8| 8| 0| 0| 9| 2| 8| 9| 9| 9| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
25 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | + | 7 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 29 |
Congestion | | 2 3.5|
Hyperplasia, Macrophage | | 1 3.0|
Hyperplasia, Adenomatous | 2 | 1 2.0|
Interstitium, Inflammation, Chronic | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 28 |
Exudate | | 1 |
Inflammation, Chronic | 2 | 4 2.3|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 3 2 | 17 1.5|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | 3 3 | 20 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + | 28 |
Inflammation, Chronic | | 2 1.5|
Glands, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 55 |
Cyst | 3 | 1 3.0|
Inflammation, Chronic | 2 1 1 2 | 14 1.3|
Mineralization | | 1 1.0|
Nephropathy | 3 2 2 2 2 3 2 1 2 1 3 | 47 2.0|
Pelvis, Dilatation | | 1 3.0|
Transitional Epithelium, Hyperplasia,| | |
Papillary | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 27 |
Inflammation, Chronic | 1 | 4 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 3| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 9| 8| 5| 3| 3| 3| 5| 5| 1| 5| 3| 5| 4| 3| 3| 2| 5| 9| 3| 3| 2| 5| 5|
| 9| 9| 5| 7| 8| 1| 1| 0| 8| 8| 6| 8| 8| 8| 3| 0| 0| 9| 2| 8| 1| 0| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + M A M + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
Erosion | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | 2 3 1 1 3 2 2 3 2 3 1 2 1 |
Clear Cell Focus | 3 1 |
Congestion | |
Cytomegaly | 3 |
Fatty Change | 3 1 2 |
Fibrosis, Focal | 2 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X |
Hyperplasia, Focal | 2 |
Inflammation, Chronic | 2 1 2 1 1 1 1 1 1 2 1 1 |
Inflammation, Granulomatous | 1 |
Mineralization | |
Mixed Cell Focus | 1 2 |
Necrosis, Coagulative | 3 2 |
Arteriole, Inflammation, | |
Proliferative | |
Bile Duct, Hyperplasia | 2 3 1 2 1 2 2 2 1 2 1 2 1 3 1 1 |
Centrilobular, Atrophy | 2 4 3 |
Sinusoid, Dilatation | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Pigmentation, Hemosiderin | |
Fat, Hemorrhage | |
Fat, Inflammation, Acute | |
Fat, Inflammation, Chronic | 2 |
Fat, Necrosis | 2 2 1 2 |
Fat, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Focal Cellular Change | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Atrophy, Focal | |
Cytoplasmic Alteration | 1 1 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 3| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 9| 8| 5| 3| 3| 3| 5| 5| 1| 5| 3| 5| 4| 3| 3| 2| 5| 9| 3| 3| 2| 5| 5|
| 9| 9| 5| 7| 8| 1| 1| 0| 8| 8| 6| 8| 8| 8| 3| 0| 0| 9| 2| 8| 1| 0| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Arteriole, Inflammation, | |
Proliferative | |
Duct, Inflammation, Chronic | 2 |
Duct, Metaplasia, Squamous | 2 2 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 3 1 2 2 2 2 2 1 2 1 1 1 1 1 1 1 |
Atrium, Inflammation, Chronic | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | X |
Angiectasis | 3 3 1 |
Atrophy | |
Cyst | |
Degeneration, Fatty, Focal | 2 3 |
Degeneration, Focal | |
Hematopoietic Cell Proliferation | 2 1 |
Hyperplasia | 2 1 1 3 2 |
Vacuolization Cytoplasmic | 3 2 |
Capsule, Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 3 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + |
Hyperplasia | 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
Pars Distalis, Cyst | 3 X 3 3 2 3 3 4 |
Pars Distalis, Hyperplasia | 3 3 3 4 2 3 2 3 4 4 3 4 |
Rathke's Cleft, Crystals | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 1 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 3| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 9| 8| 5| 3| 3| 3| 5| 5| 1| 5| 3| 5| 4| 3| 3| 2| 5| 9| 3| 3| 2| 5| 5|
| 9| 9| 5| 7| 8| 1| 1| 0| 8| 8| 6| 8| 8| 8| 3| 0| 0| 9| 2| 8| 1| 0| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + M + + + M + + + + + |
Cyst | 3 2 3 3 |
Inflammation, Chronic | 2 2 2 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | 1 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + |
Corpus Luteum, Cyst | |
Periovarian Tissue, Cyst | 3 |
__________________________________________________________________________|
Oviduct | + + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | |
Cervix, Abscess | 3 |
Cervix, Inflammation, Proliferative | |
Cervix, Epithelium, Degeneration, | |
Mucoid | |
Endometrium, Hyperplasia, Cystic | 2 3 2 2 2 2 3 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Erythroid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Hyperplasia, Macrophage | 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + M + + + + + + + + + |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + |
Congestion | 4 |
Hyperplasia, Plasma Cell | 3 |
Sinus, Ectasia | 2 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | |
Hematopoietic Cell Proliferation | 4 2 |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + |
Cyst | 2 2 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 3| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 9| 8| 5| 3| 3| 3| 5| 5| 1| 5| 3| 5| 4| 3| 3| 2| 5| 9| 3| 3| 2| 5| 5|
| 9| 9| 5| 7| 8| 1| 1| 0| 8| 8| 6| 8| 8| 8| 3| 0| 0| 9| 2| 8| 1| 0| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + |
Abscess | 1 |
Cyst | 4 4 4 3 |
Hyperplasia | 3 2 2 3 2 2 4 2 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | X |
Ulcer | 3 |
Subcutaneous Tissue, Cyst | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Compression | |
Cerebrum, Mineralization | 1 |
Ventricle, Dilatation | |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Edema | 2 |
Hyperplasia, Macrophage | 2 |
Hyperplasia, Adenomatous | 2 2 |
Interstitium, Inflammation, Chronic | 1 |
Interstitium, Inflammation, | |
Granulomatous | 2 |
Pleura, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Inflammation, Chronic | 3 3 2 |
Nasolacrimal Duct, Cyst | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 1 2 2 2 2 2 1 1 2 2 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 3 3 2 3 3 2 2 2 4 3 3 1 1 4 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
Glands, Cyst | 2 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | |
Cornea, Proliferation | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 6| 4| 7| 6| 6| 4| 3| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 2| 2| 9| 8| 5| 3| 3| 3| 5| 5| 1| 5| 3| 5| 4| 3| 3| 2| 5| 9| 3| 3| 2| 5| 5|
| 9| 9| 5| 7| 8| 1| 1| 0| 8| 8| 6| 8| 8| 8| 3| 0| 0| 9| 2| 8| 1| 0| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Cyst | 2 |
Inflammation, Chronic | 1 2 1 1 1 1 1 |
Mineralization | 2 1 1 |
Necrosis, Coagulative | |
Nephropathy | 2 1 4 1 1 2 1 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + + + + + + + M + + + + |
Inflammation, Chronic | 1 1 |
Transitional Epithelium, Hyperplasia,| |
Papillary | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 5| 4| 4|
DAY ON TEST | 2| 1| 1| 9| 3| 2| 0| 5| 5| 5| 3| 3| 3| 3| 9| 3| 3| 2| 2| 5| 0| 6| 8| 5| 5|
| 9| 4| 1| 4| 4| 9| 7| 8| 8| 8| 1| 0| 0| 0| 7| 0| 0| 9| 9| 8| 3| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
Erosion | 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | 2 2 1 2 1 3 1 |
Clear Cell Focus | X |
Congestion | |
Cytomegaly | 2 |
Fatty Change | 2 2 2 |
Fibrosis, Focal | |
Focal Cellular Change | 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia, Focal | |
Inflammation, Chronic | 1 1 1 3 1 1 1 2 1 |
Inflammation, Granulomatous | |
Mineralization | |
Mixed Cell Focus | |
Necrosis, Coagulative | 3 |
Arteriole, Inflammation, | |
Proliferative | 3 |
Bile Duct, Hyperplasia | 1 2 2 3 2 2 3 3 4 1 2 2 |
Centrilobular, Atrophy | 1 2 3 2 2 |
Sinusoid, Dilatation | 2 1 |
__________________________________________________________________________|
Mesentery | M + + + + + + + |
Pigmentation, Hemosiderin | |
Fat, Hemorrhage | 3 |
Fat, Inflammation, Acute | 4 |
Fat, Inflammation, Chronic | 1 2 |
Fat, Necrosis | 2 2 |
Fat, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Focal Cellular Change | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Atrophy, Focal | 2 |
Cytoplasmic Alteration | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 5| 4| 4|
DAY ON TEST | 2| 1| 1| 9| 3| 2| 0| 5| 5| 5| 3| 3| 3| 3| 9| 3| 3| 2| 2| 5| 0| 6| 8| 5| 5|
| 9| 4| 1| 4| 4| 9| 7| 8| 8| 8| 1| 0| 0| 0| 7| 0| 0| 9| 9| 8| 3| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Arteriole, Inflammation, | |
Proliferative | 4 |
Duct, Inflammation, Chronic | 1 1 1 1 1 |
Duct, Metaplasia, Squamous | 2 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + A + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + |
Acanthosis | 3 3 |
Hyperkeratosis | 3 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 1 1 2 3 2 2 1 1 2 2 2 1 1 1 2 |
Atrium, Inflammation, Chronic | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Accessory Adrenal Cortical Nodule | |
Angiectasis | |
Atrophy | 3 |
Cyst | 2 |
Degeneration, Fatty, Focal | 1 1 4 |
Degeneration, Focal | 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 1 2 3 |
Vacuolization Cytoplasmic | 3 2 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
Pars Distalis, Cyst | 3 2 2 2 3 2 3 |
Pars Distalis, Hyperplasia | 2 4 2 4 4 4 2 2 3 |
Rathke's Cleft, Crystals | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 3 4 4 4 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 5| 4| 4|
DAY ON TEST | 2| 1| 1| 9| 3| 2| 0| 5| 5| 5| 3| 3| 3| 3| 9| 3| 3| 2| 2| 5| 0| 6| 8| 5| 5|
| 9| 4| 1| 4| 4| 9| 7| 8| 8| 8| 1| 0| 0| 0| 7| 0| 0| 9| 9| 8| 3| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + |
Cyst | 2 2 |
Inflammation, Chronic | 1 |
Inflammation, Granulomatous | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Corpus Luteum, Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Oviduct | |
Inflammation, Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 1 |
Cervix, Abscess | 3 |
Cervix, Inflammation, Proliferative | 3 |
Cervix, Epithelium, Degeneration, | |
Mucoid | 4 |
Endometrium, Hyperplasia, Cystic | 2 4 3 4 2 1 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Erythroid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Mediastinal, Hyperplasia, Macrophage | |
Mediastinal, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Infarct | 4 |
__________________________________________________________________________|
Thymus | + + + + + M M + + + + + + + + + + + + + |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 5| 4| 4|
DAY ON TEST | 2| 1| 1| 9| 3| 2| 0| 5| 5| 5| 3| 3| 3| 3| 9| 3| 3| 2| 2| 5| 0| 6| 8| 5| 5|
| 9| 4| 1| 4| 4| 9| 7| 8| 8| 8| 1| 0| 0| 0| 7| 0| 0| 9| 9| 8| 3| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + |
Abscess | |
Cyst | 4 3 3 3 3 4 |
Hyperplasia | 3 2 3 2 2 3 3 3 3 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | |
Ulcer | |
Subcutaneous Tissue, Cyst | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Compression | 3 |
Cerebrum, Mineralization | |
Ventricle, Dilatation | 3 |
__________________________________________________________________________|
Spinal Cord | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Edema | |
Hyperplasia, Macrophage | |
Hyperplasia, Adenomatous | |
Interstitium, Inflammation, Chronic | |
Interstitium, Inflammation, | |
Granulomatous | |
Pleura, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Inflammation, Chronic | 2 |
Nasolacrimal Duct, Cyst | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 2 1 2 1 1 2 2 1 2 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 3 1 1 3 1 3 2 3 4 2 4 3 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
Glands, Cyst | 2 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | 2 |
Cornea, Proliferation | 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 5| 4| 4|
DAY ON TEST | 2| 1| 1| 9| 3| 2| 0| 5| 5| 5| 3| 3| 3| 3| 9| 3| 3| 2| 2| 5| 0| 6| 8| 5| 5|
| 9| 4| 1| 4| 4| 9| 7| 8| 8| 8| 1| 0| 0| 0| 7| 0| 0| 9| 9| 8| 3| 9| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Inflammation, Chronic | 2 1 2 1 1 1 1 2 |
Mineralization | 1 |
Necrosis, Coagulative | 2 |
Nephropathy | 3 1 1 2 2 3 2 2 2 2 3 2 1 2 4 4 4 |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia,| |
Papillary | 1 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 3| 2| 2| 2| 9| 3| 3| 3| 3| 9| | |
| 1| 0| 9| 6| 8| 0| 9| 9| 9| 0| 1| 1| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 55 |
Erosion | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 55 |
Basophilic Focus | 3 2 2 2 1 1 2 2 2 3 | 30 1.9|
Clear Cell Focus | 2 1 | 5 1.8|
Congestion | 3 | 1 3.0|
Cytomegaly | | 2 2.5|
Fatty Change | 1 2 3 | 9 2.0|
Fibrosis, Focal | 2 | 2 2.0|
Focal Cellular Change | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X | 11 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 3 1 1 | 31 1.3|
Inflammation, Granulomatous | | 1 1.0|
Mineralization | 2 | 1 2.0|
Mixed Cell Focus | | 2 1.5|
Necrosis, Coagulative | 3 | 4 2.8|
Arteriole, Inflammation, | | |
Proliferative | | 1 3.0|
Bile Duct, Hyperplasia | 1 2 1 3 3 1 1 1 1 2 3 3 2 | 41 1.9|
Centrilobular, Atrophy | 2 3 | 10 2.4|
Sinusoid, Dilatation | | 3 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + + | 16 |
Pigmentation, Hemosiderin | 3 | 1 3.0|
Fat, Hemorrhage | 2 | 2 2.5|
Fat, Inflammation, Acute | | 1 4.0|
Fat, Inflammation, Chronic | 2 3 | 5 2.0|
Fat, Necrosis | 2 | 7 1.9|
Fat, Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 3| 2| 2| 2| 9| 3| 3| 3| 3| 9| | |
| 1| 0| 9| 6| 8| 0| 9| 9| 9| 0| 1| 1| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 55 |
Focal Cellular Change | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 55 |
Atrophy, Focal | 1 1 | 3 1.3|
Cytoplasmic Alteration | | 2 1.0|
Arteriole, Inflammation, | | |
Proliferative | | 1 4.0|
Duct, Inflammation, Chronic | | 6 1.2|
Duct, Metaplasia, Squamous | 1 1 | 12 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 54 |
Acanthosis | | 2 3.0|
Hyperkeratosis | | 2 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Tooth | + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 55 |
Cardiomyopathy | 1 1 2 2 1 1 1 1 1 1 2 | 42 1.5|
Atrium, Inflammation, Chronic | | 1 2.0|
Atrium, Thrombosis | X X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 55 |
Accessory Adrenal Cortical Nodule | X | 2 |
Angiectasis | 3 | 4 2.5|
Atrophy | | 1 3.0|
Cyst | 4 1 | 3 2.3|
Degeneration, Fatty, Focal | 2 1 1 | 8 1.9|
Degeneration, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | | 2 1.5|
Hyperplasia | 1 2 1 | 12 1.8|
Vacuolization Cytoplasmic | 4 3 2 | 7 2.7|
Capsule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 54 |
Hyperplasia | 2 1 | 11 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 3| 2| 2| 2| 9| 3| 3| 3| 3| 9| | |
| 1| 0| 9| 6| 8| 0| 9| 9| 9| 0| 1| 1| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + | 54 |
Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + | 54 |
Hyperplasia | | 1 2.0|
Pars Distalis, Cyst | 2 2 2 3 3 | 20 2.6|
Pars Distalis, Hyperplasia | 2 1 1 3 3 | 26 2.9|
Rathke's Cleft, Crystals | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 55 |
C-Cell, Hyperplasia | 2 3 4 1 | 14 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + | 52 |
Cyst | 3 2 2 | 9 2.4|
Inflammation, Chronic | 1 | 5 1.6|
Inflammation, Granulomatous | | 1 2.0|
Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + | 55 |
Corpus Luteum, Cyst | 1 | 1 1.0|
Periovarian Tissue, Cyst | 4 | 2 3.5|
__________________________________________________________________________|____________|
Oviduct | | 2 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 55 |
Inflammation, Suppurative | 2 | 2 1.5|
Cervix, Abscess | 3 3 | 4 3.0|
Cervix, Inflammation, Proliferative | | 1 3.0|
Cervix, Epithelium, Degeneration, | | |
Mucoid | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3 4 | 15 2.6|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + | 18 |
Neutrophilia | X X | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 55 |
Erythroid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 3| 2| 2| 2| 9| 3| 3| 3| 3| 9| | |
| 1| 0| 9| 6| 8| 0| 9| 9| 9| 0| 1| 1| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hyperplasia, Macrophage | | 1 3.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 52 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia, Plasma Cell | 4 | 2 3.5|
Sinus, Ectasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + | 54 |
Congestion | | 1 4.0|
Hyperplasia, Plasma Cell | | 1 3.0|
Sinus, Ectasia | | 3 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 55 |
Fibrosis | 2 1 | 2 1.5|
Hematopoietic Cell Proliferation | | 2 3.0|
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + | 51 |
Cyst | 1 | 5 1.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + | 54 |
Abscess | | 1 1.0|
Cyst | 4 4 2 2 | 14 3.4|
Hyperplasia | 3 2 3 2 3 3 2 3 1 | 30 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 55 |
Cyst Epithelial Inclusion | | 1 |
Ulcer | 3 | 2 3.0|
Subcutaneous Tissue, Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 55 |
Compression | X | 2 3.0|
Cerebrum, Mineralization | | 1 1.0|
Ventricle, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 7| 5| 3| 2| 2| 2| 9| 3| 3| 3| 3| 9| | |
| 1| 0| 9| 6| 8| 0| 9| 9| 9| 0| 1| 1| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
50 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 55 |
Edema | | 1 2.0|
Hyperplasia, Macrophage | | 1 2.0|
Hyperplasia, Adenomatous | | 2 2.0|
Interstitium, Inflammation, Chronic | | 1 1.0|
Interstitium, Inflammation, | | |
Granulomatous | | 1 2.0|
Pleura, Inflammation, Chronic | 1 | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 55 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | | 4 2.5|
Nasolacrimal Duct, Cyst | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 1 3 1 2 | 28 1.7|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | 3 2 1 2 2 3 3 3 3 | 40 2.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 55 |
Glands, Cyst | 1 2 | 6 2.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 6 |
Hemorrhage | 2 2 | 3 2.0|
Cornea, Proliferation | | 1 2.0|
Retina, Atrophy | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 55 |
Cyst | | 1 2.0|
Inflammation, Chronic | 2 1 1 | 18 1.3|
Mineralization | | 4 1.3|
Necrosis, Coagulative | | 1 2.0|
Nephropathy | 1 1 3 1 3 3 3 1 2 2 2 2 2 | 46 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + M | 51 |
Inflammation, Chronic | 1 | 3 1.0|
Transitional Epithelium, Hyperplasia,| | |
Papillary | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 2| 7| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 7| 3| 3| 3| 4| 3| 3| 7| 3| 8| 3| 3| 6| 6| 5|
| 1| 1| 1| 7| 9| 2| 2| 2| 1| 9| 3| 2| 1| 1| 6| 2| 0| 6| 7| 3| 2| 1| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + M + + A + + + + + + A + + + + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | 1 1 1 2 2 1 |
Clear Cell Focus | |
Concretion | |
Cytomegaly | 2 |
Degeneration, Cystic | 2 2 2 2 2 2 1 2 3 1 |
Eosinophilic Focus | 1 2 2 |
Fatty Change | 2 2 |
Hematopoietic Cell Proliferation | 1 2 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | |
Inflammation, Chronic | 3 1 1 1 2 1 2 |
Mixed Cell Focus | 3 2 |
Necrosis, Coagulative | 2 2 3 2 |
Bile Duct, Dilatation | |
Bile Duct, Hyperplasia | 3 2 2 2 4 2 4 3 2 2 2 2 3 2 2 2 3 3 3 4 3 2 |
Centrilobular, Atrophy | 3 3 3 |
Serosa, Fibrosis, Focal | 2 |
Sinusoid, Dilatation | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic | 2 |
Fat, Inflammation, Granulomatous | |
Fat, Mineralization | |
Fat, Necrosis | 2 |
Lymphatic, Ectasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + |
Atrophy | 1 |
Hyperplasia, Nodular | |
Inflammation, Chronic | 1 |
Acinus, Hyperplasia | |
Arteriole, Inflammation, Chronic | 3 |
Duct, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Pharynx | |
Abscess | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 2| 7| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 7| 3| 3| 3| 4| 3| 3| 7| 3| 8| 3| 3| 6| 6| 5|
| 1| 1| 1| 7| 9| 2| 2| 2| 1| 9| 3| 2| 1| 1| 6| 2| 0| 6| 7| 3| 2| 1| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cytoplasmic Alteration | |
Duct, Hyperplasia | 1 |
Duct, Inflammation, Chronic | 3 1 1 1 1 |
Duct, Metaplasia, Squamous | 2 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Edema | |
Hyperkeratosis | 2 |
Hyperplasia, Papillary | 3 |
Inflammation, Chronic | 1 |
Ulcer | 3 |
Epithelium, Degeneration, Ballooning | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 3 2 2 2 2 2 2 2 2 3 3 1 2 2 3 |
Mineralization | |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Cyst | |
Degeneration, Fatty, Focal | 2 1 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 1 3 2 3 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 2 1 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + |
Pars Distalis, Cyst | 1 4 1 |
Pars Distalis, Fibrosis | |
Pars Distalis, Hyperplasia | 1 3 2 2 |
Pars Distalis, Necrosis | |
Pars Intermedia, Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 2| 7| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 7| 3| 3| 3| 4| 3| 3| 7| 3| 8| 3| 3| 6| 6| 5|
| 1| 1| 1| 7| 9| 2| 2| 2| 1| 9| 3| 2| 1| 1| 6| 2| 0| 6| 7| 3| 2| 1| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Ultimobranchial Cyst | 2 1 |
C-Cell, Hyperplasia | 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + M + |
Degeneration, Mucoid | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + M + + + + + + + + + + + + + |
Abscess | 3 |
Cyst | 2 2 |
Hyperplasia | 3 |
Inflammation, Chronic | 1 1 1 1 |
Inflammation, Suppurative | 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 1 |
Inflammation, Chronic | 1 1 1 2 |
Inflammation, Suppurative | 1 3 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + M + |
Atrophy | 4 1 4 4 3 2 4 4 2 4 2 3 3 2 4 2 2 |
Interstitial Cell, Hyperplasia | 3 2 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + |
Left Shift | |
Neutrophilia | |
Thrombocytopenia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Bronchial, Sinus, Ectasia | |
Inguinal, Hyperplasia, Plasma Cell | 4 |
Inguinal, Sinus, Ectasia | |
Mediastinal, Hyperplasia, Macrophage | 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mediastinal, Sinus, Ectasia | 2 |
Pancreatic, Hyperplasia, Macrophage | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 2| 7| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 7| 3| 3| 3| 4| 3| 3| 7| 3| 8| 3| 3| 6| 6| 5|
| 1| 1| 1| 7| 9| 2| 2| 2| 1| 9| 3| 2| 1| 1| 6| 2| 0| 6| 7| 3| 2| 1| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Sinus, Ectasia | |
Renal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + |
Congestion | 3 |
Hyperplasia, Plasma Cell | 2 |
Sinus, Ectasia | 2 2 2 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + |
Congestion | |
Hyperplasia, Macrophage | 3 |
Hyperplasia, Plasma Cell | 3 3 |
Pigmentation, Hemosiderin | |
Sinus, Ectasia | 2 2 3 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 3 3 |
Hemorrhage | 4 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Thymus | M + + + + + M + + + + + + + M + + + + M + + |
Cyst | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + M + + + + + + + + + + + + + |
Hyperplasia | 1 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 |
Inflammation, Proliferative | |
Ulcer | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Compression | X X |
__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 2| 7| 7| 7| 6| 7| 7| 6| 6| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 6| 5| 3| 3| 3| 3| 5| 7| 3| 3| 3| 4| 3| 3| 7| 3| 8| 3| 3| 6| 6| 5|
| 1| 1| 1| 7| 9| 2| 2| 2| 1| 9| 3| 2| 1| 1| 6| 2| 0| 6| 7| 3| 2| 1| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 4 |
Hyperplasia, Macrophage | 3 2 3 3 |
Hyperplasia, Adenomatous | |
Inflammation, Acute | |
Inflammation, Granulomatous | |
Necrosis, Coagulative | |
Bronchiole, Foreign Body | |
Interstitium, Inflammation, Chronic | 1 4 |
Pleura, Inflammation, Chronic | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 1 2 2 2 1 2 2 2 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 3 1 3 2 2 2 2 2 1 2 2 1 2 2 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
Exudate | |
Inflammation, Chronic | 1 1 |
Glands, Cyst | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Middle Ear, Inflammation, Suppurative| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Infarct | 2 |
Inflammation, Chronic | 1 2 2 2 2 2 2 2 2 2 2 2 |
Mineralization | 1 |
Necrosis, Coagulative | |
Nephropathy | 3 4 4 3 4 3 3 3 1 3 2 3 2 4 4 2 2 2 3 3 2 2 |
Renal Tubule, Inflammation, | |
Suppurative | 1 1 |
Transitional Epithelium, Hyperplasia,| |
Papillary | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 3| 7| 6| 6| 4| 4|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 9| 5| 5| 3| 3| 2| 1| 0| 3| 3| 1| 9| 8| 3| 8| 1| 5| 5|
| 7| 2| 1| 1| 2| 1| 1| 6| 9| 9| 1| 1| 9| 5| 2| 2| 2| 3| 3| 1| 1| 3| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + M + + + A + + + + A + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | 1 1 2 |
Clear Cell Focus | 1 |
Concretion | 3 |
Cytomegaly | 1 |
Degeneration, Cystic | 1 2 2 1 3 2 2 3 3 |
Eosinophilic Focus | 3 |
Fatty Change | 2 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 3 |
Inflammation, Chronic | 3 2 1 1 1 1 1 1 1 |
Mixed Cell Focus | 2 3 |
Necrosis, Coagulative | 3 4 |
Bile Duct, Dilatation | 2 |
Bile Duct, Hyperplasia | 3 2 3 4 2 3 4 2 2 3 2 3 3 2 2 3 1 4 4 2 |
Centrilobular, Atrophy | |
Serosa, Fibrosis, Focal | |
Sinusoid, Dilatation | 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic | 2 |
Fat, Inflammation, Granulomatous | |
Fat, Mineralization | 2 |
Fat, Necrosis | 2 |
Lymphatic, Ectasia | |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + |
Atrophy | 1 2 1 2 |
Hyperplasia, Nodular | |
Inflammation, Chronic | |
Acinus, Hyperplasia | 2 |
Arteriole, Inflammation, Chronic | |
Duct, Inflammation, Chronic | |
__________________________________________________________________________|
Pharynx | |
Abscess | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 3| 7| 6| 6| 4| 4|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 9| 5| 5| 3| 3| 2| 1| 0| 3| 3| 1| 9| 8| 3| 8| 1| 5| 5|
| 7| 2| 1| 1| 2| 1| 1| 6| 9| 9| 1| 1| 9| 5| 2| 2| 2| 3| 3| 1| 1| 3| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cytoplasmic Alteration | 1 |
Duct, Hyperplasia | |
Duct, Inflammation, Chronic | 1 1 1 1 |
Duct, Metaplasia, Squamous | 2 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 3 1 |
Edema | |
Hyperkeratosis | |
Hyperplasia, Papillary | 2 3 |
Inflammation, Chronic | 2 2 1 |
Ulcer | |
Epithelium, Degeneration, Ballooning | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Tongue | + + |
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 3 3 3 2 2 1 3 2 2 3 2 2 2 2 2 2 |
Mineralization | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Cyst | 2 |
Degeneration, Fatty, Focal | 2 2 2 |
Hyperplasia | 2 2 2 2 2 2 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 2 2 3 2 3 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 3 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | 1 3 2 |
Pars Distalis, Fibrosis | |
Pars Distalis, Hyperplasia | 3 1 2 3 2 |
Pars Distalis, Necrosis | |
Pars Intermedia, Cyst | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 3| 7| 6| 6| 4| 4|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 9| 5| 5| 3| 3| 2| 1| 0| 3| 3| 1| 9| 8| 3| 8| 1| 5| 5|
| 7| 2| 1| 1| 2| 1| 1| 6| 9| 9| 1| 1| 9| 5| 2| 2| 2| 3| 3| 1| 1| 3| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 3 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Mucoid | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | M + + + + + + + + + + + + + + + + + + + + |
Abscess | |
Cyst | 2 3 2 |
Hyperplasia | 2 |
Inflammation, Chronic | 1 1 1 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Prostate | + M + + + + + + M + + + + + + + + + + + + |
Hyperplasia | |
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + M + + + + + + M + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 3 2 2 4 4 4 3 1 4 4 3 4 2 3 |
Interstitial Cell, Hyperplasia | 4 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + |
Left Shift | X |
Neutrophilia | X X |
Thrombocytopenia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Bronchial, Sinus, Ectasia | 2 |
Inguinal, Hyperplasia, Plasma Cell | |
Inguinal, Sinus, Ectasia | 2 |
Mediastinal, Hyperplasia, Macrophage | 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | 3 |
Mediastinal, Sinus, Ectasia | |
Pancreatic, Hyperplasia, Macrophage | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 3| 7| 6| 6| 4| 4|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 9| 5| 5| 3| 3| 2| 1| 0| 3| 3| 1| 9| 8| 3| 8| 1| 5| 5|
| 7| 2| 1| 1| 2| 1| 1| 6| 9| 9| 1| 1| 9| 5| 2| 2| 2| 3| 3| 1| 1| 3| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Sinus, Ectasia | 3 |
Renal, Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hyperplasia, Macrophage | 3 |
Hyperplasia, Plasma Cell | |
Pigmentation, Hemosiderin | 1 |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia, Macrophage | 3 |
__________________________________________________________________________|
Thymus | M + M M + + M + + + + + + + + + + + + + + |
Cyst | 2 |
Epithelial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M + + + M + + + + + + + + + + + M + |
Hyperplasia | 1 1 3 2 1 2 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 3 |
Inflammation, Proliferative | 3 |
Ulcer | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Compression | X |
__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 6| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 3| 7| 6| 6| 4| 4|
DAY ON TEST | 6| 3| 3| 3| 0| 3| 3| 9| 5| 5| 3| 3| 2| 1| 0| 3| 3| 1| 9| 8| 3| 8| 1| 5| 5|
| 7| 2| 1| 1| 2| 1| 1| 6| 9| 9| 1| 1| 9| 5| 2| 2| 2| 3| 3| 1| 1| 3| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hyperplasia, Macrophage | 3 4 2 |
Hyperplasia, Adenomatous | 2 4 2 |
Inflammation, Acute | 3 |
Inflammation, Granulomatous | |
Necrosis, Coagulative | 3 |
Bronchiole, Foreign Body | 2 |
Interstitium, Inflammation, Chronic | 2 2 |
Pleura, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 1 |
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 1 1 2 1 1 2 2 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 2 3 1 3 2 2 2 3 2 3 1 2 2 1 2 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
Exudate | X |
Inflammation, Chronic | |
Glands, Cyst | 3 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Middle Ear, Inflammation, Suppurative| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Infarct | |
Inflammation, Chronic | 2 2 2 2 2 2 2 3 2 2 2 2 |
Mineralization | |
Necrosis, Coagulative | 4 |
Nephropathy | 3 3 4 3 3 4 2 4 3 3 3 3 4 2 3 3 3 3 2 |
Renal Tubule, Inflammation, | |
Suppurative | 2 |
Transitional Epithelium, Hyperplasia,| |
Papillary | |
__________________________________________________________________________|
Urinary Bladder | + M + + A + + + M + + + + + + + + + + + + |
Inflammation, Chronic | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4| | |
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 1| 0| 5| 3| 4| 1| 5| 5| | |
| 2| 2| 1| 4| 9| 1| 0| 0| 2| 9| 2| 6| 5| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A A + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + M A + + + + + | 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 55 |
Basophilic Focus | 2 2 | 11 1.5|
Clear Cell Focus | | 1 1.0|
Concretion | | 1 3.0|
Cytomegaly | | 2 1.5|
Degeneration, Cystic | 2 1 2 2 2 2 2 | 26 2.0|
Eosinophilic Focus | | 4 2.0|
Fatty Change | 1 | 5 1.8|
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | X | 6 |
Hyperplasia, Focal | | 1 3.0|
Inflammation, Chronic | 1 1 | 18 1.4|
Mixed Cell Focus | 2 3 | 6 2.5|
Necrosis, Coagulative | 2 | 7 2.6|
Bile Duct, Dilatation | | 1 2.0|
Bile Duct, Hyperplasia | 2 3 2 3 3 3 2 3 3 2 2 2 | 54 2.6|
Centrilobular, Atrophy | 3 3 | 5 3.0|
Serosa, Fibrosis, Focal | | 1 2.0|
Sinusoid, Dilatation | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 12 |
Fat, Inflammation, Chronic | 2 2 | 4 2.0|
Fat, Inflammation, Granulomatous | 3 | 1 3.0|
Fat, Mineralization | | 1 2.0|
Fat, Necrosis | 2 | 3 2.0|
Lymphatic, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 53 |
Atrophy | 2 | 6 1.5|
Hyperplasia, Nodular | 3 | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4| | |
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 1| 0| 5| 3| 4| 1| 5| 5| | |
| 2| 2| 1| 4| 9| 1| 0| 0| 2| 9| 2| 6| 5| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Arteriole, Inflammation, Chronic | | 1 3.0|
Duct, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Abscess | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 54 |
Cytoplasmic Alteration | 2 | 2 1.5|
Duct, Hyperplasia | | 1 1.0|
Duct, Inflammation, Chronic | 1 2 1 2 1 2 | 15 1.3|
Duct, Metaplasia, Squamous | 1 2 2 2 2 | 12 1.7|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 55 |
Acanthosis | 2 | 3 2.0|
Edema | 2 | 1 2.0|
Hyperkeratosis | 2 | 2 2.0|
Hyperplasia, Papillary | | 3 2.7|
Inflammation, Chronic | | 4 1.5|
Ulcer | | 1 3.0|
Epithelium, Degeneration, Ballooning | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Tongue | | 2 |
__________________________________________________________________________|____________|
Tooth | + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 55 |
Cardiomyopathy | 2 1 2 1 1 1 1 3 1 1 2 | 46 2.0|
Mineralization | 2 | 1 2.0|
Atrium, Thrombosis | X | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 54 |
Angiectasis | | 1 2.0|
Cyst | | 1 2.0|
Degeneration, Fatty, Focal | 3 | 6 2.0|
Hyperplasia | | 7 1.9|
Vacuolization Cytoplasmic | 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 55 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 3 2 2 | 19 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4| | |
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 1| 0| 5| 3| 4| 1| 5| 5| | |
| 2| 2| 1| 4| 9| 1| 0| 0| 2| 9| 2| 6| 5| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + | 54 |
Hyperplasia | | 3 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + | 54 |
Hyperplasia | 2 2 3 | 13 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 54 |
Pars Distalis, Cyst | 2 | 7 2.0|
Pars Distalis, Fibrosis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 1 | 12 2.0|
Pars Distalis, Necrosis | 3 | 1 3.0|
Pars Intermedia, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 55 |
Ultimobranchial Cyst | | 2 1.5|
C-Cell, Hyperplasia | 4 2 | 4 2.8|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + M + + + + + + + + + | 53 |
Degeneration, Mucoid | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + | 53 |
Abscess | | 1 3.0|
Cyst | | 5 2.2|
Hyperplasia | | 2 2.5|
Inflammation, Chronic | 1 2 1 2 | 12 1.3|
Inflammation, Suppurative | 2 | 5 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + | 53 |
Hyperplasia | 2 | 3 1.3|
Inflammation, Chronic | 2 | 7 1.6|
Inflammation, Suppurative | 2 3 | 9 2.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + | 53 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + | 54 |
Atrophy | 4 3 4 4 4 2 3 4 | 39 3.1|
Interstitial Cell, Hyperplasia | 3 4 1 1 | 11 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4| | |
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 1| 0| 5| 3| 4| 1| 5| 5| | |
| 2| 2| 1| 4| 9| 1| 0| 0| 2| 9| 2| 6| 5| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + | 22 |
Left Shift | | 1 |
Neutrophilia | | 2 |
Thrombocytopenia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 55 |
Myeloid Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 55 |
Bronchial, Sinus, Ectasia | | 1 2.0|
Inguinal, Hyperplasia, Plasma Cell | | 1 4.0|
Inguinal, Sinus, Ectasia | | 1 2.0|
Mediastinal, Hyperplasia, Macrophage | | 2 2.5|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 3.0|
Mediastinal, Sinus, Ectasia | | 1 2.0|
Pancreatic, Hyperplasia, Macrophage | 2 | 1 2.0|
Pancreatic, Sinus, Ectasia | 2 | 2 2.5|
Renal, Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + | 52 |
Congestion | | 1 3.0|
Hyperplasia, Plasma Cell | 3 | 2 2.5|
Sinus, Ectasia | 4 | 7 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + | 53 |
Congestion | 3 | 1 3.0|
Hyperplasia, Macrophage | | 2 3.0|
Hyperplasia, Plasma Cell | 3 | 3 3.0|
Pigmentation, Hemosiderin | | 1 1.0|
Sinus, Ectasia | 3 3 2 3 2 | 9 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 55 |
Fibrosis | 2 2 4 | 7 2.3|
Hematopoietic Cell Proliferation | 3 | 3 3.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Macrophage | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + | 46 |
Cyst | | 1 2.0|
Epithelial Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 49 |
Hyperplasia | 3 2 1 2 | 14 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4| | |
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 1| 0| 5| 3| 4| 1| 5| 5| | |
| 2| 2| 1| 4| 9| 1| 0| 0| 2| 9| 2| 6| 5| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 55 |
Inflammation, Chronic | 2 3 | 4 2.5|
Inflammation, Proliferative | | 1 3.0|
Ulcer | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 4 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 55 |
Compression | X | 4 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + M | 13 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 55 |
Congestion | 3 | 2 3.5|
Hyperplasia, Macrophage | | 7 2.9|
Hyperplasia, Adenomatous | | 3 2.7|
Inflammation, Acute | | 1 3.0|
Inflammation, Granulomatous | 1 | 1 1.0|
Necrosis, Coagulative | | 1 3.0|
Bronchiole, Foreign Body | | 1 2.0|
Interstitium, Inflammation, Chronic | | 4 2.3|
Pleura, Inflammation, Chronic | 2 | 4 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 55 |
Inflammation, Chronic | 2 1 1 4 | 8 1.9|
Inflammation, Suppurative | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 2 2 2 1 2 1 | 27 1.6|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 3 2.3|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | 3 2 2 2 2 2 1 2 1 1 | 45 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4| | |
DAY ON TEST | 3| 3| 8| 5| 5| 3| 3| 1| 0| 5| 3| 4| 1| 5| 5| | |
| 2| 2| 1| 4| 9| 1| 0| 0| 2| 9| 2| 6| 5| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 53 |
Exudate | | 1 |
Inflammation, Chronic | 1 | 3 1.0|
Glands, Cyst | | 4 1.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
Middle Ear, Inflammation, Suppurative| 3 | 1 3.0|
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 55 |
Infarct | | 1 2.0|
Inflammation, Chronic | 2 2 2 | 27 2.0|
Mineralization | | 1 1.0|
Necrosis, Coagulative | | 1 4.0|
Nephropathy | 4 4 3 3 4 2 2 2 3 3 3 1 | 53 2.9|
Renal Tubule, Inflammation, | | |
Suppurative | 1 | 4 1.3|
Transitional Epithelium, Hyperplasia,| | |
Papillary | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + | 51 |
Inflammation, Chronic | | 7 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 6| 4| 2| 7| 6| 5| 5| 4| 0| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 1| 5| 8| 4| 5| 2| 1| 1| 5| 6| 3| 3| 9| 3| 5| 8| 3| 3| 8| 3| 3| 3| 3| 5| 5|
| 8| 1| 3| 0| 9| 5| 7| 0| 9| 3| 2| 2| 9| 6| 9| 6| 2| 1| 9| 1| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + |
Ulcer | 3 |
Venule, Thrombosis | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + M + + + M + + |
Edema | |
Hemorrhage | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | 2 1 1 1 |
Clear Cell Focus | 3 2 |
Cytomegaly | |
Degeneration, Cystic | 1 1 1 2 1 2 2 2 2 |
Eosinophilic Focus | |
Fatty Change | 3 1 |
Focal Cellular Change | 2 |
Hematocyst | |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Multifocal | |
Inflammation, Chronic | 1 2 1 2 1 1 1 |
Mixed Cell Focus | 2 |
Necrosis, Coagulative | 2 2 |
Bile Duct, Hyperplasia | 3 3 2 3 3 4 2 4 3 3 1 1 3 3 3 2 4 2 |
Centrilobular, Atrophy | 2 3 |
Serosa, Inflammation, Chronic | |
Sinusoid, Dilatation | 2 2 1 |
Vein, Dilatation | |
__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | X X |
Fat, Inflammation, Chronic | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + |
Atrophy | 2 1 2 |
Hyperplasia, Nodular | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + |
Cytoplasmic Alteration | 1 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 6| 4| 2| 7| 6| 5| 5| 4| 0| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 1| 5| 8| 4| 5| 2| 1| 1| 5| 6| 3| 3| 9| 3| 5| 8| 3| 3| 8| 3| 3| 3| 3| 5| 5|
| 8| 1| 3| 0| 9| 5| 7| 0| 9| 3| 2| 2| 9| 6| 9| 6| 2| 1| 9| 1| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Duct, Inflammation, Chronic | 1 |
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + |
Abscess | 1 |
Hemorrhage | |
Hyperplasia, Papillary | |
Inflammation, Chronic | 1 |
Ulcer, Chronic | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + |
Erosion | |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Ulcer | 2 |
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + |
Cardiomyopathy | 2 3 2 2 2 2 2 2 2 1 2 3 |
Thrombosis | |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + |
Degeneration, Fatty, Focal | 1 1 |
Hyperplasia | 1 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 2 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Atrophy | |
Fibrosis | |
Hyperplasia | 3 2 1 2 2 2 |
Mineralization | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | 2 3 1 |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 3 2 3 1 2 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 6| 4| 2| 7| 6| 5| 5| 4| 0| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 1| 5| 8| 4| 5| 2| 1| 1| 5| 6| 3| 3| 9| 3| 5| 8| 3| 3| 8| 3| 3| 3| 3| 5| 5|
| 8| 1| 3| 0| 9| 5| 7| 0| 9| 3| 2| 2| 9| 6| 9| 6| 2| 1| 9| 1| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Necrosis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 2 1 |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + M + + + + M + + |
Abscess | 2 |
Cyst | 4 4 |
Hyperplasia | |
Inflammation, Chronic | 1 1 2 1 2 1 2 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + |
Abscess | |
Hemorrhage | 2 |
Hyperplasia, Focal | 2 |
Hyperplasia | |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 1 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + |
Atrophy | 3 2 3 2 3 4 2 4 3 4 |
Cyst | |
Bilateral, Interstitial Cell, | |
Hyperplasia | 2 |
Interstitial Cell, Hyperplasia | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + |
Anemia | X |
Hypersegmentation | X |
Neutrophilia | X X |
Thrombocytopenia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + |
Depletion Cellular | |
Myelofibrosis | |
Myeloid Cell, Hyperplasia | 3 3 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 6| 4| 2| 7| 6| 5| 5| 4| 0| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 1| 5| 8| 4| 5| 2| 1| 1| 5| 6| 3| 3| 9| 3| 5| 8| 3| 3| 8| 3| 3| 3| 3| 5| 5|
| 8| 1| 3| 0| 9| 5| 7| 0| 9| 3| 2| 2| 9| 6| 9| 6| 2| 1| 9| 1| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Bronchial, Pigmentation, Hemosiderin | |
Bronchial, Sinus, Ectasia | |
Iliac, Sinus, Ectasia | 4 |
Inguinal, Hyperplasia, Plasma Cell | 2 |
Lumbar, Hyperplasia, Macrophage | |
Lumbar, Hyperplasia, Plasma Cell | |
Lumbar, Pigmentation, Hemosiderin | 3 |
Lumbar, Sinus, Ectasia | 2 2 |
Mediastinal, Hyperplasia, Macrophage | |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Sinus, Ectasia | 1 3 |
Pancreatic, Sinus, Ectasia | 2 |
Renal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 4 |
Sinus, Ectasia | 4 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + |
Depletion Lymphoid | |
Hyperplasia, Macrophage | 3 |
Sinus, Ectasia | 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Fibrosis | 4 |
Hematopoietic Cell Proliferation | 3 4 3 |
Capsule, Infarct | 2 |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | M + + + + + + + M + + + + + M |
Cyst | |
Inflammation | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + M + M |
Hyperplasia | 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | |
Inflammation, Chronic | 3 |
Inflammation, Granulomatous | |
Ulcer | 2 |
Hindlimb, Subcutaneous Tissue, Right,| |
Inflammation, Acute | 4 |
Hindlimb, Right, Epidermis, Abscess, | |
Multiple | 3 |
Hindlimb, Right, Epidermis, | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 6| 4| 2| 7| 6| 5| 5| 4| 0| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 1| 5| 8| 4| 5| 2| 1| 1| 5| 6| 3| 3| 9| 3| 5| 8| 3| 3| 8| 3| 3| 3| 3| 5| 5|
| 8| 1| 3| 0| 9| 5| 7| 0| 9| 3| 2| 2| 9| 6| 9| 6| 2| 1| 9| 1| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Degeneration, Ballooning | 4 |
Sebaceous Gland, Hyperplasia | 3 |
Subcutaneous Tissue, Cyst | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + |
Compression | |
Cerebellum, Embolus Tumor | |
Cerebellum, Infarct | |
Choroid Plexus, Inflammation, Chronic| |
Ventricle, Dilatation | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + |
Congestion | |
Hemorrhage | 2 |
Hyperplasia, Macrophage | 3 |
Hyperplasia, Adenomatous | |
Arteriole, Media, Hyperplasia | |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 |
Metaplasia, Squamous | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 2 2 1 3 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 2 1 2 3 2 1 3 2 |
Respiratory Epithelium, Cyst | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 6| 4| 2| 7| 6| 5| 5| 4| 0| 7| 7| 6| 4| 7| 7| 7| 4| 4|
DAY ON TEST | 1| 5| 8| 4| 5| 2| 1| 1| 5| 6| 3| 3| 9| 3| 5| 8| 3| 3| 8| 3| 3| 3| 3| 5| 5|
| 8| 1| 3| 0| 9| 5| 7| 0| 9| 3| 2| 2| 9| 6| 9| 6| 2| 1| 9| 1| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Exudate | |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | 3 |
Synechia | 3 |
Cornea, Proliferation | 2 |
Retina, Atrophy | 2 4 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Cyst | 2 |
Infarct | 3 |
Inflammation, Chronic | 2 2 3 2 2 2 3 2 2 2 2 |
Nephropathy | 4 3 3 3 2 4 3 3 3 3 2 4 3 3 2 3 3 3 |
Pelvis, Hematopoietic Cell | |
Proliferation | 2 |
Renal Tubule, Inflammation, | |
Suppurative | 2 1 |
Transitional Epithelium, Hyperplasia,| |
Papillary | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + |
Hyperplasia, Papillary | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 6| 6| 4| 7| 7| 6| 4| 4| 7| 6| 6| 6| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 2| 0| 7| 9| 6| 3| 3| 6| 5| 5| 3| 3| 3| 5| 5| 2| 6| 5| 5| 5| 9| 3| 1| 0| 5|
| 3| 9| 6| 0| 6| 1| 1| 2| 5| 9| 2| 1| 8| 9| 9| 8| 8| 6| 3| 9| 2| 1| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + + + + + + + + + A +|
Ulcer | |
Venule, Thrombosis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + +|
Serosa, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + +|
Edema | |
Hemorrhage | |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A A + + + + A + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 1 1 1 |
Clear Cell Focus | X 1 3 |
Cytomegaly | |
Degeneration, Cystic | 2 1 1 1 1 1 2 1 1 |
Eosinophilic Focus | 2 |
Fatty Change | |
Focal Cellular Change | |
Hematocyst | X |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X X|
Hyperplasia, Multifocal | |
Inflammation, Chronic | 2 1 1 1 1 1 2 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | 2 |
Bile Duct, Hyperplasia | 3 4 4 2 3 1 3 3 2 2 2 3 2 2 3 3 2 3 3 3 3|
Centrilobular, Atrophy | 3 1 2 2|
Serosa, Inflammation, Chronic | 1 |
Sinusoid, Dilatation | 2 1 |
Vein, Dilatation | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + +|
Accessory Spleen | X |
Fat, Inflammation, Chronic | 4 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + +|
Atrophy | 2 3 |
Hyperplasia, Nodular | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 6| 6| 4| 7| 7| 6| 4| 4| 7| 6| 6| 6| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 2| 0| 7| 9| 6| 3| 3| 6| 5| 5| 3| 3| 3| 5| 5| 2| 6| 5| 5| 5| 9| 3| 1| 0| 5|
| 3| 9| 6| 0| 6| 1| 1| 2| 5| 9| 2| 1| 8| 9| 9| 8| 8| 6| 3| 9| 2| 1| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Duct, Inflammation, Chronic | 2 1 |
Duct, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + +|
Abscess | |
Hemorrhage | 2 |
Hyperplasia, Papillary | 2|
Inflammation, Chronic | |
Ulcer, Chronic | |
Ulcer | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + +|
Erosion | |
Inflammation, Acute | |
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Tooth | + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 2 1 2 2 2 2 1|
Thrombosis | X |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 2 |
Hyperplasia | 1 1 |
Necrosis, Coagulative | 2|
Vacuolization Cytoplasmic | 1 1 2 2 |
Capsule, Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | |
Hyperplasia | 2 1 2 3 1 2 1 2 |
Mineralization | |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + +|
Hyperplasia | 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 2 1 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 1 2 2|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 6| 6| 4| 7| 7| 6| 4| 4| 7| 6| 6| 6| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 2| 0| 7| 9| 6| 3| 3| 6| 5| 5| 3| 3| 3| 5| 5| 2| 6| 5| 5| 5| 9| 3| 1| 0| 5|
| 3| 9| 6| 0| 6| 1| 1| 2| 5| 9| 2| 1| 8| 9| 9| 8| 8| 6| 3| 9| 2| 1| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Necrosis | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + M + M + + +|
Abscess | |
Cyst | |
Hyperplasia | 2 |
Inflammation, Chronic | 1 1 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Hemorrhage | |
Hyperplasia, Focal | |
Hyperplasia | 2 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 4 4 3 4 3 4 4 4 4 2|
Cyst | |
Bilateral, Interstitial Cell, | |
Hyperplasia | |
Interstitial Cell, Hyperplasia | 3 1 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + +|
Anemia | X |
Hypersegmentation | |
Neutrophilia | X |
Thrombocytopenia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Myelofibrosis | 3 |
Myeloid Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 6| 6| 4| 7| 7| 6| 4| 4| 7| 6| 6| 6| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 2| 0| 7| 9| 6| 3| 3| 6| 5| 5| 3| 3| 3| 5| 5| 2| 6| 5| 5| 5| 9| 3| 1| 0| 5|
| 3| 9| 6| 0| 6| 1| 1| 2| 5| 9| 2| 1| 8| 9| 9| 8| 8| 6| 3| 9| 2| 1| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Bronchial, Pigmentation, Hemosiderin | 3 |
Bronchial, Sinus, Ectasia | 3 |
Iliac, Sinus, Ectasia | |
Inguinal, Hyperplasia, Plasma Cell | |
Lumbar, Hyperplasia, Macrophage | 2 |
Lumbar, Hyperplasia, Plasma Cell | 4 |
Lumbar, Pigmentation, Hemosiderin | |
Lumbar, Sinus, Ectasia | |
Mediastinal, Hyperplasia, Macrophage | 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Mediastinal, Sinus, Ectasia | |
Pancreatic, Sinus, Ectasia | |
Renal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 4 3 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hyperplasia, Macrophage | 3 3 |
Sinus, Ectasia | 2 4 |
__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + + + +|
Fibrosis | 2 2|
Hematopoietic Cell Proliferation | 2 3 |
Capsule, Infarct | |
Capsule, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + M + + + + +|
Cyst | |
Inflammation | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 |
__________________________________________________________________________|
Skin | + + + M + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 1 |
Inflammation, Chronic | 2 |
Inflammation, Granulomatous | 3 |
Ulcer | 3 3 3 3 4|
Hindlimb, Subcutaneous Tissue, Right,| |
Inflammation, Acute | |
Hindlimb, Right, Epidermis, Abscess, | |
Multiple | |
Hindlimb, Right, Epidermis, | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 6| 6| 4| 7| 7| 6| 4| 4| 7| 6| 6| 6| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 2| 0| 7| 9| 6| 3| 3| 6| 5| 5| 3| 3| 3| 5| 5| 2| 6| 5| 5| 5| 9| 3| 1| 0| 5|
| 3| 9| 6| 0| 6| 1| 1| 2| 5| 9| 2| 1| 8| 9| 9| 8| 8| 6| 3| 9| 2| 1| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Degeneration, Ballooning | |
Sebaceous Gland, Hyperplasia | |
Subcutaneous Tissue, Cyst | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Compression | X X |
Cerebellum, Embolus Tumor | |
Cerebellum, Infarct | |
Choroid Plexus, Inflammation, Chronic| 1 |
Ventricle, Dilatation | 3 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hemorrhage | |
Hyperplasia, Macrophage | |
Hyperplasia, Adenomatous | 2 |
Arteriole, Media, Hyperplasia | 2 |
Interstitium, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 3 2 2 |
Metaplasia, Squamous | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 2 2 2 2 2 3 1 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 1 2 2 2 2 2 3 1 2 2 1|
Respiratory Epithelium, Cyst | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 6| 6| 4| 7| 7| 6| 4| 4| 7| 6| 6| 6| 4| 3| 7| 7| 7| 6|
DAY ON TEST | 2| 0| 7| 9| 6| 3| 3| 6| 5| 5| 3| 3| 3| 5| 5| 2| 6| 5| 5| 5| 9| 3| 1| 0| 5|
| 3| 9| 6| 0| 6| 1| 1| 2| 5| 9| 2| 1| 8| 9| 9| 8| 8| 6| 3| 9| 2| 1| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
25 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Exudate | X |
__________________________________________________________________________|
Eye | + |
Hemorrhage | |
Synechia | 3 |
Cornea, Proliferation | |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Infarct | |
Inflammation, Chronic | 1 1 2 2 2 2 2 2 2 2 2 |
Nephropathy | 4 4 4 1 3 2 3 2 3 3 3 2 3 2 3 2 2 3 2 3 3|
Pelvis, Hematopoietic Cell | |
Proliferation | |
Renal Tubule, Inflammation, | |
Suppurative | 1 1 1 |
Transitional Epithelium, Hyperplasia,| |
Papillary | 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
Hyperplasia, Papillary | 4 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 37 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 37 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 34 |
Ulcer | | 1 3.0|
Venule, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 35 |
Serosa, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 32 |
Edema | 3 | 1 3.0|
Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 36 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 33 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | M M + + + + + | 30 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 55 |
Basophilic Focus | 3 4 | 11 1.6|
Clear Cell Focus | 4 2 | 7 2.5|
Cytomegaly | 3 | 1 3.0|
Degeneration, Cystic | 2 3 2 2 2 | 23 1.6|
Eosinophilic Focus | 2 | 2 2.0|
Fatty Change | 2 3 | 4 2.3|
Focal Cellular Change | | 1 2.0|
Hematocyst | | 1 |
Hematopoietic Cell Proliferation | 2 | 3 1.3|
Hepatodiaphragmatic Nodule | X X X X X | 10 |
Hyperplasia, Multifocal | 3 | 1 3.0|
Inflammation, Chronic | 2 2 1 2 | 19 1.4|
Mixed Cell Focus | 2 | 2 2.0|
Necrosis, Coagulative | 4 | 4 2.5|
Bile Duct, Hyperplasia | 3 2 3 4 2 3 2 2 3 2 2 4 3 | 52 2.7|
Centrilobular, Atrophy | 4 3 | 8 2.5|
Serosa, Inflammation, Chronic | | 1 1.0|
Sinusoid, Dilatation | 1 1 | 7 1.4|
Vein, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 16 |
Accessory Spleen | | 3 |
Fat, Inflammation, Chronic | 2 | 3 2.7|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 36 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy | 2 | 6 2.0|
Hyperplasia, Nodular | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 37 |
Cytoplasmic Alteration | | 1 1.0|
Hyperplasia | | 1 2.0|
Duct, Inflammation, Chronic | | 3 1.3|
Duct, Metaplasia, Squamous | | 2 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 36 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 36 |
Abscess | | 1 1.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Papillary | 2 | 2 2.0|
Inflammation, Chronic | | 1 1.0|
Ulcer, Chronic | 4 | 1 4.0|
Ulcer | | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 34 |
Erosion | 1 | 1 1.0|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 38 |
Cardiomyopathy | 3 1 2 2 2 2 | 28 2.0|
Thrombosis | | 1 |
Atrium, Thrombosis | X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 37 |
Degeneration, Fatty, Focal | 1 | 4 1.3|
Hyperplasia | 1 | 4 1.0|
Necrosis, Coagulative | | 1 2.0|
Vacuolization Cytoplasmic | 1 2 | 7 1.6|
Capsule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 48 |
Atrophy | 4 | 1 4.0|
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 2 3 2 1 | 19 1.8|
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 36 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 36 |
Hyperplasia | 4 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + | 54 |
Pars Distalis, Cyst | 1 | 8 1.6|
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia | 2 | 14 2.1|
Pars Distalis, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 38 |
C-Cell, Hyperplasia | | 5 2.0|
Follicle, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 37 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | M + + + + + + + | 34 |
Abscess | | 1 2.0|
Cyst | | 2 4.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 1 1 1 | 13 1.3|
Inflammation, Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 41 |
Abscess | | 1 4.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | 2 1 | 4 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 2 3 | 8 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 36 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + | 54 |
Atrophy | 4 4 4 4 4 3 4 3 | 31 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | 3 | 1 3.0|
Bilateral, Interstitial Cell, | | |
Hyperplasia | | 1 2.0|
Interstitial Cell, Hyperplasia | 3 | 7 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + | 25 |
Anemia | | 2 |
Hypersegmentation | | 1 |
Neutrophilia | | 3 |
Thrombocytopenia | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 37 |
Depletion Cellular | 3 | 1 3.0|
Myelofibrosis | 2 | 2 2.5|
Myeloid Cell, Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 41 |
Bronchial, Pigmentation, Hemosiderin | | 1 3.0|
Bronchial, Sinus, Ectasia | | 1 3.0|
Iliac, Sinus, Ectasia | | 1 4.0|
Inguinal, Hyperplasia, Plasma Cell | | 1 2.0|
Lumbar, Hyperplasia, Macrophage | | 1 2.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 4.0|
Lumbar, Pigmentation, Hemosiderin | | 1 3.0|
Lumbar, Sinus, Ectasia | | 2 2.0|
Mediastinal, Hyperplasia, Macrophage | | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
Mediastinal, Sinus, Ectasia | | 2 2.0|
Pancreatic, Sinus, Ectasia | | 1 2.0|
Renal, Sinus, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 38 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 4 3.5|
Sinus, Ectasia | 3 | 3 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 38 |
Depletion Lymphoid | 3 | 2 2.5|
Hyperplasia, Macrophage | | 3 3.0|
Sinus, Ectasia | 3 | 5 2.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 52 |
Fibrosis | 4 3 | 5 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 5 3.0|
Capsule, Infarct | | 1 2.0|
Capsule, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + M + M M + + + M + + | 35 |
Cyst | 2 | 1 2.0|
Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + + + | 29 |
Hyperplasia | 2 2 | 8 1.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + | 37 |
Cyst Epithelial Inclusion | | 1 1.0|
Inflammation, Chronic | | 2 2.5|
Inflammation, Granulomatous | | 1 3.0|
Ulcer | | 6 3.0|
Hindlimb, Subcutaneous Tissue, Right,| | |
Inflammation, Acute | | 1 4.0|
Hindlimb, Right, Epidermis, Abscess, | | |
Multiple | | 1 3.0|
Hindlimb, Right, Epidermis, | | |
Degeneration, Ballooning | | 1 4.0|
Sebaceous Gland, Hyperplasia | | 1 3.0|
Subcutaneous Tissue, Cyst | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 37 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 37 |
Compression | | 2 |
Cerebellum, Embolus Tumor | X | 1 |
Cerebellum, Infarct | 3 | 1 3.0|
Choroid Plexus, Inflammation, Chronic| | 1 1.0|
Ventricle, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | + + + | 13 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 38 |
Congestion | | 1 4.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Macrophage | 2 | 2 2.5|
Hyperplasia, Adenomatous | 3 | 2 2.5|
Arteriole, Media, Hyperplasia | | 1 2.0|
Interstitium, Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 37 |
Inflammation, Chronic | 1 3 | 7 2.0|
Metaplasia, Squamous | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 1 1 1 2 | 21 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 1.5|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | 2 2 2 1 2 | 24 1.9|
Respiratory Epithelium, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 37 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Exudate | | 1 |
__________________________________________________________________________|____________|
Eye | | 3 |
Hemorrhage | | 1 3.0|
Synechia | | 2 3.0|
Cornea, Proliferation | | 1 2.0|
Retina, Atrophy | | 3 3.3|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + | 55 |
Cyst | | 2 1.5|
Infarct | | 1 3.0|
Inflammation, Chronic | 2 2 2 2 1 2 2 2 | 30 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 2| 4| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| | |
DAY ON TEST | 0| 2| 3| 3| 8| 3| 3| 3| 2| 1| 3| 3| 2| 7| 5| | |
| 7| 9| 1| 1| 6| 2| 2| 2| 8| 2| 2| 1| 8| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
25 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 3 3 4 3 3 3 2 3 3 3 2 3 4 | 52 2.9|
Pelvis, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Renal Tubule, Inflammation, | | |
Suppurative | 1 1 | 7 1.1|
Transitional Epithelium, Hyperplasia,| | |
Papillary | 2 2 | 6 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 37 |
Hyperplasia, Papillary | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 6| 6| 6| 6| 5| 7| 7| 6| 6| 4| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 7| 5| 5| 1| 8| 8| 7| 3| 2| 3| 2| 1| 0| 5| 0| 8| 1| 6| 5| 3| 3| 3| 0| 4|
| 8| 2| 9| 9| 8| 9| 6| 2| 1| 2| 1| 0| 2| 6| 9| 0| 2| 2| 2| 4| 2| 1| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + +|
Mineralization | 2 |
Muscularis, Inflammation, Chronic | 2 |
Muscularis, Mineralization | 2 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + A + + + + + + + + + + + +|
Muscularis, Mineralization | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
Capillary, Degeneration, Hyaline | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + +|
Capillary, Degeneration, Hyaline | |
Muscularis, Inflammation, Chronic | 3 |
Muscularis, Mineralization | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + M + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 |
Clear Cell Focus | 2 |
Cytomegaly | 2 |
Degeneration, Cystic | 1 1 1 1 1 2 1 3 1 1|
Eosinophilic Focus | 2 |
Fatty Change | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 |
Necrosis, Coagulative | 2 2 1 1 3 |
Necrosis, Coagulative, Multifocal | |
Arteriole, Inflammation, | |
Proliferative | 1 4 |
Arteriole, Thrombosis | X X |
Bile Duct, Hyperplasia | 2 2 2 4 4 2 3 2 3 4 4 2 3 2 3 2 2 4 2 2 3|
Centrilobular, Atrophy | 2 2 2 |
Sinusoid, Dilatation | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Duct, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 6| 6| 6| 6| 5| 7| 7| 6| 6| 4| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 7| 5| 5| 1| 8| 8| 7| 3| 2| 3| 2| 1| 0| 5| 0| 8| 1| 6| 5| 3| 3| 3| 0| 4|
| 8| 2| 9| 9| 8| 9| 6| 2| 1| 2| 1| 0| 2| 6| 9| 0| 2| 2| 2| 4| 2| 1| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy, Focal | 2 |
Duct, Inflammation, Chronic | 2 1 |
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Hyperplasia, Papillary | |
Inflammation, Chronic | |
Ulcer | |
Muscularis, Mineralization | 4 4 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Mineralization | 3 4 3 4 |
Ulcer | 3 |
__________________________________________________________________________|
Tooth | + + + |
Pulp, Proliferation Connective | |
Tissue, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 2 2 3 1 1 3 2 2 3 2 2 1 2 2 2 1 2|
Mineralization | 3 4 3 3 3 |
Atrium, Dilatation | |
Atrium, Thrombosis | 3 X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | |
Degeneration, Fatty, Focal | 2 3 1 |
Hyperplasia | 2 3 1 |
Vacuolization Cytoplasmic | 1 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 2 1 2 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + +|
Cyst | 2 |
Hyperplasia | 4 4 4 4 4 3 4 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 2 2|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 6| 6| 6| 6| 5| 7| 7| 6| 6| 4| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 7| 5| 5| 1| 8| 8| 7| 3| 2| 3| 2| 1| 0| 5| 0| 8| 1| 6| 5| 3| 3| 3| 0| 4|
| 8| 2| 9| 9| 8| 9| 6| 2| 1| 2| 1| 0| 2| 6| 9| 0| 2| 2| 2| 4| 2| 1| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 2 4|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Chronic | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Mucoid | |
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Cyst | 1 4 2 |
Hyperplasia | |
Inflammation, Chronic | 1 2 2 2 2 1 |
Inflammation, Suppurative | |
Necrosis, Coagulative | |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Hyperplasia | |
Inflammation, Chronic | 2 2 3 |
Inflammation, Suppurative | 2 3 2 3 2 2 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 2 1 4 4 3 4 4 4 2 3 3|
Cyst | |
Interstitial Cell, Hyperplasia | 3 2 2 |
Seminiferous Tubule, Degeneration, | |
Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + |
Neutrophilia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 |
Erythroid Cell, Hyperplasia | 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Mediastinal, Atrophy | |
Iliac, Hyperplasia, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 6| 6| 6| 6| 5| 7| 7| 6| 6| 4| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 7| 5| 5| 1| 8| 8| 7| 3| 2| 3| 2| 1| 0| 5| 0| 8| 1| 6| 5| 3| 3| 3| 0| 4|
| 8| 2| 9| 9| 8| 9| 6| 2| 1| 2| 1| 0| 2| 6| 9| 0| 2| 2| 2| 4| 2| 1| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Sinus, Ectasia | |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Plasma Cell | |
Inguinal, Sinus, Ectasia | |
Lumbar, Hyperplasia, Plasma Cell | |
Mediastinal, Hyperplasia, Macrophage | |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mediastinal, Sinus, Ectasia | 4 |
Renal, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hyperplasia, Macrophage | |
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Macrophage | |
Red Pulp, Depletion Cellular | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + +|
Cyst | |
Hyperplasia | |
Mineralization | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + M + + + + + + + + +|
Abscess | |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | |
Ulcer | |
Scrotal, Inflammation, Suppurative | |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Hemorrhage | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 6| 6| 6| 6| 5| 7| 7| 6| 6| 4| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 7| 5| 5| 1| 8| 8| 7| 3| 2| 3| 2| 1| 0| 5| 0| 8| 1| 6| 5| 3| 3| 3| 0| 4|
| 8| 2| 9| 9| 8| 9| 6| 2| 1| 2| 1| 0| 2| 6| 9| 0| 2| 2| 2| 4| 2| 1| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + + |
Degeneration | |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + |
Hemorrhage | 4 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | |
Crystals | 2 |
Hemorrhage | 1 2 |
Hyperplasia, Macrophage | 1 2 2 2 |
Hyperplasia, Adenomatous | 3 |
Inflammation, Suppurative | 2 |
Mineralization | 1 1 |
Necrosis, Liquifactive | |
Proliferation Connective Tissue | |
Arteriole, Thrombosis | |
Interstitium, Fibrosis | 2 |
Interstitium, Inflammation, Chronic | 2 |
Pleura, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 3 |
Inflammation, Suppurative | 3 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 3 2 1 2 2 2 2 2 2 3 3 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 2 3 3 2 3 2 2 3 2 2 3 2 2 3 3 3 3 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Glands, Cyst | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 3| 6| 6| 6| 6| 5| 7| 7| 6| 6| 4| 7| 6| 6| 5| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 7| 5| 5| 1| 8| 8| 7| 3| 2| 3| 2| 1| 0| 5| 0| 8| 1| 6| 5| 3| 3| 3| 0| 4|
| 8| 2| 9| 9| 8| 9| 6| 2| 1| 2| 1| 0| 2| 6| 9| 0| 2| 2| 2| 4| 2| 1| 1| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + |
Cornea, Inflammation, Subacute | |
Cornea, Necrosis | |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 2 |
Hemorrhage | 2 |
Inflammation, Chronic | 1 2 2 2 2 2 1 2 2 2 2 |
Nephropathy | 4 4 2 4 3 3 4 3 4 4 4 3 4 3 2 3 4 4 4 4 3 2|
Pelvis, Inflammation, Suppurative | 2 |
Renal Tubule, Hyperplasia, Focal | 2 |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia,| |
Papillary | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 3 |
Submucosa, Edema | 2 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 0| 3| 0| 3| 1| 9| 8| 5| 3| 3| 3| 5| 0|
| 2| 1| 9| 9| 9| 2| 2| 2| 2| 9| 1| 0| 0| 7| 6| 1| 1| 7| 1| 9| 1| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + +|
Mineralization | |
Muscularis, Inflammation, Chronic | |
Muscularis, Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Mineralization | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
Capillary, Degeneration, Hyaline | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + A + + + + + +|
Capillary, Degeneration, Hyaline | 2 |
Muscularis, Inflammation, Chronic | |
Muscularis, Mineralization | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 2 1 |
Clear Cell Focus | 1 2 |
Cytomegaly | 2 3 |
Degeneration, Cystic | 3 2 2 2 1 |
Eosinophilic Focus | |
Fatty Change | 1 3 1|
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X X X |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 4 |
Inflammation, Chronic | 1 2 1 1 1 |
Necrosis, Coagulative | 2 3 |
Necrosis, Coagulative, Multifocal | |
Arteriole, Inflammation, | |
Proliferative | |
Arteriole, Thrombosis | |
Bile Duct, Hyperplasia | 3 3 3 2 4 3 2 3 3 3 3 2 3 4 3 2 2 3 3 3 2|
Centrilobular, Atrophy | 1 2 2 3|
Sinusoid, Dilatation | 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 2 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 3|
Duct, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 0| 3| 0| 3| 1| 9| 8| 5| 3| 3| 3| 5| 0|
| 2| 1| 9| 9| 9| 2| 2| 2| 2| 9| 1| 0| 0| 7| 6| 1| 1| 7| 1| 9| 1| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy, Focal | |
Duct, Inflammation, Chronic | 1 |
Duct, Metaplasia, Squamous | 1 2 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Hyperplasia, Papillary | 2 |
Inflammation, Chronic | |
Ulcer | |
Muscularis, Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | |
Ulcer | |
__________________________________________________________________________|
Tooth | + + + + + + |
Pulp, Proliferation Connective | |
Tissue, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 2 2 2 3 2 2 3 2 2 1 2 2 3 |
Mineralization | |
Atrium, Dilatation | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Angiectasis | 2 |
Degeneration, Fatty, Focal | 2 2 2 |
Hyperplasia | 2 1 2 2 1 1 |
Vacuolization Cytoplasmic | 1 2|
Capsule, Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 3 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 3 4 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 2 2 |
Pars Distalis, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 0| 3| 0| 3| 1| 9| 8| 5| 3| 3| 3| 5| 0|
| 2| 1| 9| 9| 9| 2| 2| 2| 2| 9| 1| 0| 0| 7| 6| 1| 1| 7| 1| 9| 1| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Mucoid | 3 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | 3 2 2 3 |
Hyperplasia | 3 |
Inflammation, Chronic | 3 1 1 1 3 1 1 |
Inflammation, Suppurative | 1 |
Necrosis, Coagulative | 3 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2|
Hyperplasia | 1 1 1 1 |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 4 3 4 4 2 4 4 3 4 2 3|
Cyst | 2 |
Interstitial Cell, Hyperplasia | 2|
Seminiferous Tubule, Degeneration, | |
Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + +|
Neutrophilia | X|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
Erythroid Cell, Hyperplasia | 3 |
Myeloid Cell, Hyperplasia | 3 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Cortex, Mediastinal, Atrophy | |
Iliac, Hyperplasia, Plasma Cell | 3|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 0| 3| 0| 3| 1| 9| 8| 5| 3| 3| 3| 5| 0|
| 2| 1| 9| 9| 9| 2| 2| 2| 2| 9| 1| 0| 0| 7| 6| 1| 1| 7| 1| 9| 1| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Sinus, Ectasia | 3|
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Plasma Cell | 4|
Inguinal, Sinus, Ectasia | |
Lumbar, Hyperplasia, Plasma Cell | 3|
Mediastinal, Hyperplasia, Macrophage | 2 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 |
Mediastinal, Sinus, Ectasia | 2 |
Renal, Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hyperplasia, Macrophage | |
Hyperplasia, Plasma Cell | 3|
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 4 2 3 3 3 |
Hematopoietic Cell Proliferation | 3 3|
Hyperplasia, Macrophage | 1 |
Red Pulp, Depletion Cellular | |
__________________________________________________________________________|
Thymus | M M + M + M M + + M + + + + M + + + + + +|
Congestion | |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + +|
Cyst | |
Hyperplasia | 2 2 |
Mineralization | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3|
Inflammation, Chronic | 3 2 3|
Inflammation, Suppurative | |
Ulcer | 2|
Scrotal, Inflammation, Suppurative | 3|
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Edema | 4|
Subcutaneous Tissue, Hemorrhage | 3 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 0| 3| 0| 3| 1| 9| 8| 5| 3| 3| 3| 5| 0|
| 2| 1| 9| 9| 9| 2| 2| 2| 2| 9| 1| 0| 0| 7| 6| 1| 1| 7| 1| 9| 1| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Degeneration | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Compression | |
__________________________________________________________________________|
Spinal Cord | + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
Hemorrhage | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | 2 |
Crystals | |
Hemorrhage | 2 |
Hyperplasia, Macrophage | 1 2 |
Hyperplasia, Adenomatous | |
Inflammation, Suppurative | |
Mineralization | |
Necrosis, Liquifactive | 2 |
Proliferation Connective Tissue | 3 |
Arteriole, Thrombosis | X |
Interstitium, Fibrosis | |
Interstitium, Inflammation, Chronic | |
Pleura, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Inflammation, Suppurative | 3 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 1 2 2 2 1 2 2 3 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 2 3 2 3 2 3 2 2 2 2 1 3 3 2 2 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Glands, Cyst | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 5| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 6| 5| 5| 3| 3| 3| 3| 5| 3| 1| 0| 3| 0| 3| 1| 9| 8| 5| 3| 3| 3| 5| 0|
| 2| 1| 9| 9| 9| 2| 2| 2| 2| 9| 1| 0| 0| 7| 6| 1| 1| 7| 1| 9| 1| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Subacute | |
Cornea, Necrosis | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hemorrhage | |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 |
Nephropathy | 4 4 4 3 4 4 4 3 3 4 3 2 4 3 3 2 4 4 4 3 1|
Pelvis, Inflammation, Suppurative | |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Hyperplasia | 2 |
Transitional Epithelium, Hyperplasia,| |
Papillary | 3 1 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Submucosa, Edema | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 0| 3| 7| 7| 5| 3| 7| 3| 9| 5| 3| 1| 5| 5| 5| | |
| 2| 1| 2| 3| 9| 2| 6| 8| 8| 9| 2| 8| 1| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 53 |
Mineralization | | 1 2.0|
Muscularis, Inflammation, Chronic | | 1 2.0|
Muscularis, Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 52 |
Muscularis, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + | 55 |
Capillary, Degeneration, Hyaline | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + | 55 |
Muscularis, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + | 49 |
Capillary, Degeneration, Hyaline | | 1 2.0|
Muscularis, Inflammation, Chronic | | 1 3.0|
Muscularis, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + A + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 55 |
Basophilic Focus | | 6 1.3|
Clear Cell Focus | 3 | 4 2.0|
Cytomegaly | | 3 2.3|
Degeneration, Cystic | 2 2 2 | 18 1.6|
Eosinophilic Focus | | 1 2.0|
Fatty Change | 1 | 4 1.5|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | | 9 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia, Multifocal | | 1 4.0|
Inflammation, Chronic | 1 2 1 1 1 1 | 19 1.1|
Necrosis, Coagulative | | 7 2.0|
Necrosis, Coagulative, Multifocal | 3 | 1 3.0|
Arteriole, Inflammation, | | |
Proliferative | 3 | 3 2.7|
Arteriole, Thrombosis | | 2 |
Bile Duct, Hyperplasia | 3 3 1 3 3 2 3 2 3 1 3 1 | 54 2.7|
Centrilobular, Atrophy | 2 2 2 | 10 2.0|
Sinusoid, Dilatation | | 4 2.3|
__________________________________________________________________________|____________|
Mesentery | + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 0| 3| 7| 7| 5| 3| 7| 3| 9| 5| 3| 1| 5| 5| 5| | |
| 2| 1| 2| 3| 9| 2| 6| 8| 8| 9| 2| 8| 1| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + | 54 |
Atrophy | 2 | 5 1.8|
Duct, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 55 |
Atrophy, Focal | | 1 2.0|
Duct, Inflammation, Chronic | 1 1 | 5 1.2|
Duct, Metaplasia, Squamous | | 6 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 55 |
Acanthosis | 2 3 | 2 2.5|
Hyperkeratosis | 2 3 | 2 2.5|
Hyperplasia, Papillary | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Ulcer | 3 | 1 3.0|
Muscularis, Mineralization | | 4 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 55 |
Inflammation, Chronic | | 1 2.0|
Mineralization | 2 | 5 3.2|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 10 |
Pulp, Proliferation Connective | | |
Tissue, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 55 |
Cardiomyopathy | 3 1 2 3 2 4 2 1 2 2 | 47 2.1|
Mineralization | 2 3 | 7 3.0|
Atrium, Dilatation | 3 | 1 3.0|
Atrium, Thrombosis | X | 4 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + | 54 |
Accessory Adrenal Cortical Nodule | | 1 |
Angiectasis | | 1 2.0|
Degeneration, Fatty, Focal | | 6 2.0|
Hyperplasia | 2 2 | 11 1.7|
Vacuolization Cytoplasmic | 2 3 3 1 | 7 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 0| 3| 7| 7| 5| 3| 7| 3| 9| 5| 3| 1| 5| 5| 5| | |
| 2| 1| 2| 3| 9| 2| 6| 8| 8| 9| 2| 8| 1| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 55 |
Hyperplasia | 2 3 1 2 2 2 2 | 22 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + | 54 |
Cyst | | 1 2.0|
Hyperplasia | 2 3 3 4 3 4 | 19 3.4|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 54 |
Pars Distalis, Cyst | 1 4 1 | 7 2.0|
Pars Distalis, Hyperplasia | 3 3 3 2 2 | 11 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 55 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia | 2 | 7 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + | 55 |
Degeneration, Mucoid | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + | 54 |
Abscess | | 1 2.0|
Cyst | | 7 2.4|
Hyperplasia | | 1 3.0|
Inflammation, Chronic | | 13 1.6|
Inflammation, Suppurative | | 1 1.0|
Necrosis, Coagulative | | 1 3.0|
Pigmentation, Hemosiderin | | 2 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + | 55 |
Abscess | | 1 2.0|
Hyperplasia | | 4 1.0|
Inflammation, Chronic | 1 | 5 1.8|
Inflammation, Suppurative | 3 2 2 2 | 13 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + | 55 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + | 55 |
Atrophy | 3 4 3 3 3 4 3 3 | 35 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 0| 3| 7| 7| 5| 3| 7| 3| 9| 5| 3| 1| 5| 5| 5| | |
| 2| 1| 2| 3| 9| 2| 6| 8| 8| 9| 2| 8| 1| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 1 2.0|
Interstitial Cell, Hyperplasia | 4 3 2 | 7 2.6|
Seminiferous Tubule, Degeneration, | | |
Cystic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + | 29 |
Neutrophilia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 55 |
Myelofibrosis | | 3 2.0|
Erythroid Cell, Hyperplasia | | 2 2.5|
Myeloid Cell, Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 55 |
Cortex, Mediastinal, Atrophy | 4 | 1 4.0|
Iliac, Hyperplasia, Plasma Cell | | 1 3.0|
Iliac, Sinus, Ectasia | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
Inguinal, Hyperplasia, Plasma Cell | 4 | 2 4.0|
Inguinal, Sinus, Ectasia | 4 | 1 4.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Mediastinal, Hyperplasia, Macrophage | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 2.0|
Mediastinal, Sinus, Ectasia | 3 | 3 3.0|
Renal, Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + | 54 |
Hyperplasia, Plasma Cell | 4 2 | 3 3.0|
Sinus, Ectasia | 4 3 | 4 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + | 54 |
Depletion Lymphoid | | 1 2.0|
Hyperplasia, Macrophage | 2 | 1 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
Sinus, Ectasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 55 |
Fibrosis | | 8 2.4|
Hematopoietic Cell Proliferation | | 3 3.0|
Hyperplasia, Macrophage | | 1 1.0|
Red Pulp, Depletion Cellular | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 0| 3| 7| 7| 5| 3| 7| 3| 9| 5| 3| 1| 5| 5| 5| | |
| 2| 1| 2| 3| 9| 2| 6| 8| 8| 9| 2| 8| 1| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + M | 46 |
Congestion | | 1 3.0|
Cyst | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 53 |
Cyst | 3 | 1 3.0|
Hyperplasia | 2 2 2 4 2 2 2 2 | 10 2.2|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 54 |
Abscess | | 1 3.0|
Inflammation, Chronic | 3 | 5 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
Ulcer | 3 3 3 | 4 2.8|
Scrotal, Inflammation, Suppurative | | 1 3.0|
Subcutaneous Tissue, Abscess | 4 4 | 2 4.0|
Subcutaneous Tissue, Edema | | 1 4.0|
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 55 |
Fibrous Osteodystrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 6 |
Degeneration | | 1 2.0|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 55 |
Compression | X X | 3 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 9 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | | 1 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 55 |
Atelectasis | | 1 2.0|
Crystals | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 0| 3| 7| 7| 5| 3| 7| 3| 9| 5| 3| 1| 5| 5| 5| | |
| 2| 1| 2| 3| 9| 2| 6| 8| 8| 9| 2| 8| 1| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | | 3 1.7|
Hyperplasia, Macrophage | | 6 1.7|
Hyperplasia, Adenomatous | | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
Mineralization | | 2 1.0|
Necrosis, Liquifactive | | 1 2.0|
Proliferation Connective Tissue | | 1 3.0|
Arteriole, Thrombosis | 2 | 2 2.0|
Interstitium, Fibrosis | | 1 2.0|
Interstitium, Inflammation, Chronic | | 1 2.0|
Pleura, Inflammation, Chronic | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 55 |
Inflammation, Chronic | 2 | 6 2.2|
Inflammation, Suppurative | | 2 3.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 2 1 2 2 3 2 1 1 2 | 34 1.9|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 2 1.5|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | 1 2 1 2 4 4 2 3 4 3 1 2 | 47 2.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 55 |
Inflammation, Chronic | | 1 2.0|
Glands, Cyst | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Cornea, Inflammation, Subacute | 2 | 1 2.0|
Cornea, Necrosis | 2 | 1 2.0|
Retina, Atrophy | 4 | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 55 |
Cyst | 2 2 | 6 2.5|
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 2 2 2 2 1 3 2 | 27 1.9|
Nephropathy | 4 4 4 3 4 4 4 4 4 4 1 1 | 55 3.4|
Pelvis, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05040-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HYDROQUINONE Date: 05/01/97
Route: GAVAGE Time: 09:41:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 4| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 0| 3| 7| 7| 5| 3| 7| 3| 9| 5| 3| 1| 5| 5| 5| | |
| 2| 1| 2| 3| 9| 2| 6| 8| 8| 9| 2| 8| 1| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
50 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Hyperplasia, Focal | | 1 2.0|
Renal Tubule, Hyperplasia | | 1 2.0|
Transitional Epithelium, Hyperplasia,| | |
Papillary | 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + | 55 |
Inflammation, Chronic | 1 | 3 1.0|
Inflammation, Chronic Active | | 1 3.0|
Submucosa, Edema | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
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